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Conserved domains on  [gi|188536036|ref|NP_079119|]
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plasma membrane ascorbate-dependent reductase CYBRD1 isoform 1 [Homo sapiens]

Protein Classification

cytochrome b family protein( domain architecture ID 10171797)

cytochrome b family protein such as formate dehydrogenase subunit gamma or cytochrome b, a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cyt_b561_CYBRD1 cd08765
Vertebrate cytochrome b(561), CYBRD1 gene product; Duodenal cytochrome b or ferric-chelate ...
 36-188 8.37e-92

Vertebrate cytochrome b(561), CYBRD1 gene product; Duodenal cytochrome b or ferric-chelate reductase 3, a cytochrome b(561), as found in vertebrates, which might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. This protein is expressed at the brush border of duodenal enterocytes and may play a role in the uptake of dietary Fe(3+), facilitating its transport into the mucosal cells. It may also be involved in the recycling of extracellular ascorbate in erythrocyte membranes, and act as a ferrireductase in epithelial cells of the respiratory system. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


:

Pssm-ID: 176495  Cd Length: 153  Bit Score: 268.69  E-value: 8.37e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536036  36 EGLGWDGSALEFNWHPVLMVTGFVFIQGIAIIVYRLPWTWKCSKLLMKSIHAGLNAVAAILAIISVVAVFENHNVNNIAN 115
Cdd:cd08765    1 EGLGWDGGAAEFNWHPVLMVIGFIFIQGIAIIVYRLPWTWKCSKLLMKLIHAGLHILAFILAIISVVAVFVFHNAKNIPN 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 188536036 116 MYSLHSWVGLIAVICYLLQLLSGFSVFLLPWAPLSLRAFLMPIHVYSGIVIFGTVIATALMGLTEKLIFSLRD 188
Cdd:cd08765   81 MYSLHSWVGLAAVILYPLQLVLGISVYLLPVAPVRLRAALMPLHVYSGLFIFGTVIATALMGITEKLIFSLKS 153
 
Name Accession Description Interval E-value
Cyt_b561_CYBRD1 cd08765
Vertebrate cytochrome b(561), CYBRD1 gene product; Duodenal cytochrome b or ferric-chelate ...
 36-188 8.37e-92

Vertebrate cytochrome b(561), CYBRD1 gene product; Duodenal cytochrome b or ferric-chelate reductase 3, a cytochrome b(561), as found in vertebrates, which might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. This protein is expressed at the brush border of duodenal enterocytes and may play a role in the uptake of dietary Fe(3+), facilitating its transport into the mucosal cells. It may also be involved in the recycling of extracellular ascorbate in erythrocyte membranes, and act as a ferrireductase in epithelial cells of the respiratory system. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176495  Cd Length: 153  Bit Score: 268.69  E-value: 8.37e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536036  36 EGLGWDGSALEFNWHPVLMVTGFVFIQGIAIIVYRLPWTWKCSKLLMKSIHAGLNAVAAILAIISVVAVFENHNVNNIAN 115
Cdd:cd08765    1 EGLGWDGGAAEFNWHPVLMVIGFIFIQGIAIIVYRLPWTWKCSKLLMKLIHAGLHILAFILAIISVVAVFVFHNAKNIPN 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 188536036 116 MYSLHSWVGLIAVICYLLQLLSGFSVFLLPWAPLSLRAFLMPIHVYSGIVIFGTVIATALMGLTEKLIFSLRD 188
Cdd:cd08765   81 MYSLHSWVGLAAVILYPLQLVLGISVYLLPVAPVRLRAALMPLHVYSGLFIFGTVIATALMGITEKLIFSLKS 153
Cytochrom_B561 pfam03188
Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport ...
 49-185 1.16e-56

Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport protein. It is an integral membrane protein, that binds two heme groups non-covalently. This is a eukaryotic family. Members of the 'prokaryotic cytochrome b561' family can be found in Pfam: PF01292.


Pssm-ID: 427188  Cd Length: 137  Bit Score: 178.57  E-value: 1.16e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536036   49 WHPVLMVTGFVFIQGIAIIVYRLPWTWKCSKLLMKSIHAGLNAVAAILAIISVVAVFENHNVNNIANMYSLHSWVGLIAV 128
Cdd:pfam03188   1 WHPVLMVIGFIFLMGEAILVYRVNSTRRLSKKTKKLLHWILQALALILAVIGLVAVFKFHNLSGIPHFYSLHSWLGLLTV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 188536036  129 ICYLLQLLSGFSVFLLPWAPLSLRAFLMPIHVYSGIVIFGTVIATALMGLTEKLIFS 185
Cdd:pfam03188  81 ILYALQWVGGFVTFLFPGLSKRIRPLLLPLHVFFGLVIFVLAIVTALLGLLEKLIFQ 137
B561 smart00665
Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate ...
 49-178 1.35e-40

Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate for the generation of norepinephrine by dopamine-beta-hydroxylase in the chromaffin vesicles of the adrenal gland. It is a transmembrane heme protein with the two heme groups being bound to conserved histidine residues. A cytochrome b-561 homologue, termed Dcytb, is an iron-regulated ferric reductase in the duodenal mucosa. Other homologues of these are also likely to be ferric reductases. SDR2 is proposed to be important in regulating the metabolism of iron in the onset of neurodegenerative disorders.


Pssm-ID: 214769  Cd Length: 129  Bit Score: 137.36  E-value: 1.35e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536036    49 WHPVLMVTGFVFIQGIAIIVYRlPWTWKCSKLLMKSIHAGLNAVAAILAIISVVAVFENHNVNNIANMYSLHSWVGLIAV 128
Cdd:smart00665   1 LHPVLMILGFGFLMGEAILVAR-PLTRFLSKPTWFLLHVVLQILALVLGVIGLLAIFISHNESGIANFYSLHSWLGLAAF 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 188536036   129 ICYLLQLLSGFSVFLLPWAPLSLRAFLMPIHVYSGIVIFGTVIATALMGL 178
Cdd:smart00665  80 VLAGLQWLSGFLRPLPPGLPSKYRSYLNPYHRFVGLAAFILAIVTIFLGL 129
PLN02680 PLN02680
carbon-monoxide oxygenase
 18-222 3.25e-39

carbon-monoxide oxygenase


Pssm-ID: 215365  Cd Length: 232  Bit Score: 136.85  E-value: 3.25e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536036  18 LVGFLSVIFALVWVLHYREGLGW--DGSALEFNWHPVLMVTGFVFIQGIAIIVYRlpwTWKCSKLLMKSIHAGLNAVAAI 95
Cdd:PLN02680  16 LLGVIVAALVLTWTVHYRGGLALssDNKDLIFNVHPVLMVIGLVLLNGEAMLAYK---TVPGTKNLKKLVHLTLQFLAFC 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536036  96 LAIISVVAVFENHNVNNIANMYSLHSWVGLIAVICYLLQLLSGFSVFLLPWAPLSLRAFLMPIHVYSGIVIFGTVIATAL 175
Cdd:PLN02680  93 LSLIGVWAALKFHNEKGIDNFYSLHSWLGLACLFLFSLQWAAGFVTFWYPGGSRNSRASLLPWHVFFGIYIYALAVATAT 172

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 188536036 176 MGLTEKLIFSLRDPAYSTFPPEGVFVNTLGLLILVFGALIFWIVTRP 222
Cdd:PLN02680 173 TGILEKATFLQSNKVISRYSTEAMLVNSLGILIVVLGGFVILAIVTP 219
 
Name Accession Description Interval E-value
Cyt_b561_CYBRD1 cd08765
Vertebrate cytochrome b(561), CYBRD1 gene product; Duodenal cytochrome b or ferric-chelate ...
 36-188 8.37e-92

Vertebrate cytochrome b(561), CYBRD1 gene product; Duodenal cytochrome b or ferric-chelate reductase 3, a cytochrome b(561), as found in vertebrates, which might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. This protein is expressed at the brush border of duodenal enterocytes and may play a role in the uptake of dietary Fe(3+), facilitating its transport into the mucosal cells. It may also be involved in the recycling of extracellular ascorbate in erythrocyte membranes, and act as a ferrireductase in epithelial cells of the respiratory system. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176495  Cd Length: 153  Bit Score: 268.69  E-value: 8.37e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536036  36 EGLGWDGSALEFNWHPVLMVTGFVFIQGIAIIVYRLPWTWKCSKLLMKSIHAGLNAVAAILAIISVVAVFENHNVNNIAN 115
Cdd:cd08765    1 EGLGWDGGAAEFNWHPVLMVIGFIFIQGIAIIVYRLPWTWKCSKLLMKLIHAGLHILAFILAIISVVAVFVFHNAKNIPN 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 188536036 116 MYSLHSWVGLIAVICYLLQLLSGFSVFLLPWAPLSLRAFLMPIHVYSGIVIFGTVIATALMGLTEKLIFSLRD 188
Cdd:cd08765   81 MYSLHSWVGLAAVILYPLQLVLGISVYLLPVAPVRLRAALMPLHVYSGLFIFGTVIATALMGITEKLIFSLKS 153
Cyt_b561_CG1275_like cd08764
Non-vertebrate eumetazoan cytochrome b(561); Cytochrome b(561), as found in non-vertebrate ...
 24-237 6.30e-72

Non-vertebrate eumetazoan cytochrome b(561); Cytochrome b(561), as found in non-vertebrate eumetazoans, similar to the Drosophila melanogaster CG1275 gene product. This protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176494  Cd Length: 214  Bit Score: 220.28  E-value: 6.30e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536036  24 VIFALVWVLHYREGLGWDGSALEFNWHPVLMVTGFVFIQGIAIIVYRLPWTWKcsKLLMKSIHAGLNAVAAILAIISVVA 103
Cdd:cd08764    1 VVLVGIWLGKFRGGFSWTGPGLQFNWHPLLMVLGLIFLYGNSILVYRVFRNTR--KKRLKLLHAVLHLLAFILAVIGLKA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536036 104 VFENHNVNN--IANMYSLHSWVGLIAVICYLLQLLSGFSVFLLPWAPLSLRAFLMPIHVYSGIVIFGTVIATALMGLTEK 181
Cdd:cd08764   79 VFDSHNLAKppIPNMYSLHSWLGLTAVILFSLQWVGGFVSFLFPGLPETLRAAYLPLHVFFGLFIFVLAVATALLGITEK 158

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 188536036 182 LIFSLrdPAYSTFPPEGVFVNTLGLLILVFGALIFWIVTRPQWKR--PKEPNSTILHP 237
Cdd:cd08764  159 AFFSL--NKYSNLPAEGVLGNFIGIVLVIFGGLVVYLVTEPDYKRieLPEEEELLIQN 214
Cytochrom_B561 pfam03188
Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport ...
 49-185 1.16e-56

Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport protein. It is an integral membrane protein, that binds two heme groups non-covalently. This is a eukaryotic family. Members of the 'prokaryotic cytochrome b561' family can be found in Pfam: PF01292.


Pssm-ID: 427188  Cd Length: 137  Bit Score: 178.57  E-value: 1.16e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536036   49 WHPVLMVTGFVFIQGIAIIVYRLPWTWKCSKLLMKSIHAGLNAVAAILAIISVVAVFENHNVNNIANMYSLHSWVGLIAV 128
Cdd:pfam03188   1 WHPVLMVIGFIFLMGEAILVYRVNSTRRLSKKTKKLLHWILQALALILAVIGLVAVFKFHNLSGIPHFYSLHSWLGLLTV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 188536036  129 ICYLLQLLSGFSVFLLPWAPLSLRAFLMPIHVYSGIVIFGTVIATALMGLTEKLIFS 185
Cdd:pfam03188  81 ILYALQWVGGFVTFLFPGLSKRIRPLLLPLHVFFGLVIFVLAIVTALLGLLEKLIFQ 137
Cyt_b561_CYBASC3 cd08762
Vertebrate cytochrome b(561), CYBASC3 gene product; Cytochrome b ascorbate-dependent 3, as ...
 17-188 9.32e-51

Vertebrate cytochrome b(561), CYBASC3 gene product; Cytochrome b ascorbate-dependent 3, as found in vertebrates, which might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176492  Cd Length: 179  Bit Score: 165.04  E-value: 9.32e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536036  17 LLVGFLSVIFALVWVLHYREGLGWDGSALEFNWHPVLMVTGFVFIQGIAIIVYRLPWTWKCSKLLMKSIHAGLNAVAAIL 96
Cdd:cd08762    5 GILGIACVVLVVHWNQMWRGGFAWDGSSKNFNWHPVLMVTGMVVLYGNAALVYRIPLTWGGPKLPWKLLHAGLLLLAFIL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536036  97 AIISVVAVFENHNVNNIANMYSLHSWVGLIAVICYLLQLLSGFSVFLLPWAPLSLRAFLMPIHVYSGIVIFGTVIATALM 176
Cdd:cd08762   85 TVIGLCAVFNFHNVHHTANLYSLHSWVGICTVALFTCQWVMGFTSFLLPWAPMWLRALVKPIHVFFGAMILVLSIASCIS 164

                        170
                 ....*....|..
gi 188536036 177 GLTEKLIFSLRD 188
Cdd:cd08762  165 GINEKLFFSLKN 176
Cyt_b561 cd08554
Eukaryotic cytochrome b(561); Cytochrome b(561) is a family of endosomal or secretory ...
 46-178 8.83e-45

Eukaryotic cytochrome b(561); Cytochrome b(561) is a family of endosomal or secretory vesicle-specific electron transport proteins. They are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments. This is an exclusively eukaryotic family. Members of the prokaryotic cytochrome b561 family are not deemed homologous.


Pssm-ID: 176489  Cd Length: 131  Bit Score: 148.20  E-value: 8.83e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536036  46 EFNWHPVLMVTGFVFIQGIAIIVYRLPWTwkCSKLLMKSIHAGLNAVAAILAIISVVAVFENHNVNNIANMYSLHSWVGL 125
Cdd:cd08554    1 EFNWHPLLMVIGFVFLMGEALLVYRVFRL--LTKRALKLLHAILHLLAFVLGLVGLLAVFLFHNAGGIANLYSLHSWLGL 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 188536036 126 IAVICYLLQLLSGFSVFLLPWAPLSLRAFLMPIHVYSGIVIFGTVIATALMGL 178
Cdd:cd08554   79 ATVLLFLLQFLSGFVLFLLPLLRLSYRSSLLPFHRFFGLAIFVLAIATILLGI 131
B561 smart00665
Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate ...
 49-178 1.35e-40

Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate for the generation of norepinephrine by dopamine-beta-hydroxylase in the chromaffin vesicles of the adrenal gland. It is a transmembrane heme protein with the two heme groups being bound to conserved histidine residues. A cytochrome b-561 homologue, termed Dcytb, is an iron-regulated ferric reductase in the duodenal mucosa. Other homologues of these are also likely to be ferric reductases. SDR2 is proposed to be important in regulating the metabolism of iron in the onset of neurodegenerative disorders.


Pssm-ID: 214769  Cd Length: 129  Bit Score: 137.36  E-value: 1.35e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536036    49 WHPVLMVTGFVFIQGIAIIVYRlPWTWKCSKLLMKSIHAGLNAVAAILAIISVVAVFENHNVNNIANMYSLHSWVGLIAV 128
Cdd:smart00665   1 LHPVLMILGFGFLMGEAILVAR-PLTRFLSKPTWFLLHVVLQILALVLGVIGLLAIFISHNESGIANFYSLHSWLGLAAF 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 188536036   129 ICYLLQLLSGFSVFLLPWAPLSLRAFLMPIHVYSGIVIFGTVIATALMGL 178
Cdd:smart00665  80 VLAGLQWLSGFLRPLPPGLPSKYRSYLNPYHRFVGLAAFILAIVTIFLGL 129
PLN02680 PLN02680
carbon-monoxide oxygenase
 18-222 3.25e-39

carbon-monoxide oxygenase


Pssm-ID: 215365  Cd Length: 232  Bit Score: 136.85  E-value: 3.25e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536036  18 LVGFLSVIFALVWVLHYREGLGW--DGSALEFNWHPVLMVTGFVFIQGIAIIVYRlpwTWKCSKLLMKSIHAGLNAVAAI 95
Cdd:PLN02680  16 LLGVIVAALVLTWTVHYRGGLALssDNKDLIFNVHPVLMVIGLVLLNGEAMLAYK---TVPGTKNLKKLVHLTLQFLAFC 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536036  96 LAIISVVAVFENHNVNNIANMYSLHSWVGLIAVICYLLQLLSGFSVFLLPWAPLSLRAFLMPIHVYSGIVIFGTVIATAL 175
Cdd:PLN02680  93 LSLIGVWAALKFHNEKGIDNFYSLHSWLGLACLFLFSLQWAAGFVTFWYPGGSRNSRASLLPWHVFFGIYIYALAVATAT 172

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 188536036 176 MGLTEKLIFSLRDPAYSTFPPEGVFVNTLGLLILVFGALIFWIVTRP 222
Cdd:PLN02680 173 TGILEKATFLQSNKVISRYSTEAMLVNSLGILIVVLGGFVILAIVTP 219
Cyt_b561_ACYB-1_like cd08766
Plant cytochrome b(561), including the carbon monoxide oxygenase ACYB-1; Cytochrome b(561), as ...
 45-184 3.04e-38

Plant cytochrome b(561), including the carbon monoxide oxygenase ACYB-1; Cytochrome b(561), as found in plants, similar to the Arabidopsis thaliana ACYB-1 gene product, a cytochrome b561 isoform localized to the tonoplast. This protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), and might be capable of trans-membrane electron transport from intracellular ascorbate to extracellular ferric chelates. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176496  Cd Length: 144  Bit Score: 131.66  E-value: 3.04e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536036  45 LEFNWHPVLMVTGFVFIQGIAIIVYRlpwTWKCSKLLMKSIHAGLNAVAAILAIISVVAVFENHNVNNIANMYSLHSWVG 124
Cdd:cd08766    6 LIFNVHPVLMVIGFIFLAGEAILAYK---TVPGSREVQKAVHLTLHLVALVLGIVGIYAAFKFHNEVGIPNLYSLHSWLG 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536036 125 LIAVICYLLQLLSGFSVFLLPWAPLSLRAFLMPIHVYSGIVIFGTVIATALMGLTEKLIF 184
Cdd:cd08766   83 IGTISLFGLQWLFGFVTFWFPGASRNTRAALLPWHVFLGLAIYYLAIATAETGLLEKLTF 142
PLN02810 PLN02810
carbon-monoxide oxygenase
 1-215 3.73e-36

carbon-monoxide oxygenase


Pssm-ID: 178406  Cd Length: 231  Bit Score: 129.17  E-value: 3.73e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536036   1 MAMEGYWRFLALLGSALLVgfLSVIFALVWVLHYREGLGWDGS--ALEFNWHPVLMVTGFVFIQGIAIIVYRLPWTWKCS 78
Cdd:PLN02810   1 MAVGINALPLTFVAHALAV--IGAIMVLVWSIYYRGGLAWEATnkNLIFNLHPVLMLIGLIIIGGEAIMSYKSLPLKKEV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536036  79 KllmKSIHAGLNAVAAILAIISVVAVFENHNVNNIANMYSLHSWVGLIAVICYLLQLLSGFSVFLLPWAPLSLRAFLMPI 158
Cdd:PLN02810  79 K---KLIHLVLHAIALILGIFGICAAFKNHNESGIANLYSLHSWLGIGIISLYGIQWIYGFIVFFFPGGSTNLRSGSLPW 155

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 188536036 159 HVYSGIVIFGTVIATALMGLTEKLIFsLRDPAYSTFPPEGVFVNTLGLLILVFGALI 215
Cdd:PLN02810 156 HVLFGLFVYILAVGNAALGFLEKLTF-LESGGLDKYGSEALLVNFTAIITILYGAFV 211
Cyt_b561_CYB561 cd08763
Vertebrate cytochrome b(561), CYB561 gene product; Cytochrome b(561), as found in vertebrates, ...
 40-184 1.56e-34

Vertebrate cytochrome b(561), CYB561 gene product; Cytochrome b(561), as found in vertebrates, which might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176493  Cd Length: 143  Bit Score: 122.23  E-value: 1.56e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536036  40 WDGSaLEFNWHPVLMVTGFVFIQGIAIIVYRLpwTWKCSKLLMKSIHAGLNAVAAILAIISVVAVFENHNVNNIANMYSL 119
Cdd:cd08763    1 WSGP-LQFNVHPLCMVLGLVFLCGEALLVYRV--FRNETKRSTKILHGLLHIMALVISLVGLVAVFDYHQANGYPDMYSL 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 188536036 120 HSWVGLIAVICYLLQLLSGFSVFLLPWAPLSLRAFLMPIHVYSGIVIFGTVIATALMGLTEKLIF 184
Cdd:cd08763   78 HSWCGILTFVLYFLQWLIGFSFFLFPGASFTLRSQYKPLHEFFGRALFLSSVGTSLLGLTEKLLF 142
PLN02351 PLN02351
cytochromes b561 family protein
 1-226 4.46e-22

cytochromes b561 family protein


Pssm-ID: 215201  Cd Length: 242  Bit Score: 92.28  E-value: 4.46e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536036   1 MAMEGYWRFLALLGSALLVGFLSVIFALVWVLHYREGLGWDGSALE----FNWHPVLMVTGFVFIQGIAIIVYR-LPWtw 75
Cdd:PLN02351   1 MATVDSSSLLPLLLFARLSGLVVAVLVLYWALFFKSSFLPQSTSQEdlvyAVLHPLLMVIGFILISGEAILVHRwLPG-- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536036  76 kcSKLLMKSIHAGLNAVAAILAIISVVAVFeNHNVNNIANMYSLHSWVGLIAVICYLLQLLSGFSVFLLPWAPLSLRAFL 155
Cdd:PLN02351  79 --SRKTKKSVHLWLQGLALASGVFGIWTKF-HGQDGIVANFYSLHSWMGLICVSLFGAQWLTGFMSFWHRGEMRTTRTTV 155

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 188536036 156 MPIHVYSGIVIFGTVIATALMGLTEKLIFSLRDPAYSTFPPEGVFVNTLGLLILVFGALIFWIVTRPQWKR 226
Cdd:PLN02351 156 LPWHVFLGLYTYGLAVATAETGLLEKLTFLQTKRNVSKHGSESMVVNGLGLGLALLSGIVILAAVLPKYQS 226
Cyt_b561_CYB561D2_like cd08761
Eukaryotic cytochrome b(561), including the CYB561D2 gene product; Cytochrome b(561), as found ...
 21-219 3.40e-14

Eukaryotic cytochrome b(561), including the CYB561D2 gene product; Cytochrome b(561), as found in eukaryotes, similar to and including the human CYB561D2 gene product. CYB561D2 is a candidate tumor suppressor. The protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176491  Cd Length: 183  Bit Score: 69.24  E-value: 3.40e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536036  21 FLSVIFALVWVLHYREGLGWdgsaleFNWHPVLMVTGFVF-IQGIAIIVYRLPWTWKCSKLLMKSIHAGLNAVAAILAII 99
Cdd:cd08761    1 LVAVVFAAFLLYIARPGTSL------FSWHPLLMSLGFLLlMTEALLLLQPTSSLTKLARKTKVRLHWILQLLALLCILA 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536036 100 SVVAVFENHNVNNIANMYSLHSWVGLIAVICYLLQLLSGFSVFllpWAPLSLRAFLMPI-----HVYSGIVIFGTVIATA 174
Cdd:cd08761   75 GLVAIYYNKERNGKPHFTSWHGILGLVTVILIVLQALGGLALL---YPPGLRRGESKAKklkkyHRLSGYVAYLLGLATL 151

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 188536036 175 LMGLTEklifslrdPAYSTFppegvFVNTLGLLILVFGALIFWIV 219
Cdd:cd08761  152 VLGLET--------RWFSKN-----VTHVALWYLALAVALALAGV 183
Cyt_b561_FRRS1_like cd08760
Eukaryotic cytochrome b(561), including the FRRS1 gene product; Cytochrome b(561), as found in ...
 33-179 1.56e-06

Eukaryotic cytochrome b(561), including the FRRS1 gene product; Cytochrome b(561), as found in eukaryotes, similar to and including the human FRRS1 gene product (ferric-chelate reductase 1), also called SDR-2 (stromal cell-derived receptor 2). This family comprises a variety of domain architectures, many of which contain dopamine beta-monooxygenase (DOMON) domains. The protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176490  Cd Length: 191  Bit Score: 47.72  E-value: 1.56e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188536036  33 HYREGLGWDGSALEFNWHPVLMVTGFVFIQGIAIIVYRLPWTWkcSKLLMKsIHAGLNAVAAILAIISVVAVFeNHNVNN 112
Cdd:cd08760   22 LLPNGSSVGSSDTLIKAHGVLMAIAWGILMPIGALLARYFLLG--DPVWFY-LHAGLQLLAVLLAIAGFVLGI-VLVQGG 97

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 188536036 113 IANMYSLHSWVGLIAVICYLLQLLSGfsvFLLPWAPLSLRAFLMPIHVYSGIVIFGTVIATALMGLT 179
Cdd:cd08760   98 GGSLNNAHAILGIIVLALAILQPLLG---LLRPHPGSKKRSIWNWAHRWLGRAALILAIVNIFLGLD 161
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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