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Conserved domains on  [gi|2190479646|ref|NP_001388219|]
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nucleoporin Nup43 isoform 1 [Rattus norvegicus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 73-293 2.27e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 81.61  E-value: 2.27e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2190479646  73 HHGDVMDLQFF-DQERIVAASSTGCVTVFlhhpnnqtlSVSQQWPTAHY--HTGPGSpsyssapCTGIVCDNPEIVTVGE 149
Cdd:cd00200     8 HTGGVTCVAFSpDGKLLATGSGDGTIKVW---------DLETGELLRTLkgHTGPVR-------DVAASADGTYLASGSS 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2190479646 150 DGRINLFRVDHKEAVRTIdNADSSTLHAVTFLRTPEIVTVNSI-GQLKIWDFRqqgSEPCQIlSLTGDRVPLHCVDRHPD 228
Cdd:cd00200    72 DKTIRLWDLETGECVRTL-TGHTSYVSSVAFSPDGRILSSSSRdKTIKVWDVE---TGKCLT-TLRGHTDWVNSVAFSPD 146

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2190479646 229 QQhVVATGGQDGMLSIWDVRQGTmPVSLLKAHEAEMWEVHFHPSNpDHLFTCSEDGSLWHWDAST 293
Cdd:cd00200   147 GT-FVASSSQDGTIKLWDLRTGK-CVATLTGHTGEVNSVAFSPDG-EKLLSSSSDGTIKLWDLST 208
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 73-293 2.27e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 81.61  E-value: 2.27e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2190479646  73 HHGDVMDLQFF-DQERIVAASSTGCVTVFlhhpnnqtlSVSQQWPTAHY--HTGPGSpsyssapCTGIVCDNPEIVTVGE 149
Cdd:cd00200     8 HTGGVTCVAFSpDGKLLATGSGDGTIKVW---------DLETGELLRTLkgHTGPVR-------DVAASADGTYLASGSS 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2190479646 150 DGRINLFRVDHKEAVRTIdNADSSTLHAVTFLRTPEIVTVNSI-GQLKIWDFRqqgSEPCQIlSLTGDRVPLHCVDRHPD 228
Cdd:cd00200    72 DKTIRLWDLETGECVRTL-TGHTSYVSSVAFSPDGRILSSSSRdKTIKVWDVE---TGKCLT-TLRGHTDWVNSVAFSPD 146

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2190479646 229 QQhVVATGGQDGMLSIWDVRQGTmPVSLLKAHEAEMWEVHFHPSNpDHLFTCSEDGSLWHWDAST 293
Cdd:cd00200   147 GT-FVASSSQDGTIKLWDLRTGK-CVATLTGHTGEVNSVAFSPDG-EKLLSSSSDGTIKLWDLST 208
WD40 COG2319
WD40 repeat [General function prediction only];
31-293 2.33e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 79.96  E-value: 2.33e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2190479646  31 TFATGSWDNEencVSLWSIGefgnldsdggfegDHQLLCDIRHHGD-VMDLQF-FDQERIVAASSTGcvTVFLHHPNNQT 108
Cdd:COG2319   176 LLASGSDDGT---VRLWDLA-------------TGKLLRTLTGHTGaVRSVAFsPDGKLLASGSADG--TVRLWDLATGK 237

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2190479646 109 LsvsqQWPTAHYHTGPGSPSYSSapctgivcDNPEIVTVGEDGRINLFRVDHKEAVRTIDnADSSTLHAVTFlrTPE--- 185
Cdd:COG2319   238 L----LRTLTGHSGSVRSVAFSP--------DGRLLASGSADGTVRLWDLATGELLRTLT-GHSGGVNSVAF--SPDgkl 302

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2190479646 186 IVTVNSIGQLKIWDFrqqgSEPCQILSLTGDRVPLHCVDRHPDQQHVvATGGQDGMLSIWDVRQGTmPVSLLKAHEAEMW 265
Cdd:COG2319   303 LASGSDDGTVRLWDL----ATGKLLRTLTGHTGAVRSVAFSPDGKTL-ASGSDDGTVRLWDLATGE-LLRTLTGHTGAVT 376

                         250       260
                  ....*....|....*....|....*...
gi 2190479646 266 EVHFHPSNpDHLFTCSEDGSLWHWDAST 293
Cdd:COG2319   377 SVAFSPDG-RTLASGSADGTVRLWDLAT 403
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 233-289 8.55e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 44.69  E-value: 8.55e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2190479646 233 VATGGQDGMLSIWDVRQGTMpVSLLKAHEAEMWEVHFHPSNPDHLFTCSEDGSLWHW 289
Cdd:PLN00181  548 VASSNFEGVVQVWDVARSQL-VTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLW 603
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 253-290 5.00e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.60  E-value: 5.00e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2190479646  253 PVSLLKAHEAEMWEVHFHPSNpDHLFTCSEDGSLWHWD 290
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 73-293 2.27e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 81.61  E-value: 2.27e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2190479646  73 HHGDVMDLQFF-DQERIVAASSTGCVTVFlhhpnnqtlSVSQQWPTAHY--HTGPGSpsyssapCTGIVCDNPEIVTVGE 149
Cdd:cd00200     8 HTGGVTCVAFSpDGKLLATGSGDGTIKVW---------DLETGELLRTLkgHTGPVR-------DVAASADGTYLASGSS 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2190479646 150 DGRINLFRVDHKEAVRTIdNADSSTLHAVTFLRTPEIVTVNSI-GQLKIWDFRqqgSEPCQIlSLTGDRVPLHCVDRHPD 228
Cdd:cd00200    72 DKTIRLWDLETGECVRTL-TGHTSYVSSVAFSPDGRILSSSSRdKTIKVWDVE---TGKCLT-TLRGHTDWVNSVAFSPD 146

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2190479646 229 QQhVVATGGQDGMLSIWDVRQGTmPVSLLKAHEAEMWEVHFHPSNpDHLFTCSEDGSLWHWDAST 293
Cdd:cd00200   147 GT-FVASSSQDGTIKLWDLRTGK-CVATLTGHTGEVNSVAFSPDG-EKLLSSSSDGTIKLWDLST 208
WD40 COG2319
WD40 repeat [General function prediction only];
31-293 2.33e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 79.96  E-value: 2.33e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2190479646  31 TFATGSWDNEencVSLWSIGefgnldsdggfegDHQLLCDIRHHGD-VMDLQF-FDQERIVAASSTGcvTVFLHHPNNQT 108
Cdd:COG2319   176 LLASGSDDGT---VRLWDLA-------------TGKLLRTLTGHTGaVRSVAFsPDGKLLASGSADG--TVRLWDLATGK 237

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2190479646 109 LsvsqQWPTAHYHTGPGSPSYSSapctgivcDNPEIVTVGEDGRINLFRVDHKEAVRTIDnADSSTLHAVTFlrTPE--- 185
Cdd:COG2319   238 L----LRTLTGHSGSVRSVAFSP--------DGRLLASGSADGTVRLWDLATGELLRTLT-GHSGGVNSVAF--SPDgkl 302

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2190479646 186 IVTVNSIGQLKIWDFrqqgSEPCQILSLTGDRVPLHCVDRHPDQQHVvATGGQDGMLSIWDVRQGTmPVSLLKAHEAEMW 265
Cdd:COG2319   303 LASGSDDGTVRLWDL----ATGKLLRTLTGHTGAVRSVAFSPDGKTL-ASGSDDGTVRLWDLATGE-LLRTLTGHTGAVT 376

                         250       260
                  ....*....|....*....|....*...
gi 2190479646 266 EVHFHPSNpDHLFTCSEDGSLWHWDAST 293
Cdd:COG2319   377 SVAFSPDG-RTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
31-306 7.40e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 78.41  E-value: 7.40e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2190479646  31 TFATGSWDNEencVSLWSIGefgnldsdggfegDHQLLCDIRHHGD-VMDLQFF-DQERIVAASSTGcvTVFLHHPNN-- 106
Cdd:COG2319   134 TLASGSADGT---VRLWDLA-------------TGKLLRTLTGHSGaVTSVAFSpDGKLLASGSDDG--TVRLWDLATgk 195

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2190479646 107 --QTLSVSQQWPTahyhtgpgSPSYSSapctgivcDNPEIVTVGEDGRINLFRVDHKEAVRTIDnADSSTLHAVTFlrTP 184
Cdd:COG2319   196 llRTLTGHTGAVR--------SVAFSP--------DGKLLASGSADGTVRLWDLATGKLLRTLT-GHSGSVRSVAF--SP 256

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2190479646 185 E---IVTVNSIGQLKIWDFrqQGSEPcqILSLTGDRVPLHCVDRHPDQQHVvATGGQDGMLSIWDVRQGTmPVSLLKAHE 261
Cdd:COG2319   257 DgrlLASGSADGTVRLWDL--ATGEL--LRTLTGHSGGVNSVAFSPDGKLL-ASGSDDGTVRLWDLATGK-LLRTLTGHT 330

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 2190479646 262 AEMWEVHFHPsNPDHLFTCSEDGSLWHWDASTNAPEKSSLFHQGG 306
Cdd:COG2319   331 GAVRSVAFSP-DGKTLASGSDDGTVRLWDLATGELLRTLTGHTGA 374
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 29-290 1.69e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 67.36  E-value: 1.69e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2190479646  29 TETFATGSWDNeenCVSLWSIGefgnldsdggfegDHQLLCDIRHH-GDVMDLQFFDQERIVAASSTGCVTVFLHHPNNQ 107
Cdd:cd00200    63 GTYLASGSSDK---TIRLWDLE-------------TGECVRTLTGHtSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGK 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2190479646 108 TLSvsqqwpTAHYHTGPGSpsyssapCTGIVCDNPEIVTVGEDGRINLFRVDHKEAVRTIDnADSSTLHAVTFLRT-PEI 186
Cdd:cd00200   127 CLT------TLRGHTDWVN-------SVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLT-GHTGEVNSVAFSPDgEKL 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2190479646 187 VTVNSIGQLKIWDFRQQGsepcQILSLTGDRVPLHCVDRHPDQQHVVAtGGQDGMLSIWDVRQGTmPVSLLKAHEAEMWE 266
Cdd:cd00200   193 LSSSSDGTIKLWDLSTGK----CLGTLRGHENGVNSVAFSPDGYLLAS-GSEDGTIRVWDLRTGE-CVQTLSGHTNSVTS 266

                         250       260
                  ....*....|....*....|....
gi 2190479646 267 VHFHPSNPDhLFTCSEDGSLWHWD 290
Cdd:cd00200   267 LAWSPDGKR-LASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 140-305 3.06e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 66.59  E-value: 3.06e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2190479646 140 DNPEIVTVGEDGRINLFRVDHKEAVRTIDNADSSTLHAVTFLRTPEIVTVNSIGQLKIWDFRQqgsePCQILSLTGDRVP 219
Cdd:cd00200    20 DGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET----GECVRTLTGHTSY 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2190479646 220 LHCVDRHPDqQHVVATGGQDGMLSIWDVRQGTmPVSLLKAHEAEMWEVHFHPSNpDHLFTCSEDGSLWHWDASTNAPEKS 299
Cdd:cd00200    96 VSSVAFSPD-GRILSSSSRDKTIKVWDVETGK-CLTTLRGHTDWVNSVAFSPDG-TFVASSSQDGTIKLWDLRTGKCVAT 172


                  ....*.
gi 2190479646 300 SLFHQG 305
Cdd:cd00200   173 LTGHTG 178
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 213-331 1.73e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 51.95  E-value: 1.73e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2190479646 213 LTGDRVPLHCVDRHPDQQHVvATGGQDGMLSIWDVRQGTmPVSLLKAHEAEMWEVHFHPSNpDHLFTCSEDGSLWHWDAS 292
Cdd:cd00200     5 LKGHTGGVTCVAFSPDGKLL-ATGSGDGTIKVWDLETGE-LLRTLKGHTGPVRDVAASADG-TYLASGSSDKTIRLWDLE 81

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2190479646 293 TNAPeksslfhqggRSTFLSHSSNQASVHLSLVSSWLST 331
Cdd:cd00200    82 TGEC----------VRTLTGHTSYVSSVAFSPDGRILSS 110
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 233-289 8.55e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 44.69  E-value: 8.55e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2190479646 233 VATGGQDGMLSIWDVRQGTMpVSLLKAHEAEMWEVHFHPSNPDHLFTCSEDGSLWHW 289
Cdd:PLN00181  548 VASSNFEGVVQVWDVARSQL-VTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLW 603
WD40 COG2319
WD40 repeat [General function prediction only];
140-306 2.26e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.98  E-value: 2.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2190479646 140 DNPEIVTVGEDGRINLFRVDHKEAVRTIDNADSSTLHAVTFLRTPEIVTVNSIGQLKIWDFRQQGsepcQILSLTGDRVP 219
Cdd:COG2319     5 DGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGA----LLATLLGHTAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2190479646 220 LHCVDRHPDQQHVvATGGQDGMLSIWDVRQGTmPVSLLKAHEAEMWEVHFHPSNpDHLFTCSEDGSLWHWDASTNAPEKS 299
Cdd:COG2319    81 VLSVAFSPDGRLL-ASASADGTVRLWDLATGL-LLRTLTGHTGAVRSVAFSPDG-KTLASGSADGTVRLWDLATGKLLRT 157


                  ....*..
gi 2190479646 300 SLFHQGG 306
Cdd:COG2319   158 LTGHSGA 164
Nsa1_WDR74-like cd22850
Ribosome biogenesis protein Nsa1 and similar proteins; Ribosome biogenesis protein Nsa1 ...
 186-246 1.66e-03

Ribosome biogenesis protein Nsa1 and similar proteins; Ribosome biogenesis protein Nsa1 (Nop7-associated 1) from fungi and WDR74 (WD repeat-containing protein 74) from mammals and plants, are homologous essential factors for ribosome assembly. In cooperation with the assembly factor Rix7/NVL2, Nsa1/WDR74 participates in an early cleavage of the pre-rRNA processing pathway. Rix7/NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of Nsa1/WDR74 from nucleolar pre-60S particles. Nsa1/WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase Rix7/NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439302 [Multi-domain]  Cd Length: 333  Bit Score: 39.92  E-value: 1.66e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2190479646 186 IVTVNSIGQLKIWDFRQQGSEPCQILSLTGDRVPLHCVDRHPDQQHVVATGGQDGMLSIWD 246
Cdd:cd22850   102 LTCATKSGLLHIIDLEDSKKDSLEVKAPLTLPGFLSAFRVNPTDEGVFAYGGKENDLKLWD 162
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 253-290 5.00e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.60  E-value: 5.00e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2190479646  253 PVSLLKAHEAEMWEVHFHPSNpDHLFTCSEDGSLWHWD 290
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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