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Conserved domains on  [gi|1771661244|ref|NP_001362605|]
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abl interactor 2 isoform p [Homo sapiens]

Protein Classification

Abi_HHR domain-containing protein( domain architecture ID 10544819)

Abi_HHR domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Abi_HHR pfam07815
Abl-interactor HHR; The region featured in this family is found towards the N-terminus of a ...
 93-156 2.18e-38

Abl-interactor HHR; The region featured in this family is found towards the N-terminus of a number of adaptor proteins that interact with Abl-family tyrosine kinases. More specifically, it is termed the homeo-domain homologous region (HHR), as it is similar to the DNA-binding region of homeo-domain proteins. Other homeo-domain proteins have been implicated in specifying positional information during embryonic development, and in the regulation of the expression of cell-type specific genes. The Abl-interactor proteins are thought to coordinate the cytoplasmic and nuclear functions of the Abl-family kinases, and seem to be involved in cytoskeletal reorganization, but their precise role remains unclear.


:

Pssm-ID: 462279  Cd Length: 64  Bit Score: 134.75  E-value: 2.18e-38
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1771661244  93 ISQTVDIHKEKVARREIGILTTNKNTSRTHKIIAPANLERPVRYIRKPIDYTILDDIGHGVKWL 156
Cdd:pfam07815   1 ISQTVDIHKEKVARREIGVLTTNKRLPRQQKIIAPANPEPPIKYSRKPIDYSCLDDIGHGVKDS 64
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 270-399 3.46e-09

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 59.95  E-value: 3.46e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1771661244  270 PIAVPTPSPPSVFPAPAGSA--GTPPLPATSASAPAPLVPATVPSSTAPDAAAGGAQTLADGFTSPTPPVVSSTPPTGHP 347
Cdd:PHA03247  2736 PAAPAPPAVPAGPATPGGPArpARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPA 2815

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1771661244  348 VQFYSMNRPASRHTPPT--IGGSLPYRRPPSITSQTSLQNQMNGGPFYSQNPAQ 399
Cdd:PHA03247  2816 AALPPAASPAGPLPPPTsaQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSR 2869
 
Name Accession Description Interval E-value
Abi_HHR pfam07815
Abl-interactor HHR; The region featured in this family is found towards the N-terminus of a ...
 93-156 2.18e-38

Abl-interactor HHR; The region featured in this family is found towards the N-terminus of a number of adaptor proteins that interact with Abl-family tyrosine kinases. More specifically, it is termed the homeo-domain homologous region (HHR), as it is similar to the DNA-binding region of homeo-domain proteins. Other homeo-domain proteins have been implicated in specifying positional information during embryonic development, and in the regulation of the expression of cell-type specific genes. The Abl-interactor proteins are thought to coordinate the cytoplasmic and nuclear functions of the Abl-family kinases, and seem to be involved in cytoskeletal reorganization, but their precise role remains unclear.


Pssm-ID: 462279  Cd Length: 64  Bit Score: 134.75  E-value: 2.18e-38
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1771661244  93 ISQTVDIHKEKVARREIGILTTNKNTSRTHKIIAPANLERPVRYIRKPIDYTILDDIGHGVKWL 156
Cdd:pfam07815   1 ISQTVDIHKEKVARREIGVLTTNKRLPRQQKIIAPANPEPPIKYSRKPIDYSCLDDIGHGVKDS 64
PHA03247 PHA03247
large tegument protein UL36; Provisional
 270-399 3.46e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 59.95  E-value: 3.46e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1771661244  270 PIAVPTPSPPSVFPAPAGSA--GTPPLPATSASAPAPLVPATVPSSTAPDAAAGGAQTLADGFTSPTPPVVSSTPPTGHP 347
Cdd:PHA03247  2736 PAAPAPPAVPAGPATPGGPArpARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPA 2815

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1771661244  348 VQFYSMNRPASRHTPPT--IGGSLPYRRPPSITSQTSLQNQMNGGPFYSQNPAQ 399
Cdd:PHA03247  2816 AALPPAASPAGPLPPPTsaQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSR 2869
DUF4813 pfam16072
Domain of unknown function (DUF4813); This family of proteins is functionally uncharacterized. ...
 268-374 4.82e-07

Domain of unknown function (DUF4813); This family of proteins is functionally uncharacterized. This family of proteins is found in eukaryotes. Proteins in this family are typically between 345 and 672 amino acids in length.


Pssm-ID: 435117 [Multi-domain]  Cd Length: 288  Bit Score: 51.68  E-value: 4.82e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1771661244 268 GVPIAVPTPSPPSVFPAPAgsagTPPLPATSASAP-APLVPATvPSSTAPDAAAGGAQTLADGFTSPTppvvSSTPPTGH 346
Cdd:pfam16072 169 AAPAAPAYPVAPAAYPAQA----PAAAPAPAPGAPqTPLAPLN-PVAAAPAAAAGAAAAPVVAAAAPA----AAAPPPPA 239

                          90       100       110
                  ....*....|....*....|....*....|
gi 1771661244 347 PvqfysmNRPASRHTPPTIGG--SLPYRRP 374
Cdd:pfam16072 240 P------AAPPADAAPPAPGGiiCVPVRVP 263
rad23 TIGR00601
UV excision repair protein Rad23; All proteins in this family for which functions are known ...
 272-345 3.79e-03

UV excision repair protein Rad23; All proteins in this family for which functions are known are components of a multiprotein complex used for targeting nucleotide excision repair to specific parts of the genome. In humans, Rad23 complexes with the XPC protein. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273167 [Multi-domain]  Cd Length: 378  Bit Score: 39.88  E-value: 3.79e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1771661244 272 AVPTPSPPSvfpAPAGSAGTPPLPATSASAPAPlvPATVPSSTAPDAAAGGAQTLADGFTSPTPPVVSSTPPTG 345
Cdd:TIGR00601  85 APPAATPTS---APTPTPSPPASPASGMSAAPA--SAVEEKSPSEESATATAPESPSTSVPSSGSDAASTLVVG 153
KLF14_N cd21576
N-terminal domain of Kruppel-like factor 14; Kruppel-like factor 14 (KLF14; also known as ...
 270-374 6.34e-03

N-terminal domain of Kruppel-like factor 14; Kruppel-like factor 14 (KLF14; also known as Krueppel-like factor 14 or basic transcription element-binding protein 5/BTEB5) is a protein that in humans is encoded by the KLF14 gene. KLF14 regulates the transcription of various genes, including TGFbetaRII (the type II receptor for TGFbeta). KLF14 is expressed in many tissues, lacks introns, and is subject to parent-specific expression. It also appears to be a master regulator of gene expression in adipose tissue. KLF14 is associated with coronary artery disease, hypercholesterolemia, and type 2 diabetes. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved alpha-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF14 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF14.


Pssm-ID: 409238 [Multi-domain]  Cd Length: 195  Bit Score: 37.88  E-value: 6.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1771661244 270 PIAVPTPSPPSVFPAP---AGSA----------------GTPPLPATSASAPAplvPATVPSSTAPDAAAGGAQTLADGF 330
Cdd:cd21576    65 LLQVPAPSPGAGGAAPhllAASVladlrggagegsredsGEAPRASSGSSDPA---RGSSPTLGSEPAPASGEDAVSGPE 141

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1771661244 331 TSPTPPVVSSTPPT-GHPVQFYSMNRPASRHTPPTIGGSLPYRRP 374
Cdd:cd21576   142 SSFGAPAIPSAPAApGAPAVSGEVPGGAPGAGPAPAAGPAPRRRP 186
 
Name Accession Description Interval E-value
Abi_HHR pfam07815
Abl-interactor HHR; The region featured in this family is found towards the N-terminus of a ...
 93-156 2.18e-38

Abl-interactor HHR; The region featured in this family is found towards the N-terminus of a number of adaptor proteins that interact with Abl-family tyrosine kinases. More specifically, it is termed the homeo-domain homologous region (HHR), as it is similar to the DNA-binding region of homeo-domain proteins. Other homeo-domain proteins have been implicated in specifying positional information during embryonic development, and in the regulation of the expression of cell-type specific genes. The Abl-interactor proteins are thought to coordinate the cytoplasmic and nuclear functions of the Abl-family kinases, and seem to be involved in cytoskeletal reorganization, but their precise role remains unclear.


Pssm-ID: 462279  Cd Length: 64  Bit Score: 134.75  E-value: 2.18e-38
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1771661244  93 ISQTVDIHKEKVARREIGILTTNKNTSRTHKIIAPANLERPVRYIRKPIDYTILDDIGHGVKWL 156
Cdd:pfam07815   1 ISQTVDIHKEKVARREIGVLTTNKRLPRQQKIIAPANPEPPIKYSRKPIDYSCLDDIGHGVKDS 64
PHA03247 PHA03247
large tegument protein UL36; Provisional
 270-399 3.46e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 59.95  E-value: 3.46e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1771661244  270 PIAVPTPSPPSVFPAPAGSA--GTPPLPATSASAPAPLVPATVPSSTAPDAAAGGAQTLADGFTSPTPPVVSSTPPTGHP 347
Cdd:PHA03247  2736 PAAPAPPAVPAGPATPGGPArpARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPA 2815

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1771661244  348 VQFYSMNRPASRHTPPT--IGGSLPYRRPPSITSQTSLQNQMNGGPFYSQNPAQ 399
Cdd:PHA03247  2816 AALPPAASPAGPLPPPTsaQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSR 2869
DUF4813 pfam16072
Domain of unknown function (DUF4813); This family of proteins is functionally uncharacterized. ...
 268-374 4.82e-07

Domain of unknown function (DUF4813); This family of proteins is functionally uncharacterized. This family of proteins is found in eukaryotes. Proteins in this family are typically between 345 and 672 amino acids in length.


Pssm-ID: 435117 [Multi-domain]  Cd Length: 288  Bit Score: 51.68  E-value: 4.82e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1771661244 268 GVPIAVPTPSPPSVFPAPAgsagTPPLPATSASAP-APLVPATvPSSTAPDAAAGGAQTLADGFTSPTppvvSSTPPTGH 346
Cdd:pfam16072 169 AAPAAPAYPVAPAAYPAQA----PAAAPAPAPGAPqTPLAPLN-PVAAAPAAAAGAAAAPVVAAAAPA----AAAPPPPA 239

                          90       100       110
                  ....*....|....*....|....*....|
gi 1771661244 347 PvqfysmNRPASRHTPPTIGG--SLPYRRP 374
Cdd:pfam16072 240 P------AAPPADAAPPAPGGiiCVPVRVP 263
PHA03247 PHA03247
large tegument protein UL36; Provisional
 188-398 9.02e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.25  E-value: 9.02e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1771661244  188 GKGTLGRHSPYRTLEPVRPPVVPNDYVP-SPTRNMAPSQQS-PVRTASvnQRNRTYSSSGSSGGSHPSSRSSSRENSGSG 265
Cdd:PHA03247  2724 GPAAARQASPALPAAPAPPAVPAGPATPgGPARPARPPTTAgPPAPAP--PAAPAAGPPRRLTRPAVASLSESRESLPSP 2801

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1771661244  266 SVGVPIAVPTPSPPSVFPAPAGSAGTPPLPATSASAPAPLVPATVPSSTAPDAAAGGAQTLADGFTSPTPPVVSSTPPtg 345
Cdd:PHA03247  2802 WDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPA-- 2879

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1771661244  346 HPvQFYSMNRPA-SRHTPPTIGGSLPYRRPPSITSQTSLQNQMNGGPFYSQNPA 398
Cdd:PHA03247  2880 RP-PVRRLARPAvSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPP 2932
PHA03247 PHA03247
large tegument protein UL36; Provisional
 194-376 7.57e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.17  E-value: 7.57e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1771661244  194 RHSPYRTLEPV-RPPVVPNDYVPSPTRNMAPSQQSPVRTASVNQRNRTYSSSGSSGGSHPSSRSSSRENSGSGSvgvPIA 272
Cdd:PHA03247  2605 RGDPRGPAPPSpLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASS---PPQ 2681

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1771661244  273 VPTP--SPPSVFPApAGSAGTPPLPATSASAPAPLVPATvPSSTAPDAAAGGAQTLAdgfTSPTPPVVSSTPPTghPVqf 350
Cdd:PHA03247  2682 RPRRraARPTVGSL-TSLADPPPPPPTPEPAPHALVSAT-PLPPGPAAARQASPALP---AAPAPPAVPAGPAT--PG-- 2752

                          170       180
                   ....*....|....*....|....*.
gi 1771661244  351 ySMNRPASRHTPPTIGGSLPYRRPPS 376
Cdd:PHA03247  2753 -GPARPARPPTTAGPPAPAPPAAPAA 2777
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 268-370 1.30e-05

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 47.99  E-value: 1.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1771661244 268 GVPIAVPTPS----PPSVFPAPAGSAGTPPLPATSASAPAPLVPATVPSSTAPDAAAGGAQTLADGFTSPTPPVVSSTPp 343
Cdd:pfam05109 447 GLPSSTHVPTnltaPASTGPTVSTADVTSPTPAGTTSGASPVTPSPSPRDNGTESKAPDMTSPTSAVTTPTPNATSPTP- 525

                          90       100
                  ....*....|....*....|....*..
gi 1771661244 344 tghpvqfySMNRPASRHTPPTIGGSLP 370
Cdd:pfam05109 526 --------AVTTPTPNATSPTLGKTSP 544
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
267-373 1.78e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 47.54  E-value: 1.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1771661244 267 VGVPIAVPTPSPPSVFPAPAGSAGTPPLPATSASAPAPLVPATVPSSTAPDAAAGGAQTlADGFTSPTPPVVSSTPPTGH 346
Cdd:PRK07003  445 GDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAAT-PAAVPDARAPAAASREDAPA 523

                          90       100
                  ....*....|....*....|....*..
gi 1771661244 347 PVQfysmnRPASRHTPPTIGGSLPYRR 373
Cdd:PRK07003  524 AAA-----PPAPEARPPTPAAAAPAAR 545
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 268-425 1.82e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 47.40  E-value: 1.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1771661244 268 GVPIAVPTPSPPSVFPAPAGSAGTPPLPATSASAPAPLVPATVPSSTAPDAAAGGAQTLADGFTSPTPPV----VSSTPP 343
Cdd:PRK14951  369 AAEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPaaapAAVALA 448

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1771661244 344 TGHPVQFYSMNRPASRHTPPTIGGSLPYRRPPSITSQTSLQnQMNGGPFYSQNPAQLQERQYILAHRRSCQMKSYKVRKE 423
Cdd:PRK14951  449 PAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAAARLT-PTEEGDVWHATVQQLAAAEAITALARELALQSELVARD 527


                  ..
gi 1771661244 424 ND 425
Cdd:PRK14951  528 GD 529
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 195-379 5.22e-05

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 46.06  E-value: 5.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1771661244 195 HSPYRTLEPVRP-PVVPNDYVPSPTRNMAPSQQSPVrTASVNQRNRTYSSSGSSGGSHPSSRSSSRENSGSGSVGVPIAV 273
Cdd:pfam05109 453 HVPTNLTAPASTgPTVSTADVTSPTPAGTTSGASPV-TPSPSPRDNGTESKAPDMTSPTSAVTTPTPNATSPTPAVTTPT 531

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1771661244 274 PTPSPPSVFPAPAGSAGTPPLPatSASAPAPLVPATVPSSTAPdaaaggaqTLadGFTSPTPPVVSSTPPTGHPVqfYSM 353
Cdd:pfam05109 532 PNATSPTLGKTSPTSAVTTPTP--NATSPTPAVTTPTPNATIP--------TL--GKTSPTSAVTTPTPNATSPT--VGE 597

                         170       180
                  ....*....|....*....|....*.
gi 1771661244 354 NRPASRHTPPTIGGSlpyRRPPSITS 379
Cdd:pfam05109 598 TSPQANTTNHTLGGT---SSTPVVTS 620
PHA02682 PHA02682
ORF080 virion core protein; Provisional
 210-387 7.34e-05

ORF080 virion core protein; Provisional


Pssm-ID: 177464 [Multi-domain]  Cd Length: 280  Bit Score: 44.85  E-value: 7.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1771661244 210 PNDYVPSPTRNMAPSQQ-SPVRTASVNQRNRTYSSSGSSGGSHPSSRSSSRensgsgsvgvPIAvptPSPPSVFPAPAGS 288
Cdd:PHA02682   30 PQATIPAPAAPCPPDADvDPLDKYSVKEAGRYYQSRLKANSACMQRPSGQS----------PLA---PSPACAAPAPACP 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1771661244 289 AGTPPLPATSASAPAPlVPAtVPSSTAPdaaaggaqtladgfTSPtPPVVSSTPPTGHPVqfysmNRPASRHTPPtiGGS 368
Cdd:PHA02682   97 ACAPAAPAPAVTCPAP-APA-CPPATAP--------------TCP-PPAVCPAPARPAPA-----CPPSTRQCPP--APP 152

                         170
                  ....*....|....*....
gi 1771661244 369 LPYRRPPSITSQTSLQNQM 387
Cdd:PHA02682  153 LPTPKPAPAAKPIFLHNQL 171
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
196-370 1.54e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 44.48  E-value: 1.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1771661244 196 SPYRTLEPVRPPVVPNDYVPSPTRNMAPSQQSPVRTASVNQRNRTYSSSGSSGGSHPSSRSSSRENSGSGSVGV--PIAV 273
Cdd:PRK12323  396 APAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPrpVAAA 475

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1771661244 274 PTPSPPSVFPAPAGSA---GTPP---LPATSAS-APAPLVPATVPSSTAPDAAAGGAQTLADGFTSPTPPVVSSTPPTGH 346
Cdd:PRK12323  476 AAAAPARAAPAAAPAPaddDPPPweeLPPEFASpAPAQPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAA 555

                         170       180
                  ....*....|....*....|....*..
gi 1771661244 347 PVQFYSMNRP---ASRHTPPTIGGSLP 370
Cdd:PRK12323  556 ATEPVVAPRPpraSASGLPDMFDGDWP 582
DUF3729 pfam12526
Protein of unknown function (DUF3729); This family of proteins is found in viruses. Proteins ...
 276-349 2.31e-04

Protein of unknown function (DUF3729); This family of proteins is found in viruses. Proteins in this family are typically between 145 and 1707 amino acids in length. The family is found in association with pfam01443, pfam01661, pfam05417, pfam01660, pfam00978. There is a single completely conserved residue L that may be functionally important.


Pssm-ID: 372164 [Multi-domain]  Cd Length: 115  Bit Score: 40.83  E-value: 2.31e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1771661244 276 PSPP-SVFPAPAGSAGTPPLPATSASAPAP--LVPATVPSSTAPDAAaggaqtLADGFTSPTPPVVSSTPPtgHPVQ 349
Cdd:pfam12526  29 FSPPeSAHPDPPPPVGDPRPPVVDTPPPVSavWVLPPPSEPAAPEPD------LVPPVTGPAGPPSPLAPP--APAQ 97
PRK11855 PRK11855
dihydrolipoamide acetyltransferase; Reviewed
 267-327 3.00e-04

dihydrolipoamide acetyltransferase; Reviewed


Pssm-ID: 237000 [Multi-domain]  Cd Length: 547  Bit Score: 43.27  E-value: 3.00e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1771661244 267 VGVPIAVPTPSPPSVFPAPAGSAGTPPLPATSASAPAPLVPATVPSSTAPDAAAGGAQTLA 327
Cdd:PRK11855  185 VGSLLVVIEVAAAAPAAAAAPAAAAPAAAAAAAPAPAPAAAAAPAAAAPAAAAAPGKAPHA 245
PRK06549 PRK06549
acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
 267-316 3.09e-04

acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated


Pssm-ID: 235826 [Multi-domain]  Cd Length: 130  Bit Score: 40.95  E-value: 3.09e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1771661244 267 VGVPIAVPTPSPPSVFPAPAGSAgtpPLPATSASAPAPLVPATVPSSTAP 316
Cdd:PRK06549   21 IGAPAQAAAPAQPASTPVPVPTE---ASPQVEAQAPQPAAAAGADAMPSP 67
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 270-375 3.10e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.44  E-value: 3.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1771661244 270 PIAVPTPSPPSVFPAPAGSAGTPPLPATSASAPAPlvPATVPSSTAPDAAAGGAQTLADGFTSPTPPVVSSTPPTGHPVQ 349
Cdd:PRK07764  678 PAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAG--QADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAP 755

                          90       100
                  ....*....|....*....|....*.
gi 1771661244 350 FYSMNRPASRHTPPTIGGSLPYRRPP 375
Cdd:PRK07764  756 AQPPPPPAPAPAAAPAAAPPPSPPSE 781
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 274-376 3.35e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.44  E-value: 3.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1771661244 274 PTPSPPSVFPAPAGSAGTPPLPATSASAPAPLVPAT------VPSSTAPDAAAGGAQTLADGFTSPTPPVVSSTPPTGHP 347
Cdd:PRK07764  615 PAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPehhpkhVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPA 694

                          90       100
                  ....*....|....*....|....*....
gi 1771661244 348 VQFYSMNRPASRHTPPTIGGSLPYRRPPS 376
Cdd:PRK07764  695 GAAPAQPAPAPAATPPAGQADDPAAQPPQ 723
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 272-375 3.96e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 43.24  E-value: 3.96e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1771661244  272 AVPTPSPPSVFPAPAGSAGTPPLPATSASAPAPLVPATVPSSTAPDA----AAGGAQTLADGFTSPTPPVVSSTPPTGHP 347
Cdd:PHA03307   124 ASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRqaalPLSSPEETARAPSSPPAEPPPSTPPAAAS 203

                           90       100
                   ....*....|....*....|....*...
gi 1771661244  348 vqfysmNRPASRHTPPTIGGSLPYRRPP 375
Cdd:PHA03307   204 ------PRPPRRSSPISASASSPAPAPG 225
FAP pfam07174
Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment ...
 273-345 7.64e-04

Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment proteins (FAP). Family members are rich in alanine and proline, are approximately 300 long, and seem to be restricted to mycobacteria. These proteins contain a fibronectin-binding motif that allows mycobacteria to bind to fibronectin in the extracellular matrix.


Pssm-ID: 429334  Cd Length: 301  Bit Score: 41.84  E-value: 7.64e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1771661244 273 VPTPSPPSVFPAPAGSAGTPPLPATSASAPAPLVPATVPSSTAPDAAAGGAQTLADGFTSPTPPVVSSTPPTG 345
Cdd:pfam07174  42 EPAPPPPSTATAPPAPPPPPPAPAAPAPPPPPAAPNAPNAPPPPADPNAPPPPPADPNAPPPPAVDPNAPEPG 114
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
268-402 8.34e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 42.14  E-value: 8.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1771661244 268 GVPIAVPTPSPPSVFPAPAgsAGTPPLPATSASAPAPLVPATVPSSTAPDAAAGGAQTLAdgftsPTPPVVSSTPPTGHP 347
Cdd:PRK07003  366 GAPGGGVPARVAGAVPAPG--ARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRA-----EAPPAAPAPPATADR 438

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1771661244 348 VQfysmnRPASRHTPPTIGGSLPYR---RPPSITSQTSLQNQMNGGPFYSQNPAQLQE 402
Cdd:PRK07003  439 GD-----DAADGDAPVPAKANARASadsRCDERDAQPPADSGSASAPASDAPPDAAFE 491
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 268-376 8.84e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.28  E-value: 8.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1771661244 268 GVPIAVPTPSPPsvfPAPAGSAGTPPLPATSASAPAPLVPATVPSSTAPDAAAGGAQTladgftsPTPPVVSSTPPTGHP 347
Cdd:PRK07764  384 RLGVAGGAGAPA---AAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPA-------PAPPSPAGNAPAGGA 453

                          90       100
                  ....*....|....*....|....*....
gi 1771661244 348 VQFYSMNRPASRHTPPTIGGSLPYRRPPS 376
Cdd:PRK07764  454 PSPPPAAAPSAQPAPAPAAAPEPTAAPAP 482
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 203-375 9.72e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.90  E-value: 9.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1771661244 203 PVRPPVVPNDYVPSPTRNMAPSQQSPVRTASVNQRNRTYSSSGSSGGSHPSSRSSSRENSGSGSVGVPIAVPTPSPPSVF 282
Cdd:PRK07764  601 PAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAA 680

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1771661244 283 PAPAGSAGTPPLPAT-SASAPAPLVPATVPSSTAPDAAAGGAQTLADGFTSPT-PPVVSSTPPTGHPVQFYSMNRPASRH 360
Cdd:PRK07764  681 PPPAPAPAAPAAPAGaAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPaADDPVPLPPEPDDPPDPAGAPAQPPP 760

                         170
                  ....*....|....*
gi 1771661244 361 TPPTIGGSLPYRRPP 375
Cdd:PRK07764  761 PPAPAPAAAPAAAPP 775
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
269-379 1.17e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.79  E-value: 1.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1771661244 269 VPIAVPTPSPPSVFPAPAGSAGTPPLPATSASAPAPLVPAtvpssTAPDAAAGGAQTLADGFTSPTPPVVSSTPPTGHPv 348
Cdd:PRK12323  390 AAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPA-----PEALAAARQASARGPGGAPAPAPAPAAAPAAAAR- 463

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1771661244 349 qfysmNRPASRHTPPTIGGSLPYRRPPSITS 379
Cdd:PRK12323  464 -----PAAAGPRPVAAAAAAAPARAAPAAAP 489
PLN02983 PLN02983
biotin carboxyl carrier protein of acetyl-CoA carboxylase
 271-335 1.59e-03

biotin carboxyl carrier protein of acetyl-CoA carboxylase


Pssm-ID: 215533 [Multi-domain]  Cd Length: 274  Bit Score: 40.59  E-value: 1.59e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1771661244 271 IAVPTPSPPSVFPAPAGSAGTPPLPATSASAPAPLVP--ATVPSSTAPDAAAGGAQTLadgFTSPTP 335
Cdd:PLN02983  151 VMMQPPPPHAMPPASPPAAQPAPSAPASSPPPTPASPppAKAPKSSHPPLKSPMAGTF---YRSPAP 214
PHA03247 PHA03247
large tegument protein UL36; Provisional
 274-375 1.72e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 1.72e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1771661244  274 PTPSPPSVFPAPAGSAGTPPLPATSASAPAPLVPATVPSstAPDAAAGGAQTLADGFTSPTPPVVSSTPPTGHPVQFYSM 353
Cdd:PHA03247  2552 PPPLPPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPD--APPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPP 2629

                           90       100
                   ....*....|....*....|..
gi 1771661244  354 NrPASRHTPPTIGGSLPYRRPP 375
Cdd:PHA03247  2630 S-PSPAANEPDPHPPPTVPPPE 2650
PHA03247 PHA03247
large tegument protein UL36; Provisional
 270-382 2.12e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 2.12e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1771661244  270 PIAVPTPSPPSVFPAP------AGSAGTPPlpatsaSAPAPLVPATVPSSTAPDAAAGGAQTLAdgftsptppVVSstpP 343
Cdd:PHA03247   278 PPPPPEAAAPNGAAAPpdgvwgAALAGAPL------ALPAPPDPPPPAPAGDAEEEDDEDGAME---------VVS---P 339

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1771661244  344 TGHPVQFYSMNRPASRH---TPP------TIGGSLPYRRPPSITSQTS 382
Cdd:PHA03247   340 LPRPRQHYPLGFPKRRRptwTPPssledlSAGRHHPKRASLPTRKRRS 387
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 272-414 2.15e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.91  E-value: 2.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1771661244 272 AVPTPSPPSVFPAPAGSAGTPPLPATSASAPAPLV--PATVPSSTAPDAA--AGGAQTLADGFTSPTPPVVSSTPPTGHP 347
Cdd:pfam03154 180 AASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATsqPPNQTQSTAAPHTliQQTPTLHPQRLPSPHPPLQPMTQPPPPS 259

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1771661244 348 VQFYSMNRPASRHTP-PTIGGSL-------PYRRPPS---ITSQTSlQNQMNGGPfYSQNPAQLQERQYILAHRRSCQ 414
Cdd:pfam03154 260 QVSPQPLPQPSLHGQmPPMPHSLqtgpshmQHPVPPQpfpLTPQSS-QSQVPPGP-SPAAPGQSQQRIHTPPSQSQLQ 335
FAP pfam07174
Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment ...
 270-349 2.50e-03

Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment proteins (FAP). Family members are rich in alanine and proline, are approximately 300 long, and seem to be restricted to mycobacteria. These proteins contain a fibronectin-binding motif that allows mycobacteria to bind to fibronectin in the extracellular matrix.


Pssm-ID: 429334  Cd Length: 301  Bit Score: 39.91  E-value: 2.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1771661244 270 PIAVPTPSPPSVFPAPAGSAGTPPLPATSASAPAPlvPATVPSSTAPDAAAGGAqtladgftsPTPPVVSstPPTGHPVQ 349
Cdd:pfam07174  49 STATAPPAPPPPPPAPAAPAPPPPPAAPNAPNAPP--PPADPNAPPPPPADPNA---------PPPPAVD--PNAPEPGR 115
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 267-342 2.52e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.74  E-value: 2.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1771661244 267 VGVPIAVPTPSPPSV-----FPAPAGSAGTPPLPATSASAPAPLvPATVPSSTAPDAAAGGAQTLADGFTSPTPPVVSST 341
Cdd:PRK07764  387 VAGGAGAPAAAAPSAaaaapAAAPAPAAAAPAAAAAPAPAAAPQ-PAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQ 465


                  .
gi 1771661244 342 P 342
Cdd:PRK07764  466 P 466
PHA03247 PHA03247
large tegument protein UL36; Provisional
 270-383 2.56e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 2.56e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1771661244  270 PIAVPTPSPPSVFPAPAGSAGTPPLPATSASAPAPLVPAtvPSSTAPDAAAGGAQTLADGFTSPTPPVVSSTPPTGHPVQ 349
Cdd:PHA03247  2589 PDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPP--PPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRR 2666

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1771661244  350 FYSMNRPASRHTPPTigGSLPYRRPPSITSQTSL 383
Cdd:PHA03247  2667 ARRLGRAAQASSPPQ--RPRRRAARPTVGSLTSL 2698
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 274-394 3.13e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 40.28  E-value: 3.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1771661244 274 PTPSPPSVFPAPAG-SAGTPPLPATSASAPA---PLVPATVPSSTAPDAAAGGAQTLADGFTSPTPPVVSSTPPTGHPVQ 349
Cdd:pfam05109 712 PGNSSTSTKPGEVNvTKGTPPKNATSPQAPSgqkTAVPTVTSTGGKANSTTGGKHTTGHGARTSTEPTTDYGGDSTTPRT 791

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1771661244 350 FYSmnrpASRHTPPTIGGSL----PYRRPPSITSQTSLQNQMNGGPFYS 394
Cdd:pfam05109 792 RYN----ATTYLPPSTSSKLrprwTFTSPPVTTAQATVPVPPTSQPRFS 836
rad23 TIGR00601
UV excision repair protein Rad23; All proteins in this family for which functions are known ...
 272-345 3.79e-03

UV excision repair protein Rad23; All proteins in this family for which functions are known are components of a multiprotein complex used for targeting nucleotide excision repair to specific parts of the genome. In humans, Rad23 complexes with the XPC protein. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273167 [Multi-domain]  Cd Length: 378  Bit Score: 39.88  E-value: 3.79e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1771661244 272 AVPTPSPPSvfpAPAGSAGTPPLPATSASAPAPlvPATVPSSTAPDAAAGGAQTLADGFTSPTPPVVSSTPPTG 345
Cdd:TIGR00601  85 APPAATPTS---APTPTPSPPASPASGMSAAPA--SAVEEKSPSEESATATAPESPSTSVPSSGSDAASTLVVG 153
PHA03247 PHA03247
large tegument protein UL36; Provisional
 276-389 5.07e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.92  E-value: 5.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1771661244  276 PSPPsvfPAPAGSAGTPPLPATSASAPAPLVPATVPSS-TAPDAAAGGAQTLADGFTSPTPPVVSSTPPTGHP------V 348
Cdd:PHA03247   255 PAPP---PVVGEGADRAPETARGATGPPPPPEAAAPNGaAAPPDGVWGAALAGAPLALPAPPDPPPPAPAGDAeeeddeD 331

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1771661244  349 QFYSMNRPASRHTPPTIGGsLPYRRPPSITSQTSLQNQMNG 389
Cdd:PHA03247   332 GAMEVVSPLPRPRQHYPLG-FPKRRRPTWTPPSSLEDLSAG 371
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 270-349 5.29e-03

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 39.87  E-value: 5.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1771661244  270 PIAVPTPSPPSVFPAPAGSAGTPPLPATSASAPAPLVPATVPSSTAPDAAAGGAQTLADgftSPTPPVVSSTPPTGHPVQ 349
Cdd:PRK12270    38 PGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAAP---AAPPAAAAAAAPAAAAVE 114
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 278-363 5.39e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 39.31  E-value: 5.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1771661244 278 PPSVFPAPAGSAGTPPLPAtSASAPAPLVPATVPSSTAPDAAAGGAQTLADGFTSPTPPVVSSTPPTGHPVQFySMNRPA 357
Cdd:PRK14951  366 PAAAAEAAAPAEKKTPARP-EAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAA-PAAAPA 443


                  ....*.
gi 1771661244 358 SRHTPP 363
Cdd:PRK14951  444 AVALAP 449
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 270-398 6.26e-03

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 39.14  E-value: 6.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1771661244 270 PIAVPTPSPPSVFPAPAGSAGTPPLPATSASAPAPLVPATVPSSTAPDAAAGGAQTLA-----DGFTSPTPPvvSSTPPT 344
Cdd:PLN03209  382 PPTSPIPTPPSSSPASSKSVDAVAKPAEPDVVPSPGSASNVPEVEPAQVEAKKTRPLSpyaryEDLKPPTSP--SPTAPT 459

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1771661244 345 G-HPVQFYSMNRPASRHT-PPTIGGSLPYRRPPSITSQTSLQNQMNGGPFYSQNPA 398
Cdd:PLN03209  460 GvSPSVSSTSSVPAVPDTaPATAATDAAAPPPANMRPLSPYAVYDDLKPPTSPSPA 515
KLF14_N cd21576
N-terminal domain of Kruppel-like factor 14; Kruppel-like factor 14 (KLF14; also known as ...
 270-374 6.34e-03

N-terminal domain of Kruppel-like factor 14; Kruppel-like factor 14 (KLF14; also known as Krueppel-like factor 14 or basic transcription element-binding protein 5/BTEB5) is a protein that in humans is encoded by the KLF14 gene. KLF14 regulates the transcription of various genes, including TGFbetaRII (the type II receptor for TGFbeta). KLF14 is expressed in many tissues, lacks introns, and is subject to parent-specific expression. It also appears to be a master regulator of gene expression in adipose tissue. KLF14 is associated with coronary artery disease, hypercholesterolemia, and type 2 diabetes. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved alpha-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF14 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF14.


Pssm-ID: 409238 [Multi-domain]  Cd Length: 195  Bit Score: 37.88  E-value: 6.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1771661244 270 PIAVPTPSPPSVFPAP---AGSA----------------GTPPLPATSASAPAplvPATVPSSTAPDAAAGGAQTLADGF 330
Cdd:cd21576    65 LLQVPAPSPGAGGAAPhllAASVladlrggagegsredsGEAPRASSGSSDPA---RGSSPTLGSEPAPASGEDAVSGPE 141

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1771661244 331 TSPTPPVVSSTPPT-GHPVQFYSMNRPASRHTPPTIGGSLPYRRP 374
Cdd:cd21576   142 SSFGAPAIPSAPAApGAPAVSGEVPGGAPGAGPAPAAGPAPRRRP 186
PTZ00436 PTZ00436
60S ribosomal protein L19-like protein; Provisional
 277-372 6.47e-03

60S ribosomal protein L19-like protein; Provisional


Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 38.78  E-value: 6.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1771661244 277 SPPSVFPAPAGSAGTPPLPATSASAPAPLVPATVPSSTAPDAAAGGAQTLADGFTSPTPPVVSSTPPTGHPVQFYSMNRP 356
Cdd:PTZ00436  248 AAPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAAPAKAAAAPAKAAAAPAKAAAPPAKAAAPP 327

                          90
                  ....*....|....*.
gi 1771661244 357 ASRHTPPTIGGSLPYR 372
Cdd:PTZ00436  328 AKAATPPAKAAAPPAK 343
PHA03291 PHA03291
envelope glycoprotein I; Provisional
 270-344 6.92e-03

envelope glycoprotein I; Provisional


Pssm-ID: 223033 [Multi-domain]  Cd Length: 401  Bit Score: 38.78  E-value: 6.92e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1771661244 270 PIAVPTPSPPSVFPAPAGSAGTPPLPATSASAPAPLVPATVPSSTAPDAAAGGAqtlADGFTSPTPPVVSSTPPT 344
Cdd:PHA03291  199 PADVFVPATPRPTPRTTASPETTPTPSTTTSPPSTTIPAPSTTIAAPQAGTTPE---AEGTPAPPTPGGGEAPPA 270
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 272-347 7.12e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 39.08  E-value: 7.12e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1771661244 272 AVPTPSPPSVFPAPAGSAGTPPLPATSASAPAPLVPATVPSSTAPDAAAGGAQTLADGFTSPTPPVVSSTPPTGHP 347
Cdd:PRK07994  364 PLPEPEVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQLQRAQGATKAK 439
FAP pfam07174
Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment ...
 269-343 9.17e-03

Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment proteins (FAP). Family members are rich in alanine and proline, are approximately 300 long, and seem to be restricted to mycobacteria. These proteins contain a fibronectin-binding motif that allows mycobacteria to bind to fibronectin in the extracellular matrix.


Pssm-ID: 429334  Cd Length: 301  Bit Score: 38.37  E-value: 9.17e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1771661244 269 VPIAVPTPSPPSVFPAPAGSAGTPPLPATSASAPAPLVPATVPSSTAPDaAAGGAQTLADGFTSPTPPVVSSTPP 343
Cdd:pfam07174  29 VAVALPAVAHADPEPAPPPPSTATAPPAPPPPPPAPAAPAPPPPPAAPN-APNAPPPPADPNAPPPPPADPNAPP 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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