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Conserved domains on  [gi|2252308628|ref|NP_001395119|]
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uncharacterized protein LOC628147 isoform 2 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12017129)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 2.49e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 81.36  E-value: 2.49e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2252308628   3 LVTYDDVQVNFTQDEWALLDPSQKSLYKGVMLETYRNLTAIG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
157-571 8.53e-19

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 89.37  E-value: 8.53e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308628 157 KQYECNQCGKAFERRSHLQIHKRTHTGEKPYECNQ--CGKAFARSGVLQKHKRTHTGEKPYEC-KQCGKAFAVISTLQMH 233
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308628 234 KRTHTGAKPYECKQCGKAFAVIYTLQRHKQTHTGEKPYKCKQC-GKTFARSSHLRIHKRTHTGEKPYECKQCGKAFArsg 312
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLI--- 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308628 313 vlqeHKRTHTGEKPYECKQCGKAFAQSSHLRIHKRTHTGEKPYECNQCGKAFARSGDLQQHKRTHTGEKPYECKQCG--- 389
Cdd:COG5048   189 ----SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPrss 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308628 390 ---KAFAQSSHLRIHKRTHTG-EKPYECNQCGKAFARSDDLQKHKRT--HTGE--KPYEC--KQCGKAFAHSSHLHKHER 459
Cdd:COG5048   265 lptASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHIL 344

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308628 460 THTGDKPYEC--NQCGKAF-----AESSTLQIHNRTHTGDKPYEC--NQCGKAFAVISTLQMHNRTHTGEKP--YKCKQC 528
Cdd:COG5048   345 LHTSISPAKEklLNSSSKFspllnNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPC 424

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 2252308628 529 GKAFAQSSHLRIHKRTHTGEKPYECKQCGKAFAQSSHLRIHKQ 571
Cdd:COG5048   425 SKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
zf-H2C2_2 pfam13465
Zinc-finger double domain;
118-142 5.57e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.57e-03
                          10        20
                  ....*....|....*....|....*
gi 2252308628 118 LQIHKRTHTGEKPYDCKQCGKVFAR 142
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 2.49e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 81.36  E-value: 2.49e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2252308628   3 LVTYDDVQVNFTQDEWALLDPSQKSLYKGVMLETYRNLTAIG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
157-571 8.53e-19

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 89.37  E-value: 8.53e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308628 157 KQYECNQCGKAFERRSHLQIHKRTHTGEKPYECNQ--CGKAFARSGVLQKHKRTHTGEKPYEC-KQCGKAFAVISTLQMH 233
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308628 234 KRTHTGAKPYECKQCGKAFAVIYTLQRHKQTHTGEKPYKCKQC-GKTFARSSHLRIHKRTHTGEKPYECKQCGKAFArsg 312
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLI--- 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308628 313 vlqeHKRTHTGEKPYECKQCGKAFAQSSHLRIHKRTHTGEKPYECNQCGKAFARSGDLQQHKRTHTGEKPYECKQCG--- 389
Cdd:COG5048   189 ----SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPrss 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308628 390 ---KAFAQSSHLRIHKRTHTG-EKPYECNQCGKAFARSDDLQKHKRT--HTGE--KPYEC--KQCGKAFAHSSHLHKHER 459
Cdd:COG5048   265 lptASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHIL 344

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308628 460 THTGDKPYEC--NQCGKAF-----AESSTLQIHNRTHTGDKPYEC--NQCGKAFAVISTLQMHNRTHTGEKP--YKCKQC 528
Cdd:COG5048   345 LHTSISPAKEklLNSSSKFspllnNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPC 424

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 2252308628 529 GKAFAQSSHLRIHKRTHTGEKPYECKQCGKAFAQSSHLRIHKQ 571
Cdd:COG5048   425 SKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
KRAB smart00349
krueppel associated box;
4-45 2.63e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 76.09  E-value: 2.63e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2252308628    4 VTYDDVQVNFTQDEWALLDPSQKSLYKGVMLETYRNLTAIGY 45
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-41 5.95e-15

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 68.73  E-value: 5.95e-15
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2252308628   4 VTYDDVQVNFTQDEWALLDPSQKSLYKGVMLETYRNLT 41
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
zf-H2C2_2 pfam13465
Zinc-finger double domain;
369-394 2.04e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.04e-04
                          10        20
                  ....*....|....*....|....*.
gi 2252308628 369 DLQQHKRTHTGEKPYECKQCGKAFAQ 394
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
118-142 5.57e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.57e-03
                          10        20
                  ....*....|....*....|....*
gi 2252308628 118 LQIHKRTHTGEKPYDCKQCGKVFAR 142
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 2.49e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 81.36  E-value: 2.49e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2252308628   3 LVTYDDVQVNFTQDEWALLDPSQKSLYKGVMLETYRNLTAIG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
157-571 8.53e-19

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 89.37  E-value: 8.53e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308628 157 KQYECNQCGKAFERRSHLQIHKRTHTGEKPYECNQ--CGKAFARSGVLQKHKRTHTGEKPYEC-KQCGKAFAVISTLQMH 233
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308628 234 KRTHTGAKPYECKQCGKAFAVIYTLQRHKQTHTGEKPYKCKQC-GKTFARSSHLRIHKRTHTGEKPYECKQCGKAFArsg 312
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLI--- 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308628 313 vlqeHKRTHTGEKPYECKQCGKAFAQSSHLRIHKRTHTGEKPYECNQCGKAFARSGDLQQHKRTHTGEKPYECKQCG--- 389
Cdd:COG5048   189 ----SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPrss 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308628 390 ---KAFAQSSHLRIHKRTHTG-EKPYECNQCGKAFARSDDLQKHKRT--HTGE--KPYEC--KQCGKAFAHSSHLHKHER 459
Cdd:COG5048   265 lptASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHIL 344

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308628 460 THTGDKPYEC--NQCGKAF-----AESSTLQIHNRTHTGDKPYEC--NQCGKAFAVISTLQMHNRTHTGEKP--YKCKQC 528
Cdd:COG5048   345 LHTSISPAKEklLNSSSKFspllnNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPC 424

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 2252308628 529 GKAFAQSSHLRIHKRTHTGEKPYECKQCGKAFAQSSHLRIHKQ 571
Cdd:COG5048   425 SKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
KRAB smart00349
krueppel associated box;
4-45 2.63e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 76.09  E-value: 2.63e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2252308628    4 VTYDDVQVNFTQDEWALLDPSQKSLYKGVMLETYRNLTAIGY 45
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-41 5.95e-15

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 68.73  E-value: 5.95e-15
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2252308628   4 VTYDDVQVNFTQDEWALLDPSQKSLYKGVMLETYRNLT 41
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
269-581 2.63e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.50  E-value: 2.63e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308628 269 KPYKCKQCGKTFARSSHLRIHKRTHTGEKPYEC--KQCGKAFARSGVLQEHKRTHTGEKPYEC-KQCGKAFAQSSHLRIH 345
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308628 346 KRTHTGEKPYECNQCGKAFARSGDLQQHKRTHTGEKPYECKQC---GKAFAQSSHLRIHKRTHtgekpyeCNQCGKAFAR 422
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnssSVNTPQSNSLHPPLPAN-------SLSKDPSSNL 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308628 423 SDDLqkHKRTHTGEKPYECKQCGKAFAHSSHLHKHERTHTGDKPYECNQCGKAFAESSTLQIHNRT------HTGDKPYE 496
Cdd:COG5048   185 SLLI--SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLsssdssSSASESPR 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308628 497 CNQCGKAFAVISTLQMHNRTHTG-EKPYKCKQCGKAFAQSSHLRIHKRT--HTGE--KPYEC--KQCGKAFAQSSHLRIH 569
Cdd:COG5048   263 SSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRH 342

                         330
                  ....*....|..
gi 2252308628 570 KQTHTGERPYEC 581
Cdd:COG5048   343 ILLHTSISPAKE 354
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
74-487 1.61e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 69.72  E-value: 1.61e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308628  74 PSDFIQCGKAFAYESGRQRHQIKHNGEKHHDCNQCGKD--FRTWNVLQIHKRTHTGEKPYDC-KQCGKVFARSCHLQIHN 150
Cdd:COG5048    33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLSS 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308628 151 QTHAGEKQYECNQCGKAFERRSHLQIHKRTHTGEKPYECNQC-GKAFARSGVLQKHKRTHTgekpyECKQCGKAFAVIST 229
Cdd:COG5048   113 SSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPA-----NSLSKDPSSNLSLL 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308628 230 LqmHKRTHTGAKPYECKQCGKAFAVIYTLQRHKQTHTGEKPYKCKQCG----KTFARSSHLRIHKRTHTGEKPYECKQCG 305
Cdd:COG5048   188 I--SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSqlspKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308628 306 --KAFARSGVLQEHKRTHTG-EKPYECKQCGKAFAQSSHLRIHKRT--HTGE--KPYEC--NQCGKAFARSGDLQQHKRT 376
Cdd:COG5048   266 ptASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILL 345

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308628 377 HTGEKPYECK--QCGKAFAQSSHLRIHKRTH-----TGEKPYEC--NQCGKAFARSDDLQKHKRTHTGEKPYECK--QCG 445
Cdd:COG5048   346 HTSISPAKEKllNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCS 425

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 2252308628 446 KAFAHSSHLHKHERTHTGDKPYECNQCGKaFAESSTLQIHNR 487
Cdd:COG5048   426 KSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
369-394 2.04e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.04e-04
                          10        20
                  ....*....|....*....|....*.
gi 2252308628 369 DLQQHKRTHTGEKPYECKQCGKAFAQ 394
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
425-450 2.63e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.63e-04
                          10        20
                  ....*....|....*....|....*.
gi 2252308628 425 DLQKHKRTHTGEKPYECKQCGKAFAH 450
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
314-338 3.53e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.53e-04
                          10        20
                  ....*....|....*....|....*
gi 2252308628 314 LQEHKRTHTGEKPYECKQCGKAFAQ 338
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
537-562 3.78e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.78e-04
                          10        20
                  ....*....|....*....|....*.
gi 2252308628 537 HLRIHKRTHTGEKPYECKQCGKAFAQ 562
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
285-310 3.97e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.97e-04
                          10        20
                  ....*....|....*....|....*.
gi 2252308628 285 HLRIHKRTHTGEKPYECKQCGKAFAR 310
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
258-282 4.33e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.33e-04
                          10        20
                  ....*....|....*....|....*
gi 2252308628 258 LQRHKQTHTGEKPYKCKQCGKTFAR 282
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
341-366 5.43e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.43e-04
                          10        20
                  ....*....|....*....|....*.
gi 2252308628 341 HLRIHKRTHTGEKPYECNQCGKAFAR 366
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
397-422 5.43e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.43e-04
                          10        20
                  ....*....|....*....|....*.
gi 2252308628 397 HLRIHKRTHTGEKPYECNQCGKAFAR 422
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
173-198 6.17e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.17e-04
                          10        20
                  ....*....|....*....|....*.
gi 2252308628 173 HLQIHKRTHTGEKPYECNQCGKAFAR 198
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
202-225 6.17e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.17e-04
                          10        20
                  ....*....|....*....|....
gi 2252308628 202 LQKHKRTHTGEKPYECKQCGKAFA 225
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
510-534 8.28e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 8.28e-04
                          10        20
                  ....*....|....*....|....*
gi 2252308628 510 LQMHNRTHTGEKPYKCKQCGKAFAQ 534
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
118-142 5.57e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.57e-03
                          10        20
                  ....*....|....*....|....*
gi 2252308628 118 LQIHKRTHTGEKPYDCKQCGKVFAR 142
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
230-253 5.91e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.91e-03
                          10        20
                  ....*....|....*....|....
gi 2252308628 230 LQMHKRTHTGAKPYECKQCGKAFA 253
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 271-293 7.44e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 7.44e-03
                          10        20
                  ....*....|....*....|...
gi 2252308628 271 YKCKQCGKTFARSSHLRIHKRTH 293
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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