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Conserved domains on  [gi|4503561|ref|NP_001415|]
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epithelial membrane protein 2 [Homo sapiens]

Protein Classification

PMP-22/EMP/MP20 family protein( domain architecture ID 10467089)

PMP-22/EMP/MP20 family tetraspan membrane protein similar to human claudin-9 (hCLDN-9) which is highly expressed in the inner ear, essential for hearing and a high-affinity receptor of CpE

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PMP22_Claudin pfam00822
PMP-22/EMP/MP20/Claudin family;
1-160 7.40e-59

PMP-22/EMP/MP20/Claudin family;


:

Pssm-ID: 395662  Cd Length: 162  Bit Score: 180.65  E-value: 7.40e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503561      1 MLVLLAFIIAFHITSAALLFIATVDNAWWVGDEF----FADVWRICTNNTNCTVINDS-FQEYSTLQAVQATMILSTILC 75
Cdd:pfam00822   1 MLVLLLGFIVSHIAWVILLFVATIPDQWKVSRYVgaaaSAGLWRNCTTQSCTGQISCKvLELNDALQAVQALMILSIILG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503561     76 CIAFFIFVLQLFRLKQGERFVLTSIIQLMSCLCVMIAASIYTDRREDIHDKNAKFypvTREGSYGYSYILAWVAFACTFI 155
Cdd:pfam00822  81 IISLIVFFFQLFTMRKGGRFKLAGIIFLVSGLCVLVGASIYTSRIATDFGNPFTP---NRKYSFGYSFILGWVAFALAFI 157


                  ....*
gi 4503561    156 SGMMY 160
Cdd:pfam00822 158 GGVLY 162
 
Name Accession Description Interval E-value
PMP22_Claudin pfam00822
PMP-22/EMP/MP20/Claudin family;
1-160 7.40e-59

PMP-22/EMP/MP20/Claudin family;


Pssm-ID: 395662  Cd Length: 162  Bit Score: 180.65  E-value: 7.40e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503561      1 MLVLLAFIIAFHITSAALLFIATVDNAWWVGDEF----FADVWRICTNNTNCTVINDS-FQEYSTLQAVQATMILSTILC 75
Cdd:pfam00822   1 MLVLLLGFIVSHIAWVILLFVATIPDQWKVSRYVgaaaSAGLWRNCTTQSCTGQISCKvLELNDALQAVQALMILSIILG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503561     76 CIAFFIFVLQLFRLKQGERFVLTSIIQLMSCLCVMIAASIYTDRREDIHDKNAKFypvTREGSYGYSYILAWVAFACTFI 155
Cdd:pfam00822  81 IISLIVFFFQLFTMRKGGRFKLAGIIFLVSGLCVLVGASIYTSRIATDFGNPFTP---NRKYSFGYSFILGWVAFALAFI 157


                  ....*
gi 4503561    156 SGMMY 160
Cdd:pfam00822 158 GGVLY 162
 
Name Accession Description Interval E-value
PMP22_Claudin pfam00822
PMP-22/EMP/MP20/Claudin family;
1-160 7.40e-59

PMP-22/EMP/MP20/Claudin family;


Pssm-ID: 395662  Cd Length: 162  Bit Score: 180.65  E-value: 7.40e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503561      1 MLVLLAFIIAFHITSAALLFIATVDNAWWVGDEF----FADVWRICTNNTNCTVINDS-FQEYSTLQAVQATMILSTILC 75
Cdd:pfam00822   1 MLVLLLGFIVSHIAWVILLFVATIPDQWKVSRYVgaaaSAGLWRNCTTQSCTGQISCKvLELNDALQAVQALMILSIILG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503561     76 CIAFFIFVLQLFRLKQGERFVLTSIIQLMSCLCVMIAASIYTDRREDIHDKNAKFypvTREGSYGYSYILAWVAFACTFI 155
Cdd:pfam00822  81 IISLIVFFFQLFTMRKGGRFKLAGIIFLVSGLCVLVGASIYTSRIATDFGNPFTP---NRKYSFGYSFILGWVAFALAFI 157


                  ....*
gi 4503561    156 SGMMY 160
Cdd:pfam00822 158 GGVLY 162
Claudin_2 pfam13903
PMP-22/EMP/MP20/Claudin tight junction; Members of this family are claudins, that form tight ...
 13-161 1.71e-04

PMP-22/EMP/MP20/Claudin tight junction; Members of this family are claudins, that form tight junctions between cells.


Pssm-ID: 372799 [Multi-domain]  Cd Length: 191  Bit Score: 40.10  E-value: 1.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503561     13 ITSAALLFIATVDNAWW---VGDEFFAD---------VWRICTNNTNCTVIND-----------------------SFQE 57
Cdd:pfam13903   1 ILAFALLLIAFATDYWLvldVALTGINNytclfahlgLWRHCFKSEVDVDSDNqtrffgclnqvpnpfptfeeeivSFSV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503561     58 YSTL---QAVQATMILSTILCCIAFFIFVLQLFRLKQGeRFVLTSIIQLMSCLCVMIAASIY----TDRREDIHDKNAKF 130
Cdd:pfam13903  81 TSLPgltRFVQAFAILSLVLIVCGVVCGLLALPKQSVF-LLLAAGILFLLSGVLGLLGVIVFgqsvKLVFEEYFRQWMPE 159

                         170       180       190
                  ....*....|....*....|....*....|.
gi 4503561    131 YPVTREGSYGYSYILAWVAFACTFISGMMYL 161
Cdd:pfam13903 160 HQNNVRISFGWSFALAWAGVVLSLLAGLLFL 190
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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