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Conserved domains on  [gi|1972235703|ref|NP_001379272|]
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Protein zer-1 homolog [Caenorhabditis elegans]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1001123)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions; similar to Oryctolagus cuniculus monocyte differentiation antigen CD14, a coreceptor for bacterial lipopolysaccharide

Gene Ontology:  GO:0005515
PubMed:  11751054

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR super family cl34836
Leucine-rich repeat (LRR) protein [Transcription];
150-277 8.38e-08

Leucine-rich repeat (LRR) protein [Transcription];


The actual alignment was detected with superfamily member COG4886:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 55.32  E-value: 8.38e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972235703 150 QLPWLRSLALCGLKFykTEFSKIFPSFVNLDCLDISYSNVSNL-QGISNLQNLRQLSLRGlefKRAQDLEELFTLKHLNV 228
Cdd:COG4886   180 NLTNLKELDLSNNQI--TDLPEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSN---NQLTDLPELGNLTNLEE 254

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1972235703 229 LDMSirlKNALQTnirvfLSCNKVLPELRFLDLSGNKMDEDQLEELLES 277
Cdd:COG4886   255 LDLS---NNQLTD-----LPPLANLTNLKTLDLSNNQLTDLKLKELELL 295
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
150-277 8.38e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 55.32  E-value: 8.38e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972235703 150 QLPWLRSLALCGLKFykTEFSKIFPSFVNLDCLDISYSNVSNL-QGISNLQNLRQLSLRGlefKRAQDLEELFTLKHLNV 228
Cdd:COG4886   180 NLTNLKELDLSNNQI--TDLPEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSN---NQLTDLPELGNLTNLEE 254

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1972235703 229 LDMSirlKNALQTnirvfLSCNKVLPELRFLDLSGNKMDEDQLEELLES 277
Cdd:COG4886   255 LDLS---NNQLTD-----LPPLANLTNLKTLDLSNNQLTDLKLKELELL 295
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 175-284 2.46e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.15  E-value: 2.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972235703 175 SFVNLDCLDISYSNVSNLQGISNLQNLRQLSL------RGLEFkrAQDLEELFTL-KHLNVLDMSirlKNALQTnirvfL 247
Cdd:cd21340    66 NLVNLKKLYLGGNRISVVEGLENLTNLEELHIenqrlpPGEKL--TFDPRSLAALsNSLRVLNIS---GNNIDS-----L 135

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1972235703 248 SCNKVLPELRFLDLSGNKMDE-DQLEELLESHSHLHKI 284
Cdd:cd21340   136 EPLAPLRNLEQLDASNNQISDlEELLDLLSSWPSLREL 173
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
150-277 8.38e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 55.32  E-value: 8.38e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972235703 150 QLPWLRSLALCGLKFykTEFSKIFPSFVNLDCLDISYSNVSNL-QGISNLQNLRQLSLRGlefKRAQDLEELFTLKHLNV 228
Cdd:COG4886   180 NLTNLKELDLSNNQI--TDLPEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSN---NQLTDLPELGNLTNLEE 254

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1972235703 229 LDMSirlKNALQTnirvfLSCNKVLPELRFLDLSGNKMDEDQLEELLES 277
Cdd:COG4886   255 LDLS---NNQLTD-----LPPLANLTNLKTLDLSNNQLTDLKLKELELL 295
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
149-292 4.96e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.55  E-value: 4.96e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972235703 149 QQLPWLRSLALCGLKFyktefskiFPSFVNLDCLDISYSNVSNL-QGISNLQNLRQLSLRGLEFKraqDL-EELFTLKHL 226
Cdd:COG4886    93 GDLTNLTELDLSGNEE--------LSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLT---DLpEPLGNLTNL 161

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1972235703 227 NVLDMSirlKNALqTNIRVFLSCnkvLPELRFLDLSGNKMDEdqLEELLESHSHLHKIAIYGCGVK 292
Cdd:COG4886   162 KSLDLS---NNQL-TDLPEELGN---LTNLKELDLSNNQITD--LPEPLGNLTNLEELDLSGNQLT 218
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 175-284 2.46e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.15  E-value: 2.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972235703 175 SFVNLDCLDISYSNVSNLQGISNLQNLRQLSL------RGLEFkrAQDLEELFTL-KHLNVLDMSirlKNALQTnirvfL 247
Cdd:cd21340    66 NLVNLKKLYLGGNRISVVEGLENLTNLEELHIenqrlpPGEKL--TFDPRSLAALsNSLRVLNIS---GNNIDS-----L 135

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1972235703 248 SCNKVLPELRFLDLSGNKMDE-DQLEELLESHSHLHKI 284
Cdd:cd21340   136 EPLAPLRNLEQLDASNNQISDlEELLDLLSSWPSLREL 173
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 182-232 8.71e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.23  E-value: 8.71e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1972235703 182 LDISYSNVSNLQGISNLQNLRQLSLRGLEFKRAQDLEELF-TLKHLNVLDMS 232
Cdd:cd21340   125 LNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDLLsSWPSLRELDLT 176
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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