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Conserved domains on  [gi|1863909978|ref|NP_001371861|]
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leucine-rich repeat and death domain-containing protein 1 isoform 2 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-99 8.72e-16

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.50  E-value: 8.72e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863909978   1 MTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDD 80
Cdd:COG4886   135 LTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSG 214

                          90
                  ....*....|....*....
gi 1863909978  81 NPLLRPPVEICKGKQLYTI 99
Cdd:COG4886   215 NQLTDLPEPLANLTNLETL 233
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-99 8.72e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.50  E-value: 8.72e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863909978   1 MTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDD 80
Cdd:COG4886   135 LTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSG 214

                          90
                  ....*....|....*....
gi 1863909978  81 NPLLRPPVEICKGKQLYTI 99
Cdd:COG4886   215 NQLTDLPEPLANLTNLETL 233
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 11-83 8.63e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 48.69  E-value: 8.63e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1863909978  11 NNAIREIPRNIGELRNLVSLH-AYNNQISYLPPSLLSLNDLQQLNLSGNNLTA-LPSAIYNIFSLKEINFDDNPL 83
Cdd:PLN00113  222 NNLSGEIPYEIGGLTSLNHLDlVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGpIPPSIFSLQKLISLDLSDNSL 296
LRR_8 pfam13855
Leucine rich repeat;
2-60 1.33e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 1.33e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1863909978   2 TQLKELDISNNAIREI-PRNIGELRNLVSLHAYNNQISYLPP-SLLSLNDLQQLNLSGNNL 60
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPgAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 2-87 2.53e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.61  E-value: 2.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863909978   2 TQLKELDISNNAIRE------IPRNIGELRN-LVSLHAYNNQISYLPPsLLSLNDLQQLNLSGNNLT---ALPSAIYNIF 71
Cdd:cd21340    90 TNLEELHIENQRLPPgekltfDPRSLAALSNsLRVLNISGNNIDSLEP-LAPLRNLEQLDASNNQISdleELLDLLSSWP 168

                          90
                  ....*....|....*.
gi 1863909978  72 SLKEINFDDNPLLRPP 87
Cdd:cd21340   169 SLRELDLTGNPVCKKP 184
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-99 8.72e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.50  E-value: 8.72e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863909978   1 MTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDD 80
Cdd:COG4886   135 LTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSG 214

                          90
                  ....*....|....*....
gi 1863909978  81 NPLLRPPVEICKGKQLYTI 99
Cdd:COG4886   215 NQLTDLPEPLANLTNLETL 233
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-96 1.73e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 70.73  E-value: 1.73e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863909978   1 MTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDD 80
Cdd:COG4886   112 LTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSN 191

                          90
                  ....*....|....*.
gi 1863909978  81 NPLLRPPVEICKGKQL 96
Cdd:COG4886   192 NQITDLPEPLGNLTNL 207
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-83 8.30e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.81  E-value: 8.30e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863909978   1 MTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDD 80
Cdd:COG4886   158 LTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSN 237


                  ...
gi 1863909978  81 NPL 83
Cdd:COG4886   238 NQL 240
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-83 1.38e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 65.34  E-value: 1.38e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863909978   1 MTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSaIYNIFSLKEINFDD 80
Cdd:COG4886   181 LTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE-LGNLTNLEELDLSN 259


                  ...
gi 1863909978  81 NPL 83
Cdd:COG4886   260 NQL 262
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-83 7.20e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 60.33  E-value: 7.20e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863909978   1 MTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPpSLLSLNDLQQLNLSGNNLTALPSaIYNIFSLKEINFDD 80
Cdd:COG4886   204 LTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSN 281


                  ...
gi 1863909978  81 NPL 83
Cdd:COG4886   282 NQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-96 1.04e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 54.17  E-value: 1.04e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863909978   1 MTQLKELDISNNaireipRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDD 80
Cdd:COG4886    95 LTNLTELDLSGN------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSN 168

                          90
                  ....*....|....*.
gi 1863909978  81 NPLLRPPVEICKGKQL 96
Cdd:COG4886   169 NQLTDLPEELGNLTNL 184
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 11-83 8.63e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 48.69  E-value: 8.63e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1863909978  11 NNAIREIPRNIGELRNLVSLH-AYNNQISYLPPSLLSLNDLQQLNLSGNNLTA-LPSAIYNIFSLKEINFDDNPL 83
Cdd:PLN00113  222 NNLSGEIPYEIGGLTSLNHLDlVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGpIPPSIFSLQKLISLDLSDNSL 296
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-63 2.41e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 47.62  E-value: 2.41e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1863909978   1 MTQLKELDISNNAIREIPrNIGELRNLVSLHAYNNQISYLPPsLLSLNDLQQLNLSGNNLTAL 63
Cdd:COG4886   227 LTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQLTDL 287
PLN03150 PLN03150
hypothetical protein; Provisional
 3-84 4.25e-07

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 46.73  E-value: 4.25e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863909978   3 QLKELDISNNAIR-EIPRNIGELRNLVSLH-AYNNQISYLPPSLLSLNDLQQLNLSGNNLTA-LPSAI-YNIFSLKEINF 78
Cdd:PLN03150  443 HLQSINLSGNSIRgNIPPSLGSITSLEVLDlSYNSFNGSIPESLGQLTSLRILNLNGNSLSGrVPAALgGRLLHRASFNF 522


                  ....*.
gi 1863909978  79 DDNPLL 84
Cdd:PLN03150  523 TDNAGL 528
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
2-87 4.37e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 47.00  E-value: 4.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863909978   2 TQLKELDISNNAIREIPRNIGElrNLVSLHAYNNQISYLPPSLLSlnDLQQLNLSGNNLTALPSAIynIFSLKEINFDDN 81
Cdd:PRK15370  262 SALQSLDLFHNKISCLPENLPE--ELRYLSVYDNSIRTLPAHLPS--GITHLNVQSNSLTALPETL--PPGLKTLEAGEN 335


                  ....*.
gi 1863909978  82 PLLRPP 87
Cdd:PRK15370  336 ALTSLP 341
PLN03150 PLN03150
hypothetical protein; Provisional
 7-83 3.87e-06

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 44.04  E-value: 3.87e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863909978   7 LDISNNAIR-EIPRNIGELRNLVSLHAYNNQI-SYLPPSLLSLNDLQQLNLSGNNLT-ALPSAIYNIFSLKEINFDDNPL 83
Cdd:PLN03150  423 LGLDNQGLRgFIPNDISKLRHLQSINLSGNSIrGNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSL 502
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 1-83 8.20e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 43.30  E-value: 8.20e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863909978   1 MTQLKELDISNNAIR-EIPRNIGELRNLVSLHAYNNQIS-YLPPSLLSLNDLQQLNLSGNNLTA-LPSAIYNIFSLKEIN 77
Cdd:PLN00113  498 LSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLSGeIPKNLGNVESLVQVN 577


                  ....*.
gi 1863909978  78 FDDNPL 83
Cdd:PLN00113  578 ISHNHL 583
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 1-61 1.11e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.91  E-value: 1.11e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1863909978   1 MTQLKELD-ISNNAIREIPRNIGELRNLVSLHAYNNQIS-YLPPSLLSLNDLQQLNLSGNNLT 61
Cdd:PLN00113  235 LTSLNHLDlVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLS 297
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
4-77 2.20e-05

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 42.07  E-value: 2.20e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1863909978   4 LKELDISNNAIREIPRNIGELrnlVSLHAYNNQISYLP--PSllslnDLQQLNLSGNNLTALPSAIYNIFSLKEIN 77
Cdd:PRK15387  304 LQELSVSDNQLASLPALPSEL---CKLWAYNNQLTSLPtlPS-----GLQELSVSDNQLASLPTLPSELYKLWAYN 371
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
2-61 4.91e-05

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 40.92  E-value: 4.91e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863909978   2 TQLKELDISNNAIREIPRNIGelrNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLT 61
Cdd:PRK15387  402 SELKELMVSGNRLTSLPMLPS---GLLSLSVYRNQLTRLPESLIHLSSETTVNLEGNPLS 458
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
4-88 1.12e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 40.15  E-value: 1.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863909978   4 LKELDISNNAIREIPRNIGElrnLVSLHAYNNQISYLP--PSllslnDLQQLNLSGNNLTALPSAIYnifSLKEINFDDN 81
Cdd:PRK15387  344 LQELSVSDNQLASLPTLPSE---LYKLWAYNNRLTSLPalPS-----GLKELIVSGNRLTSLPVLPS---ELKELMVSGN 412


                  ....*..
gi 1863909978  82 PLLRPPV 88
Cdd:PRK15387  413 RLTSLPM 419
LRR_8 pfam13855
Leucine rich repeat;
2-60 1.33e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 1.33e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1863909978   2 TQLKELDISNNAIREI-PRNIGELRNLVSLHAYNNQISYLPP-SLLSLNDLQQLNLSGNNL 60
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPgAFSGLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
4-83 2.31e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 38.99  E-value: 2.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863909978   4 LKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNdlqqlnLSGNNLTALPSAIYNIFSLKEINFDDNPL 83
Cdd:PRK15387  384 LKELIVSGNRLTSLPVLPSELKELMVSGNRLTSLPMLPSGLLSLS------VYRNQLTRLPESLIHLSSETTVNLEGNPL 457
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 2-87 2.53e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.61  E-value: 2.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863909978   2 TQLKELDISNNAIRE------IPRNIGELRN-LVSLHAYNNQISYLPPsLLSLNDLQQLNLSGNNLT---ALPSAIYNIF 71
Cdd:cd21340    90 TNLEELHIENQRLPPgekltfDPRSLAALSNsLRVLNISGNNIDSLEP-LAPLRNLEQLDASNNQISdleELLDLLSSWP 168

                          90
                  ....*....|....*.
gi 1863909978  72 SLKEINFDDNPLLRPP 87
Cdd:cd21340   169 SLRELDLTGNPVCKKP 184
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
2-99 5.06e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 37.99  E-value: 5.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863909978   2 TQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQisylppSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDN 81
Cdd:COG4886    73 LLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNN 146

                          90
                  ....*....|....*...
gi 1863909978  82 PLLRPPVEICKGKQLYTI 99
Cdd:COG4886   147 QLTDLPEPLGNLTNLKSL 164
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 2-61 6.67e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 37.46  E-value: 6.67e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863909978   2 TQLKELDISNNAIREIPrNIGELRNLVSLHAYNNQISYLPPsLLSLNDLQQLNLSGNNLT 61
Cdd:cd21340    24 KNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKIEN-LENLVNLKKLYLGGNRIS 81
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 1-83 7.14e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 37.07  E-value: 7.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863909978   1 MTQLKELDISNNAIREIPrNIGELRNLVSLHAYNNQISYL----------------------------PPSLLSL-NDLQ 51
Cdd:cd21340    45 LTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNRISVVeglenltnleelhienqrlppgekltfdPRSLAALsNSLR 123

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1863909978  52 QLNLSGNNLTALpSAIYNIFSLKEINFDDNPL 83
Cdd:cd21340   124 VLNISGNNIDSL-EPLAPLRNLEQLDASNNQI 154
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 4-83 1.09e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 37.13  E-value: 1.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863909978   4 LKELDISNNAIR-EIPRNIGELRNLVSLHAYNNQIS-YLPPSLLSLNDLQQLNLSGNNLTA-LPSAIYNIFSLKEINFDD 80
Cdd:PLN00113  142 LETLDLSNNMLSgEIPNDIGSFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQLVGqIPRELGQMKSLKWIYLGY 221


                  ...
gi 1863909978  81 NPL 83
Cdd:PLN00113  222 NNL 224
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 1-83 1.20e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 37.13  E-value: 1.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863909978   1 MTQLKELDIS-NNAIREIPRNIGElRNLVSLHAYNNQIS-YLPPSLLSLNDLQQLNLSGNNLTA-LPSAIYNIFSLKEIN 77
Cdd:PLN00113  451 MPSLQMLSLArNKFFGGLPDSFGS-KRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSGeIPDELSSCKKLVSLD 529


                  ....*.
gi 1863909978  78 FDDNPL 83
Cdd:PLN00113  530 LSHNQL 535
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 1-74 1.46e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 36.75  E-value: 1.46e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1863909978   1 MTQLKELDI-SNNAIREIPRNIGELRNLVSLH-AYNNQISYLPPSLLSLNDLQQLNLSGNNLTA-LPSAIYNIFSLK 74
Cdd:PLN00113  187 LTSLEFLTLaSNQLVGQIPRELGQMKSLKWIYlGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGpIPSSLGNLKNLQ 263
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 2-80 3.25e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 35.62  E-value: 3.25e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863909978    2 TQLKELDISNNAIREIPRNIgELRNLVSLHAYNNQ--------------ISYLPPSllslndLQQLNLSGN-NLTALPSA 66
Cdd:PLN03210   725 TNISWLDLDETAIEEFPSNL-RLENLDELILCEMKseklwervqpltplMTMLSPS------LTRLFLSDIpSLVELPSS 797

                           90
                   ....*....|....
gi 1863909978   67 IYNIFSLKEINFDD 80
Cdd:PLN03210   798 IQNLHKLEHLEIEN 811
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-81 8.88e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 34.52  E-value: 8.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863909978   1 MTQLKELDISNNAIREIPrNIGELRNLVSLHAYNNQISYLP----PSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEI 76
Cdd:COG4886   249 LTNLEELDLSNNQLTDLP-PLANLTNLKTLDLSNNQLTDLKlkelELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLL 327


                  ....*
gi 1863909978  77 NFDDN 81
Cdd:COG4886   328 LLLKG 332
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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