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Conserved domains on  [gi|4826702|ref|NP_004939|]
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desmocollin-1 isoform Dsc1b precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_pro smart01055
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 29-109 5.87e-32

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


:

Pssm-ID: 214999  Cd Length: 87  Bit Score: 119.31  E-value: 5.87e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4826702      29 ACQKVYLRVPSHLQAETLVGKVNLEECLKSASL-IRSSDPAFRILEDGSIYTTHDLILSSERKSFSIFLSDGQRREQQEI 107
Cdd:smart01055   6 SEEKYTFHVPSHLEAGQPLGRVNFEECLGSARLqFESSDPDFRVLEDGTVYATRPVSLSSEKKSFTVLAWDSQGQEKKEI 85


                   ..
gi 4826702     108 KV 109
Cdd:smart01055  86 KV 87
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 249-350 1.81e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 109.71  E-value: 1.81e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4826702  249 FTVPENCRSGTSVGKVTATDLDEPDtlHTRLKYKILQqiPDHPKHFSIHPDTGVITTTTPfLDREKCDTYQLIMEVRDMG 328
Cdd:cd11304   4 VSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVS--GNEDGLFSIDPSTGEITTAKP-LDREEQSSYTLTVTATDGG 78

                        90       100
                ....*....|....*....|..
gi 4826702  329 GQPfgLFNTGTITISLEDENDN 350
Cdd:cd11304  79 GPP--LSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
139-233 8.18e-20

Cadherin domain;


:

Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 84.66  E-value: 8.18e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4826702    139 IPASLMENSL-GPFPQHVQQIQSDAAQNYTIFYSISGPGVDkepfNLFYIEKDTGDIFCTRSIDREKYEQFALYGYATTA 217
Cdd:pfam00028   1 YSASVPENAPvGTEVLTVTATDPDLGPNGRIFYSILGGGPG----GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 4826702    218 DGYAPEYPLPLIIKIE 233
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
485-567 1.80e-16

Cadherin domain;


:

Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.41  E-value: 1.80e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4826702    485 PAGQELLGYKALDPEISSGEGLRYQKL-GDEDNWFEINQHTGDLRTLKVLDRESkfvkNNQYNISVVAVDA--VGRSCTG 561
Cdd:pfam00028  10 PVGTEVLTVTATDPDLGPNGRIFYSILgGGPGGNFRIDPDTGDISTTKPLDRES----IGEYELTVEATDSggPPLSSTA 85


                  ....*.
gi 4826702    562 TLVVHL 567
Cdd:pfam00028  86 TVTITV 91
Cadherin pfam00028
Cadherin domain;
359-449 6.37e-15

Cadherin domain;


:

Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 70.79  E-value: 6.37e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4826702    359 YVTEVEEN-RIDVEILRMKVQDQDLPntPHSKAVYKILQGNENGNFIISTDPntneGVLCVVKPLNYEVNRQVILQVGVI 437
Cdd:pfam00028   1 YSASVPENaPVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90
                  ....*....|..
gi 4826702    438 NEAQFSKAASSQ 449
Cdd:pfam00028  75 DSGGPPLSSTAT 86
CA_like super family cl46864
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 596-667 3.46e-04

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


The actual alignment was detected with superfamily member smart00112:

Pssm-ID: 481204 [Multi-domain]  Cd Length: 81  Bit Score: 40.03  E-value: 3.46e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4826702     596 VDPDGPENGPPFQFFLDNSASKNWNIEEKDGktaILRQRQNLDY---NYYSVPIQIKDRHG--LVATHMLTVRVCDC 667
Cdd:smart00112   3 TDADSGENGKVTYSILSGNDDGLFSIDPETG---EITTTKPLDReeqPEYTLTVEATDGGGppLSSTATVTITVLDV 76
 
Name Accession Description Interval E-value
Cadherin_pro smart01055
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 29-109 5.87e-32

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 214999  Cd Length: 87  Bit Score: 119.31  E-value: 5.87e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4826702      29 ACQKVYLRVPSHLQAETLVGKVNLEECLKSASL-IRSSDPAFRILEDGSIYTTHDLILSSERKSFSIFLSDGQRREQQEI 107
Cdd:smart01055   6 SEEKYTFHVPSHLEAGQPLGRVNFEECLGSARLqFESSDPDFRVLEDGTVYATRPVSLSSEKKSFTVLAWDSQGQEKKEI 85


                   ..
gi 4826702     108 KV 109
Cdd:smart01055  86 KV 87
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 249-350 1.81e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 109.71  E-value: 1.81e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4826702  249 FTVPENCRSGTSVGKVTATDLDEPDtlHTRLKYKILQqiPDHPKHFSIHPDTGVITTTTPfLDREKCDTYQLIMEVRDMG 328
Cdd:cd11304   4 VSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVS--GNEDGLFSIDPSTGEITTAKP-LDREEQSSYTLTVTATDGG 78

                        90       100
                ....*....|....*....|..
gi 4826702  329 GQPfgLFNTGTITISLEDENDN 350
Cdd:cd11304  79 GPP--LSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
249-345 1.52e-25

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 101.22  E-value: 1.52e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4826702    249 FTVPENCRSGTSVGKVTATDLDEPDtlHTRLKYKILQQIPDHpkHFSIHPDTGVITTTTPfLDREKCDTYQLIMEVRDMG 328
Cdd:pfam00028   3 ASVPENAPVGTEVLTVTATDPDLGP--NGRIFYSILGGGPGG--NFRIDPDTGDISTTKP-LDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....*..
gi 4826702    329 GQPfgLFNTGTITISLE 345
Cdd:pfam00028  78 GPP--LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 265-352 6.38e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 90.49  E-value: 6.38e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4826702     265 TATDLDEPDtlHTRLKYKILQQIPDHpkHFSIHPDTGVITTTTPfLDREKCDTYQLIMEVRDMGGQPfgLFNTGTITISL 344
Cdd:smart00112   1 SATDADSGE--NGKVTYSILSGNDDG--LFSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGGPP--LSSTATVTITV 73


                   ....*...
gi 4826702     345 EDENDNPP 352
Cdd:smart00112  74 LDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
139-233 8.18e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 84.66  E-value: 8.18e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4826702    139 IPASLMENSL-GPFPQHVQQIQSDAAQNYTIFYSISGPGVDkepfNLFYIEKDTGDIFCTRSIDREKYEQFALYGYATTA 217
Cdd:pfam00028   1 YSASVPENAPvGTEVLTVTATDPDLGPNGRIFYSILGGGPG----GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 4826702    218 DGYAPEYPLPLIIKIE 233
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
485-567 1.80e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.41  E-value: 1.80e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4826702    485 PAGQELLGYKALDPEISSGEGLRYQKL-GDEDNWFEINQHTGDLRTLKVLDRESkfvkNNQYNISVVAVDA--VGRSCTG 561
Cdd:pfam00028  10 PVGTEVLTVTATDPDLGPNGRIFYSILgGGPGGNFRIDPDTGDISTTKPLDRES----IGEYELTVEATDSggPPLSSTA 85


                  ....*.
gi 4826702    562 TLVVHL 567
Cdd:pfam00028  86 TVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 485-573 2.20e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.04  E-value: 2.20e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4826702  485 PAGQELLGYKALDPEISSGEGLRYQKL-GDEDNWFEINQHTGDLRTLKVLDRESKfvknNQYNISVVAVDAVG--RSCTG 561
Cdd:cd11304  11 PPGTVVLTVSATDPDSGENGEVTYSIVsGNEDGLFSIDPSTGEITTAKPLDREEQ----SSYTLTVTATDGGGppLSSTA 86

                        90
                ....*....|..
gi 4826702  562 TLVVHLDDYNDH 573
Cdd:cd11304  87 TVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
359-449 6.37e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 70.79  E-value: 6.37e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4826702    359 YVTEVEEN-RIDVEILRMKVQDQDLPntPHSKAVYKILQGNENGNFIISTDPntneGVLCVVKPLNYEVNRQVILQVGVI 437
Cdd:pfam00028   1 YSASVPENaPVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90
                  ....*....|..
gi 4826702    438 NEAQFSKAASSQ 449
Cdd:pfam00028  75 DSGGPPLSSTAT 86
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 494-575 3.22e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.53  E-value: 3.22e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4826702     494 KALDPEISSGEGLRYQKL-GDEDNWFEINQHTGDLRTLKVLDRESKfvknNQYNISVVAVDAVG--RSCTGTLVVHLDDY 570
Cdd:smart00112   1 SATDADSGENGKVTYSILsGNDDGLFSIDPETGEITTTKPLDREEQ----PEYTLTVEATDGGGppLSSTATVTITVLDV 76


                   ....*
gi 4826702     571 NDHAP 575
Cdd:smart00112  77 NDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 160-240 2.09e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 66.22  E-value: 2.09e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4826702     160 SDAAQNYTIFYSISGPGVDkepfNLFYIEKDTGDIFCTRSIDREKYEQFALYGYATTADGYAPEYPLPLIIKIEDDNDNA 239
Cdd:smart00112   5 ADSGENGKVTYSILSGNDD----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
gi 4826702     240 P 240
Cdd:smart00112  81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 138-238 1.86e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 63.87  E-value: 1.86e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4826702  138 PIPASLMENSlgPFPQHVQQIQ---SDAAQNYTIFYSISGPGvdkePFNLFYIEKDTGDIFCTRSIDREKYEQFALYGYA 214
Cdd:cd11304   1 SYEVSVPENA--PPGTVVLTVSatdPDSGENGEVTYSIVSGN----EDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTA 74

                        90       100
                ....*....|....*....|....
gi 4826702  215 TTADGYAPEYPLPLIIKIEDDNDN 238
Cdd:cd11304  75 TDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 358-449 6.10e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 62.72  E-value: 6.10e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4826702  358 SYVTEVEEN-RIDVEILRMKVQDQDLPntPHSKAVYKILQGNENGNFIIstDPNTneGVLCVVKPLNYEVNRQVILQVGV 436
Cdd:cd11304   1 SYEVSVPENaPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTA 74

                        90
                ....*....|...
gi 4826702  437 INEAQFSKAASSQ 449
Cdd:cd11304  75 TDGGGPPLSSTAT 87
Cadherin_pro pfam08758
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 31-111 7.15e-06

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 462590  Cd Length: 90  Bit Score: 45.01  E-value: 7.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4826702     31 QKVY-LRVPSHLQAETLVGKVNLEECL-KSASLIRSSDPAFRILEDGSIYTTHDLILSSERKSFSIFLSDGQRREQQEIK 108
Cdd:pfam08758   8 EEVYtFSVPRRLEEGQPLLNVKFNDCTgRKKTLYESSDPRFKVNTDGTVTAKRPVTLHGRQTSFLVHAWDSHGEKMASVK 87


                  ...
gi 4826702    109 VVL 111
Cdd:pfam08758  88 VTV 90
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 376-474 1.10e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 44.26  E-value: 1.10e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4826702     376 KVQDQDLPntPHSKAVYKILQGNENGNFIIstDPNTneGVLCVVKPLNYEVNRQVILQVGVINEAQFSKAASSQtptmct 455
Cdd:smart00112   1 SATDADSG--ENGKVTYSILSGNDDGLFSI--DPET--GEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTAT------ 68

                           90
                   ....*....|....*....
gi 4826702     456 ttVTVKIIDSDEgpecHPP 474
Cdd:smart00112  69 --VTITVLDVND----NAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 596-667 3.46e-04

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 40.03  E-value: 3.46e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4826702     596 VDPDGPENGPPFQFFLDNSASKNWNIEEKDGktaILRQRQNLDY---NYYSVPIQIKDRHG--LVATHMLTVRVCDC 667
Cdd:smart00112   3 TDADSGENGKVTYSILSGNDDGLFSIDPETG---EITTTKPLDReeqPEYTLTVEATDGGGppLSSTATVTITVLDV 76
 
Name Accession Description Interval E-value
Cadherin_pro smart01055
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 29-109 5.87e-32

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 214999  Cd Length: 87  Bit Score: 119.31  E-value: 5.87e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4826702      29 ACQKVYLRVPSHLQAETLVGKVNLEECLKSASL-IRSSDPAFRILEDGSIYTTHDLILSSERKSFSIFLSDGQRREQQEI 107
Cdd:smart01055   6 SEEKYTFHVPSHLEAGQPLGRVNFEECLGSARLqFESSDPDFRVLEDGTVYATRPVSLSSEKKSFTVLAWDSQGQEKKEI 85


                   ..
gi 4826702     108 KV 109
Cdd:smart01055  86 KV 87
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 249-350 1.81e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 109.71  E-value: 1.81e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4826702  249 FTVPENCRSGTSVGKVTATDLDEPDtlHTRLKYKILQqiPDHPKHFSIHPDTGVITTTTPfLDREKCDTYQLIMEVRDMG 328
Cdd:cd11304   4 VSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVS--GNEDGLFSIDPSTGEITTAKP-LDREEQSSYTLTVTATDGG 78

                        90       100
                ....*....|....*....|..
gi 4826702  329 GQPfgLFNTGTITISLEDENDN 350
Cdd:cd11304  79 GPP--LSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
249-345 1.52e-25

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 101.22  E-value: 1.52e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4826702    249 FTVPENCRSGTSVGKVTATDLDEPDtlHTRLKYKILQQIPDHpkHFSIHPDTGVITTTTPfLDREKCDTYQLIMEVRDMG 328
Cdd:pfam00028   3 ASVPENAPVGTEVLTVTATDPDLGP--NGRIFYSILGGGPGG--NFRIDPDTGDISTTKP-LDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....*..
gi 4826702    329 GQPfgLFNTGTITISLE 345
Cdd:pfam00028  78 GPP--LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 265-352 6.38e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 90.49  E-value: 6.38e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4826702     265 TATDLDEPDtlHTRLKYKILQQIPDHpkHFSIHPDTGVITTTTPfLDREKCDTYQLIMEVRDMGGQPfgLFNTGTITISL 344
Cdd:smart00112   1 SATDADSGE--NGKVTYSILSGNDDG--LFSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGGPP--LSSTATVTITV 73


                   ....*...
gi 4826702     345 EDENDNPP 352
Cdd:smart00112  74 LDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
139-233 8.18e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 84.66  E-value: 8.18e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4826702    139 IPASLMENSL-GPFPQHVQQIQSDAAQNYTIFYSISGPGVDkepfNLFYIEKDTGDIFCTRSIDREKYEQFALYGYATTA 217
Cdd:pfam00028   1 YSASVPENAPvGTEVLTVTATDPDLGPNGRIFYSILGGGPG----GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 4826702    218 DGYAPEYPLPLIIKIE 233
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
485-567 1.80e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.41  E-value: 1.80e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4826702    485 PAGQELLGYKALDPEISSGEGLRYQKL-GDEDNWFEINQHTGDLRTLKVLDRESkfvkNNQYNISVVAVDA--VGRSCTG 561
Cdd:pfam00028  10 PVGTEVLTVTATDPDLGPNGRIFYSILgGGPGGNFRIDPDTGDISTTKPLDRES----IGEYELTVEATDSggPPLSSTA 85


                  ....*.
gi 4826702    562 TLVVHL 567
Cdd:pfam00028  86 TVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 485-573 2.20e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.04  E-value: 2.20e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4826702  485 PAGQELLGYKALDPEISSGEGLRYQKL-GDEDNWFEINQHTGDLRTLKVLDRESKfvknNQYNISVVAVDAVG--RSCTG 561
Cdd:cd11304  11 PPGTVVLTVSATDPDSGENGEVTYSIVsGNEDGLFSIDPSTGEITTAKPLDREEQ----SSYTLTVTATDGGGppLSSTA 86

                        90
                ....*....|..
gi 4826702  562 TLVVHLDDYNDH 573
Cdd:cd11304  87 TVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
359-449 6.37e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 70.79  E-value: 6.37e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4826702    359 YVTEVEEN-RIDVEILRMKVQDQDLPntPHSKAVYKILQGNENGNFIISTDPntneGVLCVVKPLNYEVNRQVILQVGVI 437
Cdd:pfam00028   1 YSASVPENaPVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90
                  ....*....|..
gi 4826702    438 NEAQFSKAASSQ 449
Cdd:pfam00028  75 DSGGPPLSSTAT 86
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 494-575 3.22e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.53  E-value: 3.22e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4826702     494 KALDPEISSGEGLRYQKL-GDEDNWFEINQHTGDLRTLKVLDRESKfvknNQYNISVVAVDAVG--RSCTGTLVVHLDDY 570
Cdd:smart00112   1 SATDADSGENGKVTYSILsGNDDGLFSIDPETGEITTTKPLDREEQ----PEYTLTVEATDGGGppLSSTATVTITVLDV 76


                   ....*
gi 4826702     571 NDHAP 575
Cdd:smart00112  77 NDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 160-240 2.09e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 66.22  E-value: 2.09e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4826702     160 SDAAQNYTIFYSISGPGVDkepfNLFYIEKDTGDIFCTRSIDREKYEQFALYGYATTADGYAPEYPLPLIIKIEDDNDNA 239
Cdd:smart00112   5 ADSGENGKVTYSILSGNDD----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
gi 4826702     240 P 240
Cdd:smart00112  81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 138-238 1.86e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 63.87  E-value: 1.86e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4826702  138 PIPASLMENSlgPFPQHVQQIQ---SDAAQNYTIFYSISGPGvdkePFNLFYIEKDTGDIFCTRSIDREKYEQFALYGYA 214
Cdd:cd11304   1 SYEVSVPENA--PPGTVVLTVSatdPDSGENGEVTYSIVSGN----EDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTA 74

                        90       100
                ....*....|....*....|....
gi 4826702  215 TTADGYAPEYPLPLIIKIEDDNDN 238
Cdd:cd11304  75 TDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 358-449 6.10e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 62.72  E-value: 6.10e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4826702  358 SYVTEVEEN-RIDVEILRMKVQDQDLPntPHSKAVYKILQGNENGNFIIstDPNTneGVLCVVKPLNYEVNRQVILQVGV 436
Cdd:cd11304   1 SYEVSVPENaPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTA 74

                        90
                ....*....|...
gi 4826702  437 INEAQFSKAASSQ 449
Cdd:cd11304  75 TDGGGPPLSSTAT 87
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 139-238 9.77e-09

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 53.50  E-value: 9.77e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4826702  139 IPASLMENSLGPfpQHVQQIQSDAAQNYTIFYSISGPGVDKEPfNLFYIEKDTGDIFCTRSIDREKYEQFALYGYATTAD 218
Cdd:cd00031   2 PDGSAVEGRSRG--SFRVSIPTDLIASSGEIIKISAAGKEALP-SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLG 78

                        90       100
                ....*....|....*....|
gi 4826702  219 GYAPEYPLPLIIKIEDDNDN 238
Cdd:cd00031  79 ANVPQTSSVFSIEVYDENDN 98
Cadherin_pro pfam08758
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 31-111 7.15e-06

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 462590  Cd Length: 90  Bit Score: 45.01  E-value: 7.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4826702     31 QKVY-LRVPSHLQAETLVGKVNLEECL-KSASLIRSSDPAFRILEDGSIYTTHDLILSSERKSFSIFLSDGQRREQQEIK 108
Cdd:pfam08758   8 EEVYtFSVPRRLEEGQPLLNVKFNDCTgRKKTLYESSDPRFKVNTDGTVTAKRPVTLHGRQTSFLVHAWDSHGEKMASVK 87


                  ...
gi 4826702    109 VVL 111
Cdd:pfam08758  88 VTV 90
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 376-474 1.10e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 44.26  E-value: 1.10e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4826702     376 KVQDQDLPntPHSKAVYKILQGNENGNFIIstDPNTneGVLCVVKPLNYEVNRQVILQVGVINEAQFSKAASSQtptmct 455
Cdd:smart00112   1 SATDADSG--ENGKVTYSILSGNDDGLFSI--DPET--GEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTAT------ 68

                           90
                   ....*....|....*....
gi 4826702     456 ttVTVKIIDSDEgpecHPP 474
Cdd:smart00112  69 --VTITVLDVND----NAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 596-667 3.46e-04

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 40.03  E-value: 3.46e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4826702     596 VDPDGPENGPPFQFFLDNSASKNWNIEEKDGktaILRQRQNLDY---NYYSVPIQIKDRHG--LVATHMLTVRVCDC 667
Cdd:smart00112   3 TDADSGENGKVTYSILSGNDDGLFSIDPETG---EITTTKPLDReeqPEYTLTVEATDGGGppLSSTATVTITVLDV 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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