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Conserved domains on  [gi|398365005|ref|NP_012067|]
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Rix1p [Saccharomyces cerevisiae S288C]

Protein Classification

RIX1/PELP1 family protein( domain architecture ID 10548307)

RIX1/PELP1 family protein similar to fungal pre-rRNA-processing protein RIX1 which is a component of the RIX1 RNA processing complex that is involved in ribosome biogenesis, DNA replication and in heterochromatic gene silencing

Gene Ontology:  GO:0006364|GO:0005654|GO:0003682
PubMed:  22421151

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RIX1 pfam08167
rRNA processing/ribosome biogenesis; Rix1 is a nucleoplasmic particle involved in rRNA ...
 8-201 2.94e-57

rRNA processing/ribosome biogenesis; Rix1 is a nucleoplasmic particle involved in rRNA processing/ribosome assembly. It associates with two other proteins, Ipi1 and Ipi3, to form the RIX1 complex that allows Rea1 - the AAA ATPase - to associate with the 60S ribosomal subunit. More than 170 assembly factors are involved in the construction and maturation of yeast ribosomes, and after these factors have completed their function they need to be released from the pre-ribosomes. Rea1 induces the release of the assembly protein complex in a mechanical fashion. This family is usually associated with NUC202, pfam08166.


:

Pssm-ID: 429855  Cd Length: 183  Bit Score: 193.17  E-value: 2.94e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365005    8 VSTLARNLEIAKGNEFHTILATLRSPVYINEQLLKSELSFLVTKILKLIRSGNDFDLWKGCHTSVVTCAYNPLVLSTHGG 87
Cdd:pfam08167   1 LRVLLNRLSSTPPKELPTILPTLASHGLLCEELLKSELDHLVTRILSLLQSKSPEGRWAGVCLAKVTVEYSPWELLSHGS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365005   88 QLLAAIYSRLEQKtgfySSVISsshgkqlFNTLISSVAIIIDLMKNKPTLSREALVPKLKAIIPTLITLSQYEPELVLPV 167
Cdd:pfam08167  81 TWLRALLSILEKP----DPPAT-------LELAIITLTRIFTLTRGKPTLTREILTPNLPTFITALLQLLEELPETVLDA 149

                         170       180       190
                  ....*....|....*....|....*....|....
gi 398365005  168 LQRILKRNTTTFKPFTNKFRTVLINLIISDYASL 201
Cdd:pfam08167 150 LSTLLPLHPTTFRPFANKIRSLLLSLLASSSSSP 183
 
Name Accession Description Interval E-value
RIX1 pfam08167
rRNA processing/ribosome biogenesis; Rix1 is a nucleoplasmic particle involved in rRNA ...
 8-201 2.94e-57

rRNA processing/ribosome biogenesis; Rix1 is a nucleoplasmic particle involved in rRNA processing/ribosome assembly. It associates with two other proteins, Ipi1 and Ipi3, to form the RIX1 complex that allows Rea1 - the AAA ATPase - to associate with the 60S ribosomal subunit. More than 170 assembly factors are involved in the construction and maturation of yeast ribosomes, and after these factors have completed their function they need to be released from the pre-ribosomes. Rea1 induces the release of the assembly protein complex in a mechanical fashion. This family is usually associated with NUC202, pfam08166.


Pssm-ID: 429855  Cd Length: 183  Bit Score: 193.17  E-value: 2.94e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365005    8 VSTLARNLEIAKGNEFHTILATLRSPVYINEQLLKSELSFLVTKILKLIRSGNDFDLWKGCHTSVVTCAYNPLVLSTHGG 87
Cdd:pfam08167   1 LRVLLNRLSSTPPKELPTILPTLASHGLLCEELLKSELDHLVTRILSLLQSKSPEGRWAGVCLAKVTVEYSPWELLSHGS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365005   88 QLLAAIYSRLEQKtgfySSVISsshgkqlFNTLISSVAIIIDLMKNKPTLSREALVPKLKAIIPTLITLSQYEPELVLPV 167
Cdd:pfam08167  81 TWLRALLSILEKP----DPPAT-------LELAIITLTRIFTLTRGKPTLTREILTPNLPTFITALLQLLEELPETVLDA 149

                         170       180       190
                  ....*....|....*....|....*....|....
gi 398365005  168 LQRILKRNTTTFKPFTNKFRTVLINLIISDYASL 201
Cdd:pfam08167 150 LSTLLPLHPTTFRPFANKIRSLLLSLLASSSSSP 183
 
Name Accession Description Interval E-value
RIX1 pfam08167
rRNA processing/ribosome biogenesis; Rix1 is a nucleoplasmic particle involved in rRNA ...
 8-201 2.94e-57

rRNA processing/ribosome biogenesis; Rix1 is a nucleoplasmic particle involved in rRNA processing/ribosome assembly. It associates with two other proteins, Ipi1 and Ipi3, to form the RIX1 complex that allows Rea1 - the AAA ATPase - to associate with the 60S ribosomal subunit. More than 170 assembly factors are involved in the construction and maturation of yeast ribosomes, and after these factors have completed their function they need to be released from the pre-ribosomes. Rea1 induces the release of the assembly protein complex in a mechanical fashion. This family is usually associated with NUC202, pfam08166.


Pssm-ID: 429855  Cd Length: 183  Bit Score: 193.17  E-value: 2.94e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365005    8 VSTLARNLEIAKGNEFHTILATLRSPVYINEQLLKSELSFLVTKILKLIRSGNDFDLWKGCHTSVVTCAYNPLVLSTHGG 87
Cdd:pfam08167   1 LRVLLNRLSSTPPKELPTILPTLASHGLLCEELLKSELDHLVTRILSLLQSKSPEGRWAGVCLAKVTVEYSPWELLSHGS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365005   88 QLLAAIYSRLEQKtgfySSVISsshgkqlFNTLISSVAIIIDLMKNKPTLSREALVPKLKAIIPTLITLSQYEPELVLPV 167
Cdd:pfam08167  81 TWLRALLSILEKP----DPPAT-------LELAIITLTRIFTLTRGKPTLTREILTPNLPTFITALLQLLEELPETVLDA 149

                         170       180       190
                  ....*....|....*....|....*....|....
gi 398365005  168 LQRILKRNTTTFKPFTNKFRTVLINLIISDYASL 201
Cdd:pfam08167 150 LSTLLPLHPTTFRPFANKIRSLLLSLLASSSSSP 183
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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