|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
38-422 |
5.75e-162 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 460.48 E-value: 5.75e-162
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 38 YCARSSMPICTVSMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGSITAVTPLLAHLSsah 117
Cdd:cd17380 12 YADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYSS--- 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 118 LAFMTFSRILMGLLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLW 197
Cdd:cd17380 89 LPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLW 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 198 VWYVYRYLlsekdlilalgvlaqsrpvsrhnrvpwrrlfrkPAVWAAVVSQLSAACSFFILLSWLPTFFEETF-PDAKGW 276
Cdd:cd17380 169 ALVWLIYL---------------------------------PPVWAIIVAHFCMNWGFYILLSWLPTYFHEVLvPLAKGW 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 277 IFNVVPWLVAIPASLFSGFLSDHLINQGYRAITVRKLMQGMGLGLSSVFALCLGHTSSFCESVVFASASIGLQTFNHSGI 356
Cdd:cd17380 216 VFNVVPWLVMFPSSNVAGWLADHLISRGWTVTSVRKLMQSIGFLGPALFLLLLSHTDSFSLALLCMSVALGLSAFSSSGV 295
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1519473565 357 SVNIQDLAPSCAGFLFGVANTAGALAGVVGVCLGGYLMETTGSWTCLFNLVAIISNLGLCTFLVFG 422
Cdd:cd17380 296 LVNHQDIAPNYAGIVFGISNTAGTIPGIVGVYLTGYILEATGSWSLVFVLAAVVNLVGAVVFLLFG 361
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
38-422 |
3.03e-121 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 358.08 E-value: 3.03e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 38 YCARSSMPICTVSMSQ----------------------DFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILL 95
Cdd:cd17318 12 YAMRVNLSVAIVAMVNstathdnnntstdkdtlpveapEFDWSEKTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGY 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 96 SASAWGSITAVTPLLAHLssaHLAFMTFSRILMGLLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGS 175
Cdd:cd17318 92 SILITALLTLLTPLAARG---GYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSG 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 176 LLLEWYGWQSIFYFSGGLTLLWVWYVYRYLlsekdlilalgvlaqsrpvsrhnrvpwrrlfrkPAVWAAVVSQLSAACSF 255
Cdd:cd17318 169 FLCESLGWPSIFYIFGGLGLLWCLLWFFLV---------------------------------LPVWAIVVAHFGHNWGF 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 256 FILLSWLPTFFEET--FPDAKGWIFNVVPWLVAIPASLFSGFLSDHLINQG-YRAITVRKLMQGMGLGLSSVFALCLGH- 331
Cdd:cd17318 216 YTLLTELPTYMSDVlhFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGiLSTTTVRKLFTSIGFLGPGVFLIALGYl 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 332 TSSFCESVVFASASIGLQTFNHSGISVNIQDLAPSCAGFLFGVANTAGALAGVVGVCLGGYLM---ETTGSWTCLFNLVA 408
Cdd:cd17318 296 GSNATLAVVFLTLSVGLSGACYSGFLVNHLDLAPNYAGTLMGITNTAATIAGIISPLIVGAIVkndQTIGQWRIVFFISA 375
|
410
....*....|....
gi 1519473565 409 IISNLGLCTFLVFG 422
Cdd:cd17318 376 AIYILGAIFYLIFG 389
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
53-422 |
1.44e-42 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 154.55 E-value: 1.44e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 53 QDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGSITAVTPLLAHLSSAHLAFMtfsRILMGLLQ 132
Cdd:cd17381 58 KKYDWDAETQGWILGSFFYGYIITQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAGYLIAV---RALEGLGE 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 133 GVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLW--VWYVyryllsekd 210
Cdd:cd17381 135 GVTFPAMHAMWASWAPPLERSRLLTISYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWffLWIW--------- 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 211 LILALgvlaqsrpvsrhnrvpwrrlfrkpavWAAVVSQLSAACSFFILLSWLPTFFEET--FPDAKGWIFNVVPWLVAIP 288
Cdd:cd17381 206 LVMPL--------------------------WAIVVAHFSYNWTFYTLLTLLPTYMKEIlrFDIQENGFLSALPYLGCWL 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 289 ASLFSGFLSDHLI-NQGYRAITVRKLMQGMGLGLSSVFALCLGHTS-SFCESVVFASASIGLQTFNHSGISVNIQDLAPS 366
Cdd:cd17381 260 FMILSGQIADNLReKQNFSTVCVRKIFTLIGMIGPAVFLLAAGFTGcNYSLAVAFLTISSTLGGFSASGFNINHLDIAPS 339
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1519473565 367 CAGFLFGVANTAGALAGVVGVCLGGYLME--TTGSWTCLFNLVAIISNLGLCTFLVFG 422
Cdd:cd17381 340 YAGILLGITNTFATIPGMVGPVIAKSLTHnnTVEEWQTVFYISAAINVFGAIFFTIFG 397
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
41-420 |
3.67e-42 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 152.34 E-value: 3.67e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 41 RSSMPICTVSMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGSITAVTPLLAhlSSAHLAF 120
Cdd:cd17319 19 RVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFAT--SLTSLYV 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 121 MtfsRILMGLLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLWVWY 200
Cdd:cd17319 97 L---RFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 201 VYRYLlsekdlilalgvlaqsrpvsrhnrvpwrrlfrkPAVWAAVVSQLSAACSFFILLSWLPTFFEET--FPDAKGWIF 278
Cdd:cd17319 174 WWFYL---------------------------------RQVWGLALGYFGINYALYGLLTWLPTYLKQArgFSLKQVGLL 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 279 NVVPWLVAIPASLFSGFLSDHLINQgyraitVRKLMQGMGLGLSSVFALCLGHTSSFCESVVFASASIGLQTFNHSGISV 358
Cdd:cd17319 221 AAIPFLAGAIGMILGGRLSDRLLRG------ARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWS 294
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1519473565 359 NIQDLAP-SCAGFLFGVANTAGALAGVVGVCLGGYLMETTGSWTCLFNLVAIISNLGLCTFLV 420
Cdd:cd17319 295 LPADLLPgEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLL 357
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
55-422 |
3.30e-40 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 147.49 E-value: 3.30e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 55 FGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGSITAVTPLLAHLssaHLAFMTFSRILMGLLQGV 134
Cdd:cd17382 44 FNWTPETVGLIESSFFWGYLVTQIPGGFIAAKFAANRVFGLAIFVTSTLNMLIPIAARV---HYGCVIFVRILQGLVEGV 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 135 YFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLlwVWYVYRYLLSEkdlila 214
Cdd:cd17382 121 TYPACHGIWRKWAPPLERSRLATTAFCGSYAGAVVGMPLSGILVQYVGWSSPFYVYGVFGI--IWYMFWMLVSM------ 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 215 lgvlaqsrpvsrhnrvpwrrlfrkpAVWAAVVSQLSAACSFFILLSWLPTFFEETF--PDAKGWIFNVVPWLVAIPASLF 292
Cdd:cd17382 193 -------------------------PVYAIIVANFCRSWTFYLLLISQPAYFKEVFgfDISKVGILSALPHLVMTIIVPI 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 293 SGFLSDHLINQGYRAIT-VRKLMQGMGLGLSSVFALCLGHTSSFCESVVFASASIGLQTFNHSGISVNIQDLAPSCAGFL 371
Cdd:cd17382 248 GGQLADYLRSRGILSTTaVRKIFNCGGFGMEATFLLVVAFSHSPTVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASIL 327
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1519473565 372 FGVANTAGALAGVVGVCLGGYLM--ETTGSWTCLFNLVAIISNLGLCTFLVFG 422
Cdd:cd17382 328 MGISNGIGTLSGMVCPVIVGALTkhKTREEWQYVFLIASLVHFFGVIFYAIFA 380
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
41-409 |
1.48e-38 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 142.70 E-value: 1.48e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 41 RSSMPICTVSMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGSITAVTPLlahlsSAHLAF 120
Cdd:COG2271 26 RSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGF-----ATSFWQ 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 121 MTFSRILMGLLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLWVWY 200
Cdd:COG2271 101 LLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALL 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 201 vyryllsekdlilalgvlaqsrpvsrhnrvpwrrlfrkpAVWAAVVSQLSAACSFFILLSWLPTFFEET--FPDAKGWIF 278
Cdd:COG2271 181 ---------------------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVrgLSLAQAGLL 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 279 NVVPWLVAIPASLFSGFLSDHLINQGYRAITVrklmqgmGLGLSSVFALCLGHTSSFCESVVFASASIGLQTFNHSGISV 358
Cdd:COG2271 222 LSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAI-------GLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWA 294
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1519473565 359 NIQDLAP-SCAGFLFGVANTAGALAGVVGVCLGGYLMETTGSWTCLFNLVAI 409
Cdd:COG2271 295 LAAELFPkKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAAL 346
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
44-386 |
7.21e-33 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 126.76 E-value: 7.21e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 44 MPICTVSMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWgsitAVTPLLAHLSSAHLAFMtF 123
Cdd:pfam07690 16 GPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLF----ALGLLLLLFASSLWLLL-V 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 124 SRILMGLLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLWVWYVYR 203
Cdd:pfam07690 91 LRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 204 YLLSEKDlilalGVLAQSRPVSRHNRVPWRRLFRKPAVWAAVVSqLSAACSFFILLSWLPTFFEET-FPDAKGWIFNVVP 282
Cdd:pfam07690 171 PRPPPES-----KRPKPAEEARLSLIVAWKALLRDPVLWLLLAL-LLFGFAFFGLLTYLPLYQEVLgLSALLAGLLLGLG 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 283 WLVAIPASLFSGFLSDHLINQgyraitvRKLMQGMGLGLSSVFALCLGHTSSFCESVVFASASIGL-QTFNHSGISVNIQ 361
Cdd:pfam07690 245 GLLGAIGRLLLGRLSDRLGRR-------RRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFgFGLVFPALNALVS 317
|
330 340
....*....|....*....|....*.
gi 1519473565 362 DLAP-SCAGFLFGVANTAGALAGVVG 386
Cdd:pfam07690 318 DLAPkEERGTASGLYNTAGSLGGALG 343
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
55-435 |
1.77e-30 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 122.54 E-value: 1.77e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 55 FGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGSITAVTPLLAhlsSAHLAFMTFSRILMGLLQGV 134
Cdd:TIGR00894 71 FKWSGALQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAA---GGGIALVVFCRVIQGLAQGS 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 135 YFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLE-WYGWQSIFYFSG--GLTLLWVWYVYRY------- 204
Cdd:TIGR00894 148 VSPATHKIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCEsWGGWPMIFYVFGivGCAWSLLWFVFPAddpsihp 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 205 --LLSEKDLILAlgVLAQSRPVSRHNrVPWRRLFRKPAVWAAVVSQLSAACSFFILLSWLPTFFEET--FPDAKGWIFNV 280
Cdd:TIGR00894 228 ciSKFEKKYINS--SLQGQKGSTRQS-LPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVlrVSGKENGLLSS 304
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 281 VPWLVAIPASLFSGFLSDHLINQGYRAIT-VRKLMQGMGLGLSSVFALCLGHTSS-FCESVVFASASIGLQTFNHSGISV 358
Cdd:TIGR00894 305 LPYLFAWLCSIFAGYLADFLKSSKTLSLTaARKIFNGIGGLGPGIFAYALPYLSAaFYLTIIILTLANAVSSGPLAGVLI 384
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1519473565 359 NIQDLAPSCAGFLFGVANTAGALAGVVGVCLGGYLMET--TGSWTCLFNLVAIISNLGLCTFLVFGQAQRVDLSSTHED 435
Cdd:TIGR00894 385 NSLDLAPRFLGFIKGITGLPGFIGGLIASTLAGNILSQdsKNVWLIVFLIMAFVNILCVIFYLIFGSAERQDWAKEEKD 463
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
51-383 |
6.21e-27 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 110.45 E-value: 6.21e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 51 MSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGSITAVTPLlahlsSAHLAFMTFSRILMGL 130
Cdd:COG2814 36 IAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCAL-----APSLWLLLAARFLQGL 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 131 LQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLWvwyvyryllsekd 210
Cdd:COG2814 111 GAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLA------------- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 211 LILALGVLAQSRPVSRHN-RVPWRRLFRKPAVWAAVVSQLSAACSFFILLSWLPTFFEETF---PDAKGWIFnVVPWLVA 286
Cdd:COG2814 178 LLLLLRLLPESRPAARARlRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLglsASAAGLLL-ALFGLGG 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 287 IPASLFSGFLSDHLinqgyraitVRKLMQGMGLGLSSVFALCLGHTSSFCESVVFASASIGLQTFNHSGISVNIQDLAP- 365
Cdd:COG2814 257 VLGALLAGRLADRF---------GRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPp 327
|
330
....*....|....*...
gi 1519473565 366 SCAGFLFGVANTAGALAG 383
Cdd:COG2814 328 EARGRASGLYNSAFFLGG 345
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
38-426 |
3.00e-26 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 109.20 E-value: 3.00e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 38 YCARSSMPICTVSMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGsitavTPLLAHLSSAH 117
Cdd:COG2223 18 FGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLG-----IGLLLLALAVS 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 118 LAFMTFSRILMGLLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLW 197
Cdd:COG2223 93 YWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVV 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 198 VWYVYRYLLSEKdlilalgvlAQSRPVSRHNRVPWRRLFRKPAVWAAVVSQLSAACSFFILLSWLPTFFEETFPD--AKG 275
Cdd:COG2223 173 AVLAWLFLRDPP---------AGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLsaATA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 276 WIFNVVPWLVAIPASLFSGFLSDHlinqgyraITVRKLMQGMGLGLSSVFALCLGHTSSFcesVVFASASIGLQTFNHSG 355
Cdd:COG2223 244 GLLAALFALLGALGRPLGGWLSDR--------IGGRRVLLIVFALMALGLLLLALALGSL---WLFLVLFLLLGLALGGG 312
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1519473565 356 ISVNIQDLA----PSCAGFLFGVANTAGALAGVVGVCLGGYLMETTGSWTCLFNLVAIISNLGLCTFLVFGQAQR 426
Cdd:COG2223 313 NGAVFALVPdifpTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLYRRPR 387
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
53-420 |
6.44e-26 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 108.05 E-value: 6.44e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 53 QDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWgsitAVTPLLAHLSSaHLAFMTFSRILMGLLQ 132
Cdd:cd17325 24 ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLL----AVSTLLFAFAT-SYWQLLLARFLQGLAS 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 133 GVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLwvwyvyryllsekDLI 212
Cdd:cd17325 99 AAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALL-------------ALV 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 213 LALGVLAQSRPVSRHNRV-------PWRRLFRKPAVWAAVVSQLSAACSFFILLSWLPTFFEETF---PDAKGWIFNVVP 282
Cdd:cd17325 166 LALLLLPEPRPPPNKRAVsaarlrsGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGglsPAQIGLLFGAQG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 283 wLVAIPASLFSGFLSDHLinqgyraitVRKLMQGMGLGLSSVFALCLGHTSSFCESVVFASASIGLQTFNHSGISVNIQD 362
Cdd:cd17325 246 -LASALSQPPAGKLSDRI---------GRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLAD 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 363 LAPSCA-GFLFGVANTAGALAGVVGVCLGGYLMETTG-SWTCLFNLVAIISNLGLCTFLV 420
Cdd:cd17325 316 IVPPEGrGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGfATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
51-404 |
5.82e-22 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 96.85 E-value: 5.82e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 51 MSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGSITAVTPLlahlsSAHLAFMTFSRILMGL 130
Cdd:cd17324 25 IARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAAL-----APSFALLLLARALAGL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 131 LQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLWVWYVYRYLLSekd 210
Cdd:cd17324 100 AHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPS--- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 211 lilalgvLAQSRPVSRHNRVPWRRLFRKPAVWAAVVSQLSAACSFFILLSWLPTFFEETF---PDAKGWIFNVVpWLVAI 287
Cdd:cd17324 177 -------LPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPgfsSSAIIGLLLLF-GVAGV 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 288 PASLFSGFLSDHlinqgyraITVRKLMQGMGLGLSSVFALCLGHTSSFCESVVFASASIGLQtFNHSGISVNIQDLAPSC 367
Cdd:cd17324 249 VGSPLAGRLADR--------GGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFF-AAHSALQTRVLRLAPEA 319
|
330 340 350
....*....|....*....|....*....|....*..
gi 1519473565 368 AGFLFGVANTAGALAGVVGVCLGGYLMETTGSWTCLF 404
Cdd:cd17324 320 RGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGW 356
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
38-419 |
3.87e-21 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 94.42 E-value: 3.87e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 38 YCARSSMPICTVSMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGsitAVTPLLAhlSSAH 117
Cdd:cd06174 9 GLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFA---LGALLFA--FAPS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 118 LAFMTFSRILMGLLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEW--YGWQSIFYFSGGLTL 195
Cdd:cd06174 84 FWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAALAL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 196 LWVWYVYRYLLSEKDLILAlgvlAQSRPVSRHNRVPWRRLFRKPAVWAAVVSQLSAACSFFILLSWLPTFFEET--FPDA 273
Cdd:cd06174 164 LAAILLLLVVPDPPESARA----KNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLggLSVA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 274 KGWIFNVVPWLVAIPASLFSGFLSDHLINqgyraitvRKLMQGMGLGLSSVFALCLGHTSSFCESVVFAS-ASIGLQTFN 352
Cdd:cd06174 240 VAGLLLSLFGLAGALGSLLLGLLSDRLIG--------RKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLlLGFGLGGLL 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1519473565 353 HSGISVNIQDLAPSCAGFLFGVANTAGALAGVVGVCLGGYLMETTGSWTCLFNLVAIISNLGLCTFL 419
Cdd:cd06174 312 PLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
50-296 |
1.59e-15 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 76.77 E-value: 1.59e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 50 SMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGSITAVTPLlahlsSAHLAFMTFSRILMG 129
Cdd:COG0477 39 SIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGL-----APSPELLIAARALQG 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 130 LLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLWVWYVYRYLLSEK 209
Cdd:COG0477 114 IGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLRLPESRG 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 210 DLILALGVLAQSRPVSRHNRVPWRRLFRKPAVWAAVVSQLSAACSFFILLSWLPTFFEETFPDAKGWIFNVVPWLVAIPA 289
Cdd:COG0477 194 LLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLA 273
|
....*..
gi 1519473565 290 SLFSGFL 296
Cdd:COG0477 274 LLLALLL 280
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
51-425 |
4.04e-15 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 76.45 E-value: 4.04e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 51 MSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAwgsITAVTPLLAHLSSAHLAFmtFSRILMGL 130
Cdd:COG2807 44 IRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLL---LAAGLLLRSLAPSVALLL--AGTALIGA 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 131 LQGVYFPALTSLLSQKVRESeRAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLwvwyvyryllsekd 210
Cdd:COG2807 119 GIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALL-------------- 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 211 LILALGVLAQSRPVSRHN---RVPWRRLFRKPAVWAAVVSQLSAACSFFILLSWLPTFFEET--FPDAKGWIFNVVPwLV 285
Cdd:COG2807 184 ALLLWLPLLRRRPAAAAAapaAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAglSAATAGLLLSLFQ-LA 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 286 AIPASLFSGFLSDHLINQGYRAITVrklmqgMGLGLSSVFALCLGHTSSFCESVVFASASIGLqTFnhSGISVNIQDLAP 365
Cdd:COG2807 263 GIPGSLLVPLLADRLGDRRPLLLLL------GLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGG-LF--PLALTLIGLRAR 333
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1519473565 366 SC--AGFLFGVANTAGALAGVVGVCLGGYLMETTGSWTCLFNLVAIISNLGLCTFLVFGQAQ 425
Cdd:COG2807 334 TPaeAAALSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGLLAGRPY 395
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
38-420 |
8.09e-15 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 75.39 E-value: 8.09e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 38 YCARSSMPICTVSMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGSITAVTPLlahlsSAH 117
Cdd:cd17312 16 YVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGF-----STS 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 118 LAFMTFSRILMGLLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLW 197
Cdd:cd17312 91 LWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVV 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 198 VWYVYRYLLSekdlilalgvlaqsrpvsrhnrvpwrrlfRKPAVWaavvsQLSAACSF-----FILLSWLPTFFEETFPD 272
Cdd:cd17312 171 AIILFFFLRD-----------------------------SPPYVW-----VLSLAYAFvyivrYACLDWGPLYLYEVKGY 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 273 AK---GWIFNVVPwLVAIPASLFSGFLSDHLInQGYRAITVRKLMQGMGLGLSSVFALCLGHTSSFCESVVFASASIGLQ 349
Cdd:cd17312 217 SLidaGWFSSLYE-VGGIAGTILAGLLSDKLF-GGRRAPIAVIYMLLMTLSLALFWFFPHNKLLSIVLLFLIGFFVGGPI 294
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1519473565 350 TFNHSGISvniQDLAPSCA-GFLFGVANTAGALAGVVGVCLGGYLMETTGSWTclFNLVAIISNLGLCTFLV 420
Cdd:cd17312 295 NLIGGAAA---QDIGRKEAaGTATGFVGLFGYLGASLAGLPLGYIIDHYGWST--VFYFLISAALLSVLLLL 361
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
50-394 |
1.83e-14 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 74.70 E-value: 1.83e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 50 SMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGSITavtpLLAHLSSAHLAFMTFsRILMG 129
Cdd:TIGR00895 42 AISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFT----LLCALATNVTQLLIL-RFLAG 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 130 LLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLWVWYVYRYL-LSE 208
Cdd:TIGR00895 117 LGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLpESI 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 209 KDLIL--------------------ALGVLAQSRPVSRHNRVPWRRLFRK------PAVWAAVVSQLSaacSFFILLSWL 262
Cdd:TIGR00895 197 DFLVSkrpetvrrivnaiapqmqaeAQSALPEQKSTQGTKRSVFKALFQGktaritVLLWLLYFMLLV---GVYFLTNWL 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 263 PTFFEET-FPDAKGWIFNVVPWLVAIPASLFSGFLSDHLinqGYRAITVrklmqgmGLGLSSVFALCLGhtSSFCESVVF 341
Cdd:TIGR00895 274 PKLMVELgFSLSLAATGGALFNFGGVIGSIIFGWLADRL---GPRVTAL-------LLLLGAVFAVLVG--STLFSPTLL 341
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1519473565 342 ASASIGLQTFNHSGISVNIQDLA----PSCAGFLFGVANTAGALAGVVGVCLGGYLM 394
Cdd:TIGR00895 342 LLLGAIAGFFVNGGQSGLYALMAlfypTAIRATGVGWAIGIGRLGAIIGPILAGYLL 398
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
49-419 |
9.80e-14 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 72.27 E-value: 9.80e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 49 VSMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIgGEKVILLSASAwgsITAVTPLLAHLSSAHLAFMTFsRILM 128
Cdd:cd17475 20 PFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRF-GERRVLAVGLL---LMGAAALLMALVGSYPVLLVL-LFLV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 129 GLLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLWVWYVYRYLLSE 208
Cdd:cd17475 95 GAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREP 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 209 KDLILAlgvlaqsRPVSRHNRVPWRRLFRKPAVWAAVVSQLSAACSFFILLSWLPTFFEETF---PDAKGWIFNVVPWLv 285
Cdd:cd17475 175 PAASAA-------TESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLglsVVAAGALLAVAQLG- 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 286 AIPASLFSGFLSDHLINQGYRAITVrkLMQGMGLGLSSVFALCLGHTSSFceSVVFASASIGLQTFNHSGISVN-IQDLA 364
Cdd:cd17475 247 GALGRIGLGRVSDRVFGGRRRPVLV--ITAAIAAAALLVLSLLSPGTPLW--LLVLLLILLGLFAIGWNGLYLTlVAESA 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1519473565 365 P-SCAGFLFGVANTAGALAGVVGVCLGGYLMETTGSWTCLFNLVAIISNLGLCTFL 419
Cdd:cd17475 323 GpEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLLL 378
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
38-325 |
1.02e-12 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 69.33 E-value: 1.02e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 38 YCARSSMPICTVSMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGsitAVTPLLAhlSSAH 117
Cdd:TIGR00881 8 YLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCA---IVNLFFG--FSTS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 118 LAFMTFSRILMGLLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQF-GTLLTGAVGSLLLEWYGWQSIFYFSGGLTLL 196
Cdd:TIGR00881 83 LWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVgGGLLPPLVLFGIAELYSWHWVFIVPGIIAII 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 197 WVWYVYRyLLSEKDLILALGVLAQSR--------PVSRHNRVPWRRLFRK----PAVWAAVVSQLSAACSFFILLSWLPT 264
Cdd:TIGR00881 163 VSLICFL-LLRDSPQSCGLPPAEEMPneepdgdaEKKEEELTKKQIFLQYvllnKVLWYISLGYVFVYVVRTGILDWSPL 241
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1519473565 265 FFEET--FPDAKGWIFNVVPWLVAIPASLFSGFLSDHLINqGYRAITVRKLMQGMGLGLSSVF 325
Cdd:TIGR00881 242 YLTQEkgFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFN-GRRGPLAVFFMALIIVSLLVYW 303
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
40-413 |
1.25e-12 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 68.84 E-value: 1.25e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 40 ARSSMPICTVSMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGSITAVTPLLAHLSSAHLA 119
Cdd:cd17355 18 IRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 120 FMtfsrILMGLLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLWVW 199
Cdd:cd17355 98 WG----LLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLV 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 200 YVYRYLLSEKDLIlalGVLAQSRPVSRHNRVPWRRLFRKPAVWAAVVSQLSAACSFFILLSWLPTFFEETF--PDAKGWI 277
Cdd:cd17355 174 PVLLLLRRRPADL---ALRAYDDASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADRGisPAAAAVA 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 278 FNVVpWLVAIPASLFSGFLSDhlinqgyRAITVRKLMQGMGLGLSSVFALCLGHTSSFceSVVFASASIGLQTFNHSGIS 357
Cdd:cd17355 251 LALI-GLFNIVGRLLSGWLGD-------RYSPRRLLAASYALRALGLALLLLLPFPPL--ALLLFAALFGLGWGATVPLT 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1519473565 358 VNI--QDLAPSCAGFLFGVANTAGALAGVVGVCLGGYLMETTGSWT------CLFNLVAIISNL 413
Cdd:cd17355 321 AALaaRYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTaawalaVALGLIAALLVL 384
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
51-298 |
2.15e-12 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 68.43 E-value: 2.15e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 51 MSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGSITAVTPLLAHLSSahlaFMTFsRILMGL 130
Cdd:cd17327 32 MKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFGG----LIAL-RFFLGL 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 131 LQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLE------WYGWQSIFYFSGGLTLLWVWYVYRY 204
Cdd:cd17327 107 FESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKilgvggLAGWRWLFIIEGLITIIIGLVIFFW 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 205 L---------LSEKDLILALGVLAQSRPVSRHNRVPW---RRLFRKPAVWAAVVSQLSAACSFFILLSWLPTFFEETFPD 272
Cdd:cd17327 187 LpdnpskawfLTEEEKELAVERLRANQTGKGDQKFKWkqiKEAFKDPRTWLLFLFFFCSQITNNGISNFLPLILKSLGFY 266
|
250 260
....*....|....*....|....*..
gi 1519473565 273 -AKGWIFNVVPWLVAIPASLFSGFLSD 298
Cdd:cd17327 267 sLQTNLLSVPIGALGAVSLLIAALLSD 293
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
51-196 |
4.12e-12 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 67.22 E-value: 4.12e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 51 MSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGSITAVTPLlahlsSAHLAFMTFSRILMGL 130
Cdd:cd17325 226 AAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPL-----ATSFWLLLLLLALLGL 300
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1519473565 131 LQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLL 196
Cdd:cd17325 301 GLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLL 366
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
43-346 |
7.11e-12 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 66.52 E-value: 7.11e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 43 SMPICTVSMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGSITAVTPLLAHLSSAHLAfmt 122
Cdd:PRK11551 33 SAGVAAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVA--- 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 123 fsRILMGLLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLWVWYVY 202
Cdd:PRK11551 110 --RLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYVGGVGPLLLVPLLM 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 203 RYLLSEKDLILALGVLAQSRPVsrhnrvpWRRLF---RKPAVWAAVVSQLSAACSFFILLSWLPTFFEE---TFPDAkGW 276
Cdd:PRK11551 188 RWLPESRAFAQAAGAGKQRAPV-------LRALFgegRATATLLLWISYFFTLIVLYFLLNWLPSLLVGqglSRSQA-GL 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 277 I---FNVvpwlVAIPASLFSGFLSDHLinqgyRAITVRKLMQG------MGLGLSSVF------ALCLGHTSSFCESVVF 341
Cdd:PRK11551 260 VqiaFNI----GGALGSLLIGALMDRL-----RPRRVVLLIYAgilaslAALAAAPSFagmllaGFAAGLFVVGGQSVLY 330
|
....*
gi 1519473565 342 ASASI 346
Cdd:PRK11551 331 ALAPL 335
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
50-420 |
1.64e-11 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 65.30 E-value: 1.64e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 50 SMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGSITAVTpllAHLSSAHLafMTFSRILMG 129
Cdd:cd17365 24 ALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLT---AFAQSVLQ--LALLRFLTG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 130 LLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLWvwyvyryllsek 209
Cdd:cd17365 99 LGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLIL------------ 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 210 dLILALGVLaqsrpvsrhnrvpwrrlfrkpAVWAA-VVSQLsaacSFFILLSWLPTFFEET-FPDAKGWIFNVVPWLVAI 287
Cdd:cd17365 167 -LPLLRGTL---------------------LLWVTfFMGLL----LVYLLNSWLPKLMVEAgYSLSQALTITLLLNIGGV 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 288 PASLFSGFLSDHlinqgYRAITVrkLMQGMGLGLSSVFALCLGHTSSFCESVVFASASIGLqtfnhSGISVNIQDLAP-- 365
Cdd:cd17365 221 IGSLLLGWLADR-----FGPKRV--LALFFALGAVSLALLGVSPASLVLLYVLVFLAGACV-----NGAQVGLYALAArf 288
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1519473565 366 ---SCAGFLFGVANTAGALAGVVGVCLGGYLMETTGSWTCLFNLVAIISNLG-LCTFLV 420
Cdd:cd17365 289 yptEVRATGVGWALGVGRLGAILGPLLGGLLLAAGLGPESVFLALAIPAALGaLAVLLL 347
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
51-419 |
4.13e-11 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 64.13 E-value: 4.13e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 51 MSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSAsawgSITAVTPLLAHLSSaHLAFMTFSRILMGL 130
Cdd:cd17320 25 IARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGL----LLFILASLLCALAS-SIEQLLIARFLQGL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 131 lqGVYFPALT--SLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYF---SGGLTLLWVWYVYRYL 205
Cdd:cd17320 100 --GAAAGSVVarAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFlalLGLLLLLLVLLFLPET 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 206 LSEKDLILALGVLAQSrpvsrhnrvpWRRLFRKPAVWAAVVSQLSAACSFFILLSWLPTFFEETF---PDAKGWIFnvvp 282
Cdd:cd17320 178 LPEEKRKPLLSSLLRA----------YKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLglsPAQFGLLF---- 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 283 wLVAIPASLFSGFLSDHLINQgyraITVRKLMqGMGLGLSSVFALCL-GHTSSFCESVVFASASIGLQTFNHSGISVNIQ 361
Cdd:cd17320 244 -ALNAIALILGSLLNGRLVRR----FGPRRLL-RLGLLLLLAAALVLlLAALLGGLSLWPLVAPLFLIFFGFGLIFPNAT 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1519473565 362 DLA----PSCAGFLFGVANTAGALAGVVGVCLGGYLMETTGSWTCLFNLVAIISNLGLCTFL 419
Cdd:cd17320 318 SLAlepfPHVAGTASALLGFLQFLIGALAGALVGLLPNGTALPMGLLILVLGLLALLLLILL 379
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
50-300 |
5.97e-10 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 60.64 E-value: 5.97e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 50 SMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSAsawgSITAVTpLLAHLSSAHLAFMTFSRILMG 129
Cdd:COG0738 33 ALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGL----LLMALG-LLLFALAPSYPLLLLALFLLG 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 130 LLQGVYFPALTSLLSQKVRESERAFTySIVGAGSQFGTLLTGAVGSLLLEW---YGWQSIFYFSGGLTLLWVWYVYRYLL 206
Cdd:COG0738 108 LGLGLLDVAANPYVAALGPETAASRL-NLLHAFFSLGALLGPLLGGLLILLglsLSWHLPYLILAVLLLLLALLFLRSKL 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 207 SEkdlilalgvLAQSRPVSRHNRVPWRRLFRKPAVWAAVVSQLSAACSFFILLSWLPTFFEETF--PDAKGWIFNVVPWL 284
Cdd:COG0738 187 PE---------IEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLglSEATAALGLSLFWG 257
|
250
....*....|....*.
gi 1519473565 285 VAIPASLFSGFLSDHL 300
Cdd:COG0738 258 GMTIGRFLGGFLLKRF 273
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
44-400 |
6.18e-10 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 60.70 E-value: 6.18e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 44 MPICTVSMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGSITAVTPLLAHLSSAHLAFmtf 123
Cdd:cd17329 19 WPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIAL--- 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 124 srILMGLLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEwYGWQSIFYFSGGLTLLWVWYVYR 203
Cdd:cd17329 96 --VLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLL-YSFRLLFLAAAVLFLLAALVLLF 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 204 YLLSEKdlilalgvLAQSRPVSRHNRVPWRRLFRKPAVWAAVVSQLSAACSFFILLSWLPTFFEETFPDAkgwiFNVVPW 283
Cdd:cd17329 173 LLPETR--------PKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLG----ESLLGL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 284 LVAIPASLFSGFLsdHLINQGYRAITVRKLMqGMGLGLSSVFALCLGHTSSFCESVVFAS-ASIGlQTFNHSGISVNIQD 362
Cdd:cd17329 241 LLALNALLIVLLQ--FPVARLVERFRLRKIL-MIGILLFAIGFAVLAFANTLAVLILAMIvLTLG-EMLVFPAVQTLVAA 316
|
330 340 350
....*....|....*....|....*....|....*....
gi 1519473565 363 LAP-SCAGFLFGVANTAGALAGVVGVCLGGYLMETTGSW 400
Cdd:cd17329 317 LAPpDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPG 355
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
53-422 |
6.54e-10 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 60.30 E-value: 6.54e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 53 QDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLsasawGSITAVTPLLAHLSSAHLAFMTFSRILMGLLQ 132
Cdd:cd17489 24 HDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLI-----GLLIFALATLLYLLATSVALLLVLRLIHGIGW 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 133 GVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLwvwyvyryllsekDLI 212
Cdd:cd17489 99 GAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALL-------------ALL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 213 LALGVLAQSRPV---SRHNRVPWRRLFRKpAVWAAVVSQLSAACSFFILLSWLPTFFEETFPDAKGWIFNVVPwLVAIPA 289
Cdd:cd17489 166 LVFLVKDPPPVAaeeAEAGTRAFRRLVEK-KVLPPALILFLASIAYGAISTFLPLYAAERGISNAGLFFTVYA-IALLLS 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 290 SLFSGFLSDHLinQGYRAITVrklmqgmGLGLSSVFALCLGHTSSFCESVVFAS-ASIGLQTFNHSGISVNIQDLAPSCA 368
Cdd:cd17489 244 RPFSGKLSDRK--GPKTVIIP-------GLLLLALGLLLLSFAGSPWMLLLAAVlYGLGFGLLFPALQALAVDLVPPHRR 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1519473565 369 GFLFGVANTAGALAGVVGVCLGGYLMETTGsWTCLFNLVAIISNLGLCTFLVFG 422
Cdd:cd17489 315 GAANGTFFIFFDLGIGLGGLLLGLVAELFG-YRAMFLLAAVVVLLALVLYIFLL 367
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
50-394 |
8.65e-10 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 59.88 E-value: 8.65e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 50 SMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASawgsITAVTPLLAHLSSAhLAFMTFSRILMG 129
Cdd:cd17321 21 TIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLA----LFGLASLLCALAPS-LAFLIAARALQG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 130 LLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSggltllwvwyvyryllsek 209
Cdd:cd17321 96 IGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLIN------------------- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 210 dLILALGVLAQSRpvsrhnrvpwrrlfrkpAVWAAVVSQLSAACSFFILLSWLPTFFEETF---PDAKGWIFnvVPWLVA 286
Cdd:cd17321 157 -VPIGLVALLLAR-----------------TFSGAVLAAFLLGAALGGLLFLLPLYLQGVLgysPLQAGLAL--LPLALA 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 287 IP-ASLFSGFLSDHLinqGYRAITVrklmQGMGLGLSSVFALCLGHTSSFCESVVFASA--SIGLQTFNHSGISVNIQDL 363
Cdd:cd17321 217 MLvAAPLAGRLADRF---GPRLVLV----AGLLLTAVGLLLLALLGADSSVWLLLPGLVllGLGLGLFATPLTNAALSSV 289
|
330 340 350
....*....|....*....|....*....|.
gi 1519473565 364 APSCAGFLFGVANTAGALAGVVGVCLGGYLM 394
Cdd:cd17321 290 PKEKAGAASGILNTARQLGGALGVALLGALL 320
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
48-410 |
1.00e-09 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 59.92 E-value: 1.00e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 48 TVSMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGSITAVTPLlahlsSAHLAFMTFSRIL 127
Cdd:cd17316 24 VLAAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGL-----LPTPILLLVLRFL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 128 MGLLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLL----EWYGWQSIFYFSGGLTLLWVWYvyr 203
Cdd:cd17316 99 QGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIpllsGDWGWRILFLIGALPALLALLL--- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 204 yllsekdlilalgvlaqsrpvsrhnrvpWRRLFRKPAVWAAVVSqlsaacSFFILLSWLPTFFEETFPDAKGWIFNVVPW 283
Cdd:cd17316 176 ----------------------------RRRTLLLILLWFFISF------GYYGLTTFLPTYLQTVLGLSPATSSLYLLL 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 284 --LVAIPASLFSGFLSDHLinqgyraitVRKLMQGMGLGLSSVFALCLGhtSSFCESVVFASASIGLQTFNHSGISVNIQ 361
Cdd:cd17316 222 isLGALVGALIAGLLSDRI---------GRKKTLVIGLILSGILALPLF--YLLSGSPTLLLLLLFILSFFVGGVWGALY 290
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1519473565 362 DLAP-----SCAGFLFGVANTAGALAGVVGVCLGGYLMETTGSWTCLFNLVAII 410
Cdd:cd17316 291 AYLAelfptEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALL 344
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
51-196 |
1.06e-09 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 59.88 E-value: 1.06e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 51 MSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGSITAVTpLLAHLSSAHLAFMTFsrILMGL 130
Cdd:COG2271 207 LVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALL-LLALLPSPALAIALL--FLAGF 283
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1519473565 131 LQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLL 196
Cdd:COG2271 284 GLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALL 349
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
62-398 |
6.38e-09 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 57.63 E-value: 6.38e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 62 AGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGSITAVTPLLAHLSSAHLAFMTFSRILMGLLQGVYFPALTS 141
Cdd:cd06173 36 VGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 142 LLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLWVWyvyryllsekdLILALGVLAQS 221
Cdd:cd06173 116 LLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSAL-----------LLLFIRRPPPA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 222 RPVSRHNRVP------WRRLFRKPAVWAAVVSQLSAACSFFILLSWLPTFFEETFPDAKGW--IFNVVPWLVAIPASLFS 293
Cdd:cd06173 185 APGESSSLLLrdlregLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGygLLLAAFGVGALLGALLL 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 294 GFLSDHLINqgyraitvRKLMQGmGLGLSSVFALCLGHTSSFCESVV-FASASIGLQTFNHSGISVNIQDLAPSCAGFLF 372
Cdd:cd06173 265 GRLSKRRRR--------GRLLLI-GALLLGLALLVLGLSPSLWLLLAaLFLLGLAGGLFNVPLNTLLQLRVPDELRGRVF 335
|
330 340
....*....|....*....|....*.
gi 1519473565 373 GVANTAGALAGVVGVCLGGYLMETTG 398
Cdd:cd06173 336 SVYNALNSGAMPLGALLAGLLADALG 361
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
51-394 |
2.11e-08 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 55.66 E-value: 2.11e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 51 MSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASawgsITAVTPLLAHLSSAhLAFMTFSRILMGL 130
Cdd:cd17504 22 IQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLA----IYTAGSLLAAFAPN-LPVLIAGRALQGI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 131 LQGVyFPALTSLLSQKVRESERAFTYSIV----GAGSQFGTLLtgavGSLLLEWYGWQSIFYFSGGLTLLwvwyvyryll 206
Cdd:cd17504 97 GGAV-FPLAFALVREEFPPERVPVAQGILsatfGIGAGIGLPL----GGWIVQHLGWRWIFWTAAPVAVL---------- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 207 sekdLILALGVLAqsrpvsrhnrvpwRRLFRKPAVWAAVVSQLSAACSFFILLSWLPTFFEETFPdAKGWIFNVVPWLVA 286
Cdd:cd17504 162 ----LAALVPLID-------------LRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLPTP-TGFGLGITEAGLLL 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 287 IPASL---FSGFLSDHLInqgyRAITVRKLMQ-GMGLGLSSVFALCLGHTSSFCESVVFASASIGLQTFNHSGISVNIQD 362
Cdd:cd17504 224 LPGALvmlIAGPLAGRLI----ARVGPRRVLLiGLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVES 299
|
330 340 350
....*....|....*....|....*....|..
gi 1519473565 363 LAPSCAGFLFGVANTAGALAGVVGVCLGGYLM 394
Cdd:cd17504 300 VPPDRTGIATGMNTVLRTIGSAIGPAIAGAIL 331
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
38-328 |
2.23e-08 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 55.70 E-value: 2.23e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 38 YCARSSMPICTVSMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGSITAVTPLlahlsSAH 117
Cdd:cd17328 12 YMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSF-----APN 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 118 LAFMTFSRILMGLLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLL-LEWYGWQSIFYFSGGLTLL 196
Cdd:cd17328 87 FWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVaQATGGWRWAFRVTGVLGVL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 197 WVwyvyryllsekdLILALGVLAQSRPVSRHNRVP----------WRRLFRKPAVWAAVVSQLSAACSFFILLSWLPTFF 266
Cdd:cd17328 167 LA------------ILLLLFVREPPRGAAEGGVMAkstatsfladLKALAKNPSFILSTLGFTAVSFVTGALAFWAPTFF 234
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1519473565 267 EETFPDAK------GWIFNVVPWLVAIPASLFSGFLSDHLINQGYRAitvRKLMQGMGLGLSSVFALC 328
Cdd:cd17328 235 LRAFGVGDlssadvGLIFGAITCIAGVLGVLLGGILADRLRRKTPRA---DPLVCAVGLLAAAPFLFL 299
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
50-300 |
2.48e-08 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 55.77 E-value: 2.48e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 50 SMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLsasawgsitavTPLLAHLSSAHLAFMT------F 123
Cdd:cd17371 24 ALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVI-----------TILLFAVFTLLCGFAQnywqllI 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 124 SRILMGLLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFG----TLLTGAVGSLLLEWYGWQSIFYFsGGLTLLWVW 199
Cdd:cd17371 93 LRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGwllaTLLAALLFPLLPPEIAWRVLFLL-GALPALLVL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 200 YVYRYlLSEKDLILAlgvlAQSRPVSRHNRVPWRRLFRKPAVWAAVVSQLSAACSFFI---LLSWLPTFFEETFPDAKGW 276
Cdd:cd17371 172 FIRRF-VKEPPQWQA----ARAARRHFADRPSLRELFSPPLLRTTLLASLLATGALGGyygITTWLPSYLTGERGLSFEG 246
|
250 260
....*....|....*....|....*.
gi 1519473565 277 --IFNVVPWLVAIPASLFSGFLSDHL 300
Cdd:cd17371 247 saGYLVVTILGGFLGYLAGGFLADRI 272
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
62-213 |
3.02e-07 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 52.20 E-value: 3.02e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 62 AGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAwgsiTAVTPLLAHLSSaHLAFMTFSRILMGLLqGVYFPALTS 141
Cdd:cd17330 36 VGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAG----SAVSYVLLGLSR-NLWLLFLARFLDGLT-GGNVSVAQA 109
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1519473565 142 LLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLWVWYVYRYLLSEKDLIL 213
Cdd:cd17330 110 YIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFLPPLRRLLL 181
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
75-398 |
3.85e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 52.21 E-value: 3.85e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 75 LTQVVGGHLGDRIGGEK-----VILLSASAWGSITAVTPLLAHLS-SAHLAFMTFSRILMGLLQGVYFPALTSLLSQKVR 148
Cdd:COG2211 61 ITDPLIGALSDRTRTRWgrrrpWILIGAIPLALSFVLLFTAPDLSpTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTP 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 149 ES-ERAFTYSIVGAGSQFGTLLTGAVGSLLLEWY------GWQSIFYFSGGLTLLWVWYVYRYLlsekdlilalgvlaQS 221
Cdd:COG2211 141 DYeERTRLSSWRFAFAGLGGLLASVLPPPLVAAFggdaalGYRLTALIFAVLGLLAFLLTFFGT--------------KE 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 222 RPVSRHNRVP----WRRLFRKPAVWAAVVSQLSAACSFFILLSWLPTFFEETFPDAKGW--IFNVVPWLVAIPASLFSGF 295
Cdd:COG2211 207 RPVPEEEKVSlkesLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALvgLLLALYFLAALLGAPLWPR 286
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 296 LSDHLinqGYRAiTVRKLMQGMGLGLSSVFALCLGHTSSFCesVVFASASIGLQTFNhsGISVNIQ-DLAP--------S 366
Cdd:COG2211 287 LAKRF---GKKK-AFIIGLLLAALGLLLLFFLGPGNLWLLL--VLAALAGIGLGAIL--VLPWAMLaDVVDydewktgrR 358
|
330 340 350
....*....|....*....|....*....|..
gi 1519473565 367 CAGFLFGVANTAGALAGVVGVCLGGYLMETTG 398
Cdd:COG2211 359 REGLYFGIFTFAIKLGQALAGALAGLLLALFG 390
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
62-246 |
6.31e-07 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 51.11 E-value: 6.31e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 62 AGIVLSSFFWGYCLTQVVGGHLGDRIGgEKVILLSASAWGSITAVtpLLAHLSSAHlaFMTFSRILMGLLQGvYFPALTS 141
Cdd:cd17391 38 SGLAFSSTFLVSAIFSPIWGRLADRYG-RKPMLLRASLGMAIVIG--LMAFVTNVW--QLLILRLLQGVFSG-YVPNATA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 142 LLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLWVwyvyryllsekdLILALGVLAQS 221
Cdd:cd17391 112 LIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLLFLAF------------LLTLFFVKEDF 179
|
170 180
....*....|....*....|....*....
gi 1519473565 222 RPVSRHNRVP----WRRLFRKPAVWAAVV 246
Cdd:cd17391 180 KPVEKKKMVStkevWNSVPNPSLLISLFV 208
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
62-200 |
6.78e-07 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 51.11 E-value: 6.78e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 62 AGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLsASAWGSITAVTPLLAHLSSAHLAFmtfsRILMGLLQGVYFPALTS 141
Cdd:cd17391 242 SGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLG-ALLASALLYIPQAFVQTPWQLGIL----RFLLGLATGGLLPAINS 316
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1519473565 142 LLSQKVRESE--RAFTY--SIVGAGSQFGTLLTGAVGSllleWYGWQSIFYFSGGLTLL---WVWY 200
Cdd:cd17391 317 LLAKITPKEVagRIFGYnqSFQYLGNVAGPLLGSAIAA----HFGYRAVFVVTALLVLLnaiWSFI 378
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
38-196 |
7.08e-07 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 50.87 E-value: 7.08e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 38 YCARSSMPICTVSMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAwgsiTAVTPLLAHLSSAH 117
Cdd:cd17488 16 YLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIA----TGIINILFGFSSSL 91
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1519473565 118 LAFMTFsRILMGLLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLL 196
Cdd:cd17488 92 WAFAVL-WTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTYGWRAGMYVPGIIAIL 169
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
51-203 |
9.27e-07 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 50.65 E-value: 9.27e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 51 MSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGH-LGDRIGGEKVILLSASAWGSITAVTPLLAHLssahlAFMTFSRILMG 129
Cdd:cd17474 225 LELLYGISPIIIGLLFAGWSVLLALGSLFVGRlLKKRFGARRILVIGLLLYALSLLLLGFVPSL-----ALLLIAIVLFG 299
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1519473565 130 LLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLWVWYVYR 203
Cdd:cd17474 300 LGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLAL 373
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
63-196 |
2.32e-06 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 46.87 E-value: 2.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 63 GIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASawgsITAVTPLLAHLSSaHLAFMTFSRILMGLLQGVYFPALTSL 142
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLF----IFVLSTAMFALSS-NITVLIIARFLQGFGAAFALVAGAAL 75
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1519473565 143 LSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLL 196
Cdd:TIGR00880 76 IADIYPPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALA 129
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
38-393 |
2.75e-06 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 49.16 E-value: 2.75e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 38 YCARSSMPICTVSMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEK--VILLSASAwgsitAVTPLLAHLSS 115
Cdd:cd17345 16 YLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRflAIGLILSA-----IINILIGFVPS 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 116 AH--LAFMTFSRILMGLLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYG---WQSIFYFS 190
Cdd:cd17345 91 ATssVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFGdgwWRGAFIFP 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 191 GGLTLLWVWYVYRYL-----------LSE--KDLILALGVLAQSRPVSRHnRVPWRRLFRKPAVWAAVVSQLSAACSFFI 257
Cdd:cd17345 171 AIIAIIVAVIVLFLGkdtpeseglppIEEykGDYPEEADGEEEEQELSAW-EIFVKYVLKNKLLWYIAIANVFVYLVRYG 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 258 LLSWLPTFFEEtfpdAKGWIFNVVPW------LVAIPASLFSGFLSDHLINqGYRAITVRklmqgmgLGLSSVFALCLGH 331
Cdd:cd17345 250 ILDWAPTYLSE----VKGFSKAQAMWafslfeWAAIPGTLLAGWLSDKLFK-GRRAPTGI-------IFMILVIVALIVY 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1519473565 332 TSSFCESVVFASASI------GLQTFnhsgISVNIQDLAPSCAgflfgvantAGALAGVVGVClgGYL 393
Cdd:cd17345 318 WLAPNVLVDLIALIAlgfliyGPVML----IGLQALELVPKKA---------AGTAAGLTGLF--GYL 370
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
53-196 |
9.36e-06 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 47.54 E-value: 9.36e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 53 QDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGSITAvtpLLAHLSSAHLAFMTFsrILMGLLQ 132
Cdd:cd17370 227 QELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYL---GFALGSSLWLLLLGF--ILWGLYM 301
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1519473565 133 GVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLL 196
Cdd:cd17370 302 GAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALI 365
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
78-298 |
1.40e-05 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 47.14 E-value: 1.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 78 VVGGHLGDRIGGEKVILLSASAWGSITAVTPLLAHLSSAHLA---FMTFSRILMGLLQGVYFPALTSLLSQKVRESERAF 154
Cdd:cd17369 62 VVFGHFGDRIGRKKTLVLTLLLMGIATFLIGLLPTYAQIGILapiLLVLLRLLQGLALGGEWGGAVLMAVEHAPPKRRGF 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 155 TYSIVGAGSQFGTLLTGAVGSLL---------LEWyGWQSIFYFSGGLTL--LWVwyvyRYLLSEKDlilalgVLAQSRP 223
Cdd:cd17369 142 YGSFPQLGAPVGLLLATGVFLLLsallsdeafLSW-GWRIPFLLSAVLVAvgLYI----RLRLEETP------VFRRAKE 210
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1519473565 224 VSRHNRVPWRRLFRK--PAVWAAVVSQLSAACSFFILLSWLPTFFEETFPDAKGWIFNVVPW--LVAIPASLFSGFLSD 298
Cdd:cd17369 211 AGQVVRAPLVEVLRRhwRALLLAIGLRLAENVLFYLFTTFALSYATQTLGVDRSTVLLAVLIasVVAAITIPLFGWLSD 289
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
62-383 |
2.87e-05 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 46.00 E-value: 2.87e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 62 AGIVLSSFFwgycltqvvgGHLGDRIGGEKVILLSASAWGSITAVtpLLAHLSSaHLAFMTFSRILMGLLqGVYFPALTS 141
Cdd:cd17471 44 SGIVVSQWL----------GRLSDRGGDRKPLILLALLAGALGYL--LFAFLRN-YWVLLLVGVVLLSLG-AAAFPQLFA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 142 L---LSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLWVWYVYRYLLSEKdlilalgvl 218
Cdd:cd17471 110 LareYADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFLLPSVK--------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 219 aQSRPVSRHNRVPWRRLFRKPAVWAAVVSQLSAACSFFILLSwLPTF------FEETFPdakGWIFNVVPwLVAIPASLF 292
Cdd:cd17471 181 -PPAQKATPASSLVKAPVNRRLLLLFAAFTLLFAANSMYIIA-MPLYvtnelgGSESWV---GLLFGLAA-ALEIPIMLL 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 293 SGFLSdhlinqgyRAITVRKLMQGMGLGLSSVFALCLGHTSSfcesvvfaSASIGLQTFNHSGISVN-------IQDLAP 365
Cdd:cd17471 255 AGLLA--------KRFGKRRLLLAGFLAGVLFYLGLALATSL--------WQLIALQLLNAIFIGITaglgisyFQDLMP 318
|
330 340
....*....|....*....|.
gi 1519473565 366 SCAGF---LFGVANTAGALAG 383
Cdd:cd17471 319 GQPGLattLYSNASRIGSLLG 339
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
50-287 |
4.07e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 45.64 E-value: 4.07e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 50 SMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSAsawgSITAVTPLLAHLSSahlafmTFSRILMG 129
Cdd:cd17474 24 AIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGL----LLFGIGGLLCGLSD------SFALLLAG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 130 -LLQGVYFPALTS----LLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWyGWQSIFYFSGGLTLLWVWYVYRY 204
Cdd:cd17474 94 rALQGIGAAGLGPlaltLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAI-SWRYPFFLLAALIPVAFLAILFL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 205 LLSEKdlilalgvlAQSRPVSRHNRVPWRRLFRKPAVWAAVVSQLSAACSFFILLSWLPTFFEETF---PDAKGWIFnvV 281
Cdd:cd17474 173 LPEPK---------EKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYgisPIIIGLLF--A 241
|
....*.
gi 1519473565 282 PWLVAI 287
Cdd:cd17474 242 GWSVLL 247
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
49-420 |
8.64e-05 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 44.47 E-value: 8.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 49 VSMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLsasawGSITAVTPLLAHLSSAHLAFMTFSR-IL 127
Cdd:cd17352 27 VELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIA-----GGLLAALGLLLSSFATSLWQLYLTYgVL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 128 MGLLQGVYFPALTSLLSQKVrESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLwvwyvyrylls 207
Cdd:cd17352 102 GGLGLGLIYSPAIVIVGQYF-EKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLILGGLCLN----------- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 208 ekdlILALGVLAqsrpvsrhnrvpwrRLFRKPAVWAAVVSQLSAACSFFILLSWLPTFFEET-FPDAKGW----IFNVvp 282
Cdd:cd17352 170 ----LCVCGLLL--------------RLLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSLgIDESDAAfllsIIGI-- 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 283 wlVAIPASLFSGFLSDHlinQGYRAITVRKLMQGMgLGLSSVFALCLGHTSSFCESVVFASASIGlqtFNHSGISVNIQD 362
Cdd:cd17352 230 --SDIVGRILLGLLADK---PRIGRLYLYIFTLLI-LGLSLLAFPLATTYVGLIVFSVLFGFCSG---SYSSLTPVILAD 300
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1519473565 363 LAP----SCAgflFGVANTAGALAGVVGVCLGGYLMETTGSWTCLF---NLVAIISnlGLCTFLV 420
Cdd:cd17352 301 LVGleklSNA---YGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFyfcGACLLLS--GVLLFLL 360
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
55-196 |
1.16e-04 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 44.13 E-value: 1.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 55 FGWNKKEAGIVLSSFFWGYCLTQVVG-GHLGDRIGGEKVILLSAsawGSITAVTPLLAHLSSahLAFMTFSRILMGLLQG 133
Cdd:cd17331 238 FGLTPEENGYLMSYAGVLGMVVQGLLvGPLTKRFGERSLLKLSV---ALLAIGYLLLAFVTT--VWQLLVLLLPLVIGGS 312
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1519473565 134 VYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLL 196
Cdd:cd17331 313 VLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPSFGLLGAAINGL 375
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
51-203 |
1.75e-04 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 43.69 E-value: 1.75e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 51 MSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAwgsITAVTPLLAHLSSAHLAFMTFsrILMGL 130
Cdd:COG0738 237 LKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALL---AAVGLLLALLAPGPWLALIGL--ALVGL 311
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1519473565 131 LQGVYFPALTSLLSQKVRESeRAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLWVWYVYR 203
Cdd:COG0738 312 GLSLMFPTIFSLALDGLGKR-TAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALA 383
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
55-209 |
2.00e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 43.35 E-value: 2.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 55 FGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGSITAVTPLLAHlssAHLAFMTFSRILMGLLQGV 134
Cdd:COG2211 259 LGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGP---GNLWLLLVLAALAGIGLGA 335
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 135 YFPALTSLLSQKVRESE-------RAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQS---------------IFYFSGG 192
Cdd:COG2211 336 ILVLPWAMLADVVDYDEwktgrrrEGLYFGIFTFAIKLGQALAGALAGLLLALFGYVAgaaqspsaltgirllFFLLPAV 415
|
170
....*....|....*..
gi 1519473565 193 LTLLWVWYVYRYLLSEK 209
Cdd:COG2211 416 LLLLAALLLLFYPLTRE 432
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
56-196 |
2.39e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 42.93 E-value: 2.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 56 GWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSAsawgSITAVTPLLAHLSSAHLAFMTFSRILMGLLQGVY 135
Cdd:cd17477 219 GLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCA----LLGALAALLLPLVPGLPLALLVLLFLWGGAAGPL 294
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1519473565 136 FPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLL 196
Cdd:cd17477 295 YTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALL 355
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
50-205 |
2.60e-04 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 43.14 E-value: 2.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 50 SMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSasawGSITAVTPLLAHLSSAHLAFMtfsriLMG 129
Cdd:TIGR00710 30 EIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLG----LFIFALSSLGLALSNNIETLL-----VLR 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 130 LLQGVYFPALTSLLSQKVRES----ERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLWVWYVYRYL 205
Cdd:TIGR00710 101 FVQAFGASAGSVISQALVRDIypgeELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFIL 180
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
51-420 |
2.66e-04 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 42.98 E-value: 2.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 51 MSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGsitavtplLAHLSSAH-----LAFMTFSr 125
Cdd:cd17353 29 LSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFG--------LGFILSAFaislpLLFLGYG- 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 126 ILMGLLQGVYFPALTSLLsQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLWVWYVYRYL 205
Cdd:cd17353 100 VLGGIGAGIGYITPVSTA-VKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGIIFLIIIVIGAFLI 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 206 LSEKDLILALGVLA-QSRPVSRHNRVPWRRLFRKPAVWAAVVSQLSAACSFFILLSWLPTFFEETFPDAKGWIFNVVPWL 284
Cdd:cd17353 179 RDPPKGWVPPGVDPlANNAENSPRDYTPREMLRTPTFWLLWLMFFLNATAGLMLIGQAKPIGQEFAGLDAGIAALAVSIL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 285 VAIPAS--LFSGFLSDHLinQGYRAITVrklmqgmGLGLSSVFALCLGHTSSFCESVVFASASIGlqtFNHSGISVniqd 362
Cdd:cd17353 259 SIFNGGgrPFWGWLSDKI--GRKNTLSI-------AFLIQGVAMFLLPFIGSVAVLFVLGVALIG---FCYGGGFA---- 322
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1519473565 363 LAPSCAGFLFGVAN---------TAGALAGVVGVCLGGYLmETTGSWTCLFNLVAIISNLGL-CTFLV 420
Cdd:cd17353 323 LFPALTADFFGTKNagtnygllyTAKGVGGLIGPIIAAYV-LYTGGYNAAFIIAAALSLVALaLALLL 389
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
50-190 |
2.87e-04 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 42.95 E-value: 2.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 50 SMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASawgsITAVTPLLAHLSSaHLAFMTFSRILMG 129
Cdd:cd17503 21 TIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALA----LFTLGSLLCGLAP-NLASLIIFRILQG 95
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1519473565 130 LLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFS 190
Cdd:cd17503 96 FGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYIN 156
|
|
| PTR2 |
COG3104 |
Dipeptide/tripeptide permease [Amino acid transport and metabolism]; |
55-203 |
3.44e-04 |
|
Dipeptide/tripeptide permease [Amino acid transport and metabolism];
Pssm-ID: 442338 [Multi-domain] Cd Length: 479 Bit Score: 42.88 E-value: 3.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 55 FGWNKKEAGIVLSSFF-WGYcLTQVVGGHLGDR-IGGEKVILlsasaWGSITAVtplLAHLS---SAHLAFMTFSRILMG 129
Cdd:COG3104 50 LGLSEADAAAIYGAYTaLVY-LTPLLGGWLADRlLGQRRAIL-----LGGILMA---LGHFLlalPGGVTLFYLGLALIA 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 130 LLQGVYFPALTSLLSQKVRESER----AFT--YSIVGAGSQFGTLLTGAVGslllEWYGWQSIFYFSG-GLTLLWVWYVY 202
Cdd:COG3104 121 VGNGLFKPNISSLVGQLYDPGDPrrdaGFTifYMGINIGAFLAPLLCGYLG----EKYGWHYGFGAAAiGMLIGLIIFLL 196
|
.
gi 1519473565 203 R 203
Cdd:COG3104 197 G 197
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
51-196 |
7.37e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 41.41 E-value: 7.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 51 MSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLsasaWGSITAVTPLLAHLSSAHLAFMTFSRILMGL 130
Cdd:cd17330 201 LKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLR----LGLLLAIIGLLLLPFASSVPLLVLAAAILAF 276
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1519473565 131 LQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLL 196
Cdd:cd17330 277 GTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLI 342
|
|
| MFS_DtpA_like |
cd17346 |
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ... |
55-218 |
8.00e-04 |
|
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340904 [Multi-domain] Cd Length: 399 Bit Score: 41.41 E-value: 8.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 55 FGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRI-GGEKVILLSasawGSITAVTPLLAHLSSAHLAFMTFSRILMGLLQG 133
Cdd:cd17346 35 DGFSEADAASIYGAYTALVYLTPIIGGWLADKVlGARRTVFIG----GILMALGYLLLALSPFSVSMLYLGLALIIVGNG 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 134 VYFPALTSLLSQKVRESE----RAFT--YSIVGAGSQFGTLLTGavgsLLLEWYGWQSIFYFSGG---LTLLWVWYVYRY 204
Cdd:cd17346 111 LFKPNISSLVGKLYDENDprrdSGFSifYMGINLGAFLAPLLCG----TLGDNYGYHYGFGLAAVgmlLGLLIFLLGRKK 186
|
170
....*....|....
gi 1519473565 205 LLsEKDLILALGVL 218
Cdd:cd17346 187 LL-ERKKMLAIIIL 199
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
81-354 |
1.20e-03 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 41.13 E-value: 1.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 81 GHLGDRIGGEKVILLSAS--AWGS-ITAVTPLLAHLSSAHLAFMTFSRILMGLLQGVYFPALTSLLSQKVRESERAFTYS 157
Cdd:cd17367 61 GRLADRIGRRAALTLSVSlmAAGSlVIAVTPTYATIGIWAPIILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSS 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 158 IVGAGSQFGTLLTGAVGSLL--------LEWYGWQSIFYFSGGLTLLWVWYVYRYLLSEKDLILALGVLAQSRpvsrhnr 229
Cdd:cd17367 141 FQYVTLIGGQLLALGVLLVLqhtlgedqMAAWGWRIPFLLGGVLAVVVLWLRRGLEETESFEAIAESNEASAG------- 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 230 vPWRRLFRKPAVWAAVVSqLSAACS--FFILLSWLPTFFEET--FPDAKGWIFNVVPWLVAIPASLFSGFLSDHlinqgy 305
Cdd:cd17367 214 -TLRELRRHPRELLLVVG-LTAGGTlaFYTWTTYLQKFLVNTagFSKGDATWITTAALLVFMLLQPLGGRLSDR------ 285
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 1519473565 306 raITVRKLMQGMGLG--LSSVFAL-CLGHTSSFCESVVFASASIGLQTFNHS 354
Cdd:cd17367 286 --IGRRPLLLFFGIGgtLATVPLLsALDHTDSPYTAFALVLVGLVFLSGYTS 335
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
59-196 |
1.33e-03 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 40.78 E-value: 1.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 59 KKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEkvILLSASAWGSiTAVTPLLAHLSSahLAFMTFSRILMGLLQGVYFPA 138
Cdd:cd17343 37 KSDLGLITSSQSLAYAISKFIGGVLSDQISAR--WLFSSGLVLS-GLTTVAFSGSSS--VWVFSILWFLNGLAQGLGWPP 111
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1519473565 139 LTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLL 196
Cdd:cd17343 112 CAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSYGWRSTLSISGTVAVV 169
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
72-197 |
1.51e-03 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 40.71 E-value: 1.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 72 GYCLTQ----VVGGHLGDrIGGEKVILLSASAWgsiTAVTPLLAHLSsAHLAFMTFSRILMGLLQGVYFPALTSLLSQKV 147
Cdd:cd17476 41 SYSLTVgtfiLIFGRLGD-IYGHKKMFVIGSFW---FAIWSLIAGFS-PNFIFFIICRALQGLGPAFLLPNAMALLGRTY 115
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1519473565 148 RES-ERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLW 197
Cdd:cd17476 116 PPGpRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLAILAAIV 166
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
81-187 |
2.38e-03 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 40.10 E-value: 2.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 81 GHLGDRIGGEKVILLSASAWGsitaVTPLLAHLSSAHLAFMTfSRILMGLLQGVYFPA-LTSLLSQKVRESERAFTYSIV 159
Cdd:PRK14995 62 GALGDRIGFKRLLMLGGTLFG----LASLAAAFSPTASWLIA-TRALLAIGAAMIVPAtLAGIRATFTEEKQRNMALGVW 136
|
90 100 110
....*....|....*....|....*....|..
gi 1519473565 160 GA----GSQFGTLltgaVGSLLLEWYGWQSIF 187
Cdd:PRK14995 137 AAvgsgGAAFGPL----VGGILLEHFYWGSVF 164
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
51-414 |
3.06e-03 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 39.70 E-value: 3.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 51 MSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAwgsITAVTPLLAHLSSAHLAFMTFSrILMGL 130
Cdd:cd17314 29 WQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIM---VLAGYTYLSYVFNSFPLSYACF-VFIGA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 131 LQGVYFPALTSLLSQKVrESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGL--TLLWVWYVYRYLLSE 208
Cdd:cd17314 105 GTGILYGSAVLVTTQYF-PDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVYTILGILaaIVLSVVSLLGFKEPP 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 209 KdlilalgvlAQSRPVSRHNRVPWR-RLFRKPAVWAAVVSQLSAACSFFILLSWLPTFFEETFPDAKGwifnVVPWLVAI 287
Cdd:cd17314 184 D---------NQARLHVQKKKTQTMgEIFRDKVFWILFIAIFLVLIGGFLFIANMASLVRSLQLDAPS----FVTKLMSI 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 288 PA------SLFSGFLSDHLINqgyRAITVRKLMQGMGLGLSSV-FALCLGHTSSFCESVVFASASIGLQTFNHSGISVNI 360
Cdd:cd17314 251 YGlfnafgRLLWGIVADFFGG---RLSTLSILLTILGLGLCAFlFLLKMTPVGLVLTGSLLGFSYGGLFTVYPATVSTVF 327
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1519473565 361 QDlapSCAGFLFGVANTAGALAGVVGVCLGGYLMETTGSWTCLFNLVAIISNLG 414
Cdd:cd17314 328 GT---ESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIYAVIVFLA 378
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
50-130 |
3.14e-03 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 39.47 E-value: 3.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 50 SMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSA-----SAWGSitAVTPllahlssaHLAFMTFS 124
Cdd:cd17359 26 FLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAvlffiSALGS--AFSP--------NFTIFIIA 95
|
....*.
gi 1519473565 125 RILMGL 130
Cdd:cd17359 96 RIIGGL 101
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
85-205 |
3.87e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 39.13 E-value: 3.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 85 DRIGGEKVILLSASAWGSITAVTPLLAHLSsahlaFMTFSRILMGLLQGVYFPALTSLLSQKVRESERA----FTYSIVG 160
Cdd:cd17490 256 KKLGERNTIIIGFLLLGAYCFLIPFAPNLT-----LLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRStamgFFQAIYA 330
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 1519473565 161 AGSQFGTLLTGAVGslllEWYGWQSIFYFSGGLTLLWVWYVYRYL 205
Cdd:cd17490 331 LGMFLGPVLVGIIS----EAFGLQTGFFVIGVIALLAAILSLAYY 371
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
56-142 |
4.33e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 39.08 E-value: 4.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519473565 56 GWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVIllsasaWGSITAVTPLLAHLSSAHLAFMTFSRILMGLLQGVY 135
Cdd:cd17478 226 GYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVI------IASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFAS 299
|
....*..
gi 1519473565 136 FPALTSL 142
Cdd:cd17478 300 FPVTVVL 306
|
|
| |
