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Conserved domains on  [gi|1246742136|ref|NP_001342904|]
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metaxin 1 [Schizosaccharomyces pombe]

Protein Classification

GST_N_Metaxin1_like and GST_C_Metaxin domain-containing protein( domain architecture ID 12107611)

GST_N_Metaxin1_like and GST_C_Metaxin domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tom37 pfam10568
Outer mitochondrial membrane transport complex protein; The TOM37 protein is one of the outer ...
 20-141 4.37e-33

Outer mitochondrial membrane transport complex protein; The TOM37 protein is one of the outer membrane proteins that make up the TOM complex for guiding cytosolic mitochondrial beta-barrel proteins from the cytosol across the outer mitochondrial membrane into the intra-membrane space. In conjunction with TOM70 it guides peptides without an MTS into TOM40, the protein that forms the passage through the outer membrane. It has homology with Metaxin-1, also part of the outer mitochondrial membrane beta-barrel protein transport complex.


:

Pssm-ID: 463150  Cd Length: 126  Bit Score: 121.20  E-value: 4.37e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742136  20 CLAALIYCALAVPKDEIEILRTANSGMSPTHKLPALWDGH-VWIGSLKNILIYLKQK--GYNLD-NFDAKQLANVMAFTS 95
Cdd:pfam10568   1 CLAAIAYLKLLALPAPFEVVPSNNPDLSPTGELPALIDGDgTWVSGFDSIVEYLRSKggGYDLDaDLSAKQKADSLAYIS 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1246742136  96 LLEGSVNDLWLLEAFVNEENFVEAIRPAWSKALKFPHNYLTPNALQ 141
Cdd:pfam10568  81 LLESKLYPLLLYSLWVDEENYEEVTRPAYSKLLPFPLNYILPLKYR 126
GST_C_Metaxin cd03193
C-terminal, alpha helical domain of Metaxin and related proteins; Glutathione S-transferase ...
 189-262 1.91e-15

C-terminal, alpha helical domain of Metaxin and related proteins; Glutathione S-transferase (GST) C-terminal domain family, Metaxin subfamily; composed of metaxins and related proteins. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It extends to the cytosol and is anchored to the mitochondrial membrane through its C-terminal domain. In mice, metaxin is required for embryonic development. In humans, alterations in the metaxin gene may be associated with Gaucher disease. Metaxin 2 binds to metaxin 1 and may also play a role in protein translocation into the mitochondria. Genome sequencing shows that a third metaxin gene also exists in zebrafish, Xenopus, chicken, and mammals. Sequence analysis suggests that all three metaxins share a common ancestry and that they possess similarity to GSTs. Also included in the subfamily are uncharacterized proteins with similarity to metaxins, including a novel GST from Rhodococcus with toluene o-monooxygenase and glutamylcysteine synthetase activities. Other members are the cadmium-inducible lysosomal protein CDR-1 and its homologs from C. elegans, and the failed axon connections (fax) protein from Drosophila. CDR-1 is an integral membrane protein that functions to protect against cadmium toxicity and may also have a role in osmoregulation to maintain salt balance in C. elegans. The fax gene of Drosophila was identified as a genetic modifier of Abelson (Abl) tyrosine kinase. The fax protein is localized in cellular membranes and is expressed in embryonic mesoderm and axons of the central nervous system.


:

Pssm-ID: 198302 [Multi-domain]  Cd Length: 88  Bit Score: 71.50  E-value: 1.91e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1246742136 189 RIRISSLARQVYGSLESLISDSKFIFGEKPTSLDCLFYAYLSFHAFTNELPQatLRPCLQFNSPKLYAYLKSLR 262
Cdd:cd03193    17 RREIYELALEDLEALSTLLGDKKFLFGDKPTSVDATVFAHLASILYPPEDSP--LLRVLVASSPNLVEYCERIR 88
 
Name Accession Description Interval E-value
Tom37 pfam10568
Outer mitochondrial membrane transport complex protein; The TOM37 protein is one of the outer ...
 20-141 4.37e-33

Outer mitochondrial membrane transport complex protein; The TOM37 protein is one of the outer membrane proteins that make up the TOM complex for guiding cytosolic mitochondrial beta-barrel proteins from the cytosol across the outer mitochondrial membrane into the intra-membrane space. In conjunction with TOM70 it guides peptides without an MTS into TOM40, the protein that forms the passage through the outer membrane. It has homology with Metaxin-1, also part of the outer mitochondrial membrane beta-barrel protein transport complex.


Pssm-ID: 463150  Cd Length: 126  Bit Score: 121.20  E-value: 4.37e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742136  20 CLAALIYCALAVPKDEIEILRTANSGMSPTHKLPALWDGH-VWIGSLKNILIYLKQK--GYNLD-NFDAKQLANVMAFTS 95
Cdd:pfam10568   1 CLAAIAYLKLLALPAPFEVVPSNNPDLSPTGELPALIDGDgTWVSGFDSIVEYLRSKggGYDLDaDLSAKQKADSLAYIS 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1246742136  96 LLEGSVNDLWLLEAFVNEENFVEAIRPAWSKALKFPHNYLTPNALQ 141
Cdd:pfam10568  81 LLESKLYPLLLYSLWVDEENYEEVTRPAYSKLLPFPLNYILPLKYR 126
GST_N_Metaxin1_like cd03078
GST_N family, Metaxin subfamily, Metaxin 1-like proteins; composed of metaxins 1 and 3, and ...
 2-76 4.20e-22

GST_N family, Metaxin subfamily, Metaxin 1-like proteins; composed of metaxins 1 and 3, and similar proteins including Tom37 from fungi. Mammalian metaxin (or metaxin 1) and the fungal protein Tom37 are components of preprotein import complexes of the mitochondrial outer membrane. Metaxin extends to the cytosol and is anchored to the mitochondrial membrane through its C-terminal domain. In mice, metaxin is required for embryonic development. Like the murine gene, the human metaxin gene is located downstream to the glucocerebrosidase (GBA) pseudogene and is convergently transcribed. Inherited deficiency of GBA results in Gaucher disease, which presents many diverse clinical phenotypes. Alterations in the metaxin gene, in addition to GBA mutations, may be associated with Gaucher disease. Genome sequencing shows that a third metaxin gene also exists in zebrafish, Xenopus, chicken and mammals.


Pssm-ID: 239376  Cd Length: 73  Bit Score: 89.64  E-value: 4.20e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1246742136   2 LQLFIYSPGLGQPTMDPGCLAALIYCALAvpKDEIEILRTANSGMSPTHKLPALWDGHVWIGSLKNILIYLKQKG 76
Cdd:cd03078     1 MELHVWGGDWGLPSVDPECLAVLAYLKFA--GAPLKVVPSNNPWRSPTGKLPALLTSGTKISGPEKIIEYLRKQG 73
GST_C_Metaxin cd03193
C-terminal, alpha helical domain of Metaxin and related proteins; Glutathione S-transferase ...
 189-262 1.91e-15

C-terminal, alpha helical domain of Metaxin and related proteins; Glutathione S-transferase (GST) C-terminal domain family, Metaxin subfamily; composed of metaxins and related proteins. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It extends to the cytosol and is anchored to the mitochondrial membrane through its C-terminal domain. In mice, metaxin is required for embryonic development. In humans, alterations in the metaxin gene may be associated with Gaucher disease. Metaxin 2 binds to metaxin 1 and may also play a role in protein translocation into the mitochondria. Genome sequencing shows that a third metaxin gene also exists in zebrafish, Xenopus, chicken, and mammals. Sequence analysis suggests that all three metaxins share a common ancestry and that they possess similarity to GSTs. Also included in the subfamily are uncharacterized proteins with similarity to metaxins, including a novel GST from Rhodococcus with toluene o-monooxygenase and glutamylcysteine synthetase activities. Other members are the cadmium-inducible lysosomal protein CDR-1 and its homologs from C. elegans, and the failed axon connections (fax) protein from Drosophila. CDR-1 is an integral membrane protein that functions to protect against cadmium toxicity and may also have a role in osmoregulation to maintain salt balance in C. elegans. The fax gene of Drosophila was identified as a genetic modifier of Abelson (Abl) tyrosine kinase. The fax protein is localized in cellular membranes and is expressed in embryonic mesoderm and axons of the central nervous system.


Pssm-ID: 198302 [Multi-domain]  Cd Length: 88  Bit Score: 71.50  E-value: 1.91e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1246742136 189 RIRISSLARQVYGSLESLISDSKFIFGEKPTSLDCLFYAYLSFHAFTNELPQatLRPCLQFNSPKLYAYLKSLR 262
Cdd:cd03193    17 RREIYELALEDLEALSTLLGDKKFLFGDKPTSVDATVFAHLASILYPPEDSP--LLRVLVASSPNLVEYCERIR 88
GST_C_6 pfam17171
Glutathione S-transferase, C-terminal domain; This domain is closely related to PF00043.
 196-261 1.92e-07

Glutathione S-transferase, C-terminal domain; This domain is closely related to PF00043.


Pssm-ID: 465369  Cd Length: 64  Bit Score: 47.91  E-value: 1.92e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1246742136 196 ARQVYGSLESLISDSKFIFGEKPTSLDCLFYAYLSFHAFTNelpqatlrpclqFNSPKLYAYLKSL 261
Cdd:pfam17171   1 AKKDLRALSERLGDKPFFFGDKPTSLDALVFGHLALILYTP------------LPSPALRIHLKEY 54
 
Name Accession Description Interval E-value
Tom37 pfam10568
Outer mitochondrial membrane transport complex protein; The TOM37 protein is one of the outer ...
 20-141 4.37e-33

Outer mitochondrial membrane transport complex protein; The TOM37 protein is one of the outer membrane proteins that make up the TOM complex for guiding cytosolic mitochondrial beta-barrel proteins from the cytosol across the outer mitochondrial membrane into the intra-membrane space. In conjunction with TOM70 it guides peptides without an MTS into TOM40, the protein that forms the passage through the outer membrane. It has homology with Metaxin-1, also part of the outer mitochondrial membrane beta-barrel protein transport complex.


Pssm-ID: 463150  Cd Length: 126  Bit Score: 121.20  E-value: 4.37e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742136  20 CLAALIYCALAVPKDEIEILRTANSGMSPTHKLPALWDGH-VWIGSLKNILIYLKQK--GYNLD-NFDAKQLANVMAFTS 95
Cdd:pfam10568   1 CLAAIAYLKLLALPAPFEVVPSNNPDLSPTGELPALIDGDgTWVSGFDSIVEYLRSKggGYDLDaDLSAKQKADSLAYIS 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1246742136  96 LLEGSVNDLWLLEAFVNEENFVEAIRPAWSKALKFPHNYLTPNALQ 141
Cdd:pfam10568  81 LLESKLYPLLLYSLWVDEENYEEVTRPAYSKLLPFPLNYILPLKYR 126
GST_N_Metaxin1_like cd03078
GST_N family, Metaxin subfamily, Metaxin 1-like proteins; composed of metaxins 1 and 3, and ...
 2-76 4.20e-22

GST_N family, Metaxin subfamily, Metaxin 1-like proteins; composed of metaxins 1 and 3, and similar proteins including Tom37 from fungi. Mammalian metaxin (or metaxin 1) and the fungal protein Tom37 are components of preprotein import complexes of the mitochondrial outer membrane. Metaxin extends to the cytosol and is anchored to the mitochondrial membrane through its C-terminal domain. In mice, metaxin is required for embryonic development. Like the murine gene, the human metaxin gene is located downstream to the glucocerebrosidase (GBA) pseudogene and is convergently transcribed. Inherited deficiency of GBA results in Gaucher disease, which presents many diverse clinical phenotypes. Alterations in the metaxin gene, in addition to GBA mutations, may be associated with Gaucher disease. Genome sequencing shows that a third metaxin gene also exists in zebrafish, Xenopus, chicken and mammals.


Pssm-ID: 239376  Cd Length: 73  Bit Score: 89.64  E-value: 4.20e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1246742136   2 LQLFIYSPGLGQPTMDPGCLAALIYCALAvpKDEIEILRTANSGMSPTHKLPALWDGHVWIGSLKNILIYLKQKG 76
Cdd:cd03078     1 MELHVWGGDWGLPSVDPECLAVLAYLKFA--GAPLKVVPSNNPWRSPTGKLPALLTSGTKISGPEKIIEYLRKQG 73
GST_N_Metaxin cd03054
GST_N family, Metaxin subfamily; composed of metaxins and related proteins. Metaxin 1 is a ...
 2-75 4.86e-16

GST_N family, Metaxin subfamily; composed of metaxins and related proteins. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It extends to the cytosol and is anchored to the mitochondrial membrane through its C-terminal domain. In mice, metaxin is required for embryonic development. In humans, alterations in the metaxin gene may be associated with Gaucher disease. Metaxin 2 binds to metaxin 1 and may also play a role in protein translocation into the mitochondria. Genome sequencing shows that a third metaxin gene also exists in zebrafish, Xenopus, chicken and mammals. Sequence analysis suggests that all three metaxins share a common ancestry and that they possess similarity to GSTs. Also included in the subfamily are uncharacterized proteins with similarity to metaxins, including a novel GST from Rhodococcus with toluene o-monooxygenase and glutamylcysteine synthetase activities.


Pssm-ID: 239352 [Multi-domain]  Cd Length: 72  Bit Score: 72.65  E-value: 4.86e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1246742136   2 LQLFIYSPGLGQPTMDPGCLAALIYCALAvpKDEIEILRTANSGMSPTHKLPALWDGHVWIGSLKNILIYLKQK 75
Cdd:cd03054     1 LELYQWGRAFGLPSLSPECLKVETYLRMA--GIPYEVVFSSNPWRSPTGKLPFLELNGEKIADSEKIIEYLKKK 72
GST_C_Metaxin cd03193
C-terminal, alpha helical domain of Metaxin and related proteins; Glutathione S-transferase ...
 189-262 1.91e-15

C-terminal, alpha helical domain of Metaxin and related proteins; Glutathione S-transferase (GST) C-terminal domain family, Metaxin subfamily; composed of metaxins and related proteins. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It extends to the cytosol and is anchored to the mitochondrial membrane through its C-terminal domain. In mice, metaxin is required for embryonic development. In humans, alterations in the metaxin gene may be associated with Gaucher disease. Metaxin 2 binds to metaxin 1 and may also play a role in protein translocation into the mitochondria. Genome sequencing shows that a third metaxin gene also exists in zebrafish, Xenopus, chicken, and mammals. Sequence analysis suggests that all three metaxins share a common ancestry and that they possess similarity to GSTs. Also included in the subfamily are uncharacterized proteins with similarity to metaxins, including a novel GST from Rhodococcus with toluene o-monooxygenase and glutamylcysteine synthetase activities. Other members are the cadmium-inducible lysosomal protein CDR-1 and its homologs from C. elegans, and the failed axon connections (fax) protein from Drosophila. CDR-1 is an integral membrane protein that functions to protect against cadmium toxicity and may also have a role in osmoregulation to maintain salt balance in C. elegans. The fax gene of Drosophila was identified as a genetic modifier of Abelson (Abl) tyrosine kinase. The fax protein is localized in cellular membranes and is expressed in embryonic mesoderm and axons of the central nervous system.


Pssm-ID: 198302 [Multi-domain]  Cd Length: 88  Bit Score: 71.50  E-value: 1.91e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1246742136 189 RIRISSLARQVYGSLESLISDSKFIFGEKPTSLDCLFYAYLSFHAFTNELPQatLRPCLQFNSPKLYAYLKSLR 262
Cdd:cd03193    17 RREIYELALEDLEALSTLLGDKKFLFGDKPTSVDATVFAHLASILYPPEDSP--LLRVLVASSPNLVEYCERIR 88
GST_C_Metaxin1_3 cd03212
C-terminal, alpha helical domain of Metaxin 1, Metaxin 3, and similar proteins; Glutathione ...
 110-266 2.40e-14

C-terminal, alpha helical domain of Metaxin 1, Metaxin 3, and similar proteins; Glutathione S-transferase (GST) C-terminal domain family, Metaxin subfamily, Metaxin 1-like proteins; composed of metaxins 1 and 3, and similar proteins. Mammalian metaxin (or metaxin 1) is a component of the preprotein import complex of the mitochondrial outer membrane. Metaxin extends to the cytosol and is anchored to the mitochondrial membrane through its C-terminal domain. In mice, metaxin is required for embryonic development. Like the murine gene, the human metaxin gene is located downstream to the glucocerebrosidase (GBA) pseudogene and is convergently transcribed. Inherited deficiency of GBA results in Gaucher disease, which presents many diverse clinical phenotypes. Alterations in the metaxin gene, in addition to GBA mutations, may be associated with Gaucher disease. Genome sequencing shows that a third metaxin gene also exists in zebrafish, Xenopus, chicken, and mammals.


Pssm-ID: 198321 [Multi-domain]  Cd Length: 137  Bit Score: 69.59  E-value: 2.40e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742136 110 FVNEENFVEAIRPAWSKALKFPHNYLTPNALQRQAKERLaQTLGIRDEEVSYEASRMPISHKwtnatrhrqallrtqarr 189
Cdd:cd03212     8 WVDEKNYVEVTRPWYAKALPFPLNFYYPGRYQRRAKDRL-QLLRGLSELDSEEEVEKELYKD------------------ 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742136 190 irisslARQVYGSLESLISDSKFIFGEKPTSLDCLFYAYLS--FHA-FTNELPQATLRPClqfnsPKLYAYLKSLRETWF 266
Cdd:cd03212    69 ------AKECLNLLSERLGEKKFFFGDRPTSLDALVFGYLAplLKApLPNNKLQNHLKGC-----PNLVQFVDRILQNYF 137
GST_N_4 pfam17172
Glutathione S-transferase N-terminal domain; This domain is homologous to pfam02798.
 18-115 1.75e-10

Glutathione S-transferase N-terminal domain; This domain is homologous to pfam02798.


Pssm-ID: 465370 [Multi-domain]  Cd Length: 97  Bit Score: 57.59  E-value: 1.75e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742136  18 PGCLAALIYCALA-VPkdeIEILRTANSGMSPTHKLPALWDGHVWIGSLKNILIYLKQKGYNLD-NFDAKQLANVMAFTS 95
Cdd:pfam17172   1 PFCLKVETYLRMAgIP---YEVEPSSNPSASPKGKLPFIELNGDLIADSEFIIEFLKEKGVDLDaGLSPEQKADARALKA 77

                          90       100
                  ....*....|....*....|
gi 1246742136  96 LLEGSVNDLWLLEAFVNEEN 115
Cdd:pfam17172  78 LVEEHLYWALLYERWLDPEN 97
GST_C_6 pfam17171
Glutathione S-transferase, C-terminal domain; This domain is closely related to PF00043.
 196-261 1.92e-07

Glutathione S-transferase, C-terminal domain; This domain is closely related to PF00043.


Pssm-ID: 465369  Cd Length: 64  Bit Score: 47.91  E-value: 1.92e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1246742136 196 ARQVYGSLESLISDSKFIFGEKPTSLDCLFYAYLSFHAFTNelpqatlrpclqFNSPKLYAYLKSL 261
Cdd:pfam17171   1 AKKDLRALSERLGDKPFFFGDKPTSLDALVFGHLALILYTP------------LPSPALRIHLKEY 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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