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Conserved domains on  [gi|1484505927|ref|NP_001353299|]
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DNA replication licensing factor MCM3 isoform 4 [Homo sapiens]

Protein Classification

DNA replication licensing factor MCM( domain architecture ID 12168656)

DNA replication licensing factor MCM (minichromosome maintenance protein MCM) is one of the highly conserved MCM complex proteins; the complex may have helicase activity and is essential for the initiation of DNA replication

EC:  3.6.4.12
Gene Ontology:  GO:0042555|GO:0003678|GO:0006270|GO:0006271|GO:0016887|GO:0046872|GO:0003677|GO:0005524|GO:0032508
PubMed:  8332451|18208397|22841721|17506634

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MCM smart00350
minichromosome maintenance proteins;
109-671 0e+00

minichromosome maintenance proteins;


:

Pssm-ID: 214631 [Multi-domain]  Cd Length: 509  Bit Score: 734.84  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927  109 KHVSPRTLTSCFLSCVVCVEGIVTKCSLVRPKVVRS---VHYCPATKKTIERRYSDLTTLVAFPSSSVYPTkdeennPLE 185
Cdd:smart00350   1 KPSSIRELRADHLGKLVRISGIVTRTSGVRPKLKRAsftCEKCGATLGPEIQSGRETEPTVCPPRECQSPT------PFS 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927  186 TEYGLSVYKDHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKAKPGDRVQVVGTYRCLP-GKKGGYTSGT--FRTVLIA 262
Cdd:smart00350  75 LNHERSTFIDFQKIKLQESPEEVPVGQLPRSVDVILDGDLVDKAKPGDRVEVTGIYRNVPyGFKLNTVKGLpvFATYIEA 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927  263 CNVK----QMSKDAQP----SFSAEDIAKIKKFSKtrSKDIFDQLAKSLAPSIHGHDYVKKAILCLLLGGVERDLENGSH 334
Cdd:smart00350 155 NHVRkldyKRSFEDSSfsvqSLSDEEEEEIRKLSK--DPDIYERLARSLAPSIYGHEDIKKAILLLLFGGVHKNLPDGMK 232

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927  335 IRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKM 414
Cdd:smart00350 233 IRGDINILLCGDPGTAKSQLLKYVEKTAPRAVYTTGKGSSAVGLTAAVTRDPETREFTLEAGALVLADNGVCCIDEFDKM 312

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927  415 SDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQD 494
Cdd:smart00350 313 DDSDRTAIHEAMEQQTISIAKAGITTTLNARCSVLAAANPIGGRYDPKLTPEENIDLPAPILSRFDLLFVVLDEVDEERD 392

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927  495 REISDHVLRMHRYRAPgeqdgdamplgsavdilatddpnfsQEDQQDtqiyekhdnllhgtkkkkqvvrcgremeftvcg 574
Cdd:smart00350 393 RELAKHVVDLHRYSHP-------------------------EEDEAF--------------------------------- 414

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927  575 srEKMVSAAFMKKYIHVAK-IIKPVLTQESATYIAEEYSRLRSQDSmSSDTARTSPVTARTLETLIRLATAHAKARMSKT 653
Cdd:smart00350 415 --EPPLSQEKLRKYIAYAReKIKPKLSEEAADKLVKAYVDLRKEDS-QTESRSSIPITVRQLESIIRLSEAHAKMRLSDV 491

                          570
                   ....*....|....*...
gi 1484505927  654 VDLQDAEEAVELVQYAYF 671
Cdd:smart00350 492 VEEADVEEAIRLLRESII 509
MCM_N pfam14551
MCM N-terminal domain; This family contains the N-terminal domain of MCM proteins.
 16-104 9.90e-17

MCM N-terminal domain; This family contains the N-terminal domain of MCM proteins.


:

Pssm-ID: 464206 [Multi-domain]  Cd Length: 95  Bit Score: 76.18  E-value: 9.90e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927  16 QRDYLDFLD----DEEDQGIYQSKVRELISDNQYRLIVNVNDLRRKNEKRANRLLNNAFEELVAFQRALKDFVASI--DA 89
Cdd:pfam14551   1 KRKFKDFLEefreDGDGEFKYRDQLREMIEREQRSLEVDLDDLREFDPDLAEALLENPYEYLPLFEEALKEVVKELseDP 80

                          90
                  ....*....|....*
gi 1484505927  90 TYAKQYEEFYVGLEG 104
Cdd:pfam14551  81 DYAEEEKEFQVRFYN 95
 
Name Accession Description Interval E-value
MCM smart00350
minichromosome maintenance proteins;
109-671 0e+00

minichromosome maintenance proteins;


Pssm-ID: 214631 [Multi-domain]  Cd Length: 509  Bit Score: 734.84  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927  109 KHVSPRTLTSCFLSCVVCVEGIVTKCSLVRPKVVRS---VHYCPATKKTIERRYSDLTTLVAFPSSSVYPTkdeennPLE 185
Cdd:smart00350   1 KPSSIRELRADHLGKLVRISGIVTRTSGVRPKLKRAsftCEKCGATLGPEIQSGRETEPTVCPPRECQSPT------PFS 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927  186 TEYGLSVYKDHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKAKPGDRVQVVGTYRCLP-GKKGGYTSGT--FRTVLIA 262
Cdd:smart00350  75 LNHERSTFIDFQKIKLQESPEEVPVGQLPRSVDVILDGDLVDKAKPGDRVEVTGIYRNVPyGFKLNTVKGLpvFATYIEA 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927  263 CNVK----QMSKDAQP----SFSAEDIAKIKKFSKtrSKDIFDQLAKSLAPSIHGHDYVKKAILCLLLGGVERDLENGSH 334
Cdd:smart00350 155 NHVRkldyKRSFEDSSfsvqSLSDEEEEEIRKLSK--DPDIYERLARSLAPSIYGHEDIKKAILLLLFGGVHKNLPDGMK 232

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927  335 IRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKM 414
Cdd:smart00350 233 IRGDINILLCGDPGTAKSQLLKYVEKTAPRAVYTTGKGSSAVGLTAAVTRDPETREFTLEAGALVLADNGVCCIDEFDKM 312

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927  415 SDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQD 494
Cdd:smart00350 313 DDSDRTAIHEAMEQQTISIAKAGITTTLNARCSVLAAANPIGGRYDPKLTPEENIDLPAPILSRFDLLFVVLDEVDEERD 392

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927  495 REISDHVLRMHRYRAPgeqdgdamplgsavdilatddpnfsQEDQQDtqiyekhdnllhgtkkkkqvvrcgremeftvcg 574
Cdd:smart00350 393 RELAKHVVDLHRYSHP-------------------------EEDEAF--------------------------------- 414

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927  575 srEKMVSAAFMKKYIHVAK-IIKPVLTQESATYIAEEYSRLRSQDSmSSDTARTSPVTARTLETLIRLATAHAKARMSKT 653
Cdd:smart00350 415 --EPPLSQEKLRKYIAYAReKIKPKLSEEAADKLVKAYVDLRKEDS-QTESRSSIPITVRQLESIIRLSEAHAKMRLSDV 491

                          570
                   ....*....|....*...
gi 1484505927  654 VDLQDAEEAVELVQYAYF 671
Cdd:smart00350 492 VEEADVEEAIRLLRESII 509
MCM3 cd17754
DNA replication licensing factor Mcm3; Mcm3 is a helicase that play an important role in ...
 298-669 0e+00

DNA replication licensing factor Mcm3; Mcm3 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350660 [Multi-domain]  Cd Length: 299  Bit Score: 587.51  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 298 QLAKSLAPSIHGHDYVKKAILCLLLGGVERDLENGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGVG 377
Cdd:cd17754     1 LLSKSLAPSIYGHEYIKKAILLMLLGGVEKNLENGSHLRGDINILLVGDPSVAKSQLLRYVLNTAPLAIATTGRGSSGVG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 378 LTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYG 457
Cdd:cd17754    81 LTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDIDRVAIHEVMEQQTVTIAKAGIHASLNARCSVLAAANPVYG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 458 RYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHRYrapgeqdgdamplgsavdilatddpnfsqe 537
Cdd:cd17754   161 RYDVYKTPMENIGLPDSLLSRFDLLFIVLDDIDEERDRSISEHVLRMHRY------------------------------ 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 538 dqqdtqiyekhdnllhgtkkkkqvvrcgremeftvcgsrekmvsAAFMKKYIHVAK-IIKPVLTQESATYIAEEYSRLRS 616
Cdd:cd17754   211 --------------------------------------------IKFLRKYIHYAKeRIKPKLTQEAAEYIAEEYADLRN 246

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1484505927 617 QDSMSSDTARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYA 669
Cdd:cd17754   247 DDNTKTDKARTSPITARTLETLIRLATAHAKARLSKTVDKVDAEVALNLLRFA 299
Mcm2 COG1241
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ...
 19-668 3.81e-178

DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];


Pssm-ID: 440854 [Multi-domain]  Cd Length: 682  Bit Score: 528.22  E-value: 3.81e-178
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927  19 YLDFLDDEEdqgiYQSKVRELISDNQYR--LIVNVNDLRRKNEKRANRLLNNAFEELVAFQRALKDFVASIdatYAKQYE 96
Cdd:COG1241     9 FEEFLRRYK----YRDEILELAQEYPEKrsLVVDYNDLYSFDPDLADDLLENPDEVLEAAEEALREIDLEP---YDVSLG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927  97 EFYVGLEGSFgsKHVSPRTLTSCFLSCVVCVEGIVTKCSLVRPKVVRSVHYCPA--TKKTIERRYSDLTtlvafpsssvY 174
Cdd:COG1241    82 DAHVRITNLP--ETVPIRDIRSDHIGKLISVEGIVRKATEVKPKITEAAFECPRcgTETYVPQTGEKLQ----------E 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 175 PTKDEE---NNPLETEYGLSVYKDHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKAKPGDRVQVVGTYRCLPGKKGGY 251
Cdd:COG1241   150 PHECPGcgrQGPFKLLPEKSEFIDAQKIRIQEPPEDLPGGQQPQSIDVILEDDLVGEVRPGDRVTVTGILRIEQRTSGRG 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 252 TSGTFRTVLIACNVKQMSKD-AQPSFSAEDIAKIKKFSKtrSKDIFDQLAKSLAPSIHGHDYVKKAILCLLLGGVERDLE 330
Cdd:COG1241   230 KSTIFDLYLEANSIEVEEKEfEEIEITEEDEEKIKELSK--DPDIYEKIIASIAPSIYGYEEIKEAIALQLFGGVPKVLP 307

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 331 NGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGVGLTAAVTTDQE-TGERRLEAGAMVLADRGVVCID 409
Cdd:COG1241   308 DGSRIRGDIHILLVGDPGTAKSQLLRYAARLAPRGVYTSGKGSTAAGLTAAAVRDDFgTGRWTLEAGALVLADGGLACID 387

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 410 EFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQM 489
Cdd:COG1241   388 ELDKMREEDRSALHEAMEQQTISIAKAGIVATLNARCSVLAAANPKYGRFDPYEPIAEQIDLPPTLLSRFDLIFVLRDKP 467

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 490 DPEQDREISDHVLRMHRyrapgeqdgdamplgsAVDILATDDPNFSQEDqqdtqiyekhdnllhgtkkkkqvvrcgreme 569
Cdd:COG1241   468 DEERDRELARHILKVHR----------------AGELLEQEIEEETEEV------------------------------- 500

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 570 ftvcgsrEKMVSAAFMKKYIHVAK-IIKPVLTQESATYIAEEYSRLRSQDSMSSDTArtsPVTARTLETLIRLATAHAKA 648
Cdd:COG1241   501 -------KPEIDPDLLRKYIAYARrNVFPVLTEEAKDLIEDFYVDMRKKGEDEDSPV---PITARQLEALIRLAEASARM 570

                         650       660
                  ....*....|....*....|
gi 1484505927 649 RMSKTVDLQDAEEAVELVQY 668
Cdd:COG1241   571 RLSDTVTEEDAERAIRLVDS 590
minchrom_main_MCM NF040949
minichromosome maintenance protein MCM;
12-668 3.00e-167

minichromosome maintenance protein MCM;


Pssm-ID: 468880 [Multi-domain]  Cd Length: 681  Bit Score: 500.22  E-value: 3.00e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927  12 LREAQRDYLDFLDDEEDQGIYQSKVRELISDNQYRLIVNVNDLRRKNEKRANRLLNNAFEELVAFQRALKDFVASIDATY 91
Cdd:NF040949    1 LGEKFKEFIRTFRDSFGNEKYKERIFEMIAMRKRSLVVDFNDLYMFDPELADLLIEKPDEVLPAASKALKEIVEEEDPEY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927  92 AKQYEEFYVGLEGSFgsKHVSPRTLTSCFLSCVVCVEGIVTKCSLVRPKVVRSVHYCPATKKTIERRYSDLTTLVAFPSS 171
Cdd:NF040949   81 AEEVAKFHVRFRNLP--RTVPLRDLRSEYIGKLIAVEGIVTRTTPVKPRIVKAVFRCRDCGCEFEWPEEEEESYEIVEPP 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 172 SVYPtKDEENNPLETEYGLSVYKDHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKAKPGDRVQVVGTYRCLPG---KK 248
Cdd:NF040949  159 TVCP-VCGKPGSFRLLQEKSKFIDWQKIVVQERPEELPPGQLPRSIEVVLEDDLVDTARPGDRVTVTGILRIKPDsslKK 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 249 GgyTSGTFRTVLIACNVKQMSKD-AQPSFSAEDIAKIKKFSKtrSKDIFDQLAKSLAPSIHGHDYVKKAILCLLLGGVER 327
Cdd:NF040949  238 G--SRPIFKNYIEANHIEVSQKElEEVEITEEDEEKILELAK--DPWIREKIIASIAPSIYGHWEIKEAIALLLFGGVPK 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 328 DLENGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVC 407
Cdd:NF040949  314 VLPDGTRIRGDIHVLIVGDPGTAKSQLLQYVARLAPRAVYTSGKGSTAAGLTAAVVRDKLTGEYYLEAGALVLADGGVAV 393

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 408 IDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLD 487
Cdd:NF040949  394 IDEIDKMREEDRSAIHEAMEQQTVSIAKAGIVATLNARASVLAAGNPKFGRYDPNRSVAENIDLPPTILSRFDLIFVIRD 473

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 488 QMDPEQDREISDHVLRMHRyrapgeqdgdamplgsavdilatddpnfsqedqqdtqiyekhdnllhGTKKKKQVVRcgre 567
Cdd:NF040949  474 KPNEERDRRLARHILDVHS-----------------------------------------------GKEKVKPEID---- 502

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 568 meftvcgsrekmvsAAFMKKYIHVA-KIIKPVLTQESATYIAEEYSRLRSQDSMSSDTARTSPVTARTLETLIRLATAHA 646
Cdd:NF040949  503 --------------PDLLKKYIAYArKYVRPKLTEEAKKLIEDFYVEMRKSSKSSEDPDSPIPITARQLEALIRLSEAHA 568

                         650       660
                  ....*....|....*....|..
gi 1484505927 647 KARMSKTVDLQDAEEAVELVQY 668
Cdd:NF040949  569 KMRLKDEVTAEDAERAIRLMLA 590
MCM pfam00493
MCM P-loop domain;
280-505 3.96e-129

MCM P-loop domain;


Pssm-ID: 459830 [Multi-domain]  Cd Length: 224  Bit Score: 384.96  E-value: 3.96e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 280 DIAKIKKFSKtrSKDIFDQLAKSLAPSIHGHDYVKKAILCLLLGGVERDLENGSHIRGDINILLIGDPSVAKSQLLRYVL 359
Cdd:pfam00493   1 DEEEIKELAK--RPDIYDKLADSIAPSIYGHEDVKKAILLQLFGGVKKILPDGTRLRGDINVLLVGDPGTAKSQLLKYVE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 360 CTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIH 439
Cdd:pfam00493  79 KIAPRAVYTSGKGSSAAGLTAAVVRDPVTGEFVLEAGALVLADGGVCCIDEFDKMNDEDRVALHEAMEQQTISIAKAGIV 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1484505927 440 ARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMH 505
Cdd:pfam00493 159 ATLNARCSILAAANPIFGRYDPKKSIAENINLPPPLLSRFDLIFVLLDKPDEEKDERLAKHIVDLH 224
PTZ00111 PTZ00111
DNA replication licensing factor MCM4; Provisional
 113-671 1.07e-77

DNA replication licensing factor MCM4; Provisional


Pssm-ID: 173403 [Multi-domain]  Cd Length: 915  Bit Score: 270.33  E-value: 1.07e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 113 PRTLTSCFLSCVVCVEGIVTKCSLVRPKVVRSVHYCPATKKTIERRYSDLTTLVafpssSVYPTKDEENNPL-------- 184
Cdd:PTZ00111  218 VGNLEPSMADSLVQFSGTVVRQTWIVPEITMACFRCRGQKKIGLNDYQPCTCEH-----YEYVIQGEVNEPLlcnecnsk 292

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 185 ---ETEYGLSVYKDHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDK--------------------AKPGDRVQVVGTY 241
Cdd:PTZ00111  293 ytfELNHNMCVYSTKKIVKLLQSNSSLNNPDKDGLDNSVDNSGLNGEiymkdnevinlnlyddlidsVKTGDRVTVVGIL 372

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 242 RCLPGKkggyTSGTFRTV---------LIACNVKQMSKDAQP-----------SFSAEDIAKIKKFSktRSKDIFDQLAK 301
Cdd:PTZ00111  373 KVTPIR----TSTTRRTLkslytyfvnVIHVKVINSTNANQPekglkylgnenDFSDLQVYKILELS--RNPMIYRILLD 446

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 302 SLAPSIHGHDYVKKAILCLLLGGVERDLENGSHI---------RGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRG 372
Cdd:PTZ00111  447 SFAPSIKARNNVKIGLLCQLFSGNKNSSDFNKSPdacykvdnfRGIINVLLCGDPGTAKSQLLHYTHLLSPRSIYTSGKS 526

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 373 SSGVGLTAAVT-TDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAA 451
Cdd:PTZ00111  527 SSSVGLTASIKfNESDNGRAMIQPGAVVLANGGVCCIDELDKCHNESRLSLYEVMEQQTVTIAKAGIVATLKAETAILAS 606

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 452 ANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRmhryrapgeqdgdAMPLGSAVDILATDD 531
Cdd:PTZ00111  607 CNPINSRYNKNKAVIENINISPSLFTRFDLIYLVLDHIDQDTDQLISLSIAK-------------DFLLPHMTGSGNDED 673

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 532 PnfsqEDQQDTQIYEkhdnllhgtkkkKQVVRCGREMeftvcgsreKMVSAAFMKKYIHVAKI-IKPVLTQESATYIAEE 610
Cdd:PTZ00111  674 T----YDRSNTMHVE------------DESLRSEKDY---------NKNDLDMLRMYIKFSKLhCFPKLSDEAKKVITRE 728

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 611 YSRLRSQDSMSSDT--------------------ARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYAY 670
Cdd:PTZ00111  729 YVKMRQGNFQTSNLdelehaqedddddlyyqssgTRMIYVSSRMISSIIRISVSLARMRLSTVVTPADALQAVQIVKSST 808


                  .
gi 1484505927 671 F 671
Cdd:PTZ00111  809 F 809
MCM_N pfam14551
MCM N-terminal domain; This family contains the N-terminal domain of MCM proteins.
 16-104 9.90e-17

MCM N-terminal domain; This family contains the N-terminal domain of MCM proteins.


Pssm-ID: 464206 [Multi-domain]  Cd Length: 95  Bit Score: 76.18  E-value: 9.90e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927  16 QRDYLDFLD----DEEDQGIYQSKVRELISDNQYRLIVNVNDLRRKNEKRANRLLNNAFEELVAFQRALKDFVASI--DA 89
Cdd:pfam14551   1 KRKFKDFLEefreDGDGEFKYRDQLREMIEREQRSLEVDLDDLREFDPDLAEALLENPYEYLPLFEEALKEVVKELseDP 80

                          90
                  ....*....|....*
gi 1484505927  90 TYAKQYEEFYVGLEG 104
Cdd:pfam14551  81 DYAEEEKEFQVRFYN 95
 
Name Accession Description Interval E-value
MCM smart00350
minichromosome maintenance proteins;
109-671 0e+00

minichromosome maintenance proteins;


Pssm-ID: 214631 [Multi-domain]  Cd Length: 509  Bit Score: 734.84  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927  109 KHVSPRTLTSCFLSCVVCVEGIVTKCSLVRPKVVRS---VHYCPATKKTIERRYSDLTTLVAFPSSSVYPTkdeennPLE 185
Cdd:smart00350   1 KPSSIRELRADHLGKLVRISGIVTRTSGVRPKLKRAsftCEKCGATLGPEIQSGRETEPTVCPPRECQSPT------PFS 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927  186 TEYGLSVYKDHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKAKPGDRVQVVGTYRCLP-GKKGGYTSGT--FRTVLIA 262
Cdd:smart00350  75 LNHERSTFIDFQKIKLQESPEEVPVGQLPRSVDVILDGDLVDKAKPGDRVEVTGIYRNVPyGFKLNTVKGLpvFATYIEA 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927  263 CNVK----QMSKDAQP----SFSAEDIAKIKKFSKtrSKDIFDQLAKSLAPSIHGHDYVKKAILCLLLGGVERDLENGSH 334
Cdd:smart00350 155 NHVRkldyKRSFEDSSfsvqSLSDEEEEEIRKLSK--DPDIYERLARSLAPSIYGHEDIKKAILLLLFGGVHKNLPDGMK 232

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927  335 IRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKM 414
Cdd:smart00350 233 IRGDINILLCGDPGTAKSQLLKYVEKTAPRAVYTTGKGSSAVGLTAAVTRDPETREFTLEAGALVLADNGVCCIDEFDKM 312

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927  415 SDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQD 494
Cdd:smart00350 313 DDSDRTAIHEAMEQQTISIAKAGITTTLNARCSVLAAANPIGGRYDPKLTPEENIDLPAPILSRFDLLFVVLDEVDEERD 392

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927  495 REISDHVLRMHRYRAPgeqdgdamplgsavdilatddpnfsQEDQQDtqiyekhdnllhgtkkkkqvvrcgremeftvcg 574
Cdd:smart00350 393 RELAKHVVDLHRYSHP-------------------------EEDEAF--------------------------------- 414

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927  575 srEKMVSAAFMKKYIHVAK-IIKPVLTQESATYIAEEYSRLRSQDSmSSDTARTSPVTARTLETLIRLATAHAKARMSKT 653
Cdd:smart00350 415 --EPPLSQEKLRKYIAYAReKIKPKLSEEAADKLVKAYVDLRKEDS-QTESRSSIPITVRQLESIIRLSEAHAKMRLSDV 491

                          570
                   ....*....|....*...
gi 1484505927  654 VDLQDAEEAVELVQYAYF 671
Cdd:smart00350 492 VEEADVEEAIRLLRESII 509
MCM3 cd17754
DNA replication licensing factor Mcm3; Mcm3 is a helicase that play an important role in ...
 298-669 0e+00

DNA replication licensing factor Mcm3; Mcm3 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350660 [Multi-domain]  Cd Length: 299  Bit Score: 587.51  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 298 QLAKSLAPSIHGHDYVKKAILCLLLGGVERDLENGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGVG 377
Cdd:cd17754     1 LLSKSLAPSIYGHEYIKKAILLMLLGGVEKNLENGSHLRGDINILLVGDPSVAKSQLLRYVLNTAPLAIATTGRGSSGVG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 378 LTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYG 457
Cdd:cd17754    81 LTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDIDRVAIHEVMEQQTVTIAKAGIHASLNARCSVLAAANPVYG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 458 RYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHRYrapgeqdgdamplgsavdilatddpnfsqe 537
Cdd:cd17754   161 RYDVYKTPMENIGLPDSLLSRFDLLFIVLDDIDEERDRSISEHVLRMHRY------------------------------ 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 538 dqqdtqiyekhdnllhgtkkkkqvvrcgremeftvcgsrekmvsAAFMKKYIHVAK-IIKPVLTQESATYIAEEYSRLRS 616
Cdd:cd17754   211 --------------------------------------------IKFLRKYIHYAKeRIKPKLTQEAAEYIAEEYADLRN 246

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1484505927 617 QDSMSSDTARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYA 669
Cdd:cd17754   247 DDNTKTDKARTSPITARTLETLIRLATAHAKARLSKTVDKVDAEVALNLLRFA 299
Mcm2 COG1241
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ...
 19-668 3.81e-178

DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];


Pssm-ID: 440854 [Multi-domain]  Cd Length: 682  Bit Score: 528.22  E-value: 3.81e-178
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927  19 YLDFLDDEEdqgiYQSKVRELISDNQYR--LIVNVNDLRRKNEKRANRLLNNAFEELVAFQRALKDFVASIdatYAKQYE 96
Cdd:COG1241     9 FEEFLRRYK----YRDEILELAQEYPEKrsLVVDYNDLYSFDPDLADDLLENPDEVLEAAEEALREIDLEP---YDVSLG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927  97 EFYVGLEGSFgsKHVSPRTLTSCFLSCVVCVEGIVTKCSLVRPKVVRSVHYCPA--TKKTIERRYSDLTtlvafpsssvY 174
Cdd:COG1241    82 DAHVRITNLP--ETVPIRDIRSDHIGKLISVEGIVRKATEVKPKITEAAFECPRcgTETYVPQTGEKLQ----------E 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 175 PTKDEE---NNPLETEYGLSVYKDHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKAKPGDRVQVVGTYRCLPGKKGGY 251
Cdd:COG1241   150 PHECPGcgrQGPFKLLPEKSEFIDAQKIRIQEPPEDLPGGQQPQSIDVILEDDLVGEVRPGDRVTVTGILRIEQRTSGRG 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 252 TSGTFRTVLIACNVKQMSKD-AQPSFSAEDIAKIKKFSKtrSKDIFDQLAKSLAPSIHGHDYVKKAILCLLLGGVERDLE 330
Cdd:COG1241   230 KSTIFDLYLEANSIEVEEKEfEEIEITEEDEEKIKELSK--DPDIYEKIIASIAPSIYGYEEIKEAIALQLFGGVPKVLP 307

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 331 NGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGVGLTAAVTTDQE-TGERRLEAGAMVLADRGVVCID 409
Cdd:COG1241   308 DGSRIRGDIHILLVGDPGTAKSQLLRYAARLAPRGVYTSGKGSTAAGLTAAAVRDDFgTGRWTLEAGALVLADGGLACID 387

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 410 EFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQM 489
Cdd:COG1241   388 ELDKMREEDRSALHEAMEQQTISIAKAGIVATLNARCSVLAAANPKYGRFDPYEPIAEQIDLPPTLLSRFDLIFVLRDKP 467

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 490 DPEQDREISDHVLRMHRyrapgeqdgdamplgsAVDILATDDPNFSQEDqqdtqiyekhdnllhgtkkkkqvvrcgreme 569
Cdd:COG1241   468 DEERDRELARHILKVHR----------------AGELLEQEIEEETEEV------------------------------- 500

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 570 ftvcgsrEKMVSAAFMKKYIHVAK-IIKPVLTQESATYIAEEYSRLRSQDSMSSDTArtsPVTARTLETLIRLATAHAKA 648
Cdd:COG1241   501 -------KPEIDPDLLRKYIAYARrNVFPVLTEEAKDLIEDFYVDMRKKGEDEDSPV---PITARQLEALIRLAEASARM 570

                         650       660
                  ....*....|....*....|
gi 1484505927 649 RMSKTVDLQDAEEAVELVQY 668
Cdd:COG1241   571 RLSDTVTEEDAERAIRLVDS 590
minchrom_main_MCM NF040949
minichromosome maintenance protein MCM;
12-668 3.00e-167

minichromosome maintenance protein MCM;


Pssm-ID: 468880 [Multi-domain]  Cd Length: 681  Bit Score: 500.22  E-value: 3.00e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927  12 LREAQRDYLDFLDDEEDQGIYQSKVRELISDNQYRLIVNVNDLRRKNEKRANRLLNNAFEELVAFQRALKDFVASIDATY 91
Cdd:NF040949    1 LGEKFKEFIRTFRDSFGNEKYKERIFEMIAMRKRSLVVDFNDLYMFDPELADLLIEKPDEVLPAASKALKEIVEEEDPEY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927  92 AKQYEEFYVGLEGSFgsKHVSPRTLTSCFLSCVVCVEGIVTKCSLVRPKVVRSVHYCPATKKTIERRYSDLTTLVAFPSS 171
Cdd:NF040949   81 AEEVAKFHVRFRNLP--RTVPLRDLRSEYIGKLIAVEGIVTRTTPVKPRIVKAVFRCRDCGCEFEWPEEEEESYEIVEPP 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 172 SVYPtKDEENNPLETEYGLSVYKDHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKAKPGDRVQVVGTYRCLPG---KK 248
Cdd:NF040949  159 TVCP-VCGKPGSFRLLQEKSKFIDWQKIVVQERPEELPPGQLPRSIEVVLEDDLVDTARPGDRVTVTGILRIKPDsslKK 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 249 GgyTSGTFRTVLIACNVKQMSKD-AQPSFSAEDIAKIKKFSKtrSKDIFDQLAKSLAPSIHGHDYVKKAILCLLLGGVER 327
Cdd:NF040949  238 G--SRPIFKNYIEANHIEVSQKElEEVEITEEDEEKILELAK--DPWIREKIIASIAPSIYGHWEIKEAIALLLFGGVPK 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 328 DLENGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVC 407
Cdd:NF040949  314 VLPDGTRIRGDIHVLIVGDPGTAKSQLLQYVARLAPRAVYTSGKGSTAAGLTAAVVRDKLTGEYYLEAGALVLADGGVAV 393

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 408 IDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLD 487
Cdd:NF040949  394 IDEIDKMREEDRSAIHEAMEQQTVSIAKAGIVATLNARASVLAAGNPKFGRYDPNRSVAENIDLPPTILSRFDLIFVIRD 473

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 488 QMDPEQDREISDHVLRMHRyrapgeqdgdamplgsavdilatddpnfsqedqqdtqiyekhdnllhGTKKKKQVVRcgre 567
Cdd:NF040949  474 KPNEERDRRLARHILDVHS-----------------------------------------------GKEKVKPEID---- 502

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 568 meftvcgsrekmvsAAFMKKYIHVA-KIIKPVLTQESATYIAEEYSRLRSQDSMSSDTARTSPVTARTLETLIRLATAHA 646
Cdd:NF040949  503 --------------PDLLKKYIAYArKYVRPKLTEEAKKLIEDFYVEMRKSSKSSEDPDSPIPITARQLEALIRLSEAHA 568

                         650       660
                  ....*....|....*....|..
gi 1484505927 647 KARMSKTVDLQDAEEAVELVQY 668
Cdd:NF040949  569 KMRLKDEVTAEDAERAIRLMLA 590
MCM cd17706
MCM helicase family; MCM helicases are a family of helicases that play an important role in ...
 299-667 2.06e-139

MCM helicase family; MCM helicases are a family of helicases that play an important role in replication and homologous recombination repair. The heterohexameric ring-shaped Mcm2-7 complex is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases. Mcm8 and Mcm9, form a complex required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350658 [Multi-domain]  Cd Length: 311  Bit Score: 414.82  E-value: 2.06e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 299 LAKSLAPSIHGHDYVKKAILCLLLGGVERDLENGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGVGL 378
Cdd:cd17706     2 LADSIAPSIYGHEDVKKAVLLQLFGGVQKILEDGTRIRGDIHILLVGDPGTAKSQILKYVLKIAPRGVYTSGKGSSGAGL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 379 TAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYGR 458
Cdd:cd17706    82 TAAVVRDSETGEWYLEAGALVLADGGVCCIDEFDKMKELDRTALHEAMEQQTISIAKAGIVTTLNARCSILAAANPKGGR 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 459 YDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHRYRAPGEQDGDamplgsavdilatddpnfsqed 538
Cdd:cd17706   162 YNPKLSPIENINLPSPLLSRFDLIFVIRDDPDEERDEELAEHIIDLHRGSDPEEQVKP---------------------- 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 539 qqdtqiyekhdnllhgtkkkkqvvrcgremeftvcGSREKMVSAAFMKKYIHVAKIIKPVLTQESATYIAEEYSRLRSQd 618
Cdd:cd17706   220 -----------------------------------EEDGIPIDIELLRKYILYARQIHPKISEEAREKLVRWYVELRKE- 263

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 1484505927 619 smsSDTARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQ 667
Cdd:cd17706   264 ---SERRSTIPITARQLESVIRLAEAHAKMRLSEVVTEEDVEEAIRLVR 309
MCM pfam00493
MCM P-loop domain;
280-505 3.96e-129

MCM P-loop domain;


Pssm-ID: 459830 [Multi-domain]  Cd Length: 224  Bit Score: 384.96  E-value: 3.96e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 280 DIAKIKKFSKtrSKDIFDQLAKSLAPSIHGHDYVKKAILCLLLGGVERDLENGSHIRGDINILLIGDPSVAKSQLLRYVL 359
Cdd:pfam00493   1 DEEEIKELAK--RPDIYDKLADSIAPSIYGHEDVKKAILLQLFGGVKKILPDGTRLRGDINVLLVGDPGTAKSQLLKYVE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 360 CTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIH 439
Cdd:pfam00493  79 KIAPRAVYTSGKGSSAAGLTAAVVRDPVTGEFVLEAGALVLADGGVCCIDEFDKMNDEDRVALHEAMEQQTISIAKAGIV 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1484505927 440 ARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMH 505
Cdd:pfam00493 159 ATLNARCSILAAANPIFGRYDPKKSIAENINLPPPLLSRFDLIFVLLDKPDEEKDERLAKHIVDLH 224
MCM7 cd17758
DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in ...
 299-669 3.65e-121

DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350664 [Multi-domain]  Cd Length: 306  Bit Score: 367.50  E-value: 3.65e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 299 LAKSLAPSIHGHDYVKKAILCLLLGGVERDlENGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGVGL 378
Cdd:cd17758     2 LAASIAPEIYGHEDVKKALLLLLVGGVDKR-GDGMKIRGDINICLMGDPGVAKSQLLKYICRIAPRSVYTTGRGSSGVGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 379 TAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYGR 458
Cdd:cd17758    81 TAAVMKDPVTGEMTLEGGALVLADQGICCIDEFDKMDESDRTAIHEVMEQQTISIAKAGITTTLNARTSILAAANPAYGR 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 459 YDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHryrapgeQDGDAMPlgSAVDILatdDPNfsqed 538
Cdd:cd17758   161 YNPRRSPEQNINLPAALLSRFDLLFLILDKPDRDNDLRLAEHVTYVH-------QHNKQPD--SDFEPL---DPK----- 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 539 qqdtqiyekhdnllhgtkkkkqvvrcgremeftvcgsrekmvsaaFMKKYIHVAKIIKPVLTQESATYIAEEYSRLRSQD 618
Cdd:cd17758   224 ---------------------------------------------LLRAYIALAKRKRPTVPPALADYIVQAYVEMRQEA 258

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1484505927 619 SMSSDTARTSPvtaRTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYA 669
Cdd:cd17758   259 KRSKDFTFTTP---RTLLAILRLSQALARLRLSDSVEIDDVEEALRLMEMS 306
MCM5 cd17756
DNA replication licensing factor Mcm5; Mcm5 is a helicase that play an important role in ...
 299-667 2.64e-116

DNA replication licensing factor Mcm5; Mcm5 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350662 [Multi-domain]  Cd Length: 317  Bit Score: 355.54  E-value: 2.64e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 299 LAKSLAPSIHGHDYVKKAILCLLLGGVERDLENGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGVGL 378
Cdd:cd17756     2 ISKSIAPSIYGNEDIKKAIACLLFGGSRKRLPDGMRLRGDINVLLLGDPGTAKSQLLKFVEKVAPIGVYTSGKGSSAAGL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 379 TAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYGR 458
Cdd:cd17756    82 TASVMRDPSTREFYLEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRTSVLAAANPVFGR 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 459 YDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHryrapgeqdgdamplgsavdilatddpnfsqed 538
Cdd:cd17756   162 YDDLKTPGDNIDFQTTILSRFDMIFIVKDKHDEERDITIAKHVINIH--------------------------------- 208

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 539 qqdtqiyekhdnllhgTKKKKQVVRCGREMEFTVcgsrekmvsaAFMKKYIHVAKI-IKPVLTQESATYIAEEYSRLRS- 616
Cdd:cd17756   209 ----------------ASARKASQSQENEGEIPI----------SKLKRYIAYCRAkCAPRLSEEAAEKLSNHYVTIRKd 262

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1484505927 617 --QDSMSSDTARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQ 667
Cdd:cd17756   263 vrQNELESDNRSSIPITVRQLEAIIRISESLAKMELSPIATEKHVEEAIRLFQ 315
MCM6 cd17757
DNA replication licensing factor Mcm6; Mcm6 is a helicase that play an important role in ...
 299-666 4.20e-114

DNA replication licensing factor Mcm6; Mcm6 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350663 [Multi-domain]  Cd Length: 307  Bit Score: 349.36  E-value: 4.20e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 299 LAKSLAPSIHGHDYVKKAILCLLLGGVERDLENGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGVGL 378
Cdd:cd17757     2 LVRSIAPSIYGHEEVKKGILLMLLGGVHKITREGISLRGDINVCIVGDPSTAKSQFLKYVEEFSPRAVYTSGKASSAAGL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 379 TAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYGR 458
Cdd:cd17757    82 TAAVVRDEETGDFVIEAGALMLADNGICCIDEFDKMDIKDQVAIHEAMEQQTISITKAGIQATLNARTSILAAANPVGGR 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 459 YDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHRYRApgeqdgDAMplgsavdilatdDPNFSQED 538
Cdd:cd17757   162 YDRSKSLKQNINISAPIMSRFDLFFVLLDECNEVTDYAIASHIVDLHSKRE------EAI------------EPPFTAEQ 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 539 qqdtqiyekhdnllhgtkkkkqvvrcgremeftvcgsrekmvsaafMKKYIHVAKIIKPVLTQESATYIAEEYSRLRsQD 618
Cdd:cd17757   224 ----------------------------------------------LKRYIAYARTFKPKLTKEAKDELVEQYKELR-QD 256

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 1484505927 619 SMSSDTARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELV 666
Cdd:cd17757   257 DASGSTRSSYRITVRQLESLIRLSEAIARLHCSDEVTPEHVEEAARLL 304
MCM_arch cd17761
archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the ...
 297-667 2.78e-110

archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the eukaryotic Mcm2-7 helicase and also function as the replicative helicase at the replication fork


Pssm-ID: 350667 [Multi-domain]  Cd Length: 308  Bit Score: 339.43  E-value: 2.78e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 297 DQLAKSLAPSIHGHDYVKKAILCLLLGGVERDLENGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGV 376
Cdd:cd17761     1 EKIISSIAPSIYGHEDVKEAIALQLFGGVPKVLPDGTRIRGDIHILLVGDPGTAKSQLLKYVSKVAPRAVYTTGKGSTAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 377 GLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVY 456
Cdd:cd17761    81 GLTAAVVRDEGTGEWYLEAGALVLADKGIAVVDEIDKMRKEDRSALHEAMEQQTISIAKAGIVATLNARAAVLAAANPKF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 457 GRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHRyrapgeqdgdamplgsavdilatddpnfsq 536
Cdd:cd17761   161 GRFDSYRPVAEQIDLPPTLLSRFDLIFVLKDTPNEEKDRRLANHILDTHS------------------------------ 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 537 edqqdtqiyekhdnllhgtkkkkqvvrcGREMEftvcgSREKMVSAAFMKKYIHVA-KIIKPVLTQESATYIAEEYSRLR 615
Cdd:cd17761   211 ----------------------------GGEMR-----EIKPEIDPDLLRKYIAYArKNVRPVLTEEAKQLIKDFYVEMR 257

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1484505927 616 SQdsmSSDTARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQ 667
Cdd:cd17761   258 KS---GQETPSPVPITARQLEALVRLSEASARMRLSQEVTLEDAERAIRIML 306
MCM4 cd17755
DNA replication licensing factor Mcm4; Mcm4 is a helicase that play an important role in ...
 299-669 4.04e-107

DNA replication licensing factor Mcm4; Mcm4 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350661 [Multi-domain]  Cd Length: 309  Bit Score: 331.32  E-value: 4.04e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 299 LAKSLAPSIHGHDYVKKAILCLLLGGVERDLEN-GSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGVG 377
Cdd:cd17755     2 LARSIAPSIYELEDVKKGILLQLFGGTRKDFTKtGGKYRGDINILLCGDPGTSKSQLLQYVHKISPRGVYTSGKGSSAVG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 378 LTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYG 457
Cdd:cd17755    82 LTAYVTRDPDTKQLVLESGALVLSDGGICCIDEFDKMSDSTRSVLHEVMEQQTLSIAKAGIITTLNARTSILASANPIGS 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 458 RYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHryrapgeqdgdamplgsavdilatddpnfsqe 537
Cdd:cd17755   162 RYNPKLTVVENIDLPPTLLSRFDLIYLVLDKVDEKYDRRLAKHLVSLY-------------------------------- 209

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 538 dQQDTQIYEKHDnllhgtkkkkqvvrcgremeftvcgsrekMVSAAFMKKYIHVAKI-IKPVLTQESATYIAEEYSRLRs 616
Cdd:cd17755   210 -LEDTPEHIQDE-----------------------------VLDVEVLTDYISYAREhIHPKLSEEAAQELVQAYVDMR- 258

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1484505927 617 qdSMSSDTARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYA 669
Cdd:cd17755   259 --KMGSDARKRITATPRQLESLIRLAEAHAKMRLSNVVEAEDVEEAVRLIREA 309
MCM2 cd17753
DNA replication licensing factor Mcm2; Mcm2 is a helicase that play an important role in ...
 301-666 1.13e-104

DNA replication licensing factor Mcm2; Mcm2 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350659 [Multi-domain]  Cd Length: 325  Bit Score: 325.56  E-value: 1.13e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 301 KSLAPSIHGHDYVKKAILCLLLGGVERDLENGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGVGLTA 380
Cdd:cd17753     4 NSIAPSIYGHDDIKTAIALALFGGVAKNPGGKHRIRGDINVLLLGDPGTAKSQFLKYVEKTAHRAVFTTGQGASAVGLTA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 381 AVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYGRYD 460
Cdd:cd17753    84 SVRKDPVTKEWTLEGGALVLADKGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCSVIAAANPIGGRYN 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 461 QYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHRYRAPgeqdgdamplgsavdilatddpnfsQEDQQ 540
Cdd:cd17753   164 PTLTFAQNVNLTEPILSRFDILCVVRDTVDPEEDERLAKFVVGSHVRSHP-------------------------ENDED 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 541 DTQIYEKHDNLLHGTKKkkqvvrcgremeftvcgsrEKMVSAAFMKKYIHVAKI-IKPVLTQESATYIAEEYSRLRsQDS 619
Cdd:cd17753   219 REGEEEKNQRQRPKETK-------------------VEPIPQELLRKYIHYAREkVRPKLNQMDMDKVSRVYADLR-KES 278

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 1484505927 620 MSSDTArtsPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELV 666
Cdd:cd17753   279 MATGSL---PITVRHLESIIRISEAHAKMHLREYVSEEDVDMAIRVM 322
PTZ00111 PTZ00111
DNA replication licensing factor MCM4; Provisional
 113-671 1.07e-77

DNA replication licensing factor MCM4; Provisional


Pssm-ID: 173403 [Multi-domain]  Cd Length: 915  Bit Score: 270.33  E-value: 1.07e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 113 PRTLTSCFLSCVVCVEGIVTKCSLVRPKVVRSVHYCPATKKTIERRYSDLTTLVafpssSVYPTKDEENNPL-------- 184
Cdd:PTZ00111  218 VGNLEPSMADSLVQFSGTVVRQTWIVPEITMACFRCRGQKKIGLNDYQPCTCEH-----YEYVIQGEVNEPLlcnecnsk 292

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 185 ---ETEYGLSVYKDHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDK--------------------AKPGDRVQVVGTY 241
Cdd:PTZ00111  293 ytfELNHNMCVYSTKKIVKLLQSNSSLNNPDKDGLDNSVDNSGLNGEiymkdnevinlnlyddlidsVKTGDRVTVVGIL 372

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 242 RCLPGKkggyTSGTFRTV---------LIACNVKQMSKDAQP-----------SFSAEDIAKIKKFSktRSKDIFDQLAK 301
Cdd:PTZ00111  373 KVTPIR----TSTTRRTLkslytyfvnVIHVKVINSTNANQPekglkylgnenDFSDLQVYKILELS--RNPMIYRILLD 446

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 302 SLAPSIHGHDYVKKAILCLLLGGVERDLENGSHI---------RGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRG 372
Cdd:PTZ00111  447 SFAPSIKARNNVKIGLLCQLFSGNKNSSDFNKSPdacykvdnfRGIINVLLCGDPGTAKSQLLHYTHLLSPRSIYTSGKS 526

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 373 SSGVGLTAAVT-TDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAA 451
Cdd:PTZ00111  527 SSSVGLTASIKfNESDNGRAMIQPGAVVLANGGVCCIDELDKCHNESRLSLYEVMEQQTVTIAKAGIVATLKAETAILAS 606

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 452 ANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRmhryrapgeqdgdAMPLGSAVDILATDD 531
Cdd:PTZ00111  607 CNPINSRYNKNKAVIENINISPSLFTRFDLIYLVLDHIDQDTDQLISLSIAK-------------DFLLPHMTGSGNDED 673

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 532 PnfsqEDQQDTQIYEkhdnllhgtkkkKQVVRCGREMeftvcgsreKMVSAAFMKKYIHVAKI-IKPVLTQESATYIAEE 610
Cdd:PTZ00111  674 T----YDRSNTMHVE------------DESLRSEKDY---------NKNDLDMLRMYIKFSKLhCFPKLSDEAKKVITRE 728

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 611 YSRLRSQDSMSSDT--------------------ARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYAY 670
Cdd:PTZ00111  729 YVKMRQGNFQTSNLdelehaqedddddlyyqssgTRMIYVSSRMISSIIRISVSLARMRLSTVVTPADALQAVQIVKSST 808


                  .
gi 1484505927 671 F 671
Cdd:PTZ00111  809 F 809
MCM9 cd17760
DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a ...
 299-669 6.99e-70

DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a complex with Mcm8 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350666 [Multi-domain]  Cd Length: 299  Bit Score: 232.44  E-value: 6.99e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 299 LAKSLAPSIHGHDYVKKAILCLLLGGVERDLENGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGVGL 378
Cdd:cd17760     2 ILASLCPQVFGLYNVKLAVAMVLAGGVQRIDASGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTAGIGSTSAGL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 379 TaaVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPvYGR 458
Cdd:cd17760    82 T--VTAVKDGGEWNLEAGALVLADGGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNP-KGQ 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 459 YDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLrmhryrapgEQDGDamplgsavdilatddpnfsqed 538
Cdd:cd17760   159 YDPNESISVNIALASPLLSRFDLVLVLLDTKNEDWDRIISSFIL---------ENKGE---------------------- 207

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 539 qqdtqiyekhdnllhgTKKKkqvvrcgremefTVCGSREKmvsaafMKKYIHVAKIIKPVLTQESATyIAEEYSRLRSQd 618
Cdd:cd17760   208 ----------------PSKS------------SKLWSMEK------MRTYFCLIKNLRPVLSDEANA-ILLRYYQLQRQ- 251

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1484505927 619 smsSDTARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYA 669
Cdd:cd17760   252 ---SDCRNAARTTIRMLESLIRLAEAHARLMFRETVTEEDAITVVSVMESS 299
MCM8 cd17759
DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a ...
 299-669 7.79e-67

DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a complex with Mcm9 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350665 [Multi-domain]  Cd Length: 289  Bit Score: 223.95  E-value: 7.79e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 299 LAKSLAPSIHGHDYVKKAILCLLLGGVER--DLENGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGV 376
Cdd:cd17759     2 IVNSLCPAIYGHELVKAGLLLSLFGGKQKyaDDKNRIPIRGDPHVLIVGDPGLGKSQMLQAACNIAPRGVYVCGNTTTTS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 377 GLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDmDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVY 456
Cdd:cd17759    82 GLTVTLTKDGRSGDFALEAGALVLGDQGICGIDEFDKMGS-QHQALLEAMEQQSVSLAKAGVVCSLPARTSVIAAANPVG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 457 GRYDQYKTPMENIGLQDSLLSRFDLLFIMLDqmDPEQDReisDHVLRMHryrapgeqdgdamplgsavdilatddpnfsq 536
Cdd:cd17759   161 GHYNKGKTVSENLKMGPALLSRFDLVFILLD--TPSEEH---DHLLSEH------------------------------- 204

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 537 edqqdtqiyekhdnllhgtkkkKQVVRcgremeftvcgsreKMVSAAfmKKYIHvakiikPVLTQESATYIAEEYSRLRS 616
Cdd:cd17759   205 ----------------------HQLLR--------------KYISYA--RQYVN------PVLSKDASEALQEFYLELRK 240

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1484505927 617 QdsmsSDTARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYA 669
Cdd:cd17759   241 Q----NQLADSSPITTRQLESLIRLTEARARLELREEATKEDAEDVIEIMKES 289
MCM_OB pfam17207
MCM OB domain; This family contains an OB-fold found within MCM proteins. This domain contains ...
 114-245 3.23e-36

MCM OB domain; This family contains an OB-fold found within MCM proteins. This domain contains an insertion at the zinc binding motif.


Pssm-ID: 465381 [Multi-domain]  Cd Length: 126  Bit Score: 132.61  E-value: 3.23e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 114 RTLTSCFLSCVVCVEGIVTKCSLVRPKVVRSVHYCPATKKTIERRYSDLTTLVAFPSSSVYPtkdeenNPLETEygLSVY 193
Cdd:pfam17207   3 RDLRSEHIGKLVSVSGIVTRTSEVRPKLKKATFTCRKCGHTVGVKITEPTKCPNPECGNKDP------FKLVHE--KSKF 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1484505927 194 KDHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKAKPGDRVQVVGTYRCLP 245
Cdd:pfam17207  75 VDFQKIKIQESPEEVPAGELPRSLDVILDDDLVDRVKPGDRVTVTGIYRVVP 126
MCM_lid pfam17855
MCM AAA-lid domain; This entry represents the AAA-lid domain found in MCM proteins.
 584-667 1.36e-22

MCM AAA-lid domain; This entry represents the AAA-lid domain found in MCM proteins.


Pssm-ID: 465534 [Multi-domain]  Cd Length: 86  Bit Score: 92.22  E-value: 1.36e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 584 FMKKYIHVAKI-IKPVLTQESATYIAEEYSRLRSqdsMSSDTARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEA 662
Cdd:pfam17855   2 LLRKYIAYAREkIKPKLSEEAREKLVDAYVELRK---ESTGSGSSIPITVRQLESLIRLSEAHAKMRLSEIVTEEDVEEA 78


                  ....*
gi 1484505927 663 VELVQ 667
Cdd:pfam17855  79 IRLLK 83
MCM_N pfam14551
MCM N-terminal domain; This family contains the N-terminal domain of MCM proteins.
 16-104 9.90e-17

MCM N-terminal domain; This family contains the N-terminal domain of MCM proteins.


Pssm-ID: 464206 [Multi-domain]  Cd Length: 95  Bit Score: 76.18  E-value: 9.90e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927  16 QRDYLDFLD----DEEDQGIYQSKVRELISDNQYRLIVNVNDLRRKNEKRANRLLNNAFEELVAFQRALKDFVASI--DA 89
Cdd:pfam14551   1 KRKFKDFLEefreDGDGEFKYRDQLREMIEREQRSLEVDLDDLREFDPDLAEALLENPYEYLPLFEEALKEVVKELseDP 80

                          90
                  ....*....|....*
gi 1484505927  90 TYAKQYEEFYVGLEG 104
Cdd:pfam14551  81 DYAEEEKEFQVRFYN 95
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
 297-512 4.22e-07

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 52.48  E-value: 4.22e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 297 DQLAKSLAPSIHGHDYVKKAIL-CLLLGGverdlengshirgdiNILLIGDPSVAKSQLLR---YVLCTAPRAIPTTgrg 372
Cdd:COG0714     4 ARLRAEIGKVYVGQEELIELVLiALLAGG---------------HLLLEGVPGVGKTTLAKalaRALGLPFIRIQFT--- 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 373 ssgVGLTAA-VT----TDQETGERRLEAGAmVLAdrGVVCIDEFDKMSDmdRT--AIHEVMEQGRVTIakAGIHARLNAR 445
Cdd:COG0714    66 ---PDLLPSdILgtyiYDQQTGEFEFRPGP-LFA--NVLLADEINRAPP--KTqsALLEAMEERQVTI--PGGTYKLPEP 135

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 446 CSVLAAANPVygrydqyktpmENIG---LQDSLLSRFdLLFIMLDQMDPEQDREIsdhvLRMHRYRAPGE 512
Cdd:COG0714   136 FLVIATQNPI-----------EQEGtypLPEAQLDRF-LLKLYIGYPDAEEEREI----LRRHTGRHLAE 189
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 340-479 6.26e-05

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 43.44  E-value: 6.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 340 NILLIGDPSVAKSQLLRYV---LCTAPRAIpttgrgssgVGLTAAVTTDQETGERRLEAGAMVLADR---------GVVC 407
Cdd:pfam07728   1 GVLLVGPPGTGKTELAERLaaaLSNRPVFY---------VQLTRDTTEEDLFGRRNIDPGGASWVDGplvraaregEIAV 71

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1484505927 408 IDEFDKMSDMDRTAIHEVMEQGRVTIAKAG--IHARLNARcSVLAAANPVYGRydqyktPMEnigLQDSLLSRF 479
Cdd:pfam07728  72 LDEINRANPDVLNSLLSLLDERRLLLPDGGelVKAAPDGF-RLIATMNPLDRG------LNE---LSPALRSRF 135
Mg_chelatase pfam01078
Magnesium chelatase, subunit ChlI; Magnesium-chelatase is a three-component enzyme that ...
 396-454 1.24e-04

Magnesium chelatase, subunit ChlI; Magnesium-chelatase is a three-component enzyme that catalyzes the insertion of Mg2+ into protoporphyrin IX. This is the first unique step in the synthesis of (bacterio)chlorophyll. Due to this, it is thought that Mg-chelatase has an important role in channelling inter- mediates into the (bacterio)chlorophyll branch in response to conditions suitable for photosynthetic growth. ChlI and BchD have molecular weight between 38-42 kDa.


Pssm-ID: 426032 [Multi-domain]  Cd Length: 207  Bit Score: 44.06  E-value: 1.24e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1484505927 396 GAMVLADRGVVCIDEfdkMSDMDRTAI---HEVMEQGRVTIAKAGIHARLNARCSVLAAANP 454
Cdd:pfam01078 100 GEISLAHNGVLFLDE---LPEFKRRVLeslRQPLEDGEITISRARAKVTFPARFQLVAAMNP 158
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 340-485 5.02e-04

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 41.36  E-value: 5.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505927 340 NILLIGDPSVAKSQLLRYVLCTAPRaipttgRGSSGVGLTAAVTT-------DQETGERRLEAGAMVLADRGVVCIDEFD 412
Cdd:cd00009    21 NLLLYGPPGTGKTTLARAIANELFR------PGAPFLYLNASDLLeglvvaeLFGHFLVRLLFELAEKAKPGVLFIDEID 94

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1484505927 413 KMSDMDRTAIHEVMEQGRVTIAKagiharlNARCSVLAAANpvygrydqyktPMENIGLQDSLLSRFDLLFIM 485
Cdd:cd00009    95 SLSRGAQNALLRVLETLNDLRID-------RENVRVIGATN-----------RPLLGDLDRALYDRLDIRIVI 149
YifB COG0606
Predicted Mg-chelatase, contains ChlI-like and ATPase domains, YifB family [Posttranslational ...
 396-454 1.44e-03

Predicted Mg-chelatase, contains ChlI-like and ATPase domains, YifB family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440371 [Multi-domain]  Cd Length: 502  Bit Score: 41.95  E-value: 1.44e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1484505927 396 GAMVLADRGVVCIDEfdkMSDMDRTAIhEV----MEQGRVTIAKAGIHARLNARCSVLAAANP 454
Cdd:COG0606   290 GEISLAHNGVLFLDE---LPEFSRRVL-EAlrqpLEDGEVTISRANGSVTYPARFQLVAAMNP 348
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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