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Conserved domains on  [gi|398365939|ref|NP_011674|]
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exosome non-catalytic core subunit MTR3 [Saccharomyces cerevisiae S288C]

Protein Classification

exosome complex component( domain architecture ID 3202)

exosome complex component, such as exosome complex component RRP45, a component of the exosome that plays an important role in RNA turnover, maturation of stable RNA species such as rRNA, snRNA and snoRNA, quality control of mRNA, and the degradation of RNA processing by-products and non-coding transcripts

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RNase_PH super family cl03114
RNase PH-like 3'-5' exoribonucleases; RNase PH-like 3'-5' exoribonucleases are enzymes that ...
 48-247 1.21e-24

RNase PH-like 3'-5' exoribonucleases; RNase PH-like 3'-5' exoribonucleases are enzymes that catalyze the 3' to 5' processing and decay of RNA substrates. Evolutionarily related members can be fond in prokaryotes, archaea, and eukaryotes. Bacterial ribonuclease PH contains a single copy of this domain, and removes nucleotide residues following the -CCA terminus of tRNA. Polyribonucleotide nucleotidyltransferase (PNPase) contains two tandem copies of the domain and is involved in mRNA degradation in a 3'-5' direction. Archaeal exosomes contain two individually encoded RNase PH-like 3'-5' exoribonucleases and are required for 3' processing of the 5.8S rRNA. The eukaryotic exosome core is composed of six individually encoded RNase PH-like subunits, but it is not a phosphorolytic enzyme per se; it directly associates with Rrp44 and Rrp6, which are hydrolytic exoribonucleases related to bacterial RNase II/R and RNase D. All members of the RNase PH-like family form ring structures by oligomerization of six domains or subunits, except for a total of 3 subunits with tandem repeats in the case of PNPase, with a central channel through which the RNA substrate must pass to gain access to the phosphorolytic active sites.


The actual alignment was detected with superfamily member cd11371:

Pssm-ID: 446015 [Multi-domain]  Cd Length: 210  Bit Score: 97.25  E-value: 1.21e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365939  48 LHTGFIENCNGSALVEARSlghqTSLITAVYGPRSIRGS--FTSQGTISIQLK-----NGLLEKYN-TNELKEVSSFLMG 119
Cdd:cd11371    6 LKTGVVSQAKGSAYVELGN----TKVICSVYGPRPIPGRteFSDRGRLNCEVKfapfaTPGRRRHGqDSEERELSSLLHQ 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365939 120 IFNSVVNLSRYPKSGIDIFVYLTydkdltnnpQDDdsqskmmssqiSSLIPHCITSITLALADAGIELVDMAGAGEAN-- 197
Cdd:cd11371   82 ALEPAVRLEKYPKSQIDVFVTVL---------ESD-----------GSVLAAAITAASLALADAGIEMYDLVTACSAAli 141

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 398365939 198 ------------------GTVVSFIKNGEEIVGFWKD-DGDDEDLLECLDRCKEQYNRYRDLMISCLMN 247
Cdd:cd11371  142 gdellldptreeeeassgGVMLAYMPSLNQVTQLWQSgEMDVDQLEEALDLCIDGCNRIHPVVRQALLE 210
 
Name Accession Description Interval E-value
RNase_PH_MTR3 cd11371
MTR3 subunit of eukaryotic exosome; The MTR3 subunit of eukaryotic exosome is a member of the ...
 48-247 1.21e-24

MTR3 subunit of eukaryotic exosome; The MTR3 subunit of eukaryotic exosome is a member of the RNase_PH family, named after the bacterial Ribonuclease PH, a 3'-5' exoribonuclease. Structurally all members of this family form hexameric rings (trimers of Rrp41-Rrp45, Rrp46-Rrp43, and Mtr3-Rrp42 dimers). The eukaryotic exosome core is composed of six individually encoded RNase PH-like subunits and three additional proteins (Rrp4, Csl4 and Rrp40) that form a stable cap and contain RNA-binding domains. The RNase PH-like subunits are no longer phosphorolytic enzymes, the exosome directly associates with Rrp44 and Rrp6, hydrolytic exoribonucleases related to bacterial RNase II/R and RNase D. The exosome plays an important role in RNA turnover. It plays a crucial role in the maturation of stable RNA species such as rRNA, snRNA and snoRNA, quality control of mRNA, and the degradation of RNA processing by-products and non-coding transcripts.


Pssm-ID: 206776 [Multi-domain]  Cd Length: 210  Bit Score: 97.25  E-value: 1.21e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365939  48 LHTGFIENCNGSALVEARSlghqTSLITAVYGPRSIRGS--FTSQGTISIQLK-----NGLLEKYN-TNELKEVSSFLMG 119
Cdd:cd11371    6 LKTGVVSQAKGSAYVELGN----TKVICSVYGPRPIPGRteFSDRGRLNCEVKfapfaTPGRRRHGqDSEERELSSLLHQ 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365939 120 IFNSVVNLSRYPKSGIDIFVYLTydkdltnnpQDDdsqskmmssqiSSLIPHCITSITLALADAGIELVDMAGAGEAN-- 197
Cdd:cd11371   82 ALEPAVRLEKYPKSQIDVFVTVL---------ESD-----------GSVLAAAITAASLALADAGIEMYDLVTACSAAli 141

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 398365939 198 ------------------GTVVSFIKNGEEIVGFWKD-DGDDEDLLECLDRCKEQYNRYRDLMISCLMN 247
Cdd:cd11371  142 gdellldptreeeeassgGVMLAYMPSLNQVTQLWQSgEMDVDQLEEALDLCIDGCNRIHPVVRQALLE 210
RNase_PH pfam01138
3' exoribonuclease family, domain 1; This family includes 3'-5' exoribonucleases. Ribonuclease ...
 45-186 2.20e-15

3' exoribonuclease family, domain 1; This family includes 3'-5' exoribonucleases. Ribonuclease PH contains a single copy of this domain, and removes nucleotide residues following the -CCA terminus of tRNA. Polyribonucleotide nucleotidyltransferase (PNPase) contains two tandem copies of the domain. PNPase is involved in mRNA degradation in a 3'-5' direction. The exosome is a 3'-5' exoribonuclease complex that is required for 3' processing of the 5.8S rRNA. Three of its five protein components contain a copy of this domain. A hypothetical protein from S. pombe appears to belong to an uncharacterized subfamily. This subfamily is found in both eukaryotes and archaebacteria.


Pssm-ID: 426074 [Multi-domain]  Cd Length: 129  Bit Score: 70.31  E-value: 2.20e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365939   45 ELSLHTGFIENCNGSALVEarsLGhQTSLITAVYGPRSIRGSF-TSQGTISIQLKNGLL-------EKYNTNELKEVSSF 116
Cdd:pfam01138   4 PIEIETGVLSQADGSALVE---LG-DTKVLATVTGPIEPKEDRdFAPGRLTVEYELAPFasgerpgEGRPSEREIEISRL 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365939  117 LMGIFNSVVNLSRYPKSGIDIFVYLTydkdltnnpQDDDSqskmmssqissLIPHCITSITLALADAGIE 186
Cdd:pfam01138  80 IDRALRPSIPLEGYPRWTIRIDVTVL---------SSDGS-----------LLDAAINAASLALADAGIP 129
PRK03983 PRK03983
exosome complex exonuclease Rrp41; Provisional
 51-201 6.37e-10

exosome complex exonuclease Rrp41; Provisional


Pssm-ID: 235187 [Multi-domain]  Cd Length: 244  Bit Score: 57.72  E-value: 6.37e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365939  51 GFIENCNGSALVEarsLGhQTSLITAVYGPRSI---RGSFTSQGTISIqlknglleKYN-----TNELK---------EV 113
Cdd:PRK03983  32 GVLKNADGSAYLE---WG-NNKIIAAVYGPREMhprHLQLPDRAVLRV--------RYNmapfsVDERKrpgpdrrsiEI 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365939 114 SSFLMGIFNSVVNLSRYPKSGIDIFVYLTydkdltnnpQDDdsqskmMSSQISsliphCITSITLALADAGIELVDMAGA 193
Cdd:PRK03983 100 SKVIREALEPAIMLELFPRTVIDVFIEVL---------QAD------AGTRVA-----GITAASLALADAGIPMRDLVAG 159

                        170
                 ....*....|.
gi 398365939 194 ---GEANGTVV 201
Cdd:PRK03983 160 cavGKVDGVIV 170
 
Name Accession Description Interval E-value
RNase_PH_MTR3 cd11371
MTR3 subunit of eukaryotic exosome; The MTR3 subunit of eukaryotic exosome is a member of the ...
 48-247 1.21e-24

MTR3 subunit of eukaryotic exosome; The MTR3 subunit of eukaryotic exosome is a member of the RNase_PH family, named after the bacterial Ribonuclease PH, a 3'-5' exoribonuclease. Structurally all members of this family form hexameric rings (trimers of Rrp41-Rrp45, Rrp46-Rrp43, and Mtr3-Rrp42 dimers). The eukaryotic exosome core is composed of six individually encoded RNase PH-like subunits and three additional proteins (Rrp4, Csl4 and Rrp40) that form a stable cap and contain RNA-binding domains. The RNase PH-like subunits are no longer phosphorolytic enzymes, the exosome directly associates with Rrp44 and Rrp6, hydrolytic exoribonucleases related to bacterial RNase II/R and RNase D. The exosome plays an important role in RNA turnover. It plays a crucial role in the maturation of stable RNA species such as rRNA, snRNA and snoRNA, quality control of mRNA, and the degradation of RNA processing by-products and non-coding transcripts.


Pssm-ID: 206776 [Multi-domain]  Cd Length: 210  Bit Score: 97.25  E-value: 1.21e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365939  48 LHTGFIENCNGSALVEARSlghqTSLITAVYGPRSIRGS--FTSQGTISIQLK-----NGLLEKYN-TNELKEVSSFLMG 119
Cdd:cd11371    6 LKTGVVSQAKGSAYVELGN----TKVICSVYGPRPIPGRteFSDRGRLNCEVKfapfaTPGRRRHGqDSEERELSSLLHQ 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365939 120 IFNSVVNLSRYPKSGIDIFVYLTydkdltnnpQDDdsqskmmssqiSSLIPHCITSITLALADAGIELVDMAGAGEAN-- 197
Cdd:cd11371   82 ALEPAVRLEKYPKSQIDVFVTVL---------ESD-----------GSVLAAAITAASLALADAGIEMYDLVTACSAAli 141

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 398365939 198 ------------------GTVVSFIKNGEEIVGFWKD-DGDDEDLLECLDRCKEQYNRYRDLMISCLMN 247
Cdd:cd11371  142 gdellldptreeeeassgGVMLAYMPSLNQVTQLWQSgEMDVDQLEEALDLCIDGCNRIHPVVRQALLE 210
RNase_PH pfam01138
3' exoribonuclease family, domain 1; This family includes 3'-5' exoribonucleases. Ribonuclease ...
 45-186 2.20e-15

3' exoribonuclease family, domain 1; This family includes 3'-5' exoribonucleases. Ribonuclease PH contains a single copy of this domain, and removes nucleotide residues following the -CCA terminus of tRNA. Polyribonucleotide nucleotidyltransferase (PNPase) contains two tandem copies of the domain. PNPase is involved in mRNA degradation in a 3'-5' direction. The exosome is a 3'-5' exoribonuclease complex that is required for 3' processing of the 5.8S rRNA. Three of its five protein components contain a copy of this domain. A hypothetical protein from S. pombe appears to belong to an uncharacterized subfamily. This subfamily is found in both eukaryotes and archaebacteria.


Pssm-ID: 426074 [Multi-domain]  Cd Length: 129  Bit Score: 70.31  E-value: 2.20e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365939   45 ELSLHTGFIENCNGSALVEarsLGhQTSLITAVYGPRSIRGSF-TSQGTISIQLKNGLL-------EKYNTNELKEVSSF 116
Cdd:pfam01138   4 PIEIETGVLSQADGSALVE---LG-DTKVLATVTGPIEPKEDRdFAPGRLTVEYELAPFasgerpgEGRPSEREIEISRL 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365939  117 LMGIFNSVVNLSRYPKSGIDIFVYLTydkdltnnpQDDDSqskmmssqissLIPHCITSITLALADAGIE 186
Cdd:pfam01138  80 IDRALRPSIPLEGYPRWTIRIDVTVL---------SSDGS-----------LLDAAINAASLALADAGIP 129
RNase_PH_archRRP41 cd11366
RRP41 subunit of archaeal exosome; The RRP41 subunit of the archaeal exosome is a member of ...
 45-201 1.18e-10

RRP41 subunit of archaeal exosome; The RRP41 subunit of the archaeal exosome is a member of the RNase_PH family, named after the bacterial Ribonuclease PH, a 3'-5' exoribonuclease. Structurally all members of this family form hexameric rings (trimers of dimers). In archaea, the ring is formed by three Rrp41:Rrp42 dimers. The central chamber within the ring contains three phosphorolytic active sites located in an Rrp41 pocket at the interface between Rrp42 and Rrp41. The ring is capped by three copies of Rrp4 and/or Csl4 which contain putative RNA interaction domains. The archaeal exosome degrades single-stranded RNA (ssRNA) in the 3'-5' direction, but also can catalyze the reverse reaction of adding nucleoside diphosphates to the 3'-end of RNA which has been shown to lead to the formation of poly-A-rich tails on RNA.


Pssm-ID: 206771 [Multi-domain]  Cd Length: 214  Bit Score: 59.27  E-value: 1.18e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365939  45 ELSLHTGFIENCNGSALVEarsLGhQTSLITAVYGPRSI---RGSFTSQGTISIqlknglleKYN-----TNELK----- 111
Cdd:cd11366    4 PIKIEVGVLKNADGSAYVE---WG-NNKIIAAVYGPREVhprHLQLPDRAVIRV--------RYNmapfsVDERKrpgpd 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365939 112 ----EVSSFLMGIFNSVVNLSRYPKSGIDIFVYLTydkdltnnpQDDdsqskmMSSQISsliphCITSITLALADAGIEL 187
Cdd:cd11366   72 rreiEISKVIKEALEPAIILEEFPRTAIDVFVEVL---------QAD------AGTRVA-----GLNAASLALADAGIPM 131

                        170
                 ....*....|....*..
gi 398365939 188 VDMAGA---GEANGTVV 201
Cdd:cd11366  132 RDLVAAcaaGKVDGKIV 148
RNase_PH_RRP41 cd11370
RRP41 subunit of eukaryotic exosome; The RRP41 subunit of eukaryotic exosome is a member of ...
 45-189 2.09e-10

RRP41 subunit of eukaryotic exosome; The RRP41 subunit of eukaryotic exosome is a member of the RNase_PH family, named after the bacterial Ribonuclease PH, a 3'-5' exoribonuclease. Structurally all members of this family form hexameric rings (trimers of Rrp41-Rrp45, Rrp46-Rrp43, and Mtr3-Rrp42 dimers). The eukaryotic exosome core is composed of six individually encoded RNase PH-like subunits and three additional proteins (Rrp4, Csl4 and Rrp40) that form a stable cap and contain RNA-binding domains. The RNase PH-like subunits are no longer phosphorolytic enzymes, the exosome directly associates with Rrp44 and Rrp6, hydrolytic exoribonucleases related to bacterial RNase II/R and RNase D. The exosome plays an important role in RNA turnover. It plays a crucial role in the maturation of stable RNA species such as rRNA, snRNA and snoRNA, quality control of mRNA, and the degradation of RNA processing by-products and non-coding transcripts.


Pssm-ID: 206775 [Multi-domain]  Cd Length: 226  Bit Score: 58.71  E-value: 2.09e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365939  45 ELSLHTgfieNCNGSALVEarsLGHqTSLITAVYGPRSIRGS---FTSQGTISIQlkngllekYN-----TNELK----- 111
Cdd:cd11370   18 RIGVFS----SADGSAYLE---QGN-TKVLAAVYGPHEPRNRsqaLHDRAVVNCE--------YSmatfsTGERKrrgkg 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365939 112 -----EVSSFLMGIFNSVVNLSRYPKSGIDIFVYLTydkdltnnpQDDdsqskmmssqiSSLIPHCITSITLALADAGIE 186
Cdd:cd11370   82 drrstELSLAIRQTFEAVILTHLYPRSQIDIYVQVL---------QAD-----------GGLLAACINAATLALIDAGIP 141


                 ...
gi 398365939 187 LVD 189
Cdd:cd11370  142 MKD 144
PRK03983 PRK03983
exosome complex exonuclease Rrp41; Provisional
 51-201 6.37e-10

exosome complex exonuclease Rrp41; Provisional


Pssm-ID: 235187 [Multi-domain]  Cd Length: 244  Bit Score: 57.72  E-value: 6.37e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365939  51 GFIENCNGSALVEarsLGhQTSLITAVYGPRSI---RGSFTSQGTISIqlknglleKYN-----TNELK---------EV 113
Cdd:PRK03983  32 GVLKNADGSAYLE---WG-NNKIIAAVYGPREMhprHLQLPDRAVLRV--------RYNmapfsVDERKrpgpdrrsiEI 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365939 114 SSFLMGIFNSVVNLSRYPKSGIDIFVYLTydkdltnnpQDDdsqskmMSSQISsliphCITSITLALADAGIELVDMAGA 193
Cdd:PRK03983 100 SKVIREALEPAIMLELFPRTVIDVFIEVL---------QAD------AGTRVA-----GITAASLALADAGIPMRDLVAG 159

                        170
                 ....*....|.
gi 398365939 194 ---GEANGTVV 201
Cdd:PRK03983 160 cavGKVDGVIV 170
RNase_PH_RRP46 cd11372
RRP46 subunit of eukaryotic exosome; The RRP46 subunit of eukaryotic exosome is a member of ...
 45-193 4.14e-06

RRP46 subunit of eukaryotic exosome; The RRP46 subunit of eukaryotic exosome is a member of the RNase_PH family, named after the bacterial Ribonuclease PH, a 3'-5' exoribonuclease. Structurally all members of this family form hexameric rings (trimers of Rrp41-Rrp45, Rrp46-Rrp43, and Mtr3-Rrp42 dimers). The eukaryotic exosome core is composed of six individually encoded RNase PH-like subunits and three additional proteins (Rrp4, Csl4 and Rrp40) that form a stable cap and contain RNA-binding domains. The RNase PH-like subunits are no longer phosphorolytic enzymes, the exosome directly associates with Rrp44 and Rrp6, hydrolytic exoribonucleases related to bacterial RNase II/R and RNase D. The exosome plays an important role in RNA turnover. It plays a crucial role in the maturation of stable RNA species such as rRNA, snRNA and snoRNA, quality control of mRNA, and the degradation of RNA processing by-products and non-coding transcripts.


Pssm-ID: 206777 [Multi-domain]  Cd Length: 199  Bit Score: 46.02  E-value: 4.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365939  45 ELSLHTGFIENCNGSAlvearSLGH-QTSLITAVYGPR--SIRGSFTSQGTISIQL--KNGLlekyNTNELKEVSSFLMG 119
Cdd:cd11372    3 PLSCELGLLSRADGSA-----RFSQgDTSVLAAVYGPIevKLRKELPDRATLEVIVrpKSGL----PGVKEKLLELLLRS 73

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 398365939 120 IFNSVVNLSRYPKSGIDIFVYLTydkdltnnpQDDdsqskmmssqiSSLIPHCITSITLALADAGIELVDMAGA 193
Cdd:cd11372   74 TLEPIILLHLHPRTLISVVLQVL---------QDD-----------GSLLACAINAACLALLDAGVPMKGLFAA 127
RNase_PH cd11358
RNase PH-like 3'-5' exoribonucleases; RNase PH-like 3'-5' exoribonucleases are enzymes that ...
 46-188 6.20e-04

RNase PH-like 3'-5' exoribonucleases; RNase PH-like 3'-5' exoribonucleases are enzymes that catalyze the 3' to 5' processing and decay of RNA substrates. Evolutionarily related members can be fond in prokaryotes, archaea, and eukaryotes. Bacterial ribonuclease PH contains a single copy of this domain, and removes nucleotide residues following the -CCA terminus of tRNA. Polyribonucleotide nucleotidyltransferase (PNPase) contains two tandem copies of the domain and is involved in mRNA degradation in a 3'-5' direction. Archaeal exosomes contain two individually encoded RNase PH-like 3'-5' exoribonucleases and are required for 3' processing of the 5.8S rRNA. The eukaryotic exosome core is composed of six individually encoded RNase PH-like subunits, but it is not a phosphorolytic enzyme per se; it directly associates with Rrp44 and Rrp6, which are hydrolytic exoribonucleases related to bacterial RNase II/R and RNase D. All members of the RNase PH-like family form ring structures by oligomerization of six domains or subunits, except for a total of 3 subunits with tandem repeats in the case of PNPase, with a central channel through which the RNA substrate must pass to gain access to the phosphorolytic active sites.


Pssm-ID: 206766 [Multi-domain]  Cd Length: 218  Bit Score: 40.00  E-value: 6.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365939  46 LSLHTGFIENCNGSALVEarsLGHqTSLITAVYGP--------RSIRGSFTSQGTISIQLKNGLLEKYNTNELKEVSSFL 117
Cdd:cd11358    4 VEIETGVLNQADGSALVK---LGN-TKVICAVTGPivepdkleRPDKGTLYVNVEISPGAVGERRQGPPGDEEMEISRLL 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 398365939 118 MGIFNSVVNLS---RYPKSGIDIFVYLTydkdltnnpqDDDSqskmmssqisSLIPHCITSITLALADAGIELV 188
Cdd:cd11358   80 ERTIEASVILDkstRKPSWVLYVDIQVL----------SRDG----------GLLDACWNAAIAALKDAGIPRV 133
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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