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Conserved domains on  [gi|27436981|ref|NP_004970|]
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A-type voltage-gated potassium channel KCND1 [Homo sapiens]

Protein Classification

potassium voltage-gated channel subfamily D member( domain architecture ID 13605726)

potassium voltage-gated channel subfamily D member (KCND) similar to Homo sapiens potassium voltage-gated channel subfamily D member 1 and 2

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
BTB_POZ super family cl38908
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
6-143 3.56e-105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


The actual alignment was detected with superfamily member cd18417:

Pssm-ID: 453885 [Multi-domain]  Cd Length: 138  Bit Score: 314.58  E-value: 3.56e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981   6 ATWLPFARAAAVGWLPLAQQPLPPAPGVKASRGDEVLVVNVSGRRFETWKNTLDRYPDTLLGSSEKEFFYDADSGEYFFD 85
Cdd:cd18417   1 ATWLPFARAAAVGWLPLAKKPMPKPPSDKKRRNDEILVVNVSGRRFQTWKNTLDRYPDTLLGSSEKEFFYNEDTQEYFFD 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 27436981  86 RDPDMFRHVLNFYRTGRLHCPRQECIQAFDEELAFYGLVPELVGDCCLEEYRDRKKEN 143
Cdd:cd18417  81 RDPEMFRHILNFYRTGRLHYPRHECIQAFDEELSFYGIIPEIIGDCCLEEYRDRKKEN 138
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
185-417 7.39e-52

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 179.00  E-value: 7.39e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981   185 ALVFYYVTGFFIAVSVIANVVETIPCRGsarrssreqpcgERFPQAFFCMDTACVLIFTGEYLLRLFAAPSRCRFLRSVM 264
Cdd:pfam00520   1 SRYFELFILLLILLNTIFLALETYFQPE------------EPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKRYFRSPW 68
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981   265 SLIDVVAILPYYIGLlVPKNDDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVM 344
Cdd:pfam00520  69 NILDFVVVLPSLISL-VLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIG 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981   345 FYAEKGT---------NKTNFTSIPAAFWYTIVTMTTLGYGDMVPSTIAGK-------IFGSICSLSGVLVIALPVPVIV 408
Cdd:pfam00520 148 YQLFGGKlktwenpdnGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKgefwayiYFVSFIILGGFLLLNLFIAVII 227

                  ....*....
gi 27436981   409 SNFSRIYHQ 417
Cdd:pfam00520 228 DNFQELTER 236
DUF3399 pfam11879
Domain of unknown function (DUF3399); This domain is functionally uncharacterized. This domain ...
470-550 1.82e-26

Domain of unknown function (DUF3399); This domain is functionally uncharacterized. This domain is found in eukaryotes. This presumed domain is about 100 amino acids in length. This domain is found associated with pfam02214, pfam00520.


:

Pssm-ID: 463381  Cd Length: 76  Bit Score: 102.84  E-value: 1.82e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981   470 NRSAFEQQHHHLLHCLEKTTCHEFTDELTFSEALGAVSPGGRTSRSTSVSSQPvgpgSLLSSCCPRRAKrRAIRLANSTA 549
Cdd:pfam11879   1 STSLFESQHHHLLHCLEKTTNHEFVDEQTYEQNCLEVSLQNRPSRSPSLSSQD----GLTSSCCSRRAK-RNTRLPNSSV 75

                  .
gi 27436981   550 S 550
Cdd:pfam11879  76 P 76
 
Name Accession Description Interval E-value
BTB_POZ_KCND1 cd18417
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
6-143 3.56e-105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 1 (KCND1); KCND1, also called voltage-gated potassium channel subunit Kv4.1, is a pore-forming subunit of voltage-gated rapidly inactivating A-type potassium channels. It may contribute to I (To) current in heart and I (Sa) current in neurons. Its properties are modulated by interactions with other alpha subunits and with regulatory subunits. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND1 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.


Pssm-ID: 349724 [Multi-domain]  Cd Length: 138  Bit Score: 314.58  E-value: 3.56e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981   6 ATWLPFARAAAVGWLPLAQQPLPPAPGVKASRGDEVLVVNVSGRRFETWKNTLDRYPDTLLGSSEKEFFYDADSGEYFFD 85
Cdd:cd18417   1 ATWLPFARAAAVGWLPLAKKPMPKPPSDKKRRNDEILVVNVSGRRFQTWKNTLDRYPDTLLGSSEKEFFYNEDTQEYFFD 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 27436981  86 RDPDMFRHVLNFYRTGRLHCPRQECIQAFDEELAFYGLVPELVGDCCLEEYRDRKKEN 143
Cdd:cd18417  81 RDPEMFRHILNFYRTGRLHYPRHECIQAFDEELSFYGIIPEIIGDCCLEEYRDRKKEN 138
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
185-417 7.39e-52

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 179.00  E-value: 7.39e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981   185 ALVFYYVTGFFIAVSVIANVVETIPCRGsarrssreqpcgERFPQAFFCMDTACVLIFTGEYLLRLFAAPSRCRFLRSVM 264
Cdd:pfam00520   1 SRYFELFILLLILLNTIFLALETYFQPE------------EPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKRYFRSPW 68
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981   265 SLIDVVAILPYYIGLlVPKNDDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVM 344
Cdd:pfam00520  69 NILDFVVVLPSLISL-VLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIG 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981   345 FYAEKGT---------NKTNFTSIPAAFWYTIVTMTTLGYGDMVPSTIAGK-------IFGSICSLSGVLVIALPVPVIV 408
Cdd:pfam00520 148 YQLFGGKlktwenpdnGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKgefwayiYFVSFIILGGFLLLNLFIAVII 227

                  ....*....
gi 27436981   409 SNFSRIYHQ 417
Cdd:pfam00520 228 DNFQELTER 236
BTB_2 pfam02214
BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific ...
42-131 1.00e-39

BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.


Pssm-ID: 426665 [Multi-domain]  Cd Length: 93  Bit Score: 140.42  E-value: 1.00e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981    42 LVVNVSGRRFETWKNTLDRYPDTLLGSSEKE--FFYDADSGEYFFDRDPDMFRHVLNFYRT-GRLHCPRQECIQAFDEEL 118
Cdd:pfam02214   1 VKLNVGGTRFETLKSTLTRFPDTRLGRLLELecDDYDDDTNEYFFDRSPKHFETILNFYRTgGKLHRPEEVCLDEFLEEA 80
                          90
                  ....*....|...
gi 27436981   119 AFYGLVPELVGDC 131
Cdd:pfam02214  81 EFYGLDELALELC 93
DUF3399 pfam11879
Domain of unknown function (DUF3399); This domain is functionally uncharacterized. This domain ...
470-550 1.82e-26

Domain of unknown function (DUF3399); This domain is functionally uncharacterized. This domain is found in eukaryotes. This presumed domain is about 100 amino acids in length. This domain is found associated with pfam02214, pfam00520.


Pssm-ID: 463381  Cd Length: 76  Bit Score: 102.84  E-value: 1.82e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981   470 NRSAFEQQHHHLLHCLEKTTCHEFTDELTFSEALGAVSPGGRTSRSTSVSSQPvgpgSLLSSCCPRRAKrRAIRLANSTA 549
Cdd:pfam11879   1 STSLFESQHHHLLHCLEKTTNHEFVDEQTYEQNCLEVSLQNRPSRSPSLSSQD----GLTSSCCSRRAK-RNTRLPNSSV 75

                  .
gi 27436981   550 S 550
Cdd:pfam11879  76 P 76
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
42-132 7.91e-21

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 87.36  E-value: 7.91e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981     42 LVVNVSGRRFETWKNTLDRYPDTLLGSSEKEFFYDADSGEYFFDRDPDMFRHVLNFYRTGRLHCPrQECIQAFDEELAFY 121
Cdd:smart00225   2 VTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLP-EENVEELLELADYL 80
                           90
                   ....*....|.
gi 27436981    122 gLVPELVGDCC 132
Cdd:smart00225  81 -QIPGLVELCE 90
PRK10537 PRK10537
voltage-gated potassium channel protein;
302-414 7.37e-10

voltage-gated potassium channel protein;


Pssm-ID: 236711 [Multi-domain]  Cd Length: 393  Bit Score: 61.19  E-value: 7.37e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981  302 IFKFSRHSQGLRILGYTLKSCAselgFLLF--------SLT----MAIIIFATVMFYAEKGT------NKTNFTSIPAAF 363
Cdd:PRK10537  98 AITLHFYPWLKFLIGYCIVLLV----ALLIyrrdfdrsSLAagtlFAVISITSLLFYSTFGAlylgdgFSPPIESLSTAF 173
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 27436981  364 WYTIVTMTTLGYGDMVPSTIAGKIFGSICSLSGVLVIA-----LPVPVIVSNFSRI 414
Cdd:PRK10537 174 YFSIVTMSTVGYGDIVPVSESARLFTISVIILGITVFAtsisaIFGPVIRGNLKRL 229
 
Name Accession Description Interval E-value
BTB_POZ_KCND1 cd18417
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
6-143 3.56e-105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 1 (KCND1); KCND1, also called voltage-gated potassium channel subunit Kv4.1, is a pore-forming subunit of voltage-gated rapidly inactivating A-type potassium channels. It may contribute to I (To) current in heart and I (Sa) current in neurons. Its properties are modulated by interactions with other alpha subunits and with regulatory subunits. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND1 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.


Pssm-ID: 349724 [Multi-domain]  Cd Length: 138  Bit Score: 314.58  E-value: 3.56e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981   6 ATWLPFARAAAVGWLPLAQQPLPPAPGVKASRGDEVLVVNVSGRRFETWKNTLDRYPDTLLGSSEKEFFYDADSGEYFFD 85
Cdd:cd18417   1 ATWLPFARAAAVGWLPLAKKPMPKPPSDKKRRNDEILVVNVSGRRFQTWKNTLDRYPDTLLGSSEKEFFYNEDTQEYFFD 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 27436981  86 RDPDMFRHVLNFYRTGRLHCPRQECIQAFDEELAFYGLVPELVGDCCLEEYRDRKKEN 143
Cdd:cd18417  81 RDPEMFRHILNFYRTGRLHYPRHECIQAFDEELSFYGIIPEIIGDCCLEEYRDRKKEN 138
BTB_POZ_KCND3 cd18419
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
6-143 1.07e-83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 3 (KCND3); KCND3, also called voltage-gated potassium channel subunit Kv4.3, is a pore-forming subunit of voltage-gated rapidly inactivating A-type potassium channels. Mutations in KCND3 cause spinocerebellar ataxia. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND3 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.


Pssm-ID: 349726 [Multi-domain]  Cd Length: 138  Bit Score: 259.13  E-value: 1.07e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981   6 ATWLPFARAAAVGWLPLAQQPLPPAPGVKASRGDEVLVVNVSGRRFETWKNTLDRYPDTLLGSSEKEFFYDADSGEYFFD 85
Cdd:cd18419   1 AAWLPFARAAAIGWMPVANCPMPLAPADKNKRQDELIVLNVSGRRFQTWRTTLERYPDTLLGSTEKEFFFNEDTKEYFFD 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 27436981  86 RDPDMFRHVLNFYRTGRLHCPRQECIQAFDEELAFYGLVPELVGDCCLEEYRDRKKEN 143
Cdd:cd18419  81 RDPEVFRCVLNFYRTGKLHYPRYECISAYDEELAFYGILPEIIGDCCYEEYKDRKREN 138
BTB_POZ_Shal-like cd18420
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
8-143 6.55e-81

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster potassium voltage-gated channel protein Shal and similar proteins; Drosophila melanogaster Shal, also called Shaker cognate l or Shal2, is a transient potassium current (I(A)) channel, which is required for maintaining excitability during repetitive firing and normal locomotion in Drosophila. It may play a role in the nervous system and in the regulation of beating frequency in pacemaker cells. Shal mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shal is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349727 [Multi-domain]  Cd Length: 139  Bit Score: 252.08  E-value: 6.55e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981   8 WLPFARAAAVGWLPLAQQPLPPAPGVKASR--GDEVLVVNVSGRRFETWKNTLDRYPDTLLGSSEKEFFYDADSGEYFFD 85
Cdd:cd18420   2 WLPFARAAAIGWVPIANNPLPPPPVDQERRrtDDEKLIINVSGRRFETWRNTLEKYPDTLLGSNEREFFYDEETKEYFFD 81
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 27436981  86 RDPDMFRHVLNFYRTGRLHCPRQECIQAFDEELAFYGLVPELVGDCCLEEYRDRKKEN 143
Cdd:cd18420  82 RDPDIFRHILNYYRTGKLHYPKHECLTAYDEELAFFGIMPDIIGDCCYEDYRDRKREN 139
BTB_POZ_Kv4_KCND cd18380
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
42-142 3.07e-73

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCND/Kv4 subfamily of Shal-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv4, also known as subfamily D, contains three alpha subunit members, Kv4.1 (KCND1), Kv4.2 (KCND2), and Kv4.3 (KCND3), which are orthologs of the Shal gene in Drosophila. They are A-type potassium channels that mediate the native, fast inactivating (A-type) K+ current (IA) described both in the nervous system (A currents) and the heart (transient outward current). Kv4/KCND subfamily alpha subunits form functional homo- or hetero-tetrameric channels through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. They are modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.


Pssm-ID: 349689 [Multi-domain]  Cd Length: 102  Bit Score: 230.33  E-value: 3.07e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981  42 LVVNVSGRRFETWKNTLDRYPDTLLGSSEKEFFYDADSGEYFFDRDPDMFRHVLNFYRTGRLHCPRQECIQAFDEELAFY 121
Cdd:cd18380   2 IVINVSGRRFETWKNTLEKYPDTLLGSTEKEFFYDDDTKEYFFDRDPEIFRHILNFYRTGKLHYPRHECISAYDDELAFF 81
                        90       100
                ....*....|....*....|.
gi 27436981 122 GLVPELVGDCCLEEYRDRKKE 142
Cdd:cd18380  82 GILPEIIGDCCYEDYRDRKRE 102
BTB_POZ_KCND2 cd18418
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
41-143 3.18e-65

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 2 (KCND2); KCND2, also called voltage-gated potassium channel subunit Kv4.2, is a major pore-forming subunit in somatodendritic subthreshold A-type potassium current I(SA) channels. It mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND2 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.


Pssm-ID: 349725 [Multi-domain]  Cd Length: 103  Bit Score: 209.43  E-value: 3.18e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981  41 VLVVNVSGRRFETWKNTLDRYPDTLLGSSEKEFFYDADSGEYFFDRDPDMFRHVLNFYRTGRLHCPRQECIQAFDEELAF 120
Cdd:cd18418   1 LIVLNVSGTRFQTWRNTLERYPDTLLGSSERDFFYHEETQEYFFDRDPDIFRHILNFYRTGKLHYPRHECISAYDEELAF 80
                        90       100
                ....*....|....*....|...
gi 27436981 121 YGLVPELVGDCCLEEYRDRKKEN 143
Cdd:cd18418  81 FGIIPEIIGDCCYEEYKDRRREN 103
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
185-417 7.39e-52

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 179.00  E-value: 7.39e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981   185 ALVFYYVTGFFIAVSVIANVVETIPCRGsarrssreqpcgERFPQAFFCMDTACVLIFTGEYLLRLFAAPSRCRFLRSVM 264
Cdd:pfam00520   1 SRYFELFILLLILLNTIFLALETYFQPE------------EPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKRYFRSPW 68
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981   265 SLIDVVAILPYYIGLlVPKNDDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVM 344
Cdd:pfam00520  69 NILDFVVVLPSLISL-VLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIG 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981   345 FYAEKGT---------NKTNFTSIPAAFWYTIVTMTTLGYGDMVPSTIAGK-------IFGSICSLSGVLVIALPVPVIV 408
Cdd:pfam00520 148 YQLFGGKlktwenpdnGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKgefwayiYFVSFIILGGFLLLNLFIAVII 227

                  ....*....
gi 27436981   409 SNFSRIYHQ 417
Cdd:pfam00520 228 DNFQELTER 236
BTB_2 pfam02214
BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific ...
42-131 1.00e-39

BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.


Pssm-ID: 426665 [Multi-domain]  Cd Length: 93  Bit Score: 140.42  E-value: 1.00e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981    42 LVVNVSGRRFETWKNTLDRYPDTLLGSSEKE--FFYDADSGEYFFDRDPDMFRHVLNFYRT-GRLHCPRQECIQAFDEEL 118
Cdd:pfam02214   1 VKLNVGGTRFETLKSTLTRFPDTRLGRLLELecDDYDDDTNEYFFDRSPKHFETILNFYRTgGKLHRPEEVCLDEFLEEA 80
                          90
                  ....*....|...
gi 27436981   119 AFYGLVPELVGDC 131
Cdd:pfam02214  81 EFYGLDELALELC 93
BTB_POZ_Kv cd18317
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
42-122 3.60e-31

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. This family includes several groups of alpha subunits such as KCNA/Kv1 family of Shaker-type Kv channels, KCNB/Kv2 family of Shab-type Kv channels, KCNC/Kv3 family of Shaw-type Kv channels, KCND/Kv4 family of Shal-type Kv channels, KCNF/Kv5 subfamily of Kv channels, KCNG/Kv6 subfamily of Kv channels, KCNV/Kv8 subfamily of Kv channels, and KCNS/Kv9 subfamily of Kv channels. Kv alpha subunits form functional homo- or hetero-tetrameric channels (typically with other alpha subunits from the same subfamily) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. KCNQ/Kv7 channels are not included in this family, since they do not contain a BTB/POZ domain.


Pssm-ID: 349626  Cd Length: 82  Bit Score: 116.17  E-value: 3.60e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981  42 LVVNVSGRRFETWKNTLDRYPDTLLGS-SEKEFFYDADSGEYFFDRDPDMFRHVLNFYRTGRLHCPRQECIQAFDEELAF 120
Cdd:cd18317   1 VVLNVGGTRFELSRSTLLRFPDTRLGKlAKESHAYDESTNEYFFDRNPEVFEAILDYYRTGELHLPSNVCPASFKEELEF 80

                ..
gi 27436981 121 YG 122
Cdd:cd18317  81 WG 82
BTB_POZ_Kv_KCTD cd18187
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
42-121 3.78e-31

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels and potassium channel tetramerization domain-containing (KCTD) proteins; This family includes two protein groups: voltage-gated potassium (Kv) channels and potassium channel tetramerization domain-containing (KCTD) proteins. Kv channels are membrane proteins with fundamental physiological roles. They are responsible for a variety of electrical phenomena, such as the repolarization of the action potential, spike frequency adaptation, synaptic repolarization, and smooth muscle contraction. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels, and others. All family members contain the BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.


Pssm-ID: 349498  Cd Length: 83  Bit Score: 116.42  E-value: 3.78e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981  42 LVVNVSGRRFETWKNTLDRYPDTLLGSSEK---EFFYDADSGEYFFDRDPDMFRHVLNFYRTGRLHCPRQECIQAFDEEL 118
Cdd:cd18187   1 VVLNVSGTRFVTNRQTLTRHPDTLLGRMFKpgrEFTFPNETGEYFIDRDPTVFRTILNYYRTGKLNCPDGISIPDLREEC 80

                ...
gi 27436981 119 AFY 121
Cdd:cd18187  81 DFY 83
BTB_POZ_Kv3_KCNC cd18379
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
42-141 6.69e-30

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNC/Kv3 subfamily of Shaw-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv3, also known as subfamily C, contains four alpha subunit members, Kv3.1 (KCNC1), Kv3.2 (KCNC2), Kv3.3 (KCNC3), and Kv3.4 (KCNC4), which are orthologs of the Shaw gene in Drosophila. Unlike other Kv subfamilies, Kv3 channels typically open only at positive potentials and both, activation and deactivation, in response to changes in voltage are very rapid. They are uniquely associated with the ability of certain neurons to fire action potentials and to release neurotransmitter at high rates of up to 1,000 Hz. Kv3/KCNC subfamily alpha subunits form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349688 [Multi-domain]  Cd Length: 109  Bit Score: 113.64  E-value: 6.69e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981  42 LVVNVSGRRFETWKNTLDRYPDTLLGS----SEKEFFYDADSGEYFFDRDPDMFRHVLNFYRTGRLHCPRQECIQAFDEE 117
Cdd:cd18379   1 IVINVGGVRHETYKSTLRNLPDTRLAWltetEASAFDYDPVTGEFFFDRHPGVFAQILNYYRTGKLHCPADVCGPLFEEE 80
                        90       100
                ....*....|....*....|....
gi 27436981 118 LAFYGLVPELVGDCCLEEYRDRKK 141
Cdd:cd18379  81 LAFWGIDETQIEPCCWMTYRQHRD 104
BTB_KCNC1_3 cd18414
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
40-144 6.40e-28

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC1 and KCNC3; KCNC1 (also called NGK2, voltage-gated potassium channel subunit Kv3.1, or voltage-gated potassium channel subunit Kv4) and KCNC3 (also called KSHIIID or voltage-gated potassium channel subunit Kv3.3) play important roles in the rapid repolarization of fast-firing brain neurons. Assuming opened or closed conformations in response to the voltage difference across the membrane, the proteins form tetrameric potassium-selective channels through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNC1 and KCNC3 are alpha subunit that form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349721 [Multi-domain]  Cd Length: 117  Bit Score: 108.50  E-value: 6.40e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981  40 EVLVVNVSGRRFETWKNTLDRYPDT-LLGSSEKE----FFYDADSGEYFFDRDPDMFRHVLNFYRTGRLHCPRQECIQAF 114
Cdd:cd18414   3 DRIVINVGGTRHETYRSTLRTLPGTrLAWLAEPDahsnFDYDPRADEFFFDRHPGVFAHILNYYRTGKLHCPADVCGPLY 82
                        90       100       110
                ....*....|....*....|....*....|.
gi 27436981 115 DEELAFYGLVPELVGDCCLEEYRD-RKKENA 144
Cdd:cd18414  83 EEELAFWGIDETDVEPCCWMTYRQhRDAEEA 113
DUF3399 pfam11879
Domain of unknown function (DUF3399); This domain is functionally uncharacterized. This domain ...
470-550 1.82e-26

Domain of unknown function (DUF3399); This domain is functionally uncharacterized. This domain is found in eukaryotes. This presumed domain is about 100 amino acids in length. This domain is found associated with pfam02214, pfam00520.


Pssm-ID: 463381  Cd Length: 76  Bit Score: 102.84  E-value: 1.82e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981   470 NRSAFEQQHHHLLHCLEKTTCHEFTDELTFSEALGAVSPGGRTSRSTSVSSQPvgpgSLLSSCCPRRAKrRAIRLANSTA 549
Cdd:pfam11879   1 STSLFESQHHHLLHCLEKTTNHEFVDEQTYEQNCLEVSLQNRPSRSPSLSSQD----GLTSSCCSRRAK-RNTRLPNSSV 75

                  .
gi 27436981   550 S 550
Cdd:pfam11879  76 P 76
BTB_Shaw-like cd18416
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
39-136 3.42e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel protein Shaw; Shaw, also called Shaw2, is a voltage-gated potassium channel in Drosophila. It mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shaw is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349723 [Multi-domain]  Cd Length: 112  Bit Score: 94.64  E-value: 3.42e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981  39 DEVLVVNVSGRRFETWKNTLDRYPDTLLGS-SEKEFFYDADSGEYFFDRDPDMFRHVLNFYRTGRLHCPRQECIQAFDEE 117
Cdd:cd18416   1 ENRVVLNVGGIRHETYKATLKKIPATRLSRlTEALANYDPVLNEYFFDRHPGVFAQILNYYRTGKLHYPTDVCGPLFEEE 80
                        90
                ....*....|....*....
gi 27436981 118 LAFYGLVPELVGDCCLEEY 136
Cdd:cd18416  81 LEFWGLDANQVEPCCWMTY 99
BTB_POZ_Kv2_KCNB cd18378
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
44-136 8.77e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNB/Kv2 subfamily of Shab-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv3, also known as subfamily C, contains two alpha subunit members, Kv2.1 (KCNB1) and Kv2.2 (KCNB2), which are orthologs of the Shab gene in Drosophila. They are delayed-rectifier potassium currents in various neurons, although their physiological roles often remain elusive. Kv2/KCNB subfamily alpha subunits form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349687 [Multi-domain]  Cd Length: 109  Bit Score: 93.61  E-value: 8.77e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981  44 VNVSGRRFETWKNTLDRYPDTLLG--------SSEKEFF--YDADSGEYFFDRDPDMFRHVLNFYRTGRLHCPRQECIQA 113
Cdd:cd18378   6 LNVGGVRHEVLWRTLDRLPRTRLGrlrecnthESLLELCddYDLEDNEYFFDRHPGAFTSILNFYRTGKLHMPEEMCVLS 85
                        90       100
                ....*....|....*....|...
gi 27436981 114 FDEELAFYGLVPELVGDCCLEEY 136
Cdd:cd18378  86 FSQELEYWGIDEIYLESCCQHRY 108
BTB_KCNC2_4 cd18415
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
39-144 1.11e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4; KCNC2, also called Shaw-like potassium channel or voltage-gated potassium channel Kv3.2, is a delayed rectifier voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. It contributes to the regulation of the fast action potential repolarization and in sustained high-frequency firing in neurons of the central nervous system. KCNC4, also called KSHIIIC or voltage-gated potassium channel subunit Kv3.4, is a novel high-voltage-activating, tetraethylammonium (TEA)-sensitive, type-A potassium channel that mediates the voltage-dependent potassium ion permeability of excitable membranes. It plays a pivotal role in oxidative stress-related neural cell damage as an oxidation-sensitive channel. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNC2 and KCNC4 are alpha subunit that form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349722 [Multi-domain]  Cd Length: 124  Bit Score: 90.99  E-value: 1.11e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981  39 DEVLVVNVSGRRFETWKNTLDRYPDT---LLGSSEKE-------------FFYDADSGEYFFDRDPDMFRHVLNFYRTGR 102
Cdd:cd18415   1 NERIILNVGGTRHETYRSTLKTLPGTrlaLLASSDPQgdcltqcsqvggsDGSPGGGNEFFFDRHPGVFAYVLNYYRTGK 80
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 27436981 103 LHCPRQECIQAFDEELAFYGLVPELVGDCCLEEYRD-RKKENA 144
Cdd:cd18415  81 LHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQhRDAEEA 123
BTB_POZ_KCNV1 cd18424
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
42-140 5.66e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily V member 1 (KCNV1); KCNV1, also called neuronal potassium channel alpha subunit HNKA or voltage-gated potassium channel subunit Kv8.1, is a new neuronal voltage-gated potassium channel alpha subunit with specific inhibitory properties towards Shab and Shaw channels. It modulates KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2) channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. It can also down-regulate the channel activity of KCNB1, KCNB2, KCNC4 (also known as Kv3.4) and KCND1 (also known as Kv4.1), possibly by trapping them in intracellular membranes. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNV1 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349731  Cd Length: 109  Bit Score: 88.33  E-value: 5.66e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981  42 LVVNVSGRRFETWKNTLDRYPDTLLG---SSEKEFFY----DAD--SGEYFFDRDPDMFRHVLNFYRTGRLHCPRQECIQ 112
Cdd:cd18424   1 FTINVGGSRFVLSQQVLSSHPETRLGklaVSVRDSVLelcdDANfvDNEYFFDRSSQAFKYIMNYYKTGHLHVMEELCAI 80
                        90       100
                ....*....|....*....|....*...
gi 27436981 113 AFDEELAFYGLVPELVGDCCLEEYRDRK 140
Cdd:cd18424  81 SFLQEIEYWGIDELSIDSCCRERYYRRK 108
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
42-132 7.91e-21

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 87.36  E-value: 7.91e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981     42 LVVNVSGRRFETWKNTLDRYPDTLLGSSEKEFFYDADSGEYFFDRDPDMFRHVLNFYRTGRLHCPrQECIQAFDEELAFY 121
Cdd:smart00225   2 VTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLP-EENVEELLELADYL 80
                           90
                   ....*....|.
gi 27436981    122 gLVPELVGDCC 132
Cdd:smart00225  81 -QIPGLVELCE 90
BTB_POZ_Kv1_KCNA cd18377
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
40-121 5.84e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNA/Kv1 subfamily of Shaker-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv1, also known as subfamily A, contains eight alpha subunit members, Kv1.1 (KCNA1), Kv1.2 (KCNA2), Kv1.3 (KCNA3), Kv1.4 (KCNA4), Kv1.5 (KCNA5), Kv1.6 (KCNA6), Kv1.7 (KCNA7), and Kv1.8 (KCNA10), which are orthologs of the Shaker gene in Drosophila. They are delayed rectifiers except for Kv1.4 (KCNA4), which is an A-type potassium channel. Delayed rectifiers are slow opening and closing voltage-gated potassium channels. Because of their delayed activation kinetics, they play an important role in controlling action potential duration. A-type channels are fast/rapidly inactivating potassium channels. Kv1/KCNA subfamily alpha subunits form functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349686  Cd Length: 85  Bit Score: 84.65  E-value: 5.84e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981  40 EVLVVNVSGRRFETWKNTLDRYPDTLLGSSEKEF-FYDADSGEYFFDRDPDMFRHVLNFYRT-GRLHCPRQECIQAFDEE 117
Cdd:cd18377   1 ERVVINVSGLRFETQLKTLAQFPNTLLGDPNKRMrFFDPLRNEYFFDRNRPSFDAILYYYQSgGRLRRPVNVPLDIFLEE 80

                ....
gi 27436981 118 LAFY 121
Cdd:cd18377  81 IRFY 84
BTB_POZ_Shaker-like cd18410
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
40-138 2.69e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster potassium voltage-gated channel protein Shaker and similar proteins; Shaker, also termed protein minisleep, represents a family of putative potassium channel proteins in the nervous system of Drosophila. It is a voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Shaker plays a role in the regulation of sleep need or efficiency. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shaker is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349717  Cd Length: 100  Bit Score: 80.36  E-value: 2.69e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981  40 EVLVVNVSGRRFETWKNTLDRYPDTLLGSSEKEF-FYDADSGEYFFDRDPDMFRHVLNFYRT-GRLHCPRQECIQAFDEE 117
Cdd:cd18410   1 ERVVINVSGLRFETQLKTLNQFPDTLLGDPQRRNrYYDPLRNEYFFDRNRPSFDAILYYYQSgGRLRRPVNVPLDVFSEE 80
                        90       100
                ....*....|....*....|.
gi 27436981 118 LAFYGLvpelvGDCCLEEYRD 138
Cdd:cd18410  81 IKFYEL-----GENAFEKYRE 96
BTB_POZ_KCNA7 cd18408
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
40-129 6.07e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A member 7 (KCNA7); KCNA7, also called voltage-gated potassium channel subunit Kv1.7, mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNA7 plays an important role in the repolarization of cell membranes. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNA7 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349715  Cd Length: 115  Bit Score: 79.97  E-value: 6.07e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981  40 EVLVVNVSGRRFETWKNTLDRYPDTLLGS-SEKEFFYDADSGEYFFDRDPDMFRHVLNFYRT-GRLHCPRQECIQAFDEE 117
Cdd:cd18408   6 ERVVLNVAGLRFETRARTLGRFPDTLLGDpARRGRFYDDRRREYFFDRHRPSFDAVLYYYQSgGRLRRPAHVPLDVFLEE 85
                        90
                ....*....|..
gi 27436981 118 LAFYGLVPELVG 129
Cdd:cd18408  86 VAFYGLGAAALA 97
BTB_POZ_KCNA2_KCNA3 cd18403
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
40-138 1.16e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A members 2 (KCNA2) and 3 (KCNA3); KCNA2 is also called NGK1, voltage-gated K(+) channel HuKIV, voltage-gated potassium channel HBK5, or voltage-gated potassium channel subunit Kv1.2. KCNA3 is also called HGK5, HLK3, HPCN3, voltage-gated K(+) channel HuKIII, or voltage-gated potassium channel subunit Kv1.3. KCNA2 and KCNA3 mediate transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNA2 primarily functions in the brain and the central nervous system, but also in the cardiovascular system. It prevents aberrant action potential firing and regulates neuronal output. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNA2 and KCNA3 are alpha subunits that form functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349711  Cd Length: 99  Bit Score: 78.47  E-value: 1.16e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981  40 EVLVVNVSGRRFETWKNTLDRYPDTLLGSSEKEF-FYDADSGEYFFDRDPDMFRHVLNFYRT-GRLHCPRQECIQAFDEE 117
Cdd:cd18403   1 ERVVINISGLRFETQLKTLAQFPETLLGDPKKRMrYFDPLRNEYFFDRNRPSFDAILYYYQSgGRLRRPVNVPLDIFSEE 80
                        90       100
                ....*....|....*....|.
gi 27436981 118 LAFYGLvpelvGDCCLEEYRD 138
Cdd:cd18403  81 IRFYEL-----GEEAMEMFRE 96
BTB_POZ_KCTD-like cd18316
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
42-121 1.32e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins; The potassium channel tetramerization domain (KCTD) family proteins contain the BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. Some others show Cullin-independent functions including binding and regulation of GABA (gamma-aminobutyric acid) receptors (KCTD8, KCTD12 and KCTD16) and inhibition of AP-2 function (KCTD15). KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349625  Cd Length: 83  Bit Score: 77.98  E-value: 1.32e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981  42 LVVNVSGRRFETWKNTLDRYPDTLLGS--SEKEFFYDADSGEYFFDRDPDMFRHVLNFYRTGRLHCPRQEC-IQAFDEEL 118
Cdd:cd18316   1 VKLNVGGTLFTTSRSTLLKDPDSLLAAlfSGRWPLPRDEDGSIFIDRDPELFRHILNFLRTGKLPLPSDFVeLEELLAEA 80

                ...
gi 27436981 119 AFY 121
Cdd:cd18316  81 EFY 83
BTB_POZ_Shab-like cd18413
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
42-136 1.86e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster potassium voltage-gated channel protein Shab and similar proteins; Shab is a slow delayed rectifier voltage-gated potassium channel in Drosophila. It mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shab is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349720 [Multi-domain]  Cd Length: 109  Bit Score: 78.38  E-value: 1.86e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981  42 LVVNVSGRRFETWKNTLDRYPDTLLG----SSEKEFF------YDADSGEYFFDRDPDMFRHVLNFYRTGRLHCPRQECI 111
Cdd:cd18413   4 VVINVGGVKHEVLWRTLDRMPHTRLGklrdSNTHEAIvelcddYSLADNEYFFDRHPRSFASILNFYRTGKLHLVEEMCV 83
                        90       100
                ....*....|....*....|....*
gi 27436981 112 QAFDEELAFYGLVPELVGDCCLEEY 136
Cdd:cd18413  84 LAFSDDLEYWGVDELYLESCCQHKY 108
BTB_POZ_KCNS2 cd18427
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
44-137 4.50e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 2 (KCNS2); KCNS2, also called delayed-rectifier K(+) channel alpha subunit 2 or voltage-gated potassium channel subunit Kv9.2, is a modulatory alpha subunit of voltage-gated potassium channel that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNS2 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349734  Cd Length: 107  Bit Score: 77.20  E-value: 4.50e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981  44 VNVSGRRFETWKNTLDRYPDT----LLGSSEKEFF------YDADSGEYFFDRDPDMFRHVLNFYRTGRLHCPRQECIQA 113
Cdd:cd18427   4 INVGGFKKRLRSHTLLRFPETrlgrLLSCRSKESIlelcddYDDTKNEFYFDRNPELFPYVLHFYNTGKLHVMGELCVFS 83
                        90       100
                ....*....|....*....|....
gi 27436981 114 FDEELAFYGLVPELVGDCCLEEYR 137
Cdd:cd18427  84 FSQEIEYWGINEFFIDSCCSYSYH 107
BTB_POZ_KCNS3 cd18428
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
40-137 5.94e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 3 (KCNS3); KCNS3, also called delayed-rectifier K(+) channel alpha subunit 3 or voltage-gated potassium channel subunit Kv9.3, is an alpha subunit of voltage-gated potassium channel linked to tissue oxygenation responses. It can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNS3 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349735  Cd Length: 108  Bit Score: 76.80  E-value: 5.94e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981  40 EVLVVNVSGRRFETWKNTLDRYPDTLLG-----SSEKEFF-----YDADSGEYFFDRDPDMFRHVLNFYRTGRLHCPRQE 109
Cdd:cd18428   1 ELINLNVGGFKQSVDQSTLLRFPHTRLGkllncHSEEAILelcddYSVADKEYYFDRNPSLFRYVLNFYYTGKLHVMEEL 80
                        90       100
                ....*....|....*....|....*...
gi 27436981 110 CIQAFDEELAFYGLVPELVGDCCLEEYR 137
Cdd:cd18428  81 CVFSFCQEIEYWGINELFIDSCCSNRYQ 108
BTB_POZ_Kv6_KCNG cd18382
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
42-139 6.66e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNG/Kv6 subfamily of potassium voltage-gated channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv6, also known as subfamily G, includes KCNG1 (Kv6.1), KCNG2 (Kv6.2 or KCNF2), KCNG3 (Kv6.3) and KCNG4 (Kv6.4), which are regulatory alpha subunits and do not form functional channels on their own. KCNG1 can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. KCNG2, also called cardiac potassium channel subunit, can form functional heterodimeric channels with KCNB1, and further modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. KCNG3, also called voltage-gated potassium channel subunit Kv10.1, is an electrically silent modulatory subunit that can form functional heterotetrameric channels with KCNB1, and further promotes a reduction in the rate of activation and inactivation of the delayed rectifier voltage-gated potassium channel KCNB1. KCNG4 is a silent voltage-gated potassium (KvS) channel subunit that can form functional heterotetrameric channels with KCNB1, and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1.


Pssm-ID: 349691 [Multi-domain]  Cd Length: 109  Bit Score: 76.70  E-value: 6.66e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981  42 LVVNVSGRRFETWKNTLDRYPDTLLG-----SSEKEFF-----YDADSGEYFFDRDPDMFRHVLNFYRTGRLHCPRQECI 111
Cdd:cd18382   1 VIINVGGARYSLPWSTLDRFPLTRLSrlkacRSEDDILrvcddYDVERNEFFFDRSPEAFGVILLFLRAGKLRLLREMCA 80
                        90       100
                ....*....|....*....|....*...
gi 27436981 112 QAFDEELAFYGLVPELVGDCCLEEYRDR 139
Cdd:cd18382  81 LSFQEELAYWGIEEAHLERCCKRRLLRR 108
BTB_POZ_KCNA6 cd18407
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
40-182 1.12e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A member 6 (KCNA6); KCNA6, also called voltage-gated potassium channel HBK2 or voltage-gated potassium channel subunit Kv1.6, mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNA6 is distributed primarily in neurons of central and peripheral nervous systems. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNA6 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349714 [Multi-domain]  Cd Length: 127  Bit Score: 76.57  E-value: 1.12e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981  40 EVLVVNVSGRRFETWKNTLDRYPDTLLGS-SEKEFFYDADSGEYFFDRDPDMFRHVLNFYRT-GRLHCPRQECIQAFDEE 117
Cdd:cd18407   1 ERLVINISGLRFETQLRTLSIFPDTLLGDpSRRVRYFDPLRNEYFFDRNRPSFDAILYYYQSgGRLRRPVHVPLDIFLEE 80
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27436981 118 LAFYGLvpelvGDCCLEEYRdrkkenaerlaEDEEAEQAGDGPaLPAGSSLRQrLWRAFENPHTS 182
Cdd:cd18407  81 IRFYQL-----GQEAIETFR-----------EDEGFIPEEEKP-LPSHHFQRQ-VWLLFEYPESS 127
BTB_POZ_KCNS1 cd18426
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
44-136 1.71e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 1 (KCNS1); KCNS1, also called delayed-rectifier K(+) channel alpha subunit 1 or voltage-gated potassium channel subunit Kv9.1, is a modulatory alpha subunit of voltage-gated potassium channel that mediates neuropathic pain following nerve injury. It can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNS1 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349733 [Multi-domain]  Cd Length: 106  Bit Score: 75.31  E-value: 1.71e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981  44 VNVSGRRFETWKNTLDRYPDTLLG-----SSEKEFF-----YDADSGEYFFDRDPDMFRHVLNFYRTGRLHCPRQECIQA 113
Cdd:cd18426   3 INVGGLKRRLSSSTLSKFPDTRLGrllscDSEESILqicddYDVSAKEFYFDRNPGLFPYVLHFYQTGKLHIMEELCVFS 82
                        90       100
                ....*....|....*....|...
gi 27436981 114 FDEELAFYGLVPELVGDCCLEEY 136
Cdd:cd18426  83 FSQEIEYWGINEFFLDSCCSYRY 105
BTB_POZ_Kv5_KCNF1 cd18381
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
41-138 2.81e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNF/Kv5 subfamily of potassium voltage-gated channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv5, also known as subfamily F, only contains KCNF1 (also known as Kv5.1 or kH1), which functions as a regulatory alpha-subunit of voltage-gated potassium channel that when coassembled with Kv2.1 can modulate gating in a physiologically relevant manner. It forms hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349690  Cd Length: 116  Bit Score: 75.18  E-value: 2.81e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981  41 VLVVNVSGRRFETWKNTLDRYPDTLL-------GSSEKEFF-----YDADSGEYFFDRDPDMFRHVLNFYRTGRLHCPRQ 108
Cdd:cd18381   2 EIVVNVGGVRQVLYGDVLNRYPETRLaellnclSGGYDAIFslcddYDPGKREFYFDRDPDAFKCIIEVYYYGEIHMKKG 81
                        90       100       110
                ....*....|....*....|....*....|...
gi 27436981 109 ECIQAFDEELAFYGLVPELVGDCC---LEEYRD 138
Cdd:cd18381  82 ICPICFKNEMDFWRVDLDFLDECCkchLSEKRE 114
BTB_POZ_KCNB2 cd18412
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
27-140 2.85e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily B member 2 (KCNB2); KCNB2, also called voltage-gated potassium channel subunit Kv2.2, mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNB2 contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNB2 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349719 [Multi-domain]  Cd Length: 127  Bit Score: 75.43  E-value: 2.85e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981  27 LPPAPG--VKASRGDEVLVVNVSGRRFETWKNTLDRYPDTLLG-----SSEKEFF-----YDADSGEYFFDRDPDMFRHV 94
Cdd:cd18412   2 LPPEPVeiIRSKACSRRVKINVGGLNHEVLWRTLDRLPRTRLGklrdcNTHESLLevcddYNLNENEYFFDRHPGAFTSI 81
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 27436981  95 LNFYRTGRLHCPRQECIQAFDEELAFYGLVPELVGDCCLEEYRDRK 140
Cdd:cd18412  82 LNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQKK 127
BTB_POZ_KCNA5 cd18406
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
40-138 3.94e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A member 5 (KCNA5); KCNA5, also called HPCN1, voltage-gated potassium channel HK2, or voltage-gated potassium channel subunit Kv1.5, mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNA5 may play a role in regulating the secretion of insulin in normal pancreatic islets. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNA5 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349713  Cd Length: 97  Bit Score: 74.13  E-value: 3.94e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981  40 EVLVVNVSGRRFETWKNTLDRYPDTLLGSSEKEF-FYDADSGEYFFDRDPDMFRHVLNFYRT-GRLHCPRQECIQAFDEE 117
Cdd:cd18406   1 ERVIINIAGLRFETQLGTLNQFPDTLLGDPDKRMrYFDPLRNEYFFDRNRPSFDGILYFYQSgGKIRRPVNVSIDVFADE 80
                        90       100
                ....*....|....*....|.
gi 27436981 118 LAFYGLvpelvGDCCLEEYRD 138
Cdd:cd18406  81 IRFYQL-----GEEAMERFRE 96
BTB_POZ_KCNA10 cd18409
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
42-123 1.12e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A member 10 (KCNA10); KCNA10, also called voltage-gated potassium channel subunit Kv1.8, is a cyclic nucleotide-gated, voltage-activated potassium channel that mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNA10 is expressed in proximal tubular cells, glomerular and vascular endothelial cells, as well as in vascular smooth muscle cells. It may facilitate proximal tubular sodium absorption by stabilizing cell membrane voltage. The channel activity is up-regulated by cAMP. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNA10 is an alpha subunit that forms functional homotetrameric channels through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349716  Cd Length: 87  Bit Score: 72.57  E-value: 1.12e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981  42 LVVNVSGRRFETWKNTLDRYPDTLLGSSEKEF-FYDADSGEYFFDRDPDMFRHVLNFYRT-GRLHCPRQECIQAFDEELA 119
Cdd:cd18409   3 VIINIAGLRFETQLKTLDQFPDTLLGDPEKRMkYFDSMRNEYFFDRNRPSFDGILYYYQSgGKIRRPANVPLDVFADEII 82

                ....
gi 27436981 120 FYGL 123
Cdd:cd18409  83 FYEL 86
BTB_POZ_KCNA4 cd18405
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
40-138 1.36e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A member 4 (KCNA4); KCNA4 is also called HPCN2, or voltage-gated K(+) channel HuKII, voltage-gated potassium channel HBK4, voltage-gated potassium channel HK1, or voltage-gated potassium channel subunit Kv1.4. It mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNA4 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349712  Cd Length: 97  Bit Score: 72.72  E-value: 1.36e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981  40 EVLVVNVSGRRFETWKNTLDRYPDTLLGSSEKEF-FYDADSGEYFFDRDPDMFRHVLNFYRT-GRLHCPRQECIQAFDEE 117
Cdd:cd18405   1 ERVVINVSGLRFETQLKTLAQFPETLLGDPEKRMrYFDPLRNEYFFDRNRPSFDAILYYYQSgGRLKRPVNVPFDIFSEE 80
                        90       100
                ....*....|....*....|.
gi 27436981 118 LAFYGLvpelvGDCCLEEYRD 138
Cdd:cd18405  81 VKFYEL-----GEEALLKFRE 96
BTB_POZ_Kv9_KCNS cd18384
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
44-136 2.84e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNS/Kv9 subfamily of potassium voltage-gated channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv9, also known as subfamily S, includes KCNS1 (Kv9.1), KCNS2 (Kv9.2) and KCNS3 (Kv9.3). They are regulatory alpha subunits that cannot form functional homo-tetrameric channels. Both KCNS1 and KCNS2 are delayed-rectifier K(+) channel alpha subunits that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2. KCNS3 is a delayed-rectifier K(+) channel alpha subunit linked to tissue oxygenation responses. It can form functional heterotetrameric channels with KCNB1, and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1.


Pssm-ID: 349692  Cd Length: 106  Bit Score: 72.17  E-value: 2.84e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981  44 VNVSGRRFETWKNTLDRYPDTLLG-----SSEKEFF-----YDADSGEYFFDRDPDMFRHVLNFYRTGRLHCPRQECIQA 113
Cdd:cd18384   3 INVGGFRRRLSASALLRFPGTRLGrllacHSEEAILelcddYDVAAREFYFDRNPGFFLYVLHFYRTGKLHVMDELCVFS 82
                        90       100
                ....*....|....*....|...
gi 27436981 114 FDEELAFYGLVPELVGDCCLEEY 136
Cdd:cd18384  83 FSQEIEYWGINEFFLDSCCSYRY 105
BTB_POZ_KCNB1 cd18411
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
44-136 3.49e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily B member 1 (KCNB1); KCNB1, also called delayed rectifier potassium channel 1 (DRK1) or voltage-gated potassium channel subunit Kv2.1, mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNB1 is involved in the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNB1 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349718 [Multi-domain]  Cd Length: 117  Bit Score: 71.96  E-value: 3.49e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981  44 VNVSGRRFETWKNTLDRYPDTLLG-----SSEKEFF-----YDADSGEYFFDRDPDMFRHVLNFYRTGRLHCPRQECIQA 113
Cdd:cd18411  14 LNVGGLAHEVLWRTLDRLPRTRLGklrdcNTHESLMeicddYNLEENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCALS 93
                        90       100
                ....*....|....*....|...
gi 27436981 114 FDEELAFYGLVPELVGDCCLEEY 136
Cdd:cd18411  94 FSQELDYWGIDEIYLESCCQARY 116
BTB_POZ_KCNA1 cd18402
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
40-126 5.56e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A member 1 (KCNA1); KCNA1 is also called voltage-gated K(+) channel HuKI, voltage-gated potassium channel HBK1, or voltage-gated potassium channel subunit Kv1.1. It mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the kidney. It is involved in the regulation of the membrane potential and nerve signaling, and prevents neuronal hyperexcitability. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNA1 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349710  Cd Length: 98  Bit Score: 70.83  E-value: 5.56e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981  40 EVLVVNVSGRRFETWKNTLDRYPDTLLGSSEKEF-FYDADSGEYFFDRDPDMFRHVLNFYRT-GRLHCPRQECIQAFDEE 117
Cdd:cd18402   9 ERVVINIAGLRFETQLKTLAQFPNTLLGNPKKRMrYFDPLRNEYFFDRNRPSFDAILYYYQSgGRLRRPVNVPLDMFSEE 88

                ....*....
gi 27436981 118 LAFYGLVPE 126
Cdd:cd18402  89 IKFYELGEE 97
BTB_POZ_KCNG4 cd18423
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
42-133 7.60e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily G member 4 (KCNG4); KCNG4, also called voltage-gated potassium channel subunit Kv6.4, is a silent voltage-gated potassium (KvS) channel subunit that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNG4 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349730 [Multi-domain]  Cd Length: 112  Bit Score: 71.01  E-value: 7.60e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981  42 LVVNVSGRRFETWKNTLDRYPDTLLG-----SSEKEFF-----YDADSGEYFFDRDPDMFRHVLNFYRTGRLHCPRQECI 111
Cdd:cd18423   4 IIINVGGIKYLMPWSTLDEFPLTRLGklkfcSSYEEIVqicddYDEDTNEFFFDRNPCAFRMIVSFLAAGKLRLLREMCA 83
                        90       100
                ....*....|....*....|..
gi 27436981 112 QAFDEELAFYGLVPELVGDCCL 133
Cdd:cd18423  84 LSFQEELTYWGIEEANLERCCL 105
BTB_POZ_KCNG1_2 cd18421
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
43-139 6.66e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily G members, KCNG1 and KCNG2; KCNG1, also called voltage-gated potassium channel subunit Kv6.1 or kH2, functions as a regulatory alpha-subunit of voltage-gated potassium channel that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. KCNG2, also called cardiac potassium channel subunit or voltage-gated potassium channel subunit Kv6.2, is a new gamma-subunit of voltage-gated potassium channels that can form functional heterodimeric channels with KCNB1, and further modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNG1 and KCNG2 are regulatory alpha subunits and do not form homomultimers. They form heteromultimers (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349728 [Multi-domain]  Cd Length: 114  Bit Score: 68.24  E-value: 6.66e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981  43 VVNVSGRRFETWKNTLDRYPDTLLG-----SSEKEFF-----YDADSGEYFFDRDPDMFRHVLNFYRTGRLHCPRQECIQ 112
Cdd:cd18421   7 IINVGGIKYRIPWTTLEEFPLTRLGqlkscNNFDEIMdicddYDVTCNEFFFDRNPCAFRTILTFLRAGKLRLLREMCAL 86
                        90       100
                ....*....|....*....|....*..
gi 27436981 113 AFDEELAFYGLVPELVGDCCLEEYRDR 139
Cdd:cd18421  87 SFQEELLYWGIEEENLEWCCRRRLLQK 113
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
333-413 8.66e-14

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 66.91  E-value: 8.66e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981   333 LTMAIIIFATVmFYAEKGTNKTNFTSipaAFWYTIVTMTTLGYGDMVPSTIAGKIFGSICSLSGVLVIALPVPVIVSNFS 412
Cdd:pfam07885   2 VLLLVLIFGTV-YYLLEEGWEWSFLD---ALYFSFVTLTTVGYGDIVPLTDAGRLFTIFYILIGIPLFAIFLAVLGRFLT 77

                  .
gi 27436981   413 R 413
Cdd:pfam07885  78 E 78
BTB_POZ_KCTD7 cd18366
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
40-125 3.09e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 7 (KCTD7); KCTD7 is a BTB/POZ domain-containing protein that has an impact on K+ fluxes, neurotransmitter synthesis, and neuronal function. It functions as a regulator of potassium conductance in neurons, and is involved in the control of excitability of cortical neurons. Mutations in KCTD7 may cause progressive myoclonus epilepsy (PME). The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349675  Cd Length: 92  Bit Score: 65.79  E-value: 3.09e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981  40 EVLVVNVSGRRFETWKNTLDRYPDTLLG---SSEKEFFYDADsGEYFFDRDPDMFRHVLNFYRTGRLHcPRQECIQAFDE 116
Cdd:cd18366   4 EVVPLNVGGMHFTTRLSTLRKYEDSMLAamfSGRHHIPKDSE-GRYFIDRDGSYFGYILNFLRDGDLP-PRERARAVYKE 81

                ....*....
gi 27436981 117 ELaFYGLVP 125
Cdd:cd18366  82 AQ-YYGIGP 89
BTB_POZ_KCNV2 cd18425
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
42-139 5.02e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily V member 2 (KCNV2); KCNV2, also called voltage-gated potassium channel subunit Kv8.2, is a modulatory voltage-gated potassium channel alpha subunit that modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. KCNV2 is essential for visual function and cone survival. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNV2 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349732  Cd Length: 108  Bit Score: 65.56  E-value: 5.02e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981  42 LVVNVSGRRFETWKNTLDRYPDTLLGS-------SEKEFF---YDADSGEYFFDRDPDMFRHVLNFYRTGRLHCPRQECI 111
Cdd:cd18425   1 LNINVGGTSYQISYRVAASYPKTRIGRlatytdrSRKLDLcddYNVQNDEYFFDRDPAVFHHIYNFYRTGVLWVKDELCP 80
                        90       100
                ....*....|....*....|....*...
gi 27436981 112 QAFDEELAFYGLVPELVGDCCLEEYRDR 139
Cdd:cd18425  81 RNFLEEINYWGVRIKNTPRCCRISFEER 108
BTB_POZ_KCTD6_like cd18365
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
40-106 9.56e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD6, KCTD21 and similar proteins; KCTD6, also called KCASH3 (KCTD containing, Cullin3 adaptor, suppressor of Hedgehog 3), is a substrate-specific adaptor of cullin-3, effectively regulating protein levels of the muscle small ankyrin-1 isoform 5 (sAnk1.5). KCTD21, also called KCASH2, functions as a substrate-specific adaptor of cullin-3, promoting the ubiquitination and degradation of histone deacetylase HDAC1, thereby inhibiting the deacetylation-mediated transcriptional activation of the Hedgehog effectors Gli1 and Gli2. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349674 [Multi-domain]  Cd Length: 94  Bit Score: 64.34  E-value: 9.56e-13
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27436981  40 EVLVVNVSGRRFETWKNTLDRYPDTLLGSSEKEFFYDA--DSGEYFFDRDPDMFRHVLNFYRTGRLHCP 106
Cdd:cd18365   1 DIVNLNVGGVHYTTTLATLTRFPDSMLGAMFSGSMPTTrdDQGNYFIDRDGTLFRYILNFLRSSQLSLP 69
BTB_POZ_KCTD3-like cd18363
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
39-123 1.29e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 3 (KCTD3) and SH3KBP1-binding protein 1 (SHKBP1); The group of KCTD proteins includes KCTD3 and SHKBP1. KCTD3, also called renal carcinoma antigen NY-REN-45, is a BTB/POZ domain-containing protein that is an accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3), upregulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. SHKBP1, also called SETA-binding protein 1, interacts with cathepsin B and participates in tumor necrosis factor (TNF)-induced apoptosis in ovarian cancer cells. It can promote epidermal growth factor receptor (EGFR) signaling by interrupting c-Cbl-CIN85 complex and inhibiting EGFR degradation. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349672  Cd Length: 86  Bit Score: 63.54  E-value: 1.29e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981  39 DEVLVVNVSGRRFETWKNTLDRYPDTLLGS--SEKEFFYDADSGEYFFDRDPDMFRHVLNFYRTGRLHcPRQECIQAFDE 116
Cdd:cd18363   1 GDIINLNVGGKRFSTSRQTLTWIPDSFFTSllSGRISSLKDETGAIFIDRDPKLFSIILNYLRTKEID-LRNVDISSLRH 79

                ....*..
gi 27436981 117 ELAFYGL 123
Cdd:cd18363  80 EAEFYGI 86
BTB_POZ_FIP2-like cd18376
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
42-123 1.36e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana FH protein interacting protein FIP2 and similar proteins; FIP2 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.


Pssm-ID: 349685  Cd Length: 89  Bit Score: 63.80  E-value: 1.36e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981  42 LVVNVSGRRFETWKNTLDRYPDTLLGS--SEKEFFYDADSGEYFFDRDPDMFRHVLNFYRTGRLHCPRQEcIQAFDE--- 116
Cdd:cd18376   1 VKLNVGGQKFTTTLDTLTKDPDSMLAAmfSGRHSLKKDEDGSYFIDRDGTHFRHILNYLRDGEVKIPTED-RSVLKElle 79

                ....*..
gi 27436981 117 ELAFYGL 123
Cdd:cd18376  80 EAEYYQL 86
BTB_POZ_KCTD6 cd18394
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
42-125 2.30e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 6 (KCTD6); KCTD6, also called KCTD containing, Cullin3 adaptor, suppressor of Hedgehog 3 (KCASH3), is a BTB/POZ domain-containing protein that functions as a substrate-specific adaptor of cullin-3, regulating protein levels of the muscle small ankyrin-1 isoform 5 (sAnk1.5) as well as suppressing histone deacetylase and Hedgehog activity in medulloblastoma. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349702 [Multi-domain]  Cd Length: 104  Bit Score: 63.82  E-value: 2.30e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981  42 LVVNVSGRRFETWKNTLDRYPDTLLGSSEKEFFYDA-DS-GEYFFDRDPDMFRHVLNFYRTGRLHCPRQecIQAFD---E 116
Cdd:cd18394   5 VTLNVGGHLYTTSLSTLTRYPDSMLGAMFRGDFPTArDSqGNYFIDRDGPLFRYILNFLRTSELTLPVD--FKEFDllrK 82

                ....*....
gi 27436981 117 ELAFYGLVP 125
Cdd:cd18394  83 EADFYQIEP 91
BTB_POZ_SHKBP1 cd18393
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
40-139 5.41e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in SH3KBP1-binding protein 1 (SHKBP1); SHKBP1, also called SETA-binding protein 1, interacts with cathepsin B and participates in tumor necrosis factor (TNF)-induced apoptosis in ovarian cancer cells. It can promote epidermal growth factor receptor (EGFR) signaling by interrupting c-Cbl-CIN85 complex and inhibiting EGFR degradation. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349701  Cd Length: 103  Bit Score: 62.65  E-value: 5.41e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981  40 EVLVVNVSGRRFETWKNTLDRYPDTLLGS--SEKEFFYDADSGEYFFDRDPDMFRHVLNFYRTGRLHcPRQECIQAFDEE 117
Cdd:cd18393   2 EVIHLNVGGKRFSTSRQTLTWIPDSFFSSllSGRISTLKDETGAIFIDRDPTVFAPILNFLRTKELD-PRGIHVSLLLHE 80
                        90       100
                ....*....|....*....|..
gi 27436981 118 LAFYGLVPeLVGDCCLEEYRDR 139
Cdd:cd18393  81 AQFYGITP-LVRRLQLCEELDR 101
BTB_POZ_KCNRG cd18375
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
40-125 5.76e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel regulatory protein (KCNRG); KCNRG, also called potassium channel regulator or protein CLLD4, is an endoplasmic reticulum (ER)-associated tumor suppressor that regulates Kv1 family potassium channel proteins by retaining a fraction of the channels in endomembranes. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.


Pssm-ID: 349684  Cd Length: 97  Bit Score: 62.44  E-value: 5.76e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981  40 EVLVVNVSGRRFETWKNTLDRYPDT----LLGSSEKEFfyDADSGEYFFDRDPDMFRHVLNFYRTGRLHCPRQ-ECIQAF 114
Cdd:cd18375   1 ELVTLNVGGKKFTTRPSTLRRFPDSrlarMLDGKDQDF--KVVNGQFFVDRDGSLFSYILDYLRTGQLTLPTEfSDYNRL 78
                        90
                ....*....|.
gi 27436981 115 DEELAFYGLVP 125
Cdd:cd18375  79 AREAEFYGLYS 89
BTB_POZ_KCTD4 cd18364
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
41-123 6.56e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 4 (KCTD4); KCTD4 is a BTB/POZ domain-containing protein with an unknown biological function. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349673 [Multi-domain]  Cd Length: 86  Bit Score: 61.62  E-value: 6.56e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981  41 VLVVNVSGRRFETWKNTLDRYPDTLLGS--SEKEFFYDADSGEYFFDRDPDMFRHVLNFYRTGRLHCPR--QEcIQAFDE 116
Cdd:cd18364   1 LVTLNVGGYLYITQRQTLTKYPDSFLEGmvNGKIQCTVDADGNYFIDRDGLLFRHVLNFLRNGELLLPEgfQE-NQLLAL 79

                ....*..
gi 27436981 117 ELAFYGL 123
Cdd:cd18364  80 EADFYQL 86
BTB_POZ_KCTD11 cd18370
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
42-107 2.11e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein KCTD11; KCTD11 may function as an antagonist of the Hedgehog pathway of cell proliferation and differentiation by affecting the nuclear transfer of transcription factor GLI1, thus maintaining cerebellar granule cells in the undifferentiated state. It is a probable substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. It contains a BTB/POZ domain; in some cases the domain may be truncated. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. Variants of the human/mouse KCTD11 appear to contain truncated BTB/POZ domains.


Pssm-ID: 349679  Cd Length: 88  Bit Score: 60.40  E-value: 2.11e-11
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 27436981  42 LVVNVSGRRFETWKNTLDRYPDTLL------GSSEKEFFYDADSGEYFFDRDPDMFRHVLNFYRTGRLHCPR 107
Cdd:cd18370   1 VTLNVGGTLYSTTLETLTRFPDSMLgamfraGTPIPPNLNMQGGGHYFIDRDGKAFRHILNFLRLGRLDLPR 72
Shal-type pfam11601
Shal-type voltage-gated potassium channels, N-terminal; This family represents the short ...
3-29 2.70e-11

Shal-type voltage-gated potassium channels, N-terminal; This family represents the short N-terminal helical domain of Shal-type voltage-gated potassium channels. The domain interacts with Kv channel-interacting proteins to modulate cell surface expression and the function of Kv4 channels. The interaction of the N-terminus of Shal-type protein Kv4.2 and the Kv interacting protein KChiP1 forms a structure which is like the structure between calmodulin and its target peptides when they interact. Interactions of an N terminal alpha helix in Kv4.2 and a C terminal alpha helix in KChIP1 are essential for the modulation of Kv4.2 by KChIPs.


Pssm-ID: 463305 [Multi-domain]  Cd Length: 28  Bit Score: 58.26  E-value: 2.70e-11
                          10        20
                  ....*....|....*....|....*..
gi 27436981     3 AGLATWLPFARAAAVGWLPLAQQPLPP 29
Cdd:pfam11601   1 ASVAAWLPFARAAAIGWVPVARNPLPP 27
BTB_POZ_KCTD3 cd18392
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
40-125 7.99e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 3 (KCTD3); KCTD3, also called renal carcinoma antigen NY-REN-45, is a BTB/POZ domain-containing protein that is an accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3), upregulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349700  Cd Length: 88  Bit Score: 58.72  E-value: 7.99e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981  40 EVLVVNVSGRRFETWKNTLDRYPDTLLGS--SEKEFFYDADSGEYFFDRDPDMFRHVLNFYRTGRLHcPRQECIQAFDEE 117
Cdd:cd18392   2 EIIQLNVGGTRFSTSRQTLMWIPDSFFSSllSGRISSLKDETGAIFIDRDPTAFVPILNFLRTKELD-LRGVNINVLRHE 80

                ....*...
gi 27436981 118 LAFYGLVP 125
Cdd:cd18392  81 AEFYGITP 88
BTB_POZ_KCTD21 cd18395
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
42-125 9.76e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 21 (KCTD21); KCTD21, also calledz KCTD containing, Cullin3 adaptor, suppressor of Hedgehog 2 (KCASH2), is a BTB/POZ domain-containing protein that functions as a substrate-specific adaptor of cullin-3, promoting the ubiquitination and degradation of histone deacetylase HDAC1, thereby inhibiting the deacetylation-mediated transcriptional activation of the Hedgehog effectors Gli1 and Gli2. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349703 [Multi-domain]  Cd Length: 98  Bit Score: 58.80  E-value: 9.76e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981  42 LVVNVSGRRFETWKNTLDRYPDTLLGSS-EKEFFYDADS-GEYFFDRDPDMFRHVLNFYRTGRLHCPR--QEcIQAFDEE 117
Cdd:cd18395   3 ITLNVGGKLYTTSLATLTRYPDSMLGAMfSGKFPTKKDSqGNCFIDRDGKIFRYILNFLRTSHLDLPEdfQE-MGLLKRE 81

                ....*...
gi 27436981 118 LAFYGLVP 125
Cdd:cd18395  82 ADFYQIQP 89
BTB_POZ_KCTD1-like cd18361
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
44-125 6.44e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD1 and KCTD15; This subfamily of KCTD proteins includes KCTD1 and KCTD15. KCTD1 is a nuclear BTB/POZ domain-containing protein that acts as a transcriptional repressor and mediates protein-protein interactions through a BTB domain. It represses the transcriptional activity of AP-2 family members, including TFAP2A, TFAP2B and TFAP2C. It also functions as a novel inhibitor of the Wnt signaling pathway. Mutations in KCTD1 cause scalp-ear-nipple (SEN) syndrome. KCTD15 is a BTB/POZ domain-containing protein that plays a role in the regulation of neural crest (NC) formation and other steps in embryonic development. It inhibits AP2 transcriptional activity by interaction with its activation domain. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD1 BTB domains form pentamers.


Pssm-ID: 349670  Cd Length: 94  Bit Score: 56.23  E-value: 6.44e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981  44 VNVSGRRFETWKNTLDRYPDTLLG---SSEKEFFYDADSGEYFFDRDPDMFRHVLNFYRTGRLHCPrqECIQAFD---EE 117
Cdd:cd18361   3 IDVGGHIYTSSLETLTKYPESRLGklfNGSIPIVLDSLKQHYFIDRDGKMFRHILNFLRTSKLLLP--DDFTEFDllyEE 80

                ....*...
gi 27436981 118 LAFYGLVP 125
Cdd:cd18361  81 ARYYELQP 88
PRK10537 PRK10537
voltage-gated potassium channel protein;
302-414 7.37e-10

voltage-gated potassium channel protein;


Pssm-ID: 236711 [Multi-domain]  Cd Length: 393  Bit Score: 61.19  E-value: 7.37e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981  302 IFKFSRHSQGLRILGYTLKSCAselgFLLF--------SLT----MAIIIFATVMFYAEKGT------NKTNFTSIPAAF 363
Cdd:PRK10537  98 AITLHFYPWLKFLIGYCIVLLV----ALLIyrrdfdrsSLAagtlFAVISITSLLFYSTFGAlylgdgFSPPIESLSTAF 173
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 27436981  364 WYTIVTMTTLGYGDMVPSTIAGKIFGSICSLSGVLVIA-----LPVPVIVSNFSRI 414
Cdd:PRK10537 174 YFSIVTMSTVGYGDIVPVSESARLFTISVIILGITVFAtsisaIFGPVIRGNLKRL 229
BTB_POZ_KCNG3 cd18422
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
42-142 4.96e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily G member 3 (KCNG3); KCNG3, also called voltage-gated potassium channel subunit Kv6.3 or voltage-gated potassium channel subunit Kv10.1, is an electrically silent modulatory subunit that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further promotes a reduction in the rate of activation and inactivation of the delayed rectifier voltage-gated potassium channel KCNB1. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNG3 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349729  Cd Length: 111  Bit Score: 54.48  E-value: 4.96e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981  42 LVVNVSGRRFETWKNTLDRYPDTLLG-----SSEKEFF-----YDADSGEYFFDRDPDMFRHVLNFYRTGRLHCPRQECI 111
Cdd:cd18422   1 VTLNVGGTRYSFSREVIKDFPLRRVSrlhgcLSEQDVLevcddYDRERNEYFFDRHSEAFGFIMLYVKYGKLRFVPQMCE 80
                        90       100       110
                ....*....|....*....|....*....|.
gi 27436981 112 QAFDEELAFYGLVPELVGDCCLEEYRDRKKE 142
Cdd:cd18422  81 LSFYNEMIYWGLERSHLEYCCQRRLDDRMSD 111
BTB_POZ_KCTD8-like cd18367
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
40-106 6.05e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD8, KCTD12, KCTD16 and similar proteins; This subfamily of KCTD proteins includes KCTD8, KCTD12 (also called predominantly fetal expressed T1 domain/Pfetin), and KCTD16. They act as auxiliary subunits of GABAB receptors associated with mood disorders. KCTD8 interacts as a tetramer with GABRB1 and GABRB2. KCTD12 regulates agonist potency and kinetics of GABAB receptor signaling. It promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition. KCTD16 interacts with amyloid beta precursor protein (APP), a type I transmembrane protein involved in a variety of cellular processes such as cell adhesion, and axon guidance. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349676  Cd Length: 100  Bit Score: 53.83  E-value: 6.05e-09
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 27436981  40 EVLVVNVSGRRFETWKNTLDRYPDTLLGS-----SEKEFFYDAdSGEYFFDRDPDMFRHVLNFYRTGRLHCP 106
Cdd:cd18367   3 EIVELNVGGQVYTTSLSTLIKDPDSLLGRmfsgkNRQELARDS-KGRYFLDRDGVLFRYILDYLRNQKLVLP 73
BTB_POZ_KCTD2-like cd18362
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
45-121 9.40e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins KCTD2, KCTD5, and KCTD17, and similar proteins; This subfamily includes potassium channel tetramerization domain-containing proteins KCTD2, KCTD5, and KCTD17, all of which function as adaptors of Cullin3 based ubiquitin E3 ubiquitin ligases. KCTD2 suppresses gliomagenesis by destabilizing c-Myc. KCTD5 is a negative regulator of the AKT pathway, a key signaling cascade frequently deregulated in cancer. KCTD5 does not impact the operation of Kv4.2, Kv3.4, Kv2.1, or Kv1.2 channels. KCTD17 polyubiquitylates trichoplein, a protein involved in ciliogenesis down-regulation. It is a positive regulator of ciliogenesis, playing a crucial role in the initial steps of axoneme extension. A missense mutation in KCTD17 causes autosomal dominant myoclonus-dystonia (M-D). The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 and KCTD17 BTB domains form pentamer structures.


Pssm-ID: 349671 [Multi-domain]  Cd Length: 85  Bit Score: 52.76  E-value: 9.40e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981  45 NVSGRRFETWKNTLDRYPDTLLG---SSEKEFFYDAD-SGEYFFDRDPDMFRHVLNFYRTGRLHCPRQECIQAFDEELAF 120
Cdd:cd18362   5 NVGGTYFLTTRTTLCRDPKSFLCrlcQEDPDLPSDKDeTGAYLIDRDPTYFGPILNYLRHGKLIIDKDLAEEGVLEEAEF 84

                .
gi 27436981 121 Y 121
Cdd:cd18362  85 Y 85
BTB_POZ_KCTD9 cd18368
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
42-127 4.87e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 9 (KCTD9); KCTD9 is a BTB/POZ domain-containing protein that contributes to liver injury through NK cell activation during hepatitis B virus-induced acute-on-chronic liver failure. It functions as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD9 BTB domain forms a pentameric structure.


Pssm-ID: 349677 [Multi-domain]  Cd Length: 100  Bit Score: 51.11  E-value: 4.87e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981  42 LVVNVSGRRFETWKNTLDRY-PDTLLgssEKEFFYDA-------DSGEYFFDRDPDMFRHVLNFYRTGRLHCPRQECIQA 113
Cdd:cd18368   3 IKLNVGGRIFTTTRSTLVKKePDSML---ARMFSDDStwpssrdENGAYLIDRSPEYFEPILNYLRHGQLILNDGLNPLG 79
                        90
                ....*....|....*..
gi 27436981 114 FDEELAFYG---LVPEL 127
Cdd:cd18368  80 VLEEAKFFGiqsLIEIL 96
BTB_POZ_KCTD15 cd18388
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
44-125 6.79e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 15 (KCTD15); KCTD15 is a BTB/POZ domain-containing protein that plays a role in the regulation of neural crest (NC) formation and other steps in embryonic development. It inhibits AP2 transcriptional activity by interaction with its activation domain. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD1 BTB domains, closely related to KCTD15, form pentamers.


Pssm-ID: 349696  Cd Length: 99  Bit Score: 50.76  E-value: 6.79e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981  44 VNVSGRRFETWKNTLDRYPDTLLG---SSEKEFFYDADSGEYFFDRDPDMFRHVLNFYRTGRLHCPRQ-ECIQAFDEELA 119
Cdd:cd18388   6 IDVGGHMYTSSLATLTKYPDSRISrlfNGTEPIVLDSLKQHYFIDRDGEIFRYILSFLRTSKLLLPEDfKDFNLLYEEAK 85

                ....*.
gi 27436981 120 FYGLVP 125
Cdd:cd18388  86 YYQLQP 91
BTB_3 pfam16017
BTB/POZ domain;
41-106 7.91e-08

BTB/POZ domain;


Pssm-ID: 464976  Cd Length: 106  Bit Score: 50.80  E-value: 7.91e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 27436981    41 VLVVNvsGRRFETWKNTLDRYPDTLLG-----SSEKEFFYDADSGEYFFDR--DPDMFRHVLNFYRTGRLHCP 106
Cdd:pfam16017   3 TLVVD--GTRFVVDPSLFTAHPDTMLGrmfgsSMERNFTRPNEKGEYEIAEgiSSTVFRAILDYYKTGVIRCP 73
BTB_POZ_KCTD14 cd18371
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
41-125 1.03e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 14 (KCTD14); KCTD14 is a BTB/POZ domain-containing protein with unknown biological function. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349680  Cd Length: 99  Bit Score: 50.13  E-value: 1.03e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981  41 VLVVNVSGRRFETWKNTLDRYPDT----LLGSSEKeffYDADS-GEYFFDRDPDMFRHVLNFYRTGRLHCprqECIQAFD 115
Cdd:cd18371   3 VVSLNVGGHIYTTTLSTLRKFPGSklaeLFNGQPK---LRTDSeGRYFIDRDGTYFRYILEYLRTNQVPT---QHIQEVY 76
                        90
                ....*....|
gi 27436981 116 EELAFYGLVP 125
Cdd:cd18371  77 KEALFYDIEP 86
BTB_POZ_KCTD2 cd18389
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
44-124 1.96e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 2 (KCTD2); KCTD2 is a BTB/POZ domain-containing protein that functions as an adaptor of Cullin3 E3 ubiquitin ligase. It suppresses gliomagenesis by destabilizing c-Myc. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 and KCTD17 BTB domain, highly similar to KCTD2, form pentamer structures.


Pssm-ID: 349697 [Multi-domain]  Cd Length: 105  Bit Score: 49.60  E-value: 1.96e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981  44 VNVSGRRFETWKNTLDRYPDTLLG---SSEKEFFYDAD-SGEYFFDRDPDMFRHVLNFYRTGRLHCPRQECIQAFDEELA 119
Cdd:cd18389   5 LNVGGTYFVSTKQTLCRDPKSFLYrlcQEDPDLDSDKDeTGAYLIDRDPTYFGPILNYLRHGKLIINKELAEEGVLEEAE 84

                ....*
gi 27436981 120 FYGLV 124
Cdd:cd18389  85 FYNIA 89
BTB_POZ_KCTD5 cd18390
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
44-140 1.02e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 5 (KCTD5); KCTD5 is a BTB/POZ domain-containing protein that functions as a substrate adaptor for cullin3 based ubiquitin E3 ligases. It is a negative regulator of the AKT pathway, a key signaling cascade frequently deregulated in cancer. KCTD5 does not impact the operation of Kv4.2, Kv3.4, Kv2.1, or Kv1.2 channels. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 forms pentamers mediated by its BTB domain.


Pssm-ID: 349698 [Multi-domain]  Cd Length: 112  Bit Score: 47.68  E-value: 1.02e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981  44 VNVSGRRFETWKNTLDRYPDTLL---GSSEKEFFYDAD-SGEYFFDRDPDMFRHVLNFYRTGRLHCPRQECIQAFDEELA 119
Cdd:cd18390   9 LNVGGTYFLTTRQTLCRDPKSFLyrlCQADPDLDSDKDeTGAYLIDRDPTYFGPVLNYLRHGKLVINKDLAEEGVLEEAE 88
                        90       100
                ....*....|....*....|...
gi 27436981 120 FYGLVP--ELVGDCCLEeyRDRK 140
Cdd:cd18390  89 FYNITSliKLVKDKIRE--RDSK 109
BTB_POZ_KCTD17 cd18391
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
44-125 1.26e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 17 (KCTD17); KCTD17 is a BTB/POZ domain-containing protein that functions as a substrate-adaptor for cullin3-RING ubiquitin ligases that polyubiquitylates trichoplein, a protein involved in ciliogenesis down-regulation. It is a positive regulator of ciliogenesis, playing a crucial role in the initial steps of axoneme extension. A missense mutation in KCTD17 causes autosomal dominant myoclonus-dystonia (M-D). The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD17 BTB domains form pentamers.


Pssm-ID: 349699  Cd Length: 101  Bit Score: 47.29  E-value: 1.26e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981  44 VNVSGRRFETWKNTLDRYPDTLLGS--SEKEFFYDAD-SGEYFFDRDPDMFRHVLNFYRTGRLHCPRQECIQAFDEELAF 120
Cdd:cd18391   5 LNVGGTVFLTTRQTLCREQKSFLSRlcQGEELQSDRDeTGAYLIDRDPTYFGPILNFLRHGKLVLDKDMAEEGVLEEAEF 84

                ....*
gi 27436981 121 YGLVP 125
Cdd:cd18391  85 YNIGP 89
BTB_POZ_KCTD1 cd18387
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
44-128 1.28e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 1 (KCTD1); KCTD1 is a nuclear BTB/POZ domain-containing protein that acts as a transcriptional repressor and mediates protein-protein interactions through a BTB domain. It represses the transcriptional activity of AP-2 family members, including TFAP2A, TFAP2B and TFAP2C to various extent. It also functions as a novel inhibitor of the Wnt signaling pathway. Mutations in KCTD1 cause scalp-ear-nipple (SEN) syndrome. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD1 BTB domains form pentamers.


Pssm-ID: 349695  Cd Length: 105  Bit Score: 47.30  E-value: 1.28e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981  44 VNVSGRRFETWKNTLDRYPDTLLG---SSEKEFFYDADSGEYFFDRDPDMFRHVLNFYRTGRLHCPRQ-ECIQAFDEELA 119
Cdd:cd18387   7 IDVGGHMYTSSLATLTKYPESRIGrlfDGTEPIVLDSLKQHYFIDRDGQMFRYILNFLRTSKLLIPDDfKDYSLLYEEAK 86

                ....*....
gi 27436981 120 FYGLVPELV 128
Cdd:cd18387  87 YFQLQPMLL 95
BTB_POZ_KCTD8 cd18396
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
40-109 3.18e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein KCTD8; KCTD8, a BTB/POZ domain-containing protein, is an auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. It interacts as a tetramer with GABRB1 and GABRB2. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349704 [Multi-domain]  Cd Length: 103  Bit Score: 43.25  E-value: 3.18e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27436981  40 EVLVVNVSGRRFETWKNTLDRYPDTLL-----GSSEKEFFYDaDSGEYFFDRDPDMFRHVLNFYRTGRL----HCPRQE 109
Cdd:cd18396   4 EVVELNVGGQVYVTKHSTLLSVPDSTLasmfsRRAARELPRD-NRGRFFIDRDGFLFRYVLDYLRDKQLalpdHFPEKE 81
BTB_POZ_KCTD20-like cd18318
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
46-125 3.73e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 20 (KCTD20) and BTB/POZ domain-containing protein 10 (BTBD10); KCTD20, also termed potassium channel tetramerization domain containing 20, is a positive regulator of Akt signaling. It may play an important role in regulating the death and growth of some non-nervous and nervous cells. BTBD10, also termed glucose metabolism-related protein 1 (GMRP1), plays a major role as an activator of AKT family members. It binds to Akt and protein phosphatase 2A (PP2A) and inhibits the PP2A-mediated dephosphorylation of Akt, thereby keeping Akt activated. It also plays a role in preventing motor neuronal death and accelerating the growth of pancreatic beta cells.


Pssm-ID: 349627  Cd Length: 92  Bit Score: 42.69  E-value: 3.73e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981  46 VSGRRFETWKNTLDRYPDTLLG-----SSEKEFFYDADSGEYFFDR--DPDMFRHVLNFYRTGRLHCPR----QECIQAF 114
Cdd:cd18318   7 VDGTRFVVDPSLFTAHPDTMLGrmfgsGLENNFTRPNERGEYEVADgiSATVFRAILDYYKTGIIRCPPsvsvAELREAC 86
                        90
                ....*....|.
gi 27436981 115 DeelafYGLVP 125
Cdd:cd18318  87 D-----YLLIP 92
BTB_POZ_KCTD16 cd18398
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
40-128 6.36e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 16 (KCTD16); KCTD16 is a BTB/POZ domain-containing protein that is an auxiliary subunit of GABAB receptors associated with mood disorders. It interacts with amyloid beta precursor protein (APP), a type I transmembrane protein involved in a variety of cellular processes such as cell adhesion and axon guidance. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349706 [Multi-domain]  Cd Length: 103  Bit Score: 42.59  E-value: 6.36e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981  40 EVLVVNVSGRRFETWKNTLDRYPDTLLG---SSEKEFFYD--ADS-GEYFFDRDPDMFRHVLNFYRTGRLHCPRQECIQA 113
Cdd:cd18398   3 EVVELNVGGQVYFTRHATLVSIPHSLLWkmfSPKRDTANDlaKDSkGRFFIDRDGFLFRYILDYLRDRQVVLPDHFPEKG 82
                        90
                ....*....|....*
gi 27436981 114 FDEELAFYGLVPELV 128
Cdd:cd18398  83 RLKREAEYFQLPDLV 97
BTB_POZ_KCTD20 cd18386
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
40-106 1.71e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 20 (KCTD20); KCTD20, also called potassium channel tetramerization domain containing 20, is a positive regulator of Akt signaling. It may play an important role in regulating the death and growth of some non-nervous and nervous cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349694  Cd Length: 104  Bit Score: 41.10  E-value: 1.71e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27436981  40 EVLVVNVSGRRFETWKNTLDRYPDTLLG-----SSEKEFFYDADSGEYFFDR--DPDMFRHVLNFYRTGRLHCP 106
Cdd:cd18386   3 EKVTLIVDGTRFVVNPQIFTAHPDTMLGrmfgpGREYNFTRPNEKGEYEIAEgiSCTVFRTVLDYYKTGIINCP 76
BTB_POZ_KCTD12_Pfetin cd18397
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
40-106 1.77e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 12 (KCTD12); KCTD12, also called predominantly fetal expressed T1 domain (Pfetin), is a BTB/POZ domain-containing protein that is an auxiliary subunit of GABAB receptors associated with mood disorders. It regulates agonist potency and kinetics of GABAB receptor signaling. It promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition. It also regulates colorectal cancer cell stemness through the ERK pathway. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349705 [Multi-domain]  Cd Length: 100  Bit Score: 41.02  E-value: 1.77e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 27436981  40 EVLVVNVSGRRFETWKNTLDRYPDTLL-----GSSEKEFFYDAdSGEYFFDRDPDMFRHVLNFYRTGRLHCP 106
Cdd:cd18397   3 EIVELNVGGQVYVTRHTTLVSVPDSLLwhmfsQQKPGELARDS-KGRFFLDRDGFLFRYILDYLRDLQLVLP 73
BTB2_POZ_KCTD19 cd18374
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
40-106 1.81e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 19 (KCTD19); KCTD19 is a BTB/POZ domain-containing protein with unclear biological function. It may be a host factor involved in Nef-induced downregulation of MHC-I. Nef is a HIV-1-encoded protein that plays a key role in the development of AIDS. KCTD19 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349683  Cd Length: 99  Bit Score: 40.95  E-value: 1.81e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 27436981  40 EVLVVNVSGRRFETWKNTLDRYPDTLlgSSEKEFFYDADSGEYFFDRDPDMFRHVLNFYRTGRLHCP 106
Cdd:cd18374   1 QIVKVYVGSHWYATYLKTLLKYPELL--SNSKKVRWITYGQTLLISGDGQMFRHILNFLRLGKLLLP 65
BTB_POZ_KCTD18 cd18372
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
40-123 2.84e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 18 (KCTD18); KCTD18 is a BTB/POZ domain-containing protein with with unknown biological function. A duplication of the KCTD18 gene has been found in a patient with epilepsy, developmental delay, and autistic behavior, which may contribute to the phenotype. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349681  Cd Length: 101  Bit Score: 40.56  E-value: 2.84e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981  40 EVLVVNVSGRRFETWKNTLDRYPDTLLGS--SEKEFFYDADSGEYFFDRDPDMFRHVLNfYRTGRLHCPRQECIQ-AFDE 116
Cdd:cd18372   1 DVLRLNVGGCIYTARRESLCRFKDSMLSSmfSGRFPLKLDESGACVIDRDGRLFKYLLD-YLHGELQIPEDEQTRlALQE 79

                ....*..
gi 27436981 117 ELAFYGL 123
Cdd:cd18372  80 EADYFGI 86
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region from group II of ...
301-401 5.09e-04

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 41.88  E-value: 5.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981   301 RIFKFSRHSQGLRILGYTLKSCASEL---GFLLFSLTMAIIIFATVMFyaekGTNKTNFTSIPAAfwytIVTMTTLGYGD 377
Cdd:pfam08016 110 KLFKVLRFNKTMSLFTKTLSRAWKDLagfALMFVIFFFAYAQFGYLLF----GTQAPNFSNFVKS----ILTLFRTILGD 181
                          90       100
                  ....*....|....*....|....*.
gi 27436981   378 MVPSTI--AGKIFGSICSLSGVLVIA 401
Cdd:pfam08016 182 FGYNEIfsGNRVLGPLLFLTFVFLVI 207
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
258-388 5.83e-03

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 39.85  E-value: 5.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436981  258 RFLrSVMSLIDVVAILPYY-IGLLVPKNDDVSGAFVTLRVFRVFRIFK----FSRHSQGLRiLGYTLKSCASelgflLFS 332
Cdd:PLN03192 135 RYL-STWFLMDVASTIPFQaLAYLITGTVKLNLSYSLLGLLRFWRLRRvkqlFTRLEKDIR-FSYFWIRCAR-----LLS 207
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27436981  333 LTMAIIIFATVMFY--------AEK---GTNKTNFTS-------IPAAFWyTIVTMTTLGYGDMVPSTIAGKIF 388
Cdd:PLN03192 208 VTLFLVHCAGCLYYliadryphQGKtwiGAVIPNFREtslwiryISAIYW-SITTMTTVGYGDLHAVNTIEMIF 280
BTB1_POZ_KCTD19 cd18373
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
45-103 5.83e-03

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 19 (KCTD19); KCTD19 is a BTB/POZ domain-containing protein with unclear biological function. It may be a host factor involved in Nef-induced downregulation of MHC-I. Nef is a HIV-1-encoded protein that plays a key role in the development of AIDS. KCTD19 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349682  Cd Length: 98  Bit Score: 36.68  E-value: 5.83e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 27436981  45 NVSGRRFETWKNTLDRYPDTLLgSSEKEFFYDADSGEYFFDRDPDMFRHVLNFYRTGRL 103
Cdd:cd18373   4 NVGGWIFSVPKSKLAQFPDSLL-WKEASSLSESENTRLFIDRDGFTFRHVHYYLQTSKL 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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