|
Name |
Accession |
Description |
Interval |
E-value |
| DEADc_DDX31 |
cd17949 |
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ... |
154-373 |
1.23e-115 |
|
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350707 [Multi-domain] Cd Length: 214 Bit Score: 347.27 E-value: 1.23e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 154 LVSHLEQKMRIKKPTSIQKQAIPQIIGnagKNDFFIHAQTGSGKTLSYLLPIISTILNMDTHVDRTSGAFALVIAPTREL 233
Cdd:cd17949 1 LVSHLKSKMGIEKPTAIQKLAIPVLLQ---GRDVLVRSQTGSGKTLAYLLPIIQRLLSLEPRVDRSDGTLALVLVPTREL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 234 ASQIYHVCSTLVSCCHYLVPCLLIGGERKKSEKARLRKGCNFIIGTPGRVLDHLQNTKVIKeqlSQSLRYIVLDEGDKLM 313
Cdd:cd17949 78 ALQIYEVLEKLLKPFHWIVPGYLIGGEKRKSEKARLRKGVNILIATPGRLLDHLKNTQSFD---VSNLRWLVLDEADRLL 154
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 314 ELGFDETISEIIKIVHDIPINSEKFPKLPHKLVHMLCSATLTDGVNRLRNVALKDYKLIS 373
Cdd:cd17949 155 DMGFEKDITKILELLDDKRSKAGGEKSKPSRRQTVLVSATLTDGVKRLAGLSLKDPVYID 214
|
|
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
145-626 |
5.82e-82 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 267.01 E-value: 5.82e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 145 FASLGVSSLLVSHLEqKMRIKKPTSIQKQAIPQIIgnAGKnDFFIHAQTGSGKTLSYLLPIISTILNmdthvDRTSGAFA 224
Cdd:COG0513 4 FADLGLSPPLLKALA-ELGYTTPTPIQAQAIPLIL--AGR-DVLGQAQTGTGKTAAFLLPLLQRLDP-----SRPRAPQA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 225 LVIAPTRELASQIYHVCSTLVSCCHYLVpCLLIGGERKKSEKARLRKGCNFIIGTPGRVLDHLQNtKVIKeqLSQsLRYI 304
Cdd:COG0513 75 LILAPTRELALQVAEELRKLAKYLGLRV-ATVYGGVSIGRQIRALKRGVDIVVATPGRLLDLIER-GALD--LSG-VETL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 305 VLDEGDKLMELGFDETISEIIKivhdipinsekfpKLPHKLVHMLCSATLTDGVNRLRNVALKDYKLISNGTKkdsdivT 384
Cdd:COG0513 150 VLDEADRMLDMGFIEDIERILK-------------LLPKERQTLLFSATMPPEIRKLAKRYLKNPVRIEVAPE------N 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 385 VAPDQLLQRITIVPPKLRLVTLAATLNNITKDfiasgqqsktlRTIVFVSCSDSVEfhydafsgsdghhkNLTGdsvRLL 464
Cdd:COG0513 211 ATAETIEQRYYLVDKRDKLELLRRLLRDEDPE-----------RAIVFCNTKRGAD--------------RLAE---KLQ 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 465 TKGntmFPCFSdsrdpdvviykLHGSLSQQMRTSTLQHFardneaTKGKHLIMFCTDVASRGLDLPHVGSVIELDPPFAV 544
Cdd:COG0513 263 KRG---ISAAA-----------LHGDLSQGQRERALDAF------RNGKIRVLVATDVAARGIDIDDVSHVINYDLPEDP 322
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 545 EDHLHRVGRTARAGEKGESLLFLLPgEEEKYMDYIQPYhpMGwelLKFDKEILmPAFKDVNVNRNDKFIRKDEKSSKNKD 624
Cdd:COG0513 323 EDYVHRIGRTGRAGAEGTAISLVTP-DERRLLRAIEKL--IG---QKIEEEEL-PGFEPVEEKRLERLKPKIKEKLKGKK 395
|
..
gi 6322876 625 VG 626
Cdd:COG0513 396 AG 397
|
|
| DEADc |
cd00268 |
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ... |
154-373 |
2.10e-59 |
|
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350669 [Multi-domain] Cd Length: 196 Bit Score: 199.21 E-value: 2.10e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 154 LVSHLEqKMRIKKPTSIQKQAIPQIIgnAGKnDFFIHAQTGSGKTLSYLLPIISTILNMDThvDRTSGAFALVIAPTREL 233
Cdd:cd00268 1 LLKALK-KLGFEKPTPIQAQAIPLIL--SGR-DVIGQAQTGSGKTLAFLLPILEKLLPEPK--KKGRGPQALVLAPTREL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 234 ASQIYHVCSTLVSCCHyLVPCLLIGGERKKSEKARLRKGCNFIIGTPGRVLDHLQNTKVikeQLSQsLRYIVLDEGDKLM 313
Cdd:cd00268 75 AMQIAEVARKLGKGTG-LKVAAIYGGAPIKKQIEALKKGPDIVVGTPGRLLDLIERGKL---DLSN-VKYLVLDEADRML 149
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 314 ELGFDETISEIIKivhdipinsekfpKLPHKLVHMLCSATLTDGVNRLRNVALKDYKLIS 373
Cdd:cd00268 150 DMGFEEDVEKILS-------------ALPKDRQTLLFSATLPEEVKELAKKFLKNPVRIE 196
|
|
| DEADc_MSS116 |
cd17964 |
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ... |
150-373 |
2.41e-44 |
|
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350722 [Multi-domain] Cd Length: 211 Bit Score: 158.52 E-value: 2.41e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 150 VSSLLVSHLeQKMRIKKPTSIQKQAIPQIIGNagKNDFFIHAQTGSGKTLSYLLPIISTILNmDTHVDRTSGAFALVIAP 229
Cdd:cd17964 1 LDPSLLKAL-TRMGFETMTPVQQKTLKPILST--GDDVLARAKTGTGKTLAFLLPAIQSLLN-TKPAGRRSGVSALIISP 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 230 TRELASQIYHVCSTLVSCCHYLVPCLLIGGERKKSEKARLRK-GCNFIIGTPGRVLDHLQNTKVIKEqlSQSLRYIVLDE 308
Cdd:cd17964 77 TRELALQIAAEAKKLLQGLRKLRVQSAVGGTSRRAELNRLRRgRPDILVATPGRLIDHLENPGVAKA--FTDLDYLVLDE 154
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6322876 309 GDKLMELGFDETISEIIKIVHdiPINSEKFPKlphklvhMLCSATLTDGVNRLRNVAL-KDYKLIS 373
Cdd:cd17964 155 ADRLLDMGFRPDLEQILRHLP--EKNADPRQT-------LLFSATVPDEVQQIARLTLkKDYKFID 211
|
|
| DEADc_DDX3_DDX4 |
cd17967 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ... |
144-369 |
1.25e-43 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350725 [Multi-domain] Cd Length: 221 Bit Score: 156.88 E-value: 1.25e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 144 QFASLGVSSLLVSHLeQKMRIKKPTSIQKQAIPqiIGNAGKnDFFIHAQTGSGKTLSYLLPIISTILN----MDTHVDRT 219
Cdd:cd17967 1 SFEEAGLRELLLENI-KRAGYTKPTPVQKYAIP--IILAGR-DLMACAQTGSGKTAAFLLPIISKLLEdgppSVGRGRRK 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 220 SGAFALVIAPTRELASQIYHV------CSTLVSCCHYlvpclliGGERKKSEKARLRKGCNFIIGTPGRVLDHLQNTKVi 293
Cdd:cd17967 77 AYPSALILAPTRELAIQIYEEarkfsyRSGVRSVVVY-------GGADVVHQQLQLLRGCDILVATPGRLVDFIERGRI- 148
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6322876 294 keQLSqSLRYIVLDEGDKLMELGFdetISEIIKIVHDipinsekfPKLPHKLVH--MLCSATLTDGVNRLRNVALKDY 369
Cdd:cd17967 149 --SLS-SIKFLVLDEADRMLDMGF---EPQIRKIVEH--------PDMPPKGERqtLMFSATFPREIQRLAADFLKNY 212
|
|
| DEADc_DDX47 |
cd17954 |
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ... |
144-368 |
1.29e-43 |
|
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350712 [Multi-domain] Cd Length: 203 Bit Score: 156.32 E-value: 1.29e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 144 QFASLGVSSLLVSHLEqKMRIKKPTSIQKQAIP------QIIGnagkndffiHAQTGSGKTLSYLLPIISTILNmdthvd 217
Cdd:cd17954 1 TFKELGVCEELCEACE-KLGWKKPTKIQEEAIPvalqgrDIIG---------LAETGSGKTAAFALPILQALLE------ 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 218 RTSGAFALVIAPTRELASQIYHVCSTLVSCCHyLVPCLLIGGERKKSEKARLRKGCNFIIGTPGRVLDHLQNTKVIKeql 297
Cdd:cd17954 65 NPQRFFALVLAPTRELAQQISEQFEALGSSIG-LKSAVLVGGMDMMAQAIALAKKPHVIVATPGRLVDHLENTKGFS--- 140
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6322876 298 SQSLRYIVLDEGDKLMELGFDETISEIIKIvhdipinsekfpkLPHKLVHMLCSATLTDGVNRLRNVALKD 368
Cdd:cd17954 141 LKSLKFLVMDEADRLLNMDFEPEIDKILKV-------------IPRERTTYLFSATMTTKVAKLQRASLKN 198
|
|
| DEADc_DDX55 |
cd17960 |
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ... |
160-363 |
1.90e-42 |
|
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350718 [Multi-domain] Cd Length: 202 Bit Score: 152.73 E-value: 1.90e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 160 QKMRIKKPTSIQKQAIPQIIGNagkNDFFIHAQTGSGKTLSYLLPIISTILNMDTHVDRTsGAFALVIAPTRELASQIYH 239
Cdd:cd17960 6 AELGFTSMTPVQAATIPLFLSN---KDVVVEAVTGSGKTLAFLIPVLEILLKRKANLKKG-QVGALIISPTRELATQIYE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 240 VCSTLVSCCH-YLVPCLLIGGERKKSE-KARLRKGCNFIIGTPGRVLDHLQNtKVIKEQLSqSLRYIVLDEGDKLMELGF 317
Cdd:cd17960 82 VLQSFLEHHLpKLKCQLLIGGTNVEEDvKKFKRNGPNILVGTPGRLEELLSR-KADKVKVK-SLEVLVLDEADRLLDLGF 159
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 6322876 318 DETISEIIKivhdipinsekfpKLPHKLVHMLCSATLTDGVNRL-----RN 363
Cdd:cd17960 160 EADLNRILS-------------KLPKQRRTGLFSATQTDAVEELikaglRN 197
|
|
| DEADc_DDX27 |
cd17947 |
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ... |
160-367 |
2.55e-42 |
|
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350705 [Multi-domain] Cd Length: 196 Bit Score: 152.41 E-value: 2.55e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 160 QKMRIKKPTSIQKQAIPqiIGNAGKnDFFIHAQTGSGKTLSYLLPIISTILNMDTHVDRTSgafALVIAPTRELASQIYH 239
Cdd:cd17947 6 SSLGFTKPTPIQAAAIP--LALLGK-DICASAVTGSGKTAAFLLPILERLLYRPKKKAATR---VLVLVPTRELAMQCFS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 240 VCSTLVSCCHYLVpCLLIGGERKKSEKARLRKGCNFIIGTPGRVLDHLQNTKVIkeQLSqSLRYIVLDEGDKLMELGFDE 319
Cdd:cd17947 80 VLQQLAQFTDITF-ALAVGGLSLKAQEAALRARPDIVIATPGRLIDHLRNSPSF--DLD-SIEILVLDEADRMLEEGFAD 155
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 6322876 320 TISEIIKivhdipinsekfpKLPHKLVHMLCSATLTDGVNRLRNVALK 367
Cdd:cd17947 156 ELKEILR-------------LCPRTRQTMLFSATMTDEVKDLAKLSLN 190
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
116-569 |
3.42e-42 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 161.48 E-value: 3.42e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 116 REITTavntnIHDENVainpsnaPLKGDQFASLGVSSLLVSHLEQKmRIKKPTSIQKQAIPqiIGNAGKnDFFIHAQTGS 195
Cdd:PTZ00110 115 KEITI-----IAGENV-------PKPVVSFEYTSFPDYILKSLKNA-GFTEPTPIQVQGWP--IALSGR-DMIGIAETGS 178
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 196 GKTLSYLLPIISTIlNMDTHVDRTSGAFALVIAPTRELASQIYHVC------STLVSCCHYlvpclliGGERKKSEKARL 269
Cdd:PTZ00110 179 GKTLAFLLPAIVHI-NAQPLLRYGDGPIVLVLAPTRELAEQIREQCnkfgasSKIRNTVAY-------GGVPKRGQIYAL 250
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 270 RKGCNFIIGTPGRVLDHLqntkvikEQLSQSLR---YIVLDEGDKLMELGFDetiSEIIKIVHDIPIN------SEKFPK 340
Cdd:PTZ00110 251 RRGVEILIACPGRLIDFL-------ESNVTNLRrvtYLVLDEADRMLDMGFE---PQIRKIVSQIRPDrqtlmwSATWPK 320
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 341 LPHKLVHMLCSATLTDgvnrlRNVALKDYKLISNgtkkdsdivtvapdqLLQRITIVPPKLRLVTLAATLNNITKDfias 420
Cdd:PTZ00110 321 EVQSLARDLCKEEPVH-----VNVGSLDLTACHN---------------IKQEVFVVEEHEKRGKLKMLLQRIMRD---- 376
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 421 gqqskTLRTIVFVscsdsvefhyDAFSGSDGHHKNLTGDSVRLLTkgntmfpcfsdsrdpdvviykLHGSLSQQMRTSTL 500
Cdd:PTZ00110 377 -----GDKILIFV----------ETKKGADFLTKELRLDGWPALC---------------------IHGDKKQEERTWVL 420
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6322876 501 qhfardNEATKGKHLIMFCTDVASRGLDLPHVGSVIELDPPFAVEDHLHRVGRTARAGEKGESLLFLLP 569
Cdd:PTZ00110 421 ------NEFKTGKSPIMIATDVASRGLDVKDVKYVINFDFPNQIEDYVHRIGRTGRAGAKGASYTFLTP 483
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
168-361 |
1.71e-41 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 148.93 E-value: 1.71e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 168 TSIQKQAIPQIIgnAGKnDFFIHAQTGSGKTLSYLLPIISTILNMDthvdrtSGAFALVIAPTRELASQIYHVCSTLVSC 247
Cdd:pfam00270 1 TPIQAEAIPAIL--EGR-DVLVQAPTGSGKTLAFLLPALEALDKLD------NGPQALVLAPTRELAEQIYEELKKLGKG 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 248 CHYLVpCLLIGGERKKSEKARLrKGCNFIIGTPGRVLDHLQNTKVIKEqlsqsLRYIVLDEGDKLMELGFDETISEIIKi 327
Cdd:pfam00270 72 LGLKV-ASLLGGDSRKEQLEKL-KGPDILVGTPGRLLDLLQERKLLKN-----LKLLVLDEAHRLLDMGFGPDLEEILR- 143
|
170 180 190
....*....|....*....|....*....|....
gi 6322876 328 vhdipinsekfpKLPHKLVHMLCSATLTDGVNRL 361
Cdd:pfam00270 144 ------------RLPKKRQILLLSATLPRNLEDL 165
|
|
| DEADc_DDX49 |
cd17955 |
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ... |
145-368 |
2.23e-41 |
|
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350713 [Multi-domain] Cd Length: 204 Bit Score: 150.07 E-value: 2.23e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 145 FASLGVSSLLVSHLEQkMRIKKPTSIQKQAIPQIIgnAGKnDFFIHAQTGSGKTLSYLLPIIsTILNMDTHvdrtsGAFA 224
Cdd:cd17955 1 FEDLGLSSWLVKQCAS-LGIKEPTPIQKLCIPEIL--AGR-DVIGGAKTGSGKTAAFALPIL-QRLSEDPY-----GIFA 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 225 LVIAPTRELASQIYHVCSTLVSCCHyLVPCLLIGGERKKSEKARLRKGCNFIIGTPGRVLDHLQNTKVIKEQLSQsLRYI 304
Cdd:cd17955 71 LVLTPTRELAYQIAEQFRALGAPLG-LRCCVIVGGMDMVKQALELSKRPHIVVATPGRLADHLRSSDDTTKVLSR-VKFL 148
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6322876 305 VLDEGDKLMELGFDETISEIIkivhdipinsEKFPKLPHKLvhmLCSATLTDGVNRLRNVALKD 368
Cdd:cd17955 149 VLDEADRLLTGSFEDDLATIL----------SALPPKRQTL---LFSATLTDALKALKELFGNK 199
|
|
| DEADc_DDX18 |
cd17942 |
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ... |
161-367 |
1.02e-40 |
|
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350700 [Multi-domain] Cd Length: 198 Bit Score: 147.89 E-value: 1.02e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 161 KMRIKKPTSIQKQAIPQIIgnAGKnDFFIHAQTGSGKTLSYLLPIIStILNMDTHVDRtSGAFALVIAPTRELASQIYHV 240
Cdd:cd17942 7 EMGFTKMTEIQAKSIPPLL--EGR-DVLGAAKTGSGKTLAFLIPAIE-LLYKLKFKPR-NGTGVIIISPTRELALQIYGV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 241 CSTLvsCCHYLVPC-LLIGGERKKSEKARLRKGCNFIIGTPGRVLDHLQNTkviKEQLSQSLRYIVLDEGDKLMELGFDE 319
Cdd:cd17942 82 AKEL--LKYHSQTFgIVIGGANRKAEAEKLGKGVNILVATPGRLLDHLQNT---KGFLYKNLQCLIIDEADRILEIGFEE 156
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 6322876 320 TISEIIKIvhdipinsekfpkLPHKLVHMLCSATLTDGVNRLRNVALK 367
Cdd:cd17942 157 EMRQIIKL-------------LPKRRQTMLFSATQTRKVEDLARISLK 191
|
|
| PRK11634 |
PRK11634 |
ATP-dependent RNA helicase DeaD; Provisional |
145-567 |
1.73e-38 |
|
ATP-dependent RNA helicase DeaD; Provisional
Pssm-ID: 236941 [Multi-domain] Cd Length: 629 Bit Score: 151.92 E-value: 1.73e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 145 FASLGVSSLLVSHLEQkMRIKKPTSIQKQAIPQIIGNagkNDFFIHAQTGSGKTLSYLLPIIStilNMDTHVDRTSgafA 224
Cdd:PRK11634 8 FADLGLKAPILEALND-LGYEKPSPIQAECIPHLLNG---RDVLGMAQTGSGKTAAFSLPLLH---NLDPELKAPQ---I 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 225 LVIAPTRELASQIYHVCSTLVSCCHYLVPCLLIGGERKKSEKARLRKGCNFIIGTPGRVLDHLQNTKVikeQLSqSLRYI 304
Cdd:PRK11634 78 LVLAPTRELAVQVAEAMTDFSKHMRGVNVVALYGGQRYDVQLRALRQGPQIVVGTPGRLLDHLKRGTL---DLS-KLSGL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 305 VLDEGDKLMELGFdetISEIIKIVHDIPINSEKfpklphklvhMLCSATLTDGVNRLRNVALKDyklisngtkkdsdivt 384
Cdd:PRK11634 154 VLDEADEMLRMGF---IEDVETIMAQIPEGHQT----------ALFSATMPEAIRRITRRFMKE---------------- 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 385 vapdqllqritivPPKLRLVTLAATLNNITKDFIASGQQSKTLRTIVFVSCSDsvefhYDA---FSGSdghhKNLTGDSV 461
Cdd:PRK11634 205 -------------PQEVRIQSSVTTRPDISQSYWTVWGMRKNEALVRFLEAED-----FDAaiiFVRT----KNATLEVA 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 462 RLLTKGNtmfpcFSDSrdpdvviyKLHGSLSQQMRTSTLQHFardneaTKGKHLIMFCTDVASRGLDLPHVGSVIELDPP 541
Cdd:PRK11634 263 EALERNG-----YNSA--------ALNGDMNQALREQTLERL------KDGRLDILIATDVAARGLDVERISLVVNYDIP 323
|
410 420
....*....|....*....|....*.
gi 6322876 542 FAVEDHLHRVGRTARAGEKGESLLFL 567
Cdd:PRK11634 324 MDSESYVHRIGRTGRAGRAGRALLFV 349
|
|
| PRK04837 |
PRK04837 |
ATP-dependent RNA helicase RhlB; Provisional |
145-598 |
1.55e-37 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235314 [Multi-domain] Cd Length: 423 Bit Score: 145.50 E-value: 1.55e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 145 FASLGVSSLLVSHLEQKmRIKKPTSIQKQAIPQIIgnAGKnDFFIHAQTGSGKTLSYLLPIISTILNMDTHVDR-TSGAF 223
Cdd:PRK04837 10 FSDFALHPQVVEALEKK-GFHNCTPIQALALPLTL--AGR-DVAGQAQTGTGKTMAFLTATFHYLLSHPAPEDRkVNQPR 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 224 ALVIAPTRELASQIYHVCSTLVSCCHyLVPCLLIGGERKKSEKARLRKGCNFIIGTPGRVLDHL-QNtkVIkeqlsqSLR 302
Cdd:PRK04837 86 ALIMAPTRELAVQIHADAEPLAQATG-LKLGLAYGGDGYDKQLKVLESGVDILIGTTGRLIDYAkQN--HI------NLG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 303 YI---VLDEGDKLMELGFdetiseiIKivhDIPINSEKFPKLPHKLvHMLCSATLTdgvNRLRNVAlkdYKLISNGTKkd 379
Cdd:PRK04837 157 AIqvvVLDEADRMFDLGF-------IK---DIRWLFRRMPPANQRL-NMLFSATLS---YRVRELA---FEHMNNPEY-- 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 380 sdiVTVAPDQllqritivppklrlvtlaATLNNITKDFIASGQQSK-----TL-------RTIVFVSCSDSVEFHYDAFS 447
Cdd:PRK04837 218 ---VEVEPEQ------------------KTGHRIKEELFYPSNEEKmrllqTLieeewpdRAIIFANTKHRCEEIWGHLA 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 448 GsDGHHknltgdsVRLLTkgntmfpcfsdsrdpdvviyklhGSLSQQMRTSTLQHFardneaTKGKHLIMFCTDVASRGL 527
Cdd:PRK04837 277 A-DGHR-------VGLLT-----------------------GDVAQKKRLRILEEF------TRGDLDILVATDVAARGL 319
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6322876 528 DLPHVGSVIELDPPFAVEDHLHRVGRTARAGEKGESLLFL-------LPGEEEkymdYIQpyHPMgwELLKFDKEILM 598
Cdd:PRK04837 320 HIPAVTHVFNYDLPDDCEDYVHRIGRTGRAGASGHSISLAceeyalnLPAIET----YIG--HSI--PVSKYDSDALL 389
|
|
| DEADc_DDX52 |
cd17957 |
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ... |
164-368 |
1.62e-37 |
|
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350715 [Multi-domain] Cd Length: 198 Bit Score: 138.88 E-value: 1.62e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 164 IKKPTSIQKQAIPQIIGnagKNDFFIHAQTGSGKTLSYLLPIISTILNMDthvdRTSGAFALVIAPTRELASQIYHVCST 243
Cdd:cd17957 10 YREPTPIQMQAIPILLH---GRDLLACAPTGSGKTLAFLIPILQKLGKPR----KKKGLRALILAPTRELASQIYRELLK 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 244 LVSCCHyLVPCLLIGGERKKSE-KARLRKGCNFIIGTPGRVLDHLQNTKVikeQLSqSLRYIVLDEGDKLMELGFDETIS 322
Cdd:cd17957 83 LSKGTG-LRIVLLSKSLEAKAKdGPKSITKYDILVSTPLRLVFLLKQGPI---DLS-SVEYLVLDEADKLFEPGFREQTD 157
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 6322876 323 EIIKIvhdipinsekfpkLPHKLVHMLC-SATLTDGVNRLRNVALKD 368
Cdd:cd17957 158 EILAA-------------CTNPNLQRSLfSATIPSEVEELARSVMKD 191
|
|
| DEADc_DDX10 |
cd17941 |
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ... |
165-373 |
1.75e-37 |
|
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350699 [Multi-domain] Cd Length: 198 Bit Score: 138.58 E-value: 1.75e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 165 KKPTSIQKQAIPQIIgnAGKnDFFIHAQTGSGKTLSYLLPIISTIlnmdtHVDR---TSGAFALVIAPTRELASQIYHVC 241
Cdd:cd17941 11 IKMTEIQRDSIPHAL--QGR-DILGAAKTGSGKTLAFLVPLLEKL-----YRERwtpEDGLGALIISPTRELAMQIFEVL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 242 STlVSCCHYLVPCLLIGGERKKSEKARLrKGCNFIIGTPGRVLDHLQNTKVIKeqlSQSLRYIVLDEGDKLMELGFDETI 321
Cdd:cd17941 83 RK-VGKYHSFSAGLIIGGKDVKEEKERI-NRMNILVCTPGRLLQHMDETPGFD---TSNLQMLVLDEADRILDMGFKETL 157
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 6322876 322 SEIIKivhdipinsekfpKLPHKLVHMLCSATLTDGVNRLRNVALKDYKLIS 373
Cdd:cd17941 158 DAIVE-------------NLPKSRQTLLFSATQTKSVKDLARLSLKNPEYIS 196
|
|
| PRK04537 |
PRK04537 |
ATP-dependent RNA helicase RhlB; Provisional |
136-590 |
3.56e-37 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235307 [Multi-domain] Cd Length: 572 Bit Score: 147.40 E-value: 3.56e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 136 SNAPLKGDQFASLGVSSLLVSHLEqKMRIKKPTSIQKQAIPqiIGNAGKnDFFIHAQTGSGKTLSYLLPIISTILNMDTH 215
Cdd:PRK04537 2 SDKPLTDLTFSSFDLHPALLAGLE-SAGFTRCTPIQALTLP--VALPGG-DVAGQAQTGTGKTLAFLVAVMNRLLSRPAL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 216 VDRT-SGAFALVIAPTRELASQIYHVCSTLVSCCHyLVPCLLIGGERKKSEKARLRKGCNFIIGTPGRVLDHLQNTKVIk 294
Cdd:PRK04537 78 ADRKpEDPRALILAPTRELAIQIHKDAVKFGADLG-LRFALVYGGVDYDKQRELLQQGVDVIIATPGRLIDYVKQHKVV- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 295 eqlsqSLR---YIVLDEGDKLMELGFDETISEIIKivhdipinsekfpKLPHKLVH--MLCSATLTDGVNRLRnvalkdY 369
Cdd:PRK04537 156 -----SLHaceICVLDEADRMFDLGFIKDIRFLLR-------------RMPERGTRqtLLFSATLSHRVLELA------Y 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 370 KLISNGTKKDSDIVTVAPDQLLQRITIVPPKLRLVTLAATLNnitkdfiasgqQSKTLRTIVFVSCSDSVEfhydafsgs 449
Cdd:PRK04537 212 EHMNEPEKLVVETETITAARVRQRIYFPADEEKQTLLLGLLS-----------RSEGARTMVFVNTKAFVE--------- 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 450 dghhknltgDSVRLLTKGNtmfpcfsdsrdpdvviYK---LHGSLSQQMRTSTLQHFardneaTKGKHLIMFCTDVASRG 526
Cdd:PRK04537 272 ---------RVARTLERHG----------------YRvgvLSGDVPQKKRESLLNRF------QKGQLEILVATDVAARG 320
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6322876 527 LDLPHVGSVIELDPPFAVEDHLHRVGRTARAGEKGESLLFL-------LPgEEEKYMDYIQPYHPMGWELL 590
Cdd:PRK04537 321 LHIDGVKYVYNYDLPFDAEDYVHRIGRTARLGEEGDAISFAceryamsLP-DIEAYIEQKIPVEPVTAELL 390
|
|
| DEADc_DDX4 |
cd18052 |
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ... |
109-369 |
3.68e-37 |
|
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350810 [Multi-domain] Cd Length: 264 Bit Score: 140.10 E-value: 3.68e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 109 SSLFtsnREITTAVNTNIHDE-NVAINPSNAPLKGDQFASLGVSSLLVSHLeQKMRIKKPTSIQKQAIPqiIGNAGKnDF 187
Cdd:cd18052 11 DEIF---ATIQTGINFDKYDEiPVEVTGRNPPPAILTFEEANLCETLLKNI-RKAGYEKPTPVQKYAIP--IILAGR-DL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 188 FIHAQTGSGKTLSYLLPIISTILN---MDTHVDRTSGAFALVIAPTRELASQIYHVC-----STLVScchylvPCLLIGG 259
Cdd:cd18052 84 MACAQTGSGKTAAFLLPVLTGMMKeglTASSFSEVQEPQALIVAPTRELANQIFLEArkfsyGTCIR------PVVVYGG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 260 ERKKSEKARLRKGCNFIIGTPGRVLDHLQNTKVikeQLSQsLRYIVLDEGDKLMELGFdetISEIIKIVHDipinsekfP 339
Cdd:cd18052 158 VSVGHQIRQIEKGCHILVATPGRLLDFIGRGKI---SLSK-LKYLILDEADRMLDMGF---GPEIRKLVSE--------P 222
|
250 260 270
....*....|....*....|....*....|...
gi 6322876 340 KLPHKLVH--MLCSATLTDGVNRLRNVALK-DY 369
Cdd:cd18052 223 GMPSKEDRqtLMFSATFPEEIQRLAAEFLKeDY 255
|
|
| DEADc_DDX56 |
cd17961 |
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ... |
160-368 |
6.17e-37 |
|
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350719 [Multi-domain] Cd Length: 206 Bit Score: 137.33 E-value: 6.17e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 160 QKMRIKKPTSIQKQAIPQIIgnAGKnDFFIHAQTGSGKTLSYLLPIISTILNMDTHVDRTSGAFALVIAPTRELASQIYH 239
Cdd:cd17961 10 AKLGWEKPTLIQSKAIPLAL--EGK-DILARARTGSGKTAAYALPIIQKILKAKAESGEEQGTRALILVPTRELAQQVSK 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 240 VCSTLVSCCHYLVPCL-LIGGERKKSEKARLRKGCNFIIGTPGRVLDHLQNTKVikeQLSQSLRYIVLDEGDKLMELGFD 318
Cdd:cd17961 87 VLEQLTAYCRKDVRVVnLSASSSDSVQRALLAEKPDIVVSTPARLLSHLESGSL---LLLSTLKYLVIDEADLVLSYGYE 163
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 6322876 319 ETISEIIKIvhdIPINSEKFpklphklvhmLCSATLTDGVNRLRNVALKD 368
Cdd:cd17961 164 EDLKSLLSY---LPKNYQTF----------LMSATLSEDVEALKKLVLHN 200
|
|
| DEADc_DDX23 |
cd17945 |
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ... |
160-361 |
1.23e-36 |
|
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350703 [Multi-domain] Cd Length: 220 Bit Score: 137.07 E-value: 1.23e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 160 QKMRIKKPTSIQKQAIPqiIGNAGKnDFFIHAQTGSGKTLSYLLPIISTILNMD--THVDRTSGAFALVIAPTRELASQI 237
Cdd:cd17945 6 RKLGYKEPTPIQRQAIP--IGLQNR-DIIGIAETGSGKTAAFLIPLLVYISRLPplDEETKDDGPYALILAPTRELAQQI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 238 YHVCSTLvsCCHYLVPCLLIGGERKKSEKA-RLRKGCNFIIGTPGRVLDHLQNTKVIKEQLSqslrYIVLDEGDKLMELG 316
Cdd:cd17945 83 EEETQKF--AKPLGIRVVSIVGGHSIEEQAfSLRNGCEILIATPGRLLDCLERRLLVLNQCT----YVVLDEADRMIDMG 156
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 6322876 317 FDEtisEIIKIVHDIPINSEK-----------FPKLPHKLVHMLcSATLTDGVNRL 361
Cdd:cd17945 157 FEP---QVTKILDAMPVSNKKpdteeaeklaaSGKHRYRQTMMF-TATMPPAVEKI 208
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
161-382 |
1.02e-35 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 133.77 E-value: 1.02e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 161 KMRIKKPTSIQKQAIPQIIgnAGKNDFFIHAQTGSGKTLSYLLPIIstilnmdTHVDRTSGAFALVIAPTRELASQIYHV 240
Cdd:smart00487 3 KFGFEPLRPYQKEAIEALL--SGLRDVILAAPTGSGKTLAALLPAL-------EALKRGKGGRVLVLVPTRELAEQWAEE 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 241 CSTLVSCCHyLVPCLLIGGERKKSEKARLRKGC-NFIIGTPGRVLDHLQNTKVIKEQLSqslrYIVLDEGDKLMELGFDE 319
Cdd:smart00487 74 LKKLGPSLG-LKVVGLYGGDSKREQLRKLESGKtDILVTTPGRLLDLLENDKLSLSNVD----LVILDEAHRLLDGGFGD 148
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6322876 320 TISEIIKivhdipinsekfpKLPHKLVHMLCSATLTDGVNRLRNVALKDYKLISNGTKKDSDI 382
Cdd:smart00487 149 QLEKLLK-------------LLPKNVQLLLLSATPPEEIENLLELFLNDPVFIDVGFTPLEPI 198
|
|
| PLN00206 |
PLN00206 |
DEAD-box ATP-dependent RNA helicase; Provisional |
144-574 |
2.87e-35 |
|
DEAD-box ATP-dependent RNA helicase; Provisional
Pssm-ID: 215103 [Multi-domain] Cd Length: 518 Bit Score: 140.69 E-value: 2.87e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 144 QFASLGVSSLLVSHLEQkMRIKKPTSIQKQAIPQIIgnAGKnDFFIHAQTGSGKTLSYLLPIISTILNMDT-HVDRTSGA 222
Cdd:PLN00206 122 SFSSCGLPPKLLLNLET-AGYEFPTPIQMQAIPAAL--SGR-SLLVSADTGSGKTASFLVPIISRCCTIRSgHPSEQRNP 197
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 223 FALVIAPTRELASQIYHVCSTLVSCCHYLVpCLLIGGERKKSEKARLRKGCNFIIGTPGRVLDHLQNTKVIKEQLSqslr 302
Cdd:PLN00206 198 LAMVLTPTRELCVQVEDQAKVLGKGLPFKT-ALVVGGDAMPQQLYRIQQGVELIVGTPGRLIDLLSKHDIELDNVS---- 272
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 303 YIVLDEGDKLMELGFDETISEIikivhdipinsekFPKLPHKLVhMLCSATLTDGVNRLRNVALKDYKLISNGTKKdsdi 382
Cdd:PLN00206 273 VLVLDEVDCMLERGFRDQVMQI-------------FQALSQPQV-LLFSATVSPEVEKFASSLAKDIILISIGNPN---- 334
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 383 vtvAPDQLLQRITI-VPPKlrlvtlaatlNNITKDF-IASGQQSKTLRTIVFVSCSdsvefhydafSGSDghhknLTGDS 460
Cdd:PLN00206 335 ---RPNKAVKQLAIwVETK----------QKKQKLFdILKSKQHFKPPAVVFVSSR----------LGAD-----LLANA 386
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 461 VRLLTKgntmFPCFSdsrdpdvviykLHGSLSQQMRTSTLQHFardneaTKGKHLIMFCTDVASRGLDLPHVGSVIELDP 540
Cdd:PLN00206 387 ITVVTG----LKALS-----------IHGEKSMKERREVMKSF------LVGEVPVIVATGVLGRGVDLLRVRQVIIFDM 445
|
410 420 430
....*....|....*....|....*....|....
gi 6322876 541 PFAVEDHLHRVGRTARAGEKGESLLFLlpGEEEK 574
Cdd:PLN00206 446 PNTIKEYIHQIGRASRMGEKGTAIVFV--NEEDR 477
|
|
| DEADc_DDX54 |
cd17959 |
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ... |
145-372 |
2.01e-34 |
|
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350717 [Multi-domain] Cd Length: 205 Bit Score: 130.50 E-value: 2.01e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 145 FASLGVSSLLVSHLEqKMRIKKPTSIQKQAIPQIIgnAGKnDFFIHAQTGSGKTLSYLLPIISTILNMDThvdrTSGAFA 224
Cdd:cd17959 3 FQSMGLSPPLLRAIK-KKGYKVPTPIQRKTIPLIL--DGR-DVVAMARTGSGKTAAFLIPMIEKLKAHSP----TVGARA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 225 LVIAPTRELASQIYHVCSTLvSCCHYLVPCLLIGGERKKSEKARLRKGCNFIIGTPGRVLDHLQNTKVikeQLSqSLRYI 304
Cdd:cd17959 75 LILSPTRELALQTLKVTKEL-GKFTDLRTALLVGGDSLEEQFEALASNPDIIIATPGRLLHLLVEMNL---KLS-SVEYV 149
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6322876 305 VLDEGDKLMELGFDETISEIIKivhdipinsekfpKLPHKLVHMLCSATLTDGVNRLRNVALKDYKLI 372
Cdd:cd17959 150 VFDEADRLFEMGFAEQLHEILS-------------RLPENRQTLLFSATLPKLLVEFAKAGLNEPVLI 204
|
|
| DEADc_DDX41 |
cd17951 |
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ... |
160-324 |
1.78e-33 |
|
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350709 [Multi-domain] Cd Length: 206 Bit Score: 127.84 E-value: 1.78e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 160 QKMRIKKPTSIQKQAIPQIIgnAGKNDFFIhAQTGSGKTLSYLLPIISTILN--MDTHVDRTSGAFALVIAPTRELASQI 237
Cdd:cd17951 6 KKKGIKKPTPIQMQGLPTIL--SGRDMIGI-AFTGSGKTLVFTLPLIMFALEqeKKLPFIKGEGPYGLIVCPSRELARQT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 238 Y----HVCSTLVSCCHYLVPCLL-IGGERKKSEKARLRKGCNFIIGTPGRVLDHLqNTKVIKEQLSqslRYIVLDEGDKL 312
Cdd:cd17951 83 HevieYYCKALQEGGYPQLRCLLcIGGMSVKEQLEVIRKGVHIVVATPGRLMDML-NKKKINLDIC---RYLCLDEADRM 158
|
170
....*....|..
gi 6322876 313 MELGFDETISEI 324
Cdd:cd17951 159 IDMGFEEDIRTI 170
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
390-567 |
2.54e-33 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 124.54 E-value: 2.54e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 390 LLQRITIVPPKLRLVTLAATLNNITKDFiasgqqsktlRTIVFVSCSDSVEFHYDAFSGSDghhknltgdsvrlltkgnt 469
Cdd:cd18787 1 IKQLYVVVEEEEKKLLLLLLLLEKLKPG----------KAIIFVNTKKRVDRLAELLEELG------------------- 51
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 470 mFPCFSdsrdpdvviykLHGSLSQQMRTSTLQHFardneaTKGKHLIMFCTDVASRGLDLPHVGSVIELDPPFAVEDHLH 549
Cdd:cd18787 52 -IKVAA-----------LHGDLSQEERERALKKF------RSGKVRVLVATDVAARGLDIPGVDHVINYDLPRDAEDYVH 113
|
170
....*....|....*...
gi 6322876 550 RVGRTARAGEKGESLLFL 567
Cdd:cd18787 114 RIGRTGRAGRKGTAITFV 131
|
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
168-575 |
3.21e-33 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 133.88 E-value: 3.21e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 168 TSIQKQAIPQIIgnAGKnDFFIHAQTGSGKTLSYLLPIISTILNMDTHVDRTSG-AFALVIAPTRELASQIYHVCSTLVS 246
Cdd:PRK01297 111 TPIQAQVLGYTL--AGH-DAIGRAQTGTGKTAAFLISIINQLLQTPPPKERYMGePRALIIAPTRELVVQIAKDAAALTK 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 247 CCHYLVPCLLIGGERKKSEKARLRKGCNFIIGTPGRVLDHLQNTKVIKEQlsqsLRYIVLDEGDKLMELGFdetISEIIK 326
Cdd:PRK01297 188 YTGLNVMTFVGGMDFDKQLKQLEARFCDILVATPGRLLDFNQRGEVHLDM----VEVMVLDEADRMLDMGF---IPQVRQ 260
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 327 IVHDIPINSEKfpklphklVHMLCSATLTDGVNRLRNVALKDYKLIsngtkkDSDIVTVAPDQLLQRITIVP--PKLRLV 404
Cdd:PRK01297 261 IIRQTPRKEER--------QTLLFSATFTDDVMNLAKQWTTDPAIV------EIEPENVASDTVEQHVYAVAgsDKYKLL 326
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 405 TLAATLNNITkdfiasgqqsktlRTIVFVSCSDSVEFHYDafsgsdghhkNLTGDSVRlltkgntmfpcfsdsrdpdvvI 484
Cdd:PRK01297 327 YNLVTQNPWE-------------RVMVFANRKDEVRRIEE----------RLVKDGIN---------------------A 362
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 485 YKLHGSLSQQMRTSTLQHFardneaTKGKHLIMFCTDVASRGLDLPHVGSVIELDPPFAVEDHLHRVGRTARAGEKGESL 564
Cdd:PRK01297 363 AQLSGDVPQHKRIKTLEGF------REGKIRVLVATDVAGRGIHIDGISHVINFTLPEDPDDYVHRIGRTGRAGASGVSI 436
|
410
....*....|.
gi 6322876 565 LFLlpGEEEKY 575
Cdd:PRK01297 437 SFA--GEDDAF 445
|
|
| PRK10590 |
PRK10590 |
ATP-dependent RNA helicase RhlE; Provisional |
145-564 |
3.98e-33 |
|
ATP-dependent RNA helicase RhlE; Provisional
Pssm-ID: 236722 [Multi-domain] Cd Length: 456 Bit Score: 133.39 E-value: 3.98e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 145 FASLGVSS-LLVSHLEQKMRikKPTSIQKQAIPQIIgnAGKnDFFIHAQTGSGKTLSYLLPIISTILNMDTHVDRTSGAF 223
Cdd:PRK10590 3 FDSLGLSPdILRAVAEQGYR--EPTPIQQQAIPAVL--EGR-DLMASAQTGTGKTAGFTLPLLQHLITRQPHAKGRRPVR 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 224 ALVIAPTRELASQI---------YHVCSTLVscchylvpclLIGGERKKSEKARLRKGCNFIIGTPGRVLDhLQNTKVIK 294
Cdd:PRK10590 78 ALILTPTRELAAQIgenvrdyskYLNIRSLV----------VFGGVSINPQMMKLRGGVDVLVATPGRLLD-LEHQNAVK 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 295 eqLSQsLRYIVLDEGDKLMELGFdetiseiikiVHDIpinSEKFPKLPHKLVHMLCSATLTDGVNRLRNvalkdyKLISN 374
Cdd:PRK10590 147 --LDQ-VEILVLDEADRMLDMGF----------IHDI---RRVLAKLPAKRQNLLFSATFSDDIKALAE------KLLHN 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 375 GTKKDSDIVTVAPDQLLQRITIVPPKLRLVTLAatlnnitkDFIASGQQSKTLrtiVFVSCSdsvefhydafSGSDGHHK 454
Cdd:PRK10590 205 PLEIEVARRNTASEQVTQHVHFVDKKRKRELLS--------QMIGKGNWQQVL---VFTRTK----------HGANHLAE 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 455 NLTGDSVRLLTkgntmfpcfsdsrdpdvviykLHGSLSQQMRTSTLQHFardneaTKGKHLIMFCTDVASRGLD---LPH 531
Cdd:PRK10590 264 QLNKDGIRSAA---------------------IHGNKSQGARTRALADF------KSGDIRVLVATDIAARGLDieeLPH 316
|
410 420 430
....*....|....*....|....*....|...
gi 6322876 532 vgsVIELDPPFAVEDHLHRVGRTARAGEKGESL 564
Cdd:PRK10590 317 ---VVNYELPNVPEDYVHRIGRTGRAAATGEAL 346
|
|
| PRK11776 |
PRK11776 |
ATP-dependent RNA helicase DbpA; Provisional |
145-574 |
1.50e-32 |
|
ATP-dependent RNA helicase DbpA; Provisional
Pssm-ID: 236977 [Multi-domain] Cd Length: 460 Bit Score: 131.46 E-value: 1.50e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 145 FASLGVSSLLVSHLEQ----KMrikkpTSIQKQAIPQIIgnAGKnDFFIHAQTGSGKTLSYLLPIIStilNMDTHVDRTS 220
Cdd:PRK11776 6 FSTLPLPPALLANLNElgytEM-----TPIQAQSLPAIL--AGK-DVIAQAKTGSGKTAAFGLGLLQ---KLDVKRFRVQ 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 221 gafALVIAPTRELASQIYHVCSTLVSCCHYLVPCLLIGGERKKSEKARLRKGCNFIIGTPGRVLDHLQntkviKEQLS-Q 299
Cdd:PRK11776 75 ---ALVLCPTRELADQVAKEIRRLARFIPNIKVLTLCGGVPMGPQIDSLEHGAHIIVGTPGRILDHLR-----KGTLDlD 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 300 SLRYIVLDEGDKLMELGFDETISEIIKivhdipinsekfpKLPHKLVHMLCSATLTDGVNRLRNVALKDYKLIS-NGTKK 378
Cdd:PRK11776 147 ALNTLVLDEADRMLDMGFQDAIDAIIR-------------QAPARRQTLLFSATYPEGIAAISQRFQRDPVEVKvESTHD 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 379 DSDIVtvapdqllQRITIVPPKLRLVTLAATLNnitkdfiasgqQSKTLRTIVFvsCSDsvefhydafsgsdghhKNLTG 458
Cdd:PRK11776 214 LPAIE--------QRFYEVSPDERLPALQRLLL-----------HHQPESCVVF--CNT----------------KKECQ 256
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 459 DSVRLLT-KGntmfpcFSdsrdpdvVIyKLHGSLSQQMRTSTLQHFArdNeatkGKHLIMFCTDVASRGLDLPHVGSVIE 537
Cdd:PRK11776 257 EVADALNaQG------FS-------AL-ALHGDLEQRDRDQVLVRFA--N----RSCSVLVATDVAARGLDIKALEAVIN 316
|
410 420 430
....*....|....*....|....*....|....*..
gi 6322876 538 LDPPFAVEDHLHRVGRTARAGEKGESLLFLLPGEEEK 574
Cdd:PRK11776 317 YELARDPEVHVHRIGRTGRAGSKGLALSLVAPEEMQR 353
|
|
| DEADc_DDX3 |
cd18051 |
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ... |
136-325 |
3.60e-32 |
|
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350809 [Multi-domain] Cd Length: 249 Bit Score: 125.15 E-value: 3.60e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 136 SNAPLKGDQFASLGVSSLLVSHLEQKmRIKKPTSIQKQAIPQIIGnagKNDFFIHAQTGSGKTLSYLLPIISTILNMDTH 215
Cdd:cd18051 14 ENCPPHIETFSDLDLGEIIRNNIELA-RYTKPTPVQKHAIPIIKS---KRDLMACAQTGSGKTAAFLLPILSQIYEQGPG 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 216 VDRTSGA----------FALVIAPTRELASQIYHVCSTLVSCCHyLVPCLLIGGERKKSEKARLRKGCNFIIGTPGRVLD 285
Cdd:cd18051 90 ESLPSESgyygrrkqypLALVLAPTRELASQIYDEARKFAYRSR-VRPCVVYGGADIGQQMRDLERGCHLLVATPGRLVD 168
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 6322876 286 HLQNTKVIKEQlsqsLRYIVLDEGDKLMELGFDETISEII 325
Cdd:cd18051 169 MLERGKIGLDY----CKYLVLDEADRMLDMGFEPQIRRIV 204
|
|
| DEADc_DDX5_DDX17 |
cd17966 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ... |
161-369 |
5.17e-32 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350724 [Multi-domain] Cd Length: 197 Bit Score: 123.25 E-value: 5.17e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 161 KMRIKKPTSIQKQAIPqiIGNAGKNDFFIhAQTGSGKTLSYLLPIISTIlNMDTHVDRTSGAFALVIAPTRELASQIYHV 240
Cdd:cd17966 7 RQGFTEPTAIQAQGWP--MALSGRDMVGI-AQTGSGKTLAFLLPAIVHI-NAQPPLERGDGPIVLVLAPTRELAQQIQQE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 241 C------STLVSCCHYlvpclliGGERKKSEKARLRKGCNFIIGTPGRVLDHLQNTKVIKEQLSqslrYIVLDEGDKLME 314
Cdd:cd17966 83 AnkfggsSRLRNTCVY-------GGAPKGPQIRDLRRGVEICIATPGRLIDFLDQGKTNLRRVT----YLVLDEADRMLD 151
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 6322876 315 LGFDetiSEIIKIVHDIPINSEKfpklphklvhMLCSATLTDGVNRLRNVALKDY 369
Cdd:cd17966 152 MGFE---PQIRKIVDQIRPDRQT----------LMWSATWPKEVRRLAEDFLKDY 193
|
|
| DEADc_DDX43_DDX53 |
cd17958 |
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ... |
160-368 |
1.81e-31 |
|
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350716 [Multi-domain] Cd Length: 197 Bit Score: 121.80 E-value: 1.81e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 160 QKMRIKKPTSIQKQAIPQIIGNagkNDFFIHAQTGSGKTLSYLLPIISTILNMDTHVDRTSGAFALVIAPTRELASQIYH 239
Cdd:cd17958 6 KKQGFEKPSPIQSQAWPIILQG---IDLIGVAQTGTGKTLAYLLPGFIHLDLQPIPREQRNGPGVLVLTPTRELALQIEA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 240 VCSTLvSCCHYLVPCLLIGGERKKSEKArLRKGCNFIIGTPGRvLDHLQNTKVIKeqlSQSLRYIVLDEGDKLMELGFDe 319
Cdd:cd17958 83 ECSKY-SYKGLKSVCVYGGGNRNEQIED-LSKGVDIIIATPGR-LNDLQMNNVIN---LKSITYLVLDEADRMLDMGFE- 155
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 6322876 320 tiSEIIKIVHDIPinsekfpklPHKLVhMLCSATLTDGVNRLRNVALKD 368
Cdd:cd17958 156 --PQIRKILLDIR---------PDRQT-IMTSATWPDGVRRLAQSYLKD 192
|
|
| DEADc_DDX51 |
cd17956 |
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ... |
154-373 |
4.45e-31 |
|
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350714 [Multi-domain] Cd Length: 231 Bit Score: 121.59 E-value: 4.45e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 154 LVSHLeQKMRIKKPTSIQKQAIPQIIGNAGKN------DFFIHAQTGSGKTLSYLLPIISTILnmDTHVDRTSgafALVI 227
Cdd:cd17956 1 LLKNL-QNNGITSAFPVQAAVIPWLLPSSKSTppyrpgDLCVSAPTGSGKTLAYVLPIVQALS--KRVVPRLR---ALIV 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 228 APTRELASQIYHVCSTLVSCCHYLVpcLLIGGERK-KSEKARLRKGC--------NFIIGTPGRVLDHLQNTKVIKeqLs 298
Cdd:cd17956 75 VPTKELVQQVYKVFESLCKGTGLKV--VSLSGQKSfKKEQKLLLVDTsgrylsrvDILVATPGRLVDHLNSTPGFT--L- 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 299 QSLRYIVLDEGDKLMELGFDETISEIIKIV--HDIPINSEKF-----PKLPHKLVHMLCSATLTDGVNRLRNVALKDYKL 371
Cdd:cd17956 150 KHLRFLVIDEADRLLNQSFQDWLETVMKALgrPTAPDLGSFGdanllERSVRPLQKLLFSATLTRDPEKLSSLKLHRPRL 229
|
..
gi 6322876 372 IS 373
Cdd:cd17956 230 FT 231
|
|
| PRK11192 |
PRK11192 |
ATP-dependent RNA helicase SrmB; Provisional |
144-577 |
9.85e-31 |
|
ATP-dependent RNA helicase SrmB; Provisional
Pssm-ID: 236877 [Multi-domain] Cd Length: 434 Bit Score: 125.83 E-value: 9.85e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 144 QFASLGVSSLLVSHLeQKMRIKKPTSIQKQAIPQIIgnAGKnDFFIHAQTGSGKTLSYLLPIISTILNmdtHVDRTSG-A 222
Cdd:PRK11192 2 TFSELELDESLLEAL-QDKGYTRPTAIQAEAIPPAL--DGR-DVLGSAPTGTGKTAAFLLPALQHLLD---FPRRKSGpP 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 223 FALVIAPTRELASQIYHVCSTLVSCCHyLVPCLLIGGERKKSEKARLRKGCNFIIGTPGRVLDHLQntkviKEQLS-QSL 301
Cdd:PRK11192 75 RILILTPTRELAMQVADQARELAKHTH-LDIATITGGVAYMNHAEVFSENQDIVVATPGRLLQYIK-----EENFDcRAV 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 302 RYIVLDEGDKLMELGFDETISEIIKivhdipinsekfpKLPHKLVHMLCSATLT-DGVNRLRNVALKD-YKLISNGTKKD 379
Cdd:PRK11192 149 ETLILDEADRMLDMGFAQDIETIAA-------------ETRWRKQTLLFSATLEgDAVQDFAERLLNDpVEVEAEPSRRE 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 380 SDIVTvapdQLLQRITIVPPKLRLvtLAATLnnitkdfiasgQQSKTLRTIVFVSCSDSVEfhydafsgsdghhkNLTGd 459
Cdd:PRK11192 216 RKKIH----QWYYRADDLEHKTAL--LCHLL-----------KQPEVTRSIVFVRTRERVH--------------ELAG- 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 460 svRLLTKGntmFPCfsdsrdpdvvIYkLHGSLSQQMRTSTLQHFardneaTKGKHLIMFCTDVASRGLDLPHVGSVIELD 539
Cdd:PRK11192 264 --WLRKAG---INC----------CY-LEGEMVQAKRNEAIKRL------TDGRVNVLVATDVAARGIDIDDVSHVINFD 321
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 6322876 540 PPFAVEDHLHRVGRTARAGEKGE--SLL----FLLPGEEEKYMD 577
Cdd:PRK11192 322 MPRSADTYLHRIGRTGRAGRKGTaiSLVeahdHLLLGKIERYIE 365
|
|
| DEADc_DDX1 |
cd17938 |
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ... |
167-354 |
1.17e-30 |
|
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350696 [Multi-domain] Cd Length: 204 Bit Score: 119.35 E-value: 1.17e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 167 PTSIQKQAIPQIIGNAgknDFFIHAQTGSGKTLSYLLPIISTILnmdthvdrtsgafALVIAPTRELASQIYHVCSTLVS 246
Cdd:cd17938 22 PTDIQAEAIPLILGGG---DVLMAAETGSGKTGAFCLPVLQIVV-------------ALILEPSRELAEQTYNCIENFKK 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 247 cchY-----LVPCLLIGGERKKSEKARLRKGCNFIIGTPGRVLDHLQNTKVikeQLSQsLRYIVLDEGDKLMELGFDETI 321
Cdd:cd17938 86 ---YldnpkLRVALLIGGVKAREQLKRLESGVDIVVGTPGRLEDLIKTGKL---DLSS-VRFFVLDEADRLLSQGNLETI 158
|
170 180 190
....*....|....*....|....*....|....*
gi 6322876 322 SEIIKivhDIPI--NSEKfpklphKLVHMLCSATL 354
Cdd:cd17938 159 NRIYN---RIPKitSDGK------RLQVIVCSATL 184
|
|
| DEADc_DDX46 |
cd17953 |
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ... |
160-328 |
2.93e-30 |
|
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350711 [Multi-domain] Cd Length: 222 Bit Score: 119.02 E-value: 2.93e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 160 QKMRIKKPTSIQKQAIPQIIgnAGKnDFFIHAQTGSGKTLSYLLPIISTILNMDThVDRTSGAFALVIAPTRELASQIYH 239
Cdd:cd17953 28 KKLGYEKPTPIQAQALPAIM--SGR-DVIGIAKTGSGKTLAFLLPMFRHIKDQRP-VKPGEGPIGLIMAPTRELALQIYV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 240 VCS------TLVSCCHYlvpclliGGERKKSEKARLRKGCNFIIGTPGRVLDHL--QNTKVIkeqlsqSLR---YIVLDE 308
Cdd:cd17953 104 ECKkfskalGLRVVCVY-------GGSGISEQIAELKRGAEIVVCTPGRMIDILtaNNGRVT------NLRrvtYVVLDE 170
|
170 180
....*....|....*....|
gi 6322876 309 GDKLMELGFDETISEIIKIV 328
Cdd:cd17953 171 ADRMFDMGFEPQIMKIVNNI 190
|
|
| DEADc_EIF4A |
cd17939 |
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ... |
166-356 |
4.06e-30 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350697 [Multi-domain] Cd Length: 199 Bit Score: 117.81 E-value: 4.06e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 166 KPTSIQKQAIPQIIGnagKNDFFIHAQTGSGKTLSYllpIISTILNMDTHVDRTSgafALVIAPTRELASQIYHVCSTLv 245
Cdd:cd17939 19 KPSAIQQRAIVPIIK---GRDVIAQAQSGTGKTATF---SIGALQRIDTTVRETQ---ALVLAPTRELAQQIQKVVKAL- 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 246 sCCHYLVPC-LLIGGERKKSEKARLRKGCNFIIGTPGRVLDHLQNTKVIKEQlsqsLRYIVLDEGDKLMELGFDETISEI 324
Cdd:cd17939 89 -GDYMGVKVhACIGGTSVREDRRKLQYGPHIVVGTPGRVFDMLQRRSLRTDK----IKMFVLDEADEMLSRGFKDQIYDI 163
|
170 180 190
....*....|....*....|....*....|..
gi 6322876 325 IKivhdipinsekfpKLPHKLVHMLCSATLTD 356
Cdd:cd17939 164 FQ-------------FLPPETQVVLFSATMPH 182
|
|
| DEADc_DDX28 |
cd17948 |
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ... |
160-361 |
1.47e-29 |
|
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350706 [Multi-domain] Cd Length: 231 Bit Score: 117.08 E-value: 1.47e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 160 QKMRIKKPTSIQKQAIPQIIGNagkNDFFIHAQTGSGKTLSYLLPIISTILNmDTHVD--RTSGAFALVIAPTRELASQI 237
Cdd:cd17948 6 QRQGITKPTTVQKQGIPSILRG---RNTLCAAETGSGKTLTYLLPIIQRLLR-YKLLAegPFNAPRGLVITPSRELAEQI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 238 YHVCSTLVSCCHYLVPCLLiGGERKKSEKARLRKGCNFIIGTPGrVLDHLQNTKVIKeqLSQsLRYIVLDEGDKLMELGF 317
Cdd:cd17948 82 GSVAQSLTEGLGLKVKVIT-GGRTKRQIRNPHFEEVDILVATPG-ALSKLLTSRIYS--LEQ-LRHLVLDEADTLLDDSF 156
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 6322876 318 DETISEIIKIVHDIPINSEKFPKLPHKLVHMLCSATLTDGVNRL 361
Cdd:cd17948 157 NEKLSHFLRRFPLASRRSENTDGLDPGTQLVLVSATMPSGVGEV 200
|
|
| DEADc_DDX42 |
cd17952 |
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ... |
161-325 |
2.16e-29 |
|
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350710 [Multi-domain] Cd Length: 197 Bit Score: 115.59 E-value: 2.16e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 161 KMRIKKPTSIQKQAIPQIIgnAGKNDFFIhAQTGSGKTLSYLLPIISTIlnMDT-HVDRTSGAFALVIAPTRELASQIYH 239
Cdd:cd17952 7 KQEYEQPTPIQAQALPVAL--SGRDMIGI-AKTGSGKTAAFIWPMLVHI--MDQrELEKGEGPIAVIVAPTRELAQQIYL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 240 VCSTLvSCCHYLVPCLLIGGERKKSEKARLRKGCNFIIGTPGRVLDHLQntkvIKEQLSQSLRYIVLDEGDKLMELGFDE 319
Cdd:cd17952 82 EAKKF-GKAYNLRVVAVYGGGSKWEQAKALQEGAEIVVATPGRLIDMVK----KKATNLQRVTYLVLDEADRMFDMGFEY 156
|
....*.
gi 6322876 320 TISEII 325
Cdd:cd17952 157 QVRSIV 162
|
|
| DEADc_DDX24 |
cd17946 |
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ... |
160-380 |
6.71e-29 |
|
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350704 [Multi-domain] Cd Length: 235 Bit Score: 115.41 E-value: 6.71e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 160 QKMRIKKPTSIQKQAIPQIIgnAGKNDFFIHAQTGSGKTLSYLLPIISTILNMDTHVDRTS---GAFALVIAPTRELASQ 236
Cdd:cd17946 6 ADLGFSEPTPIQALALPAAI--RDGKDVIGAAETGSGKTLAFGIPILERLLSQKSSNGVGGkqkPLRALILTPTRELAVQ 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 237 iyhVCSTLVSCCHYLVP--CLLIGGERKKSEKARLRKGCNFIIGTPGRVLDHLQNTKVIKEQLsQSLRYIVLDEGDKLME 314
Cdd:cd17946 84 ---VKDHLKAIAKYTNIkiASIVGGLAVQKQERLLKKRPEIVVATPGRLWELIQEGNEHLANL-KSLRFLVLDEADRMLE 159
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6322876 315 LG-FDEtISEIIKIVHdipiNSEKFPKlpHKLVHMLCSATLT-DGVNRLRNVALKDYKLISNGTKKDS 380
Cdd:cd17946 160 KGhFAE-LEKILELLN----KDRAGKK--RKRQTFVFSATLTlDHQLPLKLNSKKKKKKKEKKQKLEL 220
|
|
| PTZ00424 |
PTZ00424 |
helicase 45; Provisional |
165-577 |
7.27e-28 |
|
helicase 45; Provisional
Pssm-ID: 185609 [Multi-domain] Cd Length: 401 Bit Score: 116.46 E-value: 7.27e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 165 KKPTSIQKQAIPQIIGNagkNDFFIHAQTGSGKTLSYllpIISTILNMDTHVDRTSgafALVIAPTRELASQIYHVCSTL 244
Cdd:PTZ00424 49 EKPSAIQQRGIKPILDG---YDTIGQAQSGTGKTATF---VIAALQLIDYDLNACQ---ALILAPTRELAQQIQKVVLAL 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 245 VSCCHylVPC-LLIGGERKKSEKARLRKGCNFIIGTPGRVLDHLQNtkviKEQLSQSLRYIVLDEGDKLMELGFDETISE 323
Cdd:PTZ00424 120 GDYLK--VRChACVGGTVVRDDINKLKAGVHMVVGTPGRVYDMIDK----RHLRVDDLKLFILDEADEMLSRGFKGQIYD 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 324 IikivhdipinsekFPKLPHKLVHMLCSATLTDGVNRLRNVALKDYKLIsngtkkdsdivTVAPDQLlqritivppklrl 403
Cdd:PTZ00424 194 V-------------FKKLPPDVQVALFSATMPNEILELTTKFMRDPKRI-----------LVKKDEL------------- 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 404 vtlaaTLNNITKDFIASGQQSKTLRTIVFVscsdsvefhYDAFSGSDGHHKNLTGDSVRLLTKgntmfpcfsDSRDPDVV 483
Cdd:PTZ00424 237 -----TLEGIRQFYVAVEKEEWKFDTLCDL---------YETLTITQAIIYCNTRRKVDYLTK---------KMHERDFT 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 484 IYKLHGSLSQQMRTSTLQHFardneaTKGKHLIMFCTDVASRGLDLPHVGSVIELDPPFAVEDHLHRVGRTARAGEKGES 563
Cdd:PTZ00424 294 VSCMHGDMDQKDRDLIMREF------RSGSTRVLITTDLLARGIDVQQVSLVINYDLPASPENYIHRIGRSGRFGRKGVA 367
|
410
....*....|....
gi 6322876 564 LLFLLPGEEEKYMD 577
Cdd:PTZ00424 368 INFVTPDDIEQLKE 381
|
|
| DEADc_DDX17 |
cd18050 |
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ... |
163-375 |
1.51e-27 |
|
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350808 [Multi-domain] Cd Length: 271 Bit Score: 112.80 E-value: 1.51e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 163 RIKKPTSIQKQAIPqiIGNAGKNDFFIhAQTGSGKTLSYLLPIISTIlNMDTHVDRTSGAFALVIAPTRELASQIYHV-- 240
Cdd:cd18050 81 NFKEPTPIQCQGFP--LALSGRDMVGI-AQTGSGKTLAYLLPAIVHI-NHQPYLERGDGPICLVLAPTRELAQQVQQVad 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 241 ----CSTLVSCCHYlvpclliGGERKKSEKARLRKGCNFIIGTPGRVLDHLQNTKVikeqlsqSLR---YIVLDEGDKLM 313
Cdd:cd18050 157 dygkSSRLKSTCIY-------GGAPKGPQIRDLERGVEICIATPGRLIDFLEAGKT-------NLRrctYLVLDEADRML 222
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6322876 314 ELGFDetiSEIIKIVHDIPINSEKfpklphklvhMLCSATLTDGVNRLRNVALKDYKLISNG 375
Cdd:cd18050 223 DMGFE---PQIRKIVDQIRPDRQT----------LMWSATWPKEVRQLAEDFLRDYVQINIG 271
|
|
| DEADc_DDX5 |
cd18049 |
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ... |
161-375 |
4.67e-27 |
|
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350807 [Multi-domain] Cd Length: 234 Bit Score: 110.10 E-value: 4.67e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 161 KMRIKKPTSIQKQAIPqiIGNAGKnDFFIHAQTGSGKTLSYLLPIISTIlNMDTHVDRTSGAFALVIAPTRELASQIYHV 240
Cdd:cd18049 41 RQNFTEPTAIQAQGWP--VALSGL-DMVGVAQTGSGKTLSYLLPAIVHI-NHQPFLERGDGPICLVLAPTRELAQQVQQV 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 241 CSTLVSCCHYLVPCLLiGGERKKSEKARLRKGCNFIIGTPGRVLDHLQNTKVIKEQLSqslrYIVLDEGDKLMELGFDet 320
Cdd:cd18049 117 AAEYGRACRLKSTCIY-GGAPKGPQIRDLERGVEICIATPGRLIDFLEAGKTNLRRCT----YLVLDEADRMLDMGFE-- 189
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 6322876 321 iSEIIKIVHDIPINSEKfpklphklvhMLCSATLTDGVNRLRNVALKDYKLISNG 375
Cdd:cd18049 190 -PQIRKIVDQIRPDRQT----------LMWSATWPKEVRQLAEDFLKDYIHINIG 233
|
|
| DEADc_DDX59 |
cd17962 |
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ... |
167-373 |
1.65e-26 |
|
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350720 [Multi-domain] Cd Length: 193 Bit Score: 107.25 E-value: 1.65e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 167 PTSIQKQAIPqiIGNAGKnDFFIHAQTGSGKTLSYLLPIISTILnmdTHVDRTSgafALVIAPTRELASQIYHVCSTLVS 246
Cdd:cd17962 13 PTPIQMQMIP--VGLLGR-DILASADTGSGKTAAFLLPVIIRCL---TEHRNPS---ALILTPTRELAVQIEDQAKELMK 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 247 CCHYLVPCLLIGGERKKSEKARLRKGCNFIIGTPGRVLDHLQNTKVikeQLSqSLRYIVLDEGDKLMELGFDETISEIik 326
Cdd:cd17962 84 GLPPMKTALLVGGLPLPPQLYRLQQGVKVIIATPGRLLDILKQSSV---ELD-NIKIVVVDEADTMLKMGFQQQVLDI-- 157
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 6322876 327 ivhdipinsekFPKLPHKLVHMLCSATLTDGVNRLRNVALKDYKLIS 373
Cdd:cd17962 158 -----------LENISHDHQTILVSATIPRGIEQLAGQLLQNPVRIT 193
|
|
| DEADc_DDX20 |
cd17943 |
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ... |
166-353 |
9.62e-26 |
|
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350701 [Multi-domain] Cd Length: 192 Bit Score: 105.04 E-value: 9.62e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 166 KPTSIQKQAIPqiIGNAGKnDFFIHAQTGSGKTLSYllpIISTILNMDTHVDRTSgafALVIAPTRELASQIYHVCSTLV 245
Cdd:cd17943 12 RPSPIQLAAIP--LGLAGH-DLIVQAKSGTGKTLVF---VVIALESLDLERRHPQ---VLILAPTREIAVQIHDVFKKIG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 246 SCCHYLVPCLLIGGERKKSEKARLrKGCNFIIGTPGRVLdHLQNTKVIKeqlSQSLRYIVLDEGDKLMELGFDETISEII 325
Cdd:cd17943 83 KKLEGLKCEVFIGGTPVKEDKKKL-KGCHIAVGTPGRIK-QLIELGALN---VSHVRLFVLDEADKLMEGSFQKDVNWIF 157
|
170 180
....*....|....*....|....*...
gi 6322876 326 kivhdipinsEKFPKLPHKLVhmlCSAT 353
Cdd:cd17943 158 ----------SSLPKNKQVIA---FSAT 172
|
|
| DEADc_DDX6 |
cd17940 |
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ... |
166-353 |
2.03e-24 |
|
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350698 [Multi-domain] Cd Length: 201 Bit Score: 101.61 E-value: 2.03e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 166 KPTSIQKQAIPQIIgnAGKnDFFIHAQTGSGKTLSYLLPIistiLNMdthVDRTSGAF-ALVIAPTRELASQIYHVCSTL 244
Cdd:cd17940 21 KPSPIQEESIPIAL--SGR-DILARAKNGTGKTGAYLIPI----LEK---IDPKKDVIqALILVPTRELALQTSQVCKEL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 245 VSccHYLVPCLLI-GGERKKSEKARLRKGCNFIIGTPGRVLDhLQNTKVIKeqLSQsLRYIVLDEGDKLMELGFDETISE 323
Cdd:cd17940 91 GK--HMGVKVMVTtGGTSLRDDIMRLYQTVHVLVGTPGRILD-LAKKGVAD--LSH-CKTLVLDEADKLLSQDFQPIIEK 164
|
170 180 190
....*....|....*....|....*....|
gi 6322876 324 IIKivhdipinsekfpKLPHKLVHMLCSAT 353
Cdd:cd17940 165 ILN-------------FLPKERQILLFSAT 181
|
|
| DEADc_EIF4AII_EIF4AI_DDX2 |
cd18046 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ... |
165-358 |
7.81e-24 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350804 [Multi-domain] Cd Length: 201 Bit Score: 99.83 E-value: 7.81e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 165 KKPTSIQKQAI-PQIIGNagknDFFIHAQTGSGKTLSYLLPIISTIlnmDTHVDRTSgafALVIAPTRELASQIYHVCST 243
Cdd:cd18046 20 EKPSAIQQRAImPCIKGY----DVIAQAQSGTGKTATFSISILQQI---DTSLKATQ---ALVLAPTRELAQQIQKVVMA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 244 LVS----CCHylvPCllIGGERKKSEKARLRKGCNFIIGTPGRVLDHLqNTKVIKeqlSQSLRYIVLDEGDKLMELGFDE 319
Cdd:cd18046 90 LGDymgiKCH---AC--IGGTSVRDDAQKLQAGPHIVVGTPGRVFDMI-NRRYLR---TDYIKMFVLDEADEMLSRGFKD 160
|
170 180 190
....*....|....*....|....*....|....*....
gi 6322876 320 TISEIikivhdipinsekFPKLPHKLVHMLCSATLTDGV 358
Cdd:cd18046 161 QIYDI-------------FQKLPPDTQVVLLSATMPNDV 186
|
|
| DEADc_DDX21_DDX50 |
cd17944 |
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ... |
183-367 |
5.92e-23 |
|
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350702 [Multi-domain] Cd Length: 202 Bit Score: 97.23 E-value: 5.92e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 183 GKnDFFIHAQTGSGKTLSYLLPIISTILNMDTHVDRTSGAFALVIAPTRELASQIYH----VCSTLVSCCHYlvpclliG 258
Cdd:cd17944 27 GK-DLIAQARTGTGKTFSFAIPLIEKLQEDQQPRKRGRAPKVLVLAPTRELANQVTKdfkdITRKLSVACFY-------G 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 259 GERKKSEKARLRKGCNFIIGTPGRVLDHLQNTKVikeQLSQsLRYIVLDEGDKLMELGFDETISEIIKIVHDipINSEKF 338
Cdd:cd17944 99 GTPYQQQIFAIRNGIDILVGTPGRIKDHLQNGRL---DLTK-LKHVVLDEVDQMLDMGFAEQVEEILSVSYK--KDSEDN 172
|
170 180
....*....|....*....|....*....
gi 6322876 339 PKLphklvhMLCSATLTDGVnrlRNVALK 367
Cdd:cd17944 173 PQT------LLFSATCPDWV---YNVAKK 192
|
|
| DEADc_DDX19_DDX25 |
cd17963 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ... |
160-358 |
3.18e-22 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350721 [Multi-domain] Cd Length: 196 Bit Score: 94.95 E-value: 3.18e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 160 QKMRIKKPTSIQKQAIPQIIGNAGKNDFFiHAQTGSGKTLSYllpiistILNMDTHVDRTSGAF-ALVIAPTRELASQIY 238
Cdd:cd17963 10 YAMGFNKPSKIQETALPLILSDPPENLIA-QSQSGTGKTAAF-------VLAMLSRVDPTLKSPqALCLAPTRELARQIG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 239 HVCSTLVSCCHYLVPCLLIGGERKKSEKARlrkgCNFIIGTPGRVLDHLQntkviKEQLS-QSLRYIVLDEGDKLMEL-G 316
Cdd:cd17963 82 EVVEKMGKFTGVKVALAVPGNDVPRGKKIT----AQIVIGTPGTVLDWLK-----KRQLDlKKIKILVLDEADVMLDTqG 152
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 6322876 317 FDEtisEIIKIVHDIPINsekfpklphklVHMLC-SATLTDGV 358
Cdd:cd17963 153 HGD---QSIRIKRMLPRN-----------CQILLfSATFPDSV 181
|
|
| DEADc_EIF4AIII_DDX48 |
cd18045 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ... |
165-358 |
1.15e-21 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350803 [Multi-domain] Cd Length: 201 Bit Score: 93.69 E-value: 1.15e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 165 KKPTSIQKQAIPQIIGNagkNDFFIHAQTGSGKTLSYLLPIISTIlnmDTHVDRTSgafALVIAPTRELASQIYHVCSTL 244
Cdd:cd18045 20 EKPSAIQQRAIKPIIKG---RDVIAQSQSGTGKTATFSISVLQCL---DIQVRETQ---ALILSPTRELAVQIQKVLLAL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 245 vscCHYL-VPC-LLIGGERKKSEKARLRKGCNFIIGTPGRVLDHLQNtkviKEQLSQSLRYIVLDEGDKLMELGFDETIs 322
Cdd:cd18045 91 ---GDYMnVQChACIGGTSVGDDIRKLDYGQHIVSGTPGRVFDMIRR----RSLRTRHIKMLVLDEADEMLNKGFKEQI- 162
|
170 180 190
....*....|....*....|....*....|....*.
gi 6322876 323 eiikivHDIpinsekFPKLPHKLVHMLCSATLTDGV 358
Cdd:cd18045 163 ------YDV------YRYLPPATQVVLVSATLPQDI 186
|
|
| DUF4217 |
pfam13959 |
Domain of unknown function (DUF4217); This short domain is found at the C-terminus of many ... |
640-700 |
5.72e-20 |
|
Domain of unknown function (DUF4217); This short domain is found at the C-terminus of many helicase proteins.
Pssm-ID: 464056 [Multi-domain] Cd Length: 59 Bit Score: 83.99 E-value: 5.72e-20
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6322876 640 HLNIERRVVGDSAFKNLAVKGFISHVRAYATHISqeKKFFNVKFLHLGHLAKSFGLRERPK 700
Cdd:pfam13959 1 QLQLEKLVLKDRELKELAQKAFVSYVRAYSKHLA--KSIFNVKKLDLGHLAKSFGLLRAPK 59
|
|
| DEADc_MRH4 |
cd17965 |
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ... |
166-354 |
1.45e-18 |
|
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350723 [Multi-domain] Cd Length: 251 Bit Score: 85.89 E-value: 1.45e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 166 KPTSIQKQAIPQIIGN-------AGKND------FFIHAQTGSGKTLSYLLPIISTILNMDTHVDRTSGAF--------- 223
Cdd:cd17965 30 KPSPIQTLAIKKLLKTlmrkvtkQTSNEepklevFLLAAETGSGKTLAYLAPLLDYLKRQEQEPFEEAEEEyesakdtgr 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 224 --ALVIAPTRELASQIYhvcSTLVSCCHYL-----VPCLLIGGERKKSEKArLRKGCNFIIGTPGRvldhLQNTKVIKEQ 296
Cdd:cd17965 110 prSVILVPTHELVEQVY---SVLKKLSHTVklgikTFSSGFGPSYQRLQLA-FKGRIDILVTTPGK----LASLAKSRPK 181
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 6322876 297 LSQSLRYIVLDEGDKLMELGFDETISEIIKivhdipinseKFPKLpHKLVhmLCSATL 354
Cdd:cd17965 182 ILSRVTHLVVDEADTLFDRSFLQDTTSIIK----------RAPKL-KHLI--LCSATI 226
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
484-558 |
4.92e-18 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 79.18 E-value: 4.92e-18
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6322876 484 IYKLHGSLSQQMRTSTLQHFArdneatKGKHLIMFCTDVASRGLDLPHVGSVIELDPPFAVEDHLHRVGRTARAG 558
Cdd:smart00490 14 VARLHGGLSQEEREEILDKFN------NGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGRAG 82
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
484-558 |
7.94e-18 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 79.56 E-value: 7.94e-18
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6322876 484 IYKLHGSLSQQMRTSTLQHFArdneatKGKHLIMFCTDVASRGLDLPHVGSVIELDPPFAVEDHLHRVGRTARAG 558
Cdd:pfam00271 41 VARLHGDLSQEEREEILEDFR------KGKIDVLVATDVAERGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEADc_DDX39 |
cd17950 |
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ... |
167-367 |
3.16e-17 |
|
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350708 [Multi-domain] Cd Length: 208 Bit Score: 80.85 E-value: 3.16e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 167 PTSIQKQAIPQIIGNAgknDFFIHAQTGSGKTLSYLLPIISTILNMDTHVDrtsgafALVIAPTRELASQIyhvCSTLVS 246
Cdd:cd17950 25 PSEVQHECIPQAILGM---DVLCQAKSGMGKTAVFVLSTLQQLEPVDGQVS------VLVICHTRELAFQI---SNEYER 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 247 CCHYL----VPCLLIGGERKKSEKARLRKGCNFIIGTPGRVLDHLQNTKVikeQLSQsLRYIVLDEGDKLME-LGFDETI 321
Cdd:cd17950 93 FSKYMpnvkTAVFFGGVPIKKDIEVLKNKCPHIVVGTPGRILALVREKKL---KLSH-VKHFVLDECDKMLEqLDMRRDV 168
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 6322876 322 SEIikivhdipinsekFPKLPHKLVHMLCSATLTdgvNRLRNVALK 367
Cdd:cd17950 169 QEI-------------FRATPHDKQVMMFSATLS---KEIRPVCKK 198
|
|
| DEADc_DDX25 |
cd18048 |
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ... |
162-358 |
5.20e-11 |
|
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350806 [Multi-domain] Cd Length: 229 Bit Score: 63.12 E-value: 5.20e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 162 MRIKKPTSIQKQAIPQIIGNAGKNdFFIHAQTGSGKTLSYLLPIISTILNMDTHVDrtsgafALVIAPTRELASQIYHVC 241
Cdd:cd18048 36 MGFNRPSKIQENALPMMLADPPQN-LIAQSQSGTGKTAAFVLAMLSRVDALKLYPQ------CLCLSPTFELALQTGKVV 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 242 STLVSCCHYLVPCLLIGGERKkSEKARLRKgcNFIIGTPGRVLDHLQNTKVIKeqlSQSLRYIVLDEGDKLMEL-GFDEt 320
Cdd:cd18048 109 EEMGKFCVGIQVIYAIRGNRP-GKGTDIEA--QIVIGTPGTVLDWCFKLRLID---VTNISVFVLDEADVMINVqGHSD- 181
|
170 180 190
....*....|....*....|....*....|....*...
gi 6322876 321 iseiikivHDIPINSekfpKLPHKLVHMLCSATLTDGV 358
Cdd:cd18048 182 --------HSVRVKR----SMPKECQMLLFSATFEDSV 207
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
139-308 |
5.30e-10 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 62.93 E-value: 5.30e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 139 PLKGDQFASL--GVSSLLVSHLEQKmRIKKPTSIQKQAIPQIIgnAGKNdFFIHAQTGSGKTLSYLLPIISTILnmdthv 216
Cdd:COG1205 28 PAREARYAPWpdWLPPELRAALKKR-GIERLYSHQAEAIEAAR--AGKN-VVIATPTASGKSLAYLLPVLEALL------ 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 217 dRTSGAFALVIAPTRELAS-QIyhvcSTLVSCCHYLVPCLLIG---GERKKSEKARLRKGCNFIIGTPgrvlD--HL--- 287
Cdd:COG1205 98 -EDPGATALYLYPTKALARdQL----RRLRELAEALGLGVRVAtydGDTPPEERRWIREHPDIVLTNP----DmlHYgll 168
|
170 180
....*....|....*....|..
gi 6322876 288 -QNTKVIKeqLSQSLRYIVLDE 308
Cdd:COG1205 169 pHHTRWAR--FFRNLRYVVIDE 188
|
|
| DEADc_DDX19 |
cd18047 |
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both ... |
161-372 |
2.81e-09 |
|
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. DDX19 functions in the nucleus in resolving RNA:DNA hybrids (R-loops). Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of DDX19 from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops. DDX19 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350805 [Multi-domain] Cd Length: 205 Bit Score: 57.81 E-value: 2.81e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 161 KMRIKKPTSIQKQAIPQIIGNAGKNdFFIHAQTGSGKTLSYLLPIIStilnmdtHVDRTSG-AFALVIAPTRELASQIYH 239
Cdd:cd18047 18 AMGFNRPSKIQENALPLMLAEPPQN-LIAQSQSGTGKTAAFVLAMLS-------QVEPANKyPQCLCLSPTYELALQTGK 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 240 VCSTLVSCCHYLVPCLLIGGERKKsEKARLRKgcNFIIGTPGRVLDHLQNTKVIKeqlSQSLRYIVLDEGDKLMELGFDE 319
Cdd:cd18047 90 VIEQMGKFYPELKLAYAVRGNKLE-RGQKISE--QIVIGTPGTVLDWCSKLKFID---PKKIKVFVLDEADVMIATQGHQ 163
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 6322876 320 tiseiikivhDIPINSEKFpkLPHKLVHMLCSATLTDGVNRLRNVALKDYKLI 372
Cdd:cd18047 164 ----------DQSIRIQRM--LPRNCQMLLFSATFEDSVWKFAQKVVPDPNVI 204
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
185-308 |
4.27e-09 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 55.87 E-value: 4.27e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 185 NDFFIHAQTGSGKTLSYLLPIIstilnmdtHVDRTSGAFALVIAPTRELASQIYHVCSTLVScchYLVPCLLIGGERKKS 264
Cdd:cd00046 2 ENVLITAPTGSGKTLAALLAAL--------LLLLKKGKKVLVLVPTKALALQTAERLRELFG---PGIRVAVLVGGSSAE 70
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 6322876 265 EKARLRKGCN-FIIGTPgrvlDHLQNTKVIKEQLSQS-LRYIVLDE 308
Cdd:cd00046 71 EREKNKLGDAdIIIATP----DMLLNLLLREDRLFLKdLKLIIVDE 112
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
182-308 |
1.51e-08 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 54.90 E-value: 1.51e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 182 AGKNdFFIHAQTGSGKTLSYLLPIISTILnmdthvdRTSGAFALVIAPTRELA-SQIYHVCSTLVSCCHYLVPCLLIGGE 260
Cdd:cd17923 14 AGRS-VVVTTGTASGKSLCYQLPILEALL-------RDPGSRALYLYPTKALAqDQLRSLRELLEQLGLGIRVATYDGDT 85
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 6322876 261 RKKSEKARLRKGCNFIIGTPgRVLDH--LQNTKVIKEQLSqSLRYIVLDE 308
Cdd:cd17923 86 PREERRAIIRNPPRILLTNP-DMLHYalLPHHDRWARFLR-NLRYVVLDE 133
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
516-566 |
5.59e-07 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 47.70 E-value: 5.59e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 6322876 516 IMFCTDVASRGLDLPHVGSVIELDPPFAVEDHLHRVGRTARAG-EKGESLLF 566
Cdd:cd18785 25 ILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGkDEGEVILF 76
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
171-567 |
9.89e-07 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 51.95 E-value: 9.89e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 171 QKQAIPQIIG--NAGKNDFFIHAQTGSGKTLsyllpIISTILNMDTHVDRTsgafaLVIAPTRELASQIYHVCSTLVscc 248
Cdd:COG1061 85 QQEALEALLAalERGGGRGLVVAPTGTGKTV-----LALALAAELLRGKRV-----LVLVPRRELLEQWAEELRRFL--- 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 249 hylvPCLLIGGERKKSekarlrkGCNFIIGTPGRVldhlqNTKVIKEQLSQSLRYIVLDEGDKLMELGFDETIsEIIKIV 328
Cdd:COG1061 152 ----GDPLAGGGKKDS-------DAPITVATYQSL-----ARRAHLDELGDRFGLVIIDEAHHAGAPSYRRIL-EAFPAA 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 329 HDI-----PINSEKFPKLPHKLVHMLCSATLTDGVNR--LRNValkDYKLISNGTKKDSDIVTVAPDQLLQRITIVPPKL 401
Cdd:COG1061 215 YRLgltatPFRSDGREILLFLFDGIVYEYSLKEAIEDgyLAPP---EYYGIRVDLTDERAEYDALSERLREALAADAERK 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 402 RLVtlaatLNNITKDFiasgqqSKTLRTIVFVSCSDSVEFHYDAFsgsdghhknltgdsvrlltkgntmfpcfsdsRDPD 481
Cdd:COG1061 292 DKI-----LRELLREH------PDDRKTLVFCSSVDHAEALAELL-------------------------------NEAG 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 482 VVIYKLHGSLSQQMRTSTLQHFARdneatkGKHLIMFCTDVASRGLDLPHVGSVIELDPPFAVEDHLHRVGRTARAGEKG 561
Cdd:COG1061 330 IRAAVVTGDTPKKEREEILEAFRD------GELRILVTVDVLNEGVDVPRLDVAILLRPTGSPREFIQRLGRGLRPAPGK 403
|
....*.
gi 6322876 562 ESLLFL 567
Cdd:COG1061 404 EDALVY 409
|
|
| DEXHc_LHR-like |
cd17922 |
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ... |
189-308 |
2.77e-06 |
|
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350680 [Multi-domain] Cd Length: 166 Bit Score: 47.96 E-value: 2.77e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 189 IHAQTGSGKTLSYLLPIISTILNmdthvDRTSGAFALVIAPTRELASQIYHVCSTLVSCCHYLVPCLLIGGERKKSEKAR 268
Cdd:cd17922 6 IAAPTGSGKTEAAFLPALSSLAD-----EPEKGVQVLYISPLKALINDQERRLEEPLDEIDLEIPVAVRHGDTSQSEKAK 80
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 6322876 269 LRKGCNFI-IGTPGRVLDHLQNTKVikEQLSQSLRYIVLDE 308
Cdd:cd17922 81 QLKNPPGIlITTPESLELLLVNKKL--RELFAGLRYVVVDE 119
|
|
| PRK13767 |
PRK13767 |
ATP-dependent helicase; Provisional |
165-238 |
1.86e-05 |
|
ATP-dependent helicase; Provisional
Pssm-ID: 237497 [Multi-domain] Cd Length: 876 Bit Score: 48.34 E-value: 1.86e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6322876 165 KKPTSIQKQAIPQIigNAGKNdFFIHAQTGSGKTLSYLLPIISTILNMDTHVDRTSGAFALVIAPTRELASQIY 238
Cdd:PRK13767 31 GTFTPPQRYAIPLI--HEGKN-VLISSPTGSGKTLAAFLAIIDELFRLGREGELEDKVYCLYVSPLRALNNDIH 101
|
|
| Lhr |
COG1201 |
Lhr-like helicase [Replication, recombination and repair]; |
163-234 |
1.88e-05 |
|
Lhr-like helicase [Replication, recombination and repair];
Pssm-ID: 440814 [Multi-domain] Cd Length: 850 Bit Score: 48.17 E-value: 1.88e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6322876 163 RIKKPTSIQKQAIPQIIgnAGKNdFFIHAQTGSGKTLSYLLPIISTILNMDTHVDRTSGAFALVIAPTRELA 234
Cdd:COG1201 21 RFGAPTPPQREAWPAIA--AGES-TLLIAPTGSGKTLAAFLPALDELARRPRPGELPDGLRVLYISPLKALA 89
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
170-308 |
3.88e-05 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 44.95 E-value: 3.88e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 170 IQKQAIPQIiGNAGKNdFFIHAQTGSGKTLSYLLPIISTIlnmdthvdRTSGAFALVIAPTRELASQIYhvcSTLVSC-C 248
Cdd:cd17921 5 IQREALRAL-YLSGDS-VLVSAPTSSGKTLIAELAILRAL--------ATSGGKAVYIAPTRALVNQKE---ADLRERfG 71
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 249 HYLVPCLLIGGERkkSEKARLRKGCNFIIGTPGRVLDHLQNtkvIKEQLSQSLRYIVLDE 308
Cdd:cd17921 72 PLGKNVGLLTGDP--SVNKLLLAEADILVATPEKLDLLLRN---GGERLIQDVRLVVVDE 126
|
|
| DEXHc_RecG |
cd17918 |
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase ... |
166-279 |
7.92e-05 |
|
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase RecG family is part of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350676 [Multi-domain] Cd Length: 180 Bit Score: 43.94 E-value: 7.92e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 166 KPTSIQKQAIPQIIG--NAGKN-DFFIHAQTGSGKTLSYLLPIISTILNmdthvdrtsGAFALVIAPTRELASQIYHVCS 242
Cdd:cd17918 15 SLTKDQAQAIKDIEKdlHSPEPmDRLLSGDVGSGKTLVALGAALLAYKN---------GKQVAILVPTEILAHQHYEEAR 85
|
90 100 110
....*....|....*....|....*....|....*..
gi 6322876 243 TLVScchyLVPCLLIGGERKKSEKArlrkGCNFIIGT 279
Cdd:cd17918 86 KFLP----FINVELVTGGTKAQILS----GISLLVGT 114
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
171-238 |
2.69e-04 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 44.12 E-value: 2.69e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6322876 171 QKQAIPQIIGNaGKNdFFIHAQTGSGKTLSYLLPIISTILNmdthvdrtsGAFALVIAPTRELASQIY 238
Cdd:COG1204 27 QAEALEAGLLE-GKN-LVVSAPTASGKTLIAELAILKALLN---------GGKALYIVPLRALASEKY 83
|
|
| SF2_C_LHR |
cd18796 |
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a ... |
488-569 |
4.25e-04 |
|
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases. LHR family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350183 [Multi-domain] Cd Length: 150 Bit Score: 41.48 E-value: 4.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 488 HGSLSQQMRTSTLQHFARDNEATkgkhliMFCTDVASRGLDLPHVGSVIELDPPFAVEDHLHRVGRTARAGeKGESLLFL 567
Cdd:cd18796 75 HGSLSRELREEVEAALKRGDLKV------VVATSSLELGIDIGDVDLVIQIGSPKSVARLLQRLGRSGHRP-GAASKGRL 147
|
..
gi 6322876 568 LP 569
Cdd:cd18796 148 VP 149
|
|
| DEXHc_RecG |
cd17992 |
DEXH/Q-box helicase domain of RecG; ATP-dependent DNA helicase RecG plays a critical role in ... |
194-308 |
1.92e-03 |
|
DEXH/Q-box helicase domain of RecG; ATP-dependent DNA helicase RecG plays a critical role in recombination and DNA repair. It is a member of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350750 [Multi-domain] Cd Length: 225 Bit Score: 40.59 E-value: 1.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 194 GSGKTLSYLLPIISTILNmdthvdrtsGAFALVIAPTRELASQIYHVCSTLVSCCHYLVpCLLIG---GERKKSEKARLR 270
Cdd:cd17992 76 GSGKTVVAALAMLAAVEN---------GYQVALMAPTEILAEQHYDSLKKLLEPLGIRV-ALLTGstkAKEKREILEKIA 145
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 6322876 271 KG-CNFIIGTpgrvldHlqntKVIKEQLS-QSLRYIVLDE 308
Cdd:cd17992 146 SGeIDIVIGT------H----ALIQEDVEfHNLGLVIIDE 175
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
164-308 |
2.02e-03 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 39.58 E-value: 2.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322876 164 IKKPTSIQKQAIPQIIGNAGKND--FFIHAQTGSGKTLSYLlpIISTILNMDTHVDRTsgafaLVIAPTRELASQIYHVC 241
Cdd:pfam04851 1 KLELRPYQIEAIENLLESIKNGQkrGLIVMATGSGKTLTAA--KLIARLFKKGPIKKV-----LFLVPRKDLLEQALEEF 73
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6322876 242 STLVSCCHYLvpCLLIGGERKKSEkarlRKGCNFIIGTPGRVLDHLQNTKviKEQLSQSLRYIVLDE 308
Cdd:pfam04851 74 KKFLPNYVEI--GEIISGDKKDES----VDDNKIVVTTIQSLYKALELAS--LELLPDFFDVIIIDE 132
|
|
| DEXHc_UvrB |
cd17916 |
DEXH-box helicase domain of excinuclease ABC subunit B; Excinuclease ABC subunit B (or UvrB) ... |
166-238 |
4.89e-03 |
|
DEXH-box helicase domain of excinuclease ABC subunit B; Excinuclease ABC subunit B (or UvrB) plays a central role in nucleotide excision repair (NER). Together with other components of the NER system, like UvrA, UvrC, UvrD (helicase II) and DNA polymerase I, it recognizes and cleaves damaged DNA in a multistep ATP-dependent reaction. UvrB is critical for the second phase of damage recognition by verifying the nature of the damage and forming the pre-incision complex. Its ATPase site becomes activated in the presence of UvrA and damaged DNA, but its activity is strand destabilization via distortion of the DNA at lesion site, with very limited DNA unwinding. UvrB is a member of the DEAD-like helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350674 [Multi-domain] Cd Length: 299 Bit Score: 39.50 E-value: 4.89e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6322876 166 KPTSIQKQAIPQIIGNAGKNDffiHAQ-----TGSGKTLsyllpiisTILNMDTHVDRTsgafALVIAPTRELASQIY 238
Cdd:cd17916 8 KPAGDQPQAIAKLVEGLKRGV---KFQtllgvTGSGKTF--------TIANVIAQVNKP----TLVIAHNKTLAAQLY 70
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
487-554 |
7.55e-03 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 39.82 E-value: 7.55e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6322876 487 LHGSLSQQMRTSTLQHFARDNEAtkgkHLIMFCTDVASRGLDLPHVGSVIELDPPF--AVE----DHLHRVGRT 554
Cdd:COG0553 579 LHGGTSAEERDELVDRFQEGPEA----PVFLISLKAGGEGLNLTAADHVIHYDLWWnpAVEeqaiDRAHRIGQT 648
|
|
| |
