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Conserved domains on  [gi|4503925|ref|NP_002040|]
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erythroid transcription factor [Homo sapiens]

Protein Classification

GATA-type transcription factor( domain architecture ID 10078896)

GATA-type transcription factor binds to the DNA consensus sequence [AT]GATA[AG] and may function as a transcription factor/regulator

CATH:  3.30.50.10
Gene Ontology:  GO:0006355|GO:0008270|GO:0043565
PubMed:  31574210
SCOP:  4003617

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 203-247 1.18e-17

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


:

Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 76.26  E-value: 1.18e-17
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 4503925  203 ECVNCGATATPLWRRD-RTGHYLCNACGLYHKMNGQNRPLIRPKKR 247
Cdd:cd00202   1 ACSNCGTTTTPLWRRGpSGGSTLCNACGLYWKKHGVMRPLSKRKKD 46
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 268-308 1.12e-13

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


:

Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 65.09  E-value: 1.12e-13
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 4503925  268 LWRRN-ASGDPVCNACGLYYKLHQVNRPLTMRK-DGIQTRNRK 308
Cdd:cd00202  12 LWRRGpSGGSTLCNACGLYWKKHGVMRPLSKRKkDQIKRRNRK 54
 
Name Accession Description Interval E-value
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 203-247 1.18e-17

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 76.26  E-value: 1.18e-17
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 4503925  203 ECVNCGATATPLWRRD-RTGHYLCNACGLYHKMNGQNRPLIRPKKR 247
Cdd:cd00202   1 ACSNCGTTTTPLWRRGpSGGSTLCNACGLYWKKHGVMRPLSKRKKD 46
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
202-247 1.56e-14

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 67.44  E-value: 1.56e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 4503925     202 RECVNCGATATPLWRRDRTGH-YLCNACGLYHKMNGQ-NRPLIRPKKR 247
Cdd:smart00401   4 RSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGlKRPLSLKKDG 51
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 268-308 1.12e-13

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 65.09  E-value: 1.12e-13
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 4503925  268 LWRRN-ASGDPVCNACGLYYKLHQVNRPLTMRK-DGIQTRNRK 308
Cdd:cd00202  12 LWRRGpSGGSTLCNACGLYWKKHGVMRPLSKRKkDQIKRRNRK 54
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 204-238 3.04e-13

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 63.49  E-value: 3.04e-13
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 4503925    204 CVNCGATATPLWRRDRTGHY-LCNACGLYHKMNGQN 238
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGLK 36
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
266-302 2.84e-09

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 52.42  E-value: 2.84e-09
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 4503925     266 TTLWRRNASGD-PVCNACGLYYKLH-QVNRPLTMRKDGI 302
Cdd:smart00401  14 TPLWRRGPSGNkTLCNACGLYYKKHgGLKRPLSLKKDGI 52
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
154-313 7.66e-09

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 57.57  E-value: 7.66e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503925  154 SSLPVPNSAYGGPDFSSTFFSPTGSPLNSAAYSSPK---LRGTLPLPPC--------EARECVNCG-ATATPLWRR-DRT 220
Cdd:COG5641 239 SASKLTKSWEERPQGRQLLSDAGSLSPRSNNPKSPLlegLMGSTSLQPVstpklvlpSDKKRSTLTtSTATPLWRRtSDK 318

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503925  221 GHYLCNACGLYHKMNGQNRPLirPKKRLIVSKRAGTQCTNCQTTTTTLWRrnaSGDPVCNACGLYYKLHQVNRPLTMRKD 300
Cdd:COG5641 319 SSFSCNASGSALKPPGSKRPL--LPKPDPNSKRSNATCMNCSSTPTNKIL---SPPTTSNSPGAQVKLPNQTRSTGATKK 393

                       170
                ....*....|...
gi 4503925  301 GIqTRNRKASGKG 313
Cdd:COG5641 394 KI-TRRRMNSGKI 405
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 266-289 1.16e-05

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 41.92  E-value: 1.16e-05
                          10        20
                  ....*....|....*....|....*
gi 4503925    266 TTLWRRNASGDP-VCNACGLYYKLH 289
Cdd:pfam00320   9 TPLWRRGPNGNRtLCNACGLYYKKK 33
 
Name Accession Description Interval E-value
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 203-247 1.18e-17

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 76.26  E-value: 1.18e-17
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 4503925  203 ECVNCGATATPLWRRD-RTGHYLCNACGLYHKMNGQNRPLIRPKKR 247
Cdd:cd00202   1 ACSNCGTTTTPLWRRGpSGGSTLCNACGLYWKKHGVMRPLSKRKKD 46
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
202-247 1.56e-14

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 67.44  E-value: 1.56e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 4503925     202 RECVNCGATATPLWRRDRTGH-YLCNACGLYHKMNGQ-NRPLIRPKKR 247
Cdd:smart00401   4 RSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGlKRPLSLKKDG 51
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 268-308 1.12e-13

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 65.09  E-value: 1.12e-13
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 4503925  268 LWRRN-ASGDPVCNACGLYYKLHQVNRPLTMRK-DGIQTRNRK 308
Cdd:cd00202  12 LWRRGpSGGSTLCNACGLYWKKHGVMRPLSKRKkDQIKRRNRK 54
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 204-238 3.04e-13

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 63.49  E-value: 3.04e-13
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 4503925    204 CVNCGATATPLWRRDRTGHY-LCNACGLYHKMNGQN 238
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGLK 36
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
266-302 2.84e-09

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 52.42  E-value: 2.84e-09
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 4503925     266 TTLWRRNASGD-PVCNACGLYYKLH-QVNRPLTMRKDGI 302
Cdd:smart00401  14 TPLWRRGPSGNkTLCNACGLYYKKHgGLKRPLSLKKDGI 52
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
154-313 7.66e-09

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 57.57  E-value: 7.66e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503925  154 SSLPVPNSAYGGPDFSSTFFSPTGSPLNSAAYSSPK---LRGTLPLPPC--------EARECVNCG-ATATPLWRR-DRT 220
Cdd:COG5641 239 SASKLTKSWEERPQGRQLLSDAGSLSPRSNNPKSPLlegLMGSTSLQPVstpklvlpSDKKRSTLTtSTATPLWRRtSDK 318

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503925  221 GHYLCNACGLYHKMNGQNRPLirPKKRLIVSKRAGTQCTNCQTTTTTLWRrnaSGDPVCNACGLYYKLHQVNRPLTMRKD 300
Cdd:COG5641 319 SSFSCNASGSALKPPGSKRPL--LPKPDPNSKRSNATCMNCSSTPTNKIL---SPPTTSNSPGAQVKLPNQTRSTGATKK 393

                       170
                ....*....|...
gi 4503925  301 GIqTRNRKASGKG 313
Cdd:COG5641 394 KI-TRRRMNSGKI 405
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
204-320 1.52e-06

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 50.25  E-value: 1.52e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503925  204 CVNCGATATPLWRRD-----RTGHYLCNACGLYHKMNGQNRPLIRPKKRLIVS-KRAGTQCTNCQTTTTTLWRRNASGDP 277
Cdd:COG5641 161 CSNCKTTSTPLWRRAssessLPGNNLCNACGLYLKLHGSPRAPISLKSDSIKSrSSRSSHNNNDSNGENANTESIGNSSA 240

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 4503925  278 VCNACGLYYKlhQVNRPLTMRKDGIQTR-NRKASGKGKKKRGSS 320
Cdd:COG5641 241 SKLTKSWEER--PQGRQLLSDAGSLSPRsNNPKSPLLEGLMGST 282
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 266-289 1.16e-05

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 41.92  E-value: 1.16e-05
                          10        20
                  ....*....|....*....|....*
gi 4503925    266 TTLWRRNASGDP-VCNACGLYYKLH 289
Cdd:pfam00320   9 TPLWRRGPNGNRtLCNACGLYYKKK 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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