NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1537718555|ref|NP_001354719|]
View 

transcription elongation factor A protein-like 6 isoform 1 [Homo sapiens]

Protein Classification

BEX domain-containing protein( domain architecture ID 10517751)

BEX domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
BEX pfam04538
Brain expressed X-linked like family; This is a family of transcription elongation factors ...
 81-175 1.12e-21

Brain expressed X-linked like family; This is a family of transcription elongation factors which includes those referred to as Bex proteins as well as those named TCEAL7. Bex1 was shown to be a novel link between neurotrophin signalling, the cell cycle, and neuronal differentiation, suggesting it might function by coordinating internal cellular states with the ability of cells to respond to external signals. TCEAL7 has been shown negatively to regulate the NF-kappaB pathway, hence being important in ovarian cancer as it one of the genes frequently downregulated in this cancer. A closely related protein, TFIIS/TCEA, found in pfam07500 is involved in transcription elongation and transcript fidelity. TFIIS/TCEA promotes 3' endoribonuclease activity of RNA polymerase II (pol II) and allows pol II to bypass transcript pause or 'arrest' during elongation process. It is thus possible that BEX is also acting in this way.


:

Pssm-ID: 461346 [Multi-domain]  Cd Length: 103  Bit Score: 85.00  E-value: 1.12e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1537718555  81 EGKPASQAKPEGQPraaEKRPAGDYVPRKAKRKTDRG-TDDSPKDSQEDLQERHLSSEEMMRECGDVSRAQEELRK-KQK 158
Cdd:pfam04538   9 EGKPEEQGKVENEE---EPEDLEGGEPRKPRGNTRRGrVRQSVPNFREDIPNRHLSPEEMMREGDDMERFGEEMRElRQK 85

                          90
                  ....*....|....*..
gi 1537718555 159 MGGFHWMQRDVQDPFAP 175
Cdd:pfam04538  86 LREQQWRQRPHRDHHYP 102
2A1904 super family cl36772
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 7-145 3.69e-07

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


The actual alignment was detected with superfamily member TIGR00927:

Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 49.61  E-value: 3.69e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1537718555    7 KNEGNLENEGKPEDEVEPDDEGKSDEEEKPDAEGKTECEGKRKAEGEPGDEGQLEDKGSQEKQG-KSEGEGKPQGEGKPA 85
Cdd:TIGR00927  662 ESGGEAEQEGETETKGENESEGEIPAERKGEQEGEGEIEAKEADHKGETEAEEVEHEGETEAEGtEDEGEIETGEEGEEV 741

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1537718555   86 SQakpEGQPRAAekrpAGDYVPRKAKRKTDRGTDDSPKDSQEDLQERHLSSEEMMRECGD 145
Cdd:TIGR00927  742 ED---EGEGEAE----GKHEVETEGDRKETEHEGETEAEGKEDEDEGEIQAGEDGEMKGD 794
 
Name Accession Description Interval E-value
BEX pfam04538
Brain expressed X-linked like family; This is a family of transcription elongation factors ...
 81-175 1.12e-21

Brain expressed X-linked like family; This is a family of transcription elongation factors which includes those referred to as Bex proteins as well as those named TCEAL7. Bex1 was shown to be a novel link between neurotrophin signalling, the cell cycle, and neuronal differentiation, suggesting it might function by coordinating internal cellular states with the ability of cells to respond to external signals. TCEAL7 has been shown negatively to regulate the NF-kappaB pathway, hence being important in ovarian cancer as it one of the genes frequently downregulated in this cancer. A closely related protein, TFIIS/TCEA, found in pfam07500 is involved in transcription elongation and transcript fidelity. TFIIS/TCEA promotes 3' endoribonuclease activity of RNA polymerase II (pol II) and allows pol II to bypass transcript pause or 'arrest' during elongation process. It is thus possible that BEX is also acting in this way.


Pssm-ID: 461346 [Multi-domain]  Cd Length: 103  Bit Score: 85.00  E-value: 1.12e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1537718555  81 EGKPASQAKPEGQPraaEKRPAGDYVPRKAKRKTDRG-TDDSPKDSQEDLQERHLSSEEMMRECGDVSRAQEELRK-KQK 158
Cdd:pfam04538   9 EGKPEEQGKVENEE---EPEDLEGGEPRKPRGNTRRGrVRQSVPNFREDIPNRHLSPEEMMREGDDMERFGEEMRElRQK 85

                          90
                  ....*....|....*..
gi 1537718555 159 MGGFHWMQRDVQDPFAP 175
Cdd:pfam04538  86 LREQQWRQRPHRDHHYP 102
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 7-145 3.69e-07

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 49.61  E-value: 3.69e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1537718555    7 KNEGNLENEGKPEDEVEPDDEGKSDEEEKPDAEGKTECEGKRKAEGEPGDEGQLEDKGSQEKQG-KSEGEGKPQGEGKPA 85
Cdd:TIGR00927  662 ESGGEAEQEGETETKGENESEGEIPAERKGEQEGEGEIEAKEADHKGETEAEEVEHEGETEAEGtEDEGEIETGEEGEEV 741

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1537718555   86 SQakpEGQPRAAekrpAGDYVPRKAKRKTDRGTDDSPKDSQEDLQERHLSSEEMMRECGD 145
Cdd:TIGR00927  742 ED---EGEGEAE----GKHEVETEGDRKETEHEGETEAEGKEDEDEGEIQAGEDGEMKGD 794
PRK13108 PRK13108
prolipoprotein diacylglyceryl transferase; Reviewed
 13-112 2.96e-03

prolipoprotein diacylglyceryl transferase; Reviewed


Pssm-ID: 237284 [Multi-domain]  Cd Length: 460  Bit Score: 37.65  E-value: 2.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1537718555  13 ENEGKPEDEVEPDDEGKSDEE---EKPdAEGKTECEGKRKAEGEPGDEGQlEDKGSQEKQGKSEGEGKPqGEGKP--ASQ 87
Cdd:PRK13108  358 ESTPAVEETSEADIEREQPGDlagQAP-AAHQVDAEAASAAPEEPAALAS-EAHDETEPEVPEKAAPIP-DPAKPdeLAV 434

                          90       100
                  ....*....|....*....|....*
gi 1537718555  88 AKPEGQPRAAEKRPAGDYVPRKAKR 112
Cdd:PRK13108  435 AGPGDDPAEPDGIRRQDDFSSRRRR 459
PTZ00121 PTZ00121
MAEBL; Provisional
 14-159 8.92e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 36.66  E-value: 8.92e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1537718555   14 NEGKPEDEVEPDDEGKSDEEEKPDAEGKTECEGKRKAEgEPGDEGQLEDKGSQEKQGKSEGEGKPQGEGKPASQAKPEGQ 93
Cdd:PTZ00121  1281 DELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKAD-EAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEA 1359

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1537718555   94 PRAAEKRPAGDYVPRKAKRKTDRGTDDSPKDSQEDlqERHLSSEEMMRECGDVSRAQEELRKKQKM 159
Cdd:PTZ00121  1360 EAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKAD--EAKKKAEEDKKKADELKKAAAAKKKADEA 1423
 
Name Accession Description Interval E-value
BEX pfam04538
Brain expressed X-linked like family; This is a family of transcription elongation factors ...
 81-175 1.12e-21

Brain expressed X-linked like family; This is a family of transcription elongation factors which includes those referred to as Bex proteins as well as those named TCEAL7. Bex1 was shown to be a novel link between neurotrophin signalling, the cell cycle, and neuronal differentiation, suggesting it might function by coordinating internal cellular states with the ability of cells to respond to external signals. TCEAL7 has been shown negatively to regulate the NF-kappaB pathway, hence being important in ovarian cancer as it one of the genes frequently downregulated in this cancer. A closely related protein, TFIIS/TCEA, found in pfam07500 is involved in transcription elongation and transcript fidelity. TFIIS/TCEA promotes 3' endoribonuclease activity of RNA polymerase II (pol II) and allows pol II to bypass transcript pause or 'arrest' during elongation process. It is thus possible that BEX is also acting in this way.


Pssm-ID: 461346 [Multi-domain]  Cd Length: 103  Bit Score: 85.00  E-value: 1.12e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1537718555  81 EGKPASQAKPEGQPraaEKRPAGDYVPRKAKRKTDRG-TDDSPKDSQEDLQERHLSSEEMMRECGDVSRAQEELRK-KQK 158
Cdd:pfam04538   9 EGKPEEQGKVENEE---EPEDLEGGEPRKPRGNTRRGrVRQSVPNFREDIPNRHLSPEEMMREGDDMERFGEEMRElRQK 85

                          90
                  ....*....|....*..
gi 1537718555 159 MGGFHWMQRDVQDPFAP 175
Cdd:pfam04538  86 LREQQWRQRPHRDHHYP 102
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 7-145 3.69e-07

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 49.61  E-value: 3.69e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1537718555    7 KNEGNLENEGKPEDEVEPDDEGKSDEEEKPDAEGKTECEGKRKAEGEPGDEGQLEDKGSQEKQG-KSEGEGKPQGEGKPA 85
Cdd:TIGR00927  662 ESGGEAEQEGETETKGENESEGEIPAERKGEQEGEGEIEAKEADHKGETEAEEVEHEGETEAEGtEDEGEIETGEEGEEV 741

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1537718555   86 SQakpEGQPRAAekrpAGDYVPRKAKRKTDRGTDDSPKDSQEDLQERHLSSEEMMRECGD 145
Cdd:TIGR00927  742 ED---EGEGEAE----GKHEVETEGDRKETEHEGETEAEGKEDEDEGEIQAGEDGEMKGD 794
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 2-145 2.13e-06

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 47.30  E-value: 2.13e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1537718555    2 EKPYNKNEGNLENEGKPEDEVEPDDEGKS------DEEEKPDAEGKTECEG-KRKAEGEPGDEGQL-EDKGSQEKQGKSE 73
Cdd:TIGR00927  675 TKGENESEGEIPAERKGEQEGEGEIEAKEadhkgeTEAEEVEHEGETEAEGtEDEGEIETGEEGEEvEDEGEGEAEGKHE 754

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1537718555   74 GEGK--------PQGEGKPASQAKPEGQPRAAEKRPAGDYVPRKAKRKTDRGTDDSPKDSQEDLQERHLSSEEMMRECGD 145
Cdd:TIGR00927  755 VETEgdrketehEGETEAEGKEDEDEGEIQAGEDGEMKGDEGAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDETGE 834
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 19-107 7.85e-04

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 39.59  E-value: 7.85e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1537718555   19 EDEVEPDDEGKSDEEEKpDAEGKTECEGKRKAEGEPGDEGQLEDKGSQEKQGKSEGEGKPQGEGKPASQAK---PEGQPR 95
Cdd:TIGR00927  633 GDVAEAEHTGERTGEEG-ERPTEAEGENGEESGGEAEQEGETETKGENESEGEIPAERKGEQEGEGEIEAKeadHKGETE 711

                           90
                   ....*....|..
gi 1537718555   96 AAEKRPAGDYVP 107
Cdd:TIGR00927  712 AEEVEHEGETEA 723
PRK13108 PRK13108
prolipoprotein diacylglyceryl transferase; Reviewed
 13-112 2.96e-03

prolipoprotein diacylglyceryl transferase; Reviewed


Pssm-ID: 237284 [Multi-domain]  Cd Length: 460  Bit Score: 37.65  E-value: 2.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1537718555  13 ENEGKPEDEVEPDDEGKSDEE---EKPdAEGKTECEGKRKAEGEPGDEGQlEDKGSQEKQGKSEGEGKPqGEGKP--ASQ 87
Cdd:PRK13108  358 ESTPAVEETSEADIEREQPGDlagQAP-AAHQVDAEAASAAPEEPAALAS-EAHDETEPEVPEKAAPIP-DPAKPdeLAV 434

                          90       100
                  ....*....|....*....|....*
gi 1537718555  88 AKPEGQPRAAEKRPAGDYVPRKAKR 112
Cdd:PRK13108  435 AGPGDDPAEPDGIRRQDDFSSRRRR 459
PTZ00121 PTZ00121
MAEBL; Provisional
 14-159 8.92e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 36.66  E-value: 8.92e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1537718555   14 NEGKPEDEVEPDDEGKSDEEEKPDAEGKTECEGKRKAEgEPGDEGQLEDKGSQEKQGKSEGEGKPQGEGKPASQAKPEGQ 93
Cdd:PTZ00121  1281 DELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKAD-EAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEA 1359

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1537718555   94 PRAAEKRPAGDYVPRKAKRKTDRGTDDSPKDSQEDlqERHLSSEEMMRECGDVSRAQEELRKKQKM 159
Cdd:PTZ00121  1360 EAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKAD--EAKKKAEEDKKKADELKKAAAAKKKADEA 1423
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH