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Conserved domains on  [gi|6319979|ref|NP_010059|]
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Fmp45p [Saccharomyces cerevisiae S288C]

Protein Classification

SUR7/PalI family protein( domain architecture ID 10535294)

SUR7/PalI family protein such as fungal protein SUR7, that is involved in sporulation and affects the sphingolipid composition of the plasma membrane, and pH-response regulator protein palI/RIM9, that is required for the proteolytic cleavage of the transcriptional repressor RIM101 in response to alkaline ambient pH

Gene Ontology:  GO:0005886
PubMed:  11784867

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SUR7 pfam06687
SUR7/PalI family; This family consists of several fungal-specific SUR7 proteins. Its activity ...
 22-205 8.20e-63

SUR7/PalI family; This family consists of several fungal-specific SUR7 proteins. Its activity regulates expression of RVS161, a homolog of human endophilin, suggesting a function for both in endocytosis. The protein carries four transmembrane domains and is thus likely to act as an anchoring protein for the eisosome to the plasma membrane. Eisosomes are the immobile protein complexes, that include the proteins Pil1 and Lsp1, which co-localize with sites of protein and lipid endocytosis at the plasma membrane. SUR7 protein may play a role in sporulation. This family also includes PalI which is part of a pH signal transduction cascade. Based on the similarity of PalI to the yeast Rim9 meiotic signal transduction component it has been suggested that PalI might be a membrane sensor for ambient pH.


:

Pssm-ID: 399580  Cd Length: 201  Bit Score: 197.55  E-value: 8.20e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319979     22 TFFLILSGGRESGTLKNFYWLQADTNGFNSAPSTTRWYNYNWCGYEDGQLANCSSRAPAKPFSPRDNFGNSVN--LPSSF 99
Cdd:pfam06687  16 LIFVILGGISNSSPLNNIYLLEADTSGISGAPDFYRWGVWGYCGNSDNNNTNCSKPSAGYPFDPLDNFGTNSNgkLPSSF 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319979    100 RNNRDTYYYLSRVGWAMLLISLFFIVLALVPGFLATFLPFKAVPVLYCVLSWLAFFFIILAACLYTGCYVKARKTFRNSG 179
Cdd:pfam06687  96 RDTLSTYYYLSRFMFIVHIIALFFTVIALILGLLAIFSHSRRGLLVNLLLSFLAFLFTLLAALLDTALFVKARNAFKDYG 175

                         170       180
                  ....*....|....*....|....*.
gi 6319979    180 RSARLGPKNFAFIWTSVFLMLVNAIW 205
Cdd:pfam06687 176 ISASLGVKWFAFLWLAVAAALLSLIS 201
 
Name Accession Description Interval E-value
SUR7 pfam06687
SUR7/PalI family; This family consists of several fungal-specific SUR7 proteins. Its activity ...
 22-205 8.20e-63

SUR7/PalI family; This family consists of several fungal-specific SUR7 proteins. Its activity regulates expression of RVS161, a homolog of human endophilin, suggesting a function for both in endocytosis. The protein carries four transmembrane domains and is thus likely to act as an anchoring protein for the eisosome to the plasma membrane. Eisosomes are the immobile protein complexes, that include the proteins Pil1 and Lsp1, which co-localize with sites of protein and lipid endocytosis at the plasma membrane. SUR7 protein may play a role in sporulation. This family also includes PalI which is part of a pH signal transduction cascade. Based on the similarity of PalI to the yeast Rim9 meiotic signal transduction component it has been suggested that PalI might be a membrane sensor for ambient pH.


Pssm-ID: 399580  Cd Length: 201  Bit Score: 197.55  E-value: 8.20e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319979     22 TFFLILSGGRESGTLKNFYWLQADTNGFNSAPSTTRWYNYNWCGYEDGQLANCSSRAPAKPFSPRDNFGNSVN--LPSSF 99
Cdd:pfam06687  16 LIFVILGGISNSSPLNNIYLLEADTSGISGAPDFYRWGVWGYCGNSDNNNTNCSKPSAGYPFDPLDNFGTNSNgkLPSSF 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319979    100 RNNRDTYYYLSRVGWAMLLISLFFIVLALVPGFLATFLPFKAVPVLYCVLSWLAFFFIILAACLYTGCYVKARKTFRNSG 179
Cdd:pfam06687  96 RDTLSTYYYLSRFMFIVHIIALFFTVIALILGLLAIFSHSRRGLLVNLLLSFLAFLFTLLAALLDTALFVKARNAFKDYG 175

                         170       180
                  ....*....|....*....|....*.
gi 6319979    180 RSARLGPKNFAFIWTSVFLMLVNAIW 205
Cdd:pfam06687 176 ISASLGVKWFAFLWLAVAAALLSLIS 201
 
Name Accession Description Interval E-value
SUR7 pfam06687
SUR7/PalI family; This family consists of several fungal-specific SUR7 proteins. Its activity ...
 22-205 8.20e-63

SUR7/PalI family; This family consists of several fungal-specific SUR7 proteins. Its activity regulates expression of RVS161, a homolog of human endophilin, suggesting a function for both in endocytosis. The protein carries four transmembrane domains and is thus likely to act as an anchoring protein for the eisosome to the plasma membrane. Eisosomes are the immobile protein complexes, that include the proteins Pil1 and Lsp1, which co-localize with sites of protein and lipid endocytosis at the plasma membrane. SUR7 protein may play a role in sporulation. This family also includes PalI which is part of a pH signal transduction cascade. Based on the similarity of PalI to the yeast Rim9 meiotic signal transduction component it has been suggested that PalI might be a membrane sensor for ambient pH.


Pssm-ID: 399580  Cd Length: 201  Bit Score: 197.55  E-value: 8.20e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319979     22 TFFLILSGGRESGTLKNFYWLQADTNGFNSAPSTTRWYNYNWCGYEDGQLANCSSRAPAKPFSPRDNFGNSVN--LPSSF 99
Cdd:pfam06687  16 LIFVILGGISNSSPLNNIYLLEADTSGISGAPDFYRWGVWGYCGNSDNNNTNCSKPSAGYPFDPLDNFGTNSNgkLPSSF 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319979    100 RNNRDTYYYLSRVGWAMLLISLFFIVLALVPGFLATFLPFKAVPVLYCVLSWLAFFFIILAACLYTGCYVKARKTFRNSG 179
Cdd:pfam06687  96 RDTLSTYYYLSRFMFIVHIIALFFTVIALILGLLAIFSHSRRGLLVNLLLSFLAFLFTLLAALLDTALFVKARNAFKDYG 175

                         170       180
                  ....*....|....*....|....*.
gi 6319979    180 RSARLGPKNFAFIWTSVFLMLVNAIW 205
Cdd:pfam06687 176 ISASLGVKWFAFLWLAVAAALLSLIS 201
Claudin_2 pfam13903
PMP-22/EMP/MP20/Claudin tight junction; Members of this family are claudins, that form tight ...
 40-145 6.98e-03

PMP-22/EMP/MP20/Claudin tight junction; Members of this family are claudins, that form tight junctions between cells.


Pssm-ID: 372799 [Multi-domain]  Cd Length: 191  Bit Score: 37.02  E-value: 6.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319979     40 YWLQAD--TNGFNSAPSTTRWYNYNWCGYEDGQLANCssrapakpFSPRDNFGNSVNLPSSFRNNRDTYY---YLSRVGW 114
Cdd:pfam13903  15 YWLVLDvaLTGINNYTCLFAHLGLWRHCFKSEVDVDS--------DNQTRFFGCLNQVPNPFPTFEEEIVsfsVTSLPGL 86

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 6319979    115 -----AMLLISLFFIVLALVPGFLAtfLPFKAVPVL 145
Cdd:pfam13903  87 trfvqAFAILSLVLIVCGVVCGLLA--LPKQSVFLL 120
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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