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Conserved domains on  [gi|6912516|ref|NP_036463|]
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mitochondrial peptide methionine sulfoxide reductase isoform a precursor [Homo sapiens]

Protein Classification

peptide-methionine (S)-S-oxide reductase( domain architecture ID 10000723)

peptide-methionine (S)-S-oxide reductase catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MsrA COG0225
Peptide methionine sulfoxide reductase MsrA [Posttranslational modification, protein turnover, ...
62-231 2.71e-101

Peptide methionine sulfoxide reductase MsrA [Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 439995  Cd Length: 177  Bit Score: 291.23  E-value: 2.71e-101
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912516   62 PEGTQMAVFGMGCFWGAERKFWVLKGVYSTQVGFAGGYTSNPTYKEVCSEKTGHAEVVRVVYQPEHMSFEELLKVFWENH 141
Cdd:COG0225   1 PAGTETATFAGGCFWCVEAVFEQLPGVISVVSGYAGGHTPNPTYEEVCSGRTGHAEAVQVTYDPAVISYEELLEVFFEIH 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912516  142 DPTQGMRQGNDHGTQYRSAIYPTSAKQMEAALSSKENYQKVLSehgfGPITTDIREGQTFYYAEDYHQQYLSKNPNG-YC 220
Cdd:COG0225  81 DPTQLNRQGNDRGTQYRSAIFYHDEEQKEIAEASIAALQASLD----GPIVTEIEPAKTFYPAEDYHQDYLAKNPNGyYC 156
                       170
                ....*....|.
gi 6912516  221 GLGGTGVSCPV 231
Cdd:COG0225 157 YRVGTGKVAKL 167
 
Name Accession Description Interval E-value
MsrA COG0225
Peptide methionine sulfoxide reductase MsrA [Posttranslational modification, protein turnover, ...
62-231 2.71e-101

Peptide methionine sulfoxide reductase MsrA [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 439995  Cd Length: 177  Bit Score: 291.23  E-value: 2.71e-101
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912516   62 PEGTQMAVFGMGCFWGAERKFWVLKGVYSTQVGFAGGYTSNPTYKEVCSEKTGHAEVVRVVYQPEHMSFEELLKVFWENH 141
Cdd:COG0225   1 PAGTETATFAGGCFWCVEAVFEQLPGVISVVSGYAGGHTPNPTYEEVCSGRTGHAEAVQVTYDPAVISYEELLEVFFEIH 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912516  142 DPTQGMRQGNDHGTQYRSAIYPTSAKQMEAALSSKENYQKVLSehgfGPITTDIREGQTFYYAEDYHQQYLSKNPNG-YC 220
Cdd:COG0225  81 DPTQLNRQGNDRGTQYRSAIFYHDEEQKEIAEASIAALQASLD----GPIVTEIEPAKTFYPAEDYHQDYLAKNPNGyYC 156
                       170
                ....*....|.
gi 6912516  221 GLGGTGVSCPV 231
Cdd:COG0225 157 YRVGTGKVAKL 167
PMSR pfam01625
Peptide methionine sulfoxide reductase; This enzyme repairs damaged proteins. Methionine ...
68-220 5.17e-93

Peptide methionine sulfoxide reductase; This enzyme repairs damaged proteins. Methionine sulfoxide in proteins is reduced to methionine.


Pssm-ID: 460270  Cd Length: 153  Bit Score: 269.64  E-value: 5.17e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912516     68 AVFGMGCFWGAERKFWVLKGVYSTQVGFAGGYTSNPTYKEVCSEKTGHAEVVRVVYQPEHMSFEELLKVFWENHDPTQGM 147
Cdd:pfam01625   2 ATFAGGCFWGVEALFERLPGVISTEVGYAGGHTENPTYEEVCSGTTGHAEAVQVVYDPEVISYEELLELFFEIHDPTTLN 81
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6912516    148 RQGNDHGTQYRSAIYPTSAKQMEAALSSKENYQKvlSEHGFGPITTDIREGQTFYYAEDYHQQYLSKNPNGYC 220
Cdd:pfam01625  82 RQGNDVGTQYRSAIFYHDEEQKEIAEASIAELQA--SGRYGKPIVTEIEPAGNFYPAEDYHQDYLEKNPNGYC 152
msrA TIGR00401
methionine-S-sulfoxide reductase; This model describes peptide methionine sulfoxide reductase ...
66-216 6.30e-81

methionine-S-sulfoxide reductase; This model describes peptide methionine sulfoxide reductase (MsrA), a repair enzyme for proteins that have been inactivated by oxidation. The enzyme from E. coli is coextensive with this model and has enzymatic activity. However, in all completed genomes in which this module is present, a second protein module, described in TIGR00357, is also found, and in several cases as part of the same polypeptide chain: N-terminal to this module in Helicobacter pylori and Haemophilus influenzae (as in PilB of Neisseria gonorrhoeae) but C-terminal to it in Treponema pallidum. PilB, containing both domains, has been shown to be important for the expression of adhesins in certain pathogens. [Protein fate, Protein modification and repair, Cellular processes, Adaptations to atypical conditions]


Pssm-ID: 129496  Cd Length: 149  Bit Score: 238.88  E-value: 6.30e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912516     66 QMAVFGMGCFWGAERKFWVLKGVYSTQVGFAGGYTSNPTYKEVCSEKTGHAEVVRVVYQPEHMSFEELLKVFWENHDPTQ 145
Cdd:TIGR00401   1 EIATFAGGCFWGTEKYFRLIPGVVSTAVGYTNGYTPNPTYEEVCSGDTGHAEAVQVTYDPKVISYEELLDVFWEIHDPTT 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6912516    146 GMRQGNDHGTQYRSAIYPTSAKQMEAALSSKENYQKvlsEHGFG-PITTDIREGQTFYYAEDYHQQYLSKNP 216
Cdd:TIGR00401  81 GNRQGNDIGTQYRSGIYYHSDAQEKAAAASKERLQA---AANYGdPIVTEIEPAENFYYAEEYHQQYLKKNP 149
PRK05550 PRK05550
bifunctional methionine sulfoxide reductase B/A protein; Provisional
63-220 4.18e-68

bifunctional methionine sulfoxide reductase B/A protein; Provisional


Pssm-ID: 235499 [Multi-domain]  Cd Length: 283  Bit Score: 210.91  E-value: 4.18e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912516    63 EGTQMAVFGMGCFWGAERKFWVLKGVYSTQVGFAGGYTSNPTYKEVCSEKTGHAEVVRVVYQPEHMSFEELLKVFWENHD 142
Cdd:PRK05550 125 YDTEEAIFAGGCFWGVEYYFKKLPGVLSVESGYTGGDTKNPTYEQVCSGTTGHAEAVRVEFDPAKISYETLLKVFFEIHD 204
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6912516   143 PTQGMRQGNDHGTQYRSAIYPTSAKQMEAAlsskENYQKVLSEHGFgPITTDIREGQTFYYAEDYHQQYLSKNPNG-YC 220
Cdd:PRK05550 205 PTQLNRQGPDIGTQYRSAIFYHDDEQKQIA----EKLIAELTKKGY-PVVTEVEAAGPFYPAEDYHQDYYEKHGKQpYC 278
 
Name Accession Description Interval E-value
MsrA COG0225
Peptide methionine sulfoxide reductase MsrA [Posttranslational modification, protein turnover, ...
62-231 2.71e-101

Peptide methionine sulfoxide reductase MsrA [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 439995  Cd Length: 177  Bit Score: 291.23  E-value: 2.71e-101
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912516   62 PEGTQMAVFGMGCFWGAERKFWVLKGVYSTQVGFAGGYTSNPTYKEVCSEKTGHAEVVRVVYQPEHMSFEELLKVFWENH 141
Cdd:COG0225   1 PAGTETATFAGGCFWCVEAVFEQLPGVISVVSGYAGGHTPNPTYEEVCSGRTGHAEAVQVTYDPAVISYEELLEVFFEIH 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912516  142 DPTQGMRQGNDHGTQYRSAIYPTSAKQMEAALSSKENYQKVLSehgfGPITTDIREGQTFYYAEDYHQQYLSKNPNG-YC 220
Cdd:COG0225  81 DPTQLNRQGNDRGTQYRSAIFYHDEEQKEIAEASIAALQASLD----GPIVTEIEPAKTFYPAEDYHQDYLAKNPNGyYC 156
                       170
                ....*....|.
gi 6912516  221 GLGGTGVSCPV 231
Cdd:COG0225 157 YRVGTGKVAKL 167
PMSR pfam01625
Peptide methionine sulfoxide reductase; This enzyme repairs damaged proteins. Methionine ...
68-220 5.17e-93

Peptide methionine sulfoxide reductase; This enzyme repairs damaged proteins. Methionine sulfoxide in proteins is reduced to methionine.


Pssm-ID: 460270  Cd Length: 153  Bit Score: 269.64  E-value: 5.17e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912516     68 AVFGMGCFWGAERKFWVLKGVYSTQVGFAGGYTSNPTYKEVCSEKTGHAEVVRVVYQPEHMSFEELLKVFWENHDPTQGM 147
Cdd:pfam01625   2 ATFAGGCFWGVEALFERLPGVISTEVGYAGGHTENPTYEEVCSGTTGHAEAVQVVYDPEVISYEELLELFFEIHDPTTLN 81
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6912516    148 RQGNDHGTQYRSAIYPTSAKQMEAALSSKENYQKvlSEHGFGPITTDIREGQTFYYAEDYHQQYLSKNPNGYC 220
Cdd:pfam01625  82 RQGNDVGTQYRSAIFYHDEEQKEIAEASIAELQA--SGRYGKPIVTEIEPAGNFYPAEDYHQDYLEKNPNGYC 152
msrA TIGR00401
methionine-S-sulfoxide reductase; This model describes peptide methionine sulfoxide reductase ...
66-216 6.30e-81

methionine-S-sulfoxide reductase; This model describes peptide methionine sulfoxide reductase (MsrA), a repair enzyme for proteins that have been inactivated by oxidation. The enzyme from E. coli is coextensive with this model and has enzymatic activity. However, in all completed genomes in which this module is present, a second protein module, described in TIGR00357, is also found, and in several cases as part of the same polypeptide chain: N-terminal to this module in Helicobacter pylori and Haemophilus influenzae (as in PilB of Neisseria gonorrhoeae) but C-terminal to it in Treponema pallidum. PilB, containing both domains, has been shown to be important for the expression of adhesins in certain pathogens. [Protein fate, Protein modification and repair, Cellular processes, Adaptations to atypical conditions]


Pssm-ID: 129496  Cd Length: 149  Bit Score: 238.88  E-value: 6.30e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912516     66 QMAVFGMGCFWGAERKFWVLKGVYSTQVGFAGGYTSNPTYKEVCSEKTGHAEVVRVVYQPEHMSFEELLKVFWENHDPTQ 145
Cdd:TIGR00401   1 EIATFAGGCFWGTEKYFRLIPGVVSTAVGYTNGYTPNPTYEEVCSGDTGHAEAVQVTYDPKVISYEELLDVFWEIHDPTT 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6912516    146 GMRQGNDHGTQYRSAIYPTSAKQMEAALSSKENYQKvlsEHGFG-PITTDIREGQTFYYAEDYHQQYLSKNP 216
Cdd:TIGR00401  81 GNRQGNDIGTQYRSGIYYHSDAQEKAAAASKERLQA---AANYGdPIVTEIEPAENFYYAEEYHQQYLKKNP 149
PRK05550 PRK05550
bifunctional methionine sulfoxide reductase B/A protein; Provisional
63-220 4.18e-68

bifunctional methionine sulfoxide reductase B/A protein; Provisional


Pssm-ID: 235499 [Multi-domain]  Cd Length: 283  Bit Score: 210.91  E-value: 4.18e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912516    63 EGTQMAVFGMGCFWGAERKFWVLKGVYSTQVGFAGGYTSNPTYKEVCSEKTGHAEVVRVVYQPEHMSFEELLKVFWENHD 142
Cdd:PRK05550 125 YDTEEAIFAGGCFWGVEYYFKKLPGVLSVESGYTGGDTKNPTYEQVCSGTTGHAEAVRVEFDPAKISYETLLKVFFEIHD 204
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6912516   143 PTQGMRQGNDHGTQYRSAIYPTSAKQMEAAlsskENYQKVLSEHGFgPITTDIREGQTFYYAEDYHQQYLSKNPNG-YC 220
Cdd:PRK05550 205 PTQLNRQGPDIGTQYRSAIFYHDDEQKQIA----EKLIAELTKKGY-PVVTEVEAAGPFYPAEDYHQDYYEKHGKQpYC 278
PRK13014 PRK13014
methionine sulfoxide reductase A; Provisional
58-217 4.77e-62

methionine sulfoxide reductase A; Provisional


Pssm-ID: 237269  Cd Length: 186  Bit Score: 192.15  E-value: 4.77e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912516    58 VEPFPEGTQMAVFGMGCFWGAERKFWVLKGVYSTQVGFAGGYTSNPTYKEVCSEKTGHAEVVRVVYQPEHMSFEELLKVF 137
Cdd:PRK13014   1 VDAAADGMETATFAGGCFWGVEGVFQHVPGVVSVVSGYSGGHVDNPTYEQVCTGTTGHAEAVQITYDPKQVSYENLLQIF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912516   138 WENHDPTQGMRQGNDHGTQYRSAIYPTSAKQMEAALSSKENYQKvlsEHGFG-PITTDIREGQTFYYAEDYHQQYLSKNP 216
Cdd:PRK13014  81 FSTHDPTQLNRQGPDRGEQYRSAIFYHDEEQKKVAEAYIAQLDE---AGIFKkPIVTPIKPYKNFYPAEDYHQDYLKKNP 157

                 .
gi 6912516   217 N 217
Cdd:PRK13014 158 T 158
PRK14018 PRK14018
bifunctional peptide-methionine (S)-S-oxide reductase MsrA/peptide-methionine (R)-S-oxide ...
73-220 7.90e-39

bifunctional peptide-methionine (S)-S-oxide reductase MsrA/peptide-methionine (R)-S-oxide reductase MsrB;


Pssm-ID: 184456 [Multi-domain]  Cd Length: 521  Bit Score: 140.78  E-value: 7.90e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912516    73 GCFWGAERKFWVLKGVYSTQVGFAGGYTSNPTYKEVCSeKTGHAEVVRVVYQPEHMSFEELLKVFWENHDPTQGMRQGND 152
Cdd:PRK14018 206 GCFWGLEAYFQRIDGVVDAVSGYANGNTKNPSYEDVYR-HSGHAETVKVTYDADKLSLDTILQYYFRVVDPTSLNKQGND 284
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6912516   153 HGTQYRSAIYPT--SAKQM-EAALSS-KENYQKvlsehgfgPITTDIREGQTFYYAEDYHQQYLSKNPNGYC 220
Cdd:PRK14018 285 TGTQYRSGVYYTdpADKAViAAALKReQQKYQL--------PLVVENEPLKNFYDAEEYHQDYLIKNPNGYC 348
PRK05528 PRK05528
peptide-methionine (S)-S-oxide reductase;
70-220 8.62e-23

peptide-methionine (S)-S-oxide reductase;


Pssm-ID: 235497  Cd Length: 156  Bit Score: 90.46  E-value: 8.62e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912516    70 FGMGCFWGAERKFWVLKGVYSTQVGFAGGYTSNptykeVCSEKTGHAEVVRVVYQPEHMSFEELLKVFWENHDPTQGMRQ 149
Cdd:PRK05528   6 FAGGCLWGVQAFFKTLPGVIHTEAGRANGRTST-----LDGPYDGYAECVKTHFDPRMVSITDLMGYLFEIIDPYSVNKQ 80
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6912516   150 GNDHGTQYRSAIYPTSAKQMEAA---LSSKENYQKVLSEhgFGPITTDIRegqtfyyAEDYHQQYLSKNPNGYC 220
Cdd:PRK05528  81 GNDVGEKYRTGIYSEVDDHLIEArqfIERREDADKIAVE--VLPLTNYVK-------SAEEHQDRLEKFPEDYC 145
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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