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Conserved domains on  [gi|4504653|ref|NP_001553|]
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interleukin-18 isoform 1 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
beta-trefoil_IL18 cd23298
beta-trefoil domain found in interleukin-18 (IL-18) and similar proteins; IL-18, also called ...
 42-189 2.66e-52

beta-trefoil domain found in interleukin-18 (IL-18) and similar proteins; IL-18, also called Iboctadekin, or interferon gamma-inducing factor, or IFN-gamma-inducing factor, or interleukin-1 gamma, or IL-1 gamma, is a proinflammatory cytokine primarily involved in polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, it forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. IL-18 works synergistically with IL12/interleukin-12 to induce IFN-gamma synthesis from Th1 cells and natural killer (NK) cells. IL-18 contains a beta-trefoil domain, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


:

Pssm-ID: 466780  Cd Length: 149  Bit Score: 164.31  E-value: 2.66e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504653   42 ESKLSVIRNLNDQVLFIDQGNRPLFEDMTDSDCrdNAPRTIFIISMYKDS-QPRGMAVTISV-KCEKISTLSC-ENKIIS 118
Cdd:cd23298   1 KSKTSIIRNKDNKFLVLDPDGQFVFEDLTDQEL--NAPDCKFTIQIYKDTsPPRGLPVALYVkKDGKTYVLCCeENKEIR 78

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4504653  119 FKEMNPPDNIKDTKSDIIFFQRSVPGHDNKMQFESSSYEGYFLACEKERDLFKLILKKEDELGDRSIMFTV 189
Cdd:cd23298  79 FKEMDLPDDIEGTKSDAIFYQKKFPGGTNKYKFESSLYPGYFLAFEPENDLFKLVLKKKDDEVDETCEFTV 149
 
Name Accession Description Interval E-value
beta-trefoil_IL18 cd23298
beta-trefoil domain found in interleukin-18 (IL-18) and similar proteins; IL-18, also called ...
 42-189 2.66e-52

beta-trefoil domain found in interleukin-18 (IL-18) and similar proteins; IL-18, also called Iboctadekin, or interferon gamma-inducing factor, or IFN-gamma-inducing factor, or interleukin-1 gamma, or IL-1 gamma, is a proinflammatory cytokine primarily involved in polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, it forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. IL-18 works synergistically with IL12/interleukin-12 to induce IFN-gamma synthesis from Th1 cells and natural killer (NK) cells. IL-18 contains a beta-trefoil domain, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 466780  Cd Length: 149  Bit Score: 164.31  E-value: 2.66e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504653   42 ESKLSVIRNLNDQVLFIDQGNRPLFEDMTDSDCrdNAPRTIFIISMYKDS-QPRGMAVTISV-KCEKISTLSC-ENKIIS 118
Cdd:cd23298   1 KSKTSIIRNKDNKFLVLDPDGQFVFEDLTDQEL--NAPDCKFTIQIYKDTsPPRGLPVALYVkKDGKTYVLCCeENKEIR 78

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4504653  119 FKEMNPPDNIKDTKSDIIFFQRSVPGHDNKMQFESSSYEGYFLACEKERDLFKLILKKEDELGDRSIMFTV 189
Cdd:cd23298  79 FKEMDLPDDIEGTKSDAIFYQKKFPGGTNKYKFESSLYPGYFLAFEPENDLFKLVLKKKDDEVDETCEFTV 149
IL1 pfam00340
Interleukin-1 / 18; This family includes interleukin-1 and interleukin-18.
 73-185 1.87e-36

Interleukin-1 / 18; This family includes interleukin-1 and interleukin-18.


Pssm-ID: 395269  Cd Length: 119  Bit Score: 123.33  E-value: 1.87e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504653     73 DCRDNAPRTIFIISMYK-DSQPRGMAVTISVKCEKIsTLSCENK---IISFKEMNPPDNIKDTKSDIIF-FQRSVPGHDN 147
Cdd:pfam00340   2 QGQNLNLEVKFDMSFYKgDSDDSKIPVTLGIKGKKL-YLSCVNKdepVLQLEEVNIPKLIKNKESDKRFfFIRSESKNYV 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 4504653    148 KmqFESSSYEGYFLACEKERDLFKLILK---KEDELGDRSI 185
Cdd:pfam00340  81 E--FESAAYPGWFIATKQEEDLPVFLVNtagGQDSITDFQI 119
 
Name Accession Description Interval E-value
beta-trefoil_IL18 cd23298
beta-trefoil domain found in interleukin-18 (IL-18) and similar proteins; IL-18, also called ...
 42-189 2.66e-52

beta-trefoil domain found in interleukin-18 (IL-18) and similar proteins; IL-18, also called Iboctadekin, or interferon gamma-inducing factor, or IFN-gamma-inducing factor, or interleukin-1 gamma, or IL-1 gamma, is a proinflammatory cytokine primarily involved in polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, it forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. IL-18 works synergistically with IL12/interleukin-12 to induce IFN-gamma synthesis from Th1 cells and natural killer (NK) cells. IL-18 contains a beta-trefoil domain, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 466780  Cd Length: 149  Bit Score: 164.31  E-value: 2.66e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504653   42 ESKLSVIRNLNDQVLFIDQGNRPLFEDMTDSDCrdNAPRTIFIISMYKDS-QPRGMAVTISV-KCEKISTLSC-ENKIIS 118
Cdd:cd23298   1 KSKTSIIRNKDNKFLVLDPDGQFVFEDLTDQEL--NAPDCKFTIQIYKDTsPPRGLPVALYVkKDGKTYVLCCeENKEIR 78

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4504653  119 FKEMNPPDNIKDTKSDIIFFQRSVPGHDNKMQFESSSYEGYFLACEKERDLFKLILKKEDELGDRSIMFTV 189
Cdd:cd23298  79 FKEMDLPDDIEGTKSDAIFYQKKFPGGTNKYKFESSLYPGYFLAFEPENDLFKLVLKKKDDEVDETCEFTV 149
IL1 pfam00340
Interleukin-1 / 18; This family includes interleukin-1 and interleukin-18.
 73-185 1.87e-36

Interleukin-1 / 18; This family includes interleukin-1 and interleukin-18.


Pssm-ID: 395269  Cd Length: 119  Bit Score: 123.33  E-value: 1.87e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504653     73 DCRDNAPRTIFIISMYK-DSQPRGMAVTISVKCEKIsTLSCENK---IISFKEMNPPDNIKDTKSDIIF-FQRSVPGHDN 147
Cdd:pfam00340   2 QGQNLNLEVKFDMSFYKgDSDDSKIPVTLGIKGKKL-YLSCVNKdepVLQLEEVNIPKLIKNKESDKRFfFIRSESKNYV 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 4504653    148 KmqFESSSYEGYFLACEKERDLFKLILK---KEDELGDRSI 185
Cdd:pfam00340  81 E--FESAAYPGWFIATKQEEDLPVFLVNtagGQDSITDFQI 119
beta-trefoil_IL1 cd00100
beta-trefoil domain found in the interleukin-1 (IL-1) family of cytokines; The IL-1 family of ...
 42-189 6.22e-25

beta-trefoil domain found in the interleukin-1 (IL-1) family of cytokines; The IL-1 family of cytokines comprises 11 members, including 7 pro-inflammatory agonists (IL-1alpha, IL-1beta, IL-18, IL-33, IL-36alpha, IL-36beta, IL-36gamma) and 4 defined or putative antagonists (IL-1R antagonist (IL-1Ra), IL-36Ra, IL-37, and IL-38) exerting anti-inflammatory activities. These members can have complimentary or distinct biological functions. All family members share a common structure at the C-terminus, which is comprised by of a typical beta-trefoil fold consisting of 12-beta-strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 466776  Cd Length: 145  Bit Score: 94.31  E-value: 6.22e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504653   42 ESKLSVIRNLNDQVLFIDQGNRPLFEDMTDSDCRDnaprtIFIISMYK---DSQPRGMAVTISVKcEKISTLSC----EN 114
Cdd:cd00100   1 EKRNFVIRDSNDKSLYLRGNNELVAEDLSDVEKSA-----KITIYYYKsdsDEDFKGIPVVLNFT-GTNCFLSCvkegDK 74

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4504653  115 KIISFKEMNPPD--NIKDTKSDIIFFQRSVpgHDNKMQFESSSYEGYFLACEKErdlFKLILKKEDElGDRSIMFTV 189
Cdd:cd00100  75 PSLQLEECNKEElkNGDEEEWPFVFYMKAS--HDNTCRFESAAHPGWFICTKKD---QPVGLTKELG-KTEDTDFYF 145
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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