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Conserved domains on  [gi|151101459|ref|NP_055746|]
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serine/threonine-protein phosphatase 6 regulatory subunit 1 [Homo sapiens]

Protein Classification

SAPS family protein( domain architecture ID 10517350)

SAPS (SIT4-associating proteins) family protein

Gene Ontology:  GO:0019888|GO:0043666
PubMed:  8649382

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SAPS pfam04499
SIT4 phosphatase-associated protein; This family includes a conserved region from a group of ...
 128-519 5.52e-152

SIT4 phosphatase-associated protein; This family includes a conserved region from a group of yeast proteins that associate with the SIT4 phosphatase. This association is required for SIT4's role in G1 cyclin transcription and for bud formation. This family also includes homologous regions from other eukaryotes.


:

Pssm-ID: 398279  Cd Length: 383  Bit Score: 451.69  E-value: 5.52e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459  128 MGILINRKTDQLVSFLRKKDDFVDLLLQHIGTSAIMDLLLRLLTCVErPQLRQDVVNWLNEEKIVQRLIEQIHPSKDENQ 207
Cdd:pfam04499   1 NENLLDRKTDQMIEFIRKQENFVDKFLKHIDTPAIMDLLLKLISTDK-PELPTGVIEWLNEQNLIPKLLDLLSPSYDEDI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459  208 HSNASQSLCDIIRLSREQMIQVQDSPEPDQLLATLEKQETIEQLLSNMFEGeQSQSVIVSGIQVLLTLLEPRRPRSESVT 287
Cdd:pfam04499  80 QSNASDFLKAIITISRNAPLQLQSSIGPNELTRELVSEESVEKLLDNMLKG-KSGSALVNGVGIIIELIRKNNSDYDPVQ 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459  288 VNSFfssvdgQLELLAQGALESTVSSVgALHALRPRLSCFHQLLLEPPKLEPLQMTWGMLAPPLGNTRLHVVKLLASALS 367
Cdd:pfam04499 159 LLYT------TLEEHPPSDRDPIYLGH-LLRAFSPHLPDFHQLLLDPPKDSPLQTTLGVLIEPLGFERFKIVELIAELLH 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459  368 ANDAALTHE---------LLALDVPNTMLDLFFHYVFNNFLHAQVEGCVSTMLSlgpppdSSPETPIQNPVVKHLLQQCR 438
Cdd:pfam04499 232 CSNMSLLNEkkgeklkikLVDLGIIPTILDLFFKYPWNNFLHNVVEDIIQQILN------GPMDFSYNSFLVVDLFTDCN 305

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459  439 LVERILTSWEENDRVQCAGGPRKGYMGHLTRVAGALVQNTEKGPNAEQLRQLLKELpseQQEQWEAFVSGPLAETNKKNM 518
Cdd:pfam04499 306 LTQRILEGQKESDRFQAEKGPRLGYMGHLTLIAEEVVKFSEKYPPELISPDILEIL---ENEEWEEYVEETLEETRERYN 382


                  .
gi 151101459  519 V 519
Cdd:pfam04499 383 V 383
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 688-879 1.07e-07

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 56.10  E-value: 1.07e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459  688 GCAARGGATPLSYPSPGPQPPGPSWTATFDPVPTDAPTSPRvsgEEELHTGPPAPQGPLSVPQGLPTQSLA-SPPARDAL 766
Cdd:PHA03247 2671 GRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPA---PHALVSATPLPPGPAAARQASPALPAApAPPAVPAG 2747

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459  767 QLRSQDPTPPSAPQEATEGSKVTEPSAPC---QALVSIGDLQATFHGIRSAPSSSDSAtrDPSTSVPASGAHQPPQTTEG 843
Cdd:PHA03247 2748 PATPGGPARPARPPTTAGPPAPAPPAAPAagpPRRLTRPAVASLSESRESLPSPWDPA--DPPAAVLAPAAALPPAASPA 2825

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 151101459  844 EKSPEPLGlpQSQSAQALTPPPIPNGSAPEGPASPG 879
Cdd:PHA03247 2826 GPLPPPTS--AQPTAPPPPPGPPPPSLPLGGSVAPG 2859
 
Name Accession Description Interval E-value
SAPS pfam04499
SIT4 phosphatase-associated protein; This family includes a conserved region from a group of ...
 128-519 5.52e-152

SIT4 phosphatase-associated protein; This family includes a conserved region from a group of yeast proteins that associate with the SIT4 phosphatase. This association is required for SIT4's role in G1 cyclin transcription and for bud formation. This family also includes homologous regions from other eukaryotes.


Pssm-ID: 398279  Cd Length: 383  Bit Score: 451.69  E-value: 5.52e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459  128 MGILINRKTDQLVSFLRKKDDFVDLLLQHIGTSAIMDLLLRLLTCVErPQLRQDVVNWLNEEKIVQRLIEQIHPSKDENQ 207
Cdd:pfam04499   1 NENLLDRKTDQMIEFIRKQENFVDKFLKHIDTPAIMDLLLKLISTDK-PELPTGVIEWLNEQNLIPKLLDLLSPSYDEDI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459  208 HSNASQSLCDIIRLSREQMIQVQDSPEPDQLLATLEKQETIEQLLSNMFEGeQSQSVIVSGIQVLLTLLEPRRPRSESVT 287
Cdd:pfam04499  80 QSNASDFLKAIITISRNAPLQLQSSIGPNELTRELVSEESVEKLLDNMLKG-KSGSALVNGVGIIIELIRKNNSDYDPVQ 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459  288 VNSFfssvdgQLELLAQGALESTVSSVgALHALRPRLSCFHQLLLEPPKLEPLQMTWGMLAPPLGNTRLHVVKLLASALS 367
Cdd:pfam04499 159 LLYT------TLEEHPPSDRDPIYLGH-LLRAFSPHLPDFHQLLLDPPKDSPLQTTLGVLIEPLGFERFKIVELIAELLH 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459  368 ANDAALTHE---------LLALDVPNTMLDLFFHYVFNNFLHAQVEGCVSTMLSlgpppdSSPETPIQNPVVKHLLQQCR 438
Cdd:pfam04499 232 CSNMSLLNEkkgeklkikLVDLGIIPTILDLFFKYPWNNFLHNVVEDIIQQILN------GPMDFSYNSFLVVDLFTDCN 305

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459  439 LVERILTSWEENDRVQCAGGPRKGYMGHLTRVAGALVQNTEKGPNAEQLRQLLKELpseQQEQWEAFVSGPLAETNKKNM 518
Cdd:pfam04499 306 LTQRILEGQKESDRFQAEKGPRLGYMGHLTLIAEEVVKFSEKYPPELISPDILEIL---ENEEWEEYVEETLEETRERYN 382


                  .
gi 151101459  519 V 519
Cdd:pfam04499 383 V 383
PHA03247 PHA03247
large tegument protein UL36; Provisional
 688-879 1.07e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 56.10  E-value: 1.07e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459  688 GCAARGGATPLSYPSPGPQPPGPSWTATFDPVPTDAPTSPRvsgEEELHTGPPAPQGPLSVPQGLPTQSLA-SPPARDAL 766
Cdd:PHA03247 2671 GRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPA---PHALVSATPLPPGPAAARQASPALPAApAPPAVPAG 2747

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459  767 QLRSQDPTPPSAPQEATEGSKVTEPSAPC---QALVSIGDLQATFHGIRSAPSSSDSAtrDPSTSVPASGAHQPPQTTEG 843
Cdd:PHA03247 2748 PATPGGPARPARPPTTAGPPAPAPPAAPAagpPRRLTRPAVASLSESRESLPSPWDPA--DPPAAVLAPAAALPPAASPA 2825

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 151101459  844 EKSPEPLGlpQSQSAQALTPPPIPNGSAPEGPASPG 879
Cdd:PHA03247 2826 GPLPPPTS--AQPTAPPPPPGPPPPSLPLGGSVAPG 2859
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 718-875 2.22e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 45.14  E-value: 2.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459  718 PVPTDAPTSPRVSGEEELHTGPPAPQGPLSVPQGLP--------TQSLASPpardaLQLRSQDPT--PPSAPQEATEGSK 787
Cdd:pfam03154 177 QSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPatsqppnqTQSTAAP-----HTLIQQTPTlhPQRLPSPHPPLQP 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459  788 VTEPSAPCQalVSIGDL-QATFHG-IRSAPSSSDSATRDPSTSVPASGAHQPPQTTEGEKSPEPLGLPQSQSAQAL-TPP 864
Cdd:pfam03154 252 MTQPPPPSQ--VSPQPLpQPSLHGqMPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIhTPP 329

                         170
                  ....*....|.
gi 151101459  865 PIPNGSAPEGP 875
Cdd:pfam03154 330 SQSQLQSQQPP 340
 
Name Accession Description Interval E-value
SAPS pfam04499
SIT4 phosphatase-associated protein; This family includes a conserved region from a group of ...
 128-519 5.52e-152

SIT4 phosphatase-associated protein; This family includes a conserved region from a group of yeast proteins that associate with the SIT4 phosphatase. This association is required for SIT4's role in G1 cyclin transcription and for bud formation. This family also includes homologous regions from other eukaryotes.


Pssm-ID: 398279  Cd Length: 383  Bit Score: 451.69  E-value: 5.52e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459  128 MGILINRKTDQLVSFLRKKDDFVDLLLQHIGTSAIMDLLLRLLTCVErPQLRQDVVNWLNEEKIVQRLIEQIHPSKDENQ 207
Cdd:pfam04499   1 NENLLDRKTDQMIEFIRKQENFVDKFLKHIDTPAIMDLLLKLISTDK-PELPTGVIEWLNEQNLIPKLLDLLSPSYDEDI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459  208 HSNASQSLCDIIRLSREQMIQVQDSPEPDQLLATLEKQETIEQLLSNMFEGeQSQSVIVSGIQVLLTLLEPRRPRSESVT 287
Cdd:pfam04499  80 QSNASDFLKAIITISRNAPLQLQSSIGPNELTRELVSEESVEKLLDNMLKG-KSGSALVNGVGIIIELIRKNNSDYDPVQ 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459  288 VNSFfssvdgQLELLAQGALESTVSSVgALHALRPRLSCFHQLLLEPPKLEPLQMTWGMLAPPLGNTRLHVVKLLASALS 367
Cdd:pfam04499 159 LLYT------TLEEHPPSDRDPIYLGH-LLRAFSPHLPDFHQLLLDPPKDSPLQTTLGVLIEPLGFERFKIVELIAELLH 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459  368 ANDAALTHE---------LLALDVPNTMLDLFFHYVFNNFLHAQVEGCVSTMLSlgpppdSSPETPIQNPVVKHLLQQCR 438
Cdd:pfam04499 232 CSNMSLLNEkkgeklkikLVDLGIIPTILDLFFKYPWNNFLHNVVEDIIQQILN------GPMDFSYNSFLVVDLFTDCN 305

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459  439 LVERILTSWEENDRVQCAGGPRKGYMGHLTRVAGALVQNTEKGPNAEQLRQLLKELpseQQEQWEAFVSGPLAETNKKNM 518
Cdd:pfam04499 306 LTQRILEGQKESDRFQAEKGPRLGYMGHLTLIAEEVVKFSEKYPPELISPDILEIL---ENEEWEEYVEETLEETRERYN 382


                  .
gi 151101459  519 V 519
Cdd:pfam04499 383 V 383
PHA03247 PHA03247
large tegument protein UL36; Provisional
 688-879 1.07e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 56.10  E-value: 1.07e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459  688 GCAARGGATPLSYPSPGPQPPGPSWTATFDPVPTDAPTSPRvsgEEELHTGPPAPQGPLSVPQGLPTQSLA-SPPARDAL 766
Cdd:PHA03247 2671 GRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPA---PHALVSATPLPPGPAAARQASPALPAApAPPAVPAG 2747

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459  767 QLRSQDPTPPSAPQEATEGSKVTEPSAPC---QALVSIGDLQATFHGIRSAPSSSDSAtrDPSTSVPASGAHQPPQTTEG 843
Cdd:PHA03247 2748 PATPGGPARPARPPTTAGPPAPAPPAAPAagpPRRLTRPAVASLSESRESLPSPWDPA--DPPAAVLAPAAALPPAASPA 2825

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 151101459  844 EKSPEPLGlpQSQSAQALTPPPIPNGSAPEGPASPG 879
Cdd:PHA03247 2826 GPLPPPTS--AQPTAPPPPPGPPPPSLPLGGSVAPG 2859
PHA03247 PHA03247
large tegument protein UL36; Provisional
 714-881 3.64e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.56  E-value: 3.64e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459  714 ATFDPVPTDAPTSPRVSGEEELHTGPPAPQGPLS-----VPQGLPTQSLASPP-------------------------AR 763
Cdd:PHA03247 2735 LPAAPAPPAVPAGPATPGGPARPARPPTTAGPPApappaAPAAGPPRRLTRPAvaslsesreslpspwdpadppaavlAP 2814

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459  764 DALQLRSQDPTPPSAPQEATEGSKVTEPSAPCQALVSIGDLQATFHGI-RSAPSSSDSATRDPSTSVPASGAHQPPQTte 842
Cdd:PHA03247 2815 AAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVrRRPPSRSPAAKPAAPARPPVRRLARPAVS-- 2892

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 151101459  843 geKSPEPLGLPQSQSAQALTP-PPIPNGSAPEGPASPGSQ 881
Cdd:PHA03247 2893 --RSTESFALPPDQPERPPQPqAPPPPQPQPQPPPPPQPQ 2930
PHA03247 PHA03247
large tegument protein UL36; Provisional
 717-878 1.42e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.63  E-value: 1.42e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459  717 DPVPTDAPTSPRVSGEEELHTGPPAPQGPLSVPQGLPTQSLASPPARDALQLRS-------QDPTPPSAPQEATEGSKVT 789
Cdd:PHA03247 2620 DTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAaqassppQRPRRRAARPTVGSLTSLA 2699

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459  790 EPSAP-------CQALVSIGDLQAtfhGIRSAPSSSDSATRDPSTSVPASGAHQP--------PQTTEGEKSPEPLGLPQ 854
Cdd:PHA03247 2700 DPPPPpptpepaPHALVSATPLPP---GPAAARQASPALPAAPAPPAVPAGPATPggparparPPTTAGPPAPAPPAAPA 2776

                         170       180
                  ....*....|....*....|....
gi 151101459  855 SQSAQALTPPPIPNgSAPEGPASP 878
Cdd:PHA03247 2777 AGPPRRLTRPAVAS-LSESRESLP 2799
PHA03247 PHA03247
large tegument protein UL36; Provisional
 718-878 1.25e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.55  E-value: 1.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459  718 PVPTDAPTSPRVSGEEELHTGPP------APQGPLSVPQGLPTQSLASPPARDALQLRSQDPTPPSAPQEATEGSKVTEP 791
Cdd:PHA03247  257 PPPVVGEGADRAPETARGATGPPpppeaaAPNGAAAPPDGVWGAALAGAPLALPAPPDPPPPAPAGDAEEEDDEDGAMEV 336

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459  792 SAPC---QALVSIG----------------DLQATFHGIRSA--PSSSDSATRDPSTSVPAS--GAHQPPQTTEGEKS-- 846
Cdd:PHA03247  337 VSPLprpRQHYPLGfpkrrrptwtppssleDLSAGRHHPKRAslPTRKRRSARHAATPFARGpgGDDQTRPAAPVPASvp 416

                         170       180       190
                  ....*....|....*....|....*....|...
gi 151101459  847 -PEPLGLPQSQSAQALTPPPIPNGSAPEGPASP 878
Cdd:PHA03247  417 tPAPTPVPASAPPPPATPLPSAEPGSDDGPAPP 449
PHA03247 PHA03247
large tegument protein UL36; Provisional
 718-880 2.95e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.01  E-value: 2.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459  718 PVPTDAPTSPRVSGEEELHTGPP---APQGPLSVPQGLPTQSLASPPARDALQLRSQDPTPPSAPQEATEGSKVTEPSAP 794
Cdd:PHA03247 2571 PRPAPRPSEPAVTSRARRPDAPPqsaRPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPE 2650

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459  795 CQALVSIG-----DLQATFHGIRSAPSSSDSATRDPSTSVP----ASGAHQPPQTTEGEKSPEPL--GLP-------QSQ 856
Cdd:PHA03247 2651 RPRDDPAPgrvsrPRRARRLGRAAQASSPPQRPRRRAARPTvgslTSLADPPPPPPTPEPAPHALvsATPlppgpaaARQ 2730

                         170       180
                  ....*....|....*....|....
gi 151101459  857 SAQALTPPPIPNgSAPEGPASPGS 880
Cdd:PHA03247 2731 ASPALPAAPAPP-AVPAGPATPGG 2753
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 718-876 5.81e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 46.90  E-value: 5.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459 718 PVPTDAPTSPRVSGEeelhTGPPAPQGPLSVPQGLPTQSLASPPARDALQLRSQDPTPPSAPQEATEGSKVTEPSAPcqa 797
Cdd:PRK07764 609 PEEAARPAAPAAPAA----PAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAP--- 681

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 151101459 798 lvsigdlqatfhgirsAPSSSDSATRDPSTSVPASGAHQPPQTTEGEKSPEPLGLPQSQSAQALTPPPIPNGSAPEGPA 876
Cdd:PRK07764 682 ----------------PPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPE 744
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
738-880 8.68e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 46.38  E-value: 8.68e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459 738 GPPAPQGPLSVPQGLPTQSLASPPARDALQLRSQDPTPPSAPQEATEGSKVTEPSAPCQALVSigdlqatfhgiRSAPS- 816
Cdd:PRK07003 366 GAPGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPA-----------APAPPa 434

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 151101459 817 SSDSATR---DPSTSVPASGAHQPPQTTEGEKSPEPLGLPQSQSAQAL-TPPPIPNGSAPEGPASPGS 880
Cdd:PRK07003 435 TADRGDDaadGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASdAPPDAAFEPAPRAAAPSAA 502
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 718-875 2.22e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 45.14  E-value: 2.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459  718 PVPTDAPTSPRVSGEEELHTGPPAPQGPLSVPQGLP--------TQSLASPpardaLQLRSQDPT--PPSAPQEATEGSK 787
Cdd:pfam03154 177 QSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPatsqppnqTQSTAAP-----HTLIQQTPTlhPQRLPSPHPPLQP 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459  788 VTEPSAPCQalVSIGDL-QATFHG-IRSAPSSSDSATRDPSTSVPASGAHQPPQTTEGEKSPEPLGLPQSQSAQAL-TPP 864
Cdd:pfam03154 252 MTQPPPPSQ--VSPQPLpQPSLHGqMPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIhTPP 329

                         170
                  ....*....|.
gi 151101459  865 PIPNGSAPEGP 875
Cdd:pfam03154 330 SQSQLQSQQPP 340
PHA03378 PHA03378
EBNA-3B; Provisional
 693-877 2.86e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 44.67  E-value: 2.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459 693 GGATPLSYPSPGPQPPGPSWTAT----FDPVPTDAPTSPRVSGEEELHTGPPAPQGPLSVPQGLPTqslaspPARdalql 768
Cdd:PHA03378 647 VFPTPHQPPQVEITPYKPTWTQIghipYQPSPTGANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPG------RAQ----- 715

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459 769 RSQDPTPPSAPQEATEGSKVTEPSAPCQAlvsigdlqatfhgirSAPSSSDSATRDPSTsvpASGAHQPPQTTEGEKSPE 848
Cdd:PHA03378 716 RPAAATGRARPPAAAPGRARPPAAAPGRA---------------RPPAAAPGRARPPAA---APGRARPPAAAPGAPTPQ 777

                        170       180       190
                 ....*....|....*....|....*....|...
gi 151101459 849 PL----GLPQSQSAQALTPPPIPNGsapeGPAS 877
Cdd:PHA03378 778 PPpqapPAPQQRPRGAPTPQPPPQA----GPTS 806
PTZ00249 PTZ00249
variable surface protein Vir28; Provisional
 718-863 3.03e-04

variable surface protein Vir28; Provisional


Pssm-ID: 140276 [Multi-domain]  Cd Length: 516  Bit Score: 44.25  E-value: 3.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459 718 PVPTDAPTSPRVSGEEELHTGPPAPQGpLSVPQ--GLP-----TQSLASPPARDALQLRS-QDPTPPSapqeategskVT 789
Cdd:PTZ00249 239 PPKHISFSSPHAHGRPPVETRPPNPVS-VSSPQahGRHpgethTPPLVTVPSSKAHDRNPvQTPTPTS----------VS 307

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 151101459 790 EPSAPCQALvsigDLQAtfhGIRSAPSSSDSATRDPST-----SVPASGAHQPPQTTEGEKSPEPLGLPQSQSAQALTP 863
Cdd:PTZ00249 308 GYSSQAKGL----EKQA---GGESERTSSVPSEQFPLPlpvllPLGQSGPLESSESEETDEYAGPKGLPEPELELVELQ 379
PHA03247 PHA03247
large tegument protein UL36; Provisional
 720-878 3.88e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.54  E-value: 3.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459  720 PTDAPTSPR----VSGEEELHT----GPPAPQGPLSVP----QGLPTQSLASPPARDALQLRSQDPTPPsaPQEATEGSK 787
Cdd:PHA03247 2524 PVGEPVHPRmltwIRGLEELASddagDPPPPLPPAAPPaapdRSVPPPRPAPRPSEPAVTSRARRPDAP--PQSARPRAP 2601

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459  788 VTEPSAPCQALvsigdlqatfhgiRSAPSSSDSATRDPSTSVPASGAHQP--------PQTTEGEKSPEPLGLPQSQSAQ 859
Cdd:PHA03247 2602 VDDRGDPRGPA-------------PPSPLPPDTHAPDPPPPSPSPAANEPdphppptvPPPERPRDDPAPGRVSRPRRAR 2668

                         170
                  ....*....|....*....
gi 151101459  860 ALTPPPIPNgSAPEGPASP 878
Cdd:PHA03247 2669 RLGRAAQAS-SPPQRPRRR 2686
PHA03195 PHA03195
tegument protein VP11/12; Provisional
 742-875 6.85e-04

tegument protein VP11/12; Provisional


Pssm-ID: 177556  Cd Length: 746  Bit Score: 43.46  E-value: 6.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459 742 PQGPLSVPQGLPT----------------QSLASPPaRDALQLRSQDPTPPSAPQEATEGSKVTEPSAPCQALVSIGDLQ 805
Cdd:PHA03195 441 PQGPLPAPPNSKTrgtfrrprpgsvrgsrQLPASPP-SNIVSPRTNPAAEGSTAAKNGQGAETIQVRSSGEFNDCIWYLN 519

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 151101459 806 ATFHGIRSAPSSSDSATRD----PSTSVPASgahqPPQTTEGEKSPEPLGLPQSQSAQALTPPPIPNGSAPEGP 875
Cdd:PHA03195 520 GAYPHQRSDSSSSDNSTCSstetQYITLPST----PSPTGEVVYTNPLLGPDEEVDASPQPVDPVSDYSAPKNP 589
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 736-880 2.34e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.51  E-value: 2.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459 736 HTGPPAPQGPLSVPQGLPTQSLASPPARDALQLRSQDPTPPSAPQEATEGSkvtepsapcqalvsigdlqatfhgirsAP 815
Cdd:PRK07764 390 GAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPA---------------------------PP 442

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 151101459 816 SSSDSATRDPSTSVPASGAHQPPQTTEGEKSPEPLGLPQSQSAQALTPPPIPNGSAPEGPASPGS 880
Cdd:PRK07764 443 SPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGAD 507
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
716-879 2.89e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.40  E-value: 2.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459 716 FDPVPTDAPTSPRVSGEEELHTGPPAPQGPLSVpqglpTQSLASPPARDAlqlrsqdPTPPSAPQEATEGSKVTEPSAPC 795
Cdd:PRK12323 363 FRPGQSGGGAGPATAAAAPVAQPAPAAAAPAAA-----APAPAAPPAAPA-------AAPAAAAAARAVAAAPARRSPAP 430

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459 796 QALVSIGDLQATFHGIRSAPSSSDSATRDPSTSVPASGAHQPPQTtegEKSPEPLGLPQSQSAQALTPPPiPNGSAPEGP 875
Cdd:PRK12323 431 EALAAARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAA---AAAAPARAAPAAAPAPADDDPP-PWEELPPEF 506


                 ....
gi 151101459 876 ASPG 879
Cdd:PRK12323 507 ASPA 510
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 737-881 4.11e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.74  E-value: 4.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459 737 TGPPAPQGPLSVPQGL--PTQSLASPPARDALQLRSQDPTPPSAPQEATEGSKVTEPSAPCQALVSIGDLQATFHGIRSA 814
Cdd:PRK07764 598 EGPPAPASSGPPEEAArpAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAA 677

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459 815 PSSS-----DSATRDPSTSVPASGAHQPPQTTEGEKSPEPLGLPQSQSAQALTP-------------------------- 863
Cdd:PRK07764 678 PAAPppapaPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPspaaddpvplppepddppdpagapaq 757

                        170       180
                 ....*....|....*....|..
gi 151101459 864 ----PPIPNGSAPEGPASPGSQ 881
Cdd:PRK07764 758 ppppPAPAPAAAPAAAPPPSPP 779
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
713-877 4.74e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 40.60  E-value: 4.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459 713 TATFDPVPTDAPTSPRVSGeeelhtGPPAPQGPLSVPQGLPTQSLAsPPARDAlQLRSQDPTPPSAPQEATEGSKVTEPS 792
Cdd:PRK07003 386 RAAAAVGASAVPAVTAVTG------AAGAALAPKAAAAAAATRAEA-PPAAPA-PPATADRGDDAADGDAPVPAKANARA 457

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459 793 APCQALVSIGDLQATFHGIRSAPSSSdsaTRDPSTSVPASGAHQP-PQTTEGEKSPEPLGLPQSQSAQALTPPPIPNGSA 871
Cdd:PRK07003 458 SADSRCDERDAQPPADSGSASAPASD---APPDAAFEPAPRAAAPsAATPAAVPDARAPAAASREDAPAAAAPPAPEARP 534


                 ....*.
gi 151101459 872 PEGPAS 877
Cdd:PRK07003 535 PTPAAA 540
PHA03247 PHA03247
large tegument protein UL36; Provisional
 690-794 6.62e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.31  E-value: 6.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459  690 AARGGATPLSYPSPGPQPPGPSWTAtfdPVPTDAPTSPRVsgeeeLHTGPPAPQGPLSVPQGLPTQSLASPPARD--ALQ 767
Cdd:PHA03247  387 SARHAATPFARGPGGDDQTRPAAPV---PASVPTPAPTPV-----PASAPPPPATPLPSAEPGSDDGPAPPPERQppAPA 458

                          90       100
                  ....*....|....*....|....*..
gi 151101459  768 LRSQDPTPPSAPQEATEGSKVTEPSAP 794
Cdd:PHA03247  459 TEPAPDDPDDATRKALDALRERRPPEP 485
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 719-873 7.86e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.14  E-value: 7.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459  719 VPTDAPTSPRVSGEEEL--HTGPPAPQGPLSV-PQGlptQSLASPPARDALQLRSQDPTPPSA--PQEATEGSKVTEPSA 793
Cdd:pfam03154 386 MNSNLPPPPALKPLSSLstHHPPSAHPPPLQLmPQS---QQLPPPPAQPPVLTQSQSLPPPAAshPPTSGLHQVPSQSPF 462

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459  794 PCQALVSIGDLQAT-FHGIRSAPSSSDSATRDPSTSVPASGAHQPPQTTEGEKSPEPLGLPQSQSAQALTPPPIPNGSAP 872
Cdd:pfam03154 463 PQHPFVPGGPPPITpPSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPPVQIKEEALDEAEEPESPPPPPRSPSP 542


                  .
gi 151101459  873 E 873
Cdd:pfam03154 543 E 543
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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