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Conserved domains on  [gi|1862722930|ref|NP_001371737|]
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microtubule-associated protein 4 isoform 129 [Homo sapiens]

Protein Classification

PHA03247 and Tubulin-binding domain-containing protein( domain architecture ID 10450448)

PHA03247 and Tubulin-binding domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 502-531 8.69e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 62.43  E-value: 8.69e-13
                          10        20        30
                  ....*....|....*....|....*....|
gi 1862722930 502 VQIVSKKVSYSHIQSKCGSKDNIKHVPGGG 531
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 533-562 1.36e-12

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 62.04  E-value: 1.36e-12
                          10        20        30
                  ....*....|....*....|....*....|
gi 1862722930 533 VQIQNKKVDISKVSSKCGSKANIKHKPGGG 562
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 180-429 1.41e-10

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 64.96  E-value: 1.41e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722930  180 RPEEGRPVVSGTGNDITTPPNkelPPSPEKKTKPLATTQPAKTSTSKAKTQPTSLPKQPAPTTIGGLNKKPMSLASGLVP 259
Cdd:PHA03247  2684 RRRAARPTVGSLTSLADPPPP---PPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARP 2760

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722930  260 AAP--PKRPAVASARPSILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPS 337
Cdd:PHA03247  2761 PTTagPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPP 2840

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722930  338 TLLPKKPTAIKTEGKPAE----VKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAA--GVVPSRVKATPMPSRPSTT 411
Cdd:PHA03247  2841 PPPGPPPPSLPLGGSVAPggdvRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFAlpPDQPERPPQPQAPPPPQPQ 2920

                          250
                   ....*....|....*...
gi 1862722930  412 PFIDKKPTSAKPSSTTPR 429
Cdd:PHA03247  2921 PQPPPPPQPQPPPPPPPR 2938
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 564-594 2.08e-08

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 50.10  E-value: 2.08e-08
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1862722930 564 VKIESQKLNFKeKAQAKVGSLDNVGHLPAGG 594
Cdd:pfam00418   1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 441-462 8.42e-08

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 48.56  E-value: 8.42e-08
                          10        20
                  ....*....|....*....|..
gi 1862722930 441 DLKNVRSKVGSTENIKHQPGGG 462
Cdd:pfam00418   9 DFSKVQSKCGSKDNIKHKPGGG 30
 
Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 502-531 8.69e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 62.43  E-value: 8.69e-13
                          10        20        30
                  ....*....|....*....|....*....|
gi 1862722930 502 VQIVSKKVSYSHIQSKCGSKDNIKHVPGGG 531
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 533-562 1.36e-12

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 62.04  E-value: 1.36e-12
                          10        20        30
                  ....*....|....*....|....*....|
gi 1862722930 533 VQIQNKKVDISKVSSKCGSKANIKHKPGGG 562
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
PHA03247 PHA03247
large tegument protein UL36; Provisional
 180-429 1.41e-10

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 64.96  E-value: 1.41e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722930  180 RPEEGRPVVSGTGNDITTPPNkelPPSPEKKTKPLATTQPAKTSTSKAKTQPTSLPKQPAPTTIGGLNKKPMSLASGLVP 259
Cdd:PHA03247  2684 RRRAARPTVGSLTSLADPPPP---PPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARP 2760

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722930  260 AAP--PKRPAVASARPSILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPS 337
Cdd:PHA03247  2761 PTTagPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPP 2840

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722930  338 TLLPKKPTAIKTEGKPAE----VKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAA--GVVPSRVKATPMPSRPSTT 411
Cdd:PHA03247  2841 PPPGPPPPSLPLGGSVAPggdvRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFAlpPDQPERPPQPQAPPPPQPQ 2920

                          250
                   ....*....|....*...
gi 1862722930  412 PFIDKKPTSAKPSSTTPR 429
Cdd:PHA03247  2921 PQPPPPPQPQPPPPPPPR 2938
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 564-594 2.08e-08

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 50.10  E-value: 2.08e-08
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1862722930 564 VKIESQKLNFKeKAQAKVGSLDNVGHLPAGG 594
Cdd:pfam00418   1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 441-462 8.42e-08

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 48.56  E-value: 8.42e-08
                          10        20
                  ....*....|....*....|..
gi 1862722930 441 DLKNVRSKVGSTENIKHQPGGG 462
Cdd:pfam00418   9 DFSKVQSKCGSKDNIKHKPGGG 30
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 171-494 3.48e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 43.75  E-value: 3.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722930 171 PLKDSYGIARPEegrpVVSGTGNDITTPPNKELPPS--PEKKTKPLATTQPAKTSTSKAKTQPTSLPKQPAPTTIGGLNK 248
Cdd:pfam05109 432 PTLNTTGFAAPN----TTTGLPSSTHVPTNLTAPAStgPTVSTADVTSPTPAGTTSGASPVTPSPSPRDNGTESKAPDMT 507

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722930 249 KPMSLASGLVPAAPPKRPAVASARPSILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVAS 328
Cdd:pfam05109 508 SPTSAVTTPTPNATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNATIPTLGKTSPTSAVTTPT 587

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722930 329 TGPSSRSPSTLLPKKPTAIKTEGKPAEVKKMTA--KSVPADLSRPKSTSTSSMKKTTTLSGTAPAAGVVPSRV--KATPM 404
Cdd:pfam05109 588 PNATSPTVGETSPQANTTNHTLGGTSSTPVVTSppKNATSAVTTGQHNITSSSTSSMSLRPSSISETLSPSTSdnSTSHM 667

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722930 405 PSRPSTTPFIDKKPTSAKPSSTTPRlsRLATNTSAPDlKNVRSKVGSTENIKHQPGGGRAKVEKKTEAAATTrKPESNAV 484
Cdd:pfam05109 668 PLLTSAHPTGGENITQVTPASTSTH--HVSTSSPAPR-PGTTSQASGPGNSSTSTKPGEVNVTKGTPPKNAT-SPQAPSG 743

                         330
                  ....*....|
gi 1862722930 485 TKTAGPIASA 494
Cdd:pfam05109 744 QKTAVPTVTS 753
 
Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 502-531 8.69e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 62.43  E-value: 8.69e-13
                          10        20        30
                  ....*....|....*....|....*....|
gi 1862722930 502 VQIVSKKVSYSHIQSKCGSKDNIKHVPGGG 531
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 533-562 1.36e-12

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 62.04  E-value: 1.36e-12
                          10        20        30
                  ....*....|....*....|....*....|
gi 1862722930 533 VQIQNKKVDISKVSSKCGSKANIKHKPGGG 562
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
PHA03247 PHA03247
large tegument protein UL36; Provisional
 180-429 1.41e-10

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 64.96  E-value: 1.41e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722930  180 RPEEGRPVVSGTGNDITTPPNkelPPSPEKKTKPLATTQPAKTSTSKAKTQPTSLPKQPAPTTIGGLNKKPMSLASGLVP 259
Cdd:PHA03247  2684 RRRAARPTVGSLTSLADPPPP---PPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARP 2760

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722930  260 AAP--PKRPAVASARPSILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPS 337
Cdd:PHA03247  2761 PTTagPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPP 2840

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722930  338 TLLPKKPTAIKTEGKPAE----VKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAA--GVVPSRVKATPMPSRPSTT 411
Cdd:PHA03247  2841 PPPGPPPPSLPLGGSVAPggdvRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFAlpPDQPERPPQPQAPPPPQPQ 2920

                          250
                   ....*....|....*...
gi 1862722930  412 PFIDKKPTSAKPSSTTPR 429
Cdd:PHA03247  2921 PQPPPPPQPQPPPPPPPR 2938
PHA03247 PHA03247
large tegument protein UL36; Provisional
 166-435 1.53e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 58.41  E-value: 1.53e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722930  166 AGQNDPLKDSYGIARPEEGRPVVSGTGNDITTPPNKELPPSPEKKTKPLATTQPAKTSTSKAKTQPTS----LPKQPAPT 241
Cdd:PHA03247  2728 ARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESReslpSPWDPADP 2807

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722930  242 TIGGLNKKPmSLASGLVPAAP-PKRPAVASARPSILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKT 320
Cdd:PHA03247  2808 PAAVLAPAA-ALPPAASPAGPlPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRL 2886

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722930  321 TTAAAVASTGPSSRSPSTLLPKKPTAIKTEGKPAEVKKMTAKSVPADlsRPKSTSTSSMKKTTTLSGTAPAAGVVPSRVK 400
Cdd:PHA03247  2887 ARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPP--PPPPRPQPPLAPTTDPAGAGEPSGAVPQPWL 2964

                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 1862722930  401 ATPMPSRPSTTPFI--DKKPTSAKPSSTTPRLSRLAT 435
Cdd:PHA03247  2965 GALVPGRVAVPRFRvpQPAPSREAPASSTPPLTGHSL 3001
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 564-594 2.08e-08

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 50.10  E-value: 2.08e-08
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1862722930 564 VKIESQKLNFKeKAQAKVGSLDNVGHLPAGG 594
Cdd:pfam00418   1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 441-462 8.42e-08

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 48.56  E-value: 8.42e-08
                          10        20
                  ....*....|....*....|..
gi 1862722930 441 DLKNVRSKVGSTENIKHQPGGG 462
Cdd:pfam00418   9 DFSKVQSKCGSKDNIKHKPGGG 30
PHA03247 PHA03247
large tegument protein UL36; Provisional
 179-498 3.05e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.17  E-value: 3.05e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722930  179 ARPEEGRPVVSG--TGNDITTPPNKELPPSPEKKTKPLATTQPAKTSTSKAKTQPTSLPKQPAPTTIGGlnkkpmslasg 256
Cdd:PHA03247  2591 APPQSARPRAPVddRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPG----------- 2659

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722930  257 lvpAAPPKRPAVASARPSILPSKDVKPKPIA--DAKAP-EKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSS 333
Cdd:PHA03247  2660 ---RVSRPRRARRLGRAAQASSPPQRPRRRAarPTVGSlTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALP 2736

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722930  334 RSPSTllPKKPTAIKTEGKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTttlsgTAPAAGVVPSRVKATPMPSRPSTTPF 413
Cdd:PHA03247  2737 AAPAP--PAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRL-----TRPAVASLSESRESLPSPWDPADPPA 2809

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722930  414 IDKKPTSAKPSSTTPRlSRLATNTS----APDLKNVRSKVGSTENIKHQPGGGRAKVEKKTEAAATTRKPESNAVTKTAG 489
Cdd:PHA03247  2810 AVLAPAAALPPAASPA-GPLPPPTSaqptAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLAR 2888


                   ....*....
gi 1862722930  490 PIASAQKQP 498
Cdd:PHA03247  2889 PAVSRSTES 2897
PHA03247 PHA03247
large tegument protein UL36; Provisional
 204-499 1.28e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.86  E-value: 1.28e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722930  204 PPSPEKKTKPlattqPAKTSTSKAKTQPTSLPKQPAPTTIGGLNKKPMSLASGLVPAAPPKRPAvASARPSILPSKDVKP 283
Cdd:PHA03247  2551 PPPPLPPAAP-----PAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPR-GPAPPSPLPPDTHAP 2624

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722930  284 KPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIktegkPAEVKKMTAKS 363
Cdd:PHA03247  2625 DPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAA-----RPTVGSLTSLA 2699

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722930  364 VPADLSRPKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPMPSRPSTTPFID-------KKPTSAKPSSTTPRLSRLATN 436
Cdd:PHA03247  2700 DPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPggparpaRPPTTAGPPAPAPPAAPAAGP 2779

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1862722930  437 TSAPDLKNVRSKVGSTENI--KHQPGGGRAKVEKKTEAAATTRKPESNAVTKTAGPIASAQKQPA 499
Cdd:PHA03247  2780 PRRLTRPAVASLSESRESLpsPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPG 2844
PHA03247 PHA03247
large tegument protein UL36; Provisional
 155-434 1.32e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.86  E-value: 1.32e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722930  155 PSSATADTSIFAGQNDPLKDSYGIARPEEGRPVVSGTGNDITTPPNKELPPSPEKKTKPLA--TTQPAKTSTSKAKTQPT 232
Cdd:PHA03247  2598 PRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPgrVSRPRRARRLGRAAQAS 2677

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722930  233 SLPKQP----APTTIGGLN---------KKPMSLASGLVPAAPPkrPAVASARPSILPSKDVKPKPIADAKAPEKRASPS 299
Cdd:PHA03247  2678 SPPQRPrrraARPTVGSLTsladpppppPTPEPAPHALVSATPL--PPGPAAARQASPALPAAPAPPAVPAGPATPGGPA 2755

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722930  300 KPASaPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIKTEGKPAEVkkmtakSVPADLSRPKSTSTSSM 379
Cdd:PHA03247  2756 RPAR-PPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAV------LAPAAALPPAASPAGPL 2828

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1862722930  380 KKTTTLSGTAPAAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKP----SSTTPRLSRLA 434
Cdd:PHA03247  2829 PPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAakpaAPARPPVRRLA 2887
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 130-500 2.11e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 47.86  E-value: 2.11e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722930  130 EQVVDPIQTDPFKMYHDDDLADLVFPSSATADTSIFAGQNDPLKDSYGIARPEEGRPVVSGTGNDITT----PPNKELPP 205
Cdd:PHA03307    30 DAADDLLSGSQGQLVSDSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPaspaREGSPTPP 109

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722930  206 SPEKKTKPLATTQPAktstSKAKTQPTSLPKQPAPTTIGGLNKKPMSLASGLVPAAPPKRPA------------VASARP 273
Cdd:PHA03307   110 GPSSPDPPPPTPPPA----SPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAAssrqaalplsspEETARA 185

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722930  274 SILPSKDVKPKPIADAKAPEKRAsPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSR----SPSTLLPKKPTAikt 349
Cdd:PHA03307   186 PSSPPAEPPPSTPPAAASPRPPR-RSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSgcgwGPENECPLPRPA--- 261

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722930  350 egkPAEVKKMTAKSVPADLSRPKSTSTSSmkkTTTLSGTAPAAgvVPSRVKATPMPSRPSTTPFIDKKPTS--AKPSSTT 427
Cdd:PHA03307   262 ---PITLPTRIWEASGWNGPSSRPGPASS---SSSPRERSPSP--SPSSPGSGPAPSSPRASSSSSSSRESssSSTSSSS 333

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1862722930  428 PRLSRLATNTSAPdlknvrskvgSTENIKHQPGGGRAKVEKKTEAAATTRKPESNAVTKTAGPIASAQKQPAG 500
Cdd:PHA03307   334 ESSRGAAVSPGPS----------PSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAG 396
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
186-440 2.72e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 47.54  E-value: 2.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722930 186 PVVSGTGnditTPPNKELPPSPEKKTKPLATTQPAKTSTSKAKTQPTSLPKQPAPTTigglnkKPMSLASGLVPAAPPKR 265
Cdd:PRK07003  360 PAVTGGG----APGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAP------KAAAAAAATRAEAPPAA 429

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722930 266 PAVASA-----RPSILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLL 340
Cdd:PRK07003  430 PAPPATadrgdDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPD 509

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722930 341 PKKPTAIKTEGKPAEVKKMTAKSVPA------------------DLSRPKSTSTSSMKKTTTLSGTAPAAGVVPSRVKAT 402
Cdd:PRK07003  510 ARAPAAASREDAPAAAAPPAPEARPPtpaaaapaaraggaaaalDVLRNAGMRVSSDRGARAAAAAKPAAAPAAAPKPAA 589

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1862722930 403 PMPSRPSTTPFIDKKPTSAKPSSTTPRLSRLATNTSAP 440
Cdd:PRK07003  590 PRVAVQVPTPRARAATGDAPPNGAARAEQAAESRGAPP 627
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 155-438 1.52e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 45.07  E-value: 1.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722930 155 PSSATADTSIFAGQNDPLKDSYgiARPEEGRPVVSGTGNDITTP-PNKELPPS--------PEKKTKPLATTQPAKTSTS 225
Cdd:PTZ00449  520 PPKAPGDKEGEEGEHEDSKESD--EPKEGGKPGETKEGEVGKKPgPAKEHKPSkiptlskkPEFPKDPKHPKDPEEPKKP 597

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722930 226 KAKTQPTSLPKQPAPttigglnKKPMSLAsglVPAAPPKRPAVASARPSILPSKDVKPKPIADAKAPEKRASPSKPA--- 302
Cdd:PTZ00449  598 KRPRSAQRPTRPKSP-------KLPELLD---IPKSPKRPESPKSPKRPPPPQRPSSPERPEGPKIIKSPKPPKSPKppf 667

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722930 303 ------------SAPASRSGSKSTQTVAKTTTAAAVASTGPSS-----RSPSTLLPKKPTAIKTEGKPaeVKKMTAKSV- 364
Cdd:PTZ00449  668 dpkfkekfyddyLDAAAKSKETKTTVVLDESFESILKETLPETpgtpfTTPRPLPPKLPRDEEFPFEP--IGDPDAEQPd 745

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722930 365 PADLSRPKSTSTSSMKKTttlSGTAPAAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTP------------RLSR 432
Cdd:PTZ00449  746 DIEFFTPPEEERTFFHET---PADTPLPDILAEEFKEEDIHAETGEPDEAMKRPDSPSEHEDKPpgdhpslpkkrhRLDG 822


                  ....*.
gi 1862722930 433 LATNTS 438
Cdd:PTZ00449  823 LALSTT 828
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 171-494 3.48e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 43.75  E-value: 3.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722930 171 PLKDSYGIARPEegrpVVSGTGNDITTPPNKELPPS--PEKKTKPLATTQPAKTSTSKAKTQPTSLPKQPAPTTIGGLNK 248
Cdd:pfam05109 432 PTLNTTGFAAPN----TTTGLPSSTHVPTNLTAPAStgPTVSTADVTSPTPAGTTSGASPVTPSPSPRDNGTESKAPDMT 507

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722930 249 KPMSLASGLVPAAPPKRPAVASARPSILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVAS 328
Cdd:pfam05109 508 SPTSAVTTPTPNATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNATIPTLGKTSPTSAVTTPT 587

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722930 329 TGPSSRSPSTLLPKKPTAIKTEGKPAEVKKMTA--KSVPADLSRPKSTSTSSMKKTTTLSGTAPAAGVVPSRV--KATPM 404
Cdd:pfam05109 588 PNATSPTVGETSPQANTTNHTLGGTSSTPVVTSppKNATSAVTTGQHNITSSSTSSMSLRPSSISETLSPSTSdnSTSHM 667

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722930 405 PSRPSTTPFIDKKPTSAKPSSTTPRlsRLATNTSAPDlKNVRSKVGSTENIKHQPGGGRAKVEKKTEAAATTrKPESNAV 484
Cdd:pfam05109 668 PLLTSAHPTGGENITQVTPASTSTH--HVSTSSPAPR-PGTTSQASGPGNSSTSTKPGEVNVTKGTPPKNAT-SPQAPSG 743

                         330
                  ....*....|
gi 1862722930 485 TKTAGPIASA 494
Cdd:pfam05109 744 QKTAVPTVTS 753
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 262-423 1.01e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 42.37  E-value: 1.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722930 262 PPKRPAvASARPsilpskdvkPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPS-----SRSP 336
Cdd:PTZ00449  510 PPEGPE-ASGLP---------PKAPGDKEGEEGEHEDSKESDEPKEGGKPGETKEGEVGKKPGPAKEHKPSkiptlSKKP 579

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722930 337 StlLPKKPTAIKTEGKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTL--SGTAPAAGVVPSRVKAtpmPSRPSTT--P 412
Cdd:PTZ00449  580 E--FPKDPKHPKDPEEPKKPKRPRSAQRPTRPKSPKLPELLDIPKSPKRpeSPKSPKRPPPPQRPSS---PERPEGPkiI 654

                         170
                  ....*....|.
gi 1862722930 413 FIDKKPTSAKP 423
Cdd:PTZ00449  655 KSPKPPKSPKP 665
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
237-499 2.05e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 41.37  E-value: 2.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722930 237 QPAPTTIGGLNKKPMSLASGLVPAAPPKRPAVASAR-------PSILPSKDVKPKPIADA-----KAPEKRASPskPASA 304
Cdd:PRK07003  359 EPAVTGGGAPGGGVPARVAGAVPAPGARAAAAVGASavpavtaVTGAAGAALAPKAAAAAaatraEAPPAAPAP--PATA 436

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722930 305 PASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIKTEGKPAEVKKmtAKSVPADLSRPKSTSTSSmkkttt 384
Cdd:PRK07003  437 DRGDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAF--EPAPRAAAPSAATPAAVP------ 508

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722930 385 lsgtAPAAGVVPSRVKATPMPSRPSttpfidkkPTSAKPSSTTPRLSRLATNTSAP--DLKNVRSKVGSTeniKHQPGGG 462
Cdd:PRK07003  509 ----DARAPAAASREDAPAAAAPPA--------PEARPPTPAAAAPAARAGGAAAAldVLRNAGMRVSSD---RGARAAA 573

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1862722930 463 RAKVEKKTEAAATTRKPESNAVTKTAGPIASAQKQPA 499
Cdd:PRK07003  574 AAKPAAAPAAAPKPAAPRVAVQVPTPRARAATGDAPP 610
PHA03247 PHA03247
large tegument protein UL36; Provisional
 171-405 2.21e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 2.21e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722930  171 PLKDSYGIARPEEGRPVVSGTGNDITTPPNKELPPS--PEKKTKPLATTQPAKTSTSKAKTQPtSLPKQPAPTTIGGLNK 248
Cdd:PHA03247  2786 PAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAasPAGPLPPPTSAQPTAPPPPPGPPPP-SLPLGGSVAPGGDVRR 2864

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722930  249 KPMSLASGLVPAAPPKRPAVASARPSILPSKDV------------KPKPIADAKAPEKRASPSKPASAPASRSGSKSTQT 316
Cdd:PHA03247  2865 RPPSRSPAAKPAAPARPPVRRLARPAVSRSTESfalppdqperppQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLA 2944

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722930  317 VAKTTTAAAVASTGPSSRSPSTLLPkkptaikteGKPAEVKKMTAKSVPadlSRPKSTSTSSMKKTTTLSGTAPAAGVVP 396
Cdd:PHA03247  2945 PTTDPAGAGEPSGAVPQPWLGALVP---------GRVAVPRFRVPQPAP---SREAPASSTPPLTGHSLSRVSSWASSLA 3012


                   ....*....
gi 1862722930  397 SRVKATPMP 405
Cdd:PHA03247  3013 LHEETDPPP 3021
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 151-440 2.82e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 41.06  E-value: 2.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722930 151 DLVFPSSATADTSIFAGQNDPlkdSYGIARPEEGRPVVSGTG--NDITTPPNKELPPSPEKKTKPLATTQP--AKTSTSK 226
Cdd:pfam05109 505 DMTSPTSAVTTPTPNATSPTP---AVTTPTPNATSPTLGKTSptSAVTTPTPNATSPTPAVTTPTPNATIPtlGKTSPTS 581

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722930 227 AKTQPTslPKQPAPT-------------TIGGLNKKPmslasglVPAAPPKRP--AVASARPSILPSK----DVKPKPIA 287
Cdd:pfam05109 582 AVTTPT--PNATSPTvgetspqanttnhTLGGTSSTP-------VVTSPPKNAtsAVTTGQHNITSSStssmSLRPSSIS 652

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722930 288 DAKAPEK--RASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTG-PSSRSPSTLLPKKPTAIKTEGKPAEV-------- 356
Cdd:pfam05109 653 ETLSPSTsdNSTSHMPLLTSAHPTGGENITQVTPASTSTHHVSTSsPAPRPGTTSQASGPGNSSTSTKPGEVnvtkgtpp 732

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722930 357 KKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAAGV-VPSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTPRLSRLAT 435
Cdd:pfam05109 733 KNATSPQAPSGQKTAVPTVTSTGGKANSTTGGKHTTGHgARTSTEPTTDYGGDSTTPRTRYNATTYLPPSTSSKLRPRWT 812


                  ....*
gi 1862722930 436 NTSAP 440
Cdd:pfam05109 813 FTSPP 817
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
229-437 4.84e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 40.24  E-value: 4.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722930 229 TQPTSLPKQPAPTTIGGLNKKPMSLASGLVPAAPPKRPAVASARPSILPSKDVKPKPIADAKAPEKRASPSKPASAPASR 308
Cdd:PRK12323  372 AGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPA 451

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722930 309 SgskstQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIKTEGKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGT 388
Cdd:PRK12323  452 P-----APAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVAESI 526

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1862722930 389 APAAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTPRLSRLATNT 437
Cdd:PRK12323  527 PDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPD 575
PHA03378 PHA03378
EBNA-3B; Provisional
 202-502 5.01e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 40.05  E-value: 5.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722930 202 ELPPSPEKKTKPLATTQPAKTSTSKAKTQPTSLPKQPAPTTIGGLNKKPMSLASGLVP-AAPPKRPAVASARPSILPSKD 280
Cdd:PHA03378  573 QIQPLTSPTTSQLASSAPSYAQTPWPVPHPSQTPEPPTTQSHIPETSAPRQWPMPLRPiPMRPLRMQPITFNVLVFPTPH 652

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722930 281 VKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIKTEGKPAEVKKMT 360
Cdd:PHA03378  653 QPPQVEITPYKPTWTQIGHIPYQPSPTGANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPG 732

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722930 361 AKSVPADL---SRPKSTSTSSMKKTTTLSGTAPAAGVVPSRvkATPMPsRPSTTPFIDKKPTSAKPSSTTPRLSRLATNT 437
Cdd:PHA03378  733 RARPPAAApgrARPPAAAPGRARPPAAAPGRARPPAAAPGA--PTPQP-PPQAPPAPQQRPRGAPTPQPPPQAGPTSMQL 809

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1862722930 438 SAPDLKNVRskvGSTENIKHQPGGGRAKvekktEAAATTRKPESNAVTKTAGPIASAQKQPAGKV 502
Cdd:PHA03378  810 MPRAAPGQQ---GPTKQILRQLLTGGVK-----RGRPSLKKPAALERQAAAGPTPSPGSGTSDKI 866
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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