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Conserved domains on  [gi|1835922450|ref|NP_001369248|]
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solute carrier family 22 member 23 isoform f [Homo sapiens]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 3-283 1.16e-108

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17444:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 364  Bit Score: 320.26  E-value: 1.16e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835922450   3 TISVVGIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYWSIFPeslrwlmatqqfesa 82
Cdd:cd17444   109 SLYALRIELCPPGHRFMITMVASFIAMAGQFLMPGLAALCRDWQVLQAVIICPFLLMLSYWCIFP--------------- 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835922450  83 krlilhftqknrmnpegdikgvipelekelsrrpkkvcivkvvgtrnlwKNIVVLCVNSLTGYGIHHCFARSMMGHEVKV 162
Cdd:cd17444   174 -------------------------------------------------KNIVVLCVNSLTGYGIHHCFAKSMMDHEMKG 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835922450 163 PLLENFYADYYTTASIALVSCLAMCVVVRFLGRRGGLLLFMILTALASLLQLGLLNLIGKYSQHPDSGMSDSVKDKFSIA 242
Cdd:cd17444   205 SFLHNFYAEYYTMAVIALASCLAMCPVVGFLGRRGGLLLFMILTALASLLQLGLLNLIGKYSQHPDSGMSDEVKDKFSVT 284

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1835922450 243 FSIVGMFASHAVGSLSVFFCAEITPTVIRC-VMGDTPGDAGF 283
Cdd:cd17444   285 FSIVGMFSSHAVGSLSVFFCAEITPTVIRGgGLGLVLASAGF 326
 
Name Accession Description Interval E-value
MFS_SLC22A23 cd17444
Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier ...
 3-283 1.16e-108

Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier family 22, member 23 (SLC22A23) is an orphan member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It is abundantly expressed in brain and is also found in liver. Single-nucleotide polymorphisms in SLC22A23 are associated with inflammatory bowel disease (IBD) in a Canadian white population. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A23 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341002 [Multi-domain]  Cd Length: 364  Bit Score: 320.26  E-value: 1.16e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835922450   3 TISVVGIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYWSIFPeslrwlmatqqfesa 82
Cdd:cd17444   109 SLYALRIELCPPGHRFMITMVASFIAMAGQFLMPGLAALCRDWQVLQAVIICPFLLMLSYWCIFP--------------- 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835922450  83 krlilhftqknrmnpegdikgvipelekelsrrpkkvcivkvvgtrnlwKNIVVLCVNSLTGYGIHHCFARSMMGHEVKV 162
Cdd:cd17444   174 -------------------------------------------------KNIVVLCVNSLTGYGIHHCFAKSMMDHEMKG 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835922450 163 PLLENFYADYYTTASIALVSCLAMCVVVRFLGRRGGLLLFMILTALASLLQLGLLNLIGKYSQHPDSGMSDSVKDKFSIA 242
Cdd:cd17444   205 SFLHNFYAEYYTMAVIALASCLAMCPVVGFLGRRGGLLLFMILTALASLLQLGLLNLIGKYSQHPDSGMSDEVKDKFSVT 284

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1835922450 243 FSIVGMFASHAVGSLSVFFCAEITPTVIRC-VMGDTPGDAGF 283
Cdd:cd17444   285 FSIVGMFSSHAVGSLSVFFCAEITPTVIRGgGLGLVLASAGF 326
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 6-271 3.21e-15

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 75.82  E-value: 3.21e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835922450   6 VVGIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYWSIFPESLRWLMATQQFESAKRL 85
Cdd:TIGR00898 203 VLNTEFLPKKQRAIVGTLIQVFFSLGLVLLPLVAYFIPDWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIEEALKI 282

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835922450  86 ILHFTQKNRMNPEGDIKgvIPELEKELSRRPKKVCIVKVVGTRNL-WKNIVVLCV---NSLTGYGIhhcfarsMMGHEVk 161
Cdd:TIGR00898 283 LQRIAKINGKKLPAEVL--SLSLEKDLSSSKKQYSFLDLFRTPNLrKTTLCLMMLwftTAFSYYGL-------VLDLGN- 352

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835922450 162 vpLLENFYADYYTTASIALVSCLAMCVVVRFLGRR----------GGLLLFMILTALASLLQLGLLNLIGKYSqhpdsgm 231
Cdd:TIGR00898 353 --LGGNIYLDLFISGLVELPAKLITLLLIDRLGRRytmaaslllaGVALLLLLFVPVDLYFLRTALAVLGKFG------- 423

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1835922450 232 sdsvkdkFSIAFSIVGMFAshavgslsvffcAEITPTVIR 271
Cdd:TIGR00898 424 -------ITSAFQMVYLYT------------AELYPTVVR 444
Sugar_tr pfam00083
Sugar (and other) transporter;
10-201 3.91e-03

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 38.79  E-value: 3.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835922450  10 ELCPPGKR-FMITMVASFVAMaGQFLMPGLA---ALCRD---WQVLQALIICPFLLMLLYWSIFPESLRWLMATQQFESA 82
Cdd:pfam00083 129 EIAPKKLRgALGSLYQLAITF-GILLAYIFGlglNKTSNsdgWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEA 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835922450  83 KRLIlhftqKNRMNPEGDIKGVIPELEK-ELSRRPKKVCIVKVVGTRNLWKNIVVLCV----------NSLTGYGihhcf 151
Cdd:pfam00083 208 REVL-----AKLRGVPDVDRELDEIKDSlEAGQEAEKASWKELFSTKTRRQRLLIGVMlqifqqltgiNAIFYYS----- 277

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1835922450 152 arSMMGHEVKVPllenfyADYYTTASIALVSCLAMCV---VVRFLGRRGGLLL 201
Cdd:pfam00083 278 --TTIFENLGLS------DSFLVTIIVGVVNFVFTFIaifLVDRFGRRPLLLL 322
 
Name Accession Description Interval E-value
MFS_SLC22A23 cd17444
Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier ...
 3-283 1.16e-108

Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier family 22, member 23 (SLC22A23) is an orphan member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It is abundantly expressed in brain and is also found in liver. Single-nucleotide polymorphisms in SLC22A23 are associated with inflammatory bowel disease (IBD) in a Canadian white population. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A23 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341002 [Multi-domain]  Cd Length: 364  Bit Score: 320.26  E-value: 1.16e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835922450   3 TISVVGIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYWSIFPeslrwlmatqqfesa 82
Cdd:cd17444   109 SLYALRIELCPPGHRFMITMVASFIAMAGQFLMPGLAALCRDWQVLQAVIICPFLLMLSYWCIFP--------------- 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835922450  83 krlilhftqknrmnpegdikgvipelekelsrrpkkvcivkvvgtrnlwKNIVVLCVNSLTGYGIHHCFARSMMGHEVKV 162
Cdd:cd17444   174 -------------------------------------------------KNIVVLCVNSLTGYGIHHCFAKSMMDHEMKG 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835922450 163 PLLENFYADYYTTASIALVSCLAMCVVVRFLGRRGGLLLFMILTALASLLQLGLLNLIGKYSQHPDSGMSDSVKDKFSIA 242
Cdd:cd17444   205 SFLHNFYAEYYTMAVIALASCLAMCPVVGFLGRRGGLLLFMILTALASLLQLGLLNLIGKYSQHPDSGMSDEVKDKFSVT 284

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1835922450 243 FSIVGMFASHAVGSLSVFFCAEITPTVIRC-VMGDTPGDAGF 283
Cdd:cd17444   285 FSIVGMFSSHAVGSLSVFFCAEITPTVIRGgGLGLVLASAGF 326
MFS_SLC22A17_like cd17373
Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; ...
 9-272 2.15e-86

Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; This group is composed of Solute carrier family 22, members 17, 23, and 31. They are members of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). SLC22A17 functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. SLC22A23 and SLC22A31 are orphan members of the SLC22 family. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22A17-like group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340931 [Multi-domain]  Cd Length: 348  Bit Score: 263.22  E-value: 2.15e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835922450   9 IELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYWSIFPeslrwlmatqqfesakrlilh 88
Cdd:cd17373   104 LELCDPGKRLMITMVASLVAVAGQFLMPGLAALCRDWRVLQALIICPFLLMLLYWSIFP--------------------- 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835922450  89 ftqknrmnpegdikgvipelekelsrrpkkvcivkvvgtrnlwKNIVVLCVNSLTGYGIHHCFARSMMGHEVkvpllENF 168
Cdd:cd17373   163 -------------------------------------------KNILILGFNSLTGYGIRHCFARSMMGHEP-----ENF 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835922450 169 YADYYTTASIALVSCLAMCVVVRFLGRRGGLLLFMILTALASLLQLGLLNLIGKYSQHPDSGMSDSVKDKFSIAFSIVGM 248
Cdd:cd17373   195 YLDYYLTAGIAAVACVFLCVTVDFLGRRGGLLLFMILTGLASLLLLGLLNLIGKYSQHPDSGMSDSVKDKFSIAFSVLGL 274

                         250       260
                  ....*....|....*....|....
gi 1835922450 249 FASHAVGSLSVFFCAEITPTVIRC 272
Cdd:cd17373   275 FASHAVGSLSVLFAAEVTPTVIRG 298
MFS_SLC22A31 cd17443
Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier ...
 9-271 7.36e-31

Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier family 22, member 31 (SLC22A31) is an uncharacterized member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A31 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341001 [Multi-domain]  Cd Length: 343  Bit Score: 118.73  E-value: 7.36e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835922450   9 IELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYWSifpeslrwlmatqqFESAKRLILH 88
Cdd:cd17443   115 LELCDPSHRLMVSMGAGFFSVAGELLLPGLAVLCRDWRVLQGVGTLPLLLLLLYWC--------------FPSRNGLILG 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835922450  89 FTqknrmnpegdikgvipelekelsrrpkkvcivkvvgtrnlwknivvlcvnSLTGYGIHHCFARSMMghevkvPLLENF 168
Cdd:cd17443   181 FT--------------------------------------------------AFIGGGIRYCFARNLA------PFVPTF 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835922450 169 YADYYTTASIALVSCLAMCVVVRFLGRRGGLLLFMILTALASLLQLgllnligkysqhpdsGMSDSVKDKFSIAFSIVGM 248
Cdd:cd17443   205 YLPYFLQAGLEALACIFLCLTVDRCGRRGVLLLGTIVTGLSSLLLL---------------ALTQYLHGGLVLVLSVVGL 269

                         250       260
                  ....*....|....*....|...
gi 1835922450 249 FASHAVGSLSVFFCAEITPTVIR 271
Cdd:cd17443   270 LASHAVSMLSMFFAAEVLPTVIR 292
MFS_SLC22A17 cd17445
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier ...
 3-271 1.09e-24

Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier family 22, member 17 (SLC22A17) is also called 24p3 receptor (24p3R), lipocalin-2 receptor, or neutrophil gelatinase-associated lipocalin (NGAL) receptor (NGALR). It functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. LCN2 is a secreted protein of the lipocalin family that induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore. Over-expressions of NGAL and NGALR have been found to be correlated with unfavorable clinicopathologic features and poor prognosis of patients with hepatocellular carcinoma. SLC22A17 is a member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341003 [Multi-domain]  Cd Length: 346  Bit Score: 101.77  E-value: 1.09e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835922450   3 TISVVGIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYwsifpeslrwlmatqqfesa 82
Cdd:cd17445   109 TLYLTRLELCDPPQRLLVAMAGGLTMVGGHFLLLGLALGCGSWRVLQGTITAPLSLFLCY-------------------- 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835922450  83 krlilhftqknrmnpegDIKGVipelekelsrrpkkvcivkvvgtrnlwKNIVVLCVNSLTGYGIHHCFarSMMGHEVKv 162
Cdd:cd17445   169 -----------------GCPGV---------------------------KNLLILGFTTFIAHAISHCY--QSFSDDVR- 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835922450 163 PLLENFYADYYTTASIALVSCLAMCVVVRFLGRRGGLLLFMILTALASLLQLgllnligkysqhpdsGMSDSVKDKFSIA 242
Cdd:cd17445   202 GTPSTFYLSYLLSTGTAGLACLFLCATVDRFGRRGILLLAMTLTGIASLILL---------------GLMDYLNDAAIKT 266

                         250       260
                  ....*....|....*....|....*....
gi 1835922450 243 FSIVGMFASHAVGSLSVFFCAEITPTVIR 271
Cdd:cd17445   267 FSILGLFSSQAAASLSILFAAEVIPTVIR 295
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 6-271 3.21e-15

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 75.82  E-value: 3.21e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835922450   6 VVGIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYWSIFPESLRWLMATQQFESAKRL 85
Cdd:TIGR00898 203 VLNTEFLPKKQRAIVGTLIQVFFSLGLVLLPLVAYFIPDWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIEEALKI 282

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835922450  86 ILHFTQKNRMNPEGDIKgvIPELEKELSRRPKKVCIVKVVGTRNL-WKNIVVLCV---NSLTGYGIhhcfarsMMGHEVk 161
Cdd:TIGR00898 283 LQRIAKINGKKLPAEVL--SLSLEKDLSSSKKQYSFLDLFRTPNLrKTTLCLMMLwftTAFSYYGL-------VLDLGN- 352

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835922450 162 vpLLENFYADYYTTASIALVSCLAMCVVVRFLGRR----------GGLLLFMILTALASLLQLGLLNLIGKYSqhpdsgm 231
Cdd:TIGR00898 353 --LGGNIYLDLFISGLVELPAKLITLLLIDRLGRRytmaaslllaGVALLLLLFVPVDLYFLRTALAVLGKFG------- 423

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1835922450 232 sdsvkdkFSIAFSIVGMFAshavgslsvffcAEITPTVIR 271
Cdd:TIGR00898 424 -------ITSAFQMVYLYT------------AELYPTVVR 444
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 6-271 2.21e-09

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 57.59  E-value: 2.21e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835922450   6 VVGIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYWsifpeslrWLMatqqfesakrl 85
Cdd:cd17317   101 VLGMEIVGPKYRSFVGILFGLFWALGYMLLALLAYLIRDWRWLQLAISLPGLLFLLLL--------WWL----------- 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835922450  86 ilhftqknrmnpegdikgvipelekelsrrPKKVCIVkvvgtrnlwknIVVLCVNSLTGYGIhhcfarSMMGHEvkvpLL 165
Cdd:cd17317   162 ------------------------------PRRTIIV-----------GLIWFVTSLVYYGL------SLNSSN----LG 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835922450 166 ENFYADYYTTASIALVSCLAMCVVVRFLGRRGGLLLFMILTAlasllqlGLLNLIGKYSQHPDSgmsdsvkdkFSIAFSI 245
Cdd:cd17317   191 GNLYLNFFLSGLVEIPAYFLALLLLDRLGRRWTLSGSLLLAG-------LACLVTALLPDDENT---------LALTLAL 254

                         250       260
                  ....*....|....*....|....*.
gi 1835922450 246 VGMFASHAVGSLSVFFCAEITPTVIR 271
Cdd:cd17317   255 VGKFAISAAFSVIYLYTAELYPTVVR 280
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 6-67 3.89e-05

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 44.59  E-value: 3.89e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1835922450   6 VVGIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYWSIFP 67
Cdd:cd17374   111 ILGTEWTTPRHRALAITLTSCFFSIGQMLLAGLAYAIRDWRLLQLVVSVPFFLFFLYSWWLP 172
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 18-274 3.15e-04

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 42.25  E-value: 3.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835922450  18 FMITMVASFVAMAGQFL-MPGLAALCRDWQVLQALIICPFLLMLLYWSIFPESLRWLMATQQFESAKRLILHFTQknrmN 96
Cdd:cd17357   144 SLTQIGVTLGILLGQVFgLPSVLGTETLWPYLLFFPGIPALLQLAALPFFPESPKFLLISKGDEEEAEKSLKFLR----G 219

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835922450  97 PEGDIKGVIPELEKELSR--RPKKVCIVKVVGTRNLWKNIVVLCVNSLTGY--GIHHCFARSM-----MGHEVKVPLLEN 167
Cdd:cd17357   220 IEDDVDQELEEIKKESEQmgDQKQVSLMQLLRDPSLRLPLLLVLVVSASQQfsGINAIFFYSTfifenAGFSPQLAEWAN 299

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835922450 168 FYADYYTTASialvSCLAMcVVVRFLGRRGGLLLFMILTAlasllQLGLLNLIGKYSQHPDSGMSdsvkdKFSIAFSIV- 246
Cdd:cd17357   300 LGIGIVNVLS----TIVGP-FLIEKVGRRPLLLISLSVCA-----VALLLMSVFLFLSEQNSWMS-----YGCIVAIFLf 364

                         250       260
                  ....*....|....*....|....*...
gi 1835922450 247 GMFASHAVGSLSVFFCAEITPTVIRCVM 274
Cdd:cd17357   365 IFFFAIGLGPIPWFIGAELFPQAPRSAA 392
MFS_SLC22A6_OAT1_like cd17446
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ...
 9-67 5.79e-04

Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341004 [Multi-domain]  Cd Length: 339  Bit Score: 41.25  E-value: 5.79e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1835922450   9 IELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYWSIFP 67
Cdd:cd17446   112 VEWMPTRVRAVVGTLLGYCYTLGQLILAGVAYAIRDWRWLQLAVSLPFFIFFLYSWWFP 170
Sugar_tr pfam00083
Sugar (and other) transporter;
10-201 3.91e-03

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 38.79  E-value: 3.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835922450  10 ELCPPGKR-FMITMVASFVAMaGQFLMPGLA---ALCRD---WQVLQALIICPFLLMLLYWSIFPESLRWLMATQQFESA 82
Cdd:pfam00083 129 EIAPKKLRgALGSLYQLAITF-GILLAYIFGlglNKTSNsdgWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEA 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835922450  83 KRLIlhftqKNRMNPEGDIKGVIPELEK-ELSRRPKKVCIVKVVGTRNLWKNIVVLCV----------NSLTGYGihhcf 151
Cdd:pfam00083 208 REVL-----AKLRGVPDVDRELDEIKDSlEAGQEAEKASWKELFSTKTRRQRLLIGVMlqifqqltgiNAIFYYS----- 277

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1835922450 152 arSMMGHEVKVPllenfyADYYTTASIALVSCLAMCV---VVRFLGRRGGLLL 201
Cdd:pfam00083 278 --TTIFENLGLS------DSFLVTIIVGVVNFVFTFIaifLVDRFGRRPLLLL 322
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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