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Conserved domains on  [gi|1883543049|ref|NP_001372798|]
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protein FAM13B isoform 12 [Homo sapiens]

Protein Classification

RecQL4_SLD2_NTD superfamily-containing protein( domain architecture ID 1904008)

RecQL4_SLD2_NTD superfamily-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RecQL4_SLD2_NTD super family cl44467
N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA ...
 587-626 2.37e-03

N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins; RecQL4, also called ATP-dependent DNA helicase Q4, or DNA helicase, RecQ-like type 4 (RecQ4), or RTS, is a DNA-dependent ATPase that may modulate chromosome segregation. This family also includes fungal DNA replication regulator SLD2, also known as DNA replication and checkpoint protein 1 (DRC1), which functions with DPB11 to control DNA replication and the S-phase checkpoint. It is also required for the proper activation of RAD53 in response to DNA damage and replication blocks. This model corresponds to the N-terminal domain of RecQL4 and SLD2, which is a homeodomain-like DNA interaction motif.


The actual alignment was detected with superfamily member cd22289:

Pssm-ID: 412085  Cd Length: 49  Bit Score: 36.45  E-value: 2.37e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1883543049 587 KLRKTLREFEEAFYQQNGRNAQKEDRVPVLEE----YREYKKIK 626
Cdd:cd22289     5 ELKIALKTWERAFAKKHGRKPTKDDIKAAPEEikdlYKEYAKLK 48
 
Name Accession Description Interval E-value
RecQL4_SLD2_NTD cd22289
N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA ...
 587-626 2.37e-03

N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins; RecQL4, also called ATP-dependent DNA helicase Q4, or DNA helicase, RecQ-like type 4 (RecQ4), or RTS, is a DNA-dependent ATPase that may modulate chromosome segregation. This family also includes fungal DNA replication regulator SLD2, also known as DNA replication and checkpoint protein 1 (DRC1), which functions with DPB11 to control DNA replication and the S-phase checkpoint. It is also required for the proper activation of RAD53 in response to DNA damage and replication blocks. This model corresponds to the N-terminal domain of RecQL4 and SLD2, which is a homeodomain-like DNA interaction motif.


Pssm-ID: 412085  Cd Length: 49  Bit Score: 36.45  E-value: 2.37e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1883543049 587 KLRKTLREFEEAFYQQNGRNAQKEDRVPVLEE----YREYKKIK 626
Cdd:cd22289     5 ELKIALKTWERAFAKKHGRKPTKDDIKAAPEEikdlYKEYAKLK 48
 
Name Accession Description Interval E-value
RecQL4_SLD2_NTD cd22289
N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA ...
 587-626 2.37e-03

N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins; RecQL4, also called ATP-dependent DNA helicase Q4, or DNA helicase, RecQ-like type 4 (RecQ4), or RTS, is a DNA-dependent ATPase that may modulate chromosome segregation. This family also includes fungal DNA replication regulator SLD2, also known as DNA replication and checkpoint protein 1 (DRC1), which functions with DPB11 to control DNA replication and the S-phase checkpoint. It is also required for the proper activation of RAD53 in response to DNA damage and replication blocks. This model corresponds to the N-terminal domain of RecQL4 and SLD2, which is a homeodomain-like DNA interaction motif.


Pssm-ID: 412085  Cd Length: 49  Bit Score: 36.45  E-value: 2.37e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1883543049 587 KLRKTLREFEEAFYQQNGRNAQKEDRVPVLEE----YREYKKIK 626
Cdd:cd22289     5 ELKIALKTWERAFAKKHGRKPTKDDIKAAPEEikdlYKEYAKLK 48
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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