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Conserved domains on  [gi|18765694|ref|NP_001926|]
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dipeptidyl peptidase 4 isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DPPIV_N pfam00930
Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region ...
 108-478 6.64e-127

Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region to the N-terminal side of the active site. The Prosite motif does not correspond to this Pfam entry.


:

Pssm-ID: 395744 [Multi-domain]  Cd Length: 352  Bit Score: 382.44  E-value: 6.64e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18765694   108 SPDGQFILLEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNLPSYRITW 187
Cdd:pfam00930   1 SPDGKYLLLATNYTKNWRHSYTADYYIYDLETNRVEPLPPGEGKIQDAKWSPDGDRLAFVRDNNLYVRELATGKEIQITS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18765694   188 TGkEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDESLQyPKTVRVPYPKAGAVNPTVK 267
Cdd:pfam00930  81 DG-SDGIFNGVADWVYEEEVLGSNSAVWWSPDGSRLAFLRFDESEVPIITLPYYTDEGPG-PEVREIKYPKAGAPNPTVE 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18765694   268 FFVVNTDSLSSVTnatsiqITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNClvarqhiE 347
Cdd:pfam00930 159 LFVYDLASGKTVE------VVPPDDLSDADYYITRVKWVPDGKLLVQWLNRDQNRLKVVLCDAETGRTVVIL-------E 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18765694   348 MSTTGWVgrFRPSEPHFTL-DGNSFYKiISNEEGYRHICYFQIDKKDCTFITKGTWEVIGIEA--LTSDYLYYISNeyKG 424
Cdd:pfam00930 226 ETSDGWV--ELHQDPHFIKrDGSGFLW-ISERDGYNHLYLYDLDGKSPIQLTSGNWEVTSILGvdETRDLVYFTAT--ED 300

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 18765694   425 MPGGRNLYKIQLSDYTKVTCLSCELNPErcqYYSVSFSKEAKYYQLRCSGPGLP 478
Cdd:pfam00930 301 SPTERHLYSVSLDSGGEPTCLTDDSGDH---DYSASFSPNGSYYVLTYSGPDTP 351
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
559-763 1.56e-64

Prolyl oligopeptidase family;


:

Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 214.02  E-value: 1.56e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18765694   559 FRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSM 638
Cdd:pfam00326   1 PSFSWNAQLLADRGYVVAIANGRGSGGYGEAFHDAGKGDLGQNEFDDFIAAAEYLIEQGYTDPDRLAIWGGSYGGYLTGA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18765694   639 VLGSGSGVFKCGIAVAPVSRWEYYDS----VYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQ-VEYLLIHGTADDNVHF 713
Cdd:pfam00326  81 ALNQRPDLFKAAVAHVPVVDWLAYMSdtslPFTERYMEWGNPWDNEEGYDYLSPYSPADNVKVyPPLLLIHGLLDDRVPP 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 18765694   714 QQSAQISKALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCF 763
Cdd:pfam00326 161 WQSLKLVAALQRKGVPFLLLIFPDEGHGIGKPRNKVEEYARELAFLLEYL 210
DPPIV_rep pfam18811
Dipeptidyl peptidase IV (DPP IV) low complexity region; Dipeptidyl peptidase IV includes an ...
 38-58 3.46e-04

Dipeptidyl peptidase IV (DPP IV) low complexity region; Dipeptidyl peptidase IV includes an helical N-terminal region, the pfam00930 domain and the pfam00326 domain, comprising the active site. This Pfam entry represents a sequence that can be repeated in the low complexity region between the helical N-terminus and the DPPIV_N domain.


:

Pssm-ID: 465875  Cd Length: 21  Bit Score: 38.23  E-value: 3.46e-04
                          10        20
                  ....*....|....*....|.
gi 18765694    38 DSRKTYTLTDYLKNTYRLKLY 58
Cdd:pfam18811   1 DSRRTFTLEDYLNNTFRYKSY 21
 
Name Accession Description Interval E-value
DPPIV_N pfam00930
Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region ...
 108-478 6.64e-127

Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region to the N-terminal side of the active site. The Prosite motif does not correspond to this Pfam entry.


Pssm-ID: 395744 [Multi-domain]  Cd Length: 352  Bit Score: 382.44  E-value: 6.64e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18765694   108 SPDGQFILLEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNLPSYRITW 187
Cdd:pfam00930   1 SPDGKYLLLATNYTKNWRHSYTADYYIYDLETNRVEPLPPGEGKIQDAKWSPDGDRLAFVRDNNLYVRELATGKEIQITS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18765694   188 TGkEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDESLQyPKTVRVPYPKAGAVNPTVK 267
Cdd:pfam00930  81 DG-SDGIFNGVADWVYEEEVLGSNSAVWWSPDGSRLAFLRFDESEVPIITLPYYTDEGPG-PEVREIKYPKAGAPNPTVE 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18765694   268 FFVVNTDSLSSVTnatsiqITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNClvarqhiE 347
Cdd:pfam00930 159 LFVYDLASGKTVE------VVPPDDLSDADYYITRVKWVPDGKLLVQWLNRDQNRLKVVLCDAETGRTVVIL-------E 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18765694   348 MSTTGWVgrFRPSEPHFTL-DGNSFYKiISNEEGYRHICYFQIDKKDCTFITKGTWEVIGIEA--LTSDYLYYISNeyKG 424
Cdd:pfam00930 226 ETSDGWV--ELHQDPHFIKrDGSGFLW-ISERDGYNHLYLYDLDGKSPIQLTSGNWEVTSILGvdETRDLVYFTAT--ED 300

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 18765694   425 MPGGRNLYKIQLSDYTKVTCLSCELNPErcqYYSVSFSKEAKYYQLRCSGPGLP 478
Cdd:pfam00930 301 SPTERHLYSVSLDSGGEPTCLTDDSGDH---DYSASFSPNGSYYVLTYSGPDTP 351
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
559-763 1.56e-64

Prolyl oligopeptidase family;


Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 214.02  E-value: 1.56e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18765694   559 FRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSM 638
Cdd:pfam00326   1 PSFSWNAQLLADRGYVVAIANGRGSGGYGEAFHDAGKGDLGQNEFDDFIAAAEYLIEQGYTDPDRLAIWGGSYGGYLTGA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18765694   639 VLGSGSGVFKCGIAVAPVSRWEYYDS----VYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQ-VEYLLIHGTADDNVHF 713
Cdd:pfam00326  81 ALNQRPDLFKAAVAHVPVVDWLAYMSdtslPFTERYMEWGNPWDNEEGYDYLSPYSPADNVKVyPPLLLIHGLLDDRVPP 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 18765694   714 QQSAQISKALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCF 763
Cdd:pfam00326 161 WQSLKLVAALQRKGVPFLLLIFPDEGHGIGKPRNKVEEYARELAFLLEYL 210
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
522-763 4.04e-50

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 175.59  E-value: 4.04e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18765694 522 TKFWYQMILPPhfdKSKKYPLLLDVYAGPCSQkaDTVFRLnWATYLAStENIIVASFDGRGSGYQGdkimhainRRLGTF 601
Cdd:COG1506   8 TTLPGWLYLPA---DGKKYPVVVYVHGGPGSR--DDSFLP-LAQALAS-RGYAVLAPDYRGYGESA--------GDWGGD 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18765694 602 EVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSV---YTERYMGlpTPED 678
Cdd:COG1506  73 EVDDVLAAIDYLAARPYVDPDRIGIYGHSYGGYMALLAAARHPDRFKAAVALAGVSDLRSYYGTtreYTERLMG--GPWE 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18765694 679 NLDHYRNSTVMSRAENFKqVEYLLIHGTADDNVHFQQSAQISKALVDVGVDFQAMWYTDEDHGIaSSTAHQHIYTHMSHF 758
Cdd:COG1506 151 DPEAYAARSPLAYADKLK-TPLLLIHGEADDRVPPEQAERLYEALKKAGKPVELLVYPGEGHGF-SGAGAPDYLERILDF 228


                ....*
gi 18765694 759 IKQCF 763
Cdd:COG1506 229 LDRHL 233
WD40 COG2319
WD40 repeat [General function prediction only];
94-231 5.07e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.44  E-value: 5.07e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18765694  94 TFDEFGHSINDYSISPDGQFILleynyvkqwrhsyTASYD----IYDLNKRQLITEerIPNNTQWVT---WSPVGHKLAY 166
Cdd:COG2319 115 TLTGHTGAVRSVAFSPDGKTLA-------------SGSADgtvrLWDLATGKLLRT--LTGHSGAVTsvaFSPDGKLLAS 179

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 18765694 167 VWNNDIyVKIepnlpsyritW---TGKEDIIYNGITDWVYeeevfsaysALWWSPNGTFLAYAQFNDT 231
Cdd:COG2319 180 GSDDGT-VRL----------WdlaTGKLLRTLTGHTGAVR---------SVAFSPDGKLLASGSADGT 227
DPPIV_rep pfam18811
Dipeptidyl peptidase IV (DPP IV) low complexity region; Dipeptidyl peptidase IV includes an ...
 38-58 3.46e-04

Dipeptidyl peptidase IV (DPP IV) low complexity region; Dipeptidyl peptidase IV includes an helical N-terminal region, the pfam00930 domain and the pfam00326 domain, comprising the active site. This Pfam entry represents a sequence that can be repeated in the low complexity region between the helical N-terminus and the DPPIV_N domain.


Pssm-ID: 465875  Cd Length: 21  Bit Score: 38.23  E-value: 3.46e-04
                          10        20
                  ....*....|....*....|.
gi 18765694    38 DSRKTYTLTDYLKNTYRLKLY 58
Cdd:pfam18811   1 DSRRTFTLEDYLNNTFRYKSY 21
 
Name Accession Description Interval E-value
DPPIV_N pfam00930
Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region ...
 108-478 6.64e-127

Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region to the N-terminal side of the active site. The Prosite motif does not correspond to this Pfam entry.


Pssm-ID: 395744 [Multi-domain]  Cd Length: 352  Bit Score: 382.44  E-value: 6.64e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18765694   108 SPDGQFILLEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNLPSYRITW 187
Cdd:pfam00930   1 SPDGKYLLLATNYTKNWRHSYTADYYIYDLETNRVEPLPPGEGKIQDAKWSPDGDRLAFVRDNNLYVRELATGKEIQITS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18765694   188 TGkEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDESLQyPKTVRVPYPKAGAVNPTVK 267
Cdd:pfam00930  81 DG-SDGIFNGVADWVYEEEVLGSNSAVWWSPDGSRLAFLRFDESEVPIITLPYYTDEGPG-PEVREIKYPKAGAPNPTVE 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18765694   268 FFVVNTDSLSSVTnatsiqITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNClvarqhiE 347
Cdd:pfam00930 159 LFVYDLASGKTVE------VVPPDDLSDADYYITRVKWVPDGKLLVQWLNRDQNRLKVVLCDAETGRTVVIL-------E 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18765694   348 MSTTGWVgrFRPSEPHFTL-DGNSFYKiISNEEGYRHICYFQIDKKDCTFITKGTWEVIGIEA--LTSDYLYYISNeyKG 424
Cdd:pfam00930 226 ETSDGWV--ELHQDPHFIKrDGSGFLW-ISERDGYNHLYLYDLDGKSPIQLTSGNWEVTSILGvdETRDLVYFTAT--ED 300

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 18765694   425 MPGGRNLYKIQLSDYTKVTCLSCELNPErcqYYSVSFSKEAKYYQLRCSGPGLP 478
Cdd:pfam00930 301 SPTERHLYSVSLDSGGEPTCLTDDSGDH---DYSASFSPNGSYYVLTYSGPDTP 351
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
559-763 1.56e-64

Prolyl oligopeptidase family;


Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 214.02  E-value: 1.56e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18765694   559 FRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSM 638
Cdd:pfam00326   1 PSFSWNAQLLADRGYVVAIANGRGSGGYGEAFHDAGKGDLGQNEFDDFIAAAEYLIEQGYTDPDRLAIWGGSYGGYLTGA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18765694   639 VLGSGSGVFKCGIAVAPVSRWEYYDS----VYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQ-VEYLLIHGTADDNVHF 713
Cdd:pfam00326  81 ALNQRPDLFKAAVAHVPVVDWLAYMSdtslPFTERYMEWGNPWDNEEGYDYLSPYSPADNVKVyPPLLLIHGLLDDRVPP 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 18765694   714 QQSAQISKALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCF 763
Cdd:pfam00326 161 WQSLKLVAALQRKGVPFLLLIFPDEGHGIGKPRNKVEEYARELAFLLEYL 210
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
522-763 4.04e-50

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 175.59  E-value: 4.04e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18765694 522 TKFWYQMILPPhfdKSKKYPLLLDVYAGPCSQkaDTVFRLnWATYLAStENIIVASFDGRGSGYQGdkimhainRRLGTF 601
Cdd:COG1506   8 TTLPGWLYLPA---DGKKYPVVVYVHGGPGSR--DDSFLP-LAQALAS-RGYAVLAPDYRGYGESA--------GDWGGD 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18765694 602 EVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSV---YTERYMGlpTPED 678
Cdd:COG1506  73 EVDDVLAAIDYLAARPYVDPDRIGIYGHSYGGYMALLAAARHPDRFKAAVALAGVSDLRSYYGTtreYTERLMG--GPWE 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18765694 679 NLDHYRNSTVMSRAENFKqVEYLLIHGTADDNVHFQQSAQISKALVDVGVDFQAMWYTDEDHGIaSSTAHQHIYTHMSHF 758
Cdd:COG1506 151 DPEAYAARSPLAYADKLK-TPLLLIHGEADDRVPPEQAERLYEALKKAGKPVELLVYPGEGHGF-SGAGAPDYLERILDF 228


                ....*
gi 18765694 759 IKQCF 763
Cdd:COG1506 229 LDRHL 233
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
566-741 7.63e-11

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 62.68  E-value: 7.63e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18765694 566 YLAstenIIVASFDGRGSGYQGDKIMHAINRrLGTFEVEDQIEAARQF-SKMGFVDNKRIAIWGWSYGGYVTsMVLGSGS 644
Cdd:COG0412  57 YVV----LAPDLYGRGGPGDDPDEARALMGA-LDPELLAADLRAALDWlKAQPEVDAGRVGVVGFCFGGGLA-LLAAARG 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18765694 645 GVFKCGIAvapvsrweYYdsvyterymGLPTPEDNLDHYRNSTVmsraenfkqvEYLLIHGTADDNVHFQQSAQISKALV 724
Cdd:COG0412 131 PDLAAAVS--------FY---------GGLPADDLLDLAARIKA----------PVLLLYGEKDPLVPPEQVAALEAALA 183

                       170
                ....*....|....*..
gi 18765694 725 DVGVDFQAMWYTDEDHG 741
Cdd:COG0412 184 AAGVDVELHVYPGAGHG 200
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 525-722 6.65e-08

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 54.54  E-value: 6.65e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18765694 525 WYqmiLPPhfDKSKKYPLLldVYAGP-CSQKADtvfRLNWATYLAStENIIVASFDGRGSGY-QGDKimhainRRLGTFE 602
Cdd:COG1073  27 LY---LPA--GASKKYPAV--VVAHGnGGVKEQ---RALYAQRLAE-LGFNVLAFDYRGYGEsEGEP------REEGSPE 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18765694 603 VEDqIEAARQF-SKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVfKCGIAVAPVS--------RWEYYDSVYTERYMGL 673
Cdd:COG1073  90 RRD-ARAAVDYlRTLPGVDPERIGLLGISLGGGYALNAAATDPRV-KAVILDSPFTsledlaaqRAKEARGAYLPGVPYL 167

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 18765694 674 PTPEdnldhyRNSTVMSRAENFKQVEY-----LLIHGTADDNVHFQQSAQISKA 722
Cdd:COG1073 168 PNVR------LASLLNDEFDPLAKIEKisrplLFIHGEKDEAVPFYMSEDLYEA 215
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
563-761 3.29e-06

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 48.84  E-value: 3.29e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18765694 563 WATYLAStENIIVASFDGRGSGYQGdkimhainRRLGTFE-VEDQIEAARQFskMGFV---DNKRIAIWGWSYGGYVTSM 638
Cdd:COG2267  47 LAEALAA-AGYAVLAFDLRGHGRSD--------GPRGHVDsFDDYVDDLRAA--LDALrarPGLPVVLLGHSMGGLIALL 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18765694 639 VLGSGSGVFKCGIAVAPvsrweyydsvyteRYMGLPTPEDNLDHYRNSTVMSRAENFKQ-VeyLLIHGTADDNVHFQQSA 717
Cdd:COG2267 116 YAARYPDRVAGLVLLAP-------------AYRADPLLGPSARWLRALRLAEALARIDVpV--LVLHGGADRVVPPEAAR 180

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 18765694 718 QISKALVDvgvDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQ 761
Cdd:COG2267 181 RLAARLSP---DVELVLLPGARHELLNEPAREEVLAAILAWLER 221
WD40 COG2319
WD40 repeat [General function prediction only];
94-231 5.07e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.44  E-value: 5.07e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18765694  94 TFDEFGHSINDYSISPDGQFILleynyvkqwrhsyTASYD----IYDLNKRQLITEerIPNNTQWVT---WSPVGHKLAY 166
Cdd:COG2319 115 TLTGHTGAVRSVAFSPDGKTLA-------------SGSADgtvrLWDLATGKLLRT--LTGHSGAVTsvaFSPDGKLLAS 179

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 18765694 167 VWNNDIyVKIepnlpsyritW---TGKEDIIYNGITDWVYeeevfsaysALWWSPNGTFLAYAQFNDT 231
Cdd:COG2319 180 GSDDGT-VRL----------WdlaTGKLLRTLTGHTGAVR---------SVAFSPDGKLLASGSADGT 227
WD40 COG2319
WD40 repeat [General function prediction only];
94-231 5.11e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.44  E-value: 5.11e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18765694  94 TFDEFGHSINDYSISPDGQFILleynyvkqwrhsyTASYD----IYDLNKRQLITeeRIPNNTQWVT---WSPVGHKLA- 165
Cdd:COG2319 199 TLTGHTGAVRSVAFSPDGKLLA-------------SGSADgtvrLWDLATGKLLR--TLTGHSGSVRsvaFSPDGRLLAs 263

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 18765694 166 -------YVWNNDiyvkiepnlpsyritwTGKEDIIYNGITDWVYeeevfsaysALWWSPNGTFLAYAQFNDT 231
Cdd:COG2319 264 gsadgtvRLWDLA----------------TGELLRTLTGHSGGVN---------SVAFSPDGKLLASGSDDGT 311
WD40 COG2319
WD40 repeat [General function prediction only];
94-226 9.23e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 45.67  E-value: 9.23e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18765694  94 TFDEFGHSINDYSISPDGQFILleynyvkqwrhsyTASYD----IYDLNKRQLITEERIPNNTQW-VTWSPVGHKLA--- 165
Cdd:COG2319 283 TLTGHSGGVNSVAFSPDGKLLA-------------SGSDDgtvrLWDLATGKLLRTLTGHTGAVRsVAFSPDGKTLAsgs 349

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 18765694 166 -----YVWNNDiyvkiepnlpsyritwTGKEDIIYNGITDWVYeeevfsaysALWWSPNGTFLAYA 226
Cdd:COG2319 350 ddgtvRLWDLA----------------TGELLRTLTGHTGAVT---------SVAFSPDGRTLASG 390
WD40 COG2319
WD40 repeat [General function prediction only];
99-224 1.01e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 45.29  E-value: 1.01e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18765694  99 GHS--INDYSISPDGQFILleynyvkqwrhsyTASYD----IYDLNKRQLITeeRIPNNTQWVT---WSPVGHKLAyVWN 169
Cdd:COG2319 160 GHSgaVTSVAFSPDGKLLA-------------SGSDDgtvrLWDLATGKLLR--TLTGHTGAVRsvaFSPDGKLLA-SGS 223

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 18765694 170 NDIYVKIepnlpsyritW---TGKEDIIYNGITDWVYeeevfsaysALWWSPNGTFLA 224
Cdd:COG2319 224 ADGTVRL----------WdlaTGKLLRTLTGHSGSVR---------SVAFSPDGRLLA 262
DPPIV_rep pfam18811
Dipeptidyl peptidase IV (DPP IV) low complexity region; Dipeptidyl peptidase IV includes an ...
 38-58 3.46e-04

Dipeptidyl peptidase IV (DPP IV) low complexity region; Dipeptidyl peptidase IV includes an helical N-terminal region, the pfam00930 domain and the pfam00326 domain, comprising the active site. This Pfam entry represents a sequence that can be repeated in the low complexity region between the helical N-terminus and the DPPIV_N domain.


Pssm-ID: 465875  Cd Length: 21  Bit Score: 38.23  E-value: 3.46e-04
                          10        20
                  ....*....|....*....|.
gi 18765694    38 DSRKTYTLTDYLKNTYRLKLY 58
Cdd:pfam18811   1 DSRRTFTLEDYLNNTFRYKSY 21
YpfH COG0400
Predicted esterase [General function prediction only];
564-764 5.35e-04

Predicted esterase [General function prediction only];


Pssm-ID: 440169 [Multi-domain]  Cd Length: 200  Bit Score: 41.82  E-value: 5.35e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18765694 564 ATYLAStENIIVASFDGRGSGYQGdkiMHA---INRRLGTFEVEDQIEAARQFskMGFVD---------NKRIAIWGWSY 631
Cdd:COG0400  25 APELAL-PGAAVLAPRAPVPEGPG---GRAwfdLSFLEGREDEEGLAAAAEAL--AAFIDelearygidPERIVLAGFSQ 98

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18765694 632 GGYVTSMVLGSGSGVFKCGIAVAPvsrweyydsvyterymGLPTPEDNLDhyrnstvmsRAENFKQVEYLLIHGTADDNV 711
Cdd:COG0400  99 GAAMALSLALRRPELLAGVVALSG----------------YLPGEEALPA---------PEAALAGTPVFLAHGTQDPVI 153

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 18765694 712 HFQQSAQISKALVDVGVDFQAMWYtDEDHGIasstaHQHIYTHMSHFIKQCFS 764
Cdd:COG0400 154 PVERAREAAEALEAAGADVTYREY-PGGHEI-----SPEELADARAWLAERLA 200
WD40 COG2319
WD40 repeat [General function prediction only];
94-226 6.07e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.98  E-value: 6.07e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18765694  94 TFDEFGHSINDYSISPDGQFILleynyvkqwrhsyTASYD----IYDLNKRQLITeeRIPNNTQWVT---WSPVGHKLAy 166
Cdd:COG2319 241 TLTGHSGSVRSVAFSPDGRLLA-------------SGSADgtvrLWDLATGELLR--TLTGHSGGVNsvaFSPDGKLLA- 304

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 18765694 167 VWNNDIYVKIepnlpsyritW---TGKEDIIYNGITDWVYeeevfsaysALWWSPNGTFLAYA 226
Cdd:COG2319 305 SGSDDGTVRL----------WdlaTGKLLRTLTGHTGAVR---------SVAFSPDGKTLASG 348
LpqC COG3509
Acetyl xylan esterase AxeA and related esterases, LpqC family [Carbohydrate transport and ...
 526-719 6.64e-04

Acetyl xylan esterase AxeA and related esterases, LpqC family [Carbohydrate transport and metabolism];


Pssm-ID: 442732 [Multi-domain]  Cd Length: 284  Bit Score: 42.30  E-value: 6.64e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18765694 526 YQMILPPHFDKSKKYPLLLdVYAGpCSQKADTVFRL-NWATyLASTENIIVASFDGRGSGYQG--DKIMHAINRRlGTFE 602
Cdd:COG3509  39 YRLYVPAGYDGGAPLPLVV-ALHG-CGGSAADFAAGtGLNA-LADREGFIVVYPEGTGRAPGRcwNWFDGRDQRR-GRDD 114

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18765694 603 VE--DQI--EAARQFSkmgfVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKcgiAVAPVSrweyydsvyterymGLPtped 678
Cdd:COG3509 115 VAfiAALvdDLAARYG----IDPKRVYVTGLSAGGAMAYRLACEYPDVFA---AVAPVA--------------GLP---- 169

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 18765694 679 nldhYRNSTVMSRAENfKQVEYLLIHGTADDNVHFQQSAQI 719
Cdd:COG3509 170 ----YGAASDAACAPG-RPVPVLVIHGTADPTVPYAGAEET 205
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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