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Conserved domains on  [gi|21264363|ref|NP_006601|]
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mannan-binding lectin serine protease 2 isoform 1 preproprotein [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tryp_SPc cd00190
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ...
 445-682 1.13e-79

Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.


:

Pssm-ID: 238113 [Multi-domain]  Cd Length: 232  Bit Score: 252.97  E-value: 1.13e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 445 IYGGQKAKPGDFPWQVLI---LGGTTAAGALLYDNWVLTAAHAVYEQkhDASALDIRMGTLKRLSPHYTQ--AWSEAVFI 519
Cdd:cd00190   1 IVGGSEAKIGSFPWQVSLqytGGRHFCGGSLISPRWVLTAAHCVYSS--APSNYTVRLGSHDLSSNEGGGqvIKVKKVIV 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 520 HEGYtHDAGFDNDIALIKLNNKVVINSNITPICLPRKEAEsfMRTDDIGTASGWGLTQ-RGFLARNLMYVDIPIVDHQKC 598
Cdd:cd00190  79 HPNY-NPSTYDNDIALLKLKRPVTLSDNVRPICLPSSGYN--LPAGTTCTVSGWGRTSeGGPLPDVLQEVNVPIVSNAEC 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 599 TAAYEKPPYprgsVTANMLCAGLESGGKDSCRGDSGGALVFLDseTERWFVGGIVSWGSmNCGEAGQYGVYTKVINYIPW 678
Cdd:cd00190 156 KRAYSYGGT----ITDNMLCAGGLEGGKDACQGDSGGPLVCND--NGRGVLVGIVSWGS-GCARPNYPGVYTRVSSYLDW 228


                ....
gi 21264363 679 IENI 682
Cdd:cd00190 229 IQKT 232
CUB pfam00431
CUB domain;
184-293 1.45e-31

CUB domain;


:

Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 118.55  E-value: 1.45e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363   184 CSGqVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFvESFDVETHPEtlCPYDFLKIQTDREE----HGPFC 259
Cdd:pfam00431   1 CGG-VLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTF-QDFELEDHDE--CGYDYVEIRDGPSAssplLGRFC 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 21264363   260 GKTLPHRIETKSNTVTITFVTDESGDHTGWKIHY 293
Cdd:pfam00431  77 GSGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 28-134 1.40e-27

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


:

Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 107.09  E-value: 1.40e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363     28 GRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSG----AKVLATLCGQEstdteraPGK 103
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGpsasSPLLGRFCGSE-------APP 73

                           90       100       110
                   ....*....|....*....|....*....|.
gi 21264363    104 DTFYSLGSSLDITFRSDYSNEKpfTGFEAFY 134
Cdd:smart00042  74 PVISSSSNSLTLTFVSDSSVQK--RGFSARY 102
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 300-361 7.30e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


:

Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 55.23  E-value: 7.30e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21264363    300 CPYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQghlplkSFTAVCQKDGSWDRPMPAC 361
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIG------SSTITCLENGTWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
366-430 3.52e-07

Sushi repeat (SCR repeat);


:

Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 47.49  E-value: 3.52e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21264363   366 CGPPDDLPSGRVEYITGPgvTTYKAVIQYSCEETFYTMKVNdgKYVCEADGFWTSSKgekslPVC 430
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNE--YNYGASVSYECDPGYRLVGSP--TITCQEDGTWSPPF-----PEC 56
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 152-180 2.90e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 44.16  E-value: 2.90e-06
                          10        20
                  ....*....|....*....|....*....
gi 21264363   152 CDHHCHNHLGGFYCSCRAGYVLHRNKRTC 180
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
 
Name Accession Description Interval E-value
Tryp_SPc cd00190
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ...
 445-682 1.13e-79

Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.


Pssm-ID: 238113 [Multi-domain]  Cd Length: 232  Bit Score: 252.97  E-value: 1.13e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 445 IYGGQKAKPGDFPWQVLI---LGGTTAAGALLYDNWVLTAAHAVYEQkhDASALDIRMGTLKRLSPHYTQ--AWSEAVFI 519
Cdd:cd00190   1 IVGGSEAKIGSFPWQVSLqytGGRHFCGGSLISPRWVLTAAHCVYSS--APSNYTVRLGSHDLSSNEGGGqvIKVKKVIV 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 520 HEGYtHDAGFDNDIALIKLNNKVVINSNITPICLPRKEAEsfMRTDDIGTASGWGLTQ-RGFLARNLMYVDIPIVDHQKC 598
Cdd:cd00190  79 HPNY-NPSTYDNDIALLKLKRPVTLSDNVRPICLPSSGYN--LPAGTTCTVSGWGRTSeGGPLPDVLQEVNVPIVSNAEC 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 599 TAAYEKPPYprgsVTANMLCAGLESGGKDSCRGDSGGALVFLDseTERWFVGGIVSWGSmNCGEAGQYGVYTKVINYIPW 678
Cdd:cd00190 156 KRAYSYGGT----ITDNMLCAGGLEGGKDACQGDSGGPLVCND--NGRGVLVGIVSWGS-GCARPNYPGVYTRVSSYLDW 228


                ....
gi 21264363 679 IENI 682
Cdd:cd00190 229 IQKT 232
Tryp_SPc smart00020
Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens ...
 444-679 9.87e-79

Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. A few, however, are active as single chain molecules, and others are inactive due to substitutions of the catalytic triad residues.


Pssm-ID: 214473  Cd Length: 229  Bit Score: 250.67  E-value: 9.87e-79
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363    444 RIYGGQKAKPGDFPWQVLIL---GGTTAAGALLYDNWVLTAAHAVYeqKHDASALDIRMGTLKRLSPHYTQAWS-EAVFI 519
Cdd:smart00020   1 RIVGGSEANIGSFPWQVSLQyggGRHFCGGSLISPRWVLTAAHCVR--GSDPSNIRVRLGSHDLSSGEEGQVIKvSKVII 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363    520 HEGYtHDAGFDNDIALIKLNNKVVINSNITPICLPRKEaeSFMRTDDIGTASGWGLTQ--RGFLARNLMYVDIPIVDHQK 597
Cdd:smart00020  79 HPNY-NPSTYDNDIALLKLKEPVTLSDNVRPICLPSSN--YNVPAGTTCTVSGWGRTSegAGSLPDTLQEVNVPIVSNAT 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363    598 CTAAYekppYPRGSVTANMLCAGLESGGKDSCRGDSGGALVFLDsetERWFVGGIVSWGSmNCGEAGQYGVYTKVINYIP 677
Cdd:smart00020 156 CRRAY----SGGGAITDNMLCAGGLEGGKDACQGDSGGPLVCND---GRWVLVGIVSWGS-GCARPGKPGVYTRVSSYLD 227


                   ..
gi 21264363    678 WI 679
Cdd:smart00020 228 WI 229
Trypsin pfam00089
Trypsin;
445-679 4.25e-55

Trypsin;


Pssm-ID: 459667 [Multi-domain]  Cd Length: 219  Bit Score: 187.65  E-value: 4.25e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363   445 IYGGQKAKPGDFPWQVLIL---GGTTAAGALLYDNWVLTAAHAVYeqkhDASALDIRMG--TLKRLSPHYTQAWSEAVFI 519
Cdd:pfam00089   1 IVGGDEAQPGSFPWQVSLQlssGKHFCGGSLISENWVLTAAHCVS----GASDVKVVLGahNIVLREGGEQKFDVEKIIV 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363   520 HEGYTHDaGFDNDIALIKLNNKVVINSNITPICLPRKEAESFMRTddIGTASGWGLTQRGFLARNLMYVDIPIVDHQKCT 599
Cdd:pfam00089  77 HPNYNPD-TLDNDIALLKLESPVTLGDTVRPICLPDASSDLPVGT--TCTVSGWGNTKTLGPSDTLQEVTVPVVSRETCR 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363   600 AAYekppypRGSVTANMLCAGleSGGKDSCRGDSGGALVFLDSEterwfVGGIVSWGSmNCGEAGQYGVYTKVINYIPWI 679
Cdd:pfam00089 154 SAY------GGTVTDTMICAG--AGGKDACQGDSGGPLVCSDGE-----LIGIVSWGY-GCASGNYPGVYTPVSSYLDWI 219
COG5640 COG5640
Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, ...
 432-683 3.40e-54

Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444365 [Multi-domain]  Cd Length: 262  Bit Score: 186.78  E-value: 3.40e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 432 PVCGLSARTTGGRIYGGQKAKPGDFPWQVLIL--GGTTAA---GALLYDNWVLTAAHAVYEQkhDASALDIRMGTLKRLS 506
Cdd:COG5640  18 ALAAAPAADAAPAIVGGTPATVGEYPWMVALQssNGPSGQfcgGTLIAPRWVLTAAHCVDGD--GPSDLRVVIGSTDLST 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 507 PHYTQAWSEAVFIHEGYThDAGFDNDIALIKLNNKVvinSNITPICLPrkEAESFMRTDDIGTASGWGLT--QRGFLARN 584
Cdd:COG5640  96 SGGTVVKVARIVVHPDYD-PATPGNDIALLKLATPV---PGVAPAPLA--TSADAAAPGTPATVAGWGRTseGPGSQSGT 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 585 LMYVDIPIVDHQKCTAayekppyPRGSVTANMLCAGLESGGKDSCRGDSGGALVFLDSetERWFVGGIVSWGSMNCGeAG 664
Cdd:COG5640 170 LRKADVPVVSDATCAA-------YGGFDGGTMLCAGYPEGGKDACQGDSGGPLVVKDG--GGWVLVGVVSWGGGPCA-AG 239

                       250
                ....*....|....*....
gi 21264363 665 QYGVYTKVINYIPWIENII 683
Cdd:COG5640 240 YPGVYTRVSAYRDWIKSTA 258
CUB pfam00431
CUB domain;
184-293 1.45e-31

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 118.55  E-value: 1.45e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363   184 CSGqVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFvESFDVETHPEtlCPYDFLKIQTDREE----HGPFC 259
Cdd:pfam00431   1 CGG-VLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTF-QDFELEDHDE--CGYDYVEIRDGPSAssplLGRFC 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 21264363   260 GKTLPHRIETKSNTVTITFVTDESGDHTGWKIHY 293
Cdd:pfam00431  77 GSGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 184-295 2.55e-31

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 117.90  E-value: 2.55e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 184 CSGQVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFvESFDVETHPEtlCPYDFLKI----QTDREEHGPFC 259
Cdd:cd00041   1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTF-EDFDLESSPN--CSYDYLEIydgpSTSSPLLGRFC 77

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 21264363 260 GKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTS 295
Cdd:cd00041  78 GSTLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 194-293 1.38e-27

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 107.09  E-value: 1.38e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363    194 GELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFvESFDVETHPEtlCPYDFLKIQ----TDREEHGPFCGKTLPHR-IE 268
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQF-TDFDLESSDN--CEYDYVEIYdgpsASSPLLGRFCGSEAPPPvIS 77

                           90       100
                   ....*....|....*....|....*
gi 21264363    269 TKSNTVTITFVTDESGDHTGWKIHY 293
Cdd:smart00042  78 SSSNSLTLTFVSDSSVQKRGFSARY 102
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 28-134 1.40e-27

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 107.09  E-value: 1.40e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363     28 GRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSG----AKVLATLCGQEstdteraPGK 103
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGpsasSPLLGRFCGSE-------APP 73

                           90       100       110
                   ....*....|....*....|....*....|.
gi 21264363    104 DTFYSLGSSLDITFRSDYSNEKpfTGFEAFY 134
Cdd:smart00042  74 PVISSSSNSLTLTFVSDSSVQK--RGFSARY 102
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 11-136 6.11e-27

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 105.57  E-value: 6.11e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363  11 CGSVATplgpkwpEPVFGRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSG----AKVL 86
Cdd:cd00041   1 CGGTLT-------ASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGpstsSPLL 73

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 21264363  87 ATLCGQEStdterapgKDTFYSLGSSLDITFRSDYSNEKpfTGFEAFYAA 136
Cdd:cd00041  74 GRFCGSTL--------PPPIISSGNSLTVRFRSDSSVTG--RGFKATYSA 113
CUB pfam00431
CUB domain;
11-134 7.87e-17

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 76.56  E-value: 7.87e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363    11 CGSVATPLgpkwpepvFGRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSG----AKVL 86
Cdd:pfam00431   1 CGGVLTDS--------SGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGpsasSPLL 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 21264363    87 ATLCGQEstdterAPgkDTFYSLGSSLDITFRSDYSNEKpfTGFEAFY 134
Cdd:pfam00431  73 GRFCGSG------IP--EDIVSSSNQMTIKFVSDASVQK--RGFKATY 110
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 300-361 7.30e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 55.23  E-value: 7.30e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21264363    300 CPYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQghlplkSFTAVCQKDGSWDRPMPAC 361
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIG------SSTITCLENGTWSPPPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 300-361 1.98e-09

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 54.01  E-value: 1.98e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21264363 300 CPYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQghlplkSFTAVCQKDGSWDRPMPAC 361
Cdd:cd00033   1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVG------SSTITCTENGGWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
300-361 3.74e-09

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 52.89  E-value: 3.74e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21264363   300 CPYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELlQGhlplkSFTAVCQKDGSWDRPMPAC 361
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRL-VG-----SPTITCQEDGTWSPPFPEC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
366-430 3.52e-07

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 47.49  E-value: 3.52e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21264363   366 CGPPDDLPSGRVEYITGPgvTTYKAVIQYSCEETFYTMKVNdgKYVCEADGFWTSSKgekslPVC 430
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNE--YNYGASVSYECDPGYRLVGSP--TITCQEDGTWSPPF-----PEC 56
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 152-180 2.90e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 44.16  E-value: 2.90e-06
                          10        20
                  ....*....|....*....|....*....
gi 21264363   152 CDHHCHNHLGGFYCSCRAGYVLHRNKRTC 180
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
138-176 3.36e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 3.36e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 21264363    138 DIDECQvapgEAPTCDHH--CHNHLGGFYCSCRAGYVLHRN 176
Cdd:smart00179   1 DIDECA----SGNPCQNGgtCVNTVGSYRCECPPGYTDGRN 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 138-175 9.83e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 9.83e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 21264363 138 DIDECQvapgEAPTCDHH--CHNHLGGFYCSCRAGYVLHR 175
Cdd:cd00054   1 DIDECA----SGNPCQNGgtCVNTVGSYRCSCPPGYTGRN 36
PHA02817 PHA02817
EEV Host range protein; Provisional
 300-430 1.22e-04

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 44.16  E-value: 1.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363  300 CPYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQGHLpLKSFTAVCQKDGSWDRPMPACSIVDCGPPdDLPSGRVEY 379
Cdd:PHA02817  24 CCYPPSIKNGYIYNKKTEYNIGSNVTFFCGNNTRGVRYTL-VGEKNIICEKDGKWNKEFPVCKIIRCRFP-ALQNGFVNG 101

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 21264363  380 ITGPGVTTYKAVIQYSCEETFytMKVNDGKYVCEADGFWTSskgekSLPVC 430
Cdd:PHA02817 102 IPDSKKFYYESEVSFSCKPGF--VLIGTKYSVCGINSSWIP-----KVPIC 145
 
Name Accession Description Interval E-value
Tryp_SPc cd00190
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ...
 445-682 1.13e-79

Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.


Pssm-ID: 238113 [Multi-domain]  Cd Length: 232  Bit Score: 252.97  E-value: 1.13e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 445 IYGGQKAKPGDFPWQVLI---LGGTTAAGALLYDNWVLTAAHAVYEQkhDASALDIRMGTLKRLSPHYTQ--AWSEAVFI 519
Cdd:cd00190   1 IVGGSEAKIGSFPWQVSLqytGGRHFCGGSLISPRWVLTAAHCVYSS--APSNYTVRLGSHDLSSNEGGGqvIKVKKVIV 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 520 HEGYtHDAGFDNDIALIKLNNKVVINSNITPICLPRKEAEsfMRTDDIGTASGWGLTQ-RGFLARNLMYVDIPIVDHQKC 598
Cdd:cd00190  79 HPNY-NPSTYDNDIALLKLKRPVTLSDNVRPICLPSSGYN--LPAGTTCTVSGWGRTSeGGPLPDVLQEVNVPIVSNAEC 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 599 TAAYEKPPYprgsVTANMLCAGLESGGKDSCRGDSGGALVFLDseTERWFVGGIVSWGSmNCGEAGQYGVYTKVINYIPW 678
Cdd:cd00190 156 KRAYSYGGT----ITDNMLCAGGLEGGKDACQGDSGGPLVCND--NGRGVLVGIVSWGS-GCARPNYPGVYTRVSSYLDW 228


                ....
gi 21264363 679 IENI 682
Cdd:cd00190 229 IQKT 232
Tryp_SPc smart00020
Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens ...
 444-679 9.87e-79

Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. A few, however, are active as single chain molecules, and others are inactive due to substitutions of the catalytic triad residues.


Pssm-ID: 214473  Cd Length: 229  Bit Score: 250.67  E-value: 9.87e-79
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363    444 RIYGGQKAKPGDFPWQVLIL---GGTTAAGALLYDNWVLTAAHAVYeqKHDASALDIRMGTLKRLSPHYTQAWS-EAVFI 519
Cdd:smart00020   1 RIVGGSEANIGSFPWQVSLQyggGRHFCGGSLISPRWVLTAAHCVR--GSDPSNIRVRLGSHDLSSGEEGQVIKvSKVII 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363    520 HEGYtHDAGFDNDIALIKLNNKVVINSNITPICLPRKEaeSFMRTDDIGTASGWGLTQ--RGFLARNLMYVDIPIVDHQK 597
Cdd:smart00020  79 HPNY-NPSTYDNDIALLKLKEPVTLSDNVRPICLPSSN--YNVPAGTTCTVSGWGRTSegAGSLPDTLQEVNVPIVSNAT 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363    598 CTAAYekppYPRGSVTANMLCAGLESGGKDSCRGDSGGALVFLDsetERWFVGGIVSWGSmNCGEAGQYGVYTKVINYIP 677
Cdd:smart00020 156 CRRAY----SGGGAITDNMLCAGGLEGGKDACQGDSGGPLVCND---GRWVLVGIVSWGS-GCARPGKPGVYTRVSSYLD 227


                   ..
gi 21264363    678 WI 679
Cdd:smart00020 228 WI 229
Trypsin pfam00089
Trypsin;
445-679 4.25e-55

Trypsin;


Pssm-ID: 459667 [Multi-domain]  Cd Length: 219  Bit Score: 187.65  E-value: 4.25e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363   445 IYGGQKAKPGDFPWQVLIL---GGTTAAGALLYDNWVLTAAHAVYeqkhDASALDIRMG--TLKRLSPHYTQAWSEAVFI 519
Cdd:pfam00089   1 IVGGDEAQPGSFPWQVSLQlssGKHFCGGSLISENWVLTAAHCVS----GASDVKVVLGahNIVLREGGEQKFDVEKIIV 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363   520 HEGYTHDaGFDNDIALIKLNNKVVINSNITPICLPRKEAESFMRTddIGTASGWGLTQRGFLARNLMYVDIPIVDHQKCT 599
Cdd:pfam00089  77 HPNYNPD-TLDNDIALLKLESPVTLGDTVRPICLPDASSDLPVGT--TCTVSGWGNTKTLGPSDTLQEVTVPVVSRETCR 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363   600 AAYekppypRGSVTANMLCAGleSGGKDSCRGDSGGALVFLDSEterwfVGGIVSWGSmNCGEAGQYGVYTKVINYIPWI 679
Cdd:pfam00089 154 SAY------GGTVTDTMICAG--AGGKDACQGDSGGPLVCSDGE-----LIGIVSWGY-GCASGNYPGVYTPVSSYLDWI 219
COG5640 COG5640
Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, ...
 432-683 3.40e-54

Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444365 [Multi-domain]  Cd Length: 262  Bit Score: 186.78  E-value: 3.40e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 432 PVCGLSARTTGGRIYGGQKAKPGDFPWQVLIL--GGTTAA---GALLYDNWVLTAAHAVYEQkhDASALDIRMGTLKRLS 506
Cdd:COG5640  18 ALAAAPAADAAPAIVGGTPATVGEYPWMVALQssNGPSGQfcgGTLIAPRWVLTAAHCVDGD--GPSDLRVVIGSTDLST 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 507 PHYTQAWSEAVFIHEGYThDAGFDNDIALIKLNNKVvinSNITPICLPrkEAESFMRTDDIGTASGWGLT--QRGFLARN 584
Cdd:COG5640  96 SGGTVVKVARIVVHPDYD-PATPGNDIALLKLATPV---PGVAPAPLA--TSADAAAPGTPATVAGWGRTseGPGSQSGT 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 585 LMYVDIPIVDHQKCTAayekppyPRGSVTANMLCAGLESGGKDSCRGDSGGALVFLDSetERWFVGGIVSWGSMNCGeAG 664
Cdd:COG5640 170 LRKADVPVVSDATCAA-------YGGFDGGTMLCAGYPEGGKDACQGDSGGPLVVKDG--GGWVLVGVVSWGGGPCA-AG 239

                       250
                ....*....|....*....
gi 21264363 665 QYGVYTKVINYIPWIENII 683
Cdd:COG5640 240 YPGVYTRVSAYRDWIKSTA 258
CUB pfam00431
CUB domain;
184-293 1.45e-31

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 118.55  E-value: 1.45e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363   184 CSGqVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFvESFDVETHPEtlCPYDFLKIQTDREE----HGPFC 259
Cdd:pfam00431   1 CGG-VLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTF-QDFELEDHDE--CGYDYVEIRDGPSAssplLGRFC 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 21264363   260 GKTLPHRIETKSNTVTITFVTDESGDHTGWKIHY 293
Cdd:pfam00431  77 GSGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 184-295 2.55e-31

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 117.90  E-value: 2.55e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 184 CSGQVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFvESFDVETHPEtlCPYDFLKI----QTDREEHGPFC 259
Cdd:cd00041   1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTF-EDFDLESSPN--CSYDYLEIydgpSTSSPLLGRFC 77

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 21264363 260 GKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTS 295
Cdd:cd00041  78 GSTLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 194-293 1.38e-27

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 107.09  E-value: 1.38e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363    194 GELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFvESFDVETHPEtlCPYDFLKIQ----TDREEHGPFCGKTLPHR-IE 268
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQF-TDFDLESSDN--CEYDYVEIYdgpsASSPLLGRFCGSEAPPPvIS 77

                           90       100
                   ....*....|....*....|....*
gi 21264363    269 TKSNTVTITFVTDESGDHTGWKIHY 293
Cdd:smart00042  78 SSSNSLTLTFVSDSSVQKRGFSARY 102
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 28-134 1.40e-27

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 107.09  E-value: 1.40e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363     28 GRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSG----AKVLATLCGQEstdteraPGK 103
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGpsasSPLLGRFCGSE-------APP 73

                           90       100       110
                   ....*....|....*....|....*....|.
gi 21264363    104 DTFYSLGSSLDITFRSDYSNEKpfTGFEAFY 134
Cdd:smart00042  74 PVISSSSNSLTLTFVSDSSVQK--RGFSARY 102
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 11-136 6.11e-27

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 105.57  E-value: 6.11e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363  11 CGSVATplgpkwpEPVFGRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSG----AKVL 86
Cdd:cd00041   1 CGGTLT-------ASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGpstsSPLL 73

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 21264363  87 ATLCGQEStdterapgKDTFYSLGSSLDITFRSDYSNEKpfTGFEAFYAA 136
Cdd:cd00041  74 GRFCGSTL--------PPPIISSGNSLTVRFRSDSSVTG--RGFKATYSA 113
CUB pfam00431
CUB domain;
11-134 7.87e-17

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 76.56  E-value: 7.87e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363    11 CGSVATPLgpkwpepvFGRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSG----AKVL 86
Cdd:pfam00431   1 CGGVLTDS--------SGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGpsasSPLL 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 21264363    87 ATLCGQEstdterAPgkDTFYSLGSSLDITFRSDYSNEKpfTGFEAFY 134
Cdd:pfam00431  73 GRFCGSG------IP--EDIVSSSNQMTIKFVSDASVQK--RGFKATY 110
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 300-361 7.30e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 55.23  E-value: 7.30e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21264363    300 CPYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQghlplkSFTAVCQKDGSWDRPMPAC 361
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIG------SSTITCLENGTWSPPPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 300-361 1.98e-09

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 54.01  E-value: 1.98e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21264363 300 CPYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQghlplkSFTAVCQKDGSWDRPMPAC 361
Cdd:cd00033   1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVG------SSTITCTENGGWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
300-361 3.74e-09

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 52.89  E-value: 3.74e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21264363   300 CPYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELlQGhlplkSFTAVCQKDGSWDRPMPAC 361
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRL-VG-----SPTITCQEDGTWSPPFPEC 56
eMpr COG3591
V8-like Glu-specific endopeptidase [Posttranslational modification, protein turnover, ...
 470-666 9.02e-08

V8-like Glu-specific endopeptidase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442810 [Multi-domain]  Cd Length: 194  Bit Score: 52.76  E-value: 9.02e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 470 GALLYDNWVLTAAHAVYEQKHDASALDIRMGTLKRLSPhYTQAWSEAVFIHEGYTHDAGFDNDIALIKLNNKVvinSNIT 549
Cdd:COG3591  16 GTLIGPNLVLTAGHCVYDGAGGGWATNIVFVPGYNGGP-YGTATATRFRVPPGWVASGDAGYDYALLRLDEPL---GDTT 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 550 PiCLPRKEAESFMRTDDIgTASGWGLTQRGFLArnlMYVDIPIVDHQKCTAAYEkppyprgsvtanmlCaglesggkDSC 629
Cdd:COG3591  92 G-WLGLAFNDAPLAGEPV-TIIGYPGDRPKDLS---LDCSGRVTGVQGNRLSYD--------------C--------DTT 144

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 21264363 630 RGDSGGALvfLDSETERWFVGGIVSWGSMNCGEAGQY 666
Cdd:COG3591 145 GGSSGSPV--LDDSDGGGRVVGVHSAGGADRANTGVR 179
Sushi pfam00084
Sushi repeat (SCR repeat);
366-430 3.52e-07

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 47.49  E-value: 3.52e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21264363   366 CGPPDDLPSGRVEYITGPgvTTYKAVIQYSCEETFYTMKVNdgKYVCEADGFWTSSKgekslPVC 430
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNE--YNYGASVSYECDPGYRLVGSP--TITCQEDGTWSPPF-----PEC 56
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 152-180 2.90e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 44.16  E-value: 2.90e-06
                          10        20
                  ....*....|....*....|....*....
gi 21264363   152 CDHHCHNHLGGFYCSCRAGYVLHRNKRTC 180
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
138-176 3.36e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 3.36e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 21264363    138 DIDECQvapgEAPTCDHH--CHNHLGGFYCSCRAGYVLHRN 176
Cdd:smart00179   1 DIDECA----SGNPCQNGgtCVNTVGSYRCECPPGYTDGRN 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 138-175 9.83e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 9.83e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 21264363 138 DIDECQvapgEAPTCDHH--CHNHLGGFYCSCRAGYVLHR 175
Cdd:cd00054   1 DIDECA----SGNPCQNGgtCVNTVGSYRCSCPPGYTGRN 36
PHA02817 PHA02817
EEV Host range protein; Provisional
 300-430 1.22e-04

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 44.16  E-value: 1.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363  300 CPYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQGHLpLKSFTAVCQKDGSWDRPMPACSIVDCGPPdDLPSGRVEY 379
Cdd:PHA02817  24 CCYPPSIKNGYIYNKKTEYNIGSNVTFFCGNNTRGVRYTL-VGEKNIICEKDGKWNKEFPVCKIIRCRFP-ALQNGFVNG 101

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 21264363  380 ITGPGVTTYKAVIQYSCEETFytMKVNDGKYVCEADGFWTSskgekSLPVC 430
Cdd:PHA02817 102 IPDSKKFYYESEVSFSCKPGF--VLIGTKYSVCGINSSWIP-----KVPIC 145
EGF_CA pfam07645
Calcium-binding EGF domain;
138-170 1.13e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.83  E-value: 1.13e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 21264363   138 DIDECQvapGEAPTCDH--HCHNHLGGFYCSCRAG 170
Cdd:pfam07645   1 DVDECA---TGTHNCPAntVCVNTIGSFECRCPDG 32
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 287-433 9.84e-03

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 38.48  E-value: 9.84e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363  287 TGWKIHYTSTAQPCPYPMAPPNGHVSPVQAKYilKDSFSIFCETGYELLQGHlplKSFTAVcQKDGS--WDRPMPACSIV 364
Cdd:PHA02927  73 TGWTLFNQCIKRRCPSPRDIDNGQLDIGGVDF--GSSITYSCNSGYQLIGES---KSYCEL-GSTGSmvWNPEAPICESV 146

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21264363  365 DCGPPDDLPSGRveYITGPGVTTYKAVIQYSCeETFYTMKVNDGkYVCEAdGFWTSSkgekslPVCEPV 433
Cdd:PHA02927 147 KCQSPPSISNGR--HNGYEDFYTDGSVVTYSC-NSGYSLIGNSG-VLCSG-GEWSDP------PTCQIV 204
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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