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Conserved domains on  [gi|1489866114|ref|NP_001353546|]
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regulator of G-protein signaling 14 isoform 2 [Homo sapiens]

Protein Classification

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List of domain hits

Name Accession Description Interval E-value
RGS_RGS14 cd08743
Regulator of G protein signaling (RGS) domain found in the RGS14 protein; RGS (Regulator of ...
58-186 5.11e-94

Regulator of G protein signaling (RGS) domain found in the RGS14 protein; RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS14 protein. RGS14 is a member of the RA/RGS subfamily of RGS proteins family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS14 belong to the R12 RGS subfamily, which includes RGS10 and RGS12, all of which are highly selective for G-alpha-i1 over G-alpha-q. RGS14 binds and regulates the subcellular localization and activities of H-Ras and Raf kinases in cells and thereby integrates G protein and Ras/Raf signaling pathways.


:

Pssm-ID: 188697  Cd Length: 129  Bit Score: 283.07  E-value: 5.11e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1489866114  58 EQPVASWALSFERLLQDPLGLAYFTEFLKKEFSAENVTFWKACERFQQIPASDTQQLAQEARNIYQEFLSSQALSPVNID 137
Cdd:cd08743     1 EKSVASWAVSFERLLQDPLGVEYFTEFLKKEFSAENVNFWKACERFQQIPASDTQQLAQEARKIYNEFLSSSSQSPVNID 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1489866114 138 RQAWLGEEVLAEPRPDMFRAQQLQIFNLMKFDSYARFVKSPLYRECLLA 186
Cdd:cd08743    81 QQAWIGEDMLATPSPDMFRAQQLQIFNLMKFDSYARFVKSPLYQDCLLA 129
RBD1_RGS14 cd17137
Ras-binding domain (RBD) 1 of regulator of G protein signaling 14 (RGS14); RGS12 (regulator of ...
302-372 2.87e-43

Ras-binding domain (RBD) 1 of regulator of G protein signaling 14 (RGS14); RGS12 (regulator of G protein signaling 14) is a RGS protein with a multidomain structure that allows it to interact with binding partners from multiple signaling pathways. RGS proteins belong to a large family of GTPase-accelerating proteins (GAPs) which act as key inhibitors of G-protein-mediated cell responses in eukaryotes. RGS14 contains an N-terminal RGS domain, two tandem Ras-binding domains (RBDs) and a G protein regulatory (GPR, also referred to as a GoLoco) motif. RGS14 binds activated H-Ras-GTP through its first RBD and interacts with Rap2-GTP and RAF kinases by the second tandem RBD. RBD is structurally similar to the beta-grasp fold of ubiquitin, a common structure involved in protein-protein interactions. RGS14 modulates neuronal physiology and all of its binding partners have roles in synaptic plasticity.


:

Pssm-ID: 340657  Cd Length: 71  Bit Score: 148.42  E-value: 2.87e-43
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1489866114 302 KYCCVYLPDGTASLALARPGLTIRDMLAGICEKRGLSLPDIKVYLVGNEQKALVLDQDCTVLADQEVRLEN 372
Cdd:cd17137     1 KYCCVYLPDGTASLASVRPGLTIRDMLSGICEKRGISLPDVKVYLVGNEKKPLVLDQDCSVLTDQEVRLEN 71
RBD2_RGS14 cd17139
Ras-binding domain (RBD) 2 of regulator of G protein signaling 14 (RGS14); RGS14 (regulator of ...
373-444 1.63e-29

Ras-binding domain (RBD) 2 of regulator of G protein signaling 14 (RGS14); RGS14 (regulator of G protein signaling 14) is a RGS protein with a multidomain structure that allows it to interact with binding partners from multiple signaling pathways. RGS proteins belong to a large family of GTPase-accelerating proteins (GAPs) which act as key inhibitors of G-protein-mediated cell responses in eukaryotes. RGS14 contains an N-terminal RGS domain, two tandem Ras-binding domains (RBDs) and a G protein regulatory (GPR, also referred to as a GoLoco) motif. RGS14 binds activated H-Ras-GTP through its first RBD and interacts with RAP2-GTP and RAF kinases by the second tandem RBD. RBD is structurally similar to the beta-grasp fold of ubiquitin, a common structure involved in protein-protein interactions. RGS14 modulates neuronal physiology and all of its binding partners have roles in synaptic plasticity.


:

Pssm-ID: 340659  Cd Length: 73  Bit Score: 110.84  E-value: 1.63e-29
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1489866114 373 RITFELELTALERVVRISAKPTKRLQEALQPILEKHGLSPLEVVLHRPGEKQPLDLGKLVSSVAAQRLVLDT 444
Cdd:cd17139     1 RITFELEIAFLGKTVRIVAKSSKTLQEALQPILQKYGLRPQEVVLTMSGEKQALDMNTPVSSLANKTLVLDR 72
GoLoco pfam02188
GoLoco motif;
500-521 1.28e-03

GoLoco motif;


:

Pssm-ID: 460481  Cd Length: 22  Bit Score: 36.24  E-value: 1.28e-03
                          10        20
                  ....*....|....*....|..
gi 1489866114 500 EGLVELLNRVQSSGAHDQRGLL 521
Cdd:pfam02188   1 EDFFDLLARVQSSRLDDQRCSL 22
 
Name Accession Description Interval E-value
RGS_RGS14 cd08743
Regulator of G protein signaling (RGS) domain found in the RGS14 protein; RGS (Regulator of ...
58-186 5.11e-94

Regulator of G protein signaling (RGS) domain found in the RGS14 protein; RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS14 protein. RGS14 is a member of the RA/RGS subfamily of RGS proteins family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS14 belong to the R12 RGS subfamily, which includes RGS10 and RGS12, all of which are highly selective for G-alpha-i1 over G-alpha-q. RGS14 binds and regulates the subcellular localization and activities of H-Ras and Raf kinases in cells and thereby integrates G protein and Ras/Raf signaling pathways.


Pssm-ID: 188697  Cd Length: 129  Bit Score: 283.07  E-value: 5.11e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1489866114  58 EQPVASWALSFERLLQDPLGLAYFTEFLKKEFSAENVTFWKACERFQQIPASDTQQLAQEARNIYQEFLSSQALSPVNID 137
Cdd:cd08743     1 EKSVASWAVSFERLLQDPLGVEYFTEFLKKEFSAENVNFWKACERFQQIPASDTQQLAQEARKIYNEFLSSSSQSPVNID 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1489866114 138 RQAWLGEEVLAEPRPDMFRAQQLQIFNLMKFDSYARFVKSPLYRECLLA 186
Cdd:cd08743    81 QQAWIGEDMLATPSPDMFRAQQLQIFNLMKFDSYARFVKSPLYQDCLLA 129
RBD1_RGS14 cd17137
Ras-binding domain (RBD) 1 of regulator of G protein signaling 14 (RGS14); RGS12 (regulator of ...
302-372 2.87e-43

Ras-binding domain (RBD) 1 of regulator of G protein signaling 14 (RGS14); RGS12 (regulator of G protein signaling 14) is a RGS protein with a multidomain structure that allows it to interact with binding partners from multiple signaling pathways. RGS proteins belong to a large family of GTPase-accelerating proteins (GAPs) which act as key inhibitors of G-protein-mediated cell responses in eukaryotes. RGS14 contains an N-terminal RGS domain, two tandem Ras-binding domains (RBDs) and a G protein regulatory (GPR, also referred to as a GoLoco) motif. RGS14 binds activated H-Ras-GTP through its first RBD and interacts with Rap2-GTP and RAF kinases by the second tandem RBD. RBD is structurally similar to the beta-grasp fold of ubiquitin, a common structure involved in protein-protein interactions. RGS14 modulates neuronal physiology and all of its binding partners have roles in synaptic plasticity.


Pssm-ID: 340657  Cd Length: 71  Bit Score: 148.42  E-value: 2.87e-43
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1489866114 302 KYCCVYLPDGTASLALARPGLTIRDMLAGICEKRGLSLPDIKVYLVGNEQKALVLDQDCTVLADQEVRLEN 372
Cdd:cd17137     1 KYCCVYLPDGTASLASVRPGLTIRDMLSGICEKRGISLPDVKVYLVGNEKKPLVLDQDCSVLTDQEVRLEN 71
RGS smart00315
Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins ...
67-183 3.35e-39

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 214613  Cd Length: 118  Bit Score: 139.33  E-value: 3.35e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1489866114   67 SFERLLQDPLGLAYFTEFLKKEFSAENVTFWKACERFQQIPasDTQQLAQEARNIYQEFLSSQALSPVNIDRQAWlgEEV 146
Cdd:smart00315   1 SLESLLSDPIGRLLFREFLESEFSEENLEFWLAVEEFKKAE--DDEERIAKAREIYDKFLSPNAPKEVNLDSDLR--EKI 76
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1489866114  147 L-----AEPRPDMFRAQQLQIFNLMKFDSYARFVKSPLYREC 183
Cdd:smart00315  77 EenlesEEPPPDLFDEAQREVYELLEKDSFPRFLESDYYLRF 118
RGS pfam00615
Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for ...
67-183 1.69e-36

Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 459870  Cd Length: 117  Bit Score: 131.58  E-value: 1.69e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1489866114  67 SFERLLQDPLGLAYFTEFLKKEFSAENVTFWKACERFQQIPASDtqQLAQEARNIYQEFLSSQALSPVNIDRQAW--LGE 144
Cdd:pfam00615   1 SFDSLLEDQPGRRLFRQFLESEFSEENLEFWLACEEFKKADPDE--ERLKKAKEIYNEFLAPGSPKEINLDSDLReeIRE 78
                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1489866114 145 EVLAEPRPDMFRAQQLQIFNLMKFDSYARFVKSPLYREC 183
Cdd:pfam00615  79 NLEKEPTRDLFDEAQAEVYELMEKDSYPRFLKSPLYLRL 117
RBD2_RGS14 cd17139
Ras-binding domain (RBD) 2 of regulator of G protein signaling 14 (RGS14); RGS14 (regulator of ...
373-444 1.63e-29

Ras-binding domain (RBD) 2 of regulator of G protein signaling 14 (RGS14); RGS14 (regulator of G protein signaling 14) is a RGS protein with a multidomain structure that allows it to interact with binding partners from multiple signaling pathways. RGS proteins belong to a large family of GTPase-accelerating proteins (GAPs) which act as key inhibitors of G-protein-mediated cell responses in eukaryotes. RGS14 contains an N-terminal RGS domain, two tandem Ras-binding domains (RBDs) and a G protein regulatory (GPR, also referred to as a GoLoco) motif. RGS14 binds activated H-Ras-GTP through its first RBD and interacts with RAP2-GTP and RAF kinases by the second tandem RBD. RBD is structurally similar to the beta-grasp fold of ubiquitin, a common structure involved in protein-protein interactions. RGS14 modulates neuronal physiology and all of its binding partners have roles in synaptic plasticity.


Pssm-ID: 340659  Cd Length: 73  Bit Score: 110.84  E-value: 1.63e-29
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1489866114 373 RITFELELTALERVVRISAKPTKRLQEALQPILEKHGLSPLEVVLHRPGEKQPLDLGKLVSSVAAQRLVLDT 444
Cdd:cd17139     1 RITFELEIAFLGKTVRIVAKSSKTLQEALQPILQKYGLRPQEVVLTMSGEKQALDMNTPVSSLANKTLVLDR 72
RBD pfam02196
Raf-like Ras-binding domain;
303-371 1.42e-27

Raf-like Ras-binding domain;


Pssm-ID: 460485  Cd Length: 69  Bit Score: 105.29  E-value: 1.42e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1489866114 303 YCCVYLPDGTASLALARPGLTIRDMLAGICEKRGLSLPDIKVYLVGNEQKALVLDQDCTVLADQEVRLE 371
Cdd:pfam02196   1 LCRVYLPDGQRTVVQVRPGETVRDALSKLCKKRGLNPEACDVYLVGGDKYPLDLDTDSSTLEGEEVRVE 69
RBD smart00455
Raf-like Ras-binding domain;
303-373 2.15e-20

Raf-like Ras-binding domain;


Pssm-ID: 128731  Cd Length: 70  Bit Score: 85.03  E-value: 2.15e-20
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1489866114  303 YCCVYLPDGTASLALARPGLTIRDMLAGICEKRGLSLPDIKVYLVGnEQKALVLDQDCTVLADQEVRLENR 373
Cdd:smart00455   1 TCKVHLPDNQRTVVKVRPGKTVRDALAKALKKRGLNPECCVVRLRG-EKKPLDLNQPISSLDGQELVVEEL 70
RBD smart00455
Raf-like Ras-binding domain;
376-445 5.54e-19

Raf-like Ras-binding domain;


Pssm-ID: 128731  Cd Length: 70  Bit Score: 81.18  E-value: 5.54e-19
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1489866114  376 FELELTALERVVRISAKPTKRLQEALQPILEKHGLSPLEVVLHRPGEKQPLDLGKLVSSVAAQRLVLDTL 445
Cdd:smart00455   1 TCKVHLPDNQRTVVKVRPGKTVRDALAKALKKRGLNPECCVVRLRGEKKPLDLNQPISSLDGQELVVEEL 70
GoLoco pfam02188
GoLoco motif;
500-521 1.28e-03

GoLoco motif;


Pssm-ID: 460481  Cd Length: 22  Bit Score: 36.24  E-value: 1.28e-03
                          10        20
                  ....*....|....*....|..
gi 1489866114 500 EGLVELLNRVQSSGAHDQRGLL 521
Cdd:pfam02188   1 EDFFDLLARVQSSRLDDQRCSL 22
GoLoco smart00390
LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins
499-521 1.54e-03

LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins


Pssm-ID: 214645  Cd Length: 23  Bit Score: 35.94  E-value: 1.54e-03
                           10        20
                   ....*....|....*....|...
gi 1489866114  499 IEGLVELLNRVQSSGAHDQRGLL 521
Cdd:smart00390   1 DEDLFDLLLRMQSSRMDDQRCEL 23
 
Name Accession Description Interval E-value
RGS_RGS14 cd08743
Regulator of G protein signaling (RGS) domain found in the RGS14 protein; RGS (Regulator of ...
58-186 5.11e-94

Regulator of G protein signaling (RGS) domain found in the RGS14 protein; RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS14 protein. RGS14 is a member of the RA/RGS subfamily of RGS proteins family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS14 belong to the R12 RGS subfamily, which includes RGS10 and RGS12, all of which are highly selective for G-alpha-i1 over G-alpha-q. RGS14 binds and regulates the subcellular localization and activities of H-Ras and Raf kinases in cells and thereby integrates G protein and Ras/Raf signaling pathways.


Pssm-ID: 188697  Cd Length: 129  Bit Score: 283.07  E-value: 5.11e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1489866114  58 EQPVASWALSFERLLQDPLGLAYFTEFLKKEFSAENVTFWKACERFQQIPASDTQQLAQEARNIYQEFLSSQALSPVNID 137
Cdd:cd08743     1 EKSVASWAVSFERLLQDPLGVEYFTEFLKKEFSAENVNFWKACERFQQIPASDTQQLAQEARKIYNEFLSSSSQSPVNID 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1489866114 138 RQAWLGEEVLAEPRPDMFRAQQLQIFNLMKFDSYARFVKSPLYRECLLA 186
Cdd:cd08743    81 QQAWIGEDMLATPSPDMFRAQQLQIFNLMKFDSYARFVKSPLYQDCLLA 129
RGS_R12-like cd08706
Regulator of G protein signaling (RGS) domain found in the R12 subfamily of proteins; The RGS ...
68-182 1.28e-74

Regulator of G protein signaling (RGS) domain found in the R12 subfamily of proteins; The RGS (Regulator of G-protein Signaling) domain is an essential part of the R12 (Neuronal RGS) protein subfamily of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play a critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of G-protein signaling, controlled by RGS domain, accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP that results in reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The R12 RGS subfamily includes RGS10, RGS12 and RGS14 all of which are highly selective for G-alpha-i1 over G-alpha-q.


Pssm-ID: 188661  Cd Length: 113  Bit Score: 232.60  E-value: 1.28e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1489866114  68 FERLLQDPLGLAYFTEFLKKEFSAENVTFWKACERFQQIPasDTQQLAQEARNIYQEFLSSQALSPVNIDRQAWLGEEVL 147
Cdd:cd08706     1 FERLLQDPVGVKYFTEFLKKEFSEENILFWQACEKFKKIP--DKKQLVQEAREIYDTFLSSKASSPVNIDSQAQLAEEML 78
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1489866114 148 AEPRPDMFRAQQLQIFNLMKFDSYARFVKSPLYRE 182
Cdd:cd08706    79 EEPHPDMFQKQQLQIFNLMKFDSYSRFLKSPLYQQ 113
RGS_RGS12 cd08742
Regulator of G protein signaling (RGS) domain found in the RGS12 protein; RGS (Regulator of ...
68-182 2.58e-55

Regulator of G protein signaling (RGS) domain found in the RGS12 protein; RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS12 protein. RGS12 is a member of the RA/RGS subfamily of RGS proteins family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS12 belong to the R12 RGS subfamily, which includes RGS10 and RGS14, all of which are highly selective for G-alpha-i1 over G-alpha-q. RGS12 exist in multiple splice variants: RGS12s (short) contains the core RGS/RBD/GoLoco domains, while RGS12L (long) has additional N-terminal PDZ and PTB domains. RGS12 splice variants show distinct expression patterns, suggesting that they have discrete functions during mouse embryogenesis. RGS12 also may play a critical role in coordinating Ras-dependent signals that are required for promoting and maintaining neuronal differentiation.


Pssm-ID: 188696  Cd Length: 115  Bit Score: 182.18  E-value: 2.58e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1489866114  68 FERLLQDPLGLAYFTEFLKKEFSAENVTFWKACERFQQIPASDTQQLAQEARNIYQEFLSSQALSPVNIDRQAWLGEEVL 147
Cdd:cd08742     1 FERLLQDPVGVRYFSEFLRKEFSEENILFWQACEYFNHVPAHDKKELSYRAREIFSKFLCSKATTPVNIDSQAQLADDIL 80
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1489866114 148 AEPRPDMFRAQQLQIFNLMKFDSYARFVKSPLYRE 182
Cdd:cd08742    81 NAPHPDMFKEQQLQIFNLMKFDSYTRFLKSPLYQE 115
RBD1_RGS14 cd17137
Ras-binding domain (RBD) 1 of regulator of G protein signaling 14 (RGS14); RGS12 (regulator of ...
302-372 2.87e-43

Ras-binding domain (RBD) 1 of regulator of G protein signaling 14 (RGS14); RGS12 (regulator of G protein signaling 14) is a RGS protein with a multidomain structure that allows it to interact with binding partners from multiple signaling pathways. RGS proteins belong to a large family of GTPase-accelerating proteins (GAPs) which act as key inhibitors of G-protein-mediated cell responses in eukaryotes. RGS14 contains an N-terminal RGS domain, two tandem Ras-binding domains (RBDs) and a G protein regulatory (GPR, also referred to as a GoLoco) motif. RGS14 binds activated H-Ras-GTP through its first RBD and interacts with Rap2-GTP and RAF kinases by the second tandem RBD. RBD is structurally similar to the beta-grasp fold of ubiquitin, a common structure involved in protein-protein interactions. RGS14 modulates neuronal physiology and all of its binding partners have roles in synaptic plasticity.


Pssm-ID: 340657  Cd Length: 71  Bit Score: 148.42  E-value: 2.87e-43
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1489866114 302 KYCCVYLPDGTASLALARPGLTIRDMLAGICEKRGLSLPDIKVYLVGNEQKALVLDQDCTVLADQEVRLEN 372
Cdd:cd17137     1 KYCCVYLPDGTASLASVRPGLTIRDMLSGICEKRGISLPDVKVYLVGNEKKPLVLDQDCSVLTDQEVRLEN 71
RGS_RGS10 cd08741
Regulator of G protein signaling (RGS) domain found in the RGS10 protein; RGS (Regulator of ...
68-180 2.78e-39

Regulator of G protein signaling (RGS) domain found in the RGS10 protein; RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS10 protein. RGS10 is a member of the RA/RGS subfamily of RGS proteins family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS10 belong to the R12 RGS subfamily, which includes RGS12 and RGS14, all of which are highly selective for G-alpha-i1 over G-alpha-q. RGS10 exists in 2 splice isoforms. RGS10A is specifically expressed in osteoclasts and is a key component in the RANKL signaling mechanism for osteoclast differentiation, whereas RGS10B expressed in brain and in immune tissues and has been implicated in diverse processes including: promoting of dopaminergic neuron survival via regulation of the microglial inflammatory response, modulation of presynaptic and postsynaptic G-protein signalling, as well as a possible role in regulation of gene expression.


Pssm-ID: 188695  Cd Length: 113  Bit Score: 139.41  E-value: 2.78e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1489866114  68 FERLLQDPLGLAYFTEFLKKEFSAENVTFWKACERFQQipASDTQQLAQEARNIYQEFLSSQALSPVNIDRQAWLGEEVL 147
Cdd:cd08741     1 LENLLEDPEGVKRFREFLKKEFSEENVLFWLACEDFKK--MQDKTQMQEKAKEIYMTFLSSKASSQVNVEGQSRLNEKIL 78
                          90       100       110
                  ....*....|....*....|....*....|...
gi 1489866114 148 AEPRPDMFRAQQLQIFNLMKFDSYARFVKSPLY 180
Cdd:cd08741    79 EEPHPLMFQKLQDQIFNLMKYDSYSRFLKSDLF 111
RGS smart00315
Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins ...
67-183 3.35e-39

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 214613  Cd Length: 118  Bit Score: 139.33  E-value: 3.35e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1489866114   67 SFERLLQDPLGLAYFTEFLKKEFSAENVTFWKACERFQQIPasDTQQLAQEARNIYQEFLSSQALSPVNIDRQAWlgEEV 146
Cdd:smart00315   1 SLESLLSDPIGRLLFREFLESEFSEENLEFWLAVEEFKKAE--DDEERIAKAREIYDKFLSPNAPKEVNLDSDLR--EKI 76
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1489866114  147 L-----AEPRPDMFRAQQLQIFNLMKFDSYARFVKSPLYREC 183
Cdd:smart00315  77 EenlesEEPPPDLFDEAQREVYELLEKDSFPRFLESDYYLRF 118
RGS_R7-like cd08705
Regulator of G protein signaling (RGS) domain found in the R7 subfamily of proteins; The RGS ...
61-182 8.16e-39

Regulator of G protein signaling (RGS) domain found in the R7 subfamily of proteins; The RGS (Regulator of G-protein Signaling) domain is an essential part of the R7 (Neuronal RGS) protein subfamily of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The R7 subfamily includes RGS6, RGS7, RGS9, and RGS11, all of which, in humans, are expressed predominantly in the nervous system, form an obligatory complex with G-beta-5, and play important roles in the regulation of crucial neuronal processes. In addition, R7 proteins were found to bind many other proteins outside of the G protein signaling pathways including: m-opioid receptor, beta-arrestin, alpha-actinin-2, NMDAR, polycystin, spinophilin, guanylyl cyclase, among others.


Pssm-ID: 188660  Cd Length: 121  Bit Score: 138.14  E-value: 8.16e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1489866114  61 VASWALSFERLLQDPLGLAYFTEFLKKEFSAENVTFWKACERFQQIPASDTQQLAQEarnIYQEFLSSQALSPVNID-RQ 139
Cdd:cd08705     2 VKRWGFSFSELLKDPVGREQFLKFLEKEFSGENLRFWEACQDLKYGPQSQVPEKVQE---IYQEFLAPGAPSWINIDsKT 78
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1489866114 140 AWLGEEVLAEPRPDMFRAQQLQIFNLMKFDSYARFVKSPLYRE 182
Cdd:cd08705    79 MEITLKNLKDPHRYTFDAAQEHIYMLMKKDSYPRFLRSDIYKE 121
RGS pfam00615
Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for ...
67-183 1.69e-36

Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 459870  Cd Length: 117  Bit Score: 131.58  E-value: 1.69e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1489866114  67 SFERLLQDPLGLAYFTEFLKKEFSAENVTFWKACERFQQIPASDtqQLAQEARNIYQEFLSSQALSPVNIDRQAW--LGE 144
Cdd:pfam00615   1 SFDSLLEDQPGRRLFRQFLESEFSEENLEFWLACEEFKKADPDE--ERLKKAKEIYNEFLAPGSPKEINLDSDLReeIRE 78
                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1489866114 145 EVLAEPRPDMFRAQQLQIFNLMKFDSYARFVKSPLYREC 183
Cdd:pfam00615  79 NLEKEPTRDLFDEAQAEVYELMEKDSYPRFLKSPLYLRL 117
RGS cd07440
Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part ...
72-182 9.49e-31

Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. While inactive, G-alpha-subunits bind GDP, which is released and replaced by GTP upon agonist activation. GTP binding leads to dissociation of the alpha-subunit and the beta-gamma-dimer, allowing them to interact with effectors molecules and propagate signaling cascades associated with cellular growth, survival, migration, and invasion. Deactivation of the G-protein signaling controlled by the RGS domain accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in the reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins are also involved in apoptosis and cell proliferation, as well as modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play important roles in neuronal signals modulation. Some RGS proteins are principal elements needed for proper vision.


Pssm-ID: 188659 [Multi-domain]  Cd Length: 113  Bit Score: 115.95  E-value: 9.49e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1489866114  72 LQDPLGLAYFTEFLKKEFSAENVTFWKACERFQQIPASDTqQLAQEARNIYQEFLSSQALSPVNIDRQ-------AWLGE 144
Cdd:cd07440     1 LRDPYGLEYFRQFLKSEHCEENLEFWLAVEKFKKTTSSDE-ELKSKAKEIYDKYISKDAPKEINIPESireeieeNLEEP 79
                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1489866114 145 evlaEPRPDMFRAQQLQIFNLMKFDSYARFVKSPLYRE 182
Cdd:cd07440    80 ----YPDPDCFDEAQEHILNLLEKDSYPRFLKSDLYLK 113
RBD2_RGS14 cd17139
Ras-binding domain (RBD) 2 of regulator of G protein signaling 14 (RGS14); RGS14 (regulator of ...
373-444 1.63e-29

Ras-binding domain (RBD) 2 of regulator of G protein signaling 14 (RGS14); RGS14 (regulator of G protein signaling 14) is a RGS protein with a multidomain structure that allows it to interact with binding partners from multiple signaling pathways. RGS proteins belong to a large family of GTPase-accelerating proteins (GAPs) which act as key inhibitors of G-protein-mediated cell responses in eukaryotes. RGS14 contains an N-terminal RGS domain, two tandem Ras-binding domains (RBDs) and a G protein regulatory (GPR, also referred to as a GoLoco) motif. RGS14 binds activated H-Ras-GTP through its first RBD and interacts with RAP2-GTP and RAF kinases by the second tandem RBD. RBD is structurally similar to the beta-grasp fold of ubiquitin, a common structure involved in protein-protein interactions. RGS14 modulates neuronal physiology and all of its binding partners have roles in synaptic plasticity.


Pssm-ID: 340659  Cd Length: 73  Bit Score: 110.84  E-value: 1.63e-29
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1489866114 373 RITFELELTALERVVRISAKPTKRLQEALQPILEKHGLSPLEVVLHRPGEKQPLDLGKLVSSVAAQRLVLDT 444
Cdd:cd17139     1 RITFELEIAFLGKTVRIVAKSSKTLQEALQPILQKYGLRPQEVVLTMSGEKQALDMNTPVSSLANKTLVLDR 72
RGS_RGS20 cd08746
Regulator of G protein signaling (RGS) domain found in the RGS20 protein; The RGS (Regulator ...
44-182 2.43e-29

Regulator of G protein signaling (RGS) domain found in the RGS20 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS20 protein (also known as RGSZ1), a member of the RZ subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of G-protein signaling is controlled by the RGS domain, which accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP resulting in reassociation of the alpha-subunit with the beta-gamma-dimer and inhibition of downstream activity. As a major G-protein regulator, the RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The RZ subfamily of RGS proteins include RGS17, RGS19 (former GAIP), and the splice variant of RGS20, Ret-RGS. RGS20 is expressed exclusively in brain, with the highest concentrations in the temporal lobe and the caudate nucleus and may play a role in signaling regulation in these brain regions. RGS20 acts as a GAP of both G-alpha-z and G-alpha-I and controls signaling in the mu opioid receptor pathway.


Pssm-ID: 188700 [Multi-domain]  Cd Length: 167  Bit Score: 113.93  E-value: 2.43e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1489866114  44 HSLPSGPSSPFPTEEQpVASWALSFERLLQDPLGLAYFTEFLKKEFSAENVTFWKACERFQQipASDTQQLAQEARNIYQ 123
Cdd:cd08746    31 EGIPNCEESPKPTLEE-VCAWGQSFDKLMLTPAGRNAFREFLRTEFSEENMLFWMACEELKK--EANKSVIEEKARIIYE 107
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1489866114 124 EFLSsqALSPVNIDRQAWLGEEV---LAEPRPDMFRAQQLQIFNLMKFDSYARFVKSPLYRE 182
Cdd:cd08746   108 DYIS--ILSPKEVSLDSRVREVInrnMLEPSQHTFDDAQLQIYTLMHRDSYPRFMNSAIYKN 167
RBD pfam02196
Raf-like Ras-binding domain;
303-371 1.42e-27

Raf-like Ras-binding domain;


Pssm-ID: 460485  Cd Length: 69  Bit Score: 105.29  E-value: 1.42e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1489866114 303 YCCVYLPDGTASLALARPGLTIRDMLAGICEKRGLSLPDIKVYLVGNEQKALVLDQDCTVLADQEVRLE 371
Cdd:pfam02196   1 LCRVYLPDGQRTVVQVRPGETVRDALSKLCKKRGLNPEACDVYLVGGDKYPLDLDTDSSTLEGEEVRVE 69
RGS_RGS9 cd08739
Regulator of G protein signaling (RGS) domain found in the RGS9 protein; The RGS (Regulator of ...
61-182 5.37e-27

Regulator of G protein signaling (RGS) domain found in the RGS9 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS9 protein, a member of R7 subfamily of the RGS protein family. RGS is a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. Other members of the R7 subfamily (Neuronal RGS) include: RGS6, RGS7, and RGS11, all of which are expressed predominantly in the nervous system, form an obligatory complex with G-beta-5, and play important roles in the regulation of crucial neuronal processes such as vision and motor control. Additionally they have been implicated in many neurological conditions such as anxiety, schizophrenia, and drug dependence. RGS9 forms constitutive complexes with G-beta-5 subunit and controls such fundamental functions as vision and behavior. RGS9 exists in two splice isoforms: RGS9-1 which regulates phototransduction in rods and cones and RGS9-2 which regulates dopamine and opioid signaling in the basal ganglia. In addition, RGS9 was found to bind many other proteins outside of G protein signaling pathways including: mu-opioid receptor, beta-arrestin, alpha-actinin-2, NMDAR, polycystin, spinophilin, and guanylyl cyclase, among others.


Pssm-ID: 188693  Cd Length: 121  Bit Score: 105.49  E-value: 5.37e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1489866114  61 VASWALSFERLLQDPLGLAYFTEFLKKEFSAENVTFWKACERFQQipaSDTQQLAQEARNIYQEFLSSQALSPVNIDRQA 140
Cdd:cd08739     2 VERWAFNFSELIRDPKGRQSFQLFLKKEFSGENLGFWEACEDLKY---GDQSKVKEKAEEIYKLFLAPGARRWINIDGKT 78
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1489866114 141 wLGEEV--LAEPRPDMFRAQQLQIFNLMKFDSYARFVKSPLYRE 182
Cdd:cd08739    79 -MDITVkgLKHPHRYVLDAAQTHIYMLMKKDSYARYLKSPIYKE 121
RGS_RGS11 cd08740
Regulator of G protein signaling (RGS) domain found in the RGS11 protein; The RGS (Regulator ...
61-187 6.33e-27

Regulator of G protein signaling (RGS) domain found in the RGS11 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS11 protein, a member of R7 subfamily of the RGS protein family. RGS is a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. Other members of the R7 subfamily (Neuronal RGS) include: RGS6, RGS7, and RGS9, all of which are expressed predominantly in the nervous system, form an obligatory complex with G-beta-5, and play important roles in the regulation of crucial neuronal processes such as vision and motor control. Additionally they have been implicated in many neurological conditions such as anxiety, schizophrenia, and drug dependence. RGS11 is expressed exclusively in retinal ON-bipolar neurons in which it forms complexes with G-beta-5 and R7AP (RGS7 anchor protein ) and plays crucial roles in processing the light responses of retinal neurons.


Pssm-ID: 188694  Cd Length: 126  Bit Score: 105.76  E-value: 6.33e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1489866114  61 VASWALSFERLLQDPLGLAYFTEFLKKEFSAENVTFWKACERFQQipaSDTQQLAQEARNIYQEFLSSQALSPVNIDRQA 140
Cdd:cd08740     3 VERWGFSFRELLNDPVGRKEFLDFLEKEFSAENLSFWEACEELRY---GEQSKIPELVDSVYQQFLAPGATRWVNIDSKT 79
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1489866114 141 WLGE-EVLAEPRPDMFRAQQLQIFNLMKFDSYARFVKSPLYREcLLAE 187
Cdd:cd08740    80 MERTlEGLKQPHRYVLDDAQMHIYMLMKKDSYPRFLKSDLYKN-LLAE 126
RGS_RGS5 cd08717
Regulator of G protein signaling (RGS) domain found in the RGS5 protein; The RGS (Regulator of ...
68-182 2.19e-26

Regulator of G protein signaling (RGS) domain found in the RGS5 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS5 protein. RGS5 is member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. Two splice isoforms of RGS5 has been found: RGS5L (long) which is expressed in smooth muscle cells (pericytes) and heart and RGS5S (short) which is highly expressed in the ciliary body of the eye, kidney, brain, spleen, skeletal muscle, and small intestine. Outside of the GPCR pathway, RGS5 interacts with the 14-3-3 protein.


Pssm-ID: 188672  Cd Length: 114  Bit Score: 103.53  E-value: 2.19e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1489866114  68 FERLLQDPLGLAYFTEFLKKEFSAENVTFWKACERFQQIpaSDTQQLAQEARNIYQEFLSSQALSPVNIDRqawLGEEV- 146
Cdd:cd08717     1 LDKLLQNSYGLASFKSFLKSEFSEENIEFWEACEDYKKT--KSPLKMATKAKKIYEEFIQTEAPKEVNIDH---FTKDVt 75
                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1489866114 147 ---LAEPRPDMFRAQQLQIFNLMKFDSYARFVKSPLYRE 182
Cdd:cd08717    76 mknLVEPSSSSFDLAQKRIFALMEKDSLPRFVRSEFYQE 114
RBD1_RGS12_like cd01817
Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12) and similar proteins; ...
302-372 1.07e-25

Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12) and similar proteins; Regulator of G protein signaling (RGS) proteins belong to a large family of GTpase-accelerating proteins (GAPs) which act as key inhibitors of G-protein-mediated cell responses in eukaryotes. This RGS12-like subfamily is composed of RGS12 and RGS14, with multidomain architectures including a RGS domain, two tandem Ras-binding domains (RBDs), and a second Galpha interacting domain, the GoLoco motif. The RBD is structurally similar to the beta-grasp fold of ubiquitin, a common structure involved in protein-protein interactions. Ubiquitin is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair.


Pssm-ID: 340515  Cd Length: 70  Bit Score: 99.93  E-value: 1.07e-25
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1489866114 302 KYCCVYLPDGTASLALARPGLTIRDMLAGICEKRGLSLPDIKVYLVGNEqKALVLDQDCTVLADQEVRLEN 372
Cdd:cd01817     1 KLCRVILPDGSTTVVQAKPGETIRQLLTRLLEKRGLSYAAFDVFIVGSD-KPLDLNEDSSILGGKEVRVEQ 70
RGS_RZ-like cd08718
Regulator of G protein signaling (RGS) domain found in the RZ protein; The RGS (Regulator of ...
64-181 3.03e-25

Regulator of G protein signaling (RGS) domain found in the RZ protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RZ subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of G-protein signaling is controlled by RGS domains, which accelerate GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in reassociation of the alpha-subunit with the beta-gamma-dimer and inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The RZ subfamily of RGS proteins includes RGS17, RGS19 (former GAIP), RGS20, and its splice variant Ret-RGS.


Pssm-ID: 188673  Cd Length: 118  Bit Score: 100.62  E-value: 3.03e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1489866114  64 WALSFERLLQDPLGLAYFTEFLKKEFSAENVTFWKACERFQQipASDTQQLAQEARNIYQEFLSsqALSP--VNIDRQAw 141
Cdd:cd08718     1 WAQSFDKLMKSPAGRNVFREFLRTEYSEENMLFWLACEELKK--EANKHVIEEKARLIYEDYIS--ILSPkeVSLDSRV- 75
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1489866114 142 lgEEV----LAEPRPDMFRAQQLQIFNLMKFDSYARFVKSPLYR 181
Cdd:cd08718    76 --REVinrnMLEPSPHTFDDAQLQIYTLMHRDSYPRFLNSAIYK 117
RGS_RGS19 cd08745
Regulator of G protein signaling (RGS) domain found in the RGS19 protein; The RGS (Regulator ...
64-181 3.15e-25

Regulator of G protein signaling (RGS) domain found in the RGS19 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS19 protein (also known as GAIP), a member of the RZ subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of G-protein signaling is controlled by RGS domains, which accelerate GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, resulting in a reassociation of the alpha-subunit with the beta-gamma-dimer and an inhibition of downstream activity. As a major G-protein regulator, the RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The RZ subfamily of RGS proteins includes RGS17, RGS20, and its splice variant Ret-RGS. RGS19 participates in regulation of dopamine receptor D2R and D3R, as well as beta-adrenergic receptors .


Pssm-ID: 188699  Cd Length: 118  Bit Score: 100.52  E-value: 3.15e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1489866114  64 WALSFERLLQDPLGLAYFTEFLKKEFSAENVTFWKACERFQQipASDTQQLAQEARNIYQEFLSsqALSPVNIDRQAWLG 143
Cdd:cd08745     1 WAQSFDKLMKSPAGRNVFREFLRTEYSEENMLFWLACEELKA--EANKHVIDEKARLIYEDYIS--ILSPKEVSLDSRVR 76
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1489866114 144 EEV---LAEPRPDMFRAQQLQIFNLMKFDSYARFVKSPLYR 181
Cdd:cd08745    77 EGInrkMQEPSSHTFDDAQLQIYTLMHRDSYPRFLNSPIYK 117
RGS_RGS6 cd08737
Regulator of G protein signaling (RGS) domain found in the RGS6 protein; The RGS (Regulator of ...
59-185 3.62e-25

Regulator of G protein signaling (RGS) domain found in the RGS6 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS6 protein, a member of R7 subfamily of the RGS protein family. RGS is a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). Other members of the R7 subfamily (Neuronal RGS) include: RGS7, RGS9, and RGS11, all of which are expressed predominantly in the nervous system, form an obligatory complex with G-beta-5, and play important roles in the regulation of crucial neuronal processes such as vision and motor control. Additionally they have been implicated in many neurological conditions such as anxiety, schizophrenia, and drug dependence. RGS6 exists in multiple splice isoforms with identical RGS domains, but possess complete or incomplete GGL domains and distinct N- and C-terminal domains. RGS6 interacts with SCG10, a neuronal growth-associated protein and therefore regulates neuronal differentiation. Another RGS6-binding protein is DMAP1, a component of the Dnmt1 complex involved in repression of newly replicated genes. Mutations of a critical residue required for interaction of RGS6 protein with G proteins did not affect the ability of RGS6 to interact with both SCG10 and DMAP1. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis.


Pssm-ID: 188691  Cd Length: 125  Bit Score: 100.48  E-value: 3.62e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1489866114  59 QPVASWALSFERLLQDPLGLAYFTEFLKKEFSAENVTFWKACERFQQIPASDTQQLAQEarnIYQEFLSSQALSPVNIDR 138
Cdd:cd08737     1 QRVKRWGFSLDEVLKDPVGRDQFLRFLESEFSSENLRFWLAVQDLKKQPLQDVAKRVEE---IWQEFLAPGAPSAINLDS 77
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1489866114 139 QAW-LGEEVLAEPRPDMFRAQQLQIFNLMKFDSYARFVKSPLYRECLL 185
Cdd:cd08737    78 HSYeKTSQNVKDPGRYTFEDAQEHIYKLMKSDSYARFLRSNAYQDLLL 125
RGS_RGS4 cd08714
Regulator of G protein signaling (RGS) domain found in the RGS4 protein; The RGS (Regulator of ...
68-182 1.13e-24

Regulator of G protein signaling (RGS) domain found in the RGS4 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS4 protein. RGS4 is a member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. RGS4 is expressed widely in brain including prefrontal cortex, striatum, locus coeruleus (LC), and hippocampus and has been implicated in regulation of opioid, cholinergic, and serotonergic signaling. Dysfunctions in RGS4 proteins are involved in etiology of Parkinson's disease, addiction, and schizophrenia. RGS4 also is up-regulated in the failing human heart. RGS4 interacts with many binding partners outside of GPCR pathways, including calmodulin, COP, Kir3, PIP, calcium/CaM, PA, ErbB3, and 14-3-3.


Pssm-ID: 188669  Cd Length: 114  Bit Score: 98.80  E-value: 1.13e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1489866114  68 FERLLQDPLGLAYFTEFLKKEFSAENVTFWKACERFQQIPASDtqQLAQEARNIYQEFLSSQALSPVNIDrqAWLGEEV- 146
Cdd:cd08714     1 LENLINHECGLAAFKAFLKSEYSEENIDFWVSCEDYKKTKSPS--KLSPKARKIYEEFISVQATKEVNLD--SCTREETs 76
                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1489866114 147 --LAEPRPDMFRAQQLQIFNLMKFDSYARFVKSPLYRE 182
Cdd:cd08714    77 rnMLEPTISCFDEAQKKIFTLMEKDSYRRFLKSRFYLD 114
RGS_RGS2 cd08709
Regulator of G protein signaling (RGS) domain found in the RGS2 protein; The RGS (Regulator of ...
68-182 6.80e-24

Regulator of G protein signaling (RGS) domain found in the RGS2 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS2 protein. RGS2 is a member of R4/RGS subfamily of RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G- alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS2 plays important roles in the regulation of blood pressure and the pathogenesis of human hypertension, as well as in bone formation in osteoblasts. Outside of the GPCR pathway RGS2 interacts with calmodulin, beta- COP, tubulin, PKG1-alpha, and TRPV6.


Pssm-ID: 188664  Cd Length: 114  Bit Score: 96.66  E-value: 6.80e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1489866114  68 FERLLQDPLGLAYFTEFLKKEFSAENVTFWKACERFQQIPASdtQQLAQEARNIYQEFLSSQALSPVNIDRQAW-LGEEV 146
Cdd:cd08709     1 FDELLASKYGVAAFRAFLKSEFSEENIEFWLACEDFKKTKSP--QKLTSKAKKIYTDFIEKEAPKEINIDFQTKtLIAQN 78
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1489866114 147 LAEPRPDMFRAQQLQIFNLMKFDSYARFVKSPLYRE 182
Cdd:cd08709    79 IQEATSGCFTAAQKRVYSLMENNSYPRFLESEFYQE 114
RGS_RGS1 cd08715
Regulator of G protein signaling (RGS) domain found in the RGS1 protein; The RGS (Regulator of ...
68-180 5.92e-23

Regulator of G protein signaling (RGS) domain found in the RGS1 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS1 protein. RGS1 is a member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS 1 is expressed predominantly in hematopoietic compartments, including T and B lymphocytes, and may play a major role in chemokine-mediated homing of lymphocytes to secondary lymphoid organs. In addition, RGS1 interacts with calmodulin and 14-3-3 protein outside of the GPCR pathway.


Pssm-ID: 188670  Cd Length: 114  Bit Score: 93.86  E-value: 5.92e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1489866114  68 FERLLQDPLGLAYFTEFLKKEFSAENVTFWKACERFQqipASDTQQLAQEARNIYQEFLSSQALSPVNIDRQawLGEEV- 146
Cdd:cd08715     1 LEKLLASQTGQNVFRSFLKSEFSEENIEFWLACEDYK---KTESDLLPCKAEEIYKEFVQSDAAKQINIDFR--TRESTa 75
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1489866114 147 --LAEPRPDMFRAQQLQIFNLMKFDSYARFVKSPLY 180
Cdd:cd08715    76 kkIKAPTPTCFDEAQKVIYILMERDSYPRFLKSDIY 111
RGS_RGS16 cd08710
Regulator of G protein signaling (RGS) domain found in the RGS16 protein; The RGS (Regulator ...
68-182 6.57e-23

Regulator of G protein signaling (RGS) domain found in the RGS16 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS16 protein. RGS16 is a member of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS16 is a member of the R4/RGS subfamily and interacts with neuronal G-alpha0. RGS16 expression is upregulated by IL-17 of the NF-kappaB signaling pathway in autoimmune B cells.


Pssm-ID: 188665  Cd Length: 114  Bit Score: 93.98  E-value: 6.57e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1489866114  68 FERLLQDPLGLAYFTEFLKKEFSAENVTFWKACERFQQIPASdtQQLAQEARNIYQEFLSSQALSPVNIDRQAW-LGEEV 146
Cdd:cd08710     1 FDLLLNSKNGVAAFHAFLKTEFSEENLEFWLACEEFKKIRSA--TKLASRAHHIFEEFIRSEAPKEVNIDHETReLTRTN 78
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1489866114 147 LAEPRPDMFRAQQLQIFNLMKFDSYARFVKSPLYRE 182
Cdd:cd08710    79 LQAATTSCFDVAQGKTRTLMEKDSYPRFLKSPAYRD 114
RGS_RGS8 cd08711
Regulator of G protein signaling (RGS) domain found in the RGS8 protein; The RGS (Regulator of ...
56-182 7.09e-23

Regulator of G protein signaling (RGS) domain found in the RGS8 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS8 protein. RGS8 is a member of R4/RGS subfamily of RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS8 is involved in G-protein-gated potassium channels regulation and predominantly expressed in the brain. RGS8 also is selectively expressed in the hematopoietic system (NK cells).


Pssm-ID: 188666  Cd Length: 125  Bit Score: 94.04  E-value: 7.09e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1489866114  56 TEEqpVASWALSFERLLQDPLGLAYFTEFLKKEFSAENVTFWKACERFQQipASDTQQLAQEARNIYQEFLSSQALSPVN 135
Cdd:cd08711     2 TEE--ATRWADSFDVLLSHKYGVAAFRAFLKTEFSEENLEFWLACEEFKK--TRSTAKLVSKAHRIFEEFVDVQAPREVN 77
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1489866114 136 IDRQAW-LGEEVLAEPRPDMFRAQQLQIFNLMKFDSYARFVKSPLYRE 182
Cdd:cd08711    78 IDFQTReATRKNLQEPSLTCFDQAQGKVHSLMEKDSYPRFLRSKMYLD 125
RGS_RGS3 cd08713
Regulator of G protein signaling (RGS) domain found in the RGS3 protein; The RGS (Regulator of ...
69-182 7.40e-23

Regulator of G protein signaling (RGS) domain found in the RGS3 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS3 protein. RGS3 is a member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes. RGS3 induces apoptosis when overexpressed and is involved in cell migration through interaction with the Ephrin receptor. RGS3 exits as several splice isoforms and interacts with neuroligin, estrogen receptor-alpha, and 14-3-3 outside of the GPCR pathways.


Pssm-ID: 188668  Cd Length: 114  Bit Score: 93.78  E-value: 7.40e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1489866114  69 ERLLQDPLGLAYFTEFLKKEFSAENVTFWKACERFQQIPASdtQQLAQEARNIYQEFLSSQALSPVNID-RQAWLGEEVL 147
Cdd:cd08713     2 EKLLLHKYGLAVFRAFLQTEFSEENLEFWLACEEYKKIKSQ--SKMASRAKKIFAEYIAIQSCKEVNLDsYTREHTKENL 79
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1489866114 148 AEPRPDMFRAQQLQIFNLMKFDSYARFVKSPLYRE 182
Cdd:cd08713    80 QNPTRGCFDLAQKRIYGLMEKDSYPRFLRSDLYQD 114
RGS_RGS18 cd08712
Regulator of G protein signaling (RGS) domain found in the RGS18 protein; The RGS (Regulator ...
68-180 5.12e-22

Regulator of G protein signaling (RGS) domain found in the RGS18 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS18 protein. RGS18 is a member of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS18 is a member of the R4/RGS subfamily and is expressed predominantly in osteoclasts where it acts as a negative regulator of the acidosis-induced osteoclastogenic OGR1/NFAT signaling pathway. RANKL (receptor activator of nuclear factor B ligand) stimulates osteoclastogenesis by inhibiting expression of RGS18.


Pssm-ID: 188667  Cd Length: 114  Bit Score: 91.15  E-value: 5.12e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1489866114  68 FERLLQDPLGLAYFTEFLKKEFSAENVTFWKACERFQQIPAsdTQQLAQEARNIYQEFLSSQALSPVNIDRQAwlgEEV- 146
Cdd:cd08712     1 FDKLLSHKDGLEAFTRFLKTEFSEENIEFWIACEDYKKSKT--PQQIHLKAKAIYEKFIQTDAPKEVNLDFHT---KEVt 75
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1489866114 147 ---LAEPRPDMFRAQQLQIFNLMKFDSYARFVKSPLY 180
Cdd:cd08712    76 tnsIEQPTLTSFDAAQSRVYQLMEQDSYPRFLKSDIY 112
RGS_RGS7 cd08738
Regulator of G protein signaling (RGS) domain found in the RGS7 protein; The RGS (Regulator of ...
61-182 3.24e-21

Regulator of G protein signaling (RGS) domain found in the RGS7 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS7 protein, a member of R7 subfamily of the RGS protein family. RGS is a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. Other members of the R7 subfamily (Neuronal RGS) include: RGS6, RGS9, and RGS11, all of which are expressed predominantly in the nervous system, form an obligatory complex with G-beta-5, and play important roles in the regulation of crucial neuronal processes such as vision and motor control. Additionally they have been implicated in many neurological conditions such as anxiety, schizophrenia, and drug dependence. R7 RGS proteins are key modulators of the pharmacological effects of drugs involved in the development of tolerance and addiction. In addition, RGS7 was found to bind a component of the synaptic fusion complex, snapin, and some other proteins outside of G protein signaling pathways.


Pssm-ID: 188692  Cd Length: 121  Bit Score: 89.39  E-value: 3.24e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1489866114  61 VASWALSFERLLQDPLGLAYFTEFLKKEFSAENVTFWKACERFQQIPASDTQQLAQEarnIYQEFLSSQALSPVNIDRQA 140
Cdd:cd08738     2 VKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIREVPSRVQE---IWQEFLAPGAPSAINLDSKS 78
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1489866114 141 W-LGEEVLAEPRPDMFRAQQLQIFNLMKFDSYARFVKSPLYRE 182
Cdd:cd08738    79 YdKTTQNVKDPGRYTFEDAQEHIYKLMKSDSYPRFIRSSAYQE 121
RBD cd01760
Ras-binding domain (RBD), structurally similar to a beta-grasp ubiquitin-like fold; The RBD of ...
374-444 5.40e-21

Ras-binding domain (RBD), structurally similar to a beta-grasp ubiquitin-like fold; The RBD of the serine/threonine kinase Raf is structurally similar to the beta-grasp fold of ubiquitin, a common structure involved in protein-protein interactions. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. A Raf-like RBD is also present in Regulator of G protein Signaling (RGS12 and RGS14) members of GTPase activating proteins.


Pssm-ID: 340461  Cd Length: 71  Bit Score: 86.69  E-value: 5.40e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1489866114 374 ITFELELTALERVVRISAKPTKRLQEALQPILEKHGLSPLEVVLHRPGEKQPLDLGKLVSSVAAQRLVLDT 444
Cdd:cd01760     1 NTFRLFLPNNETSVVVAVKPGKSLHEVLMPVLERHGLQLECVDVFLLGEKAPLDLNTDASSLIGQELRLDF 71
RGS_RGS21 cd08723
Regulator of G protein signaling (RGS) domain found in the RGS21 protein; The RGS (Regulator ...
71-182 6.70e-21

Regulator of G protein signaling (RGS) domain found in the RGS21 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part RGS21 protein, a member of RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, apoptosis, and cell proliferation, as well as modulation of cardiac development. RGS21 is a member of the R4/RGS subfamily and its mRNA was detected only in sensory taste cells that express sweet taste receptors and the taste G-alpha subunit, gustducin, suggesting a potential role in regulating taste transduction.


Pssm-ID: 188678  Cd Length: 111  Bit Score: 88.19  E-value: 6.70e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1489866114  71 LLQDPLGLAYFTEFLKKEFSAENVTFWKACERFQQipASDTQQLAQEARNIYQEFLSSQALSPVNIDRQAW-LGEEVLAE 149
Cdd:cd08723     1 LLANQAGLDAFRTFLKSEFSEENVEFWLACEDFKK--TKSSTEIALKAQMIYSEFIQADAPKEINIDFHTRdLISQNISE 78
                          90       100       110
                  ....*....|....*....|....*....|...
gi 1489866114 150 PRPDMFRAQQLQIFNLMKFDSYARFVKSPLYRE 182
Cdd:cd08723    79 PTLKCFDEAQSLIYCLMAKDSFPRFLKSEVYKK 111
RGS_RGS17 cd08744
Regulator of G protein signaling (RGS) domain found in the RGS17 protein; The RGS (Regulator ...
64-181 1.66e-20

Regulator of G protein signaling (RGS) domain found in the RGS17 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS17 protein, a member of the RZ subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, the RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of the G-protein signaling controlled by the RGS domain, which accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, results in reassociation of the alpha-subunit with the beta-gamma-dimer and inhibition of downstream activity. The RZ subfamily of RGS proteins includes RGS19 (former GAIP), RGS20, and its splice variant Ret-RGS. RGS17 is a relatively non-selective GAP for G-alpha-z and other G-alpha-i/o proteins. RGS17 blocks dopamine receptor-mediated inhibition of cAMP accumulation; it also blocks thyrotropin releasing hormone-stimulated Ca++ mobilization. RGS17, like other members of RZ subfamily, can act either as a GAP or as G-protein effector antogonist.


Pssm-ID: 188698  Cd Length: 118  Bit Score: 87.09  E-value: 1.66e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1489866114  64 WALSFERLLQDPLGLAYFTEFLKKEFSAENVTFWKACERFQQipASDTQQLAQEARNIYQEFLSsqALSPVNIDRQAWLG 143
Cdd:cd08744     1 WSQNFDKMMKTPAGRNLFREFLRTEYSEENLLFWLACEDLKK--EQNKKVIEEKARLIYEDYIS--ILSPKEVSLDSRVR 76
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1489866114 144 EEV---LAEPRPDMFRAQQLQIFNLMKFDSYARFVKSPLYR 181
Cdd:cd08744    77 EVInrnLLDPNPHMYEDAQLQIYTLMHRDSFPRFLNSQIYK 117
RBD smart00455
Raf-like Ras-binding domain;
303-373 2.15e-20

Raf-like Ras-binding domain;


Pssm-ID: 128731  Cd Length: 70  Bit Score: 85.03  E-value: 2.15e-20
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1489866114  303 YCCVYLPDGTASLALARPGLTIRDMLAGICEKRGLSLPDIKVYLVGnEQKALVLDQDCTVLADQEVRLENR 373
Cdd:smart00455   1 TCKVHLPDNQRTVVKVRPGKTVRDALAKALKKRGLNPECCVVRLRG-EKKPLDLNQPISSLDGQELVVEEL 70
RBD1_RGS12 cd17136
Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12); RGS12 (regulator of ...
302-371 2.99e-19

Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12); RGS12 (regulator of G protein signaling 12) is a multidomain RGS protein with numerous signaling regulatory elements. In addition to a central RGS domain which is responsible for GAP activity, the long RGS12 splice variant contains a PDZ (PSD-95/Discs-large/ZO-1 homology) domain capable of binding the interleukin-8 receptor B (CXCR2) or its own C-terminal, a phosphotyrosine-binding (PTB) domain that associates with tyrosine-phosphorylated N-type calcium channel, two tandem Ras-binding domains (RBDs) that may integrate signaling pathways involving both heterotrimeric and monomeric G-proteins, and a GoLoco (G-alpha-i/o-Loco) interaction motif which has guanine nucleotide dissociation inhibitor (GDI) activity toward G-alpha-i subunits. RBD is structurally similar to the beta-grasp fold of ubiquitin, a common structure involved in protein-protein interactions. RGS proteins belong to a large family of GTpase-accelerating proteins (GAPs) which act as key inhibitors of G-protein-mediated cell responses in eukaryotes.


Pssm-ID: 340656  Cd Length: 70  Bit Score: 81.72  E-value: 2.99e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1489866114 302 KYCCVYLPDGTASLALARPGLTIRDMLAGICEKRGLSLPDIKVYLVGNEqKALVLDQDCTVLADQEVRLE 371
Cdd:cd17136     1 KHCCVNLPDGSSCAVAIKPGVSIREMLSGLCEKLGINLAAVDLFLVGGD-KPLVLDQDSSTLESRDLRLE 69
RBD2_RGS12_like cd17067
Ras-binding domain (RBD) 2 of regulator of G protein signaling 12 (RGS12) and similar proteins; ...
373-444 4.58e-19

Ras-binding domain (RBD) 2 of regulator of G protein signaling 12 (RGS12) and similar proteins; Regulator of G-protein signaling (RGS) proteins belong to a large family of GTPase-accelerating proteins (GAPs) which act as key inhibitors of G-protein-mediated cell responses in eukaryotes. The RGS12-like subfamily is composed of RGS12 and RGS14, with multidomain architectures including a RGS domain, two tandem Ras-binding domains (RBDs), and a second Galpha interacting domain, the GoLoco motif. The RBD is structurally similar to the beta-grasp fold of ubiquitin, a common structure involved in protein-protein interactions. Ubiquitin is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair in eukaryotes.


Pssm-ID: 340587  Cd Length: 72  Bit Score: 81.45  E-value: 4.58e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1489866114 373 RITFELELTAlERVVRISAKPTKRLQEALQPILEKHGLSPLEVVLHRPGEKQPLDLGKLVSSVAAQRLVLDT 444
Cdd:cd17067     1 RVLFRLDLPN-KKIIGVKAKPTKTLAEVLRPILAKYGYKLDQVVVHLAGTQVPLDLGIPVSSIDNQRLVVET 71
RBD smart00455
Raf-like Ras-binding domain;
376-445 5.54e-19

Raf-like Ras-binding domain;


Pssm-ID: 128731  Cd Length: 70  Bit Score: 81.18  E-value: 5.54e-19
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1489866114  376 FELELTALERVVRISAKPTKRLQEALQPILEKHGLSPLEVVLHRPGEKQPLDLGKLVSSVAAQRLVLDTL 445
Cdd:smart00455   1 TCKVHLPDNQRTVVKVRPGKTVRDALAKALKKRGLNPECCVVRLRGEKKPLDLNQPISSLDGQELVVEEL 70
RGS_RGS13 cd08716
Regulator of G protein signaling (RGS) domain found in the RGS13 protein; The RGS (Regulator ...
68-182 1.26e-15

Regulator of G protein signaling (RGS) domain found in the RGS13 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS13 protein. RGS13 is member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS13 is predominantly expressed in T and B lymphocytes and in mast cells, and plays a role in adaptive immune responses. RGS13 also found in Rgs13, which is also expressed in dendritic cells and in neuroendocrine cells of the thymus, gastrointestinal, and respiratory tracts. Outside of the GPCR pathway, RGS5 interacts with the PIP3 protein.


Pssm-ID: 188671  Cd Length: 114  Bit Score: 73.04  E-value: 1.26e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1489866114  68 FERLLQDPLGLAYFTEFLKKEFSAENVTFWKACERFQQIpASDTQQLAQeARNIYQEFLSSQALSPVNID---RQAWLGE 144
Cdd:cd08716     1 FENLMATKYGPIIYATYLKTEHSDENIEFWLACETYKKI-ASQRKRISM-ARKLFASYIQPQAPREINIDsptRKAIIRN 78
                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1489866114 145 evLAEPRPDMFRAQQLQIFNLMKFDSYARFVKSPLYRE 182
Cdd:cd08716    79 --IQEPTQSCFDEAQRIVYMHMERDSYPRFLESKFYQK 114
RBD2_RGS12 cd17138
Ras-binding domain (RBD) 2 of regulator of G protein signaling 12 (RGS12); RGS12 (regulator of ...
373-443 4.67e-14

Ras-binding domain (RBD) 2 of regulator of G protein signaling 12 (RGS12); RGS12 (regulator of G-protein signaling 12) is a multidomain RGS protein with numerous signaling regulatory elements. In addition to a central RGS domain which is responsible for GAP activity, the long RGS12 splice variant contains a PDZ (PSD-95/Discs-large/ZO-1 homology) domain capable of binding the interleukin-8 receptor B (CXCR2) or its own C-terminal, a phosphotyrosine-binding (PTB) domain that associates with tyrosine-phosphorylated N-type calcium channel, two tandem Ras-binding domains (RBDs) that may integrate signaling pathways involving both heterotrimeric and monomeric G-proteins, and a GoLoco (G-alpha-i/o-Loco) interaction motif which has guanine nucleotide dissociation inhibitor (GDI) activity toward G-alpha-i subunits. RBD is structurally similar to the beta-grasp fold of ubiquitin, a common structure involved in protein-protein interactions. RGS proteins belong to a large family of GTpase-accelerating proteins (GAPs) which act as key inhibitors of G-protein-mediated cell responses in eukaryotes.


Pssm-ID: 340658  Cd Length: 73  Bit Score: 67.25  E-value: 4.67e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1489866114 373 RITFELELTALERVVRISAKPTKRLQEALQPILEKHGLSPLEVVLHRPGEKQPLDLGKLVSSVAAQRLVLD 443
Cdd:cd17138     1 RTLFRLDLVPINRSVGLKAKPTKPVTEVLRPVVAKYGLNLNELVARISGEKEPLDLGLPISNLDGQRVVLE 71
RGS_AKAP2_2 cd08721
Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, ...
71-180 8.63e-11

Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, D-AKAP2; The RGS (Regulator of G-protein Signaling) domain is an essential part of the D-AKAP2 (A-kinase anchoring protein), a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. D-AKAP2 contains two RGS domains which play an important role in spatiotemporal localization of cAMP-dependent PKA (cyclic AMP-dependent protein kinase) that regulates many different signaling pathways by phosphorylation of target proteins. This cd contains the second RGS domain.


Pssm-ID: 188676  Cd Length: 121  Bit Score: 59.28  E-value: 8.63e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1489866114  71 LLQDPLgLAYFTEFLKKEFSAENVTFWKACERFQ-QIPASDTQQLAQEARN----IYQEFLSSQALSPVNIDRQAWLGEE 145
Cdd:cd08721     2 LYCESA-LFYFMEYMEQEGARNLLQFWLAADNFQsQLAAKEGQYDGQQAQNdamiIYDKYFSLQATEPLGFDDKTRLEVE 80
                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1489866114 146 --VLAE--PRPDMFRAQQLQIFNLMKFDSYARFVKSPLY 180
Cdd:cd08721    81 snICREggPLPSCFEAPLLQALTTLEQHYLPGFLSSQLY 119
RGS_Axin cd08707
Regulator of G protein signaling (RGS) domain found in the Axin protein; The RGS (Regulator of ...
71-182 2.36e-09

Regulator of G protein signaling (RGS) domain found in the Axin protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the Axin protein. Axin is a member of the RA/RGS subfamily of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, and skeletal and muscle development. The RGS domain of Axin is specifically interacts with the heterotrimeric G-alpha12 protein, but not with closely related G-alpha13, and provides a unique tool to regulate G-alpha12-mediated signaling processes. The RGS domain of Axin also interacts with the tumor suppressor protein APC (Adenomatous Polyposis Coli) in order to control the cytoplasmic level of the proto-oncogene, beta-catenin.


Pssm-ID: 188662  Cd Length: 117  Bit Score: 55.16  E-value: 2.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1489866114  71 LLQDPLGLAYFTEFLKKEFSAENVTFWKACERFQQIPASDTQQlAQEARNIYQEFLSSQALSPVNIDRQ--AWLGEEVLA 148
Cdd:cd08707     4 LLDDQDGIELFRTYLEQEGCADLLDFWFACNGFRKMSDSEEKR-SKLAKAIYRRYIKDNGIVSRQLKPAtkSFIKECIKK 82
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1489866114 149 EP-RPDMFRAQQLQIFNLMKFDSYARFVKSPLYRE 182
Cdd:cd08707    83 QQlDPAMFDQAQTEIQTTMEENTYPSFLKSDIYLE 117
RGS_SNX13 cd08719
Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 13 (SNX13) protein; ...
72-180 6.34e-08

Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 13 (SNX13) protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the SNX13 (Sorting Nexin 13) protein, a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. The RGS-domain of SNX13 plays a major role through attenuation of Galphas-mediated signaling and regulates endocytic trafficking and degradation of the epidermal growth factor receptor. Snx13-null mice were embryonic lethal around midgestation which supports an essential role for SNX13 in mouse development and regulation of endocytosis dynamics.


Pssm-ID: 188674  Cd Length: 135  Bit Score: 51.65  E-value: 6.34e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1489866114  72 LQDPLGLAYFTEFLKKEFSAENVTFWKACERF-----QQIPASDTQQLAQE-------------ARNIYQEFLSSQALSP 133
Cdd:cd08719     2 LVNNVALSYFIDFMQSVGGQAYLFFWLTVEGYrvsaeQQLSELHLRQRGGEhqrsdvyemlraaALNIYDQYLSEKASPR 81
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1489866114 134 VNIDRQ---AWLGEEVLAEPRPDMFRAQQLQIFNLMKFDS--YARFVKSPLY 180
Cdd:cd08719    82 VPLDDSlvkKLLNRLRNDTPSDLWFDDIQQKVFDIMQEDErfYPAFKKSPAY 133
RBD cd01760
Ras-binding domain (RBD), structurally similar to a beta-grasp ubiquitin-like fold; The RBD of ...
302-371 1.39e-07

Ras-binding domain (RBD), structurally similar to a beta-grasp ubiquitin-like fold; The RBD of the serine/threonine kinase Raf is structurally similar to the beta-grasp fold of ubiquitin, a common structure involved in protein-protein interactions. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. A Raf-like RBD is also present in Regulator of G protein Signaling (RGS12 and RGS14) members of GTPase activating proteins.


Pssm-ID: 340461  Cd Length: 71  Bit Score: 48.94  E-value: 1.39e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1489866114 302 KYCCVYLPDGTASLALA-RPGLTIRDMLAGICEKRGLSLPDIKVYLVGnEQKALVLDQDCTVLADQEVRLE 371
Cdd:cd01760     1 NTFRLFLPNNETSVVVAvKPGKSLHEVLMPVLERHGLQLECVDVFLLG-EKAPLDLNTDASSLIGQELRLD 70
RGS_SNX25 cd08720
Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 25 (SNX25) protein; ...
71-182 4.34e-06

Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 25 (SNX25) protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the SNX25 (Sorting Nexin 25) protein, a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. SNX25 is a member of the Dopamine receptors (DAR) signalplex and regulates the trafficking of D1 and D2 DARs.


Pssm-ID: 188675  Cd Length: 110  Bit Score: 45.87  E-value: 4.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1489866114  71 LLQDPLGLAYFTEFLKKEFSAENVTFWKACERFQQIPASDTQQLAQEarnIYQEFLSSQAlSPVNIDRQAWLGEE--VLA 148
Cdd:cd08720     1 ILANVFGRKYLSQFLERMDSQALIGFWEAVEELRSANKSEWHQLGAE---IFYTFIVEPT-AEIKVDKSLRKRIEqfLLG 76
                          90       100       110
                  ....*....|....*....|....*....|....
gi 1489866114 149 EPRPDMFRAQQLQIFNLMKFDSYARFVKSPLYRE 182
Cdd:cd08720    77 DKGPEVFYEVQENVVETLEEKYYPSFVVSDQYKQ 110
RGS_FLBA cd08708
Regulator of G protein signaling (RGS) domain found in the FLBA (Fluffy Low BrlA) protein; The ...
69-180 1.27e-05

Regulator of G protein signaling (RGS) domain found in the FLBA (Fluffy Low BrlA) protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the FLBA (Fluffy Low BrlA) protein. FLBA is a member of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins play a critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of the G-protein signaling controlled by the RGS domain accelerates the GTPase activity of the alpha subunit by hydrolysis of GTP to GDP which results in reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes. The RGS domain of the FLBA protein antagonizes G protein signaling to block proliferation and allow development. It is required for control of mycelial proliferation and activation of asexual sporulation in yeast.


Pssm-ID: 188663  Cd Length: 148  Bit Score: 45.45  E-value: 1.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1489866114  69 ERLLQDPlGLAY-FTEFLKKEFSAENVTFWKACERFQ-----------------QIPASDTQQLAQeARNIYQEFLSSQA 130
Cdd:cd08708     3 DKILKDP-GLRYlFREHLEKEFCEENLSFYLEVKEFLkkmtilsklldfkssqaADEDLDRESLAQ-AYHIYNTYLAPGS 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1489866114 131 LSPVNIDRQawLGEEV---LAEPRP--DMFRAQQLQIF-------------NLMKFDSYARFVKSPLY 180
Cdd:cd08708    81 PCELNIDHN--LRNRIttiMTEKIVgeDDSMAESLQGVealfeeaqnavfkPLMAGDSVPKFLKQPEY 146
RBD_PLEKHG5 cd17068
Ras-binding domain (RBD) found in pleckstrin homology (PH) and RhoGEF domain containing G5 ...
318-370 1.85e-05

Ras-binding domain (RBD) found in pleckstrin homology (PH) and RhoGEF domain containing G5 (PLEKHG5) and similar proteins; PLEKHG5, is also termed PH domain-containing family G member 5, or guanine nucleotide exchange factor 720 (GEF720), Syx, or Tech, is a novel Dbl-like protein related to p115Rho-GEF. It functions as a Rho guanine nucleotide exchange factor directly activating RhoA in vivo and potentially involved in the control of neuronal cell differentiation. It also regulates the balance of the RhoA downstream effector Dia and ROCK activities to promote polarized-cancer-cell migration. Moreover, PLEKHG5 activates the nuclear factor kappaB (NFkappaB) signaling pathway. Mutations in the PLEKHG5 gene are relevant with autosomal recessive intermediate Charcot-Marie-Tooth disease (CMT) and lower motor neuron disease (LMND).


Pssm-ID: 340588  Cd Length: 75  Bit Score: 42.95  E-value: 1.85e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1489866114 318 ARPGLTIRDMLAGICEKRGLSLPDIKVYLVGNeQKALVLDQDCTVLADQEVRL 370
Cdd:cd17068    21 AVKGKTLRDVLEPLLERRGLDLDRVNVFLDSS-NTPLPLEFDTYFLGGHTLRV 72
RGS_RGS22_4 cd08725
Regulator of G protein signaling domain RGS_RGS22_4; The RGS (Regulator of G-protein Signaling) ...
72-174 3.73e-05

Regulator of G protein signaling domain RGS_RGS22_4; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis.


Pssm-ID: 188680  Cd Length: 123  Bit Score: 43.53  E-value: 3.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1489866114  72 LQDPLGLAYFTEF--LKKEFSAENVTFWKACERFQQ--IPASDTQQLAQEARNIYQEFLSSQALSPVNIDRQAWLGEEVL 147
Cdd:cd08725     1 LLNPVTSEQFQRFvsLKGEELENDLLFWLEVQKYKDlcHSHSDEHIIQNKITAIISCFIDSSVPPALQIDIPPEIANRIL 80
                          90       100       110
                  ....*....|....*....|....*....|
gi 1489866114 148 A---EPRPDMFRAQQLQIFNLMkFDSYARF 174
Cdd:cd08725    81 EhrrELGPYIFREAQLTVFRVL-FKYWAGF 109
RBD_RAF cd01816
Ras-binding domain (RBD) found in RAF family serine/threonine kinases; The RAF family includes ...
306-371 4.19e-05

Ras-binding domain (RBD) found in RAF family serine/threonine kinases; The RAF family includes three RAF serine/threonine kinases ARAF, BRAF, and RAF1/CRAF. These are encoded by proto-oncogenes, and activate the mitogen-activated protein kinase/extracellular-signal-regulated kinase (MAPK/ERK) cascade downstream of RAS. They share a common structure consisting of an N-terminal regulatory domain and a C-terminal kinase domain. There are three conserved regions (CR1-3) in the regulatory domain, CR1 contains a Ras-binding domain (RBD) and a cysteine-rich domain (CRD), CR2 is a serine/threonine-rich domain, and CR3 encodes the kinase domain required for RAF. The RBD of RAF has a beta-grasp ubiquitin-like fold, a common structure involved in protein-protein interactions.


Pssm-ID: 340514  Cd Length: 71  Bit Score: 41.79  E-value: 4.19e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1489866114 306 VYLPDGTASLALARPGLTIRDMLAGICEKRGLSLPDIKVYLVGNeqKALVL-DQDCTVLADQEVRLE 371
Cdd:cd01816     5 AHLPNQQRTTVEVKPGQTLREALEKAMKRRGLTPEMCVVYRKGT--REPVSwDTDISTLEGEEISVE 69
RGS_PX cd08729
Regulator of G protein signaling domain; These uncharacterized RGS-like domains are found in ...
72-180 8.73e-05

Regulator of G protein signaling domain; These uncharacterized RGS-like domains are found in proteins that also contain one or more PX domains. The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. As a major G-protein regulator, the RGS domain containing proteins that are involves in many crucial cellular processes. RGS proteins regulate intracellular trafficking and provide vital support for signal transduction. RGS proteins play critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. Several RGS proteins can fine-tune immune responses, others RGS proteins play important role in neuronal signals modulation. Some RGS proteins are the principal elements needed for proper vision.


Pssm-ID: 188684  Cd Length: 136  Bit Score: 42.84  E-value: 8.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1489866114  72 LQDPLGLAYFTEFLKKEFSAENVTFWKACERFQ--------------QIPASDTQQLAQEARNIYQEFLSSQ----ALSP 133
Cdd:cd08729     1 LRDPSSLSYFMEFMDRRNRSQLVQFWLVVEGFKnpledtendysldsSQSRSWIDSDKEDIAMIYETYFSDPspslNVPK 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1489866114 134 ---------VNIDRQAWLGEEVlAEPRPDMFRAQQlQIFNLMKFDSYARFVKSPLY 180
Cdd:cd08729    81 asrdpirlfLNAGVNASPNEQY-RKARRAVLMAQR-AVYEEMEEEDFPEFKKSELF 134
RGS-like_1 cd08734
Uncharacterized Regulator of G protein Signaling (RGS) domain subfamily, child 1; These ...
81-136 1.56e-04

Uncharacterized Regulator of G protein Signaling (RGS) domain subfamily, child 1; These uncharacterized RGS-like domains consists largely of hypothetical proteins. The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. As a major G-protein regulator, the RGS domain containing proteins that are involved in many crucial cellular processes. RGS proteins play critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play an important role in neuronal signal modulation. Some RGS proteins are the principal elements needed for proper vision.


Pssm-ID: 188688  Cd Length: 109  Bit Score: 41.30  E-value: 1.56e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1489866114  81 FTEFLKKEFSAENVTFWKACERFQQIPASDTQQLAqeARNIYQEFLSSQALSPVNI 136
Cdd:cd08734     8 FGFSAESDFSGENLSFLTLVKEYKRLSNPAEKFTL--ASKIYKEFISSESPFQINI 61
GoLoco pfam02188
GoLoco motif;
500-521 1.28e-03

GoLoco motif;


Pssm-ID: 460481  Cd Length: 22  Bit Score: 36.24  E-value: 1.28e-03
                          10        20
                  ....*....|....*....|..
gi 1489866114 500 EGLVELLNRVQSSGAHDQRGLL 521
Cdd:pfam02188   1 EDFFDLLARVQSSRLDDQRCSL 22
GoLoco smart00390
LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins
499-521 1.54e-03

LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins


Pssm-ID: 214645  Cd Length: 23  Bit Score: 35.94  E-value: 1.54e-03
                           10        20
                   ....*....|....*....|...
gi 1489866114  499 IEGLVELLNRVQSSGAHDQRGLL 521
Cdd:smart00390   1 DEDLFDLLLRMQSSRMDDQRCEL 23
RBD2_RGS12_like cd17067
Ras-binding domain (RBD) 2 of regulator of G protein signaling 12 (RGS12) and similar proteins; ...
305-373 5.17e-03

Ras-binding domain (RBD) 2 of regulator of G protein signaling 12 (RGS12) and similar proteins; Regulator of G-protein signaling (RGS) proteins belong to a large family of GTPase-accelerating proteins (GAPs) which act as key inhibitors of G-protein-mediated cell responses in eukaryotes. The RGS12-like subfamily is composed of RGS12 and RGS14, with multidomain architectures including a RGS domain, two tandem Ras-binding domains (RBDs), and a second Galpha interacting domain, the GoLoco motif. The RBD is structurally similar to the beta-grasp fold of ubiquitin, a common structure involved in protein-protein interactions. Ubiquitin is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair in eukaryotes.


Pssm-ID: 340587  Cd Length: 72  Bit Score: 36.00  E-value: 5.17e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1489866114 305 CVYLPDGTASLALARPGLTIRDMLAGICEKRGLSLPDIKVYLVGNEQkalVLDQDCTV--LADQEVRLENR 373
Cdd:cd17067     5 RLDLPNKKIIGVKAKPTKTLAEVLRPILAKYGYKLDQVVVHLAGTQV---PLDLGIPVssIDNQRLVVETK 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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