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Conserved domains on  [gi|4557663|ref|NP_001542|]
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immunoglobulin-binding protein 1 isoform 1 [Homo sapiens]

Protein Classification

IGBP1/TAP42 family protein( domain architecture ID 10514489)

IGBP1/TAP42 family protein similar to human immunoglobulin-binding protein 1 (IGBP1) that is involved in regulation of the catalytic activity of the phosphatases PP2A, PP4 and PP6, and to Saccharomyces cerevisiae type 2A phosphatase-associated protein 42 (TAP42) that is involved in negative regulation of the TOR signaling pathway in response to the available nitrogen source type

CATH:  1.25.40.540
Gene Ontology:  GO:0035303|GO:0051721
PubMed:  11741537|9441740
SCOP:  4004504

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TAP42 pfam04177
TAP42-like family; The TOR signalling pathway activates a cell-growth program in response to ...
 12-329 1.07e-100

TAP42-like family; The TOR signalling pathway activates a cell-growth program in response to nutrients. TIP41 (pfam04176) interacts with TAP42 and negatively regulates the TOR signaling pathway.


:

Pssm-ID: 461209  Cd Length: 305  Bit Score: 298.75  E-value: 1.07e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557663     12 LPELFETGRQLLDEVEvATEPAGSRIVQEKVFKGLDLLEKAAEMLSQLDLFSRNEDLEEIASTDLKYLLVPAFQGALTMK 91
Cdd:pfam04177   1 LSELFDSALKLYEELE-NSTPTNSPEYQDKVKSAIALLELCTKLVSQLSLFSSNETLEDISTSDLKYLLVPYYLGELTQK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557663     92 QVN-PSKRLDHLQRAREHFINYLTQCHCYHVAEFELPKTMNNSAENHTANSSMAYP--SLVAMASQRQAKIQRYKQKKEL 168
Cdd:pfam04177  80 LQTdPEDRLEVLKRAREYYEDFLKRLEDYELLPKEDKKLLESFSSENYSELPELFStaSTSDAAARREEKIARFKREKEL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557663    169 EHRLSAMKSAVES--GQADDERVREYYLLHLQRWIDISLEEIESIDQEIKILRERdssreastsnssrqERPPVKPFIL- 245
Cdd:pfam04177 160 EQKLEELKKRVESrsGQEDEEVVRELYLTQLKLAILKAFQELESIEQELEILEMA--------------PGKPLRPFTIl 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557663    246 -TRNMAQAKVFGAGYpSLPTMTVSDWYEQHRKYG-ALPDQGIAKAAPEEfrkaaQQQEEQEEKEEEDDEQTLHRAREWDD 323
Cdd:pfam04177 226 sTREELQAKVFGPGH-SLPTMTVDEYLEEERRRGgIIEGGGEASAAEPE-----EEEEEDEEDDEEKADEETYKAREWDE 299


                  ....*.
gi 4557663    324 WKDTHP 329
Cdd:pfam04177 300 FKDDNP 305
 
Name Accession Description Interval E-value
TAP42 pfam04177
TAP42-like family; The TOR signalling pathway activates a cell-growth program in response to ...
 12-329 1.07e-100

TAP42-like family; The TOR signalling pathway activates a cell-growth program in response to nutrients. TIP41 (pfam04176) interacts with TAP42 and negatively regulates the TOR signaling pathway.


Pssm-ID: 461209  Cd Length: 305  Bit Score: 298.75  E-value: 1.07e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557663     12 LPELFETGRQLLDEVEvATEPAGSRIVQEKVFKGLDLLEKAAEMLSQLDLFSRNEDLEEIASTDLKYLLVPAFQGALTMK 91
Cdd:pfam04177   1 LSELFDSALKLYEELE-NSTPTNSPEYQDKVKSAIALLELCTKLVSQLSLFSSNETLEDISTSDLKYLLVPYYLGELTQK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557663     92 QVN-PSKRLDHLQRAREHFINYLTQCHCYHVAEFELPKTMNNSAENHTANSSMAYP--SLVAMASQRQAKIQRYKQKKEL 168
Cdd:pfam04177  80 LQTdPEDRLEVLKRAREYYEDFLKRLEDYELLPKEDKKLLESFSSENYSELPELFStaSTSDAAARREEKIARFKREKEL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557663    169 EHRLSAMKSAVES--GQADDERVREYYLLHLQRWIDISLEEIESIDQEIKILRERdssreastsnssrqERPPVKPFIL- 245
Cdd:pfam04177 160 EQKLEELKKRVESrsGQEDEEVVRELYLTQLKLAILKAFQELESIEQELEILEMA--------------PGKPLRPFTIl 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557663    246 -TRNMAQAKVFGAGYpSLPTMTVSDWYEQHRKYG-ALPDQGIAKAAPEEfrkaaQQQEEQEEKEEEDDEQTLHRAREWDD 323
Cdd:pfam04177 226 sTREELQAKVFGPGH-SLPTMTVDEYLEEERRRGgIIEGGGEASAAEPE-----EEEEEDEEDDEEKADEETYKAREWDE 299


                  ....*.
gi 4557663    324 WKDTHP 329
Cdd:pfam04177 300 FKDDNP 305
 
Name Accession Description Interval E-value
TAP42 pfam04177
TAP42-like family; The TOR signalling pathway activates a cell-growth program in response to ...
 12-329 1.07e-100

TAP42-like family; The TOR signalling pathway activates a cell-growth program in response to nutrients. TIP41 (pfam04176) interacts with TAP42 and negatively regulates the TOR signaling pathway.


Pssm-ID: 461209  Cd Length: 305  Bit Score: 298.75  E-value: 1.07e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557663     12 LPELFETGRQLLDEVEvATEPAGSRIVQEKVFKGLDLLEKAAEMLSQLDLFSRNEDLEEIASTDLKYLLVPAFQGALTMK 91
Cdd:pfam04177   1 LSELFDSALKLYEELE-NSTPTNSPEYQDKVKSAIALLELCTKLVSQLSLFSSNETLEDISTSDLKYLLVPYYLGELTQK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557663     92 QVN-PSKRLDHLQRAREHFINYLTQCHCYHVAEFELPKTMNNSAENHTANSSMAYP--SLVAMASQRQAKIQRYKQKKEL 168
Cdd:pfam04177  80 LQTdPEDRLEVLKRAREYYEDFLKRLEDYELLPKEDKKLLESFSSENYSELPELFStaSTSDAAARREEKIARFKREKEL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557663    169 EHRLSAMKSAVES--GQADDERVREYYLLHLQRWIDISLEEIESIDQEIKILRERdssreastsnssrqERPPVKPFIL- 245
Cdd:pfam04177 160 EQKLEELKKRVESrsGQEDEEVVRELYLTQLKLAILKAFQELESIEQELEILEMA--------------PGKPLRPFTIl 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557663    246 -TRNMAQAKVFGAGYpSLPTMTVSDWYEQHRKYG-ALPDQGIAKAAPEEfrkaaQQQEEQEEKEEEDDEQTLHRAREWDD 323
Cdd:pfam04177 226 sTREELQAKVFGPGH-SLPTMTVDEYLEEERRRGgIIEGGGEASAAEPE-----EEEEEDEEDDEEKADEETYKAREWDE 299


                  ....*.
gi 4557663    324 WKDTHP 329
Cdd:pfam04177 300 FKDDNP 305
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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