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Conserved domains on  [gi|147904340|ref|NP_079498|]
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WD repeat-containing protein 82 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
12-302 3.02e-49

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 168.94  E-value: 3.02e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147904340  12 RVAKVFRENSDKINCFDFSPNGETVISSSDDDSIVLYDCQEGKPKRTLYSKKYGVDLIRYTHAANTVVYSSNkiDDTIRY 91
Cdd:COG2319  111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSD--DGTVRL 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147904340  92 LSLHDNKYIRYFPGHSKRVVALSMSPVDDTFISGSLDKTIRLWDLRSPNCQGLMHLQGKPVCS--FDPEGLIFAAGVNSE 169
Cdd:COG2319  189 WDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSvaFSPDGRLLASGSADG 268

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147904340 170 MVKLYDLRSFDkgPFATFKMQYDRTcewTGLKFSNDGKLILISTNGSFIRLIDAFKGVVMHTFGGYANSkavTLEASFTP 249
Cdd:COG2319  269 TVRLWDLATGE--LLRTLTGHSGGV---NSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA---VRSVAFSP 340

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 147904340 250 DSQFIMIGSEDGKIHVWNGESGIKVAVLDGkHTGPITCLQFNPKFMTFASACS 302
Cdd:COG2319  341 DGKTLASGSDDGTVRLWDLATGELLRTLTG-HTGAVTSVAFSPDGRTLASGSA 392
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
12-302 3.02e-49

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 168.94  E-value: 3.02e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147904340  12 RVAKVFRENSDKINCFDFSPNGETVISSSDDDSIVLYDCQEGKPKRTLYSKKYGVDLIRYTHAANTVVYSSNkiDDTIRY 91
Cdd:COG2319  111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSD--DGTVRL 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147904340  92 LSLHDNKYIRYFPGHSKRVVALSMSPVDDTFISGSLDKTIRLWDLRSPNCQGLMHLQGKPVCS--FDPEGLIFAAGVNSE 169
Cdd:COG2319  189 WDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSvaFSPDGRLLASGSADG 268

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147904340 170 MVKLYDLRSFDkgPFATFKMQYDRTcewTGLKFSNDGKLILISTNGSFIRLIDAFKGVVMHTFGGYANSkavTLEASFTP 249
Cdd:COG2319  269 TVRLWDLATGE--LLRTLTGHSGGV---NSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA---VRSVAFSP 340

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 147904340 250 DSQFIMIGSEDGKIHVWNGESGIKVAVLDGkHTGPITCLQFNPKFMTFASACS 302
Cdd:COG2319  341 DGKTLASGSDDGTVRLWDLATGELLRTLTG-HTGAVTSVAFSPDGRTLASGSA 392
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 15-300 2.30e-46

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 158.27  E-value: 2.30e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147904340  15 KVFRENSDKINCFDFSPNGETVISSSDDDSIVLYDCQEGKPKRTLYSKKYGVDLIRYTHAANTVVYSSNkiDDTIRYLSL 94
Cdd:cd00200    3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSS--DKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147904340  95 HDNKYIRYFPGHSKRVVALSMSPVDDTFISGSLDKTIRLWDLRSPNCQGLMHLQGKPV--CSFDPEGLIFAAGVNSEMVK 172
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVnsVAFSPDGTFVASSSQDGTIK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147904340 173 LYDLRSFdkGPFATFKmqyDRTCEWTGLKFSNDGKLILISTNGSFIRLIDAFKGVVMHTFGGyaNSKAVTlEASFTPDSQ 252
Cdd:cd00200  161 LWDLRTG--KCVATLT---GHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRG--HENGVN-SVAFSPDGY 232

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 147904340 253 FIMIGSEDGKIHVWNGESGIKVAVLDGkHTGPITCLQFNPKFMTFASA 300
Cdd:cd00200  233 LLASGSEDGTIRVWDLRTGECVQTLSG-HTNSVTSLAWSPDGKRLASG 279
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 96-135 6.29e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 6.29e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 147904340    96 DNKYIRYFPGHSKRVVALSMSPVDDTFISGSLDKTIRLWD 135
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
97-135 6.59e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.03  E-value: 6.59e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 147904340   97 NKYIRYFPGHSKRVVALSMSPVDDTFISGSLDKTIRLWD 135
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
12-302 3.02e-49

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 168.94  E-value: 3.02e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147904340  12 RVAKVFRENSDKINCFDFSPNGETVISSSDDDSIVLYDCQEGKPKRTLYSKKYGVDLIRYTHAANTVVYSSNkiDDTIRY 91
Cdd:COG2319  111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSD--DGTVRL 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147904340  92 LSLHDNKYIRYFPGHSKRVVALSMSPVDDTFISGSLDKTIRLWDLRSPNCQGLMHLQGKPVCS--FDPEGLIFAAGVNSE 169
Cdd:COG2319  189 WDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSvaFSPDGRLLASGSADG 268

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147904340 170 MVKLYDLRSFDkgPFATFKMQYDRTcewTGLKFSNDGKLILISTNGSFIRLIDAFKGVVMHTFGGYANSkavTLEASFTP 249
Cdd:COG2319  269 TVRLWDLATGE--LLRTLTGHSGGV---NSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA---VRSVAFSP 340

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 147904340 250 DSQFIMIGSEDGKIHVWNGESGIKVAVLDGkHTGPITCLQFNPKFMTFASACS 302
Cdd:COG2319  341 DGKTLASGSDDGTVRLWDLATGELLRTLTG-HTGAVTSVAFSPDGRTLASGSA 392
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 15-300 2.30e-46

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 158.27  E-value: 2.30e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147904340  15 KVFRENSDKINCFDFSPNGETVISSSDDDSIVLYDCQEGKPKRTLYSKKYGVDLIRYTHAANTVVYSSNkiDDTIRYLSL 94
Cdd:cd00200    3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSS--DKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147904340  95 HDNKYIRYFPGHSKRVVALSMSPVDDTFISGSLDKTIRLWDLRSPNCQGLMHLQGKPV--CSFDPEGLIFAAGVNSEMVK 172
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVnsVAFSPDGTFVASSSQDGTIK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147904340 173 LYDLRSFdkGPFATFKmqyDRTCEWTGLKFSNDGKLILISTNGSFIRLIDAFKGVVMHTFGGyaNSKAVTlEASFTPDSQ 252
Cdd:cd00200  161 LWDLRTG--KCVATLT---GHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRG--HENGVN-SVAFSPDGY 232

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 147904340 253 FIMIGSEDGKIHVWNGESGIKVAVLDGkHTGPITCLQFNPKFMTFASA 300
Cdd:cd00200  233 LLASGSEDGTIRVWDLRTGECVQTLSG-HTNSVTSLAWSPDGKRLASG 279
WD40 COG2319
WD40 repeat [General function prediction only];
8-303 5.53e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 152.37  E-value: 5.53e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147904340   8 LRSFRVAKVFRENSDKINCFDFSPNGETVISSSDDDSIVLYDCQEGKPKRTLYSKKYGVDLIRYTHAANTVVYSSNkiDD 87
Cdd:COG2319   65 AAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSA--DG 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147904340  88 TIRYLSLHDNKYIRYFPGHSKRVVALSMSPVDDTFISGSLDKTIRLWDLRSPNCQGLMHLQGKPVCS--FDPEGLIFAAG 165
Cdd:COG2319  143 TVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSvaFSPDGKLLASG 222

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147904340 166 VNSEMVKLYDLRSfdKGPFATFKmqyDRTCEWTGLKFSNDGKLILISTNGSFIRLIDAFKGVVMHTFGGYANskAVTlEA 245
Cdd:COG2319  223 SADGTVRLWDLAT--GKLLRTLT---GHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSG--GVN-SV 294

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 147904340 246 SFTPDSQFIMIGSEDGKIHVWNGESGIKVAVLDGkHTGPITCLQFNPKFMTFASACSN 303
Cdd:COG2319  295 AFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTG-HTGAVRSVAFSPDGKTLASGSDD 351
WD40 COG2319
WD40 repeat [General function prediction only];
8-267 1.05e-42

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 151.60  E-value: 1.05e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147904340   8 LRSFRVAKVFRENSDKINCFDFSPNGETVISSSDDDSIVLYDCQEGKPKRTLYSKKYGVDLIRYTHAANTVVYSSNkiDD 87
Cdd:COG2319  149 LATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSA--DG 226

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147904340  88 TIRYLSLHDNKYIRYFPGHSKRVVALSMSPVDDTFISGSLDKTIRLWDLRSPNCQGLMHLQGKPVCS--FDPEGLIFAAG 165
Cdd:COG2319  227 TVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSvaFSPDGKLLASG 306

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147904340 166 VNSEMVKLYDLRSFDkgPFATFKmqyDRTCEWTGLKFSNDGKLILISTNGSFIRLIDAFKGVVMHTFGGYanSKAVTlEA 245
Cdd:COG2319  307 SDDGTVRLWDLATGK--LLRTLT---GHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGH--TGAVT-SV 378

                        250       260
                 ....*....|....*....|..
gi 147904340 246 SFTPDSQFIMIGSEDGKIHVWN 267
Cdd:COG2319  379 AFSPDGRTLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
28-303 9.28e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 130.42  E-value: 9.28e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147904340  28 DFSPNGETVISSSDDDSIVLYDCQEGKPKRTLYSKKYGVDLIRYTHAANTVVYSSNkiDDTIRYLSLHDNKYIRYFPGHS 107
Cdd:COG2319   43 AASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASA--DGTVRLWDLATGLLLRTLTGHT 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147904340 108 KRVVALSMSPVDDTFISGSLDKTIRLWDLRSPNCQGLMHLQGKPVCS--FDPEGLIFAAGVNSEMVKLYDLRSFDkgPFA 185
Cdd:COG2319  121 GAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSvaFSPDGKLLASGSDDGTVRLWDLATGK--LLR 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147904340 186 TFKmqyDRTCEWTGLKFSNDGKLILISTNGSFIRLIDAFKGVVMHTFGGYANS-KAVtleaSFTPDSQFIMIGSEDGKIH 264
Cdd:COG2319  199 TLT---GHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSvRSV----AFSPDGRLLASGSADGTVR 271

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 147904340 265 VWNGESGIKVAVLDGkHTGPITCLQFNPKFMTFASACSN 303
Cdd:COG2319  272 LWDLATGELLRTLTG-HSGGVNSVAFSPDGKLLASGSDD 309
WD40 COG2319
WD40 repeat [General function prediction only];
8-223 3.35e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 115.39  E-value: 3.35e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147904340   8 LRSFRVAKVFRENSDKINCFDFSPNGETVISSSDDDSIVLYDCQEGKPKRTLYSKKYGVDLIRYTHAANTVVYSSNkiDD 87
Cdd:COG2319  191 LATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSA--DG 268

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147904340  88 TIRYLSLHDNKYIRYFPGHSKRVVALSMSPVDDTFISGSLDKTIRLWDLRSPNCQGLMHLQGKPVCS--FDPEGLIFAAG 165
Cdd:COG2319  269 TVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSvaFSPDGKTLASG 348

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 147904340 166 VNSEMVKLYDLRSfdKGPFATFKmqyDRTCEWTGLKFSNDGKLILISTNGSFIRLIDA 223
Cdd:COG2319  349 SDDGTVRLWDLAT--GELLRTLT---GHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-267 1.64e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 105.88  E-value: 1.64e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147904340   8 LRSFRVAKVFRENSDKINCFDFSPNGETVISSSDDDSIVLYDCQEGKPKRTLYSKKYGVDLIRYTHAANTVVYSSNkiDD 87
Cdd:cd00200   80 LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQ--DG 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147904340  88 TIRYLSLHDNKYIRYFPGHSKRVVALSMSPVDDTFISGSLDKTIRLWDLRSPNCQGLMHLQGKPVCS--FDPEGLIFAAG 165
Cdd:cd00200  158 TIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSvaFSPDGYLLASG 237

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147904340 166 vnsemvklydlrsfdkgpfatfkmqydrtcewtglkfSNDGKlilistngsfIRLIDAFKGVVMHTFGGYANSkaVTLeA 245
Cdd:cd00200  238 -------------------------------------SEDGT----------IRVWDLRTGECVQTLSGHTNS--VTS-L 267

                        250       260
                 ....*....|....*....|..
gi 147904340 246 SFTPDSQFIMIGSEDGKIHVWN 267
Cdd:cd00200  268 AWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 100-308 6.22e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 104.34  E-value: 6.22e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147904340 100 IRYFPGHSKRVVALSMSPVDDTFISGSLDKTIRLWDLRSPNCQGLM--HLQGKPVCSFDPEG-LIFAAGVNSeMVKLYDL 176
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLkgHTGPVRDVAASADGtYLASGSSDK-TIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147904340 177 RSFDKgpFATFKMQydrTCEWTGLKFSNDGKLILISTNGSFIRLIDAFKGVVMHTFGGyaNSKAVTlEASFTPDSQFIMI 256
Cdd:cd00200   81 ETGEC--VRTLTGH---TSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRG--HTDWVN-SVAFSPDGTFVAS 152

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 147904340 257 GSEDGKIHVWNGESGIKVAVLDGkHTGPITCLQFNPKFMTFASACSNMAFWL 308
Cdd:cd00200  153 SSQDGTIKLWDLRTGKCVATLTG-HTGEVNSVAFSPDGEKLLSSSSDGTIKL 203
WD40 COG2319
WD40 repeat [General function prediction only];
8-138 2.84e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 95.75  E-value: 2.84e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147904340   8 LRSFRVAKVFRENSDKINCFDFSPNGETVISSSDDDSIVLYDCQEGKPKRTLYSKKYGVDLIRYTHAANTVVYSSNkiDD 87
Cdd:COG2319  275 LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSD--DG 352

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 147904340  88 TIRYLSLHDNKYIRYFPGHSKRVVALSMSPVDDTFISGSLDKTIRLWDLRS 138
Cdd:COG2319  353 TVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 96-135 6.29e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 6.29e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 147904340    96 DNKYIRYFPGHSKRVVALSMSPVDDTFISGSLDKTIRLWD 135
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
97-135 6.59e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.03  E-value: 6.59e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 147904340   97 NKYIRYFPGHSKRVVALSMSPVDDTFISGSLDKTIRLWD 135
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 10-49 6.70e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 6.70e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 147904340    10 SFRVAKVFRENSDKINCFDFSPNGETVISSSDDDSIVLYD 49
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
15-49 1.70e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 1.70e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 147904340   15 KVFRENSDKINCFDFSPNGETVISSSDDDSIVLYD 49
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 192-232 3.82e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 36.10  E-value: 3.82e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 147904340  192 DRTCEWTGLKFSNDGKLILISTNGSFIRLIDAFKGVVMHTF 232
Cdd:pfam12894  36 KEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHF 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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