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Conserved domains on  [gi|2181862516|ref|NP_001387191|]
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sulfotransferase 1A2 isoform 4 [Homo sapiens]

Protein Classification

sulfotransferase domain-containing protein( domain architecture ID 10464534)

sulfotransferase domain-containing protein such as mammalian sulfotransferases that utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as the sulfonate donor to catalyze the sulfate conjugation of a variety of substrates including catecholamines, phenolic drugs, neurotransmitters, heparan, and estrogen, among others

CATH:  3.40.50.300
EC:  2.8.2.-
Gene Ontology:  GO:0008146
PubMed:  9360604|31270211
SCOP:  4003933

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
38-213 1.78e-52

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 169.45  E-value: 1.78e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181862516  38 PDDLLISTYPKSGTTWVSQILDMIYQGGDLEKCHRAPIFM---RVPFLEFKVP----GIPSGMETLKNTPAPRLLKTHLP 110
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLFNnhnRSPFLEWYPGdtyfDVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181862516 111 LALLPQTLLDQKVK------------------------------------------------------------------ 124
Cdd:pfam00685  81 LHLLPKSLWDPNAKiiylvrnpkdvavsyyhffrmakllkapgtpfefvedflngkvncgsyfdhvkgwwklrppgnilf 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181862516 125 --------NPKREIQKILEFVGRSLPEETVDLMVEHTSFKEMKKNPMTNYTTVRREfmdhsISPFMRKGMAGDWKTTFTV 196
Cdd:pfam00685 161 lryedlkkDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKE-----VSPFFRKGLVGDWKNYFTP 235

                         250
                  ....*....|....*..
gi 2181862516 197 AQNERFDADYAKKMAGC 213
Cdd:pfam00685 236 EQAEKFDEIYQEKMKGT 252
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
38-213 1.78e-52

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 169.45  E-value: 1.78e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181862516  38 PDDLLISTYPKSGTTWVSQILDMIYQGGDLEKCHRAPIFM---RVPFLEFKVP----GIPSGMETLKNTPAPRLLKTHLP 110
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLFNnhnRSPFLEWYPGdtyfDVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181862516 111 LALLPQTLLDQKVK------------------------------------------------------------------ 124
Cdd:pfam00685  81 LHLLPKSLWDPNAKiiylvrnpkdvavsyyhffrmakllkapgtpfefvedflngkvncgsyfdhvkgwwklrppgnilf 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181862516 125 --------NPKREIQKILEFVGRSLPEETVDLMVEHTSFKEMKKNPMTNYTTVRREfmdhsISPFMRKGMAGDWKTTFTV 196
Cdd:pfam00685 161 lryedlkkDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKE-----VSPFFRKGLVGDWKNYFTP 235

                         250
                  ....*....|....*..
gi 2181862516 197 AQNERFDADYAKKMAGC 213
Cdd:pfam00685 236 EQAEKFDEIYQEKMKGT 252
PLN02164 PLN02164
sulfotransferase
 34-124 4.86e-09

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 55.31  E-value: 4.86e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181862516  34 FQARPDDLLISTYPKSGTTWVSQILDMIYQGGDLEKCHRaPIFMR-----VPFLEFKVPGIPSgMETLKNTPAPrLLKTH 108
Cdd:PLN02164   75 FQARPNDFLVCSYPKTGTTWLKALTFAIANRSRFDDSSN-PLLKRnphefVPYIEIDFPFFPS-VDVLKDKGNT-LFSTH 151

                          90
                  ....*....|....*.
gi 2181862516 109 LPLALLPQTLLDQKVK 124
Cdd:PLN02164  152 IPYGLLPDSVVKSGCK 167
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
38-213 1.78e-52

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 169.45  E-value: 1.78e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181862516  38 PDDLLISTYPKSGTTWVSQILDMIYQGGDLEKCHRAPIFM---RVPFLEFKVP----GIPSGMETLKNTPAPRLLKTHLP 110
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLFNnhnRSPFLEWYPGdtyfDVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181862516 111 LALLPQTLLDQKVK------------------------------------------------------------------ 124
Cdd:pfam00685  81 LHLLPKSLWDPNAKiiylvrnpkdvavsyyhffrmakllkapgtpfefvedflngkvncgsyfdhvkgwwklrppgnilf 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181862516 125 --------NPKREIQKILEFVGRSLPEETVDLMVEHTSFKEMKKNPMTNYTTVRREfmdhsISPFMRKGMAGDWKTTFTV 196
Cdd:pfam00685 161 lryedlkkDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKE-----VSPFFRKGLVGDWKNYFTP 235

                         250
                  ....*....|....*..
gi 2181862516 197 AQNERFDADYAKKMAGC 213
Cdd:pfam00685 236 EQAEKFDEIYQEKMKGT 252
PLN02164 PLN02164
sulfotransferase
 34-124 4.86e-09

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 55.31  E-value: 4.86e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181862516  34 FQARPDDLLISTYPKSGTTWVSQILDMIYQGGDLEKCHRaPIFMR-----VPFLEFKVPGIPSgMETLKNTPAPrLLKTH 108
Cdd:PLN02164   75 FQARPNDFLVCSYPKTGTTWLKALTFAIANRSRFDDSSN-PLLKRnphefVPYIEIDFPFFPS-VDVLKDKGNT-LFSTH 151

                          90
                  ....*....|....*.
gi 2181862516 109 LPLALLPQTLLDQKVK 124
Cdd:PLN02164  152 IPYGLLPDSVVKSGCK 167
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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