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Conserved domains on  [gi|9626072|ref|NP_040312|]
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E1 protein [human papillomavirus 18]

Protein Classification

replication protein E1( domain architecture ID 11476085)

replication protein E1 is an ATP-dependent DNA helicase required for initiation of viral DNA replication

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PHA02774 PHA02774
E1; Provisional
1-657 0e+00

E1; Provisional


:

Pssm-ID: 222927 [Multi-domain]  Cd Length: 613  Bit Score: 1018.28  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9626072     1 MADPEGTDGEGTGCNgWFYVQAIVDKKTGDvisdDEDENATDTGSDMVDFIDTqgtfCEQAELETAQALFHAQEVHNDAQ 80
Cdd:PHA02774   1 MADDKGTDPEEGGSG-WFLVEAEAECSDGE----DELEDLFDTGSDISDLIDD----AEVVQGGNSLALFHQQEAEEDEQ 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9626072    81 VLHVLKRKFAGgstenSPlgeRLEVDTELSPRLQEISLnSGQKKAKRRLFTISDSGYGCSEVEATQIQVTTNGEHGGNVC 160
Cdd:PHA02774  72 QIQALKRKYLS-----SP---EKSPVADLSPRLEAISL-SPRKKAKRRLFEEQDSGLGNSLEEESTDVVEEEGVESSGGG 142
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9626072   161 SGGSTEAIDNGGTegnnssvdgtsdnsnienvnpqctiaQLKDLLKVNNKQGAMLAVFKDTYGLSFTDLVRNFKSDKTTC 240
Cdd:PHA02774 143 EGGSETGQGGGNG--------------------------LVLDLLRSSNRRATLLAKFKEAFGVSFTELTRPFKSDKTCC 196
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9626072   241 TDWVTAIFGVNPTIAEGFKTLIQPFILYAHIQCLDCKWGVLILALLRYKCGKSRLTVAKGLSTLLHVPETCMLIQPPKLR 320
Cdd:PHA02774 197 NDWVVAVFGVSEELLEASKTLLQQHCDYLQIQCLTCEWGFVALYLLRFKAAKSRETVRKLLSSLLNVPEEQLLLEPPKLR 276
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9626072   321 SSVAALYWYRTGISNISEVMGDTPEWIQRLTIIQHGI-DDSNFDLSEMVQWAFDNELTDESDMAFEYALLADSNSNAAAF 399
Cdd:PHA02774 277 SVAAALFWYKKSMSNASYTHGELPEWIARQTLLSHQLaEAEQFDLSKMVQWAYDNDYTDESEIAYEYALLADEDSNAAAF 356
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9626072   400 LKSNCQAKYLKDCATMCKHYRRAQKRQMNMSQWIRFRCSKIDEGGDWRPIVQFLRYQQIEFITFLGALKSFLKGTPKKNC 479
Cdd:PHA02774 357 LKSNNQAKYVKDCATMVRHYKRAEMREMSMSQWIKKRCDKVEGEGDWKPIVKFLRYQGVEFISFLTALKDFLKGIPKKNC 436
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9626072   480 LVFCGPANTGKSYFGMSFIHFIQGAVISFVNSTSHFWLEPLTDTKVAMLDDATTTCWTYFDTYMRNALDGNPISIDRKHK 559
Cdd:PHA02774 437 LVIYGPPDTGKSMFCMSLIKFLKGKVISFVNSKSHFWLQPLADAKIALLDDATHPCWDYIDTYLRNALDGNPVSIDCKHK 516
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9626072   560 PLIQLKCPPILLTTNIHPAKDNRWPYLESRITVFEFPNAFPFDKNGNPVYEINDKNWKCFFERTWSRLDLHEEEEDADTe 639
Cdd:PHA02774 517 APVQIKCPPLLITSNIDVKAEDRYKYLHSRITVFEFPNPFPLDENGNPVFELTDANWKSFFERLWSQLDLSDQEDEGED- 595
                        650
                 ....*....|....*...
gi 9626072   640 GNPFGTFKLRAGQNHRPL 657
Cdd:PHA02774 596 GEPQRTFRCTARAANGSL 613
 
Name Accession Description Interval E-value
PHA02774 PHA02774
E1; Provisional
1-657 0e+00

E1; Provisional


Pssm-ID: 222927 [Multi-domain]  Cd Length: 613  Bit Score: 1018.28  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9626072     1 MADPEGTDGEGTGCNgWFYVQAIVDKKTGDvisdDEDENATDTGSDMVDFIDTqgtfCEQAELETAQALFHAQEVHNDAQ 80
Cdd:PHA02774   1 MADDKGTDPEEGGSG-WFLVEAEAECSDGE----DELEDLFDTGSDISDLIDD----AEVVQGGNSLALFHQQEAEEDEQ 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9626072    81 VLHVLKRKFAGgstenSPlgeRLEVDTELSPRLQEISLnSGQKKAKRRLFTISDSGYGCSEVEATQIQVTTNGEHGGNVC 160
Cdd:PHA02774  72 QIQALKRKYLS-----SP---EKSPVADLSPRLEAISL-SPRKKAKRRLFEEQDSGLGNSLEEESTDVVEEEGVESSGGG 142
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9626072   161 SGGSTEAIDNGGTegnnssvdgtsdnsnienvnpqctiaQLKDLLKVNNKQGAMLAVFKDTYGLSFTDLVRNFKSDKTTC 240
Cdd:PHA02774 143 EGGSETGQGGGNG--------------------------LVLDLLRSSNRRATLLAKFKEAFGVSFTELTRPFKSDKTCC 196
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9626072   241 TDWVTAIFGVNPTIAEGFKTLIQPFILYAHIQCLDCKWGVLILALLRYKCGKSRLTVAKGLSTLLHVPETCMLIQPPKLR 320
Cdd:PHA02774 197 NDWVVAVFGVSEELLEASKTLLQQHCDYLQIQCLTCEWGFVALYLLRFKAAKSRETVRKLLSSLLNVPEEQLLLEPPKLR 276
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9626072   321 SSVAALYWYRTGISNISEVMGDTPEWIQRLTIIQHGI-DDSNFDLSEMVQWAFDNELTDESDMAFEYALLADSNSNAAAF 399
Cdd:PHA02774 277 SVAAALFWYKKSMSNASYTHGELPEWIARQTLLSHQLaEAEQFDLSKMVQWAYDNDYTDESEIAYEYALLADEDSNAAAF 356
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9626072   400 LKSNCQAKYLKDCATMCKHYRRAQKRQMNMSQWIRFRCSKIDEGGDWRPIVQFLRYQQIEFITFLGALKSFLKGTPKKNC 479
Cdd:PHA02774 357 LKSNNQAKYVKDCATMVRHYKRAEMREMSMSQWIKKRCDKVEGEGDWKPIVKFLRYQGVEFISFLTALKDFLKGIPKKNC 436
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9626072   480 LVFCGPANTGKSYFGMSFIHFIQGAVISFVNSTSHFWLEPLTDTKVAMLDDATTTCWTYFDTYMRNALDGNPISIDRKHK 559
Cdd:PHA02774 437 LVIYGPPDTGKSMFCMSLIKFLKGKVISFVNSKSHFWLQPLADAKIALLDDATHPCWDYIDTYLRNALDGNPVSIDCKHK 516
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9626072   560 PLIQLKCPPILLTTNIHPAKDNRWPYLESRITVFEFPNAFPFDKNGNPVYEINDKNWKCFFERTWSRLDLHEEEEDADTe 639
Cdd:PHA02774 517 APVQIKCPPLLITSNIDVKAEDRYKYLHSRITVFEFPNPFPLDENGNPVFELTDANWKSFFERLWSQLDLSDQEDEGED- 595
                        650
                 ....*....|....*...
gi 9626072   640 GNPFGTFKLRAGQNHRPL 657
Cdd:PHA02774 596 GEPQRTFRCTARAANGSL 613
PPV_E1_C pfam00519
Papillomavirus helicase; This is the C-terminal ATPase/helicase domain of Papillomavirus E1 ...
359-648 0e+00

Papillomavirus helicase; This is the C-terminal ATPase/helicase domain of Papillomavirus E1 protein, a DNA helicase that is required for initiation of viral DNA replication. This protein forms a complex with the E2 protein pfam00508. The domain architecture of E1 is similar to that of the SV40 T-antigen.


Pssm-ID: 459841  Cd Length: 289  Bit Score: 536.17  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9626072    359 DSNFDLSEMVQWAFDNELTDESDMAFEYALLADSNSNAAAFLKSNCQAKYLKDCATMCKHYRRAQKRQMNMSQWIRFRCS 438
Cdd:pfam00519   1 ESTFDLSRMVQWAYDNDLQDESEIAYKYAQLAEEDSNARAFLKSNNQAKHVKDCATMVRHYKRAEMRQMSMSQWINKRCD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9626072    439 KIDEGGDWRPIVQFLRYQQIEFITFLGALKSFLKGTPKKNCLVFCGPANTGKSYFGMSFIHFIQGAVISFVNSTSHFWLE 518
Cdd:pfam00519  81 EVEGEGDWKPIVKFLRYQGVEFISFLTALKSFLRGIPKKNCLVFYGPPNTGKSLFCMSLMKFLKGKVLSFVNSKSHFWLQ 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9626072    519 PLTDTKVAMLDDATTTCWTYFDTYMRNALDGNPISIDRKHKPLIQLKCPPILLTTNIHPAKDNRWPYLESRITVFEFPNA 598
Cdd:pfam00519 161 PLAEAKVALLDDATTPCWDYIDTYLRNALDGNPVSIDAKHRAPVQIKCPPLLITSNIDVKADDRWKYLHSRIKVFHFPNE 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 9626072    599 FPFDKNGNPVYEINDKNWKCFFERTWSRLDLHEEEEDADtEGNPFGTFKL 648
Cdd:pfam00519 241 FPLKDNGNPVYQLTDENWKSFFERLWRQLDLSDPEDEGD-DGESQQTFRC 289
 
Name Accession Description Interval E-value
PHA02774 PHA02774
E1; Provisional
1-657 0e+00

E1; Provisional


Pssm-ID: 222927 [Multi-domain]  Cd Length: 613  Bit Score: 1018.28  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9626072     1 MADPEGTDGEGTGCNgWFYVQAIVDKKTGDvisdDEDENATDTGSDMVDFIDTqgtfCEQAELETAQALFHAQEVHNDAQ 80
Cdd:PHA02774   1 MADDKGTDPEEGGSG-WFLVEAEAECSDGE----DELEDLFDTGSDISDLIDD----AEVVQGGNSLALFHQQEAEEDEQ 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9626072    81 VLHVLKRKFAGgstenSPlgeRLEVDTELSPRLQEISLnSGQKKAKRRLFTISDSGYGCSEVEATQIQVTTNGEHGGNVC 160
Cdd:PHA02774  72 QIQALKRKYLS-----SP---EKSPVADLSPRLEAISL-SPRKKAKRRLFEEQDSGLGNSLEEESTDVVEEEGVESSGGG 142
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9626072   161 SGGSTEAIDNGGTegnnssvdgtsdnsnienvnpqctiaQLKDLLKVNNKQGAMLAVFKDTYGLSFTDLVRNFKSDKTTC 240
Cdd:PHA02774 143 EGGSETGQGGGNG--------------------------LVLDLLRSSNRRATLLAKFKEAFGVSFTELTRPFKSDKTCC 196
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9626072   241 TDWVTAIFGVNPTIAEGFKTLIQPFILYAHIQCLDCKWGVLILALLRYKCGKSRLTVAKGLSTLLHVPETCMLIQPPKLR 320
Cdd:PHA02774 197 NDWVVAVFGVSEELLEASKTLLQQHCDYLQIQCLTCEWGFVALYLLRFKAAKSRETVRKLLSSLLNVPEEQLLLEPPKLR 276
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9626072   321 SSVAALYWYRTGISNISEVMGDTPEWIQRLTIIQHGI-DDSNFDLSEMVQWAFDNELTDESDMAFEYALLADSNSNAAAF 399
Cdd:PHA02774 277 SVAAALFWYKKSMSNASYTHGELPEWIARQTLLSHQLaEAEQFDLSKMVQWAYDNDYTDESEIAYEYALLADEDSNAAAF 356
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9626072   400 LKSNCQAKYLKDCATMCKHYRRAQKRQMNMSQWIRFRCSKIDEGGDWRPIVQFLRYQQIEFITFLGALKSFLKGTPKKNC 479
Cdd:PHA02774 357 LKSNNQAKYVKDCATMVRHYKRAEMREMSMSQWIKKRCDKVEGEGDWKPIVKFLRYQGVEFISFLTALKDFLKGIPKKNC 436
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9626072   480 LVFCGPANTGKSYFGMSFIHFIQGAVISFVNSTSHFWLEPLTDTKVAMLDDATTTCWTYFDTYMRNALDGNPISIDRKHK 559
Cdd:PHA02774 437 LVIYGPPDTGKSMFCMSLIKFLKGKVISFVNSKSHFWLQPLADAKIALLDDATHPCWDYIDTYLRNALDGNPVSIDCKHK 516
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9626072   560 PLIQLKCPPILLTTNIHPAKDNRWPYLESRITVFEFPNAFPFDKNGNPVYEINDKNWKCFFERTWSRLDLHEEEEDADTe 639
Cdd:PHA02774 517 APVQIKCPPLLITSNIDVKAEDRYKYLHSRITVFEFPNPFPLDENGNPVFELTDANWKSFFERLWSQLDLSDQEDEGED- 595
                        650
                 ....*....|....*...
gi 9626072   640 GNPFGTFKLRAGQNHRPL 657
Cdd:PHA02774 596 GEPQRTFRCTARAANGSL 613
PPV_E1_C pfam00519
Papillomavirus helicase; This is the C-terminal ATPase/helicase domain of Papillomavirus E1 ...
359-648 0e+00

Papillomavirus helicase; This is the C-terminal ATPase/helicase domain of Papillomavirus E1 protein, a DNA helicase that is required for initiation of viral DNA replication. This protein forms a complex with the E2 protein pfam00508. The domain architecture of E1 is similar to that of the SV40 T-antigen.


Pssm-ID: 459841  Cd Length: 289  Bit Score: 536.17  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9626072    359 DSNFDLSEMVQWAFDNELTDESDMAFEYALLADSNSNAAAFLKSNCQAKYLKDCATMCKHYRRAQKRQMNMSQWIRFRCS 438
Cdd:pfam00519   1 ESTFDLSRMVQWAYDNDLQDESEIAYKYAQLAEEDSNARAFLKSNNQAKHVKDCATMVRHYKRAEMRQMSMSQWINKRCD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9626072    439 KIDEGGDWRPIVQFLRYQQIEFITFLGALKSFLKGTPKKNCLVFCGPANTGKSYFGMSFIHFIQGAVISFVNSTSHFWLE 518
Cdd:pfam00519  81 EVEGEGDWKPIVKFLRYQGVEFISFLTALKSFLRGIPKKNCLVFYGPPNTGKSLFCMSLMKFLKGKVLSFVNSKSHFWLQ 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9626072    519 PLTDTKVAMLDDATTTCWTYFDTYMRNALDGNPISIDRKHKPLIQLKCPPILLTTNIHPAKDNRWPYLESRITVFEFPNA 598
Cdd:pfam00519 161 PLAEAKVALLDDATTPCWDYIDTYLRNALDGNPVSIDAKHRAPVQIKCPPLLITSNIDVKADDRWKYLHSRIKVFHFPNE 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 9626072    599 FPFDKNGNPVYEINDKNWKCFFERTWSRLDLHEEEEDADtEGNPFGTFKL 648
Cdd:pfam00519 241 FPLKDNGNPVYQLTDENWKSFFERLWRQLDLSDPEDEGD-DGESQQTFRC 289
PPV_E1_DBD pfam20450
Papillomavirus E1, DNA-binding domain; This is the DNA-binding domain (DBD) of Papillomavirus ...
218-355 2.31e-61

Papillomavirus E1, DNA-binding domain; This is the DNA-binding domain (DBD) of Papillomavirus E1 protein, a DNA helicase that is required for initiation of viral DNA replication. This protein forms a complex with the E2 protein pfam00508 at the origin of replication (ori). This domain is found in the central region of E1 and binds DNA at specific sites of viral origin, and also binds cooperatively with E2-DBD. This domain comprises a five-stranded antiparallel beta-sheet flanked by alpha helices on each side. This domain binds originally as a dimer in which each monomer binds to one half-site of the palindromic E1 binding site, and promotes the assembly of the hexameric helicase on the ori. E1 has a domain architecture and function similar to SV40 T-antigen.


Pssm-ID: 466599  Cd Length: 139  Bit Score: 200.65  E-value: 2.31e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9626072    218 FKDTYGLSFTDLVRNFKSDKTTCTDWVTAIFGVNPTIAEGFKTLIQPFILYAHIQCLDCKWGVLILALLRYKCGKSRLTV 297
Cdd:pfam20450   1 FKEAYGVSFTELTRPFKSDKTCCGDWVVAAYGVSESLLESSKTLLQQHCTYLHVDSRACEKGSVLLLLVRFKVQKSRETV 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 9626072    298 AKGLSTLLHVPETCMLIQPPKLRSSVAALYWYRTGISNISEVMGDTPEWIQRLTIIQH 355
Cdd:pfam20450  81 QKLLTSLLNVQELQMLLEPPKLRSVAAALFWYKRSMSSGTFTHGETPEWIAQQTLITH 138
PPV_E1_N pfam00524
E1 Protein, N terminal domain;
1-141 1.17e-30

E1 Protein, N terminal domain;


Pssm-ID: 278925  Cd Length: 121  Bit Score: 116.44  E-value: 1.17e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9626072      1 MADPEGTDG-EGTGCNGWFYVQAivdkKTGDVISDDEDENATDTgSDMVDFID-TQGTfceqaeletAQALFHAQEVHND 78
Cdd:pfam00524   1 MADPKGTDPlDDCGGNGWFLVEA----DCSDGDNDEESENDSNV-SDLVDDAVqVQGN---------SLALFQAQEAEEC 66
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 9626072     79 AQVLHVLKRKFAggsteNSPLGERLevdTELSPRLQEISLNSGQKKAKRRLFTISDSGYGCSE 141
Cdd:pfam00524  67 EKALQVLKRKYL-----DSPLSRDV---AELSPRLQAISLTKQSKAAKRRLFGTDDSGIGESL 121
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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