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Conserved domains on  [gi|2288045677|ref|NP_001397927|]
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transmembrane protein 138 isoform 4 [Homo sapiens]

Protein Classification

TMEM138 domain-containing protein( domain architecture ID 10633085)

TMEM138 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TMEM138 pfam14935
Transmembrane protein 138; This family of proteins is found in eukaryotes and members are ...
 38-126 1.26e-34

Transmembrane protein 138; This family of proteins is found in eukaryotes and members are approximately 160 amino acids in length. There are two conserved sequence motifs: YYY and DPR. This transmembrane protein belongs to a family found in eukaryotes and is involved in the biogenesis and degradation of ciliated cells. Mutations in this protein cause the disease Joubert syndrome(JBTS) where the cilia becomes non-motile. Ciliopathy can be severe since cilia provide the cell with large amounts of information through signals. Ciliopathy can affect cell behaviour as the appropriate signals between the cell and its environment are not made, which can affect cell survival.


:

Pssm-ID: 434328  Cd Length: 119  Bit Score: 116.19  E-value: 1.26e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2288045677  38 QLVLFIIQDIAVLFNIIIIFLMFFNTFVFQAGLVNLLFHKFKGTIILTAVYFALSISLHVWVMNLRWKNSNSFIWTDGLQ 117
Cdd:pfam14935   1 LLVLFIIQDVCLILSLIVLLLSFFSTYVFQAGLVHLLLRKFRLTLITSVLYFILSISLHVWTLNLRWNNPNVFIWPDGLQ 80


                  ....*....
gi 2288045677 118 MLFVFQRLV 126
Cdd:pfam14935  81 ALFVLQRLV 89
 
Name Accession Description Interval E-value
TMEM138 pfam14935
Transmembrane protein 138; This family of proteins is found in eukaryotes and members are ...
 38-126 1.26e-34

Transmembrane protein 138; This family of proteins is found in eukaryotes and members are approximately 160 amino acids in length. There are two conserved sequence motifs: YYY and DPR. This transmembrane protein belongs to a family found in eukaryotes and is involved in the biogenesis and degradation of ciliated cells. Mutations in this protein cause the disease Joubert syndrome(JBTS) where the cilia becomes non-motile. Ciliopathy can be severe since cilia provide the cell with large amounts of information through signals. Ciliopathy can affect cell behaviour as the appropriate signals between the cell and its environment are not made, which can affect cell survival.


Pssm-ID: 434328  Cd Length: 119  Bit Score: 116.19  E-value: 1.26e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2288045677  38 QLVLFIIQDIAVLFNIIIIFLMFFNTFVFQAGLVNLLFHKFKGTIILTAVYFALSISLHVWVMNLRWKNSNSFIWTDGLQ 117
Cdd:pfam14935   1 LLVLFIIQDVCLILSLIVLLLSFFSTYVFQAGLVHLLLRKFRLTLITSVLYFILSISLHVWTLNLRWNNPNVFIWPDGLQ 80


                  ....*....
gi 2288045677 118 MLFVFQRLV 126
Cdd:pfam14935  81 ALFVLQRLV 89
 
Name Accession Description Interval E-value
TMEM138 pfam14935
Transmembrane protein 138; This family of proteins is found in eukaryotes and members are ...
 38-126 1.26e-34

Transmembrane protein 138; This family of proteins is found in eukaryotes and members are approximately 160 amino acids in length. There are two conserved sequence motifs: YYY and DPR. This transmembrane protein belongs to a family found in eukaryotes and is involved in the biogenesis and degradation of ciliated cells. Mutations in this protein cause the disease Joubert syndrome(JBTS) where the cilia becomes non-motile. Ciliopathy can be severe since cilia provide the cell with large amounts of information through signals. Ciliopathy can affect cell behaviour as the appropriate signals between the cell and its environment are not made, which can affect cell survival.


Pssm-ID: 434328  Cd Length: 119  Bit Score: 116.19  E-value: 1.26e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2288045677  38 QLVLFIIQDIAVLFNIIIIFLMFFNTFVFQAGLVNLLFHKFKGTIILTAVYFALSISLHVWVMNLRWKNSNSFIWTDGLQ 117
Cdd:pfam14935   1 LLVLFIIQDVCLILSLIVLLLSFFSTYVFQAGLVHLLLRKFRLTLITSVLYFILSISLHVWTLNLRWNNPNVFIWPDGLQ 80


                  ....*....
gi 2288045677 118 MLFVFQRLV 126
Cdd:pfam14935  81 ALFVLQRLV 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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