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Conserved domains on  [gi|6321769|ref|NP_011845|]
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4a-hydroxytetrahydrobiopterin dehydratase [Saccharomyces cerevisiae S288C]

Protein Classification

4a-hydroxytetrahydrobiopterin dehydratase( domain architecture ID 10473857)

4a-hydroxytetrahydrobiopterin dehydratase catalyzes the conversion from (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin to (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin in tetrahydrobiopterin biosynthesis

CATH:  3.30.1360.20
EC:  4.2.1.96
Gene Ontology:  GO:0008124|GO:0006729
PubMed:  10727395|8590013
SCOP:  4001463

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pterin_4a pfam01329
Pterin 4 alpha carbinolamine dehydratase; Pterin 4 alpha carbinolamine dehydratase is also ...
 13-113 7.31e-23

Pterin 4 alpha carbinolamine dehydratase; Pterin 4 alpha carbinolamine dehydratase is also known as DCoH (dimerization cofactor of hepatocyte nuclear factor 1-alpha).


:

Pssm-ID: 460161  Cd Length: 88  Bit Score: 84.83  E-value: 7.31e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321769     13 LTGGKLLEKLKPLTRWEVQwdpnktKCLGITREVTFKDYETTWAFLTRVSMRSHLWGHHPLIHTSYTWVKLELHTHDIDp 92
Cdd:pfam01329   1 LTEEEIEAALAELPGWKLG------DGGALERTFKFKDFKEAIAFVNRVALLAEAEGHHPDITNVYNKVTVTLTTHDAG- 73

                          90       100
                  ....*....|....*....|.
gi 6321769     93 kdgahsQLSDIDVRMAKRIDS 113
Cdd:pfam01329  74 ------GLTENDFILAAKIDE 88
 
Name Accession Description Interval E-value
Pterin_4a pfam01329
Pterin 4 alpha carbinolamine dehydratase; Pterin 4 alpha carbinolamine dehydratase is also ...
 13-113 7.31e-23

Pterin 4 alpha carbinolamine dehydratase; Pterin 4 alpha carbinolamine dehydratase is also known as DCoH (dimerization cofactor of hepatocyte nuclear factor 1-alpha).


Pssm-ID: 460161  Cd Length: 88  Bit Score: 84.83  E-value: 7.31e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321769     13 LTGGKLLEKLKPLTRWEVQwdpnktKCLGITREVTFKDYETTWAFLTRVSMRSHLWGHHPLIHTSYTWVKLELHTHDIDp 92
Cdd:pfam01329   1 LTEEEIEAALAELPGWKLG------DGGALERTFKFKDFKEAIAFVNRVALLAEAEGHHPDITNVYNKVTVTLTTHDAG- 73

                          90       100
                  ....*....|....*....|.
gi 6321769     93 kdgahsQLSDIDVRMAKRIDS 113
Cdd:pfam01329  74 ------GLTENDFILAAKIDE 88
PhhB COG2154
Pterin-4a-carbinolamine dehydratase [Coenzyme transport and metabolism];
9-119 2.58e-20

Pterin-4a-carbinolamine dehydratase [Coenzyme transport and metabolism];


Pssm-ID: 441757  Cd Length: 99  Bit Score: 78.71  E-value: 2.58e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321769    9 ASSALTGGKLLEKLKPLTRWEVQWDpnktkclGITREVTFKDYETTWAFLTRVSMRSHLWGHHPLIHTSYTWVKLELHTH 88
Cdd:COG2154   2 AEPPLTDEEIAAALAELPGWELEDG-------ALERTFKFKDFAEALAFVNRVAELAEAEDHHPDISNRYNRVTVTLTTH 74

                        90       100       110
                ....*....|....*....|....*....|.
gi 6321769   89 DIDpkdgahsQLSDIDVRMAKRIDSYIDEMT 119
Cdd:COG2154  75 DAG-------GLTENDFILAAKIDALAAALG 98
PCD_DCoH cd00488
PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known ...
 28-112 4.40e-20

PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by associating with specific DNA binding proteins such as HNF-1alpha (hepatocyte nuclear factor-1) and Xenopus enhancer of rudimentary homologue (XERH). DCoH also catalyzes the dehydration of 4alpha- hydroxy- tetrahydrobiopterin (4alpha-OH-BH4) to quinoiddihydrobiopterin, a percursor of the phenylalanine hydroxylase cofactor BH4 (tetrahydrobiopterin). The DCoH homodimer has a saddle-shaped structure similar to that of TBP (TATA binding protein). Two DCoH proteins have been identifed in humans: DCoH1 and DCoH2. Mutations in human DCoH1 cause hyperphenylalaninemia. Loss of enzymic activity of DCoH in humans is associated with the depigmentation disorder vitiligo. DCoH1 has been reported to be overexpessed in colon cancer carcinomas and in malignant melanomas.


Pssm-ID: 238272  Cd Length: 75  Bit Score: 77.17  E-value: 4.40e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321769   28 WEVQwDPNKtkclgITREVTFKDYETTWAFLTRVSMRSHLWGHHPLIHTSYTWVKLELHTHDIDpkdgahsQLSDIDVRM 107
Cdd:cd00488   2 WELA-DGDA-----LERTFKFKDFKEAIAFVNRVAELAEALNHHPDISNVYNKVTVTLTTHDAG-------GLTENDFIL 68


                ....*
gi 6321769  108 AKRID 112
Cdd:cd00488  69 AAKID 73
phhB PRK00823
pterin-4-alpha-carbinolamine dehydratase; Validated
 20-113 2.38e-15

pterin-4-alpha-carbinolamine dehydratase; Validated


Pssm-ID: 234845  Cd Length: 97  Bit Score: 66.02  E-value: 2.38e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321769    20 EKLKPLTRWEVQWDPNKtkclgITREVTFKDYETTWAFLTRVSMRSHLWGHHPLIHTSYTWVKLELHTHDIdpkDGahsq 99
Cdd:PRK00823  13 ELLPQLPGWTLVGDRDA-----IERTFKFKNFNEAFAFMNRVAEIAEEEDHHPDWFNVYNRVTVTLTTHDA---GG---- 80

                         90
                 ....*....|....
gi 6321769   100 LSDIDVRMAKRIDS 113
Cdd:PRK00823  81 LTENDFILAAKIDA 94
 
Name Accession Description Interval E-value
Pterin_4a pfam01329
Pterin 4 alpha carbinolamine dehydratase; Pterin 4 alpha carbinolamine dehydratase is also ...
 13-113 7.31e-23

Pterin 4 alpha carbinolamine dehydratase; Pterin 4 alpha carbinolamine dehydratase is also known as DCoH (dimerization cofactor of hepatocyte nuclear factor 1-alpha).


Pssm-ID: 460161  Cd Length: 88  Bit Score: 84.83  E-value: 7.31e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321769     13 LTGGKLLEKLKPLTRWEVQwdpnktKCLGITREVTFKDYETTWAFLTRVSMRSHLWGHHPLIHTSYTWVKLELHTHDIDp 92
Cdd:pfam01329   1 LTEEEIEAALAELPGWKLG------DGGALERTFKFKDFKEAIAFVNRVALLAEAEGHHPDITNVYNKVTVTLTTHDAG- 73

                          90       100
                  ....*....|....*....|.
gi 6321769     93 kdgahsQLSDIDVRMAKRIDS 113
Cdd:pfam01329  74 ------GLTENDFILAAKIDE 88
PhhB COG2154
Pterin-4a-carbinolamine dehydratase [Coenzyme transport and metabolism];
9-119 2.58e-20

Pterin-4a-carbinolamine dehydratase [Coenzyme transport and metabolism];


Pssm-ID: 441757  Cd Length: 99  Bit Score: 78.71  E-value: 2.58e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321769    9 ASSALTGGKLLEKLKPLTRWEVQWDpnktkclGITREVTFKDYETTWAFLTRVSMRSHLWGHHPLIHTSYTWVKLELHTH 88
Cdd:COG2154   2 AEPPLTDEEIAAALAELPGWELEDG-------ALERTFKFKDFAEALAFVNRVAELAEAEDHHPDISNRYNRVTVTLTTH 74

                        90       100       110
                ....*....|....*....|....*....|.
gi 6321769   89 DIDpkdgahsQLSDIDVRMAKRIDSYIDEMT 119
Cdd:COG2154  75 DAG-------GLTENDFILAAKIDALAAALG 98
PCD_DCoH cd00488
PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known ...
 28-112 4.40e-20

PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by associating with specific DNA binding proteins such as HNF-1alpha (hepatocyte nuclear factor-1) and Xenopus enhancer of rudimentary homologue (XERH). DCoH also catalyzes the dehydration of 4alpha- hydroxy- tetrahydrobiopterin (4alpha-OH-BH4) to quinoiddihydrobiopterin, a percursor of the phenylalanine hydroxylase cofactor BH4 (tetrahydrobiopterin). The DCoH homodimer has a saddle-shaped structure similar to that of TBP (TATA binding protein). Two DCoH proteins have been identifed in humans: DCoH1 and DCoH2. Mutations in human DCoH1 cause hyperphenylalaninemia. Loss of enzymic activity of DCoH in humans is associated with the depigmentation disorder vitiligo. DCoH1 has been reported to be overexpessed in colon cancer carcinomas and in malignant melanomas.


Pssm-ID: 238272  Cd Length: 75  Bit Score: 77.17  E-value: 4.40e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321769   28 WEVQwDPNKtkclgITREVTFKDYETTWAFLTRVSMRSHLWGHHPLIHTSYTWVKLELHTHDIDpkdgahsQLSDIDVRM 107
Cdd:cd00488   2 WELA-DGDA-----LERTFKFKDFKEAIAFVNRVAELAEALNHHPDISNVYNKVTVTLTTHDAG-------GLTENDFIL 68


                ....*
gi 6321769  108 AKRID 112
Cdd:cd00488  69 AAKID 73
phhB PRK00823
pterin-4-alpha-carbinolamine dehydratase; Validated
 20-113 2.38e-15

pterin-4-alpha-carbinolamine dehydratase; Validated


Pssm-ID: 234845  Cd Length: 97  Bit Score: 66.02  E-value: 2.38e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321769    20 EKLKPLTRWEVQWDPNKtkclgITREVTFKDYETTWAFLTRVSMRSHLWGHHPLIHTSYTWVKLELHTHDIdpkDGahsq 99
Cdd:PRK00823  13 ELLPQLPGWTLVGDRDA-----IERTFKFKNFNEAFAFMNRVAEIAEEEDHHPDWFNVYNRVTVTLTTHDA---GG---- 80

                         90
                 ....*....|....
gi 6321769   100 LSDIDVRMAKRIDS 113
Cdd:PRK00823  81 LTENDFILAAKIDA 94
PCD_DCoH_subfamily_a cd00913
PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known ...
 28-112 5.01e-13

PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by associating with specific DNA binding proteins such as HNF-1alpha (hepatocyte nuclear factor-1) and Xenopus enhancer of rudimentary homologue (XERH). DCoH also catalyzes the dehydration of 4alpha- hydroxy- tetrahydrobiopterin (4alpha-OH-BH4) to quinoiddihydrobiopterin, a percursor of the phenylalanine hydroxylase cofactor BH4 (tetrahydrobiopterin). The DCoH homodimer has a saddle-shaped structure similar to that of TBP (TATA binding protein).


Pssm-ID: 238455  Cd Length: 76  Bit Score: 59.55  E-value: 5.01e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321769   28 WEVQWDPNKtkclgITREVTFKDYETTWAFLTRVSMRSHLWGHHPLIHTSYTWVKLELHTHDIDpkdgahsQLSDIDVRM 107
Cdd:cd00913   2 WELADDGLK-----LERTFRFKNFVEALEFVNAVGEIAEAEGHHPDLSLGWGRVRVTWWTHSIG-------GLSENDFIM 69


                ....*
gi 6321769  108 AKRID 112
Cdd:cd00913  70 AAKID 74
PCD_DCoH_subfamily_b cd00914
PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known ...
 28-112 2.89e-11

PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by associating with specific DNA binding proteins such as HNF-1alpha (hepatocyte nuclear factor-1) and Xenopus enhancer of rudimentary homologue (XERH). DCoH also catalyzes the dehydration of 4alpha- hydroxy- tetrahydrobiopterin (4alpha-OH-BH4) to quinoiddihydrobiopterin, a percursor of the phenylalanine hydroxylase cofactor BH4 (tetrahydrobiopterin). The DCoH homodimer has a saddle-shaped structure similar to that of TBP (TATA binding protein). Two DCoH proteins have been identifed in humans: DCoH1 and DCoH2. Mutations in human DCoH1 cause hyperphenylalaninemia. Loss of enzymic activity of DCoH in humans is associated with the depigmentation disorder vitiligo. DCoH1 has been reported to be overexpessed in colon cancer carcinomas and in malignant melanomas.


Pssm-ID: 238456  Cd Length: 76  Bit Score: 54.93  E-value: 2.89e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321769   28 WEVQWDPNKtkclgITREVTFKDYETTWAFLTRVSMRSHLWGHHPLIHTSYTWVKLELHTHDIDpkdgahsQLSDIDVRM 107
Cdd:cd00914   2 WTLVDGRDA-----IHKSFKFKDFNEAFGFMTRVALEAEKMNHHPEWFNVYNKVDITLTTHDAG-------GLTERDIKL 69


                ....*
gi 6321769  108 AKRID 112
Cdd:cd00914  70 AKFIE 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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