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Conserved domains on  [gi|1878348197|ref|NP_001372575|]
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zinc finger protein 273 isoform 3 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
94-440 3.28e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.86  E-value: 3.28e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1878348197  94 SNSNIHKKRQTGKKPFKC--KECGKSCCILSQLTQHKKTAT-RVNFYKCKTCGKAFNQFSNLTKHKIIHPEVNPYKCEEC 170
Cdd:COG5048    47 EHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHnNPSDLNSKSLPLSNSKASSSSLSSSSSNSNDNNLLSSH 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1878348197 171 GKAFNQSLTLTKHKKIHTEEKPYKCEDCGKVFSVF-----------------------SVLTKHKIIHTGTKPYNCEECG 227
Cdd:COG5048   127 SLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTpqsnslhpplpanslskdpssnlSLLISSNVSTSIPSSSENSPLS 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1878348197 228 KgFSIFSTLTKHKIIHTGEKPYKCNECGKAFNWSSTLTKHKRIHTGEKPYKCEECGKAFNQSSTLTRHKIVHTGE----- 302
Cdd:COG5048   207 S-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekg 285

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1878348197 303 --KPYKCEECGKAFKRSTTLTKHKRIYTKE----KPYKCEE--CGKAFSVFSTLTKHKIIHTGAKPYKC--EECGSAFRA 372
Cdd:COG5048   286 fsLPIKSKQCNISFSRSSPLTRHLRSVNHSgeslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSP 365

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1878348197 373 FST----LTEHKRVHTGEKPYKC---NECGKAFNWSSTLTKHKRIHTGEKPY--KCEECGKAFNRSSNLTRHKKIHT 440
Cdd:COG5048   366 LLNneppQSLQQYKDLKNDKKSEtlsNSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHT 442
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
94-440 3.28e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.86  E-value: 3.28e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1878348197  94 SNSNIHKKRQTGKKPFKC--KECGKSCCILSQLTQHKKTAT-RVNFYKCKTCGKAFNQFSNLTKHKIIHPEVNPYKCEEC 170
Cdd:COG5048    47 EHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHnNPSDLNSKSLPLSNSKASSSSLSSSSSNSNDNNLLSSH 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1878348197 171 GKAFNQSLTLTKHKKIHTEEKPYKCEDCGKVFSVF-----------------------SVLTKHKIIHTGTKPYNCEECG 227
Cdd:COG5048   127 SLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTpqsnslhpplpanslskdpssnlSLLISSNVSTSIPSSSENSPLS 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1878348197 228 KgFSIFSTLTKHKIIHTGEKPYKCNECGKAFNWSSTLTKHKRIHTGEKPYKCEECGKAFNQSSTLTRHKIVHTGE----- 302
Cdd:COG5048   207 S-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekg 285

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1878348197 303 --KPYKCEECGKAFKRSTTLTKHKRIYTKE----KPYKCEE--CGKAFSVFSTLTKHKIIHTGAKPYKC--EECGSAFRA 372
Cdd:COG5048   286 fsLPIKSKQCNISFSRSSPLTRHLRSVNHSgeslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSP 365

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1878348197 373 FST----LTEHKRVHTGEKPYKC---NECGKAFNWSSTLTKHKRIHTGEKPY--KCEECGKAFNRSSNLTRHKKIHT 440
Cdd:COG5048   366 LLNneppQSLQQYKDLKNDKKSEtlsNSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHT 442
zf-H2C2_2 pfam13465
Zinc-finger double domain;
264-288 3.46e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.46e-04
                          10        20
                  ....*....|....*....|....*
gi 1878348197 264 LTKHKRIHTGEKPYKCEECGKAFNQ 288
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
94-440 3.28e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.86  E-value: 3.28e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1878348197  94 SNSNIHKKRQTGKKPFKC--KECGKSCCILSQLTQHKKTAT-RVNFYKCKTCGKAFNQFSNLTKHKIIHPEVNPYKCEEC 170
Cdd:COG5048    47 EHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHnNPSDLNSKSLPLSNSKASSSSLSSSSSNSNDNNLLSSH 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1878348197 171 GKAFNQSLTLTKHKKIHTEEKPYKCEDCGKVFSVF-----------------------SVLTKHKIIHTGTKPYNCEECG 227
Cdd:COG5048   127 SLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTpqsnslhpplpanslskdpssnlSLLISSNVSTSIPSSSENSPLS 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1878348197 228 KgFSIFSTLTKHKIIHTGEKPYKCNECGKAFNWSSTLTKHKRIHTGEKPYKCEECGKAFNQSSTLTRHKIVHTGE----- 302
Cdd:COG5048   207 S-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekg 285

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1878348197 303 --KPYKCEECGKAFKRSTTLTKHKRIYTKE----KPYKCEE--CGKAFSVFSTLTKHKIIHTGAKPYKC--EECGSAFRA 372
Cdd:COG5048   286 fsLPIKSKQCNISFSRSSPLTRHLRSVNHSgeslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSP 365

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1878348197 373 FST----LTEHKRVHTGEKPYKC---NECGKAFNWSSTLTKHKRIHTGEKPY--KCEECGKAFNRSSNLTRHKKIHT 440
Cdd:COG5048   366 LLNneppQSLQQYKDLKNDKKSEtlsNSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
137-460 1.64e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.46  E-value: 1.64e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1878348197 137 YKCKTCGKAFNQFSNLTKHKIIHPEVNPYKCEECGKAFNQS--LTLTKHKKIHTEEKPYKCED-CGKVFSVFSVLTKHKI 213
Cdd:COG5048    34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNSKsLPLSNSKASSSSLSSS 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1878348197 214 IHTGTKPYNCEECGKGFSIFSTLTKHKIIHTGEKPYKCNECGKAFNWSSTLTKHKRIHTGEkpykcEECGKAFNQSSTLT 293
Cdd:COG5048   114 SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAN-----SLSKDPSSNLSLLI 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1878348197 294 RHKIVHTGEKPYKCEECGKAFKRSTTLTKHKRIYtKEKPYKCEECGKAFS-VFSTLTKHKIIHTGAKPYKCEECGSAF-R 371
Cdd:COG5048   189 SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLEN-SSSSLPLTTNSQLSPkSLLSQSPSSLSSSDSSSSASESPRSSLpT 267

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1878348197 372 AFSTLTEHKRVHTGE-----KPYKCNECGKAFNWSSTLTKHKR--IHTGE--KPYKCEE--CGKAFNRSSNLTRHKKIHT 440
Cdd:COG5048   268 ASSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHT 347

                         330       340
                  ....*....|....*....|
gi 1878348197 441 GEKPYKPKRCDSAFDNTPNF 460
Cdd:COG5048   348 SISPAKEKLLNSSSKFSPLL 367
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
275-437 1.89e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.08  E-value: 1.89e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1878348197 275 KPYKCEECGKAFNQSSTLTRHK--IVHTGE--KPYKCEE--CGKAFKRSTTLTKHKRIYTKEKPYKC--EECGKAFSVFS 346
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1878348197 347 T------LTKHKIIHTGAKPYKCE-ECGSAFRAFSTLTEHKRVHTGEKPY--KCNECGKAFNWSSTLTKHKRIHTGEKPY 417
Cdd:COG5048   368 NneppqsLQQYKDLKNDKKSETLSnSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                         170       180
                  ....*....|....*....|
gi 1878348197 418 KCEECGKaFNRSSNLTRHKK 437
Cdd:COG5048   448 LCSILKS-FRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
218-375 6.54e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 6.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1878348197 218 TKPYNCEECGKGFSIFSTLTKHK--IIHTGE--KPYKCNE--CGKAFNWSSTLTKHKRIHTGEKPYKC--EECGKAFNQS 289
Cdd:COG5048   287 SLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPL 366

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1878348197 290 STLTRHKIV--HTGEKPYKCEECGKAFKRSTTLTKHKRIYTKE-------KPYKCEECGKAFSVFSTLTKHKIIHTGAKP 360
Cdd:COG5048   367 LNNEPPQSLqqYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIIthlsfrpYNCKNPPCSKSFNRHYNLIPHKKIHTNHAP 446

                         170
                  ....*....|....*
gi 1878348197 361 YKCEECGSAFRAFST 375
Cdd:COG5048   447 LLCSILKSFRRDLDL 461
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
387-444 2.66e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.15  E-value: 2.66e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1878348197 387 KPYKCNECGKAFNWSSTLTKHKRIHTGEKPYKC--EECGKAFNRSSNLTRHKKIHTGEKP 444
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPS 91
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
129-296 3.45e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.76  E-value: 3.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1878348197 129 KTATRVNFYKCKTCGKAFNQFSNLTKHK--IIH--PEVNPYKCEE--CGKAFNQSLTLTKHKKIHTEEKPYKC--EDCGK 200
Cdd:COG5048   282 SEKGFSLPIKSKQCNISFSRSSPLTRHLrsVNHsgESLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSS 361

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1878348197 201 VFSVFSV-----LTKHKIIHTGTKPYNCE--ECGKGFSIFSTLTKHKIIHTGEKPY--KCNECGKAFNWSSTLTKHKRIH 271
Cdd:COG5048   362 KFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIH 441

                         170       180
                  ....*....|....*....|....*
gi 1878348197 272 TGEKPYKCEECGKAFNQSSTLTRHK 296
Cdd:COG5048   442 TNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
264-288 3.46e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.46e-04
                          10        20
                  ....*....|....*....|....*
gi 1878348197 264 LTKHKRIHTGEKPYKCEECGKAFNQ 288
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 245-328 3.52e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.78  E-value: 3.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1878348197 245 GEKPYKCN--ECGKAFNWSSTLTKHKrihtgekpyKCEECGKAFNQSSTLTRHKIVHTGEKPYKCEECGKAFKRSTTLTK 322
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1878348197 323 HKRIYT 328
Cdd:COG5189   417 HRKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
404-428 3.67e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.67e-04
                          10        20
                  ....*....|....*....|....*
gi 1878348197 404 LTKHKRIHTGEKPYKCEECGKAFNR 428
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 273-352 4.74e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 4.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1878348197 273 GEKPYKCE--ECGKAFNQSSTLTRHKivhtgekpyKCEECGKAFKRSTTLTKHKRIYTKEKPYKCEECGKAFSVFSTLTK 350
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 1878348197 351 HK 352
Cdd:COG5189   417 HR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 260-380 7.60e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 7.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1878348197 260 WSSTLTKHKRIHTGEKPYKCEECGKAFNQSSTLT----RHKIVHTGEKPYKCE--ECGKAFKRSTTLTKHKriytkekpy 333
Cdd:COG5189   301 IRGGISTGEMIDVRKLPCTNSSSNGKLAHGGERNidtpSRMLKVKDGKPYKCPveGCNKKYKNQNGLKYHM--------- 371

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1878348197 334 KCEECGKAFSVFSTLTKHKIIHTGAKPYKCEECGSAFRAFSTLTEHK 380
Cdd:COG5189   372 LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYHR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
292-316 8.29e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 8.29e-04
                          10        20
                  ....*....|....*....|....*
gi 1878348197 292 LTRHKIVHTGEKPYKCEECGKAFKR 316
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
275-328 1.10e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 1.10e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1878348197 275 KPYKCEECGKAFNQSSTLTRHKIVHTGEKPYKCEECGKAFKRSTTLTKHKRIYT 328
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRT 85
zf-H2C2_2 pfam13465
Zinc-finger double domain;
376-399 1.82e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.82e-03
                          10        20
                  ....*....|....*....|....
gi 1878348197 376 LTEHKRVHTGEKPYKCNECGKAFN 399
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
236-259 3.28e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.28e-03
                          10        20
                  ....*....|....*....|....
gi 1878348197 236 LTKHKIIHTGEKPYKCNECGKAFN 259
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 417-439 5.89e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 5.89e-03
                          10        20
                  ....*....|....*....|...
gi 1878348197 417 YKCEECGKAFNRSSNLTRHKKIH 439
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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