NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|148806881|ref|NP_065899|]
View 

junctional cadherin 5-associated protein isoform 1 [Homo sapiens]

Protein Classification

JCAD domain-containing protein( domain architecture ID 12173170)

JCAD domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
JCAD pfam15351
Junctional protein associated with coronary artery disease; JCAD is a component of ...
 1-1348 0e+00

Junctional protein associated with coronary artery disease; JCAD is a component of VE-cadherin-based cell-cell junctions in endothelial cells. The cell-cell or adherens junction is an adhesion complex that plays a crucial role in the organization and function of epithelial and endothelial cellular sheets. These junctions join the actin cytoskeleton to the plasma membrane to form adhesive contacts between cells or between cells and extracellular matrix. The junctions also mediate both cell adhesion and cell-signalling. JCAD localizes close to the apical membrane in epithelial cells. This family is found in eukaryotes.


:

Pssm-ID: 434658  Cd Length: 1358  Bit Score: 2226.88  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148806881     1 MYSVEDLLISHGYKLSRDPPASREDNPKGRQAARTGTRAGQGLQNGHEDGPAALAHRKTSAGKGHVSDSESRRSTPRGHG 80
Cdd:pfam15351    1 MYSVEDLLISHGYKLSRDLPAPREDRYEGRQQARTRTRAGHGLLNGCEDGPAALAHSKKSLGKGHVSDSESRRRGPRGHG 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148806881    81 EPQSTSASRTSEAGFCNQPPSAWSSHPPTGNDQAYRRRGRQEARSQ-KPREHENLEARGMAQAHSLPVHVREGPWEVGGR 159
Cdd:pfam15351   81 EPQSTSASRASEAGFYNQPVLAWSSQPQTGKDHAYWRRRGQEVSGLlGPRDREDLEVRGMAQAHSLPVHVREGPWEVGGR 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148806881   160 SEHVMKKPVWEEELRMSGPAKWQNVSLESWNQPRKLGRQMSDGDGERLFQDLYPFIQGEHVLNSQNKGKSRSLPRVLSPE 239
Cdd:pfam15351  161 TEHVMKKAVWEEELRMSGPAKWQNVSLESWNQPRKLGRQMSDGDGEKLFQDLYPFIQGEHVLTSQNKGKSQSLPRVLSPE 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148806881   240 SLSCTEIPIPLNERHS---PKMPPYPPTCAPNLDSTRNSEKSGCSAPFPRPKFGRPLKPPSYSSHQQSRGGADSSDSQDS 316
Cdd:pfam15351  241 SLSCMEIPIPLNDGHLpgvPKMPPYPPNCAPNLESTRNPEKGGSSAPLPRPKFGRPLKPPSYESHQQSRGGVENSDYQDS 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148806881   317 QQMDAYV--------PRHELCLSDPGLEPPVYVPPPSYRSPPQNIPNPYLEDTVPINVCGGHSQQQSPTEKAGASGQPPS 388
Cdd:pfam15351  321 QQADLCVsyltrtsdPRQELCAPDPGLEPPVYVPPPSYRSPPQHIPNPYLEDAVPRHVSGGHSQQQHPTEKPGASCQLPS 400

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148806881   389 GPPGTGNEYGVSPRLPQGLPAHPRPVTAYDGFVQYIPFDDPRLRHFKLAQPQGFCEDIKLDDKSYNSSPVTAQEPAHGGM 468
Cdd:pfam15351  401 GSLGTGNEYGASPRSPRGLPPHPRPVTAYDGSVQYIPFDDPRIRHIKLAQPQGFCEETKLDDKSYSSGPVTAQEPARGEM 480

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148806881   469 QPDGAIWNPQSLIPPSGDERGLVLADSSPRWLWGQPPGDGENSGLPNQRDRCVARGQWPDVRGSQHGHTGRQVSSPYSQG 548
Cdd:pfam15351  481 QHDGAVLNPQSLTPPSGSERGPAFADPSPRWLWGQLPRDGENGGFPDQRDHCVVRGQWPDVRGSQHGHAEGQVSSPSPQG 560

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148806881   549 ESTCETQTKLKKFQTGTRTKKSSKKKMNETIFCLVSIPVKSESHLPDRDMDNNDLKPSADQKNGSDKSPALQEQSLLSMS 628
Cdd:pfam15351  561 ESTCETQTKLKKFETGIQTKKSSKKKMNETIFCLVSIPVKSESHLPDTDTNNNDLKQSADKKNGLDKSGALQEQSLLSMS 640

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148806881   629 STDLELQALTGSMGGRTEFQKQDLGEPEEDRQTNDLSFIHLTKHRELKHSGSWPGHRYRDQQTQTSFSEEPQSSQLLPGA 708
Cdd:pfam15351  641 STDLELQALTGSMAGRTELQKQDLGEPEEDKQTNDLRFIHPAKHRELKYSGSWPGHQYRDQQTQTSFTEESKSSQLLPAE 720

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148806881   709 KLGGPSRAALSPKCSDPAASEAQTHTAFPTGDHKQRPSARNLKGHRSLSPSSNSAFSRTSLSVDQAPTPKAGRSQPCVDV 788
Cdd:pfam15351  721 KPGGSSNAAPTPKCLDPTASEAQTHTALASSDQNQRPSAPSLKGQMSLSPSSNSAFSRTSSSINQAPVPKAGQSQPCVDV 800

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148806881   789 HGLGAHPGPKREVVKGEPTGPCNSKQLFGQFLLKPVSRRPWDLISQLESFNKELQeeEESSSSSSSSSSSSEESEAEPQQ 868
Cdd:pfam15351  801 RGRGASPVPRGEVVKGETTGPCNSKQLFGQFLLKPVSRRPWDLISQLESFNKELQ--EEEESSSSSSGSSSEDSEAEWQP 878

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148806881   869 ENRAHCRQEDVGFRGNSPEMRVEPQPRMWVPESPVCRSGRGESKSESWSEELQPGHPRAWPPSPGRFRVEEGGGAPFCSA 948
Cdd:pfam15351  879 EDCADSRPKSPGFREDSQEMRVEQQPRRLVPEDPVFRSGRVKSKSESWSEEPKPGHPCACPQSPGPSQVEDGRGEPFLSA 958

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148806881   949 DGSTSAEKRHLEVSNGMDELAGSPFPVTR-MSSRSSDAKPLPASYPAEPREPQESPKITSAFSSVKPSEAVPRKFDSGGE 1027
Cdd:pfam15351  959 DGSLITEKRKQEVGNRINELAVSPGPVKRiTSSRSSDTKPVPPSYPAELREPQESQKLPDALSSVQLSKAAPPRAGGGEE 1038

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148806881  1028 RGAGLPLSLSNKNRGLSAPDLRSVGLTPGQEQGASELEGSLGEASTIEIPPGESLQARAARILGIEVAVESLLPGIRRAG 1107
Cdd:pfam15351 1039 RGTAVPLSLASKSRGLSAPDLRSVGLTPGQEQSASKLDGSLGEASAIEIPPNESLQARAARILGIEVAVESLLPGARRTG 1118

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148806881  1108 QNQPAEPDASACTPESPQEELLSRPAPADVPRVSTDAFYGRRKCGWTKSPLFVGDRDSARRAPQAFEHSDVDGVVTSTDP 1187
Cdd:pfam15351 1119 QSQPPEPDGSACSPESPREESVSSSAPPDGPTVSTDAFYGRRKCGWTESPLFVGERDSARRAPQASEHSGVDGVVPSQAP 1198

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148806881  1188 VPEPEPSPLESKFFEQKDVETKPPFRSTLFHFVERTPSVAGSEKRLRSPSKVIESLQEKLASPPRRADPDRLMRMKEVSS 1267
Cdd:pfam15351 1199 SPEPQPSPLESKSFEQKDVETKPPFRSTLFHFIERTPSVAGSEKRLRSTSKVIESLQEKLASPPRRADPDRLMRMKEVSS 1278

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148806881  1268 VSRMRVLSFRNADSQEDAEELKAtTRGQAGLPGGLVSPGSGDRAQRLGHSLSVSKDSISREEKEHPAAQKEKSMDQDFWC 1347
Cdd:pfam15351 1279 VSRMRLLSSRSADSGEEAEELKA-ERGQAGQPGGPVSLNGGDRARKAGHSLSVSKGIISLEENGHPAAQREKNGDQDFWC 1357


                   .
gi 148806881  1348 P 1348
Cdd:pfam15351 1358 P 1358
 
Name Accession Description Interval E-value
JCAD pfam15351
Junctional protein associated with coronary artery disease; JCAD is a component of ...
 1-1348 0e+00

Junctional protein associated with coronary artery disease; JCAD is a component of VE-cadherin-based cell-cell junctions in endothelial cells. The cell-cell or adherens junction is an adhesion complex that plays a crucial role in the organization and function of epithelial and endothelial cellular sheets. These junctions join the actin cytoskeleton to the plasma membrane to form adhesive contacts between cells or between cells and extracellular matrix. The junctions also mediate both cell adhesion and cell-signalling. JCAD localizes close to the apical membrane in epithelial cells. This family is found in eukaryotes.


Pssm-ID: 434658  Cd Length: 1358  Bit Score: 2226.88  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148806881     1 MYSVEDLLISHGYKLSRDPPASREDNPKGRQAARTGTRAGQGLQNGHEDGPAALAHRKTSAGKGHVSDSESRRSTPRGHG 80
Cdd:pfam15351    1 MYSVEDLLISHGYKLSRDLPAPREDRYEGRQQARTRTRAGHGLLNGCEDGPAALAHSKKSLGKGHVSDSESRRRGPRGHG 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148806881    81 EPQSTSASRTSEAGFCNQPPSAWSSHPPTGNDQAYRRRGRQEARSQ-KPREHENLEARGMAQAHSLPVHVREGPWEVGGR 159
Cdd:pfam15351   81 EPQSTSASRASEAGFYNQPVLAWSSQPQTGKDHAYWRRRGQEVSGLlGPRDREDLEVRGMAQAHSLPVHVREGPWEVGGR 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148806881   160 SEHVMKKPVWEEELRMSGPAKWQNVSLESWNQPRKLGRQMSDGDGERLFQDLYPFIQGEHVLNSQNKGKSRSLPRVLSPE 239
Cdd:pfam15351  161 TEHVMKKAVWEEELRMSGPAKWQNVSLESWNQPRKLGRQMSDGDGEKLFQDLYPFIQGEHVLTSQNKGKSQSLPRVLSPE 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148806881   240 SLSCTEIPIPLNERHS---PKMPPYPPTCAPNLDSTRNSEKSGCSAPFPRPKFGRPLKPPSYSSHQQSRGGADSSDSQDS 316
Cdd:pfam15351  241 SLSCMEIPIPLNDGHLpgvPKMPPYPPNCAPNLESTRNPEKGGSSAPLPRPKFGRPLKPPSYESHQQSRGGVENSDYQDS 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148806881   317 QQMDAYV--------PRHELCLSDPGLEPPVYVPPPSYRSPPQNIPNPYLEDTVPINVCGGHSQQQSPTEKAGASGQPPS 388
Cdd:pfam15351  321 QQADLCVsyltrtsdPRQELCAPDPGLEPPVYVPPPSYRSPPQHIPNPYLEDAVPRHVSGGHSQQQHPTEKPGASCQLPS 400

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148806881   389 GPPGTGNEYGVSPRLPQGLPAHPRPVTAYDGFVQYIPFDDPRLRHFKLAQPQGFCEDIKLDDKSYNSSPVTAQEPAHGGM 468
Cdd:pfam15351  401 GSLGTGNEYGASPRSPRGLPPHPRPVTAYDGSVQYIPFDDPRIRHIKLAQPQGFCEETKLDDKSYSSGPVTAQEPARGEM 480

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148806881   469 QPDGAIWNPQSLIPPSGDERGLVLADSSPRWLWGQPPGDGENSGLPNQRDRCVARGQWPDVRGSQHGHTGRQVSSPYSQG 548
Cdd:pfam15351  481 QHDGAVLNPQSLTPPSGSERGPAFADPSPRWLWGQLPRDGENGGFPDQRDHCVVRGQWPDVRGSQHGHAEGQVSSPSPQG 560

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148806881   549 ESTCETQTKLKKFQTGTRTKKSSKKKMNETIFCLVSIPVKSESHLPDRDMDNNDLKPSADQKNGSDKSPALQEQSLLSMS 628
Cdd:pfam15351  561 ESTCETQTKLKKFETGIQTKKSSKKKMNETIFCLVSIPVKSESHLPDTDTNNNDLKQSADKKNGLDKSGALQEQSLLSMS 640

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148806881   629 STDLELQALTGSMGGRTEFQKQDLGEPEEDRQTNDLSFIHLTKHRELKHSGSWPGHRYRDQQTQTSFSEEPQSSQLLPGA 708
Cdd:pfam15351  641 STDLELQALTGSMAGRTELQKQDLGEPEEDKQTNDLRFIHPAKHRELKYSGSWPGHQYRDQQTQTSFTEESKSSQLLPAE 720

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148806881   709 KLGGPSRAALSPKCSDPAASEAQTHTAFPTGDHKQRPSARNLKGHRSLSPSSNSAFSRTSLSVDQAPTPKAGRSQPCVDV 788
Cdd:pfam15351  721 KPGGSSNAAPTPKCLDPTASEAQTHTALASSDQNQRPSAPSLKGQMSLSPSSNSAFSRTSSSINQAPVPKAGQSQPCVDV 800

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148806881   789 HGLGAHPGPKREVVKGEPTGPCNSKQLFGQFLLKPVSRRPWDLISQLESFNKELQeeEESSSSSSSSSSSSEESEAEPQQ 868
Cdd:pfam15351  801 RGRGASPVPRGEVVKGETTGPCNSKQLFGQFLLKPVSRRPWDLISQLESFNKELQ--EEEESSSSSSGSSSEDSEAEWQP 878

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148806881   869 ENRAHCRQEDVGFRGNSPEMRVEPQPRMWVPESPVCRSGRGESKSESWSEELQPGHPRAWPPSPGRFRVEEGGGAPFCSA 948
Cdd:pfam15351  879 EDCADSRPKSPGFREDSQEMRVEQQPRRLVPEDPVFRSGRVKSKSESWSEEPKPGHPCACPQSPGPSQVEDGRGEPFLSA 958

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148806881   949 DGSTSAEKRHLEVSNGMDELAGSPFPVTR-MSSRSSDAKPLPASYPAEPREPQESPKITSAFSSVKPSEAVPRKFDSGGE 1027
Cdd:pfam15351  959 DGSLITEKRKQEVGNRINELAVSPGPVKRiTSSRSSDTKPVPPSYPAELREPQESQKLPDALSSVQLSKAAPPRAGGGEE 1038

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148806881  1028 RGAGLPLSLSNKNRGLSAPDLRSVGLTPGQEQGASELEGSLGEASTIEIPPGESLQARAARILGIEVAVESLLPGIRRAG 1107
Cdd:pfam15351 1039 RGTAVPLSLASKSRGLSAPDLRSVGLTPGQEQSASKLDGSLGEASAIEIPPNESLQARAARILGIEVAVESLLPGARRTG 1118

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148806881  1108 QNQPAEPDASACTPESPQEELLSRPAPADVPRVSTDAFYGRRKCGWTKSPLFVGDRDSARRAPQAFEHSDVDGVVTSTDP 1187
Cdd:pfam15351 1119 QSQPPEPDGSACSPESPREESVSSSAPPDGPTVSTDAFYGRRKCGWTESPLFVGERDSARRAPQASEHSGVDGVVPSQAP 1198

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148806881  1188 VPEPEPSPLESKFFEQKDVETKPPFRSTLFHFVERTPSVAGSEKRLRSPSKVIESLQEKLASPPRRADPDRLMRMKEVSS 1267
Cdd:pfam15351 1199 SPEPQPSPLESKSFEQKDVETKPPFRSTLFHFIERTPSVAGSEKRLRSTSKVIESLQEKLASPPRRADPDRLMRMKEVSS 1278

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148806881  1268 VSRMRVLSFRNADSQEDAEELKAtTRGQAGLPGGLVSPGSGDRAQRLGHSLSVSKDSISREEKEHPAAQKEKSMDQDFWC 1347
Cdd:pfam15351 1279 VSRMRLLSSRSADSGEEAEELKA-ERGQAGQPGGPVSLNGGDRARKAGHSLSVSKGIISLEENGHPAAQREKNGDQDFWC 1357


                   .
gi 148806881  1348 P 1348
Cdd:pfam15351 1358 P 1358
 
Name Accession Description Interval E-value
JCAD pfam15351
Junctional protein associated with coronary artery disease; JCAD is a component of ...
 1-1348 0e+00

Junctional protein associated with coronary artery disease; JCAD is a component of VE-cadherin-based cell-cell junctions in endothelial cells. The cell-cell or adherens junction is an adhesion complex that plays a crucial role in the organization and function of epithelial and endothelial cellular sheets. These junctions join the actin cytoskeleton to the plasma membrane to form adhesive contacts between cells or between cells and extracellular matrix. The junctions also mediate both cell adhesion and cell-signalling. JCAD localizes close to the apical membrane in epithelial cells. This family is found in eukaryotes.


Pssm-ID: 434658  Cd Length: 1358  Bit Score: 2226.88  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148806881     1 MYSVEDLLISHGYKLSRDPPASREDNPKGRQAARTGTRAGQGLQNGHEDGPAALAHRKTSAGKGHVSDSESRRSTPRGHG 80
Cdd:pfam15351    1 MYSVEDLLISHGYKLSRDLPAPREDRYEGRQQARTRTRAGHGLLNGCEDGPAALAHSKKSLGKGHVSDSESRRRGPRGHG 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148806881    81 EPQSTSASRTSEAGFCNQPPSAWSSHPPTGNDQAYRRRGRQEARSQ-KPREHENLEARGMAQAHSLPVHVREGPWEVGGR 159
Cdd:pfam15351   81 EPQSTSASRASEAGFYNQPVLAWSSQPQTGKDHAYWRRRGQEVSGLlGPRDREDLEVRGMAQAHSLPVHVREGPWEVGGR 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148806881   160 SEHVMKKPVWEEELRMSGPAKWQNVSLESWNQPRKLGRQMSDGDGERLFQDLYPFIQGEHVLNSQNKGKSRSLPRVLSPE 239
Cdd:pfam15351  161 TEHVMKKAVWEEELRMSGPAKWQNVSLESWNQPRKLGRQMSDGDGEKLFQDLYPFIQGEHVLTSQNKGKSQSLPRVLSPE 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148806881   240 SLSCTEIPIPLNERHS---PKMPPYPPTCAPNLDSTRNSEKSGCSAPFPRPKFGRPLKPPSYSSHQQSRGGADSSDSQDS 316
Cdd:pfam15351  241 SLSCMEIPIPLNDGHLpgvPKMPPYPPNCAPNLESTRNPEKGGSSAPLPRPKFGRPLKPPSYESHQQSRGGVENSDYQDS 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148806881   317 QQMDAYV--------PRHELCLSDPGLEPPVYVPPPSYRSPPQNIPNPYLEDTVPINVCGGHSQQQSPTEKAGASGQPPS 388
Cdd:pfam15351  321 QQADLCVsyltrtsdPRQELCAPDPGLEPPVYVPPPSYRSPPQHIPNPYLEDAVPRHVSGGHSQQQHPTEKPGASCQLPS 400

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148806881   389 GPPGTGNEYGVSPRLPQGLPAHPRPVTAYDGFVQYIPFDDPRLRHFKLAQPQGFCEDIKLDDKSYNSSPVTAQEPAHGGM 468
Cdd:pfam15351  401 GSLGTGNEYGASPRSPRGLPPHPRPVTAYDGSVQYIPFDDPRIRHIKLAQPQGFCEETKLDDKSYSSGPVTAQEPARGEM 480

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148806881   469 QPDGAIWNPQSLIPPSGDERGLVLADSSPRWLWGQPPGDGENSGLPNQRDRCVARGQWPDVRGSQHGHTGRQVSSPYSQG 548
Cdd:pfam15351  481 QHDGAVLNPQSLTPPSGSERGPAFADPSPRWLWGQLPRDGENGGFPDQRDHCVVRGQWPDVRGSQHGHAEGQVSSPSPQG 560

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148806881   549 ESTCETQTKLKKFQTGTRTKKSSKKKMNETIFCLVSIPVKSESHLPDRDMDNNDLKPSADQKNGSDKSPALQEQSLLSMS 628
Cdd:pfam15351  561 ESTCETQTKLKKFETGIQTKKSSKKKMNETIFCLVSIPVKSESHLPDTDTNNNDLKQSADKKNGLDKSGALQEQSLLSMS 640

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148806881   629 STDLELQALTGSMGGRTEFQKQDLGEPEEDRQTNDLSFIHLTKHRELKHSGSWPGHRYRDQQTQTSFSEEPQSSQLLPGA 708
Cdd:pfam15351  641 STDLELQALTGSMAGRTELQKQDLGEPEEDKQTNDLRFIHPAKHRELKYSGSWPGHQYRDQQTQTSFTEESKSSQLLPAE 720

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148806881   709 KLGGPSRAALSPKCSDPAASEAQTHTAFPTGDHKQRPSARNLKGHRSLSPSSNSAFSRTSLSVDQAPTPKAGRSQPCVDV 788
Cdd:pfam15351  721 KPGGSSNAAPTPKCLDPTASEAQTHTALASSDQNQRPSAPSLKGQMSLSPSSNSAFSRTSSSINQAPVPKAGQSQPCVDV 800

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148806881   789 HGLGAHPGPKREVVKGEPTGPCNSKQLFGQFLLKPVSRRPWDLISQLESFNKELQeeEESSSSSSSSSSSSEESEAEPQQ 868
Cdd:pfam15351  801 RGRGASPVPRGEVVKGETTGPCNSKQLFGQFLLKPVSRRPWDLISQLESFNKELQ--EEEESSSSSSGSSSEDSEAEWQP 878

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148806881   869 ENRAHCRQEDVGFRGNSPEMRVEPQPRMWVPESPVCRSGRGESKSESWSEELQPGHPRAWPPSPGRFRVEEGGGAPFCSA 948
Cdd:pfam15351  879 EDCADSRPKSPGFREDSQEMRVEQQPRRLVPEDPVFRSGRVKSKSESWSEEPKPGHPCACPQSPGPSQVEDGRGEPFLSA 958

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148806881   949 DGSTSAEKRHLEVSNGMDELAGSPFPVTR-MSSRSSDAKPLPASYPAEPREPQESPKITSAFSSVKPSEAVPRKFDSGGE 1027
Cdd:pfam15351  959 DGSLITEKRKQEVGNRINELAVSPGPVKRiTSSRSSDTKPVPPSYPAELREPQESQKLPDALSSVQLSKAAPPRAGGGEE 1038

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148806881  1028 RGAGLPLSLSNKNRGLSAPDLRSVGLTPGQEQGASELEGSLGEASTIEIPPGESLQARAARILGIEVAVESLLPGIRRAG 1107
Cdd:pfam15351 1039 RGTAVPLSLASKSRGLSAPDLRSVGLTPGQEQSASKLDGSLGEASAIEIPPNESLQARAARILGIEVAVESLLPGARRTG 1118

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148806881  1108 QNQPAEPDASACTPESPQEELLSRPAPADVPRVSTDAFYGRRKCGWTKSPLFVGDRDSARRAPQAFEHSDVDGVVTSTDP 1187
Cdd:pfam15351 1119 QSQPPEPDGSACSPESPREESVSSSAPPDGPTVSTDAFYGRRKCGWTESPLFVGERDSARRAPQASEHSGVDGVVPSQAP 1198

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148806881  1188 VPEPEPSPLESKFFEQKDVETKPPFRSTLFHFVERTPSVAGSEKRLRSPSKVIESLQEKLASPPRRADPDRLMRMKEVSS 1267
Cdd:pfam15351 1199 SPEPQPSPLESKSFEQKDVETKPPFRSTLFHFIERTPSVAGSEKRLRSTSKVIESLQEKLASPPRRADPDRLMRMKEVSS 1278

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148806881  1268 VSRMRVLSFRNADSQEDAEELKAtTRGQAGLPGGLVSPGSGDRAQRLGHSLSVSKDSISREEKEHPAAQKEKSMDQDFWC 1347
Cdd:pfam15351 1279 VSRMRLLSSRSADSGEEAEELKA-ERGQAGQPGGPVSLNGGDRARKAGHSLSVSKGIISLEENGHPAAQREKNGDQDFWC 1357


                   .
gi 148806881  1348 P 1348
Cdd:pfam15351 1358 P 1358
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH