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Conserved domains on  [gi|1607220055|ref|NP_001356276|]
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putative Polycomb group protein ASXL2 isoform 3 [Homo sapiens]

Protein Classification

ASXH and PHD_3 domain-containing protein( domain architecture ID 10621630)

ASXH and PHD_3 domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ASXH pfam13919
Asx homology domain; A conserved alpha helical domain with a characteriztic LXXLL motif. The ...
2-120 1.05e-39

Asx homology domain; A conserved alpha helical domain with a characteriztic LXXLL motif. The LXXLL motif is detected in diverse transcription factors, coactivators and corepressors and is implicated in mediating interactions between them. The ASXH domain is found in animals, fungi and plants and is predicted to play a role in mediating contact between transcription factors and chromatin-associated complexes. In Drosophila Asx and Human ASXL1, the ASXH domain is predicted to mediate interactions with the Calypso and BAP1 deubiquitinases (DUBs) which further belong to the UCHL5/UCH37 clade of DUBs.


:

Pssm-ID: 464041  Cd Length: 129  Bit Score: 143.20  E-value: 1.05e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1607220055    2 KRTKCADIDVETPDSILVNTNLRALINKHTFSVLPGDCQQRLLLLLPEVDRQVGPDGLMKLN--GSALNNEFFTSAAQGW 79
Cdd:pfam13919    8 KGKWEAEILLTSPKSPLVNADLRALLNKAAWDCLPPEEQQELLSLLPDVDHILDPDTDDSRPalPSLRNNEFFRHACARF 87
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1607220055   80 KERLSEGEFTPEMQVRIRQEIEKEK-KVEPWKEQFFESYYGQ 120
Cdd:pfam13919   88 QEDLAEGRFDPELRQAWKAEEKREAgKFDPWKEKEFEEFWGQ 129
PHD_3 pfam13922
PHD domain of transcriptional enhancer, Asx; This is the DNA-binding domain on the additional ...
1113-1173 1.64e-26

PHD domain of transcriptional enhancer, Asx; This is the DNA-binding domain on the additional sex combs-like 1 proteins. The Asx protein acts as an enhancer of trithorax and polycomb in displaying bidirectional homoeotic phenotypes in Drosophila, suggesting that it is required for maintenance of both activation and silencing of Hox genes. Asx is required for normal adult haematopoiesis and its function depends on its cellular context.


:

Pssm-ID: 316444  Cd Length: 68  Bit Score: 103.44  E-value: 1.64e-26
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1607220055 1113 MNPSSHGQTIPVQAFSEE-------NSIEGTPSKCYCRLKAMIMCKGCGAFCHDDCIGPSKLCVSCLV 1173
Cdd:pfam13922    1 QNPQQQQQHPLLQLAHQSgentppgNEATHTANKCACRLNAMVICQQCGAFCHDDCIGASKLCVSCVI 68
PHA03247 super family cl33720
large tegument protein UL36; Provisional
484-724 9.54e-06

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.32  E-value: 9.54e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1607220055  484 LPCGPETQPQSETKTTPSQAQPHSVSGAQLQQTPPVPPTPAVSGACTSVPSPAHIEKLDNEKLNPTRATATVASVSHPQG 563
Cdd:PHA03247  2750 TPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLP 2829
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1607220055  564 PSSCRQEKAPSPTGPALISGASPVHCAADGTVELKAGPSKNIP-NPSASSKTDASVPVAVTPSPLTSLLTTATLEKLPVP 642
Cdd:PHA03247  2830 PPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAaKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPP 2909
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1607220055  643 QVSATTAPAGSAPPSSTLPAASSLKTPGTSLNMNGPTLRPtSSIPANNPLVTQLLQGKDVPMEQILPKPLTKVEMKTVPL 722
Cdd:PHA03247  2910 QPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDP-AGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREA 2988

                   ..
gi 1607220055  723 TA 724
Cdd:PHA03247  2989 PA 2990
 
Name Accession Description Interval E-value
ASXH pfam13919
Asx homology domain; A conserved alpha helical domain with a characteriztic LXXLL motif. The ...
2-120 1.05e-39

Asx homology domain; A conserved alpha helical domain with a characteriztic LXXLL motif. The LXXLL motif is detected in diverse transcription factors, coactivators and corepressors and is implicated in mediating interactions between them. The ASXH domain is found in animals, fungi and plants and is predicted to play a role in mediating contact between transcription factors and chromatin-associated complexes. In Drosophila Asx and Human ASXL1, the ASXH domain is predicted to mediate interactions with the Calypso and BAP1 deubiquitinases (DUBs) which further belong to the UCHL5/UCH37 clade of DUBs.


Pssm-ID: 464041  Cd Length: 129  Bit Score: 143.20  E-value: 1.05e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1607220055    2 KRTKCADIDVETPDSILVNTNLRALINKHTFSVLPGDCQQRLLLLLPEVDRQVGPDGLMKLN--GSALNNEFFTSAAQGW 79
Cdd:pfam13919    8 KGKWEAEILLTSPKSPLVNADLRALLNKAAWDCLPPEEQQELLSLLPDVDHILDPDTDDSRPalPSLRNNEFFRHACARF 87
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1607220055   80 KERLSEGEFTPEMQVRIRQEIEKEK-KVEPWKEQFFESYYGQ 120
Cdd:pfam13919   88 QEDLAEGRFDPELRQAWKAEEKREAgKFDPWKEKEFEEFWGQ 129
PHD_3 pfam13922
PHD domain of transcriptional enhancer, Asx; This is the DNA-binding domain on the additional ...
1113-1173 1.64e-26

PHD domain of transcriptional enhancer, Asx; This is the DNA-binding domain on the additional sex combs-like 1 proteins. The Asx protein acts as an enhancer of trithorax and polycomb in displaying bidirectional homoeotic phenotypes in Drosophila, suggesting that it is required for maintenance of both activation and silencing of Hox genes. Asx is required for normal adult haematopoiesis and its function depends on its cellular context.


Pssm-ID: 316444  Cd Length: 68  Bit Score: 103.44  E-value: 1.64e-26
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1607220055 1113 MNPSSHGQTIPVQAFSEE-------NSIEGTPSKCYCRLKAMIMCKGCGAFCHDDCIGPSKLCVSCLV 1173
Cdd:pfam13922    1 QNPQQQQQHPLLQLAHQSgentppgNEATHTANKCACRLNAMVICQQCGAFCHDDCIGASKLCVSCVI 68
PHA03247 PHA03247
large tegument protein UL36; Provisional
484-724 9.54e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.32  E-value: 9.54e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1607220055  484 LPCGPETQPQSETKTTPSQAQPHSVSGAQLQQTPPVPPTPAVSGACTSVPSPAHIEKLDNEKLNPTRATATVASVSHPQG 563
Cdd:PHA03247  2750 TPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLP 2829
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1607220055  564 PSSCRQEKAPSPTGPALISGASPVHCAADGTVELKAGPSKNIP-NPSASSKTDASVPVAVTPSPLTSLLTTATLEKLPVP 642
Cdd:PHA03247  2830 PPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAaKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPP 2909
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1607220055  643 QVSATTAPAGSAPPSSTLPAASSLKTPGTSLNMNGPTLRPtSSIPANNPLVTQLLQGKDVPMEQILPKPLTKVEMKTVPL 722
Cdd:PHA03247  2910 QPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDP-AGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREA 2988

                   ..
gi 1607220055  723 TA 724
Cdd:PHA03247  2989 PA 2990
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
457-745 1.01e-03

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 43.02  E-value: 1.01e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1607220055  457 SDRVSETGKGPTLELAGTGSRGGTRELLPCGPETQPQSETKTTPSQAQPHSVSGAQLQQTPPVPPTPAVSGAcTSVPSPA 536
Cdd:pfam17823   83 STEVTAEHTPHGTDLSEPATREGAADGAASRALAAAASSSPSSAAQSLPAAIAALPSEAFSAPRAAACRANA-SAAPRAA 161
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1607220055  537 HIEKLDNEKLNPTRATATVASVSHPQGPSSCRQEKAPSPTGPALISGASPVHCAADGTVELKAGP-SKNIPNPSASSKTD 615
Cdd:pfam17823  162 IAAASAPHAASPAPRTAASSTTAASSTTAASSAPTTAASSAPATLTPARGISTAATATGHPAAGTaLAAVGNSSPAAGTV 241
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1607220055  616 ASVPVAVTPSPLTSLLTTatleklpVPQVSATTAPAGSAPPSSTLPAASSLKTPGTSLNMNGPTLRPTSSIPANNPLVTQ 695
Cdd:pfam17823  242 TAAVGTVTPAALATLAAA-------AGTVASAAGTINMGDPHARRLSPAKHMPSDTMARNPAAPMGAQAQGPIIQVSTDQ 314
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|
gi 1607220055  696 llqgkdvPMEQILPKPLTKVEMKTVPLTAKEERGMGALIATNTTENSTRE 745
Cdd:pfam17823  315 -------PVHNTAGEPTPSPSNTTLEPNTPKSVASTNLAVVTTTKAQAKE 357
 
Name Accession Description Interval E-value
ASXH pfam13919
Asx homology domain; A conserved alpha helical domain with a characteriztic LXXLL motif. The ...
2-120 1.05e-39

Asx homology domain; A conserved alpha helical domain with a characteriztic LXXLL motif. The LXXLL motif is detected in diverse transcription factors, coactivators and corepressors and is implicated in mediating interactions between them. The ASXH domain is found in animals, fungi and plants and is predicted to play a role in mediating contact between transcription factors and chromatin-associated complexes. In Drosophila Asx and Human ASXL1, the ASXH domain is predicted to mediate interactions with the Calypso and BAP1 deubiquitinases (DUBs) which further belong to the UCHL5/UCH37 clade of DUBs.


Pssm-ID: 464041  Cd Length: 129  Bit Score: 143.20  E-value: 1.05e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1607220055    2 KRTKCADIDVETPDSILVNTNLRALINKHTFSVLPGDCQQRLLLLLPEVDRQVGPDGLMKLN--GSALNNEFFTSAAQGW 79
Cdd:pfam13919    8 KGKWEAEILLTSPKSPLVNADLRALLNKAAWDCLPPEEQQELLSLLPDVDHILDPDTDDSRPalPSLRNNEFFRHACARF 87
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1607220055   80 KERLSEGEFTPEMQVRIRQEIEKEK-KVEPWKEQFFESYYGQ 120
Cdd:pfam13919   88 QEDLAEGRFDPELRQAWKAEEKREAgKFDPWKEKEFEEFWGQ 129
PHD_3 pfam13922
PHD domain of transcriptional enhancer, Asx; This is the DNA-binding domain on the additional ...
1113-1173 1.64e-26

PHD domain of transcriptional enhancer, Asx; This is the DNA-binding domain on the additional sex combs-like 1 proteins. The Asx protein acts as an enhancer of trithorax and polycomb in displaying bidirectional homoeotic phenotypes in Drosophila, suggesting that it is required for maintenance of both activation and silencing of Hox genes. Asx is required for normal adult haematopoiesis and its function depends on its cellular context.


Pssm-ID: 316444  Cd Length: 68  Bit Score: 103.44  E-value: 1.64e-26
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1607220055 1113 MNPSSHGQTIPVQAFSEE-------NSIEGTPSKCYCRLKAMIMCKGCGAFCHDDCIGPSKLCVSCLV 1173
Cdd:pfam13922    1 QNPQQQQQHPLLQLAHQSgentppgNEATHTANKCACRLNAMVICQQCGAFCHDDCIGASKLCVSCVI 68
PHA03247 PHA03247
large tegument protein UL36; Provisional
484-724 9.54e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.32  E-value: 9.54e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1607220055  484 LPCGPETQPQSETKTTPSQAQPHSVSGAQLQQTPPVPPTPAVSGACTSVPSPAHIEKLDNEKLNPTRATATVASVSHPQG 563
Cdd:PHA03247  2750 TPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLP 2829
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1607220055  564 PSSCRQEKAPSPTGPALISGASPVHCAADGTVELKAGPSKNIP-NPSASSKTDASVPVAVTPSPLTSLLTTATLEKLPVP 642
Cdd:PHA03247  2830 PPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAaKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPP 2909
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1607220055  643 QVSATTAPAGSAPPSSTLPAASSLKTPGTSLNMNGPTLRPtSSIPANNPLVTQLLQGKDVPMEQILPKPLTKVEMKTVPL 722
Cdd:PHA03247  2910 QPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDP-AGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREA 2988

                   ..
gi 1607220055  723 TA 724
Cdd:PHA03247  2989 PA 2990
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
457-745 1.01e-03

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 43.02  E-value: 1.01e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1607220055  457 SDRVSETGKGPTLELAGTGSRGGTRELLPCGPETQPQSETKTTPSQAQPHSVSGAQLQQTPPVPPTPAVSGAcTSVPSPA 536
Cdd:pfam17823   83 STEVTAEHTPHGTDLSEPATREGAADGAASRALAAAASSSPSSAAQSLPAAIAALPSEAFSAPRAAACRANA-SAAPRAA 161
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1607220055  537 HIEKLDNEKLNPTRATATVASVSHPQGPSSCRQEKAPSPTGPALISGASPVHCAADGTVELKAGP-SKNIPNPSASSKTD 615
Cdd:pfam17823  162 IAAASAPHAASPAPRTAASSTTAASSTTAASSAPTTAASSAPATLTPARGISTAATATGHPAAGTaLAAVGNSSPAAGTV 241
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1607220055  616 ASVPVAVTPSPLTSLLTTatleklpVPQVSATTAPAGSAPPSSTLPAASSLKTPGTSLNMNGPTLRPTSSIPANNPLVTQ 695
Cdd:pfam17823  242 TAAVGTVTPAALATLAAA-------AGTVASAAGTINMGDPHARRLSPAKHMPSDTMARNPAAPMGAQAQGPIIQVSTDQ 314
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|
gi 1607220055  696 llqgkdvPMEQILPKPLTKVEMKTVPLTAKEERGMGALIATNTTENSTRE 745
Cdd:pfam17823  315 -------PVHNTAGEPTPSPSNTTLEPNTPKSVASTNLAVVTTTKAQAKE 357
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
549-774 3.85e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 41.44  E-value: 3.85e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1607220055  549 TRATATVASVSHPQGPSSCRQEKAPSPTG---PALISG-ASPVHCAADGTVELKAGPS---KNIPNPSASSKTDASVPVA 621
Cdd:pfam05109  410 TNATTTTHKVIFSKAPESTTTSPTLNTTGfaaPNTTTGlPSSTHVPTNLTAPASTGPTvstADVTSPTPAGTTSGASPVT 489
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1607220055  622 VTPSPLTSLLTTATLEKL-PVPQVSATTAPAGSAPPSSTLPaasslkTPgtslNMNGPTL---RPTSSIPANNPLVTQLL 697
Cdd:pfam05109  490 PSPSPRDNGTESKAPDMTsPTSAVTTPTPNATSPTPAVTTP------TP----NATSPTLgktSPTSAVTTPTPNATSPT 559
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1607220055  698 QGKDVPMeqilPKPLTKVEMKTVPLTAkeergmgaliATNTTENSTREEVNERQSHP-ATQQQLGKTLQSKQLPQVPR 774
Cdd:pfam05109  560 PAVTTPT----PNATIPTLGKTSPTSA----------VTTPTPNATSPTVGETSPQAnTTNHTLGGTSSTPVVTSPPK 623
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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