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Conserved domains on  [gi|2464172608|ref|NP_001405663|]
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WAP four-disulfide core domain protein 3 precursor [Mus musculus]

Protein Classification

WAP domain-containing protein( domain architecture ID 10442762)

WAP domain-containing protein similar to whey acidic protein (WAP) that could be a protease inhibitor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WAP pfam00095
WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or ...
 23-57 5.86e-05

WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or elastase-specific inhibitors.


:

Pssm-ID: 459672 [Multi-domain]  Cd Length: 42  Bit Score: 38.17  E-value: 5.86e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2464172608  23 GECPA--DPLPCQELCTGDESCPQGHKCCSTGCGHAC 57
Cdd:pfam00095   3 GCCPRlgARGCCRSCCSSDDDCPGRQKCCSNGCGSVC 39
WAP pfam00095
WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or ...
 65-105 6.05e-04

WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or elastase-specific inhibitors.


:

Pssm-ID: 459672 [Multi-domain]  Cd Length: 42  Bit Score: 35.48  E-value: 6.05e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2464172608  65 RDGQCPRILV-GLCIVQCMMDENCQSGERCCKSGCGRFCIPG 105
Cdd:pfam00095   1 KPGCCPRLGArGCCRSCCSSDDDCPGRQKCCSNGCGSVCVPP 42
 
Name Accession Description Interval E-value
WAP pfam00095
WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or ...
 23-57 5.86e-05

WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or elastase-specific inhibitors.


Pssm-ID: 459672 [Multi-domain]  Cd Length: 42  Bit Score: 38.17  E-value: 5.86e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2464172608  23 GECPA--DPLPCQELCTGDESCPQGHKCCSTGCGHAC 57
Cdd:pfam00095   3 GCCPRlgARGCCRSCCSSDDDCPGRQKCCSNGCGSVC 39
WAP pfam00095
WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or ...
 65-105 6.05e-04

WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or elastase-specific inhibitors.


Pssm-ID: 459672 [Multi-domain]  Cd Length: 42  Bit Score: 35.48  E-value: 6.05e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2464172608  65 RDGQCPRILV-GLCIVQCMMDENCQSGERCCKSGCGRFCIPG 105
Cdd:pfam00095   1 KPGCCPRLGArGCCRSCCSSDDDCPGRQKCCSNGCGSVCVPP 42
WAP cd00199
whey acidic protein-type four-disulfide core domains. Members of the family include whey ...
 23-57 1.48e-03

whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of proteins containing 8 characteristically-spaced cysteine residuesforming disulphide bonds, have been termed '4-disulphide core' proteins. Protease inhibition occurs by insertion of the inhibitory loop into the active site pocket and interference with the catalytic residues of the protease.


Pssm-ID: 238120 [Multi-domain]  Cd Length: 60  Bit Score: 34.73  E-value: 1.48e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2464172608  23 GECPADPLP----CQELCTGDESCPQGHKCCSTGCGHAC 57
Cdd:cd00199    18 GRCPMVNPPslgiPPNRCSSDSDCPGDKKCCENGCGKSC 56
WAP smart00217
Four-disulfide core domains;
29-57 3.33e-03

Four-disulfide core domains;


Pssm-ID: 197580 [Multi-domain]  Cd Length: 47  Bit Score: 33.50  E-value: 3.33e-03
                           10        20
                   ....*....|....*....|....*....
gi 2464172608   29 PLPCQELCTGDESCPQGHKCCSTGCGHAC 57
Cdd:smart00217  15 LGNPPNKCSSDSQCPGVKKCCFNGCGKSC 43
 
Name Accession Description Interval E-value
WAP pfam00095
WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or ...
 23-57 5.86e-05

WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or elastase-specific inhibitors.


Pssm-ID: 459672 [Multi-domain]  Cd Length: 42  Bit Score: 38.17  E-value: 5.86e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2464172608  23 GECPA--DPLPCQELCTGDESCPQGHKCCSTGCGHAC 57
Cdd:pfam00095   3 GCCPRlgARGCCRSCCSSDDDCPGRQKCCSNGCGSVC 39
WAP pfam00095
WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or ...
 65-105 6.05e-04

WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or elastase-specific inhibitors.


Pssm-ID: 459672 [Multi-domain]  Cd Length: 42  Bit Score: 35.48  E-value: 6.05e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2464172608  65 RDGQCPRILV-GLCIVQCMMDENCQSGERCCKSGCGRFCIPG 105
Cdd:pfam00095   1 KPGCCPRLGArGCCRSCCSSDDDCPGRQKCCSNGCGSVCVPP 42
WAP cd00199
whey acidic protein-type four-disulfide core domains. Members of the family include whey ...
 23-57 1.48e-03

whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of proteins containing 8 characteristically-spaced cysteine residuesforming disulphide bonds, have been termed '4-disulphide core' proteins. Protease inhibition occurs by insertion of the inhibitory loop into the active site pocket and interference with the catalytic residues of the protease.


Pssm-ID: 238120 [Multi-domain]  Cd Length: 60  Bit Score: 34.73  E-value: 1.48e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2464172608  23 GECPADPLP----CQELCTGDESCPQGHKCCSTGCGHAC 57
Cdd:cd00199    18 GRCPMVNPPslgiPPNRCSSDSDCPGDKKCCENGCGKSC 56
WAP smart00217
Four-disulfide core domains;
29-57 3.33e-03

Four-disulfide core domains;


Pssm-ID: 197580 [Multi-domain]  Cd Length: 47  Bit Score: 33.50  E-value: 3.33e-03
                           10        20
                   ....*....|....*....|....*....
gi 2464172608   29 PLPCQELCTGDESCPQGHKCCSTGCGHAC 57
Cdd:smart00217  15 LGNPPNKCSSDSQCPGVKKCCFNGCGKSC 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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