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Conserved domains on  [gi|21361794|ref|NP_060918|]
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cullin-associated NEDD8-dissociated protein 1 isoform 1 [Homo sapiens]

Protein Classification

HEAT_EZ and TIP120 domain-containing protein( domain architecture ID 10607804)

HEAT_EZ and TIP120 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIP120 pfam08623
TATA-binding protein interacting (TIP20); TIP120 (also known as cullin-associated and ...
 1040-1202 6.80e-85

TATA-binding protein interacting (TIP20); TIP120 (also known as cullin-associated and neddylation-dissociated protein 1) is a TATA binding protein interacting protein that enhances transcription.


:

Pssm-ID: 430111  Cd Length: 165  Bit Score: 272.86  E-value: 6.80e-85
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361794   1040 LIRDLLDTVLPHLYNETKVRKELIREVEMGPFKHTVDDGLDIRKAAFECMYTLLDSCLDRLDIFEFLNHVEDGLKDHYDI 1119
Cdd:pfam08623    1 LILPLLDQLLPLLYAETKVKPELIREVQMGPFKHKVDDGLELRKAAYECLYTLLDTCLDRLDISEFLDRVIAGLSDEHDI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361794   1120 KMLTFLMLVRLSTLCPSAVLQRLDRLVEPLRATCTTKVKANSVKQEFEKQDELKRSAMRAVAAL-LTIPEAEKS-PLMSE 1197
Cdd:pfam08623   81 KMLCNLMLIKLVVLAPDEVLRRLDSLVEPLRKTLSKKLKENAVKQELEKQEELIRSVLRASAALnSKIPGAEKShPKWNE 160


                   ....*
gi 21361794   1198 FQSQI 1202
Cdd:pfam08623  161 FVEWV 165
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 149-202 4.30e-06

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


:

Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 45.05  E-value: 4.30e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 21361794    149 SVQLEALDIMADMLSRQGGLLVNFHPSILTCLLPQLTSPRLAVRKRTIIALGHL 202
Cdd:pfam13513    2 RVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
 
Name Accession Description Interval E-value
TIP120 pfam08623
TATA-binding protein interacting (TIP20); TIP120 (also known as cullin-associated and ...
 1040-1202 6.80e-85

TATA-binding protein interacting (TIP20); TIP120 (also known as cullin-associated and neddylation-dissociated protein 1) is a TATA binding protein interacting protein that enhances transcription.


Pssm-ID: 430111  Cd Length: 165  Bit Score: 272.86  E-value: 6.80e-85
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361794   1040 LIRDLLDTVLPHLYNETKVRKELIREVEMGPFKHTVDDGLDIRKAAFECMYTLLDSCLDRLDIFEFLNHVEDGLKDHYDI 1119
Cdd:pfam08623    1 LILPLLDQLLPLLYAETKVKPELIREVQMGPFKHKVDDGLELRKAAYECLYTLLDTCLDRLDISEFLDRVIAGLSDEHDI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361794   1120 KMLTFLMLVRLSTLCPSAVLQRLDRLVEPLRATCTTKVKANSVKQEFEKQDELKRSAMRAVAAL-LTIPEAEKS-PLMSE 1197
Cdd:pfam08623   81 KMLCNLMLIKLVVLAPDEVLRRLDSLVEPLRKTLSKKLKENAVKQELEKQEELIRSVLRASAALnSKIPGAEKShPKWNE 160


                   ....*
gi 21361794   1198 FQSQI 1202
Cdd:pfam08623  161 FVEWV 165
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 149-202 4.30e-06

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 45.05  E-value: 4.30e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 21361794    149 SVQLEALDIMADMLSRQGGLLVNFHPSILTCLLPQLTSPRLAVRKRTIIALGHL 202
Cdd:pfam13513    2 RVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
 
Name Accession Description Interval E-value
TIP120 pfam08623
TATA-binding protein interacting (TIP20); TIP120 (also known as cullin-associated and ...
 1040-1202 6.80e-85

TATA-binding protein interacting (TIP20); TIP120 (also known as cullin-associated and neddylation-dissociated protein 1) is a TATA binding protein interacting protein that enhances transcription.


Pssm-ID: 430111  Cd Length: 165  Bit Score: 272.86  E-value: 6.80e-85
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361794   1040 LIRDLLDTVLPHLYNETKVRKELIREVEMGPFKHTVDDGLDIRKAAFECMYTLLDSCLDRLDIFEFLNHVEDGLKDHYDI 1119
Cdd:pfam08623    1 LILPLLDQLLPLLYAETKVKPELIREVQMGPFKHKVDDGLELRKAAYECLYTLLDTCLDRLDISEFLDRVIAGLSDEHDI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361794   1120 KMLTFLMLVRLSTLCPSAVLQRLDRLVEPLRATCTTKVKANSVKQEFEKQDELKRSAMRAVAAL-LTIPEAEKS-PLMSE 1197
Cdd:pfam08623   81 KMLCNLMLIKLVVLAPDEVLRRLDSLVEPLRKTLSKKLKENAVKQELEKQEELIRSVLRASAALnSKIPGAEKShPKWNE 160


                   ....*
gi 21361794   1198 FQSQI 1202
Cdd:pfam08623  161 FVEWV 165
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 149-202 4.30e-06

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 45.05  E-value: 4.30e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 21361794    149 SVQLEALDIMADMLSRQGGLLVNFHPSILTCLLPQLTSPRLAVRKRTIIALGHL 202
Cdd:pfam13513    2 RVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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