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Conserved domains on  [gi|2468055602|ref|NP_001405956|]
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clusterin-associated protein 1 isoform 9 [Mus musculus]

Protein Classification

Cluap1 superfamily-containing protein( domain architecture ID 709433)

Cluap1 superfamily-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Cluap1 super family cl25650
Clusterin-associated protein-1; This protein is conserved from worms to humans. The protein of ...
1-99 1.18e-48

Clusterin-associated protein-1; This protein is conserved from worms to humans. The protein of 413 amino acids contains a central coiled-coil domain, possibly the region that binds to clusterin. Cluap1 expression is highest in the nucleus and gradually increases during late S to G2/M phases of the cell cycle and returns to the basal level in the G0/G1 phases. In addition, it is upregulated in colon cancer tissues compared to corresponding non-cancerous mucosa. It thus plays a crucial role in the life of the cell.


The actual alignment was detected with superfamily member pfam10234:

Pssm-ID: 463013 [Multi-domain]  Cd Length: 268  Bit Score: 161.21  E-value: 1.18e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468055602   1 MRIAIKDLLAQVQKTKDLLNNVASDEANLEAKIEKRKLELERNRKRLQTLQSVRPAFMDEYEKVEEDLQKQYDVYLEKFR 80
Cdd:pfam10234 170 LKEAIKNVAAEIEQTQKQLENLASDEANLEAKIEKKKQELERNQKRLQTLQSVRPAFMDEYEKLEEELQKLYEEYVEKFR 249
                          90
                  ....*....|....*....
gi 2468055602  81 NLAYLEQQLEDHHRMEQER 99
Cdd:pfam10234 250 NLSYLEHQLEKYNKAEQER 268
 
Name Accession Description Interval E-value
Cluap1 pfam10234
Clusterin-associated protein-1; This protein is conserved from worms to humans. The protein of ...
1-99 1.18e-48

Clusterin-associated protein-1; This protein is conserved from worms to humans. The protein of 413 amino acids contains a central coiled-coil domain, possibly the region that binds to clusterin. Cluap1 expression is highest in the nucleus and gradually increases during late S to G2/M phases of the cell cycle and returns to the basal level in the G0/G1 phases. In addition, it is upregulated in colon cancer tissues compared to corresponding non-cancerous mucosa. It thus plays a crucial role in the life of the cell.


Pssm-ID: 463013 [Multi-domain]  Cd Length: 268  Bit Score: 161.21  E-value: 1.18e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468055602   1 MRIAIKDLLAQVQKTKDLLNNVASDEANLEAKIEKRKLELERNRKRLQTLQSVRPAFMDEYEKVEEDLQKQYDVYLEKFR 80
Cdd:pfam10234 170 LKEAIKNVAAEIEQTQKQLENLASDEANLEAKIEKKKQELERNQKRLQTLQSVRPAFMDEYEKLEEELQKLYEEYVEKFR 249
                          90
                  ....*....|....*....
gi 2468055602  81 NLAYLEQQLEDHHRMEQER 99
Cdd:pfam10234 250 NLSYLEHQLEKYNKAEQER 268
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
1-143 5.28e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 37.73  E-value: 5.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468055602    1 MRIAIKDLLAQVQKTKDLLNNVASDEANLEAKIEKRKLELERNRKRLQTLQSVRPAFMDEYEKVEEDLQKQYdvYLEKFR 80
Cdd:TIGR02168  363 LEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAE--LKELQA 440
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2468055602   81 NLAYLEQQLED---HHRMEQERFEEAENTLRLMQNKLKEEEKRLLKSGSNDDSDIDIQEDDESDSE 143
Cdd:TIGR02168  441 ELEELEEELEElqeELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSE 506
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
5-121 9.58e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 37.22  E-value: 9.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468055602   5 IKDLLAQVQKTKDLLNNVASDEANLEAKIEKRKLELERNRKRLQTLQSvrpafmDEYEKVEE--DLQKQYDVYLEKFRNL 82
Cdd:COG1196   241 LEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQA------EEYELLAElaRLEQDIARLEERRREL 314
                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2468055602  83 AYLEQQLEDHHRMEQERFEEAENTLRLMQNKLKEEEKRL 121
Cdd:COG1196   315 EERLEELEEELAELEEELEELEEELEELEEELEEAEEEL 353
 
Name Accession Description Interval E-value
Cluap1 pfam10234
Clusterin-associated protein-1; This protein is conserved from worms to humans. The protein of ...
1-99 1.18e-48

Clusterin-associated protein-1; This protein is conserved from worms to humans. The protein of 413 amino acids contains a central coiled-coil domain, possibly the region that binds to clusterin. Cluap1 expression is highest in the nucleus and gradually increases during late S to G2/M phases of the cell cycle and returns to the basal level in the G0/G1 phases. In addition, it is upregulated in colon cancer tissues compared to corresponding non-cancerous mucosa. It thus plays a crucial role in the life of the cell.


Pssm-ID: 463013 [Multi-domain]  Cd Length: 268  Bit Score: 161.21  E-value: 1.18e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468055602   1 MRIAIKDLLAQVQKTKDLLNNVASDEANLEAKIEKRKLELERNRKRLQTLQSVRPAFMDEYEKVEEDLQKQYDVYLEKFR 80
Cdd:pfam10234 170 LKEAIKNVAAEIEQTQKQLENLASDEANLEAKIEKKKQELERNQKRLQTLQSVRPAFMDEYEKLEEELQKLYEEYVEKFR 249
                          90
                  ....*....|....*....
gi 2468055602  81 NLAYLEQQLEDHHRMEQER 99
Cdd:pfam10234 250 NLSYLEHQLEKYNKAEQER 268
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
1-143 5.28e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 37.73  E-value: 5.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468055602    1 MRIAIKDLLAQVQKTKDLLNNVASDEANLEAKIEKRKLELERNRKRLQTLQSVRPAFMDEYEKVEEDLQKQYdvYLEKFR 80
Cdd:TIGR02168  363 LEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAE--LKELQA 440
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2468055602   81 NLAYLEQQLED---HHRMEQERFEEAENTLRLMQNKLKEEEKRLLKSGSNDDSDIDIQEDDESDSE 143
Cdd:TIGR02168  441 ELEELEEELEElqeELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSE 506
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
5-121 9.58e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 37.22  E-value: 9.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468055602   5 IKDLLAQVQKTKDLLNNVASDEANLEAKIEKRKLELERNRKRLQTLQSvrpafmDEYEKVEE--DLQKQYDVYLEKFRNL 82
Cdd:COG1196   241 LEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQA------EEYELLAElaRLEQDIARLEERRREL 314
                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2468055602  83 AYLEQQLEDHHRMEQERFEEAENTLRLMQNKLKEEEKRL 121
Cdd:COG1196   315 EERLEELEEELAELEEELEELEEELEELEEELEEAEEEL 353
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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