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Conserved domains on  [gi|4759276|ref|NP_004695|]
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U3 small nucleolar RNA-interacting protein 2 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 139-439 4.31e-47

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 164.43  E-value: 4.31e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759276  139 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIprakkgaegkpPGHSSHVLCMAISSDGKYLASGD 218
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL-----------KGHTGPVRDVAASADGTYLASGS 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759276  219 RSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCV 298
Cdd:cd00200  71 SDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFV 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759276  299 TAGGRDGTVRVWKIPEES-QLVFYGHQGSIDCIHLI-NEEHMVSGADDGSVALWGLSKKRPLALqreahgLRGEPGleqp 376
Cdd:cd00200 151 ASSSQDGTIKLWDLRTGKcVATLTGHTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLSTGKCLGT------LRGHEN---- 220

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4759276  377 fWISSVAALLNTDLVATGSHSSCVRLWQcgegFRQLDLLCDIPLV-GFINSLKFSSSGDFLVAG 439
Cdd:cd00200 221 -GVNSVAFSPDGYLLASGSEDGTIRVWD----LRTGECVQTLSGHtNSVTSLAWSPDGKRLASG 279
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 139-439 4.31e-47

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 164.43  E-value: 4.31e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759276  139 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIprakkgaegkpPGHSSHVLCMAISSDGKYLASGD 218
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL-----------KGHTGPVRDVAASADGTYLASGS 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759276  219 RSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCV 298
Cdd:cd00200  71 SDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFV 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759276  299 TAGGRDGTVRVWKIPEES-QLVFYGHQGSIDCIHLI-NEEHMVSGADDGSVALWGLSKKRPLALqreahgLRGEPGleqp 376
Cdd:cd00200 151 ASSSQDGTIKLWDLRTGKcVATLTGHTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLSTGKCLGT------LRGHEN---- 220

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4759276  377 fWISSVAALLNTDLVATGSHSSCVRLWQcgegFRQLDLLCDIPLV-GFINSLKFSSSGDFLVAG 439
Cdd:cd00200 221 -GVNSVAFSPDGYLLASGSEDGTIRVWD----LRTGECVQTLSGHtNSVTSLAWSPDGKRLASG 279
WD40 COG2319
WD40 repeat [General function prediction only];
132-439 3.23e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 165.47  E-value: 3.23e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759276  132 QAPASADIRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPrakkgaegkppGHSSHVLCMAISSDG 211
Cdd:COG2319 106 DLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLT-----------GHSGAVTSVAFSPDG 174

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759276  212 KYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALdA 291
Cdd:COG2319 175 KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSV-A 253

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759276  292 LSREC-CVTAGGRDGTVRVWKIPEESQLVFY-GHQGSIDCIHLI-NEEHMVSGADDGSVALWGLSKKRPLalqreaHGLR 368
Cdd:COG2319 254 FSPDGrLLASGSADGTVRLWDLATGELLRTLtGHSGGVNSVAFSpDGKLLASGSDDGTVRLWDLATGKLL------RTLT 327

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4759276  369 GEPGleqpfWISSVAALLNTDLVATGSHSSCVRLWQCGEGfrqldlLCDIPLVGF---INSLKFSSSGDFLVAG 439
Cdd:COG2319 328 GHTG-----AVRSVAFSPDGKTLASGSDDGTVRLWDLATG------ELLRTLTGHtgaVTSVAFSPDGRTLASG 390
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 198-404 1.55e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 53.94  E-value: 1.55e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759276   198 HSSHVLC-MAISSDGKYLASGDRSKLILIWEAQSC-------QHLYTFTGHRDAVSGLAFRRGTH-QLYSTSHDRSVKVW 268
Cdd:PLN00181 481 NSSNLVCaIGFDRDGEFFATAGVNKKIKIFECESIikdgrdiHYPVVELASRSKLSGICWNSYIKsQVASSNFEGVVQVW 560

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759276   269 NVAENSYVETLFGHQDAVAALDALSRECCVTAGGR-DGTVRVWKI--------------------PEES----------Q 317
Cdd:PLN00181 561 DVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSdDGSVKLWSInqgvsigtiktkaniccvqfPSESgrslafgsadH 640

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759276   318 LVFY--------------GHQGSIDCIHLINEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEPGLEQPFWISsva 383
Cdd:PLN00181 641 KVYYydlrnpklplctmiGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSMSISGINETPLHSFMGHTNVKNFVGLS--- 717

                        250       260
                 ....*....|....*....|.
gi 4759276   384 alLNTDLVATGSHSSCVRLWQ 404
Cdd:PLN00181 718 --VSDGYIATGSETNEVFVYH 736
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 230-269 2.69e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 2.69e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 4759276     230 SCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWN 269
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
232-269 8.02e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 8.02e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 4759276    232 QHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWN 269
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 139-439 4.31e-47

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 164.43  E-value: 4.31e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759276  139 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIprakkgaegkpPGHSSHVLCMAISSDGKYLASGD 218
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL-----------KGHTGPVRDVAASADGTYLASGS 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759276  219 RSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCV 298
Cdd:cd00200  71 SDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFV 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759276  299 TAGGRDGTVRVWKIPEES-QLVFYGHQGSIDCIHLI-NEEHMVSGADDGSVALWGLSKKRPLALqreahgLRGEPGleqp 376
Cdd:cd00200 151 ASSSQDGTIKLWDLRTGKcVATLTGHTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLSTGKCLGT------LRGHEN---- 220

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4759276  377 fWISSVAALLNTDLVATGSHSSCVRLWQcgegFRQLDLLCDIPLV-GFINSLKFSSSGDFLVAG 439
Cdd:cd00200 221 -GVNSVAFSPDGYLLASGSEDGTIRVWD----LRTGECVQTLSGHtNSVTSLAWSPDGKRLASG 279
WD40 COG2319
WD40 repeat [General function prediction only];
132-439 3.23e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 165.47  E-value: 3.23e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759276  132 QAPASADIRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPrakkgaegkppGHSSHVLCMAISSDG 211
Cdd:COG2319 106 DLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLT-----------GHSGAVTSVAFSPDG 174

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759276  212 KYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALdA 291
Cdd:COG2319 175 KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSV-A 253

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759276  292 LSREC-CVTAGGRDGTVRVWKIPEESQLVFY-GHQGSIDCIHLI-NEEHMVSGADDGSVALWGLSKKRPLalqreaHGLR 368
Cdd:COG2319 254 FSPDGrLLASGSADGTVRLWDLATGELLRTLtGHSGGVNSVAFSpDGKLLASGSDDGTVRLWDLATGKLL------RTLT 327

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4759276  369 GEPGleqpfWISSVAALLNTDLVATGSHSSCVRLWQCGEGfrqldlLCDIPLVGF---INSLKFSSSGDFLVAG 439
Cdd:COG2319 328 GHTG-----AVRSVAFSPDGKTLASGSDDGTVRLWDLATG------ELLRTLTGHtgaVTSVAFSPDGRTLASG 390
WD40 COG2319
WD40 repeat [General function prediction only];
139-404 4.81e-45

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 162.39  E-value: 4.81e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759276  139 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPrakkgaegkppGHSSHVLCMAISSDGKYLASGD 218
Cdd:COG2319 155 LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT-----------GHTGAVRSVAFSPDGKLLASGS 223

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759276  219 RSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALdALSRE-CC 297
Cdd:COG2319 224 ADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSV-AFSPDgKL 302

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759276  298 VTAGGRDGTVRVWKIPEESQL-VFYGHQGSIDCIHLI-NEEHMVSGADDGSVALWGLSKKRPLALqreahgLRGEPGleq 375
Cdd:COG2319 303 LASGSDDGTVRLWDLATGKLLrTLTGHTGAVRSVAFSpDGKTLASGSDDGTVRLWDLATGELLRT------LTGHTG--- 373

                       250       260
                ....*....|....*....|....*....
gi 4759276  376 pfWISSVAALLNTDLVATGSHSSCVRLWQ 404
Cdd:COG2319 374 --AVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 139-404 4.82e-45

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 159.04  E-value: 4.82e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759276  139 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPrakkgaegkppGHSSHVLCMAISSDGKYLASGD 218
Cdd:cd00200  44 LRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLT-----------GHTSYVSSVAFSPDGRILSSSS 112

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759276  219 RSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCV 298
Cdd:cd00200 113 RDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKL 192

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759276  299 TAGGRDGTVRVWKIPEESQL-VFYGHQGSIDCIHLI-NEEHMVSGADDGSVALWGLSKKRPLALqreahgLRGEPGleqp 376
Cdd:cd00200 193 LSSSSDGTIKLWDLSTGKCLgTLRGHENGVNSVAFSpDGYLLASGSEDGTIRVWDLRTGECVQT------LSGHTN---- 262

                       250       260
                ....*....|....*....|....*...
gi 4759276  377 fWISSVAALLNTDLVATGSHSSCVRLWQ 404
Cdd:cd00200 263 -SVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
90-439 1.41e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 152.76  E-value: 1.41e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759276   90 LRQQEEEKAEARAFEEDQVAGRLKEDVLEQRGRLQKLVAKEIQAPASADIRVLRGHQLSITCLVVTPDDSAIFSAAKDCS 169
Cdd:COG2319  22 AAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGT 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759276  170 IIKWSVESGRKLHViprakkgaegkPPGHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAF 249
Cdd:COG2319 102 VRLWDLATGLLLRT-----------LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF 170

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759276  250 RRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALdALSRE-CCVTAGGRDGTVRVWKIPEESQL-VFYGHQGSI 327
Cdd:COG2319 171 SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV-AFSPDgKLLASGSADGTVRLWDLATGKLLrTLTGHSGSV 249

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759276  328 DCIHL-INEEHMVSGADDGSVALWGLSKKRPLALqreahgLRGEPGleqpfWISSVAALLNTDLVATGSHSSCVRLWQCG 406
Cdd:COG2319 250 RSVAFsPDGRLLASGSADGTVRLWDLATGELLRT------LTGHSG-----GVNSVAFSPDGKLLASGSDDGTVRLWDLA 318

                       330       340       350
                ....*....|....*....|....*....|...
gi 4759276  407 EGfRQLDLLcdIPLVGFINSLKFSSSGDFLVAG 439
Cdd:COG2319 319 TG-KLLRTL--TGHTGAVRSVAFSPDGKTLASG 348
WD40 COG2319
WD40 repeat [General function prediction only];
139-353 3.48e-38

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 143.51  E-value: 3.48e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759276  139 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPrakkgaegkppGHSSHVLCMAISSDGKYLASGD 218
Cdd:COG2319 197 LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT-----------GHSGSVRSVAFSPDGRLLASGS 265

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759276  219 RSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALdALSRECCV 298
Cdd:COG2319 266 ADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV-AFSPDGKT 344

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 4759276  299 TA-GGRDGTVRVWKIPEESQL-VFYGHQGSIDCIHL-INEEHMVSGADDGSVALWGLS 353
Cdd:COG2319 345 LAsGSDDGTVRLWDLATGELLrTLTGHTGAVTSVAFsPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
115-456 1.05e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 128.49  E-value: 1.05e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759276  115 DVLEQRGRLQKLVAKEIQAPASADIRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHViprakkgaegk 194
Cdd:COG2319   5 DGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLAT----------- 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759276  195 PPGHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENS 274
Cdd:COG2319  74 LLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGK 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759276  275 YVETLFGHQDAVAALdALS----ReccVTAGGRDGTVRVWKIPEESQL-VFYGHQGSIDCIHLI-NEEHMVSGADDGSVA 348
Cdd:COG2319 154 LLRTLTGHSGAVTSV-AFSpdgkL---LASGSDDGTVRLWDLATGKLLrTLTGHTGAVRSVAFSpDGKLLASGSADGTVR 229

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759276  349 LWGLSKKRPLALqreahgLRGEPGleqpfWISSVAALLNTDLVATGSHSSCVRLWQCGEGfRQLDLLCDIPlvGFINSLK 428
Cdd:COG2319 230 LWDLATGKLLRT------LTGHSG-----SVRSVAFSPDGRLLASGSADGTVRLWDLATG-ELLRTLTGHS--GGVNSVA 295

                       330       340
                ....*....|....*....|....*...
gi 4759276  429 FSSSGDFLVAGvGQEHRLgRWWRIKEAR 456
Cdd:COG2319 296 FSPDGKLLASG-SDDGTV-RLWDLATGK 321
WD40 COG2319
WD40 repeat [General function prediction only];
206-439 6.58e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 82.27  E-value: 6.58e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759276  206 AISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDA 285
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759276  286 VAALDALSRECCVTAGGRDGTVRVWKIPEESQL-VFYGHQGSIDCIHL-INEEHMVSGADDGSVALWGLSKKRPLALqre 363
Cdd:COG2319  81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLrTLTGHTGAVRSVAFsPDGKTLASGSADGTVRLWDLATGKLLRT--- 157

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4759276  364 ahgLRGEPGleqpfWISSVAALLNTDLVATGSHSSCVRLWQCGEGfRQLDLLCDIPlvGFINSLKFSSSGDFLVAG 439
Cdd:COG2319 158 ---LTGHSG-----AVTSVAFSPDGKLLASGSDDGTVRLWDLATG-KLLRTLTGHT--GAVRSVAFSPDGKLLASG 222
WD40 COG2319
WD40 repeat [General function prediction only];
139-230 2.91e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 64.93  E-value: 2.91e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759276  139 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPrakkgaegkppGHSSHVLCMAISSDGKYLASGD 218
Cdd:COG2319 323 LRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLT-----------GHTGAVTSVAFSPDGRTLASGS 391

                        90
                ....*....|..
gi 4759276  219 RSKLILIWEAQS 230
Cdd:COG2319 392 ADGTVRLWDLAT 403
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 198-404 1.55e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 53.94  E-value: 1.55e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759276   198 HSSHVLC-MAISSDGKYLASGDRSKLILIWEAQSC-------QHLYTFTGHRDAVSGLAFRRGTH-QLYSTSHDRSVKVW 268
Cdd:PLN00181 481 NSSNLVCaIGFDRDGEFFATAGVNKKIKIFECESIikdgrdiHYPVVELASRSKLSGICWNSYIKsQVASSNFEGVVQVW 560

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759276   269 NVAENSYVETLFGHQDAVAALDALSRECCVTAGGR-DGTVRVWKI--------------------PEES----------Q 317
Cdd:PLN00181 561 DVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSdDGSVKLWSInqgvsigtiktkaniccvqfPSESgrslafgsadH 640

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759276   318 LVFY--------------GHQGSIDCIHLINEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEPGLEQPFWISsva 383
Cdd:PLN00181 641 KVYYydlrnpklplctmiGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSMSISGINETPLHSFMGHTNVKNFVGLS--- 717

                        250       260
                 ....*....|....*....|.
gi 4759276   384 alLNTDLVATGSHSSCVRLWQ 404
Cdd:PLN00181 718 --VSDGYIATGSETNEVFVYH 736
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 230-269 2.69e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 2.69e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 4759276     230 SCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWN 269
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
232-269 8.02e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 8.02e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 4759276    232 QHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWN 269
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 196-227 2.83e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 2.83e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 4759276     196 PGHSSHVLCMAISSDGKYLASGDRSKLILIWE 227
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
196-227 7.68e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 7.68e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 4759276    196 PGHSSHVLCMAISSDGKYLASGDRSKLILIWE 227
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 139-174 2.54e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 2.54e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 4759276     139 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWS 174
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
139-174 4.42e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 4.42e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 4759276    139 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWS 174
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
276-310 9.34e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 9.34e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 4759276    276 VETLFGHQDAVAALDALSRECCVTAGGRDGTVRVW 310
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 274-311 3.58e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 3.58e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 4759276     274 SYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWK 311
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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