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Conserved domains on  [gi|330443685|ref|NP_014028|]
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dynein light intermediate chain [Saccharomyces cerevisiae S288C]

Protein Classification

dynein light intermediate chain family protein( domain architecture ID 706898)

dynein light intermediate chain (DLIC) family protein is a non-catalytic accessory component of the cytoplasmic dynein complex and may be involved in linking dynein to cargos and to adapter proteins that regulate dynein function

CATH:  3.40.50.300
Gene Ontology:  GO:0005524|GO:0045504|GO:0005868|GO:0016020
PubMed:  29515126|34014309|18466635|15037233

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DLIC super family cl25911
Dynein light intermediate chain (DLIC); This family consists of several eukaryotic dynein ...
 163-301 8.78e-04

Dynein light intermediate chain (DLIC); This family consists of several eukaryotic dynein light intermediate chain proteins. The light intermediate chains (LICs) of cytoplasmic dynein consist of multiple isoforms, which undergo post-translational modification to produce a large number of species. DLIC1 is known to be involved in assembly, organization, and function of centrosomes and mitotic spindles when bound to pericentrin. DLIC2 is a subunit of cytoplasmic dynein 2 that may play a role in maintaining Golgi organization by binding cytoplasmic dynein 2 to its Golgi-associated cargo.


The actual alignment was detected with superfamily member pfam05783:

Pssm-ID: 368612  Cd Length: 468  Bit Score: 40.60  E-value: 8.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443685  163 HIDFILQTLRSFCYFNDSSLFYicedhTEEKREEAQRLKYQELLkHFCEDRDMKDHIEMVKRSEILIPKGCDSIGLIKTV 242
Cdd:pfam05783 221 HFDFIQSHIRRFCLQYGAALIY-----TSVKEEKNLDLLYKYLV-HKIYGFPFRTPALVVEKDAVFIPAGWDNEKKIAIL 294

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 330443685  243 DERFepTEVKEQHFlarYMDFI--PTIDKIREDRKTTSGIDldklyplEVFKVNIQEELGK 301
Cdd:pfam05783 295 HENF--QTVKPEDP---YEDFIvkPPVRKLVHDKEIQAEDE-------QVFLMKQQSLLAK 343
 
Name Accession Description Interval E-value
DLIC pfam05783
Dynein light intermediate chain (DLIC); This family consists of several eukaryotic dynein ...
 163-301 8.78e-04

Dynein light intermediate chain (DLIC); This family consists of several eukaryotic dynein light intermediate chain proteins. The light intermediate chains (LICs) of cytoplasmic dynein consist of multiple isoforms, which undergo post-translational modification to produce a large number of species. DLIC1 is known to be involved in assembly, organization, and function of centrosomes and mitotic spindles when bound to pericentrin. DLIC2 is a subunit of cytoplasmic dynein 2 that may play a role in maintaining Golgi organization by binding cytoplasmic dynein 2 to its Golgi-associated cargo.


Pssm-ID: 368612  Cd Length: 468  Bit Score: 40.60  E-value: 8.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443685  163 HIDFILQTLRSFCYFNDSSLFYicedhTEEKREEAQRLKYQELLkHFCEDRDMKDHIEMVKRSEILIPKGCDSIGLIKTV 242
Cdd:pfam05783 221 HFDFIQSHIRRFCLQYGAALIY-----TSVKEEKNLDLLYKYLV-HKIYGFPFRTPALVVEKDAVFIPAGWDNEKKIAIL 294

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 330443685  243 DERFepTEVKEQHFlarYMDFI--PTIDKIREDRKTTSGIDldklyplEVFKVNIQEELGK 301
Cdd:pfam05783 295 HENF--QTVKPEDP---YEDFIvkPPVRKLVHDKEIQAEDE-------QVFLMKQQSLLAK 343
 
Name Accession Description Interval E-value
DLIC pfam05783
Dynein light intermediate chain (DLIC); This family consists of several eukaryotic dynein ...
 163-301 8.78e-04

Dynein light intermediate chain (DLIC); This family consists of several eukaryotic dynein light intermediate chain proteins. The light intermediate chains (LICs) of cytoplasmic dynein consist of multiple isoforms, which undergo post-translational modification to produce a large number of species. DLIC1 is known to be involved in assembly, organization, and function of centrosomes and mitotic spindles when bound to pericentrin. DLIC2 is a subunit of cytoplasmic dynein 2 that may play a role in maintaining Golgi organization by binding cytoplasmic dynein 2 to its Golgi-associated cargo.


Pssm-ID: 368612  Cd Length: 468  Bit Score: 40.60  E-value: 8.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443685  163 HIDFILQTLRSFCYFNDSSLFYicedhTEEKREEAQRLKYQELLkHFCEDRDMKDHIEMVKRSEILIPKGCDSIGLIKTV 242
Cdd:pfam05783 221 HFDFIQSHIRRFCLQYGAALIY-----TSVKEEKNLDLLYKYLV-HKIYGFPFRTPALVVEKDAVFIPAGWDNEKKIAIL 294

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 330443685  243 DERFepTEVKEQHFlarYMDFI--PTIDKIREDRKTTSGIDldklyplEVFKVNIQEELGK 301
Cdd:pfam05783 295 HENF--QTVKPEDP---YEDFIvkPPVRKLVHDKEIQAEDE-------QVFLMKQQSLLAK 343
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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