N-terminal sub-domain of the Rel homology domain (RHD) of the reticuloendotheliosis viral oncogene homolog B (RelB) protein; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the RelB family of transcription factors, categorized as class II NF-kappa B family members. In class II NF-kappa Bs, the RHD domain co-occurs with a C-terminal transactivation domain (TAD). NF-kappa B proteins are part of a protein complex that acts as a transcription factor, which is responsible for regulating a host of cellular responses to a variety of stimuli. This complex tightly regulates the expression of a large number of genes, and is involved in processes such as adaptive and innate immunity, stress response, inflammation, cell adhesion, proliferation and apoptosis. The cytosolic NF-kappa B complex is activated via phosphorylation of the ankyrin-repeat containing inhibitory protein I-kappa B, which dissociates from the complex and exposes the nuclear localization signal of the heterodimer (NF-kappa B and Rel). RelB, is unable to homodimerize but is a potent transactivator in a heterodimer with NF-kappa B1 (p50) or B2 (p52). It is involved in the regulation of genes that play roles in inflammatory processes and the immune response.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35493878 125 PHLVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGLREVEVTACLVWKDWPHRVHPHSLVGKDCT 204
Cdd:cd07886   1 PRLLITEQPKQRGMRFRYECEGRSAGSILGESSTEANKTQPAIEIQNCIGLKEVTVTVCLVWKDPPHRVHPHGLVGKDCP 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35493878 205 DGICRVRLRPHVSPRHSFNNLGIQCVRKKEIEAAIERKIQLGIDPYNAGSLKNHQEVDMNVVRICFQASYRDQQGQMRRM 284
Cdd:cd07886  81 NGICQVTLNPHSSPRHSFSNLGIQCVRKREIEAAIETRLQLNIDPFKAGSLKNHEEVDMNVVRLCFQASYRDDDGRKDCL 160

                       170
                ....*....|..
gi 35493878 285 DPVLSEPVYDKK 296
Cdd:cd07886 161 SPVLSEPIYDKK 172

Rel homology dimerization domain; The Rel homology domain (RHD) is composed of two structural domains, an N-terminal DNA_binding domain (pfam00554) and a C-terminal dimerization domain. This is the dimerization domain.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35493878   304 RICRINKESGPCTGGEELYLLCDKVQKEDISVVFS-----RASWEGRADFSQADVHRQIAIVFKTPPYEDLEIVEPVTVN 378
Cdd:pfam16179   1 KICRLSLCSGSVTGGEEIILLCEKVLKDDIKVRFYeeddgQEVWEAEGDFSKTDVHRQVAIVFKTPPYRDPDITEPVTVN 80

                          90       100
                  ....*....|....*....|..
gi 35493878   379 VFLQRLTDGVCSEPLPFTYLPR 400
Cdd:pfam16179  81 IQLRRPSDKATSEPQPFTYLPL 102

N-terminal sub-domain of the Rel homology domain (RHD) of the reticuloendotheliosis viral oncogene homolog B (RelB) protein; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the RelB family of transcription factors, categorized as class II NF-kappa B family members. In class II NF-kappa Bs, the RHD domain co-occurs with a C-terminal transactivation domain (TAD). NF-kappa B proteins are part of a protein complex that acts as a transcription factor, which is responsible for regulating a host of cellular responses to a variety of stimuli. This complex tightly regulates the expression of a large number of genes, and is involved in processes such as adaptive and innate immunity, stress response, inflammation, cell adhesion, proliferation and apoptosis. The cytosolic NF-kappa B complex is activated via phosphorylation of the ankyrin-repeat containing inhibitory protein I-kappa B, which dissociates from the complex and exposes the nuclear localization signal of the heterodimer (NF-kappa B and Rel). RelB, is unable to homodimerize but is a potent transactivator in a heterodimer with NF-kappa B1 (p50) or B2 (p52). It is involved in the regulation of genes that play roles in inflammatory processes and the immune response.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35493878 125 PHLVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGLREVEVTACLVWKDWPHRVHPHSLVGKDCT 204
Cdd:cd07886   1 PRLLITEQPKQRGMRFRYECEGRSAGSILGESSTEANKTQPAIEIQNCIGLKEVTVTVCLVWKDPPHRVHPHGLVGKDCP 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35493878 205 DGICRVRLRPHVSPRHSFNNLGIQCVRKKEIEAAIERKIQLGIDPYNAGSLKNHQEVDMNVVRICFQASYRDQQGQMRRM 284
Cdd:cd07886  81 NGICQVTLNPHSSPRHSFSNLGIQCVRKREIEAAIETRLQLNIDPFKAGSLKNHEEVDMNVVRLCFQASYRDDDGRKDCL 160

                       170
                ....*....|..
gi 35493878 285 DPVLSEPVYDKK 296
Cdd:cd07886 161 SPVLSEPIYDKK 172

Rel homology DNA-binding domain; Proteins containing the Rel homology domain (RHD) are eukaryotic transcription factors. The RHD is composed of two structural domains. This is the N-terminal DNA-binding domain that is similar to that found in P53. The C-terminal domain has an immunoglobulin-like fold (See pfam16179) that functions as a dimerization domain.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35493878   127 LVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGlrEVEVTACLVWKDWPHRVHPHSLVGKDCTDG 206
Cdd:pfam00554   1 LEIVEQPKQRGMRFRYKCEGRSAGSIPGESSTRSKKTFPTVQICNYDG--PAVIRVSLVTKDEPHRPHPHSLVGKDCKDG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35493878   207 ICRVRLRPHvSPRHSFNNLGIQCVRKKEIEAAIERKIQLGIDPYN--AGSLKNHQEVDMNVVRICFQASYRDQQGQ-MRR 283
Cdd:pfam00554  79 VCEVELGPE-DMVASFQNLGIQCVKKKDVEEALKERIELNIDPFNvgFEALRQIKDMDLNVVRLCFQAFLPDTRGNfTTP 157

                         170
                  ....*....|..
gi 35493878   284 MDPVLSEPVYDK 295
Cdd:pfam00554 158 LPPVVSNPIYDK 169

IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to certain chemicals. NFkappaB blocking cell apoptosis in several cell types, gives it an important role in cell proliferation and differentiation.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35493878 303 LRICRINKESGPCTGGEELYLLCDKVQKEDISVVF-----SRASWEGRADFSQADVHRQIAIVFKTPPYEDLEIVEPVTV 377
Cdd:cd01177   1 LKICRLDKTSGSVKGGDEVYLLCDKVQKEDIQVRFfeedeEETVWEAFGDFSQTDVHRQYAIVFRTPPYHDPDITEPVKV 80

                        90       100
                ....*....|....*....|..
gi 35493878 378 NVFLQRLTDGVCSEPLPFTYLP 399
Cdd:cd01177  81 KIQLKRPSDGERSESVPFTYVP 102

ig-like, plexins, transcription factors;

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35493878    302 ELRICRINKESGPCTGGEELyLLCDKVQKEDISVVFSRASWEGRADFSQAdvhRQIAIVFKTPPYEDLEIVEPVTvNVFL 381
Cdd:smart00429   1 DPVITRISPTSGPVSGGTEI-TLCGKNLKSISVVFVEVGVGEAPCTFSPS---SSTAIVCKTPPYHNIPGSVPVR-TVGL 75

                           90
                   ....*....|....*..
gi 35493878    382 QRltDGVCSEPLPFTYL 398
Cdd:smart00429  76 RN--GGVPSSPQPFTYV 90

N-terminal sub-domain of the Rel homology domain (RHD) of the reticuloendotheliosis viral oncogene homolog B (RelB) protein; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the RelB family of transcription factors, categorized as class II NF-kappa B family members. In class II NF-kappa Bs, the RHD domain co-occurs with a C-terminal transactivation domain (TAD). NF-kappa B proteins are part of a protein complex that acts as a transcription factor, which is responsible for regulating a host of cellular responses to a variety of stimuli. This complex tightly regulates the expression of a large number of genes, and is involved in processes such as adaptive and innate immunity, stress response, inflammation, cell adhesion, proliferation and apoptosis. The cytosolic NF-kappa B complex is activated via phosphorylation of the ankyrin-repeat containing inhibitory protein I-kappa B, which dissociates from the complex and exposes the nuclear localization signal of the heterodimer (NF-kappa B and Rel). RelB, is unable to homodimerize but is a potent transactivator in a heterodimer with NF-kappa B1 (p50) or B2 (p52). It is involved in the regulation of genes that play roles in inflammatory processes and the immune response.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35493878 125 PHLVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGLREVEVTACLVWKDWPHRVHPHSLVGKDCT 204
Cdd:cd07886   1 PRLLITEQPKQRGMRFRYECEGRSAGSILGESSTEANKTQPAIEIQNCIGLKEVTVTVCLVWKDPPHRVHPHGLVGKDCP 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35493878 205 DGICRVRLRPHVSPRHSFNNLGIQCVRKKEIEAAIERKIQLGIDPYNAGSLKNHQEVDMNVVRICFQASYRDQQGQMRRM 284
Cdd:cd07886  81 NGICQVTLNPHSSPRHSFSNLGIQCVRKREIEAAIETRLQLNIDPFKAGSLKNHEEVDMNVVRLCFQASYRDDDGRKDCL 160

                       170
                ....*....|..
gi 35493878 285 DPVLSEPVYDKK 296
Cdd:cd07886 161 SPVLSEPIYDKK 172

N-terminal sub-domain of the Rel homology domain (RHD); Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal sub-domain, which may be distantly related to the DNA-binding domain found in P53. The C-terminal sub-domain has an immunoglobulin-like fold and serves as a dimerization module that also binds DNA (see cd00102). The RHD is found in NF-kappa B, nuclear factor of activated T-cells (NFAT), the tonicity-responsive enhancer binding protein (TonEBP), and the arthropod proteins Dorsal and Relish (Rel).

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35493878 125 PHLVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGlrEVEVTACLVWKDWPHRVHPHSLVGK-DC 203
Cdd:cd07827   1 PYLEITEQPKQRGHRFRYECEGRSAGSIPGENSTADRKTFPTVKLRNYNG--PAKIVVSLVTKDDPPKPHPHQLVGKtDC 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35493878 204 TDGICRVRLRPHVSPRHSFNNLGIQCVRKKEIEAAIERKIQLGIDPY--NAGSLKNHQEVDMNVVRICFQASYRDQQGQM 281
Cdd:cd07827  79 RDGVCEVRLGPKNNMTASFNNLGIQCVRKKDVEEALGQRIQLGIDPFmvHKGPEGNASDIDLNRVRLCFQAFIEDSDGGF 158

                       170
                ....*....|....*.
gi 35493878 282 R-RMDPVLSEPVYDKK 296
Cdd:cd07827 159 TlPLPPVLSNPIYDKK 174

N-terminal sub-domain of the Rel homology domain (RHD) of RelA; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD domain of the RelA family of transcription factors, categorized as a class II member of the NF-kappa B family. In class II NF-kappa Bs, the RHD domain co-occurs with a C-terminal transactivation domain (TAD). NF-kappa B proteins are part of a protein complex that acts as a transcription factor, which is responsible for regulating a host of cellular responses to a variety of stimuli. This complex tightly regulates the expression of a large number of genes, and is involved in processes such as adaptive and innate immunity, stress response, inflammation, cell adhesion, proliferation and apoptosis. The cytosolic NF-kappa B complex is activated via phosphorylation of the ankyrin-repeat containing inhibitory protein I-kappa B, which dissociates from the complex and exposes the nuclear localization signal of the heterodimer (NF-kappa B and Rel). RelA (also called p65) forms heterodimers with NF-kappa B1 (p50) and B2 (p52). RelA also forms homodimers.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35493878 125 PHLVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGLREVEVTacLVWKDWPHRVHPHSLVGKDCT 204
Cdd:cd07885   1 PYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINNYTGPGRVRIS--LVTKDPPHKPHPHELVGKDCK 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35493878 205 DGICRVRLRPHVSPrHSFNNLGIQCVRKKEIEAAIERKIQLGIDPYNAGSLKNHQEVDMNVVRICFQASYRDQQGQMRRM 284
Cdd:cd07885  79 DGYYEAELSPDRCI-HSFQNLGIQCVKKRDLEQAVSQRIQTNNNPFNVPIEEQRADYDLNAVRLCFQVTVRDPSGRLLPL 157

                       170
                ....*....|..
gi 35493878 285 DPVLSEPVYDKK 296
Cdd:cd07885 158 PPVLSQPIYDNR 169

N-terminal sub-domain of the Rel homology domain (RHD) of c-Rel; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the c-Rel family of transcription factors, categorized as a class II member of the NF-kappa B family. In class II NF-kappa Bs, the RHD domain co-occurs with a C-terminal transactivation domain (TAD). NF-kappa B proteins are part of a protein complex that acts as a transcription factor, which is responsible for regulating a host of cellular responses to a variety of stimuli. This complex tightly regulates the expression of a large number of genes, and is involved in processes such as adaptive and innate immunity, stress response, inflammation, cell adhesion, proliferation and apoptosis. The cytosolic NF-kappa B complex is activated via phosphorylation of the ankyrin-repeat containing inhibitory protein I-kappa B, which dissociates from the complex and exposes the nuclear localization signal of the heterodimer (NF-kappa B and Rel). c-Rel plays an important role in B cell proliferation and survival.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35493878 125 PHLVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGLREVEVTacLVWKDWPHRVHPHSLVGKDCT 204
Cdd:cd07933   1 PYVEIFEQPRQRGMRFRYKCEGRSAGSIPGERSTDNNRTYPSIQILNYTGKGKVRIT--LVTKNEPYKPHPHDLVGKDCR 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35493878 205 DGICRVRLRPHVSPRhSFNNLGIQCVRKKEIEAAIERKIQLGIDPYNAG--SLKNHQEVDMNVVRICFQASYRDQQGQMR 282
Cdd:cd07933  79 DGYYEAEFGPERRVL-AFQNLGIQCVRRREVKEAIMLRISRGINPFNVPeeQLLQIEEYDLNVVRLCFQIFLPDEHGNYT 157

                       170
                ....*....|....*
gi 35493878 283 RM-DPVLSEPVYDKK 296
Cdd:cd07933 158 TAlPPIVSNPIYDNR 172

IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to certain chemicals. NFkappaB blocking cell apoptosis in several cell types, gives it an important role in cell proliferation and differentiation.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35493878 303 LRICRINKESGPCTGGEELYLLCDKVQKEDISVVF-----SRASWEGRADFSQADVHRQIAIVFKTPPYEDLEIVEPVTV 377
Cdd:cd01177   1 LKICRLDKTSGSVKGGDEVYLLCDKVQKEDIQVRFfeedeEETVWEAFGDFSQTDVHRQYAIVFRTPPYHDPDITEPVKV 80

                        90       100
                ....*....|....*....|..
gi 35493878 378 NVFLQRLTDGVCSEPLPFTYLP 399
Cdd:cd01177  81 KIQLKRPSDGERSESVPFTYVP 102

IPT domain of eukaryotic transcription factors NF-kappaB/Rel, nuclear factor of activated Tcells (NFAT), and recombination signal J-kappa binding protein (RBP-Jkappa). The IPT domains in these proteins are involved in DNA binding. Most NF-kappaB/Rel proteins form homo- and heterodimers, while NFAT proteins are largely monomeric (with TonEBP being an exception). While the majority of sequence-specific DNA binding elements are found in the N-terminal domain, several are found in the IPT domain in loops adjacent to, and including, the linker region.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35493878 303 LRICRINKESGPCTGGEELYLLCDKVQKEDISVVF-----SRASWEGRADFSQADVHrQIAIVFKTPPYEDLEIVEPVTV 377
Cdd:cd00602   1 LPICRVSSLSGSVNGGDEVFLLCDKVNKPDIKVWFgekgpGETVWEAEAMFRQEDVR-QVAIVFKTPPYHNKWITRPVQV 79

                        90       100
                ....*....|....*....|..
gi 35493878 378 NVFLQRLTDGVCSEPLPFTYLP 399
Cdd:cd00602  80 PIQLVRPDDRKRSEPLTFTYTP 101

N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1); Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the NF-kappa B1 family of transcription factors, a class I member of the NF-kappa B family. In class I NF-kappa Bs, the RHD domain co-occurs with C-terminal ankyrin repeats. NF-kappa B1 is commonly referred to as p105 or p50 (proteolytically processed form). NF-kappa B proteins are part of a protein complex that acts as a transcription factor, which is responsible for regulating a host of cellular responses to a variety of stimuli. This complex tightly regulates the expression of a large number of genes, and is involved in processes such as adaptive and innate immunity, stress response, inflammation, cell adhesion, proliferation and apoptosis. The cytosolic NF-kappa B complex is activated via phosphorylation of the ankyrin-repeat containing inhibitory protein I-kappa B, which dissociates from the complex and exposes the nuclear localization signal of the heterodimer (NF-kappa B and REL). NF-kappa B1 is involved in the canonical NF-kappa B signaling pathway which is activated by many agonists and is essential in immune and inflammatory responses, as well as cell survival. p105 is involved in its own specific NF-kappa B signaling pathway which is also implicated in immune and inflammatory responses. p105 may also act as an I-kappa B due to its C-terminal ankyrin repeats. It is also involved in mitogen-activated protein kinase (MAPK) signaling as its degradation leads to the activation of TPL-2, a MAPK kinase kinase which activates ERK pathways.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35493878 125 PHLVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTLPAIELrdCGGLREVEVTACLVWKDWPHRVHPHSLVGKDCT 204
Cdd:cd07935   1 PYLQILEQPKQRGFRFRYVCEGPSHGGLPGASSEKNKKSYPQVKI--CNYVGPAKVIVQLVTNGKNIHLHAHSLVGKHCE 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35493878 205 DGICRVRLRPHVSPRhSFNNLGIQCVRKKEIEAAIE-RKIQLGIDPYNAG------------------SLKNHQ------ 259
Cdd:cd07935  79 DGICTVTAGPKDMVV-GFANLGILHVTKKKVFETLEaRMTEACKKGYNPGllvhpelaylqaegggdrQLTEREkeiirq 157

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 35493878 260 -------EVDMNVVRICFQASYRDQQGQM-RRMDPVLSEPVYDKK 296
Cdd:cd07935 158 aavqqtkEMDLSVVRLMFTAFLPDSTGGFtRRLEPVVSDAIYDSK 202

N-terminal sub-domain of the Rel homology domain (RHD) of the arthropod protein Relish; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the arthropod Relish protein, in which the RHD domain co-occurs with C-terminal ankyrin repeats. Family members are sometimes referred to as p110 or p68 (proteolytically processed form). Relish is an NF-kappa B-like transcription factor, which plays a role in mediating innate immunity in Drosophila. It is activated via the Imd (immune deficiency) pathway, which triggers phosphorylation of Relish. IKK-dependent proteolytic cleavage of Relish (which involves Dredd) results in a smaller active form (without the C-terminal ankyrin repeats), which is transported into the nucleus and functions as a transactivator.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35493878 125 PHLVITEQPKQRgMRFRYECEGR-SAGSILGESSTEASKTLPAIELRDCGGlrEVEVTACLV-WKDWPHRVHPHSLVGKD 202
Cdd:cd07884   1 PFLRIVEQPVDK-FRFRYKSEMHgTHGSLLGERSTSSKKTFPTVKLCNYRG--QAVIRCSLYqADDNRRKPHVHKLVGKQ 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35493878 203 CTDGICRVRLrPHVSPRH----SFNNLGIQCVRKKEIEAAIERKiqlgidpynagslKNhqeVDMNVVRICFQASYRDQQ 278
Cdd:cd07884  78 GDDDVCDPHD-IEVSPEGdyvaMFQNMGIIHTAKKNIPEELYKK-------------KN---MNLNQVVLRFQAFAVSAN 140

                       170
                ....*....|....*....
gi 35493878 279 GQMRRM-DPVLSEPVYDKK 296
Cdd:cd07884 141 GHLRPIcPPVYSNPINNLK 159

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35493878 303 LRICRINKESGPCTGGEELYLLCDKVQKE-DISVVFSrasweGRADFSQADVHrQIAIVFKTPPYEDLeivEPVTVNVFL 381
Cdd:cd00102   1 PVITSISPSSGPVSGGTEVTITGSNFGSGsNLRVTFG-----GGVPCSVLSVS-STAIVCTTPPYANP---GPGPVEVTV 71

                        90
                ....*....|....*...
gi 35493878 382 QRLTDGVCSEPLPFTYLP 399
Cdd:cd00102  72 DRGNGGITSSPLTFTYVP 89