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Conserved domains on  [gi|2416560123|ref|NP_001402069|]
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forkhead box protein O3 isoform 3 [Homo sapiens]

Protein Classification

FOXO_KIX_bdg and FOXO-TAD domain-containing protein( domain architecture ID 10891529)

protein containing domains FH, FOXO_KIX_bdg, and FOXO-TAD

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
FOXO_KIX_bdg pfam16675
KIX-binding domain of forkhead box O, CR2; FOXO_KIX_bd is the first part of the region of ...
243-322 2.81e-29

KIX-binding domain of forkhead box O, CR2; FOXO_KIX_bd is the first part of the region of transcription factor forkhead box O family proteins that binds to the CREB-binding proteins via the KIX domain. Coactivator CBP/p300 is recruited by FOXO3 via the binding of this domain as well as the simultaneous binding of the more C-terminal TAD domain.


:

Pssm-ID: 465228  Cd Length: 80  Bit Score: 109.82  E-value: 2.81e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416560123 243 STVFGPSSLNSLRQSPMQTIQENKPATFSSMSHYGN-QTLQDLLTSDSLSHSDVmMTQSDPLMSQASTAVSAQNSRRNVM 321
Cdd:pfam16675   1 KSIYGQPSMNSLRQMPMQTIQENKQSSFGSMSQYGPaGLLQELLTSDSYPHSDI-LTQVDPLMSQASGRVLSQNHRQNSV 79

                  .
gi 2416560123 322 L 322
Cdd:pfam16675  80 M 80
FH_FOX super family cl00061
Forkhead (FH) domain found in Forkhead box (FOX) family of transcription factors and similar ...
18-56 1.84e-19

Forkhead (FH) domain found in Forkhead box (FOX) family of transcription factors and similar proteins; The FOX family comprises diverse tissue- and cell type-specific transcription factors with an evolutionary conserved "Forkhead (FH)" or "winged helix" DNA-binding domain. FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. The structure of the FH domain contains 2 flexible loops or "wings" in the C-terminal region, hence the term winged helix. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'. They participate in a variety of cellular processes, such as cell cycle progression, proliferation, differentiation, migration, metabolism, and DNA damage response. Their expression can be regulated by multiple factors, and they can act as co-activators and/or transcriptional repressors. Fifty FOX-encoding genes in humans have been categorized into 19 subfamilies based on protein sequence homology (FOXA to FOXS).


The actual alignment was detected with superfamily member cd20063:

Pssm-ID: 469596 [Multi-domain]  Cd Length: 88  Bit Score: 82.79  E-value: 1.84e-19
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2416560123  18 QNSIRHNLSLHSRFMRVQNEGTGKSSWWIINPDGGKSGK 56
Cdd:cd20063    50 KNSIRHNLSLHTRFIRVQNEGTGKSSWWMLNPEGGKTGK 88
FOXO-TAD pfam16676
Transactivation domain of FOXO protein family; TAD is a promiscuous binding domain that ...
417-455 2.19e-19

Transactivation domain of FOXO protein family; TAD is a promiscuous binding domain that mediates the association of the transcription factor FOXO with the coactivator CBP/p300. Both this domain and the FOXO-KIX_bd family pfam16675 bind simultaneously the KIX domain of CBP/p300. Coactivator CBP/p300 is recruited by FOXO3 though binding to these two regions. The promiscuity of the TAD is further evidenced by that the finding that they also bind the TAZ1 and TAZ2 domains of CBP/p300.


:

Pssm-ID: 435506  Cd Length: 40  Bit Score: 81.23  E-value: 2.19e-19
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2416560123 417 KFPSDLDLDMFNGSLECDMESIIRSELMDADGLDFNFDS 455
Cdd:pfam16676   1 RLPSDLDLDMFQGSLECDVDSIIRNDLMDGDGLDFNFDS 39
 
Name Accession Description Interval E-value
FOXO_KIX_bdg pfam16675
KIX-binding domain of forkhead box O, CR2; FOXO_KIX_bd is the first part of the region of ...
243-322 2.81e-29

KIX-binding domain of forkhead box O, CR2; FOXO_KIX_bd is the first part of the region of transcription factor forkhead box O family proteins that binds to the CREB-binding proteins via the KIX domain. Coactivator CBP/p300 is recruited by FOXO3 via the binding of this domain as well as the simultaneous binding of the more C-terminal TAD domain.


Pssm-ID: 465228  Cd Length: 80  Bit Score: 109.82  E-value: 2.81e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416560123 243 STVFGPSSLNSLRQSPMQTIQENKPATFSSMSHYGN-QTLQDLLTSDSLSHSDVmMTQSDPLMSQASTAVSAQNSRRNVM 321
Cdd:pfam16675   1 KSIYGQPSMNSLRQMPMQTIQENKQSSFGSMSQYGPaGLLQELLTSDSYPHSDI-LTQVDPLMSQASGRVLSQNHRQNSV 79

                  .
gi 2416560123 322 L 322
Cdd:pfam16675  80 M 80
FH_FOXO6 cd20063
Forkhead (FH) domain found in Forkhead box protein O6 (FOXO6) and similar proteins; FOXO6 acts ...
18-56 1.84e-19

Forkhead (FH) domain found in Forkhead box protein O6 (FOXO6) and similar proteins; FOXO6 acts as a transcriptional activator that may play an important role on tumor invasion, metastasis and prognosis. The FH domain is a winged helix DNA-binding domain. All FOXOs bind to the consensus sequence 5'-GTAAACAA-3', known as the DAF-16 family member-binding element, which includes the core sequence 5'-(A/C)AA(C/T)A-3' recognized by all FOX family members.


Pssm-ID: 410837 [Multi-domain]  Cd Length: 88  Bit Score: 82.79  E-value: 1.84e-19
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2416560123  18 QNSIRHNLSLHSRFMRVQNEGTGKSSWWIINPDGGKSGK 56
Cdd:cd20063    50 KNSIRHNLSLHTRFIRVQNEGTGKSSWWMLNPEGGKTGK 88
FOXO-TAD pfam16676
Transactivation domain of FOXO protein family; TAD is a promiscuous binding domain that ...
417-455 2.19e-19

Transactivation domain of FOXO protein family; TAD is a promiscuous binding domain that mediates the association of the transcription factor FOXO with the coactivator CBP/p300. Both this domain and the FOXO-KIX_bd family pfam16675 bind simultaneously the KIX domain of CBP/p300. Coactivator CBP/p300 is recruited by FOXO3 though binding to these two regions. The promiscuity of the TAD is further evidenced by that the finding that they also bind the TAZ1 and TAZ2 domains of CBP/p300.


Pssm-ID: 435506  Cd Length: 40  Bit Score: 81.23  E-value: 2.19e-19
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2416560123 417 KFPSDLDLDMFNGSLECDMESIIRSELMDADGLDFNFDS 455
Cdd:pfam16676   1 RLPSDLDLDMFQGSLECDVDSIIRNDLMDGDGLDFNFDS 39
FH smart00339
FORKHEAD; FORKHEAD, also known as a "winged helix"
17-50 7.61e-13

FORKHEAD; FORKHEAD, also known as a "winged helix"


Pssm-ID: 214627 [Multi-domain]  Cd Length: 89  Bit Score: 64.18  E-value: 7.61e-13
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2416560123   17 KQNSIRHNLSLHSRFMRVQNEGT--GKSSWWIINPD 50
Cdd:smart00339  45 WQNSIRHNLSLNDCFVKVPREGDrpGKGSYWTLDPA 80
Forkhead pfam00250
Forkhead domain;
18-50 1.82e-08

Forkhead domain;


Pssm-ID: 459732  Cd Length: 86  Bit Score: 51.70  E-value: 1.82e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2416560123  18 QNSIRHNLSLHSRFMRV--QNEGTGKSSWWIINPD 50
Cdd:pfam00250  46 QNSIRHNLSLNKCFVKVprPKDEPGKGSYWTIDPE 80
 
Name Accession Description Interval E-value
FOXO_KIX_bdg pfam16675
KIX-binding domain of forkhead box O, CR2; FOXO_KIX_bd is the first part of the region of ...
243-322 2.81e-29

KIX-binding domain of forkhead box O, CR2; FOXO_KIX_bd is the first part of the region of transcription factor forkhead box O family proteins that binds to the CREB-binding proteins via the KIX domain. Coactivator CBP/p300 is recruited by FOXO3 via the binding of this domain as well as the simultaneous binding of the more C-terminal TAD domain.


Pssm-ID: 465228  Cd Length: 80  Bit Score: 109.82  E-value: 2.81e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2416560123 243 STVFGPSSLNSLRQSPMQTIQENKPATFSSMSHYGN-QTLQDLLTSDSLSHSDVmMTQSDPLMSQASTAVSAQNSRRNVM 321
Cdd:pfam16675   1 KSIYGQPSMNSLRQMPMQTIQENKQSSFGSMSQYGPaGLLQELLTSDSYPHSDI-LTQVDPLMSQASGRVLSQNHRQNSV 79

                  .
gi 2416560123 322 L 322
Cdd:pfam16675  80 M 80
FH_FOXO6 cd20063
Forkhead (FH) domain found in Forkhead box protein O6 (FOXO6) and similar proteins; FOXO6 acts ...
18-56 1.84e-19

Forkhead (FH) domain found in Forkhead box protein O6 (FOXO6) and similar proteins; FOXO6 acts as a transcriptional activator that may play an important role on tumor invasion, metastasis and prognosis. The FH domain is a winged helix DNA-binding domain. All FOXOs bind to the consensus sequence 5'-GTAAACAA-3', known as the DAF-16 family member-binding element, which includes the core sequence 5'-(A/C)AA(C/T)A-3' recognized by all FOX family members.


Pssm-ID: 410837 [Multi-domain]  Cd Length: 88  Bit Score: 82.79  E-value: 1.84e-19
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2416560123  18 QNSIRHNLSLHSRFMRVQNEGTGKSSWWIINPDGGKSGK 56
Cdd:cd20063    50 KNSIRHNLSLHTRFIRVQNEGTGKSSWWMLNPEGGKTGK 88
FOXO-TAD pfam16676
Transactivation domain of FOXO protein family; TAD is a promiscuous binding domain that ...
417-455 2.19e-19

Transactivation domain of FOXO protein family; TAD is a promiscuous binding domain that mediates the association of the transcription factor FOXO with the coactivator CBP/p300. Both this domain and the FOXO-KIX_bd family pfam16675 bind simultaneously the KIX domain of CBP/p300. Coactivator CBP/p300 is recruited by FOXO3 though binding to these two regions. The promiscuity of the TAD is further evidenced by that the finding that they also bind the TAZ1 and TAZ2 domains of CBP/p300.


Pssm-ID: 435506  Cd Length: 40  Bit Score: 81.23  E-value: 2.19e-19
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2416560123 417 KFPSDLDLDMFNGSLECDMESIIRSELMDADGLDFNFDS 455
Cdd:pfam16676   1 RLPSDLDLDMFQGSLECDVDSIIRNDLMDGDGLDFNFDS 39
FH_FOXO3 cd20061
Forkhead (FH) domain found in Forkhead box protein O3 (FOXO3); FOXO3, also called AF6q21 ...
18-50 5.22e-17

Forkhead (FH) domain found in Forkhead box protein O3 (FOXO3); FOXO3, also called AF6q21 protein or Forkhead in rhabdomyosarcoma-like 1 (FKHRL1), is a transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. It recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. The FH domain is a winged helix DNA-binding domain. All FOXOs bind to the consensus sequence 5'-GTAAACAA-3', known as the DAF-16 family member-binding element, which includes the core sequence 5'-(A/C)AA(C/T)A-3' recognized by all FOX family members.


Pssm-ID: 410835 [Multi-domain]  Cd Length: 83  Bit Score: 75.87  E-value: 5.22e-17
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2416560123  18 QNSIRHNLSLHSRFMRVQNEGTGKSSWWIINPD 50
Cdd:cd20061    51 KNSIRHNLSLHSRFIRVQNEGTGKSSWWMINPD 83
FH_FOXO1 cd20060
Forkhead (FH) domain found in Forkhead box protein O1 (FOXO1); FOXO1, also called Forkhead box ...
18-57 7.37e-17

Forkhead (FH) domain found in Forkhead box protein O1 (FOXO1); FOXO1, also called Forkhead box protein O1A or Forkhead in rhabdomyosarcoma (FKHR), is a transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. It binds to the insulin response element (IRE) with the consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with the consensus sequence 5'-TT[G/A]TTTAC-3'. The FH domain is a winged helix DNA-binding domain.


Pssm-ID: 410834 [Multi-domain]  Cd Length: 99  Bit Score: 76.04  E-value: 7.37e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2416560123  18 QNSIRHNLSLHSRFMRVQNEGTGKSSWWIINPDGGKSGKA 57
Cdd:cd20060    60 KNSIRHNLSLHSKFIRVQNEGTGKSSWWMLNPEGGKSGKS 99
FH_FOXO cd20032
Forkhead (FH) domain found in the Forkhead box protein O (FOXO) subfamily; The FOXO subfamily ...
18-48 1.88e-16

Forkhead (FH) domain found in the Forkhead box protein O (FOXO) subfamily; The FOXO subfamily includes several winged helix transcription factors: FOXO1, FOXO3, FOXO4 and FOXO6. FOXO transcription factors are involved in the regulation of longevity phenomenon via insulin and insulin-like growth factor signaling. All FOXOs bind to the consensus sequence 5'-GTAAACAA-3', known as the DAF-16 family member-binding element, which includes the core sequence 5'-(A/C)AA(C/T)A-3' recognized by all FOX family members. FOXO1, also called Forkhead box protein O1A or Forkhead in rhabdomyosarcoma (FKHR), is a transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. FOXO3, also called AF6q21 protein or Forkhead in rhabdomyosarcoma-like 1 (FKHRL1), is a transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. It recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. FOXO4, also called Fork head domain transcription factor AFX1, is a transcription factor involved in the regulation of the insulin signaling pathway. It binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. FOXO6 acts as a transcriptional activator that may play an important role on tumor invasion, metastasis, and prognosis. The FH domain is a winged helix DNA-binding domain.


Pssm-ID: 410806 [Multi-domain]  Cd Length: 80  Bit Score: 73.87  E-value: 1.88e-16
                          10        20        30
                  ....*....|....*....|....*....|.
gi 2416560123  18 QNSIRHNLSLHSRFMRVQNEGTGKSSWWIIN 48
Cdd:cd20032    50 KNSIRHNLSLHSRFVRVQNEGTGKSSWWTLN 80
FH_FOXO4 cd20062
Forkhead (FH) domain found in Forkhead box protein O4 (FOXO4) and similar proteins; FOXO4, ...
18-50 9.25e-14

Forkhead (FH) domain found in Forkhead box protein O4 (FOXO4) and similar proteins; FOXO4, also called Fork head domain transcription factor AFX1, is a transcription factor involved in the regulation of the insulin signaling pathway. It binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. The FH domain is a winged helix DNA-binding domain. All FOXOs bind to the consensus sequence 5'-GTAAACAA-3', known as the DAF-16 family member-binding element, which includes the core sequence 5'-(A/C)AA(C/T)A-3' recognized by all FOX family members.


Pssm-ID: 410836 [Multi-domain]  Cd Length: 86  Bit Score: 66.65  E-value: 9.25e-14
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2416560123  18 QNSIRHNLSLHSRFMRVQNEGTGKSSWWIINPD 50
Cdd:cd20062    54 KNSIRHNLSLHSKFIKVHNEATGKSSWWMLNPE 86
FH smart00339
FORKHEAD; FORKHEAD, also known as a "winged helix"
17-50 7.61e-13

FORKHEAD; FORKHEAD, also known as a "winged helix"


Pssm-ID: 214627 [Multi-domain]  Cd Length: 89  Bit Score: 64.18  E-value: 7.61e-13
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2416560123   17 KQNSIRHNLSLHSRFMRVQNEGT--GKSSWWIINPD 50
Cdd:smart00339  45 WQNSIRHNLSLNDCFVKVPREGDrpGKGSYWTLDPA 80
FH_FOX cd00059
Forkhead (FH) domain found in Forkhead box (FOX) family of transcription factors and similar ...
18-45 2.38e-10

Forkhead (FH) domain found in Forkhead box (FOX) family of transcription factors and similar proteins; The FOX family comprises diverse tissue- and cell type-specific transcription factors with an evolutionary conserved "Forkhead (FH)" or "winged helix" DNA-binding domain. FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. The structure of the FH domain contains 2 flexible loops or "wings" in the C-terminal region, hence the term winged helix. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'. They participate in a variety of cellular processes, such as cell cycle progression, proliferation, differentiation, migration, metabolism, and DNA damage response. Their expression can be regulated by multiple factors, and they can act as co-activators and/or transcriptional repressors. Fifty FOX-encoding genes in humans have been categorized into 19 subfamilies based on protein sequence homology (FOXA to FOXS).


Pssm-ID: 410788 [Multi-domain]  Cd Length: 75  Bit Score: 56.37  E-value: 2.38e-10
                          10        20        30
                  ....*....|....*....|....*....|
gi 2416560123  18 QNSIRHNLSLHSRFMRVQNEGT--GKSSWW 45
Cdd:cd00059    45 KNSIRHNLSLNKCFVKVPREPSdpGKGSYW 74
Forkhead pfam00250
Forkhead domain;
18-50 1.82e-08

Forkhead domain;


Pssm-ID: 459732  Cd Length: 86  Bit Score: 51.70  E-value: 1.82e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2416560123  18 QNSIRHNLSLHSRFMRV--QNEGTGKSSWWIINPD 50
Cdd:pfam00250  46 QNSIRHNLSLNKCFVKVprPKDEPGKGSYWTIDPE 80
FH_FOXQ2-like cd20035
Forkhead (FH) domain found in Forkhead box protein Q2 (FOXQ2) and similar proteins; FOXQ2 is ...
18-62 5.29e-08

Forkhead (FH) domain found in Forkhead box protein Q2 (FOXQ2) and similar proteins; FOXQ2 is the neurogenic ectoderm specification transcription factor that controls aboral development in cnidarians and anterior identity in bilaterians. It plays essential roles in epidermal development and central brain patterning. The foxQ2 gene is absent in placental mammals. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410809 [Multi-domain]  Cd Length: 95  Bit Score: 50.32  E-value: 5.29e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2416560123  18 QNSIRHNLSLHSRFMRVQNEGTGKSSWWIINPDGGKS---GKAPRRRA 62
Cdd:cd20035    46 KNSVRHNLSLNECFVKAGRAENGKGNYWTIHPACLEDfekGDFRRRRA 93
FH_FOXK cd20026
Forkhead (FH) domain found in the Forkhead box protein K (FOXK) subfamily; The FOXK subfamily ...
18-48 1.26e-06

Forkhead (FH) domain found in the Forkhead box protein K (FOXK) subfamily; The FOXK subfamily includes two winged helix transcription factors, FOXK1 and FOXK2. FOXK1, also called myocyte nuclear factor (MNF), acts as a transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin genes. It positively regulates Wnt/beta-catenin signaling by translocating dishevelled (DVL) proteins into the nucleus. It also reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression. In addition, FOXK1 plays important roles in multiple human cancers. FOXK2, also called cellular transcription factor ILF-1 or interleukin enhancer-binding factor 1, is a transcriptional regulator that recognizes the core sequence 5'-TAAACA-3'. It binds to NFAT-like motifs (purine-rich) in the IL2 promoter. It also binds to the HIV-1 long terminal repeat. FOXK2 may be involved in both, positive and negative regulation of important viral and cellular promoter elements. In addition, FOXK2 plays a critical role in suppressing tumorigenesis. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410800 [Multi-domain]  Cd Length: 78  Bit Score: 46.25  E-value: 1.26e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2416560123  18 QNSIRHNLSLHSRFMRVQ--NEGTGKSSWWIIN 48
Cdd:cd20026    46 QNSIRHNLSLNRYFIKVPrsQEEPGKGSFWRID 78
FH_FOXJ1 cd20023
Forkhead (FH) domain found in Forkhead box protein J1 (FOXJ1) and similar proteins; FOXJ1, ...
18-49 1.28e-06

Forkhead (FH) domain found in Forkhead box protein J1 (FOXJ1) and similar proteins; FOXJ1, also called Forkhead-related protein FKHL13 or hepatocyte nuclear factor 3 Forkhead homolog 4 (HFH-4), acts as a transcription factor specifically required for the formation of motile cilia. It acts by activating transcription of genes that mediate assembly of motile cilia, such as CFAP157. FOXJ1 binds the DNA consensus sequences 5'-HWDTGTTTGTTTA-3' or 5'-KTTTGTTGTTKTW-3' (where H is not G, W is A or T, D is not C, and K is G or T). It activates the transcription of a variety of ciliary proteins in the developing brain and lung. The FH domain is a winged helix DNA-binding domain.


Pssm-ID: 410797 [Multi-domain]  Cd Length: 79  Bit Score: 46.25  E-value: 1.28e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2416560123  18 QNSIRHNLSLHSRFMRV--QNEGTGKSSWWIINP 49
Cdd:cd20023    46 QNSIRHNLSLNKCFIKVprSKDEPGKGGFWRIDP 79
FH_FOXL2 cd20028
Forkhead (FH) domain found in Forkhead box protein L2 (FOXL2) and similar proteins; FOXL2 is a ...
18-50 3.74e-06

Forkhead (FH) domain found in Forkhead box protein L2 (FOXL2) and similar proteins; FOXL2 is a transcriptional regulator that is essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Mutations in the FOXL2 gene cause blepharophimosis-ptosis-epicanthus inversus syndrome (BPES) types I and II, a rare genetic disorder. In BPES type I, a complex eyelid malformation is associated with premature ovarian failure (POF), whereas in BPES type II, the eyelid defect occurs as an isolated entity. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410802 [Multi-domain]  Cd Length: 89  Bit Score: 45.13  E-value: 3.74e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2416560123  18 QNSIRHNLSLHSRFMRVQNEGTG--KSSWWIINPD 50
Cdd:cd20028    46 QNSIRHNLSLNECFVKVPREGGGerKGNYWTLDPA 80
FH_FOXJ2-like cd20024
Forkhead (FH) domain found in Forkhead box proteins, FOXJ2, FOXJ3 and similar proteins; The ...
18-47 4.19e-06

Forkhead (FH) domain found in Forkhead box proteins, FOXJ2, FOXJ3 and similar proteins; The FOXJ2-like subfamily includes two winged helix transcription factors, FOXJ2 and FOXJ3. FOXJ2, also called Forkhead homologous X (FHX), plays an important role in tumorigenesis, progression, and metastasis of certain cancers. It acts as a transcriptional activator that can bind to two different type of DNA binding sites. FOXJ3 is a transcription factor which regulates sperm function. It transcriptionally activates Mef2c and regulates adult skeletal muscle fiber type identity. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410798 [Multi-domain]  Cd Length: 77  Bit Score: 44.65  E-value: 4.19e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2416560123  18 QNSIRHNLSLHSRFMRV--QNEGTGKSSWWII 47
Cdd:cd20024    46 KNSIRHNLSLNKCFKKVprSKDDPGKGSYWTL 77
FH_FOXL1 cd20027
Forkhead (FH) domain found in Forkhead box protein L1 (FOXL1) and similar proteins; FOXL1, ...
18-50 9.24e-06

Forkhead (FH) domain found in Forkhead box protein L1 (FOXL1) and similar proteins; FOXL1, also called Forkhead-related protein FKHL11 or Forkhead-related transcription factor 7 (FREAC-7), acts as a transcription factor required for proper proliferation and differentiation in the gastrointestinal epithelium. It may play a critical role in suppressing tumorigenesis. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410801  Cd Length: 98  Bit Score: 44.42  E-value: 9.24e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2416560123  18 QNSIRHNLSLHSRFMRVQNEGT--GKSSWWIINPD 50
Cdd:cd20027    48 QNSIRHNLSLNDCFVKVPREKGrpGKGNYWTLDPD 82
FH_FOXM cd20029
Forkhead (FH) domain found in the Forkhead box protein M (FOXM) subfamily; The FOXM subfamily ...
18-49 1.14e-05

Forkhead (FH) domain found in the Forkhead box protein M (FOXM) subfamily; The FOXM subfamily includes a winged helix transcription factor, FOXM1, which is also called Forkhead-related protein FKHL16, Hepatocyte nuclear factor 3 Forkhead homolog 11 (HFH-11), HNF-3/fork-head homolog 11, M-phase phosphoprotein 2, MPM-2 reactive phosphoprotein 2, transcription factor Trident, or Winged-helix factor from INS-1 cells. FOXM1 acts as a transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. It plays a role in the control of cell proliferation. It is also involved in DNA break repair, participating in the DNA damage checkpoint response. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410803 [Multi-domain]  Cd Length: 77  Bit Score: 43.18  E-value: 1.14e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2416560123  18 QNSIRHNLSLHSRFMRvQNEGTGKSSWWIINP 49
Cdd:cd20029    47 KNSIRHNLSLHDIFVR-ETSANGKGSFWTLRP 77
FH_FOXE cd20019
Forkhead (FH) domain found in the Forkhead box protein E (FOXE) subfamily; The FOXE subfamily ...
18-61 3.49e-05

Forkhead (FH) domain found in the Forkhead box protein E (FOXE) subfamily; The FOXE subfamily includes two winged helix transcription factors, FOXE1 (also known as FOXE2) and FOXE3. FOXE1, also called Forkhead-related protein FKHL15, HFKH4, HNF-3/fork head-like protein 5 (HFKL5), or thyroid transcription factor 2 (TTF-2), is a transcription factor that binds consensus sites on a variety of gene promoters and activate their transcription. FOXE3, also called Forkhead-related protein FKHL12 or Forkhead-related transcription factor 8 (FREAC-8), is a transcription factor that controls lens epithelial cell growth through regulation of proliferation, apoptosis, and the cell cycle. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410793  Cd Length: 94  Bit Score: 42.48  E-value: 3.49e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2416560123  18 QNSIRHNLSLHSRFMRVQNE--GTGKSSWWIINP---DGGKSGKAPRRR 61
Cdd:cd20019    46 QNSIRHNLTLNDCFVKIPREpgRPGKGNYWTLDPaaeDMFDNGSFLRRR 94
FH_FOXD4-like cd20048
Forkhead (FH) domain found in Forkhead box protein D4 (FOXD4) and similar proteins; FOXD4, ...
18-61 4.66e-05

Forkhead (FH) domain found in Forkhead box protein D4 (FOXD4) and similar proteins; FOXD4, also called Forkhead-related protein FKHL9, Forkhead-related transcription factor 5 (FREAC-5), or myeloid factor-alpha, is essential for establishing neural cell fate and for neuronal differentiation. The family also includes Forkhead box protein D4-like proteins, FOXD4L1-6. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410822  Cd Length: 96  Bit Score: 42.18  E-value: 4.66e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2416560123  18 QNSIRHNLSLHSRFMRVQNE--GTGKSSWWIINP---DGGKSGKAPRRR 61
Cdd:cd20048    46 QNSIRHNLSLNDCFVKIPREpgHPGKGNYWSLDPasqDMFDNGSFLRRR 94
FH_FOXS1 cd20037
Forkhead (FH) domain found in Forkhead box protein S1 (FOXS1); FOXS1, also called ...
18-50 9.70e-05

Forkhead (FH) domain found in Forkhead box protein S1 (FOXS1); FOXS1, also called Forkhead-like 18 protein or Forkhead-related transcription factor 10 (FREAC-10), is a transcriptional repressor that suppresses transcription from the FASLG, FOXO3, and FOXO4 promoters. It may have a role in the organization of the testicular vasculature. It has also been implicated in energy turnover, motor function, and body weight. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410811  Cd Length: 100  Bit Score: 41.54  E-value: 9.70e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2416560123  18 QNSIRHNLSLHSRFMRV--QNEGTGKSSWWIINPD 50
Cdd:cd20037    47 QNSIRHNLSLNECFVKVprDDRKPGKGSYWTLDPD 81
FH_FOXC2 cd20045
Forkhead (FH) domain found in Forkhead box protein C2 (FOXC2) and similar proteins; FOXC2, ...
18-50 1.43e-04

Forkhead (FH) domain found in Forkhead box protein C2 (FOXC2) and similar proteins; FOXC2, also called Forkhead-related protein FKHL14, Mesenchyme fork head protein 1 (MFH-1 protein), or transcription factor FKH-14, acts as a transcriptional activator that might be involved in the formation of special mesenchymal tissues. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410819  Cd Length: 90  Bit Score: 40.84  E-value: 1.43e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2416560123  18 QNSIRHNLSLHSRFMRV--QNEGTGKSSWWIINPD 50
Cdd:cd20045    48 QNSIRHNLSLNECFVKVprDDKKPGKGSYWTLDPD 82
FH_FOXN3 cd20059
Forkhead (FH) domain found in Forkhead box protein N3 (FOXN3); FOXN3, also called checkpoint ...
18-50 1.60e-04

Forkhead (FH) domain found in Forkhead box protein N3 (FOXN3); FOXN3, also called checkpoint suppressor 1 (CHES1), acts as a transcriptional repressor that may be involved in DNA damage-inducible cell cycle arrests (checkpoints). It displays transcriptional inhibitory activity, and is involved in cell cycle regulation and tumorigenesis. Alterations in FOXN3 are found in of a variety of cancers including melanoma, osteosarcoma, and hepatocellular carcinoma. FOXN3 also regulates hepatic glucose utilization/metabolism by regulating gluconeogenic substrate selection. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410833 [Multi-domain]  Cd Length: 90  Bit Score: 40.61  E-value: 1.60e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2416560123  18 QNSIRHNLSLHSRFMRVQNE---GTGKSSWWIINPD 50
Cdd:cd20059    46 KNSVRHNLSLNKCFKKVDKEkgqSIGKGSLWCIDPE 81
FH_FOXC1 cd20044
Forkhead (FH) domain found in Forkhead box protein C1 (FOXC1) and similar proteins; FOXC1, ...
18-50 2.13e-04

Forkhead (FH) domain found in Forkhead box protein C1 (FOXC1) and similar proteins; FOXC1, also called Forkhead-related protein FKHL7, or Forkhead-related transcription factor 3 (FREAC-3), is a DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as the development of the eyes, bones, cardiovascular system, kidneys, and skin. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410818  Cd Length: 93  Bit Score: 40.46  E-value: 2.13e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2416560123  18 QNSIRHNLSLHSRFMRV--QNEGTGKSSWWIINPD 50
Cdd:cd20044    51 QNSIRHNLSLNECFVKVprDDKKPGKGSYWTLDPD 85
FH_FOXG cd20021
Forkhead (FH) domain found in the Forkhead box protein G (FOXG) subfamily; The FOXG subfamily ...
18-49 2.52e-04

Forkhead (FH) domain found in the Forkhead box protein G (FOXG) subfamily; The FOXG subfamily includes a winged helix transcription factor FOXG1, which is also called brain factor 1 (BF-1), brain factor 2 (BF-2), Forkhead box protein G1A, Forkhead box protein G1B, Forkhead box protein G1C, Forkhead-related protein FKHL1, Forkhead-related protein FKHL2, or Forkhead-related protein FKHL3. FOXG1 acts as a transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon. It is repetitively used in the sequential events of telencephalic development to control multi-steps of brain circuit formation ranging from cell cycle control to neuronal differentiation in a clade- and species-specific manner. Individuals with mutations in FOXG1 harbor "FOXG1-related encephalopathy", characterized by two clinical phenotypes/syndromes including microcephaly, developmental delay, severe cognitive disabilities, early-onset dyskinesia and hyperkinetic movements, stereotypies, epilepsy, and cerebral malformation for those with deletions or intragenic mutations of FOXG1. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410795 [Multi-domain]  Cd Length: 79  Bit Score: 39.47  E-value: 2.52e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2416560123  18 QNSIRHNLSLHSRFMRVQN--EGTGKSSWWIINP 49
Cdd:cd20021    46 QNSIRHNLSLNKCFVKVPRhyDDPGKGNYWMLDP 79
FH_FOXD1_D2-like cd20046
Forkhead (FH) domain found in Forkhead box proteins FOXD1, FOXD2 and similar proteins; FOXD1, ...
18-61 3.44e-04

Forkhead (FH) domain found in Forkhead box proteins FOXD1, FOXD2 and similar proteins; FOXD1, also called Forkhead-related protein FKHL8, or Forkhead-related transcription factor 4 (FREAC-4), is involved in transcriptional activation of Placental Growth Factor (PGF) and the complement component (C3) genes. It plays an important role in early embryonic development and organogenesis, and functions as an oncogene in several cancers. FOXD2, also called Forkhead-related protein FKHL17, or Forkhead-related transcription factor 9 (FREAC-9), is a probable transcription factor involved in embryogenesis and somatogenesis. It has been found that long noncoding RNA FOXD2 adjacent opposite strand RNA1 (lncRNA FOXD2-AS1) expression is upregulated in various human malignancies, including gastric, lung, bladder, colorectal, nasopharyngeal, esophageal, hepatocellular, thyroid and skin cancer. It is a promising candidate as a new biomarker and therapeutic target for cancer diagnosis/prognostication due to high tissue specificity and elevated efficiency. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410820  Cd Length: 99  Bit Score: 39.68  E-value: 3.44e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2416560123  18 QNSIRHNLSLHSRFMRVQNE--GTGKSSWWIINPDGG---KSGKAPRRR 61
Cdd:cd20046    46 QNSIRHNLSLNDCFVKIPREpgNPGKGNYWTLDPESAdmfDNGSFLRRR 94
FH_FOXK2 cd20055
Forkhead (FH) domain found in Forkhead box protein K2 (FOXK2) and similar proteins; FOXK2, ...
18-49 3.69e-04

Forkhead (FH) domain found in Forkhead box protein K2 (FOXK2) and similar proteins; FOXK2, also called cellular transcription factor ILF-1 or interleukin enhancer-binding factor 1, is a transcriptional regulator that recognizes the core sequence 5'-TAAACA-3'. It binds to NFAT-like motifs (purine-rich) in the IL2 promoter. It also binds to the HIV-1 long terminal repeat. FOXK2 may be involved in both, positive and negative regulation of important viral and cellular promoter elements. In addition, FOXK2 plays a critical role in suppressing tumorigenesis. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410829 [Multi-domain]  Cd Length: 98  Bit Score: 39.80  E-value: 3.69e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2416560123  18 QNSIRHNLSLHSRFMRV--QNEGTGKSSWWIINP 49
Cdd:cd20055    48 QNSIRHNLSLNRYFIKVprSQEEPGKGSFWRIDP 81
FH_FOXQ1-like cd20034
Forkhead (FH) domain found in Forkhead box protein Q1 (FOXQ1) and similar proteins; FOXQ1, ...
18-48 3.72e-04

Forkhead (FH) domain found in Forkhead box protein Q1 (FOXQ1) and similar proteins; FOXQ1, also called HNF-3/Forkhead-like protein 1 (HFH-1), or hepatocyte nuclear factor 3 Forkhead homolog 1, plays a role in hair follicle differentiation. It has also been reported to promote epithelial differentiation, inhibit smooth muscle differentiation, activate T cells and autoimmunity, and control mucin gene expression and granule content in stomach surface mucous cells. FOXQ1 is significantly associated with the pathogenesis of various tumor types including gastric, breast, colorectal, pancreatic, bladder and ovarian cancer, and glioma. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410808 [Multi-domain]  Cd Length: 79  Bit Score: 39.33  E-value: 3.72e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2416560123  18 QNSIRHNLSLHSRFMRVQNEGT---GKSSWWIIN 48
Cdd:cd20034    46 RNSVRHNLSLNDCFVKVLRDPSrpwGKDNYWTIN 79
FH_FOXK1 cd20054
Forkhead (FH) domain found in Forkhead box protein K1 (FOXK1) and similar proteins; FOXK1, ...
18-49 4.26e-04

Forkhead (FH) domain found in Forkhead box protein K1 (FOXK1) and similar proteins; FOXK1, also called myocyte nuclear factor (MNF), acts as a transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin genes. It positively regulates Wnt/beta-catenin signaling by translocating dishevelled (DVL) proteins into the nucleus. It also reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression. In addition, FOXK1 plays important roles in multiple human cancers. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410828 [Multi-domain]  Cd Length: 101  Bit Score: 39.81  E-value: 4.26e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2416560123  18 QNSIRHNLSLHSRFMRV--QNEGTGKSSWWIINP 49
Cdd:cd20054    48 QNSIRHNLSLNRYFIKVprSQEEPGKGSFWRIDP 81
FH_FOXP cd20033
Forkhead (FH) domain found in the Forkhead box protein P (FOXP) subfamily; The FOXP subfamily ...
18-48 5.33e-04

Forkhead (FH) domain found in the Forkhead box protein P (FOXP) subfamily; The FOXP subfamily includes four winged helix transcription factors, FOXP1-4. They are involved in the development of the central nervous system. Mutations in FOXP1, also called Mac-1-regulated Forkhead (MFH), leads to developmental delay, intellectual disability, autism spectrum disorder, speech delay, and dysmorphic features. FOXP2, also called CAG repeat protein 44 or Trinucleotide repeat-containing gene 10 protein, is a transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. It may also play a role in developing neural, gastrointestinal and cardiovascular tissues. FOXP3, also called Scurfin, is a transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). FOXP4, also called Forkhead-related protein-like A, is a transcriptional repressor that represses lung-specific expression. It is necessary for normal T cell cytokine recall responses to antigen following pathogenic infection. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410807 [Multi-domain]  Cd Length: 73  Bit Score: 38.57  E-value: 5.33e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 2416560123  18 QNSIRHNLSLHSRFMRVQNegtGKSSWWIIN 48
Cdd:cd20033    46 KNAVRHNLSLHKCFVRVEN---VKGAVWTVD 73
FH_FOXJ3 cd20052
Forkhead (FH) domain found in Forkhead box protein J3 (FOXJ3) and similar proteins; FOXJ3 is a ...
18-48 7.78e-04

Forkhead (FH) domain found in Forkhead box protein J3 (FOXJ3) and similar proteins; FOXJ3 is a transcription factor which regulates sperm function. It transcriptionally activates Mef2c and regulates adult skeletal muscle fiber type identity. Polymorphisms in the FOXJ3 gene may be associated with the development of rheumatoid arthritis. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410826 [Multi-domain]  Cd Length: 79  Bit Score: 38.47  E-value: 7.78e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2416560123  18 QNSIRHNLSLHSRFMRV--QNEGTGKSSWWIIN 48
Cdd:cd20052    47 KNSIRHNLSLNKCFLKVprSKDDPGKGSYWAID 79
FH_FOXD3 cd20047
Forkhead (FH) domain found in Forkhead box protein D3 (FOXD3) and similar proteins; FOXD3, ...
18-61 7.89e-04

Forkhead (FH) domain found in Forkhead box protein D3 (FOXD3) and similar proteins; FOXD3, also called HNF3/FH transcription factor genesis, acts as a transcriptional repressor that binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3'. It also acts as a transcriptional activator. It promotes development of neural crest cells from neural tube progenitors and restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. FOXD3 is required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis. The FH domain is a winged helix DNA-binding domain.


Pssm-ID: 410821  Cd Length: 97  Bit Score: 38.93  E-value: 7.89e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2416560123  18 QNSIRHNLSLHSRFMRVQNE--GTGKSSWWIINP---DGGKSGKAPRRR 61
Cdd:cd20047    47 QNSIRHNLSLNDCFVKIPREpgNPGKGNYWTLDPqseDMFDNGSFLRRR 95
FH_FOXN1-like cd20030
Forkhead (FH) domain found in Forkhead box protein N1 (FOXN1) and similar proteins; The ...
18-49 9.55e-04

Forkhead (FH) domain found in Forkhead box protein N1 (FOXN1) and similar proteins; The FOXN1-like group includes two FOXN subfamily winged helix transcription factors, FOXN1 and FOXN4. FOXN1, also called winged helix transcription factor nude, acts as a transcriptional regulator which regulates the development, differentiation, and function of thymic epithelial cells (TECs), both in the prenatal and postnatal thymus. FOXN4 acts as a transcription factor essential for neural and some non-neural tissue development, such as retina and lung, respectively. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410804 [Multi-domain]  Cd Length: 81  Bit Score: 38.19  E-value: 9.55e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2416560123  18 QNSIRHNLSLHSRFMRVQNEGTG----KSSWWIINP 49
Cdd:cd20030    46 KNSVRHNLSLNKCFEKIERPDGNgssrKGCLWALNP 81
FH_dFKH cd20041
Forkhead (FH) domain found in Drosophila melanogaster protein fork head (dFKH) and similar ...
18-52 1.06e-03

Forkhead (FH) domain found in Drosophila melanogaster protein fork head (dFKH) and similar proteins; dFKH promotes terminal as opposed to segmental development. In the absence of dFKH, this developmental switch does not occur. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410815 [Multi-domain]  Cd Length: 98  Bit Score: 38.41  E-value: 1.06e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2416560123  18 QNSIRHNLSLHSRFMRVQN--EGTGKSSWWIINPDGG 52
Cdd:cd20041    46 QNSIRHSLSFNDCFVKVPRtpDKPGKGSFWTLHPDSG 82
FH_FOXC cd20017
Forkhead (FH) domain found in the Forkhead box protein C (FOXC) subfamily; The FOXC subfamily ...
18-45 1.31e-03

Forkhead (FH) domain found in the Forkhead box protein C (FOXC) subfamily; The FOXC subfamily includes two winged helix transcription factors, FOXC1 (also called Forkhead-related protein FKHL7, or Forkhead-related transcription factor 3) and FOXC2 (also called Forkhead-related protein FKHL14, or Mesenchyme fork head protein 1). FOXC1 is a DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as the development of the eyes, bones, cardiovascular system, kidneys, and skin. FOXC2 acts as a transcriptional activator that might be involved in the formation of special mesenchymal tissues. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410791 [Multi-domain]  Cd Length: 77  Bit Score: 37.62  E-value: 1.31e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 2416560123  18 QNSIRHNLSLHSRFMRV--QNEGTGKSSWW 45
Cdd:cd20017    46 QNSIRHNLSLNECFVKVprDDKKPGKGSYW 75
FH_FOXP3 cd20066
Forkhead (FH) domain found in Forkhead box protein P3 (FOXP3) and similar proteins; FOXP3, ...
18-48 1.70e-03

Forkhead (FH) domain found in Forkhead box protein P3 (FOXP3) and similar proteins; FOXP3, also called Scurfin, is a transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg), which are required for maintaining self-tolerance. It may also have intrinsic regulatory function in conventional T (Tconv) cells. A deletion of the Forkhead domain arising from a frame-shift mutation in mouse FOXP3 is linked to the autoimmune disorder scurfy, and a similar congenital disease in humans is known as IPEX (immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome). The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410840 [Multi-domain]  Cd Length: 81  Bit Score: 37.25  E-value: 1.70e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 2416560123  18 QNSIRHNLSLHSRFMRVQNEgtgKSSWWIIN 48
Cdd:cd20066    46 KNAVRHNLSLHKCFVRVENE---KGAVWTVD 73
FH_FOXA cd20015
Forkhead (FH) domain found in the Forkhead box protein A (FOXA) subfamily; The FOXA subfamily ...
18-52 2.11e-03

Forkhead (FH) domain found in the Forkhead box protein A (FOXA) subfamily; The FOXA subfamily includes three winged helix transcription factors, FOXA1 (also called hepatocyte nuclear factor 3-alpha or transcription factor 3A), FOXA2 (also called hepatocyte nuclear factor 3-beta or transcription factor 3B), and FOXA3 (also called hepatocyte nuclear factor 3-gamma or transcription factor 3G). FOXA1 is essential for epithelial lineage differentiation and has been found to be upregulated in numerous cancers. FOXA2 controls cell differentiation. It is a key transcriptional regulator that maintains airway mucus homeostasis and may also have an important role in bone metabolism. FOXA3 acts as an essential transcriptional regulator engaged in adipogenesis and energy metabolism. This subfamily also includes Xenopus tropicalis FOXA4, Drosophila melanogaster protein fork head (dFKH), and similar proteins. FOXA4 is only present in amphibians, where it is required for the correct regionalization and maintenance of the central nervous system. dFKH promotes terminal as opposed to segmental development. In the absence of dFKH, this developmental switch does not occur. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410789 [Multi-domain]  Cd Length: 97  Bit Score: 37.61  E-value: 2.11e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2416560123  18 QNSIRHNLSLHSRFMRVQN--EGTGKSSWWIINPDGG 52
Cdd:cd20015    46 QNSIRHSLSFNDCFVKVPRspDKPGKGSYWTLHPDSG 82
FH_FOXA1 cd20038
Forkhead (FH) domain found in Forkhead box protein A1 (FOXA1) and similar proteins; FOXA1, ...
18-52 2.22e-03

Forkhead (FH) domain found in Forkhead box protein A1 (FOXA1) and similar proteins; FOXA1, also called hepatocyte nuclear factor 3-alpha (HNF-3-alpha or HNF-3A) or transcription factor 3A (TCF-3A), acts as a transcription factor that is essential for epithelial lineage differentiation. It has been found to be upregulated in numerous cancers. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410812 [Multi-domain]  Cd Length: 112  Bit Score: 37.80  E-value: 2.22e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2416560123  18 QNSIRHNLSLHSRFMRVQN--EGTGKSSWWIINPDGG 52
Cdd:cd20038    59 QNSIRHSLSFNDCFVKVARspDKPGKGSYWTLHPDSG 95
FH_FOXA2 cd20039
Forkhead (FH) domain found in Forkhead box protein A2 (FOXA2) and similar proteins; FOXA2, ...
18-52 2.47e-03

Forkhead (FH) domain found in Forkhead box protein A2 (FOXA2) and similar proteins; FOXA2, also called hepatocyte nuclear factor 3-beta (HNF-3-beta or HNF-3B) or transcription factor 3B (TCF-3B), acts as a core transcription factor that controls cell differentiation. It is a key transcriptional regulator that maintains airway mucus homeostasis. It may also have an important role in bone metabolism. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410813 [Multi-domain]  Cd Length: 104  Bit Score: 37.40  E-value: 2.47e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2416560123  18 QNSIRHNLSLHSRFMRVQN--EGTGKSSWWIINPDGG 52
Cdd:cd20039    50 QNSIRHSLSFNDCFLKVPRspDKPGKGSFWTLHPDSG 86
FH_FOXB cd20016
Forkhead (FH) domain found in the Forkhead box protein B (FOXB) subfamily; The FOXB subfamily ...
18-49 2.87e-03

Forkhead (FH) domain found in the Forkhead box protein B (FOXB) subfamily; The FOXB subfamily includes two winged helix transcription factors, FOXB1 (also called transcription factor FKH-5) and FOXB2 (also called transcription factor FKH-4). FOXB1 controls development of mammary glands and regions of the central nervous system (CNS) that regulate the milk-ejection reflex. It is essential for access of mammillothalamic axons to the thalamus. FOXB2 may act as a tumor suppressor; it has been found to inhibit the malignant characteristics of the pancreatic cancer cell line Panc-1 in vitro. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410790 [Multi-domain]  Cd Length: 79  Bit Score: 36.72  E-value: 2.87e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2416560123  18 QNSIRHNLSLHSRFMRVQNEGT--GKSSWWIINP 49
Cdd:cd20016    46 QNSLRHNLSFNDCFIKIPRRPDrpGKGSYWALHP 79
FH_FOXN2 cd20058
Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2); FOXN2, also called human T-cell ...
18-50 3.16e-03

Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2); FOXN2, also called human T-cell leukemia virus enhancer factor (HTLF), is a potential tumor suppressor that can facilitate replication fork reversal. It acts as a transcription factor that binds to the purine-rich region in human T-cell leukemia virus long terminal repeat (HTLV-I LTR). It may be a potential therapeutic and radiosensitization target for lung cancer. FOXN2 has also been found to be down-regulated in breast cancer, where it regulates migration, invasion, and epithelial-mesenchymal transition. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410832 [Multi-domain]  Cd Length: 82  Bit Score: 36.55  E-value: 3.16e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2416560123  18 QNSIRHNLSLHSRFMRVQ---NEGTGKSSWWIINPD 50
Cdd:cd20058    47 KNSVRHNLSLNKCFRKVErshGKVNGKGSLWCVDPE 82
FH_FOXB2 cd20043
Forkhead (FH) domain found in Forkhead box protein B2 (FOXB2) and similar proteins; FOXB2, ...
18-61 3.96e-03

Forkhead (FH) domain found in Forkhead box protein B2 (FOXB2) and similar proteins; FOXB2, also called transcription factor FKH-4, may act as a transcription factor. It may also act as a tumor suppressor; it has been found to inhibit the malignant characteristics of the pancreatic cancer cell line Panc-1 in vitro. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410817 [Multi-domain]  Cd Length: 110  Bit Score: 36.96  E-value: 3.96e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2416560123  18 QNSIRHNLSLHSRFMRV--QNEGTGKSSWWIINPDGG---KSGKAPRRR 61
Cdd:cd20043    58 QNSLRHNLSFNDCFIKIprRPDQPGKGSFWALHPDCGdmfENGSFLRRR 106
FH_FOXN2-like cd20031
Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2) and similar proteins; The ...
19-47 4.96e-03

Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2) and similar proteins; The FOXN2-like group includes two FOXN subfamily winged helix transcription factors, FOXN2 and FOXN3. FOXN2, also called human T-cell leukemia virus enhancer factor (HTLF), is a potential tumor suppressor that can facilitate replication fork reversal. It acts as a transcription factor that binds to the purine-rich region in human T-cell leukemia virus long terminal repeat (HTLV-I LTR). It may be a potential therapeutic and radiosensitization target for lung cancer. FOXN3, also called checkpoint suppressor 1, acts as a transcriptional repressor that may be involved in DNA damage-inducible cell cycle arrests (checkpoints). The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410805 [Multi-domain]  Cd Length: 76  Bit Score: 35.79  E-value: 4.96e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 2416560123  19 NSIRHNLSLHSRFMRVQNEGT-GKSSWWII 47
Cdd:cd20031    47 NSIRHNLSLNKCFKKVEKEKNkGKGSLWCV 76
FH_FOXI1 cd20053
Forkhead (FH) domain found in Forkhead box protein I1 (FOXI1) and similar proteins; FOXI1 is ...
18-61 5.55e-03

Forkhead (FH) domain found in Forkhead box protein I1 (FOXI1) and similar proteins; FOXI1 is also called Forkhead-related protein FKHL10, Forkhead-related transcription factor 6 (FREAC-6), Hepatocyte nuclear factor 3 Forkhead homolog 3 (HFH-3), or HNF-3/fork-head homolog 3. It is a master regulator of vacuolar H-ATPase proton pump subunits in the inner ear, kidney, and epididymis, and is required for the development of normal hearing, sense of balance, and kidney function. Its epididymal expression is required for male fertility. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410827  Cd Length: 100  Bit Score: 36.62  E-value: 5.55e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2416560123  18 QNSIRHNLSLHSRFMRV--QNEGTGKSSWWIINPDGGK---SGKAPRRR 61
Cdd:cd20053    49 QNSIRHNLSLNDCFKKVprDEDDPGKGNYWTLDPNCEKmfdNGNFRRKR 97
FH_FOXI cd20025
Forkhead (FH) domain found in the Forkhead box protein I (FOXI) subfamily; The FOXI subfamily ...
18-48 8.02e-03

Forkhead (FH) domain found in the Forkhead box protein I (FOXI) subfamily; The FOXI subfamily includes three human winged helix transcription factors, FOXI1-3, Xenopus laevis FoxI1c, and similar proteins. FOXI1 acts as a transcriptional activator required for the development of normal hearing, sense of balance, and kidney function. FOXI2 may act as a transcriptional activator that plays a possible role in controlling cellular identity. Loss of function mutations in the FOXI2 gene may contribute to ectodermal dysplasia. FOXI3 plays a critical role in the development of the inner ear and jaw. It is a regulator of ectodermal development. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410799 [Multi-domain]  Cd Length: 77  Bit Score: 35.20  E-value: 8.02e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2416560123  18 QNSIRHNLSLHSRFMRV--QNEGTGKSSWWIIN 48
Cdd:cd20025    45 QNSIRHNLSLNDCFKKVprDEDDPGKGNYWTLD 77
FH_FOXD cd20018
Forkhead (FH) domain found in the Forkhead box protein D (FOXD) subfamily; The FOXD subfamily ...
18-48 9.86e-03

Forkhead (FH) domain found in the Forkhead box protein D (FOXD) subfamily; The FOXD subfamily includes four winged helix transcription factors, FOXD1-4. FOXD1, also called Forkhead-related protein FKHL8 or Forkhead-related transcription factor 4 (FREAC-4), is involved in transcriptional activation of Placental Growth Factor (PGF) and the complement component (C3) genes. It plays an important role in early embryonic development and organogenesis, and functions as an oncogene in several cancers. FOXD2, also called Forkhead-related protein FKHL17 or Forkhead-related transcription factor 9 (FREAC-9), is a probable transcription factor involved in embryogenesis and somatogenesis. FOXD3, also called HNF3/FH transcription factor genesis, acts as a transcriptional repressor that binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3'. It also acts as a transcriptional activator. It promotes development of neural crest cells from neural tube progenitors and restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. FOXD3 is required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis. FOXD4, also called Forkhead-related protein FKHL9 or Forkhead-related transcription factor 5 (FREAC-5), is essential for establishing neural cell fate and for neuronal differentiation. The family also includes Forkhead box protein D4-like proteins, FOXD4L1-6. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410792 [Multi-domain]  Cd Length: 78  Bit Score: 35.23  E-value: 9.86e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2416560123  18 QNSIRHNLSLHSRFMRVQNE--GTGKSSWWIIN 48
Cdd:cd20018    46 QNSIRHNLSLNDCFVKIPREpgNPGKGNYWTLD 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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