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Conserved domains on  [gi|1546278268|ref|NP_001354869|]
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LBH domain-containing protein 1 isoform a [Homo sapiens]

Protein Classification

Lbh domain-containing protein( domain architecture ID 10633915)

Lbh domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Lbh pfam15317
Cardiac transcription factor regulator, Developmental protein; The family of proteins are ...
 1-128 5.52e-29

Cardiac transcription factor regulator, Developmental protein; The family of proteins are cardiac transcription regulators, named Lbh, short for Limb, bud and heart. They regulate embryological development in the heart. More specifically, in humans, they may act as transcriptional activators in MAPK signaling pathway to mediate cellular functions. This family of proteins is found in eukaryotes. Proteins in this family are typically between 92 and 116 amino acids in length.


:

Pssm-ID: 434627  Cd Length: 101  Bit Score: 106.55  E-value: 5.52e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546278268   1 MALVPGRSkEDGLWTRNSPGSSQHPESPRLPNPLW-DRGKIGKVEGHQHIQVStssacvwqlayppvwpnlpavpiqdfs 79
Cdd:pfam15317   1 MALVPGNS-EDGPWPMDSPGSSQHPESPRLSNPLFkDRGEIDRVEKLQDIQVS--------------------------- 52

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1546278268  80 QKSHLPSIVVESSEVNE-ESGDLHLPHEELLLLTDGeEEDAEAFFQDQSE 128
Cdd:pfam15317  53 QKTRLPSIVVEASEVGEeESGELRWPHEELLVLTDG-EEEAEAFFQDQSE 101
 
Name Accession Description Interval E-value
Lbh pfam15317
Cardiac transcription factor regulator, Developmental protein; The family of proteins are ...
 1-128 5.52e-29

Cardiac transcription factor regulator, Developmental protein; The family of proteins are cardiac transcription regulators, named Lbh, short for Limb, bud and heart. They regulate embryological development in the heart. More specifically, in humans, they may act as transcriptional activators in MAPK signaling pathway to mediate cellular functions. This family of proteins is found in eukaryotes. Proteins in this family are typically between 92 and 116 amino acids in length.


Pssm-ID: 434627  Cd Length: 101  Bit Score: 106.55  E-value: 5.52e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546278268   1 MALVPGRSkEDGLWTRNSPGSSQHPESPRLPNPLW-DRGKIGKVEGHQHIQVStssacvwqlayppvwpnlpavpiqdfs 79
Cdd:pfam15317   1 MALVPGNS-EDGPWPMDSPGSSQHPESPRLSNPLFkDRGEIDRVEKLQDIQVS--------------------------- 52

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1546278268  80 QKSHLPSIVVESSEVNE-ESGDLHLPHEELLLLTDGeEEDAEAFFQDQSE 128
Cdd:pfam15317  53 QKTRLPSIVVEASEVGEeESGELRWPHEELLVLTDG-EEEAEAFFQDQSE 101
 
Name Accession Description Interval E-value
Lbh pfam15317
Cardiac transcription factor regulator, Developmental protein; The family of proteins are ...
 1-128 5.52e-29

Cardiac transcription factor regulator, Developmental protein; The family of proteins are cardiac transcription regulators, named Lbh, short for Limb, bud and heart. They regulate embryological development in the heart. More specifically, in humans, they may act as transcriptional activators in MAPK signaling pathway to mediate cellular functions. This family of proteins is found in eukaryotes. Proteins in this family are typically between 92 and 116 amino acids in length.


Pssm-ID: 434627  Cd Length: 101  Bit Score: 106.55  E-value: 5.52e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546278268   1 MALVPGRSkEDGLWTRNSPGSSQHPESPRLPNPLW-DRGKIGKVEGHQHIQVStssacvwqlayppvwpnlpavpiqdfs 79
Cdd:pfam15317   1 MALVPGNS-EDGPWPMDSPGSSQHPESPRLSNPLFkDRGEIDRVEKLQDIQVS--------------------------- 52

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1546278268  80 QKSHLPSIVVESSEVNE-ESGDLHLPHEELLLLTDGeEEDAEAFFQDQSE 128
Cdd:pfam15317  53 QKTRLPSIVVEASEVGEeESGELRWPHEELLVLTDG-EEEAEAFFQDQSE 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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