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Conserved domains on  [gi|1937903927|ref|NP_062219|]
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urea transporter 1 [Rattus norvegicus]

Protein Classification

urea transporter( domain architecture ID 10505473)

urea transporter is an integral membrane protein that facilitates the rapid and passive diffusion of urea down its concentration gradient

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
UT pfam03253
Urea transporter; Members of this family transport urea across membranes. The family includes ...
56-340 2.39e-113

Urea transporter; Members of this family transport urea across membranes. The family includes a bacterial homolog Swiss:Q9S408.


:

Pssm-ID: 460863  Cd Length: 292  Bit Score: 332.59  E-value: 2.39e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937903927  56 MDWILRGISQVVFVSNPISGILILAGLLVQNPWWALCGCVGTVVSTLTALLLSQDRSAIAAGLQGYNATLVGILMAVFSD 135
Cdd:pfam03253   1 IDAILRGIGQVMFQNNPLSGLLILAGLFFGSPWLGLLGLLGTLVSTLTALLLGQDRAEIRAGLYGYNGVLVGLALGVFLE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937903927 136 KGdyfWWLIFPVSAMSMTCPVFSSALSSLFSKWDLPVFTLPFNMALSLYLSATGHYNTFFPSKLFMPVSSVPNITWSElS 215
Cdd:pfam03253  81 PS---PLLLLLVVLGAALSTLVTAALARILSPWKLPVLTLPFVLVTWLLLLATGSFNPLLPSSLAAPALPLPNVTASD-D 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937903927 216 ALELLKSLPVGVGQIYGCDNPWTGAIFLCAILLSSPLMCLHAAIGSLLGVIAGLSLAAPFKDIYSGLWGFNSSLACIAIG 295
Cdd:pfam03253 157 LPDLLLGLFKGVGQVFFQDNVVTGLLILLALLISSRIAALLALLGSLLGLLAALLLGAPHSDIYSGLYGFNAVLTAIALG 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1937903927 296 GMFMALTWQTHLLALACALFTAYFGACMTHLMAAVHLPACTWSFC 340
Cdd:pfam03253 237 GVFLVPSWRSALLAVLGAVLTVFLQAALSTLLAPLGLPVLTWPFV 281
 
Name Accession Description Interval E-value
UT pfam03253
Urea transporter; Members of this family transport urea across membranes. The family includes ...
56-340 2.39e-113

Urea transporter; Members of this family transport urea across membranes. The family includes a bacterial homolog Swiss:Q9S408.


Pssm-ID: 460863  Cd Length: 292  Bit Score: 332.59  E-value: 2.39e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937903927  56 MDWILRGISQVVFVSNPISGILILAGLLVQNPWWALCGCVGTVVSTLTALLLSQDRSAIAAGLQGYNATLVGILMAVFSD 135
Cdd:pfam03253   1 IDAILRGIGQVMFQNNPLSGLLILAGLFFGSPWLGLLGLLGTLVSTLTALLLGQDRAEIRAGLYGYNGVLVGLALGVFLE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937903927 136 KGdyfWWLIFPVSAMSMTCPVFSSALSSLFSKWDLPVFTLPFNMALSLYLSATGHYNTFFPSKLFMPVSSVPNITWSElS 215
Cdd:pfam03253  81 PS---PLLLLLVVLGAALSTLVTAALARILSPWKLPVLTLPFVLVTWLLLLATGSFNPLLPSSLAAPALPLPNVTASD-D 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937903927 216 ALELLKSLPVGVGQIYGCDNPWTGAIFLCAILLSSPLMCLHAAIGSLLGVIAGLSLAAPFKDIYSGLWGFNSSLACIAIG 295
Cdd:pfam03253 157 LPDLLLGLFKGVGQVFFQDNVVTGLLILLALLISSRIAALLALLGSLLGLLAALLLGAPHSDIYSGLYGFNAVLTAIALG 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1937903927 296 GMFMALTWQTHLLALACALFTAYFGACMTHLMAAVHLPACTWSFC 340
Cdd:pfam03253 237 GVFLVPSWRSALLAVLGAVLTVFLQAALSTLLAPLGLPVLTWPFV 281
Utp COG4413
Urea transporter [Amino acid transport and metabolism];
52-340 1.97e-66

Urea transporter [Amino acid transport and metabolism];


Pssm-ID: 443533  Cd Length: 302  Bit Score: 212.81  E-value: 1.97e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937903927  52 VLQFMDWILRGISQVVFVSNPISGILILAGLLVQNPWWALCGCVGTVVSTLTALLLSQDRSAIAAGLQGYNATLVGILMA 131
Cdd:COG4413     3 LLDFIRALLRGIGQVFFQNNALTGLLILAAIALASPRLGLGALLGVLIATLTARLLGFDRAEIRAGLYGFNGALVGLALG 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937903927 132 VFSDKGDYFWWLIFPVSAMSMtcpVFSSALSSLFSKWDLPVFTLPFNMALSLYLSATGHYNTFFPSKLFMPVSSVPNITW 211
Cdd:COG4413    83 FFFGPSPASWVLLVLGAALSA---LVTAALSRLLIPWGLPALTLPFVLVTWLLLLAAYKFGGLPVSPLLPPALPAPASAT 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937903927 212 SELSALELLKSLPVGVGQIYGCDNPWTGAIFLCAILLSSPLMCLHAAIGSLLGVIAGLSLAAPFKDIYSGLWGFNSSLAC 291
Cdd:COG4413   160 NGLTLPDLVEALFKGVGQVFFQDSWVAGLLILAGLAIASRIAALLALIGSVLGLLVALLLGAPPASIALGLYGFNAVLTA 239
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1937903927 292 IAIGGMFMALTWQTHLLALACALFTAYFGACMTHLMAAVHLPACTWSFC 340
Cdd:COG4413   240 IALGGVFLKPSPRSFLYALLGAILTVFLQAALTVLFAPLGLPVLTAPFV 288
urea_trans_yut TIGR03441
urea transporter, Yersinia type; Members of this protein family are bacterial urea ...
54-339 1.07e-40

urea transporter, Yersinia type; Members of this protein family are bacterial urea transporters, found not only is species that contain urease, but adjacent to the urease operon. It was characterized in Yersinia pseudotuberculosis. Members are homologous to eukaryotic members of solute carrier family 14, a family that includes urea transporters, and to bacterial proteins in species with no detectable urea degradation system. [Transport and binding proteins, Other]


Pssm-ID: 163267  Cd Length: 292  Bit Score: 145.54  E-value: 1.07e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937903927  54 QFMDWILRGISQVVFVSNPISGILILAGLLVQNPWWALCGCVGTVVSTLTALLLSQDRSAIAAGLQGYNATLVGILMAVF 133
Cdd:TIGR03441   2 KLIDVLLRGISQVVFQNNPLTGLFFLIALFIGNWAVGIGALIGVLVATLTARLLNYDKKSIRSGLYGFNGVLVGIALPLF 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937903927 134 SDKGDYFWWLIFPVSAMSMtcpVFSSALSSLFSKWDLPVFTLPFNMALSLYLSATGHYNTFFPSKLFMPVSSVPNITwSE 213
Cdd:TIGR03441  82 LAPSPQLWAIIVIGSILST---VVMAAVSEILKPWKVPALTMPFVLTTWIFLLASYAFKGLHTDAPVLPHDIEPVAF-GG 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937903927 214 LSALELLKSLPVGVGQIYGCDNPWTGAIFLCAILLSSPLMCLHAAIGSLLGVIAGLSLAAPFKDIYSGLWGFNSSLACIA 293
Cdd:TIGR03441 158 PARENFFVAFFKGFSQVFLLDSAIAGVLILIGILIASRKAAIMALIGALISILAAILLGADLDSINQGLFGFNPVLTAIA 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1937903927 294 IGGMFMALTWQTHLLALACALFTAYFGACMTHLMAAVHLPACTWSF 339
Cdd:TIGR03441 238 LGVVFLRPSIRSAAYAVLGVVLTVFVQGALDTLLTPLGLPTLTFPF 283
 
Name Accession Description Interval E-value
UT pfam03253
Urea transporter; Members of this family transport urea across membranes. The family includes ...
56-340 2.39e-113

Urea transporter; Members of this family transport urea across membranes. The family includes a bacterial homolog Swiss:Q9S408.


Pssm-ID: 460863  Cd Length: 292  Bit Score: 332.59  E-value: 2.39e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937903927  56 MDWILRGISQVVFVSNPISGILILAGLLVQNPWWALCGCVGTVVSTLTALLLSQDRSAIAAGLQGYNATLVGILMAVFSD 135
Cdd:pfam03253   1 IDAILRGIGQVMFQNNPLSGLLILAGLFFGSPWLGLLGLLGTLVSTLTALLLGQDRAEIRAGLYGYNGVLVGLALGVFLE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937903927 136 KGdyfWWLIFPVSAMSMTCPVFSSALSSLFSKWDLPVFTLPFNMALSLYLSATGHYNTFFPSKLFMPVSSVPNITWSElS 215
Cdd:pfam03253  81 PS---PLLLLLVVLGAALSTLVTAALARILSPWKLPVLTLPFVLVTWLLLLATGSFNPLLPSSLAAPALPLPNVTASD-D 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937903927 216 ALELLKSLPVGVGQIYGCDNPWTGAIFLCAILLSSPLMCLHAAIGSLLGVIAGLSLAAPFKDIYSGLWGFNSSLACIAIG 295
Cdd:pfam03253 157 LPDLLLGLFKGVGQVFFQDNVVTGLLILLALLISSRIAALLALLGSLLGLLAALLLGAPHSDIYSGLYGFNAVLTAIALG 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1937903927 296 GMFMALTWQTHLLALACALFTAYFGACMTHLMAAVHLPACTWSFC 340
Cdd:pfam03253 237 GVFLVPSWRSALLAVLGAVLTVFLQAALSTLLAPLGLPVLTWPFV 281
Utp COG4413
Urea transporter [Amino acid transport and metabolism];
52-340 1.97e-66

Urea transporter [Amino acid transport and metabolism];


Pssm-ID: 443533  Cd Length: 302  Bit Score: 212.81  E-value: 1.97e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937903927  52 VLQFMDWILRGISQVVFVSNPISGILILAGLLVQNPWWALCGCVGTVVSTLTALLLSQDRSAIAAGLQGYNATLVGILMA 131
Cdd:COG4413     3 LLDFIRALLRGIGQVFFQNNALTGLLILAAIALASPRLGLGALLGVLIATLTARLLGFDRAEIRAGLYGFNGALVGLALG 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937903927 132 VFSDKGDYFWWLIFPVSAMSMtcpVFSSALSSLFSKWDLPVFTLPFNMALSLYLSATGHYNTFFPSKLFMPVSSVPNITW 211
Cdd:COG4413    83 FFFGPSPASWVLLVLGAALSA---LVTAALSRLLIPWGLPALTLPFVLVTWLLLLAAYKFGGLPVSPLLPPALPAPASAT 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937903927 212 SELSALELLKSLPVGVGQIYGCDNPWTGAIFLCAILLSSPLMCLHAAIGSLLGVIAGLSLAAPFKDIYSGLWGFNSSLAC 291
Cdd:COG4413   160 NGLTLPDLVEALFKGVGQVFFQDSWVAGLLILAGLAIASRIAALLALIGSVLGLLVALLLGAPPASIALGLYGFNAVLTA 239
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1937903927 292 IAIGGMFMALTWQTHLLALACALFTAYFGACMTHLMAAVHLPACTWSFC 340
Cdd:COG4413   240 IALGGVFLKPSPRSFLYALLGAILTVFLQAALTVLFAPLGLPVLTAPFV 288
urea_trans_yut TIGR03441
urea transporter, Yersinia type; Members of this protein family are bacterial urea ...
54-339 1.07e-40

urea transporter, Yersinia type; Members of this protein family are bacterial urea transporters, found not only is species that contain urease, but adjacent to the urease operon. It was characterized in Yersinia pseudotuberculosis. Members are homologous to eukaryotic members of solute carrier family 14, a family that includes urea transporters, and to bacterial proteins in species with no detectable urea degradation system. [Transport and binding proteins, Other]


Pssm-ID: 163267  Cd Length: 292  Bit Score: 145.54  E-value: 1.07e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937903927  54 QFMDWILRGISQVVFVSNPISGILILAGLLVQNPWWALCGCVGTVVSTLTALLLSQDRSAIAAGLQGYNATLVGILMAVF 133
Cdd:TIGR03441   2 KLIDVLLRGISQVVFQNNPLTGLFFLIALFIGNWAVGIGALIGVLVATLTARLLNYDKKSIRSGLYGFNGVLVGIALPLF 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937903927 134 SDKGDYFWWLIFPVSAMSMtcpVFSSALSSLFSKWDLPVFTLPFNMALSLYLSATGHYNTFFPSKLFMPVSSVPNITwSE 213
Cdd:TIGR03441  82 LAPSPQLWAIIVIGSILST---VVMAAVSEILKPWKVPALTMPFVLTTWIFLLASYAFKGLHTDAPVLPHDIEPVAF-GG 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937903927 214 LSALELLKSLPVGVGQIYGCDNPWTGAIFLCAILLSSPLMCLHAAIGSLLGVIAGLSLAAPFKDIYSGLWGFNSSLACIA 293
Cdd:TIGR03441 158 PARENFFVAFFKGFSQVFLLDSAIAGVLILIGILIASRKAAIMALIGALISILAAILLGADLDSINQGLFGFNPVLTAIA 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1937903927 294 IGGMFMALTWQTHLLALACALFTAYFGACMTHLMAAVHLPACTWSF 339
Cdd:TIGR03441 238 LGVVFLRPSIRSAAYAVLGVVLTVFVQGALDTLLTPLGLPTLTFPF 283
Utp COG4413
Urea transporter [Amino acid transport and metabolism];
50-187 8.82e-19

Urea transporter [Amino acid transport and metabolism];


Pssm-ID: 443533  Cd Length: 302  Bit Score: 85.69  E-value: 8.82e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937903927  50 PVVLQFMDWILRGISQVVFVSNPISGILILAGLLVQNPWWALCGCVGTVVSTLTALLLSQDRSAIAAGLQGYNATLVGIL 129
Cdd:COG4413   162 LTLPDLVEALFKGVGQVFFQDSWVAGLLILAGLAIASRIAALLALIGSVLGLLVALLLGAPPASIALGLYGFNAVLTAIA 241
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937903927 130 MAVFSDKGDY--FWWLIFPVsamsMTCPVFSSALSSLFSKWDLPVFTLPFNMALSLYLSA 187
Cdd:COG4413   242 LGGVFLKPSPrsFLYALLGA----ILTVFLQAALTVLFAPLGLPVLTAPFVLATWLFLLA 297
Utp COG4413
Urea transporter [Amino acid transport and metabolism];
215-340 4.95e-17

Urea transporter [Amino acid transport and metabolism];


Pssm-ID: 443533  Cd Length: 302  Bit Score: 80.68  E-value: 4.95e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937903927 215 SALELLKSLPVGVGQIYGCDNPWTGAIFLCAILLSSPLMCLHAAIGSLLGVIAGLSLAAPFKDIYSGLWGFNSSLACIAI 294
Cdd:COG4413     2 PLLDFIRALLRGIGQVFFQNNALTGLLILAAIALASPRLGLGALLGVLIATLTARLLGFDRAEIRAGLYGFNGALVGLAL 81
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1937903927 295 gGMFMALTWQTHLLALACALFTAYFGACMTHLMAAVHLPACTWSFC 340
Cdd:COG4413    82 -GFFFGPSPASWVLLVLGAALSALVTAALSRLLIPWGLPALTLPFV 126
urea_trans_yut TIGR03441
urea transporter, Yersinia type; Members of this protein family are bacterial urea ...
50-185 1.63e-09

urea transporter, Yersinia type; Members of this protein family are bacterial urea transporters, found not only is species that contain urease, but adjacent to the urease operon. It was characterized in Yersinia pseudotuberculosis. Members are homologous to eukaryotic members of solute carrier family 14, a family that includes urea transporters, and to bacterial proteins in species with no detectable urea degradation system. [Transport and binding proteins, Other]


Pssm-ID: 163267  Cd Length: 292  Bit Score: 58.48  E-value: 1.63e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937903927  50 PVVLQFMDWILRGISQVVFVSNPISGILILAGLLVQNPWWALCGCVGTVVSTLTALLLSQDRSAIAAGLQGYNATL---- 125
Cdd:TIGR03441 158 PARENFFVAFFKGFSQVFLLDSAIAGVLILIGILIASRKAAIMALIGALISILAAILLGADLDSINQGLFGFNPVLtaia 237
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937903927 126 VGILMAVFSDKGdyfwwLIFPVSAMSMTCpVFSSALSSLFSKWDLPVFTLPFNMALSLYL 185
Cdd:TIGR03441 238 LGVVFLRPSIRS-----AAYAVLGVVLTV-FVQGALDTLLTPLGLPTLTFPFVLVTWLFL 291
urea_trans_yut TIGR03441
urea transporter, Yersinia type; Members of this protein family are bacterial urea ...
218-344 3.51e-09

urea transporter, Yersinia type; Members of this protein family are bacterial urea transporters, found not only is species that contain urease, but adjacent to the urease operon. It was characterized in Yersinia pseudotuberculosis. Members are homologous to eukaryotic members of solute carrier family 14, a family that includes urea transporters, and to bacterial proteins in species with no detectable urea degradation system. [Transport and binding proteins, Other]


Pssm-ID: 163267  Cd Length: 292  Bit Score: 57.33  E-value: 3.51e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937903927 218 ELLKSLPVGVGQIYGCDNPWTGAIFLCAILLSSPLMCLHAAIGSLLGVIAGLSLAAPFKDIYSGLWGFNSSLACIAIGgM 297
Cdd:TIGR03441   2 KLIDVLLRGISQVVFQNNPLTGLFFLIALFIGNWAVGIGALIGVLVATLTARLLNYDKKSIRSGLYGFNGVLVGIALP-L 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1937903927 298 FMALTWQTHLLALACALFTAYFGACMTHLMAAVHLPACTWSFCLATL 344
Cdd:TIGR03441  81 FLAPSPQLWAIIVIGSILSTVVMAAVSEILKPWKVPALTMPFVLTTW 127
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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