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Conserved domains on  [gi|84105335|ref|NP_005915|]
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homeobox protein MOX-2 [Homo sapiens]

Protein Classification

homeobox domain-containing protein( domain architecture ID 13432619)

homeobox domain-containing protein may be involved in the transcriptional regulation of key eukaryotic developmental processes

CATH:  1.10.10.60
Gene Ontology:  GO:0000981|GO:0043565
PubMed:  8768896|12520008|11470884
SCOP:  4000291

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
188-244 3.30e-30

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 108.36  E-value: 3.30e-30
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 84105335   188 RKERTAFTKEQIRELEAEFAHHNYLTRLRRYEIAVNLDLTERQVKVWFQNRRMKWKR 244
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
COG5576 super family cl35021
Homeodomain-containing transcription factor [Transcription];
160-284 2.90e-10

Homeodomain-containing transcription factor [Transcription];


The actual alignment was detected with superfamily member COG5576:

Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 57.83  E-value: 2.90e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84105335 160 EKRSGGKRKSDSSDSQEGNYKSEVN-SKPRKERTAFTKEQIRELEAEFAHHNYLTRLRRYEIAVNLDLTERQVKVWFQNR 238
Cdd:COG5576  23 IKTTKNKREVEAADSEMKLERKQDGsSPPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNK 102

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 84105335 239 RMKWKRVKGGQQGAAAREKELVNVKKGTLLPSELSGIGAATLQQTG 284
Cdd:COG5576 103 RAKEKKKRSGKVEQRPGEEEADLAKIGSLSTGQISIIETLEFSRTS 148
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
188-244 3.30e-30

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 108.36  E-value: 3.30e-30
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 84105335   188 RKERTAFTKEQIRELEAEFAHHNYLTRLRRYEIAVNLDLTERQVKVWFQNRRMKWKR 244
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 187-243 5.70e-27

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 100.02  E-value: 5.70e-27
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 84105335    187 PRKERTAFTKEQIRELEAEFAHHNYLTRLRRYEIAVNLDLTERQVKVWFQNRRMKWK 243
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 188-246 9.89e-26

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 96.93  E-value: 9.89e-26
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 84105335 188 RKERTAFTKEQIRELEAEFAHHNYLTRLRRYEIAVNLDLTERQVKVWFQNRRMKWKRVK 246
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
160-284 2.90e-10

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 57.83  E-value: 2.90e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84105335 160 EKRSGGKRKSDSSDSQEGNYKSEVN-SKPRKERTAFTKEQIRELEAEFAHHNYLTRLRRYEIAVNLDLTERQVKVWFQNR 238
Cdd:COG5576  23 IKTTKNKREVEAADSEMKLERKQDGsSPPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNK 102

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 84105335 239 RMKWKRVKGGQQGAAAREKELVNVKKGTLLPSELSGIGAATLQQTG 284
Cdd:COG5576 103 RAKEKKKRSGKVEQRPGEEEADLAKIGSLSTGQISIIETLEFSRTS 148
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
188-244 3.30e-30

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 108.36  E-value: 3.30e-30
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 84105335   188 RKERTAFTKEQIRELEAEFAHHNYLTRLRRYEIAVNLDLTERQVKVWFQNRRMKWKR 244
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 187-243 5.70e-27

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 100.02  E-value: 5.70e-27
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 84105335    187 PRKERTAFTKEQIRELEAEFAHHNYLTRLRRYEIAVNLDLTERQVKVWFQNRRMKWK 243
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 188-246 9.89e-26

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 96.93  E-value: 9.89e-26
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 84105335 188 RKERTAFTKEQIRELEAEFAHHNYLTRLRRYEIAVNLDLTERQVKVWFQNRRMKWKRVK 246
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
160-284 2.90e-10

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 57.83  E-value: 2.90e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84105335 160 EKRSGGKRKSDSSDSQEGNYKSEVN-SKPRKERTAFTKEQIRELEAEFAHHNYLTRLRRYEIAVNLDLTERQVKVWFQNR 238
Cdd:COG5576  23 IKTTKNKREVEAADSEMKLERKQDGsSPPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNK 102

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 84105335 239 RMKWKRVKGGQQGAAAREKELVNVKKGTLLPSELSGIGAATLQQTG 284
Cdd:COG5576 103 RAKEKKKRSGKVEQRPGEEEADLAKIGSLSTGQISIIETLEFSRTS 148
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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