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Conserved domains on  [gi|2393919832|ref|NP_001401635|]
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transmembrane reductase CYB561D2 isoform 1 [Homo sapiens]

Protein Classification

cytochrome b561 domain-containing protein( domain architecture ID 10171790)

cytochrome b561 domain-containing protein (CYB561D) similar to mammalian CYB561D2, also called transmembrane ascorbate ferrireductase, a two-heme-containing cytochrome that catalyzes ascorbate-dependent trans-membrane ferric-chelate reduction

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cyt_b561_CYB561D2_like cd08761
Eukaryotic cytochrome b(561), including the CYB561D2 gene product; Cytochrome b(561), as found ...
 25-205 3.42e-41

Eukaryotic cytochrome b(561), including the CYB561D2 gene product; Cytochrome b(561), as found in eukaryotes, similar to and including the human CYB561D2 gene product. CYB561D2 is a candidate tumor suppressor. The protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


:

Pssm-ID: 176491  Cd Length: 183  Bit Score: 138.58  E-value: 3.42e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2393919832  25 LVALGFTIFVAVLARPGSSLFSWHPVLMSLAFSFLMTEALLVFSPESSLLHsLSRKGRARCHWVLQLLALLCALLGLGLV 104
Cdd:cd08761     1 LVAVVFAAFLLYIARPGTSLFSWHPLLMSLGFLLLMTEALLLLQPTSSLTK-LARKTKVRLHWILQLLALLCILAGLVAI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2393919832 105 ILHKEQLGKAHLVTRHGQAGLLAVLWAGLQCSGGVGLLYPKLLPR--WPLAKLKLYHATSGLVGYLLGSASLLLGMCSLW 182
Cdd:cd08761    80 YYNKERNGKPHFTSWHGILGLVTVILIVLQALGGLALLYPPGLRRgeSKAKKLKKYHRLSGYVAYLLGLATLVLGLETRW 159

                         170       180
                  ....*....|....*....|....
gi 2393919832 183 FTASVT-GAAWYLAVLCPVLTSLV 205
Cdd:cd08761   160 FSKNVThVALWYLALAVALALAGV 183
 
Name Accession Description Interval E-value
Cyt_b561_CYB561D2_like cd08761
Eukaryotic cytochrome b(561), including the CYB561D2 gene product; Cytochrome b(561), as found ...
 25-205 3.42e-41

Eukaryotic cytochrome b(561), including the CYB561D2 gene product; Cytochrome b(561), as found in eukaryotes, similar to and including the human CYB561D2 gene product. CYB561D2 is a candidate tumor suppressor. The protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176491  Cd Length: 183  Bit Score: 138.58  E-value: 3.42e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2393919832  25 LVALGFTIFVAVLARPGSSLFSWHPVLMSLAFSFLMTEALLVFSPESSLLHsLSRKGRARCHWVLQLLALLCALLGLGLV 104
Cdd:cd08761     1 LVAVVFAAFLLYIARPGTSLFSWHPLLMSLGFLLLMTEALLLLQPTSSLTK-LARKTKVRLHWILQLLALLCILAGLVAI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2393919832 105 ILHKEQLGKAHLVTRHGQAGLLAVLWAGLQCSGGVGLLYPKLLPR--WPLAKLKLYHATSGLVGYLLGSASLLLGMCSLW 182
Cdd:cd08761    80 YYNKERNGKPHFTSWHGILGLVTVILIVLQALGGLALLYPPGLRRgeSKAKKLKKYHRLSGYVAYLLGLATLVLGLETRW 159

                         170       180
                  ....*....|....*....|....
gi 2393919832 183 FTASVT-GAAWYLAVLCPVLTSLV 205
Cdd:cd08761   160 FSKNVThVALWYLALAVALALAGV 183
Cytochrom_B561 pfam03188
Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport ...
 47-184 1.43e-23

Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport protein. It is an integral membrane protein, that binds two heme groups non-covalently. This is a eukaryotic family. Members of the 'prokaryotic cytochrome b561' family can be found in Pfam: PF01292.


Pssm-ID: 427188  Cd Length: 137  Bit Score: 91.51  E-value: 1.43e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2393919832  47 WHPVLMSLAFSFLMTEALLVFSpeSSLLHSLSRKGRARCHWVLQLLALLCALLGLGLVILHKEQLGKAHLVTRHGQAGLL 126
Cdd:pfam03188   1 WHPVLMVIGFIFLMGEAILVYR--VNSTRRLSKKTKKLLHWILQALALILAVIGLVAVFKFHNLSGIPHFYSLHSWLGLL 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2393919832 127 AVLWAGLQCSGGVGLLYPKLLPRWPLAKLKLYHATSGLVGYLLGSASLLLGM-CSLWFT 184
Cdd:pfam03188  79 TVILYALQWVGGFVTFLFPGLSKRIRPLLLPLHVFFGLVIFVLAIVTALLGLlEKLIFQ 137
B561 smart00665
Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate ...
 47-167 4.19e-17

Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate for the generation of norepinephrine by dopamine-beta-hydroxylase in the chromaffin vesicles of the adrenal gland. It is a transmembrane heme protein with the two heme groups being bound to conserved histidine residues. A cytochrome b-561 homologue, termed Dcytb, is an iron-regulated ferric reductase in the duodenal mucosa. Other homologues of these are also likely to be ferric reductases. SDR2 is proposed to be important in regulating the metabolism of iron in the onset of neurodegenerative disorders.


Pssm-ID: 214769  Cd Length: 129  Bit Score: 74.58  E-value: 4.19e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2393919832   47 WHPVLMSLAFSFLMTEALLVFSPESSllhSLSRKGRARCHWVLQLLALLCALLGLGLVILHKEQLGKAHLVTRHGQAGLL 126
Cdd:smart00665   1 LHPVLMILGFGFLMGEAILVARPLTR---FLSKPTWFLLHVVLQILALVLGVIGLLAIFISHNESGIANFYSLHSWLGLA 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 2393919832  127 AVLWAGLQCSGGVGLLYPKLLPRWPLAKLKLYHATSGLVGY 167
Cdd:smart00665  78 AFVLAGLQWLSGFLRPLPPGLPSKYRSYLNPYHRFVGLAAF 118
 
Name Accession Description Interval E-value
Cyt_b561_CYB561D2_like cd08761
Eukaryotic cytochrome b(561), including the CYB561D2 gene product; Cytochrome b(561), as found ...
 25-205 3.42e-41

Eukaryotic cytochrome b(561), including the CYB561D2 gene product; Cytochrome b(561), as found in eukaryotes, similar to and including the human CYB561D2 gene product. CYB561D2 is a candidate tumor suppressor. The protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176491  Cd Length: 183  Bit Score: 138.58  E-value: 3.42e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2393919832  25 LVALGFTIFVAVLARPGSSLFSWHPVLMSLAFSFLMTEALLVFSPESSLLHsLSRKGRARCHWVLQLLALLCALLGLGLV 104
Cdd:cd08761     1 LVAVVFAAFLLYIARPGTSLFSWHPLLMSLGFLLLMTEALLLLQPTSSLTK-LARKTKVRLHWILQLLALLCILAGLVAI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2393919832 105 ILHKEQLGKAHLVTRHGQAGLLAVLWAGLQCSGGVGLLYPKLLPR--WPLAKLKLYHATSGLVGYLLGSASLLLGMCSLW 182
Cdd:cd08761    80 YYNKERNGKPHFTSWHGILGLVTVILIVLQALGGLALLYPPGLRRgeSKAKKLKKYHRLSGYVAYLLGLATLVLGLETRW 159

                         170       180
                  ....*....|....*....|....
gi 2393919832 183 FTASVT-GAAWYLAVLCPVLTSLV 205
Cdd:cd08761   160 FSKNVThVALWYLALAVALALAGV 183
Cytochrom_B561 pfam03188
Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport ...
 47-184 1.43e-23

Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport protein. It is an integral membrane protein, that binds two heme groups non-covalently. This is a eukaryotic family. Members of the 'prokaryotic cytochrome b561' family can be found in Pfam: PF01292.


Pssm-ID: 427188  Cd Length: 137  Bit Score: 91.51  E-value: 1.43e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2393919832  47 WHPVLMSLAFSFLMTEALLVFSpeSSLLHSLSRKGRARCHWVLQLLALLCALLGLGLVILHKEQLGKAHLVTRHGQAGLL 126
Cdd:pfam03188   1 WHPVLMVIGFIFLMGEAILVYR--VNSTRRLSKKTKKLLHWILQALALILAVIGLVAVFKFHNLSGIPHFYSLHSWLGLL 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2393919832 127 AVLWAGLQCSGGVGLLYPKLLPRWPLAKLKLYHATSGLVGYLLGSASLLLGM-CSLWFT 184
Cdd:pfam03188  79 TVILYALQWVGGFVTFLFPGLSKRIRPLLLPLHVFFGLVIFVLAIVTALLGLlEKLIFQ 137
B561 smart00665
Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate ...
 47-167 4.19e-17

Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate for the generation of norepinephrine by dopamine-beta-hydroxylase in the chromaffin vesicles of the adrenal gland. It is a transmembrane heme protein with the two heme groups being bound to conserved histidine residues. A cytochrome b-561 homologue, termed Dcytb, is an iron-regulated ferric reductase in the duodenal mucosa. Other homologues of these are also likely to be ferric reductases. SDR2 is proposed to be important in regulating the metabolism of iron in the onset of neurodegenerative disorders.


Pssm-ID: 214769  Cd Length: 129  Bit Score: 74.58  E-value: 4.19e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2393919832   47 WHPVLMSLAFSFLMTEALLVFSPESSllhSLSRKGRARCHWVLQLLALLCALLGLGLVILHKEQLGKAHLVTRHGQAGLL 126
Cdd:smart00665   1 LHPVLMILGFGFLMGEAILVARPLTR---FLSKPTWFLLHVVLQILALVLGVIGLLAIFISHNESGIANFYSLHSWLGLA 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 2393919832  127 AVLWAGLQCSGGVGLLYPKLLPRWPLAKLKLYHATSGLVGY 167
Cdd:smart00665  78 AFVLAGLQWLSGFLRPLPPGLPSKYRSYLNPYHRFVGLAAF 118
Cyt_b561 cd08554
Eukaryotic cytochrome b(561); Cytochrome b(561) is a family of endosomal or secretory ...
 45-167 2.01e-15

Eukaryotic cytochrome b(561); Cytochrome b(561) is a family of endosomal or secretory vesicle-specific electron transport proteins. They are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments. This is an exclusively eukaryotic family. Members of the prokaryotic cytochrome b561 family are not deemed homologous.


Pssm-ID: 176489  Cd Length: 131  Bit Score: 70.00  E-value: 2.01e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2393919832  45 FSWHPVLMSLAFSFLMTEALLVFSpessLLHSLSRKGRARCHWVLQLLALLCALLGLGLVILHKEQLGKAHLVTRHGQAG 124
Cdd:cd08554     2 FNWHPLLMVIGFVFLMGEALLVYR----VFRLLTKRALKLLHAILHLLAFVLGLVGLLAVFLFHNAGGIANLYSLHSWLG 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2393919832 125 LLAVLWAGLQCSGGVGLLYPKLLPRWPLAKLKLYHATSGLVGY 167
Cdd:cd08554    78 LATVLLFLLQFLSGFVLFLLPLLRLSYRSSLLPFHRFFGLAIF 120
Cyt_b561_CG1275_like cd08764
Non-vertebrate eumetazoan cytochrome b(561); Cytochrome b(561), as found in non-vertebrate ...
 25-167 2.25e-04

Non-vertebrate eumetazoan cytochrome b(561); Cytochrome b(561), as found in non-vertebrate eumetazoans, similar to the Drosophila melanogaster CG1275 gene product. This protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176494  Cd Length: 214  Bit Score: 40.78  E-value: 2.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2393919832  25 LVALGFTIFVAVLARPGSSL-FSWHPVLMSLAFSFLMTEALLVFSPESSllhslSRKGRARC-HWVLQLLALLCALLGLG 102
Cdd:cd08764     3 LVGIWLGKFRGGFSWTGPGLqFNWHPLLMVLGLIFLYGNSILVYRVFRN-----TRKKRLKLlHAVLHLLAFILAVIGLK 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2393919832 103 LVI--LHKEQLGKAHLVTRHGQAGLLAVLWAGLQCSGG-VGLLYPKlLPRWPLAKLKLYHATSGLVGY 167
Cdd:cd08764    78 AVFdsHNLAKPPIPNMYSLHSWLGLTAVILFSLQWVGGfVSFLFPG-LPETLRAAYLPLHVFFGLFIF 144
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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