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Conserved domains on  [gi|1758362504|ref|NP_001361584|]
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WAP four-disulfide core domain protein 2 isoform 2 precursor [Mus musculus]

Protein Classification

WAP domain-containing protein( domain architecture ID 10442829)

WAP domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WAP cd00199
whey acidic protein-type four-disulfide core domains. Members of the family include whey ...
 61-121 6.17e-10

whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of proteins containing 8 characteristically-spaced cysteine residuesforming disulphide bonds, have been termed '4-disulphide core' proteins. Protease inhibition occurs by insertion of the inhibitory loop into the active site pocket and interference with the catalytic residues of the protease.


:

Pssm-ID: 238120 [Multi-domain]  Cd Length: 60  Bit Score: 51.30  E-value: 6.17e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1758362504  61 CCQAGCSSVCSKPNEKQGTCPSVDIPKLGLCEDQCQVDSQCSGNMKCCRNGCGkMACTTPK 121
Cdd:cd00199     1 GNNMTKPGSCPRPVEKPGRCPMVNPPSLGIPPNRCSSDSDCPGDKKCCENGCG-KSCLTPV 60
WAP pfam00095
WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or ...
 32-73 1.52e-05

WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or elastase-specific inhibitors.


:

Pssm-ID: 459672 [Multi-domain]  Cd Length: 42  Bit Score: 39.33  E-value: 1.52e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1758362504  32 KPGECPQLEPITDCVLECTLDKDCADNRKCCQAGCSSVCSKP 73
Cdd:pfam00095   1 KPGCCPRLGARGCCRSCCSSDDDCPGRQKCCSNGCGSVCVPP 42
 
Name Accession Description Interval E-value
WAP cd00199
whey acidic protein-type four-disulfide core domains. Members of the family include whey ...
 61-121 6.17e-10

whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of proteins containing 8 characteristically-spaced cysteine residuesforming disulphide bonds, have been termed '4-disulphide core' proteins. Protease inhibition occurs by insertion of the inhibitory loop into the active site pocket and interference with the catalytic residues of the protease.


Pssm-ID: 238120 [Multi-domain]  Cd Length: 60  Bit Score: 51.30  E-value: 6.17e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1758362504  61 CCQAGCSSVCSKPNEKQGTCPSVDIPKLGLCEDQCQVDSQCSGNMKCCRNGCGkMACTTPK 121
Cdd:cd00199     1 GNNMTKPGSCPRPVEKPGRCPMVNPPSLGIPPNRCSSDSDCPGDKKCCENGCG-KSCLTPV 60
WAP pfam00095
WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or ...
 32-73 1.52e-05

WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or elastase-specific inhibitors.


Pssm-ID: 459672 [Multi-domain]  Cd Length: 42  Bit Score: 39.33  E-value: 1.52e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1758362504  32 KPGECPQLEPITDCVLECTLDKDCADNRKCCQAGCSSVCSKP 73
Cdd:pfam00095   1 KPGCCPRLGARGCCRSCCSSDDDCPGRQKCCSNGCGSVCVPP 42
WAP smart00217
Four-disulfide core domains;
76-121 2.53e-05

Four-disulfide core domains;


Pssm-ID: 197580 [Multi-domain]  Cd Length: 47  Bit Score: 38.89  E-value: 2.53e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1758362504   76 KQGTCPSVDI--PKLGLCEDQCQVDSQCSGNMKCCRNGCGkMACTTPK 121
Cdd:smart00217   1 KPGSCPWPTIasCPLGNPPNKCSSDSQCPGVKKCCFNGCG-KSCLTPV 47
WAP pfam00095
WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or ...
 76-120 5.05e-04

WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or elastase-specific inhibitors.


Pssm-ID: 459672 [Multi-domain]  Cd Length: 42  Bit Score: 35.48  E-value: 5.05e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1758362504  76 KQGTCPSVdiPKLGLCEDQCQVDSQCSGNMKCCRNGCGKMaCTTP 120
Cdd:pfam00095   1 KPGCCPRL--GARGCCRSCCSSDDDCPGRQKCCSNGCGSV-CVPP 42
 
Name Accession Description Interval E-value
WAP cd00199
whey acidic protein-type four-disulfide core domains. Members of the family include whey ...
 61-121 6.17e-10

whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of proteins containing 8 characteristically-spaced cysteine residuesforming disulphide bonds, have been termed '4-disulphide core' proteins. Protease inhibition occurs by insertion of the inhibitory loop into the active site pocket and interference with the catalytic residues of the protease.


Pssm-ID: 238120 [Multi-domain]  Cd Length: 60  Bit Score: 51.30  E-value: 6.17e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1758362504  61 CCQAGCSSVCSKPNEKQGTCPSVDIPKLGLCEDQCQVDSQCSGNMKCCRNGCGkMACTTPK 121
Cdd:cd00199     1 GNNMTKPGSCPRPVEKPGRCPMVNPPSLGIPPNRCSSDSDCPGDKKCCENGCG-KSCLTPV 60
WAP pfam00095
WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or ...
 32-73 1.52e-05

WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or elastase-specific inhibitors.


Pssm-ID: 459672 [Multi-domain]  Cd Length: 42  Bit Score: 39.33  E-value: 1.52e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1758362504  32 KPGECPQLEPITDCVLECTLDKDCADNRKCCQAGCSSVCSKP 73
Cdd:pfam00095   1 KPGCCPRLGARGCCRSCCSSDDDCPGRQKCCSNGCGSVCVPP 42
WAP smart00217
Four-disulfide core domains;
76-121 2.53e-05

Four-disulfide core domains;


Pssm-ID: 197580 [Multi-domain]  Cd Length: 47  Bit Score: 38.89  E-value: 2.53e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1758362504   76 KQGTCPSVDI--PKLGLCEDQCQVDSQCSGNMKCCRNGCGkMACTTPK 121
Cdd:smart00217   1 KPGSCPWPTIasCPLGNPPNKCSSDSQCPGVKKCCFNGCG-KSCLTPV 47
WAP pfam00095
WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or ...
 76-120 5.05e-04

WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or elastase-specific inhibitors.


Pssm-ID: 459672 [Multi-domain]  Cd Length: 42  Bit Score: 35.48  E-value: 5.05e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1758362504  76 KQGTCPSVdiPKLGLCEDQCQVDSQCSGNMKCCRNGCGKMaCTTP 120
Cdd:pfam00095   1 KPGCCPRL--GARGCCRSCCSSDDDCPGRQKCCSNGCGSV-CVPP 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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