NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|21493033|ref|NP_009133|]
View 

A-kinase anchor protein 10, mitochondrial isoform 1 precursor [Homo sapiens]

Protein Classification

regulator of G-protein signaling domain-containing protein( domain architecture ID 10171674)

regulator of G-protein signaling (RGS) domain-containing protein belongs to a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs)

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
RGS_AKAP2_1 cd08735
Regulator of G protein signaling (RGS) domain 1 found in the A-kinase anchoring protein, ...
 122-367 1.15e-90

Regulator of G protein signaling (RGS) domain 1 found in the A-kinase anchoring protein, D-AKAP2; The RGS (Regulator of G-protein Signaling) domain is an essential part of the D-AKAP2 (A-kinase anchoring protein), a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. D-AKAP2 contains two RGS domains which play an important role in spatiotemporal localization of cAMP-dependent PKA (cyclic AMP-dependent protein kinase) that regulates many different signaling pathways by phosphorylation of target proteins. This cd contains the first RGS domain.


:

Pssm-ID: 188689 [Multi-domain]  Cd Length: 171  Bit Score: 278.95  E-value: 1.15e-90
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21493033 122 LSKTLEQVLHDTIVLPYFIQFMELRRMEHLVKFWLEAESFHSTTWSRIRAHSLNTVKQSSLAEPVSPSKKHETTASFLTD 201
Cdd:cd08735   1 LSKTLEQILHDNSALPYFIQFMETRRAEHLIKFWLEAESFKSAAWSRIRAHSLNTVKHSSLEEPVSPSLDRKVLESKSTD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21493033 202 SLDKRLEDSGSAQLfmthsegidlnnrtnstqnhlllsqecdsahslrlemaragthqvsmetqessstltvasrnspas 281
Cdd:cd08735  81 SLSQRLTDDDDEKS------------------------------------------------------------------ 94

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21493033 282 plkelsgklMKSIEQDAVNTFTKYISPDAAKPIPITEAMRNDIIARICGEDGQVDPNCFVLAQSIVFSAMEQEHFSEFLR 361
Cdd:cd08735  95 ---------MKSIERDAVSIYTKYISPDAAKPIPITEEIRNDIVAKICGEDGQVDPNCFVEAQSFVFSAMEQDHFTEFLR 165


                ....*.
gi 21493033 362 SHHFCK 367
Cdd:cd08735 166 SHFFCK 171
RGS_AKAP2_2 cd08721
Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, ...
 383-503 4.56e-75

Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, D-AKAP2; The RGS (Regulator of G-protein Signaling) domain is an essential part of the D-AKAP2 (A-kinase anchoring protein), a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. D-AKAP2 contains two RGS domains which play an important role in spatiotemporal localization of cAMP-dependent PKA (cyclic AMP-dependent protein kinase) that regulates many different signaling pathways by phosphorylation of target proteins. This cd contains the second RGS domain.


:

Pssm-ID: 188676  Cd Length: 121  Bit Score: 236.47  E-value: 4.56e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21493033 383 ILFCESALFYFSEYMEKEDAVNILQFWLAADNFQSQLAAKKGQYDGQEAQNDAMILYDKYFSLQATHPLGFDDVVRLEIE 462
Cdd:cd08721   1 ILYCESALFYFMEYMEQEGARNLLQFWLAADNFQSQLAAKEGQYDGQQAQNDAMIIYDKYFSLQATEPLGFDDKTRLEVE 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 21493033 463 SNICREGGPLPNCFTTPLRQAWTTMEKVFLPGFLSSNLYYK 503
Cdd:cd08721  81 SNICREGGPLPSCFEAPLLQALTTLEQHYLPGFLSSQLYYK 121
AKAP10_AKB cd12804
PKA-binding (AKB) domain of A Kinase Anchor Protein 10; AKAPs coordinate the specificity of ...
 618-662 2.78e-16

PKA-binding (AKB) domain of A Kinase Anchor Protein 10; AKAPs coordinate the specificity of PKA signaling by facilitating the localization of the kinase to subcellular sites through their binding to regulatory (R) subunits of PKA. AKAP-10, also called PRKA10 or Dual-specific AKAP 2 (D-AKAP2), is a multisubunit protein containing two regulator of G protein signaling (RGS)-like domains and a PKA-binding (AKB) domain. The AKB domain of AKAP10 can bind to the dimerization/docking (D/D) domains of both RI and RII regulatory subunits of PKA. This model also includes a C-terminal PDZ-binding motif that binds to PDZK1 and NHERF-1, allowing AKAP10 to link indirectly to membrane proteins. Mutations in AKAP10 can alter its binding to R subunits, which may alter the targeting of PKA; some AKAP10 mutations are associated with abnormalities including hypertension, increased risk of severe arrhythmias during kidney transplantation, and familial breast cancer.


:

Pssm-ID: 214003  Cd Length: 45  Bit Score: 72.85  E-value: 2.78e-16
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 21493033 618 AMKKWVQGNTDEAQEELAWKIAKMIVSDIMQQAQYDQPLEKSTKL 662
Cdd:cd12804   1 AFKKWVQPEPDEAKEEMAWKIAKMIVNDVEDQAQEEMAWQVAEMI 45
 
Name Accession Description Interval E-value
RGS_AKAP2_1 cd08735
Regulator of G protein signaling (RGS) domain 1 found in the A-kinase anchoring protein, ...
 122-367 1.15e-90

Regulator of G protein signaling (RGS) domain 1 found in the A-kinase anchoring protein, D-AKAP2; The RGS (Regulator of G-protein Signaling) domain is an essential part of the D-AKAP2 (A-kinase anchoring protein), a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. D-AKAP2 contains two RGS domains which play an important role in spatiotemporal localization of cAMP-dependent PKA (cyclic AMP-dependent protein kinase) that regulates many different signaling pathways by phosphorylation of target proteins. This cd contains the first RGS domain.


Pssm-ID: 188689 [Multi-domain]  Cd Length: 171  Bit Score: 278.95  E-value: 1.15e-90
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21493033 122 LSKTLEQVLHDTIVLPYFIQFMELRRMEHLVKFWLEAESFHSTTWSRIRAHSLNTVKQSSLAEPVSPSKKHETTASFLTD 201
Cdd:cd08735   1 LSKTLEQILHDNSALPYFIQFMETRRAEHLIKFWLEAESFKSAAWSRIRAHSLNTVKHSSLEEPVSPSLDRKVLESKSTD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21493033 202 SLDKRLEDSGSAQLfmthsegidlnnrtnstqnhlllsqecdsahslrlemaragthqvsmetqessstltvasrnspas 281
Cdd:cd08735  81 SLSQRLTDDDDEKS------------------------------------------------------------------ 94

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21493033 282 plkelsgklMKSIEQDAVNTFTKYISPDAAKPIPITEAMRNDIIARICGEDGQVDPNCFVLAQSIVFSAMEQEHFSEFLR 361
Cdd:cd08735  95 ---------MKSIERDAVSIYTKYISPDAAKPIPITEEIRNDIVAKICGEDGQVDPNCFVEAQSFVFSAMEQDHFTEFLR 165


                ....*.
gi 21493033 362 SHHFCK 367
Cdd:cd08735 166 SHFFCK 171
RGS_AKAP2_2 cd08721
Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, ...
 383-503 4.56e-75

Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, D-AKAP2; The RGS (Regulator of G-protein Signaling) domain is an essential part of the D-AKAP2 (A-kinase anchoring protein), a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. D-AKAP2 contains two RGS domains which play an important role in spatiotemporal localization of cAMP-dependent PKA (cyclic AMP-dependent protein kinase) that regulates many different signaling pathways by phosphorylation of target proteins. This cd contains the second RGS domain.


Pssm-ID: 188676  Cd Length: 121  Bit Score: 236.47  E-value: 4.56e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21493033 383 ILFCESALFYFSEYMEKEDAVNILQFWLAADNFQSQLAAKKGQYDGQEAQNDAMILYDKYFSLQATHPLGFDDVVRLEIE 462
Cdd:cd08721   1 ILYCESALFYFMEYMEQEGARNLLQFWLAADNFQSQLAAKEGQYDGQQAQNDAMIIYDKYFSLQATEPLGFDDKTRLEVE 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 21493033 463 SNICREGGPLPNCFTTPLRQAWTTMEKVFLPGFLSSNLYYK 503
Cdd:cd08721  81 SNICREGGPLPSCFEAPLLQALTTLEQHYLPGFLSSQLYYK 121
RGS smart00315
Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins ...
 380-504 1.45e-24

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 214613  Cd Length: 118  Bit Score: 98.88  E-value: 1.45e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21493033    380 LADILFCESALFYFSEYMEKEDAVNILQFWLAADNFQSqlaakkgQYDGQEAQNDAMILYDKYFSLQATHPLGFDDVVRL 459
Cdd:smart00315   2 LESLLSDPIGRLLFREFLESEFSEENLEFWLAVEEFKK-------AEDDEERIAKAREIYDKFLSPNAPKEVNLDSDLRE 74

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 21493033    460 EIESNICrEGGPLPNCFTTPLRQAWTTMEKVFLPGFLSSNLYYKY 504
Cdd:smart00315  75 KIEENLE-SEEPPPDLFDEAQREVYELLEKDSFPRFLESDYYLRF 118
AKAP10_AKB cd12804
PKA-binding (AKB) domain of A Kinase Anchor Protein 10; AKAPs coordinate the specificity of ...
 618-662 2.78e-16

PKA-binding (AKB) domain of A Kinase Anchor Protein 10; AKAPs coordinate the specificity of PKA signaling by facilitating the localization of the kinase to subcellular sites through their binding to regulatory (R) subunits of PKA. AKAP-10, also called PRKA10 or Dual-specific AKAP 2 (D-AKAP2), is a multisubunit protein containing two regulator of G protein signaling (RGS)-like domains and a PKA-binding (AKB) domain. The AKB domain of AKAP10 can bind to the dimerization/docking (D/D) domains of both RI and RII regulatory subunits of PKA. This model also includes a C-terminal PDZ-binding motif that binds to PDZK1 and NHERF-1, allowing AKAP10 to link indirectly to membrane proteins. Mutations in AKAP10 can alter its binding to R subunits, which may alter the targeting of PKA; some AKAP10 mutations are associated with abnormalities including hypertension, increased risk of severe arrhythmias during kidney transplantation, and familial breast cancer.


Pssm-ID: 214003  Cd Length: 45  Bit Score: 72.85  E-value: 2.78e-16
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 21493033 618 AMKKWVQGNTDEAQEELAWKIAKMIVSDIMQQAQYDQPLEKSTKL 662
Cdd:cd12804   1 AFKKWVQPEPDEAKEEMAWKIAKMIVNDVEDQAQEEMAWQVAEMI 45
RGS smart00315
Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins ...
 292-368 2.58e-15

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 214613  Cd Length: 118  Bit Score: 72.69  E-value: 2.58e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21493033    292 KSIEQDAVNTFTKYISPDAAKPIPITEAMRNDIIARICGEdgQVDPNCFVLAQSIVFSAMEQEHFSEFLRSHHFCKY 368
Cdd:smart00315  44 EERIAKAREIYDKFLSPNAPKEVNLDSDLREKIEENLESE--EPPPDLFDEAQREVYELLEKDSFPRFLESDYYLRF 118
RGS pfam00615
Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for ...
 380-504 1.33e-09

Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 459870  Cd Length: 117  Bit Score: 56.08  E-value: 1.33e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21493033   380 LADILFCESALFYFSEYMEKEDAVNILQFWLAADNFqsqlaakKGQYDGQEAQNDAMILYDKYFSLQATHPLGFDDVVRL 459
Cdd:pfam00615   2 FDSLLEDQPGRRLFRQFLESEFSEENLEFWLACEEF-------KKADPDEERLKKAKEIYNEFLAPGSPKEINLDSDLRE 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 21493033   460 EIESNICREggPLPNCFTTPLRQAWTTMEKVFLPGFLSSNLYYKY 504
Cdd:pfam00615  75 EIRENLEKE--PTRDLFDEAQAEVYELMEKDSYPRFLKSPLYLRL 117
RGS pfam00615
Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for ...
 289-362 1.65e-07

Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 459870  Cd Length: 117  Bit Score: 50.31  E-value: 1.65e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21493033   289 KLMKSIE---QDAVNTFTKYISPDAAKPIPITEAMRNDIIARICGEdgqVDPNCFVLAQSIVFSAMEQEHFSEFLRS 362
Cdd:pfam00615  38 KKADPDEerlKKAKEIYNEFLAPGSPKEINLDSDLREEIRENLEKE---PTRDLFDEAQAEVYELMEKDSYPRFLKS 111
 
Name Accession Description Interval E-value
RGS_AKAP2_1 cd08735
Regulator of G protein signaling (RGS) domain 1 found in the A-kinase anchoring protein, ...
 122-367 1.15e-90

Regulator of G protein signaling (RGS) domain 1 found in the A-kinase anchoring protein, D-AKAP2; The RGS (Regulator of G-protein Signaling) domain is an essential part of the D-AKAP2 (A-kinase anchoring protein), a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. D-AKAP2 contains two RGS domains which play an important role in spatiotemporal localization of cAMP-dependent PKA (cyclic AMP-dependent protein kinase) that regulates many different signaling pathways by phosphorylation of target proteins. This cd contains the first RGS domain.


Pssm-ID: 188689 [Multi-domain]  Cd Length: 171  Bit Score: 278.95  E-value: 1.15e-90
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21493033 122 LSKTLEQVLHDTIVLPYFIQFMELRRMEHLVKFWLEAESFHSTTWSRIRAHSLNTVKQSSLAEPVSPSKKHETTASFLTD 201
Cdd:cd08735   1 LSKTLEQILHDNSALPYFIQFMETRRAEHLIKFWLEAESFKSAAWSRIRAHSLNTVKHSSLEEPVSPSLDRKVLESKSTD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21493033 202 SLDKRLEDSGSAQLfmthsegidlnnrtnstqnhlllsqecdsahslrlemaragthqvsmetqessstltvasrnspas 281
Cdd:cd08735  81 SLSQRLTDDDDEKS------------------------------------------------------------------ 94

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21493033 282 plkelsgklMKSIEQDAVNTFTKYISPDAAKPIPITEAMRNDIIARICGEDGQVDPNCFVLAQSIVFSAMEQEHFSEFLR 361
Cdd:cd08735  95 ---------MKSIERDAVSIYTKYISPDAAKPIPITEEIRNDIVAKICGEDGQVDPNCFVEAQSFVFSAMEQDHFTEFLR 165


                ....*.
gi 21493033 362 SHHFCK 367
Cdd:cd08735 166 SHFFCK 171
RGS_AKAP2_2 cd08721
Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, ...
 383-503 4.56e-75

Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, D-AKAP2; The RGS (Regulator of G-protein Signaling) domain is an essential part of the D-AKAP2 (A-kinase anchoring protein), a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. D-AKAP2 contains two RGS domains which play an important role in spatiotemporal localization of cAMP-dependent PKA (cyclic AMP-dependent protein kinase) that regulates many different signaling pathways by phosphorylation of target proteins. This cd contains the second RGS domain.


Pssm-ID: 188676  Cd Length: 121  Bit Score: 236.47  E-value: 4.56e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21493033 383 ILFCESALFYFSEYMEKEDAVNILQFWLAADNFQSQLAAKKGQYDGQEAQNDAMILYDKYFSLQATHPLGFDDVVRLEIE 462
Cdd:cd08721   1 ILYCESALFYFMEYMEQEGARNLLQFWLAADNFQSQLAAKEGQYDGQQAQNDAMIIYDKYFSLQATEPLGFDDKTRLEVE 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 21493033 463 SNICREGGPLPNCFTTPLRQAWTTMEKVFLPGFLSSNLYYK 503
Cdd:cd08721  81 SNICREGGPLPSCFEAPLLQALTTLEQHYLPGFLSSQLYYK 121
RGS smart00315
Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins ...
 380-504 1.45e-24

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 214613  Cd Length: 118  Bit Score: 98.88  E-value: 1.45e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21493033    380 LADILFCESALFYFSEYMEKEDAVNILQFWLAADNFQSqlaakkgQYDGQEAQNDAMILYDKYFSLQATHPLGFDDVVRL 459
Cdd:smart00315   2 LESLLSDPIGRLLFREFLESEFSEENLEFWLAVEEFKK-------AEDDEERIAKAREIYDKFLSPNAPKEVNLDSDLRE 74

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 21493033    460 EIESNICrEGGPLPNCFTTPLRQAWTTMEKVFLPGFLSSNLYYKY 504
Cdd:smart00315  75 KIEENLE-SEEPPPDLFDEAQREVYELLEKDSFPRFLESDYYLRF 118
RGS cd07440
Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part ...
 384-503 3.68e-23

Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. While inactive, G-alpha-subunits bind GDP, which is released and replaced by GTP upon agonist activation. GTP binding leads to dissociation of the alpha-subunit and the beta-gamma-dimer, allowing them to interact with effectors molecules and propagate signaling cascades associated with cellular growth, survival, migration, and invasion. Deactivation of the G-protein signaling controlled by the RGS domain accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in the reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins are also involved in apoptosis and cell proliferation, as well as modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play important roles in neuronal signals modulation. Some RGS proteins are principal elements needed for proper vision.


Pssm-ID: 188659 [Multi-domain]  Cd Length: 113  Bit Score: 94.77  E-value: 3.68e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21493033 384 LFCESALFYFSEYMEKEDAVNILQFWLAADNFQSQLAAKKgqydgqEAQNDAMILYDKYFSLQATHPLGFDDVVRLEIES 463
Cdd:cd07440   1 LRDPYGLEYFRQFLKSEHCEENLEFWLAVEKFKKTTSSDE------ELKSKAKEIYDKYISKDAPKEINIPESIREEIEE 74

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 21493033 464 NICREgGPLPNCFTTPLRQAWTTMEKVFLPGFLSSNLYYK 503
Cdd:cd07440  75 NLEEP-YPDPDCFDEAQEHILNLLEKDSYPRFLKSDLYLK 113
RGS cd07440
Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part ...
 291-367 2.33e-18

Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. While inactive, G-alpha-subunits bind GDP, which is released and replaced by GTP upon agonist activation. GTP binding leads to dissociation of the alpha-subunit and the beta-gamma-dimer, allowing them to interact with effectors molecules and propagate signaling cascades associated with cellular growth, survival, migration, and invasion. Deactivation of the G-protein signaling controlled by the RGS domain accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in the reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins are also involved in apoptosis and cell proliferation, as well as modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play important roles in neuronal signals modulation. Some RGS proteins are principal elements needed for proper vision.


Pssm-ID: 188659 [Multi-domain]  Cd Length: 113  Bit Score: 80.90  E-value: 2.33e-18
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21493033 291 MKSIEQDAVNTFTKYISPDAAKPIPITEAMRNDIIARICGEDgqVDPNCFVLAQSIVFSAMEQEHFSEFLRSHHFCK 367
Cdd:cd07440  39 DEELKSKAKEIYDKYISKDAPKEINIPESIREEIEENLEEPY--PDPDCFDEAQEHILNLLEKDSYPRFLKSDLYLK 113
AKAP10_AKB cd12804
PKA-binding (AKB) domain of A Kinase Anchor Protein 10; AKAPs coordinate the specificity of ...
 618-662 2.78e-16

PKA-binding (AKB) domain of A Kinase Anchor Protein 10; AKAPs coordinate the specificity of PKA signaling by facilitating the localization of the kinase to subcellular sites through their binding to regulatory (R) subunits of PKA. AKAP-10, also called PRKA10 or Dual-specific AKAP 2 (D-AKAP2), is a multisubunit protein containing two regulator of G protein signaling (RGS)-like domains and a PKA-binding (AKB) domain. The AKB domain of AKAP10 can bind to the dimerization/docking (D/D) domains of both RI and RII regulatory subunits of PKA. This model also includes a C-terminal PDZ-binding motif that binds to PDZK1 and NHERF-1, allowing AKAP10 to link indirectly to membrane proteins. Mutations in AKAP10 can alter its binding to R subunits, which may alter the targeting of PKA; some AKAP10 mutations are associated with abnormalities including hypertension, increased risk of severe arrhythmias during kidney transplantation, and familial breast cancer.


Pssm-ID: 214003  Cd Length: 45  Bit Score: 72.85  E-value: 2.78e-16
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 21493033 618 AMKKWVQGNTDEAQEELAWKIAKMIVSDIMQQAQYDQPLEKSTKL 662
Cdd:cd12804   1 AFKKWVQPEPDEAKEEMAWKIAKMIVNDVEDQAQEEMAWQVAEMI 45
RGS smart00315
Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins ...
 292-368 2.58e-15

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 214613  Cd Length: 118  Bit Score: 72.69  E-value: 2.58e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21493033    292 KSIEQDAVNTFTKYISPDAAKPIPITEAMRNDIIARICGEdgQVDPNCFVLAQSIVFSAMEQEHFSEFLRSHHFCKY 368
Cdd:smart00315  44 EERIAKAREIYDKFLSPNAPKEVNLDSDLREKIEENLESE--EPPPDLFDEAQREVYELLEKDSFPRFLESDYYLRF 118
RGS_AKAP2_1 cd08735
Regulator of G protein signaling (RGS) domain 1 found in the A-kinase anchoring protein, ...
 380-503 1.28e-12

Regulator of G protein signaling (RGS) domain 1 found in the A-kinase anchoring protein, D-AKAP2; The RGS (Regulator of G-protein Signaling) domain is an essential part of the D-AKAP2 (A-kinase anchoring protein), a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. D-AKAP2 contains two RGS domains which play an important role in spatiotemporal localization of cAMP-dependent PKA (cyclic AMP-dependent protein kinase) that regulates many different signaling pathways by phosphorylation of target proteins. This cd contains the first RGS domain.


Pssm-ID: 188689 [Multi-domain]  Cd Length: 171  Bit Score: 66.32  E-value: 1.28e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21493033 380 LADILFCESALFYFSEYMEKEDAVNILQFWLAADNFQS--------------------QLAAKKGQYDGQEAQN------ 433
Cdd:cd08735   5 LEQILHDNSALPYFIQFMETRRAEHLIKFWLEAESFKSaawsrirahslntvkhssleEPVSPSLDRKVLESKStdslsq 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21493033 434 ----------------DAMILYDKYFSLQATHPLGFDDVVRLEIESNICREGGPL-PNCFTTPLRQAWTTMEKVFLPGFL 496
Cdd:cd08735  85 rltddddeksmksierDAVSIYTKYISPDAAKPIPITEEIRNDIVAKICGEDGQVdPNCFVEAQSFVFSAMEQDHFTEFL 164


                ....*..
gi 21493033 497 SSNLYYK 503
Cdd:cd08735 165 RSHFFCK 171
RGS pfam00615
Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for ...
 380-504 1.33e-09

Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 459870  Cd Length: 117  Bit Score: 56.08  E-value: 1.33e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21493033   380 LADILFCESALFYFSEYMEKEDAVNILQFWLAADNFqsqlaakKGQYDGQEAQNDAMILYDKYFSLQATHPLGFDDVVRL 459
Cdd:pfam00615   2 FDSLLEDQPGRRLFRQFLESEFSEENLEFWLACEEF-------KKADPDEERLKKAKEIYNEFLAPGSPKEINLDSDLRE 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 21493033   460 EIESNICREggPLPNCFTTPLRQAWTTMEKVFLPGFLSSNLYYKY 504
Cdd:pfam00615  75 EIRENLEKE--PTRDLFDEAQAEVYELMEKDSYPRFLKSPLYLRL 117
RGS_AKAP2_2 cd08721
Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, ...
 297-367 2.60e-08

Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, D-AKAP2; The RGS (Regulator of G-protein Signaling) domain is an essential part of the D-AKAP2 (A-kinase anchoring protein), a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. D-AKAP2 contains two RGS domains which play an important role in spatiotemporal localization of cAMP-dependent PKA (cyclic AMP-dependent protein kinase) that regulates many different signaling pathways by phosphorylation of target proteins. This cd contains the second RGS domain.


Pssm-ID: 188676  Cd Length: 121  Bit Score: 52.73  E-value: 2.60e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21493033 297 DAVNTFTKYISPDAAKPIPITEAMRNDIIARICGEDGQVdPNCFVLAQSIVFSAMEQEHFSEFLRSHHFCK 367
Cdd:cd08721  52 DAMIIYDKYFSLQATEPLGFDDKTRLEVESNICREGGPL-PSCFEAPLLQALTTLEQHYLPGFLSSQLYYK 121
AKAP10_AKB cd12804
PKA-binding (AKB) domain of A Kinase Anchor Protein 10; AKAPs coordinate the specificity of ...
 597-642 3.95e-08

PKA-binding (AKB) domain of A Kinase Anchor Protein 10; AKAPs coordinate the specificity of PKA signaling by facilitating the localization of the kinase to subcellular sites through their binding to regulatory (R) subunits of PKA. AKAP-10, also called PRKA10 or Dual-specific AKAP 2 (D-AKAP2), is a multisubunit protein containing two regulator of G protein signaling (RGS)-like domains and a PKA-binding (AKB) domain. The AKB domain of AKAP10 can bind to the dimerization/docking (D/D) domains of both RI and RII regulatory subunits of PKA. This model also includes a C-terminal PDZ-binding motif that binds to PDZK1 and NHERF-1, allowing AKAP10 to link indirectly to membrane proteins. Mutations in AKAP10 can alter its binding to R subunits, which may alter the targeting of PKA; some AKAP10 mutations are associated with abnormalities including hypertension, increased risk of severe arrhythmias during kidney transplantation, and familial breast cancer.


Pssm-ID: 214003  Cd Length: 45  Bit Score: 49.74  E-value: 3.95e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 21493033 597 FIRESEPEPDvrKSKGSMFSQAMKKWVQGNTDEAQEELAWKIAKMI 642
Cdd:cd12804   2 FKKWVQPEPD--EAKEEMAWKIAKMIVNDVEDQAQEEMAWQVAEMI 45
RGS pfam00615
Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for ...
 289-362 1.65e-07

Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 459870  Cd Length: 117  Bit Score: 50.31  E-value: 1.65e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21493033   289 KLMKSIE---QDAVNTFTKYISPDAAKPIPITEAMRNDIIARICGEdgqVDPNCFVLAQSIVFSAMEQEHFSEFLRS 362
Cdd:pfam00615  38 KKADPDEerlKKAKEIYNEFLAPGSPKEINLDSDLREEIRENLEKE---PTRDLFDEAQAEVYELMEKDSYPRFLKS 111
RGS_SNX13 cd08719
Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 13 (SNX13) protein; ...
 383-503 1.72e-06

Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 13 (SNX13) protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the SNX13 (Sorting Nexin 13) protein, a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. The RGS-domain of SNX13 plays a major role through attenuation of Galphas-mediated signaling and regulates endocytic trafficking and degradation of the epidermal growth factor receptor. Snx13-null mice were embryonic lethal around midgestation which supports an essential role for SNX13 in mouse development and regulation of endocytosis dynamics.


Pssm-ID: 188674  Cd Length: 135  Bit Score: 47.79  E-value: 1.72e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21493033 383 ILFCESALFYFSEYMEKEDAVNILQFWLAADNF----QSQL-AAKKGQYDGQEAQNDAM--------ILYDKYFSLQATH 449
Cdd:cd08719   1 ILVNNVALSYFIDFMQSVGGQAYLFFWLTVEGYrvsaEQQLsELHLRQRGGEHQRSDVYemlraaalNIYDQYLSEKASP 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 21493033 450 PLGFDDVVRLEIESNIcREGGPLPNCFTTPLRQAWTTMEK--VFLPGFLSSNLYYK 503
Cdd:cd08719  81 RVPLDDSLVKKLLNRL-RNDTPSDLWFDDIQQKVFDIMQEdeRFYPAFKKSPAYVK 135
RGS_SNX14 cd08722
Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein; ...
 383-502 4.13e-06

Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the SNX14 (Sorting Nexin14) protein, a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. SNX14 is believed to regulates membrane trafficking in motor neurons.


Pssm-ID: 188677  Cd Length: 127  Bit Score: 46.57  E-value: 4.13e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21493033 383 ILFCESALFYFSEYMEKEDAVNILQFWLAADNFQSQ-LAAKKGQYDGQEAQNDAMILYDKYFSLQATHPLGFDDVVRLEI 461
Cdd:cd08722   1 ILDDQRLLFPFMQFLKEEGAVHLLQFCLTVEDFNRRiLNPDLTDEEKQSLHKEAQEIYKTYFLPEAPDRIHFPPDIVEEI 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 21493033 462 ESNIcrEGGPLPNCF---TTPLRQAW----TTMEKVFLPGFLSSNLYY 502
Cdd:cd08722  81 KQIL--EGGPEKIVKlrtSRPLFEAYehvySLLESVFCPLFCHSDEYF 126
RGS_RGS13 cd08716
Regulator of G protein signaling (RGS) domain found in the RGS13 protein; The RGS (Regulator ...
 298-362 1.06e-05

Regulator of G protein signaling (RGS) domain found in the RGS13 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS13 protein. RGS13 is member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS13 is predominantly expressed in T and B lymphocytes and in mast cells, and plays a role in adaptive immune responses. RGS13 also found in Rgs13, which is also expressed in dendritic cells and in neuroendocrine cells of the thymus, gastrointestinal, and respiratory tracts. Outside of the GPCR pathway, RGS5 interacts with the PIP3 protein.


Pssm-ID: 188671  Cd Length: 114  Bit Score: 44.92  E-value: 1.06e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21493033 298 AVNTFTKYISPDAAKPIPITEAMRNDIIARIcgedGQVDPNCFVLAQSIVFSAMEQEHFSEFLRS 362
Cdd:cd08716  49 ARKLFASYIQPQAPREINIDSPTRKAIIRNI----QEPTQSCFDEAQRIVYMHMERDSYPRFLES 109
RGS_R12-like cd08706
Regulator of G protein signaling (RGS) domain found in the R12 subfamily of proteins; The RGS ...
 392-501 1.45e-05

Regulator of G protein signaling (RGS) domain found in the R12 subfamily of proteins; The RGS (Regulator of G-protein Signaling) domain is an essential part of the R12 (Neuronal RGS) protein subfamily of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play a critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of G-protein signaling, controlled by RGS domain, accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP that results in reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The R12 RGS subfamily includes RGS10, RGS12 and RGS14 all of which are highly selective for G-alpha-i1 over G-alpha-q.


Pssm-ID: 188661  Cd Length: 113  Bit Score: 44.62  E-value: 1.45e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21493033 392 YFSEYMEKE-DAVNILqFWLAADNFqsqlaakKGQYDGQEAQNDAMILYDKYFSLQATHPLGFDDVVRLEIEsnICREgg 470
Cdd:cd08706  13 YFTEFLKKEfSEENIL-FWQACEKF-------KKIPDKKQLVQEAREIYDTFLSSKASSPVNIDSQAQLAEE--MLEE-- 80

                        90       100       110
                ....*....|....*....|....*....|.
gi 21493033 471 PLPNCFTTPLRQAWTTMEKVFLPGFLSSNLY 501
Cdd:cd08706  81 PHPDMFQKQQLQIFNLMKFDSYSRFLKSPLY 111
RGS_RGS3 cd08713
Regulator of G protein signaling (RGS) domain found in the RGS3 protein; The RGS (Regulator of ...
 393-503 1.69e-05

Regulator of G protein signaling (RGS) domain found in the RGS3 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS3 protein. RGS3 is a member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes. RGS3 induces apoptosis when overexpressed and is involved in cell migration through interaction with the Ephrin receptor. RGS3 exits as several splice isoforms and interacts with neuroligin, estrogen receptor-alpha, and 14-3-3 outside of the GPCR pathways.


Pssm-ID: 188668  Cd Length: 114  Bit Score: 44.47  E-value: 1.69e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21493033 393 FSEYMEKEDAVNILQFWLAADNF-----QSQLAAKkgqydgqeaqndAMILYDKYFSLQATHPLGFDDVVRLEIESNIcr 467
Cdd:cd08713  14 FRAFLQTEFSEENLEFWLACEEYkkiksQSKMASR------------AKKIFAEYIAIQSCKEVNLDSYTREHTKENL-- 79

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 21493033 468 eGGPLPNCFTTPLRQAWTTMEKVFLPGFLSSNLYYK 503
Cdd:cd08713  80 -QNPTRGCFDLAQKRIYGLMEKDSYPRFLRSDLYQD 114
RGS_RGS14 cd08743
Regulator of G protein signaling (RGS) domain found in the RGS14 protein; RGS (Regulator of ...
 389-501 2.84e-05

Regulator of G protein signaling (RGS) domain found in the RGS14 protein; RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS14 protein. RGS14 is a member of the RA/RGS subfamily of RGS proteins family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS14 belong to the R12 RGS subfamily, which includes RGS10 and RGS12, all of which are highly selective for G-alpha-i1 over G-alpha-q. RGS14 binds and regulates the subcellular localization and activities of H-Ras and Raf kinases in cells and thereby integrates G protein and Ras/Raf signaling pathways.


Pssm-ID: 188697  Cd Length: 129  Bit Score: 44.25  E-value: 2.84e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21493033 389 ALFYFSEYMEKEDAVNILQFWLAADNFQsQLAAKKGQYDGQEAQNdamiLYDKYFSLQATHPLGFDDvvRLEIESNICRE 468
Cdd:cd08743  20 GVEYFTEFLKKEFSAENVNFWKACERFQ-QIPASDTQQLAQEARK----IYNEFLSSSSQSPVNIDQ--QAWIGEDMLAT 92

                        90       100       110
                ....*....|....*....|....*....|...
gi 21493033 469 ggPLPNCFTTPLRQAWTTMEKVFLPGFLSSNLY 501
Cdd:cd08743  93 --PSPDMFRAQQLQIFNLMKFDSYARFVKSPLY 123
RGS_RGS21 cd08723
Regulator of G protein signaling (RGS) domain found in the RGS21 protein; The RGS (Regulator ...
 383-503 3.43e-05

Regulator of G protein signaling (RGS) domain found in the RGS21 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part RGS21 protein, a member of RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, apoptosis, and cell proliferation, as well as modulation of cardiac development. RGS21 is a member of the R4/RGS subfamily and its mRNA was detected only in sensory taste cells that express sweet taste receptors and the taste G-alpha subunit, gustducin, suggesting a potential role in regulating taste transduction.


Pssm-ID: 188678  Cd Length: 111  Bit Score: 43.51  E-value: 3.43e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21493033 383 ILFCESALFYFSEYMEKEDAVNILQFWLAADNFqsqlaakKGQYDGQEAQNDAMILYDKYFSLQATHPLGFDDVVRLEIE 462
Cdd:cd08723   1 LLANQAGLDAFRTFLKSEFSEENVEFWLACEDF-------KKTKSSTEIALKAQMIYSEFIQADAPKEINIDFHTRDLIS 73

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 21493033 463 SNICReggPLPNCFTTPLRQAWTTMEKVFLPGFLSSNLYYK 503
Cdd:cd08723  74 QNISE---PTLKCFDEAQSLIYCLMAKDSFPRFLKSEVYKK 111
RGS_RGS13 cd08716
Regulator of G protein signaling (RGS) domain found in the RGS13 protein; The RGS (Regulator ...
 393-503 4.08e-05

Regulator of G protein signaling (RGS) domain found in the RGS13 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS13 protein. RGS13 is member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS13 is predominantly expressed in T and B lymphocytes and in mast cells, and plays a role in adaptive immune responses. RGS13 also found in Rgs13, which is also expressed in dendritic cells and in neuroendocrine cells of the thymus, gastrointestinal, and respiratory tracts. Outside of the GPCR pathway, RGS5 interacts with the PIP3 protein.


Pssm-ID: 188671  Cd Length: 114  Bit Score: 43.38  E-value: 4.08e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21493033 393 FSEYMEKEDAVNILQFWLAADNFQSQLAAKKGQYDGQEaqndamiLYDKYFSLQATHPLGFDDVVRLEIESNICReggPL 472
Cdd:cd08716  14 YATYLKTEHSDENIEFWLACETYKKIASQRKRISMARK-------LFASYIQPQAPREINIDSPTRKAIIRNIQE---PT 83

                        90       100       110
                ....*....|....*....|....*....|.
gi 21493033 473 PNCFTTPLRQAWTTMEKVFLPGFLSSNLYYK 503
Cdd:cd08716  84 QSCFDEAQRIVYMHMERDSYPRFLESKFYQK 114
RGS_RGS2 cd08709
Regulator of G protein signaling (RGS) domain found in the RGS2 protein; The RGS (Regulator of ...
 382-501 4.45e-05

Regulator of G protein signaling (RGS) domain found in the RGS2 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS2 protein. RGS2 is a member of R4/RGS subfamily of RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G- alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS2 plays important roles in the regulation of blood pressure and the pathogenesis of human hypertension, as well as in bone formation in osteoblasts. Outside of the GPCR pathway RGS2 interacts with calmodulin, beta- COP, tubulin, PKG1-alpha, and TRPV6.


Pssm-ID: 188664  Cd Length: 114  Bit Score: 43.12  E-value: 4.45e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21493033 382 DILFCESALFYFSEYMEKEDAVNILQFWLAADNFqsqlaakKGQYDGQEAQNDAMILYDKYFSLQATHPLGFDDVVRLEI 461
Cdd:cd08709   3 ELLASKYGVAAFRAFLKSEFSEENIEFWLACEDF-------KKTKSPQKLTSKAKKIYTDFIEKEAPKEINIDFQTKTLI 75

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 21493033 462 ESNICReggPLPNCFTTPLRQAWTTMEKVFLPGFLSSNLY 501
Cdd:cd08709  76 AQNIQE---ATSGCFTAAQKRVYSLMENNSYPRFLESEFY 112
RGS_RGS4 cd08714
Regulator of G protein signaling (RGS) domain found in the RGS4 protein; The RGS (Regulator of ...
 391-501 5.21e-05

Regulator of G protein signaling (RGS) domain found in the RGS4 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS4 protein. RGS4 is a member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. RGS4 is expressed widely in brain including prefrontal cortex, striatum, locus coeruleus (LC), and hippocampus and has been implicated in regulation of opioid, cholinergic, and serotonergic signaling. Dysfunctions in RGS4 proteins are involved in etiology of Parkinson's disease, addiction, and schizophrenia. RGS4 also is up-regulated in the failing human heart. RGS4 interacts with many binding partners outside of GPCR pathways, including calmodulin, COP, Kir3, PIP, calcium/CaM, PA, ErbB3, and 14-3-3.


Pssm-ID: 188669  Cd Length: 114  Bit Score: 42.95  E-value: 5.21e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21493033 391 FYFSEYMEKedavNIlQFWLAADNFQSQLAAKKGQydgQEAQNdamiLYDKYFSLQATHPLGFDDVVRLEIESNICRegg 470
Cdd:cd08714  17 FLKSEYSEE----NI-DFWVSCEDYKKTKSPSKLS---PKARK----IYEEFISVQATKEVNLDSCTREETSRNMLE--- 81

                        90       100       110
                ....*....|....*....|....*....|.
gi 21493033 471 PLPNCFTTPLRQAWTTMEKVFLPGFLSSNLY 501
Cdd:cd08714  82 PTISCFDEAQKKIFTLMEKDSYRRFLKSRFY 112
RGS_PX cd08729
Regulator of G protein signaling domain; These uncharacterized RGS-like domains are found in ...
 388-503 6.96e-05

Regulator of G protein signaling domain; These uncharacterized RGS-like domains are found in proteins that also contain one or more PX domains. The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. As a major G-protein regulator, the RGS domain containing proteins that are involves in many crucial cellular processes. RGS proteins regulate intracellular trafficking and provide vital support for signal transduction. RGS proteins play critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. Several RGS proteins can fine-tune immune responses, others RGS proteins play important role in neuronal signals modulation. Some RGS proteins are the principal elements needed for proper vision.


Pssm-ID: 188684  Cd Length: 136  Bit Score: 43.22  E-value: 6.96e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21493033 388 SALFYFSEYMEKEDAVNILQFWLAADNFQSQLAAKKGQYDGQEAQ---------NDAMILYDKYFSLQATH---PLGFDD 455
Cdd:cd08729   5 SSLSYFMEFMDRRNRSQLVQFWLVVEGFKNPLEDTENDYSLDSSQsrswidsdkEDIAMIYETYFSDPSPSlnvPKASRD 84

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 21493033 456 VVRLEIesNICREGGPLP------NCFTTPLRQAWTTMEKVFLPGFLSSNLYYK 503
Cdd:cd08729  85 PIRLFL--NAGVNASPNEqyrkarRAVLMAQRAVYEEMEEEDFPEFKKSELFYK 136
RGS_RGS17 cd08744
Regulator of G protein signaling (RGS) domain found in the RGS17 protein; The RGS (Regulator ...
 393-501 1.29e-04

Regulator of G protein signaling (RGS) domain found in the RGS17 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS17 protein, a member of the RZ subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, the RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of the G-protein signaling controlled by the RGS domain, which accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, results in reassociation of the alpha-subunit with the beta-gamma-dimer and inhibition of downstream activity. The RZ subfamily of RGS proteins includes RGS19 (former GAIP), RGS20, and its splice variant Ret-RGS. RGS17 is a relatively non-selective GAP for G-alpha-z and other G-alpha-i/o proteins. RGS17 blocks dopamine receptor-mediated inhibition of cAMP accumulation; it also blocks thyrotropin releasing hormone-stimulated Ca++ mobilization. RGS17, like other members of RZ subfamily, can act either as a GAP or as G-protein effector antogonist.


Pssm-ID: 188698  Cd Length: 118  Bit Score: 42.02  E-value: 1.29e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21493033 393 FSEYMEKEDAVNILQFWLAADNFqsqlaakKGQYDGQEAQNDAMILYDKYFSLQATHPLGFDDVVRLEIESNICregGPL 472
Cdd:cd08744  18 FREFLRTEYSEENLLFWLACEDL-------KKEQNKKVIEEKARLIYEDYISILSPKEVSLDSRVREVINRNLL---DPN 87

                        90       100
                ....*....|....*....|....*....
gi 21493033 473 PNCFTTPLRQAWTTMEKVFLPGFLSSNLY 501
Cdd:cd08744  88 PHMYEDAQLQIYTLMHRDSFPRFLNSQIY 116
RGS_RGS19 cd08745
Regulator of G protein signaling (RGS) domain found in the RGS19 protein; The RGS (Regulator ...
 393-501 1.60e-04

Regulator of G protein signaling (RGS) domain found in the RGS19 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS19 protein (also known as GAIP), a member of the RZ subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of G-protein signaling is controlled by RGS domains, which accelerate GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, resulting in a reassociation of the alpha-subunit with the beta-gamma-dimer and an inhibition of downstream activity. As a major G-protein regulator, the RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The RZ subfamily of RGS proteins includes RGS17, RGS20, and its splice variant Ret-RGS. RGS19 participates in regulation of dopamine receptor D2R and D3R, as well as beta-adrenergic receptors .


Pssm-ID: 188699  Cd Length: 118  Bit Score: 41.58  E-value: 1.60e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21493033 393 FSEYMEKEDAVNILQFWLAADNFqsqlaakKGQYDGQEAQNDAMILYDKYFSLQATHPLGFDDVVRLEIESNICReggPL 472
Cdd:cd08745  18 FREFLRTEYSEENMLFWLACEEL-------KAEANKHVIDEKARLIYEDYISILSPKEVSLDSRVREGINRKMQE---PS 87

                        90       100
                ....*....|....*....|....*....
gi 21493033 473 PNCFTTPLRQAWTTMEKVFLPGFLSSNLY 501
Cdd:cd08745  88 SHTFDDAQLQIYTLMHRDSYPRFLNSPIY 116
RGS_RGS21 cd08723
Regulator of G protein signaling (RGS) domain found in the RGS21 protein; The RGS (Regulator ...
 293-367 4.27e-04

Regulator of G protein signaling (RGS) domain found in the RGS21 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part RGS21 protein, a member of RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, apoptosis, and cell proliferation, as well as modulation of cardiac development. RGS21 is a member of the R4/RGS subfamily and its mRNA was detected only in sensory taste cells that express sweet taste receptors and the taste G-alpha subunit, gustducin, suggesting a potential role in regulating taste transduction.


Pssm-ID: 188678  Cd Length: 111  Bit Score: 40.43  E-value: 4.27e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21493033 293 SIEQDAVNTFTKYISPDAAKPIPITEAMRNDIIARIcgedGQVDPNCFVLAQSIVFSAMEQEHFSEFLRSHHFCK 367
Cdd:cd08723  41 EIALKAQMIYSEFIQADAPKEINIDFHTRDLISQNI----SEPTLKCFDEAQSLIYCLMAKDSFPRFLKSEVYKK 111
RGS_RGS1 cd08715
Regulator of G protein signaling (RGS) domain found in the RGS1 protein; The RGS (Regulator of ...
 302-365 6.41e-04

Regulator of G protein signaling (RGS) domain found in the RGS1 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS1 protein. RGS1 is a member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS 1 is expressed predominantly in hematopoietic compartments, including T and B lymphocytes, and may play a major role in chemokine-mediated homing of lymphocytes to secondary lymphoid organs. In addition, RGS1 interacts with calmodulin and 14-3-3 protein outside of the GPCR pathway.


Pssm-ID: 188670  Cd Length: 114  Bit Score: 39.93  E-value: 6.41e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21493033 302 FTKYISPDAAKPIPITEAMRNDIIARIcgedGQVDPNCFVLAQSIVFSAMEQEHFSEFLRSHHF 365
Cdd:cd08715  52 YKEFVQSDAAKQINIDFRTRESTAKKI----KAPTPTCFDEAQKVIYILMERDSYPRFLKSDIY 111
RGS_RGS1 cd08715
Regulator of G protein signaling (RGS) domain found in the RGS1 protein; The RGS (Regulator of ...
 380-503 7.78e-04

Regulator of G protein signaling (RGS) domain found in the RGS1 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS1 protein. RGS1 is a member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS 1 is expressed predominantly in hematopoietic compartments, including T and B lymphocytes, and may play a major role in chemokine-mediated homing of lymphocytes to secondary lymphoid organs. In addition, RGS1 interacts with calmodulin and 14-3-3 protein outside of the GPCR pathway.


Pssm-ID: 188670  Cd Length: 114  Bit Score: 39.55  E-value: 7.78e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21493033 380 LADILFCESALFYFSEYMEKEDAVNILQFWLAADNFqsqlaaKKGQYDgqEAQNDAMILYDKYFSLQATHPLGFDDVVRl 459
Cdd:cd08715   1 LEKLLASQTGQNVFRSFLKSEFSEENIEFWLACEDY------KKTESD--LLPCKAEEIYKEFVQSDAAKQINIDFRTR- 71

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 21493033 460 eiESNICREGGPLPNCFTTPLRQAWTTMEKVFLPGFLSSNLYYK 503
Cdd:cd08715  72 --ESTAKKIKAPTPTCFDEAQKVIYILMERDSYPRFLKSDIYLN 113
RGS_RGS20 cd08746
Regulator of G protein signaling (RGS) domain found in the RGS20 protein; The RGS (Regulator ...
 383-501 9.83e-04

Regulator of G protein signaling (RGS) domain found in the RGS20 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS20 protein (also known as RGSZ1), a member of the RZ subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of G-protein signaling is controlled by the RGS domain, which accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP resulting in reassociation of the alpha-subunit with the beta-gamma-dimer and inhibition of downstream activity. As a major G-protein regulator, the RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The RZ subfamily of RGS proteins include RGS17, RGS19 (former GAIP), and the splice variant of RGS20, Ret-RGS. RGS20 is expressed exclusively in brain, with the highest concentrations in the temporal lobe and the caudate nucleus and may play a role in signaling regulation in these brain regions. RGS20 acts as a GAP of both G-alpha-z and G-alpha-I and controls signaling in the mu opioid receptor pathway.


Pssm-ID: 188700 [Multi-domain]  Cd Length: 167  Bit Score: 40.36  E-value: 9.83e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21493033 383 ILFCESALFYFSEYMEKEDAVNILQFWLAADNFQSQlaAKKGQydgqeAQNDAMILYDKYFSLQATHPLGFDDVVRLEIE 462
Cdd:cd08746  57 LMLTPAGRNAFREFLRTEFSEENMLFWMACEELKKE--ANKSV-----IEEKARIIYEDYISILSPKEVSLDSRVREVIN 129

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 21493033 463 SNICReggPLPNCFTTPLRQAWTTMEKVFLPGFLSSNLY 501
Cdd:cd08746 130 RNMLE---PSQHTFDDAQLQIYTLMHRDSYPRFMNSAIY 165
RGS_PX cd08729
Regulator of G protein signaling domain; These uncharacterized RGS-like domains are found in ...
 130-161 1.29e-03

Regulator of G protein signaling domain; These uncharacterized RGS-like domains are found in proteins that also contain one or more PX domains. The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. As a major G-protein regulator, the RGS domain containing proteins that are involves in many crucial cellular processes. RGS proteins regulate intracellular trafficking and provide vital support for signal transduction. RGS proteins play critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. Several RGS proteins can fine-tune immune responses, others RGS proteins play important role in neuronal signals modulation. Some RGS proteins are the principal elements needed for proper vision.


Pssm-ID: 188684  Cd Length: 136  Bit Score: 39.37  E-value: 1.29e-03
                        10        20        30
                ....*....|....*....|....*....|..
gi 21493033 130 LHDTIVLPYFIQFMELRRMEHLVKFWLEAESF 161
Cdd:cd08729   1 LRDPSSLSYFMEFMDRRNRSQLVQFWLVVEGF 32
RGS_RGS12 cd08742
Regulator of G protein signaling (RGS) domain found in the RGS12 protein; RGS (Regulator of ...
 392-501 2.26e-03

Regulator of G protein signaling (RGS) domain found in the RGS12 protein; RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS12 protein. RGS12 is a member of the RA/RGS subfamily of RGS proteins family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS12 belong to the R12 RGS subfamily, which includes RGS10 and RGS14, all of which are highly selective for G-alpha-i1 over G-alpha-q. RGS12 exist in multiple splice variants: RGS12s (short) contains the core RGS/RBD/GoLoco domains, while RGS12L (long) has additional N-terminal PDZ and PTB domains. RGS12 splice variants show distinct expression patterns, suggesting that they have discrete functions during mouse embryogenesis. RGS12 also may play a critical role in coordinating Ras-dependent signals that are required for promoting and maintaining neuronal differentiation.


Pssm-ID: 188696  Cd Length: 115  Bit Score: 38.50  E-value: 2.26e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21493033 392 YFSEYMEKEDAVNILQFWLAADNFQSQLAakkgqYDGQEAQNDAMILYDKYFSLQATHPLGFDDvvRLEIESNICRegGP 471
Cdd:cd08742  13 YFSEFLRKEFSEENILFWQACEYFNHVPA-----HDKKELSYRAREIFSKFLCSKATTPVNIDS--QAQLADDILN--AP 83

                        90       100       110
                ....*....|....*....|....*....|
gi 21493033 472 LPNCFTTPLRQAWTTMEKVFLPGFLSSNLY 501
Cdd:cd08742  84 HPDMFKEQQLQIFNLMKFDSYTRFLKSPLY 113
RGS_RZ-like cd08718
Regulator of G protein signaling (RGS) domain found in the RZ protein; The RGS (Regulator of ...
 392-501 2.50e-03

Regulator of G protein signaling (RGS) domain found in the RZ protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RZ subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of G-protein signaling is controlled by RGS domains, which accelerate GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in reassociation of the alpha-subunit with the beta-gamma-dimer and inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The RZ subfamily of RGS proteins includes RGS17, RGS19 (former GAIP), RGS20, and its splice variant Ret-RGS.


Pssm-ID: 188673  Cd Length: 118  Bit Score: 38.21  E-value: 2.50e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21493033 392 YFSEYMEKEDAVNILQFWLAADNFqsqlaakKGQYDGQEAQNDAMILYDKYFSLQATHPLGFDDVVRLEIESNICReggP 471
Cdd:cd08718  17 VFREFLRTEYSEENMLFWLACEEL-------KKEANKHVIEEKARLIYEDYISILSPKEVSLDSRVREVINRNMLE---P 86

                        90       100       110
                ....*....|....*....|....*....|
gi 21493033 472 LPNCFTTPLRQAWTTMEKVFLPGFLSSNLY 501
Cdd:cd08718  87 SPHTFDDAQLQIYTLMHRDSYPRFLNSAIY 116
RGS_SNX25 cd08720
Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 25 (SNX25) protein; ...
 392-503 2.96e-03

Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 25 (SNX25) protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the SNX25 (Sorting Nexin 25) protein, a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. SNX25 is a member of the Dopamine receptors (DAR) signalplex and regulates the trafficking of D1 and D2 DARs.


Pssm-ID: 188675  Cd Length: 110  Bit Score: 37.78  E-value: 2.96e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21493033 392 YFSEYMEKEDAVNILQFWLAADNFQSqlaAKKGQYDgqeaQNDAMILYDkyFSLQATHPLGFDDVVRLEIESNICREGGp 471
Cdd:cd08720  10 YLSQFLERMDSQALIGFWEAVEELRS---ANKSEWH----QLGAEIFYT--FIVEPTAEIKVDKSLRKRIEQFLLGDKG- 79

                        90       100       110
                ....*....|....*....|....*....|..
gi 21493033 472 lPNCFTTPLRQAWTTMEKVFLPGFLSSNLYYK 503
Cdd:cd08720  80 -PEVFYEVQENVVETLEEKYYPSFVVSDQYKQ 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH