NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|21313623|ref|NP_079608|]
View 

GTP-binding protein 8 isoform 1 [Mus musculus]

Protein Classification

GTP-binding protein( domain architecture ID 10785093)

GTP-binding protein similar to YsxC/EngB, a GTPase associated with ribosome biogenesis; belongs to the large superfamily of translation factor-related (TRAFAC) GTPases

CATH:  3.40.50.300
Gene Ontology:  GO:0046872|GO:0005525
PubMed:  16333325|11916378|11489118
SCOP:  4004043

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
EngB COG0218
GTP-binding protein EngB required for normal cell division [Cell cycle control, cell division, ...
 92-280 6.79e-64

GTP-binding protein EngB required for normal cell division [Cell cycle control, cell division, chromosome partitioning];


:

Pssm-ID: 439988 [Multi-domain]  Cd Length: 194  Bit Score: 199.14  E-value: 6.79e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313623  92 NRIEYLSSAVRLDHAPSLQQPEVCFIGRSNVGKSSLIKALF---SLApdvevRISKKPGHTKKMNFFKVGKHFTLVDMPG 168
Cdd:COG0218   4 KKAEFVTSAVKLEQLPPDDLPEIAFAGRSNVGKSSLINALTnrkKLA-----RTSKTPGKTQLINFFLINDKFYLVDLPG 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313623 169 YGY-RAP----EDFVDMVETYLKERNNLKRTFLLVDSVVGITKLDNIAIEMCEEFALPYVMILTKIDKSSKGYLLKQVLQ 243
Cdd:COG0218  79 YGYaKVSkaekEKWQKLIEDYLEGRENLKGVVLLIDIRHPPKELDLEMLEWLDEAGIPFLIVLTKADKLKKSELAKQLKA 158

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 21313623 244 IQKFVNtqTQGCFPQLFPISAVTNSGVHLLKCFIADI 280
Cdd:COG0218 159 IKKALG--KDPAAPEVILFSSLKKEGIDELRAAIEEW 193
 
Name Accession Description Interval E-value
EngB COG0218
GTP-binding protein EngB required for normal cell division [Cell cycle control, cell division, ...
 92-280 6.79e-64

GTP-binding protein EngB required for normal cell division [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 439988 [Multi-domain]  Cd Length: 194  Bit Score: 199.14  E-value: 6.79e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313623  92 NRIEYLSSAVRLDHAPSLQQPEVCFIGRSNVGKSSLIKALF---SLApdvevRISKKPGHTKKMNFFKVGKHFTLVDMPG 168
Cdd:COG0218   4 KKAEFVTSAVKLEQLPPDDLPEIAFAGRSNVGKSSLINALTnrkKLA-----RTSKTPGKTQLINFFLINDKFYLVDLPG 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313623 169 YGY-RAP----EDFVDMVETYLKERNNLKRTFLLVDSVVGITKLDNIAIEMCEEFALPYVMILTKIDKSSKGYLLKQVLQ 243
Cdd:COG0218  79 YGYaKVSkaekEKWQKLIEDYLEGRENLKGVVLLIDIRHPPKELDLEMLEWLDEAGIPFLIVLTKADKLKKSELAKQLKA 158

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 21313623 244 IQKFVNtqTQGCFPQLFPISAVTNSGVHLLKCFIADI 280
Cdd:COG0218 159 IKKALG--KDPAAPEVILFSSLKKEGIDELRAAIEEW 193
YihA_EngB cd01876
YihA (EngB) GTPase family; The YihA (EngB) subfamily of GTPases is typified by the E. coli ...
 113-281 1.15e-63

YihA (EngB) GTPase family; The YihA (EngB) subfamily of GTPases is typified by the E. coli YihA, an essential protein involved in cell division control. YihA and its orthologs are small proteins that typically contain less than 200 amino acid residues and consists of the GTPase domain only (some of the eukaryotic homologs contain an N-terminal extension of about 120 residues that might be involved in organellar targeting). Homologs of yihA are found in most Gram-positive and Gram-negative pathogenic bacteria, with the exception of Mycobacterium tuberculosis. The broad-spectrum nature of YihA and its essentiality for cell viability in bacteria make it an attractive antibacterial target.


Pssm-ID: 206665 [Multi-domain]  Cd Length: 170  Bit Score: 197.73  E-value: 1.15e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313623 113 EVCFIGRSNVGKSSLIKALFSLApdVEVRISKKPGHTKKMNFFKVGKHFTLVDMPGYGY-RAP----EDFVDMVETYLKE 187
Cdd:cd01876   1 EVAFAGRSNVGKSSLINALTNRK--KLARTSKTPGRTQLINFFNVGDKFRLVDLPGYGYaKVSkevrEKWGKLIEEYLEN 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313623 188 RNNLKRTFLLVDSVVGITKLDNIAIEMCEEFALPYVMILTKIDKSSKGYLLKQVLQIQKFVNtqTQGCFPQLFPISAVTN 267
Cdd:cd01876  79 RENLKGVVLLIDARHGPTPIDLEMLEFLEELGIPFLIVLTKADKLKKSELAKVLKKIKEELN--LFNILPPVILFSSKKG 156

                       170
                ....*....|....
gi 21313623 268 SGVHLLKCFIADIT 281
Cdd:cd01876 157 TGIDELRALIAEWL 170
GTPase_YsxC TIGR03598
ribosome biogenesis GTP-binding protein YsxC/EngB; Members of this protein family are a GTPase ...
 95-271 1.76e-60

ribosome biogenesis GTP-binding protein YsxC/EngB; Members of this protein family are a GTPase associated with ribosome biogenesis, typified by YsxC from Bacillus subutilis. The family is widely but not universally distributed among bacteria. Members commonly are called EngB based on homology to EngA, one of several other GTPases of ribosome biogenesis. Cutoffs as set find essentially all bacterial members, but also identify large numbers of eukaryotic (probably organellar) sequences. This protein is found in about 80 percent of bacterial genomes. [Protein synthesis, Other]


Pssm-ID: 274670 [Multi-domain]  Cd Length: 179  Bit Score: 189.61  E-value: 1.76e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313623    95 EYLSSAVRLDHAPSLQQPEVCFIGRSNVGKSSLIKALF---SLApdvevRISKKPGHTKKMNFFKVGKHFTLVDMPGYGY 171
Cdd:TIGR03598   2 EFVKSAVKLKQLPPDDGPEIAFAGRSNVGKSSLINALTnrkKLA-----RTSKTPGRTQLINFFEVNDGFRLVDLPGYGY 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313623   172 -RAPED----FVDMVETYLKERNNLKRTFLLVDSVVGITKLDNIAIEMCEEFALPYVMILTKIDKSSKGYLLKQVLQIQK 246
Cdd:TIGR03598  77 aKVSKEekekWQKLIEEYLEKRENLKGVVLLMDIRHPLKELDLEMIEWLRERGIPVLIVLTKADKLKKSELNKQLKKIKK 156

                         170       180
                  ....*....|....*....|....*
gi 21313623   247 FVNTQTQGCFPQLFpiSAVTNSGVH 271
Cdd:TIGR03598 157 ALKKDADDPSVQLF--SSLKKTGID 179
MMR_HSR1 pfam01926
50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete ...
 113-228 2.50e-22

50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete activity of the protein of interacting with the 50S ribosome and binding of both adenine and guanine nucleotides, with a preference for guanine nucleotide.


Pssm-ID: 460387 [Multi-domain]  Cd Length: 113  Bit Score: 89.22  E-value: 2.50e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313623   113 EVCFIGRSNVGKSSLIKALFslapDVEVRISKKPGHTKKMNFFKV---GKHFTLVDMPGYgYRAPEDFVDMVETYLKERN 189
Cdd:pfam01926   1 RVALVGRPNVGKSTLINALT----GAKAIVSDYPGTTRDPNEGRLelkGKQIILVDTPGL-IEGASEGEGLGRAFLAIIE 75

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 21313623   190 NlKRTFLLVDSVVGITKLDNIAIEMCEEFALPYVMILTK 228
Cdd:pfam01926  76 A-DLILFVVDSEEGITPLDEELLELLRENKKPIILVLNK 113
PRK04213 PRK04213
GTP-binding protein EngB;
112-231 4.54e-19

GTP-binding protein EngB;


Pssm-ID: 179790 [Multi-domain]  Cd Length: 201  Bit Score: 83.04  E-value: 4.54e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313623  112 PEVCFIGRSNVGKSSLIKALFSlapdVEVRISKKPGHTKKMNFFKVGKhFTLVDMPGYGYRA--PEDFVDMVET----YL 185
Cdd:PRK04213  10 PEIVFVGRSNVGKSTLVRELTG----KKVRVGKRPGVTRKPNHYDWGD-FILTDLPGFGFMSgvPKEVQEKIKDeivrYI 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 21313623  186 kERN--NLKRTFLLVD--SVVGI----TKLDNIAI--EM---CEEFALPYVMILTKIDK 231
Cdd:PRK04213  85 -EDNadRILAAVLVVDgkSFIEIierwEGRGEIPIdvEMfdfLRELGIPPIVAVNKMDK 142
 
Name Accession Description Interval E-value
EngB COG0218
GTP-binding protein EngB required for normal cell division [Cell cycle control, cell division, ...
 92-280 6.79e-64

GTP-binding protein EngB required for normal cell division [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 439988 [Multi-domain]  Cd Length: 194  Bit Score: 199.14  E-value: 6.79e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313623  92 NRIEYLSSAVRLDHAPSLQQPEVCFIGRSNVGKSSLIKALF---SLApdvevRISKKPGHTKKMNFFKVGKHFTLVDMPG 168
Cdd:COG0218   4 KKAEFVTSAVKLEQLPPDDLPEIAFAGRSNVGKSSLINALTnrkKLA-----RTSKTPGKTQLINFFLINDKFYLVDLPG 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313623 169 YGY-RAP----EDFVDMVETYLKERNNLKRTFLLVDSVVGITKLDNIAIEMCEEFALPYVMILTKIDKSSKGYLLKQVLQ 243
Cdd:COG0218  79 YGYaKVSkaekEKWQKLIEDYLEGRENLKGVVLLIDIRHPPKELDLEMLEWLDEAGIPFLIVLTKADKLKKSELAKQLKA 158

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 21313623 244 IQKFVNtqTQGCFPQLFPISAVTNSGVHLLKCFIADI 280
Cdd:COG0218 159 IKKALG--KDPAAPEVILFSSLKKEGIDELRAAIEEW 193
YihA_EngB cd01876
YihA (EngB) GTPase family; The YihA (EngB) subfamily of GTPases is typified by the E. coli ...
 113-281 1.15e-63

YihA (EngB) GTPase family; The YihA (EngB) subfamily of GTPases is typified by the E. coli YihA, an essential protein involved in cell division control. YihA and its orthologs are small proteins that typically contain less than 200 amino acid residues and consists of the GTPase domain only (some of the eukaryotic homologs contain an N-terminal extension of about 120 residues that might be involved in organellar targeting). Homologs of yihA are found in most Gram-positive and Gram-negative pathogenic bacteria, with the exception of Mycobacterium tuberculosis. The broad-spectrum nature of YihA and its essentiality for cell viability in bacteria make it an attractive antibacterial target.


Pssm-ID: 206665 [Multi-domain]  Cd Length: 170  Bit Score: 197.73  E-value: 1.15e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313623 113 EVCFIGRSNVGKSSLIKALFSLApdVEVRISKKPGHTKKMNFFKVGKHFTLVDMPGYGY-RAP----EDFVDMVETYLKE 187
Cdd:cd01876   1 EVAFAGRSNVGKSSLINALTNRK--KLARTSKTPGRTQLINFFNVGDKFRLVDLPGYGYaKVSkevrEKWGKLIEEYLEN 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313623 188 RNNLKRTFLLVDSVVGITKLDNIAIEMCEEFALPYVMILTKIDKSSKGYLLKQVLQIQKFVNtqTQGCFPQLFPISAVTN 267
Cdd:cd01876  79 RENLKGVVLLIDARHGPTPIDLEMLEFLEELGIPFLIVLTKADKLKKSELAKVLKKIKEELN--LFNILPPVILFSSKKG 156

                       170
                ....*....|....
gi 21313623 268 SGVHLLKCFIADIT 281
Cdd:cd01876 157 TGIDELRALIAEWL 170
GTPase_YsxC TIGR03598
ribosome biogenesis GTP-binding protein YsxC/EngB; Members of this protein family are a GTPase ...
 95-271 1.76e-60

ribosome biogenesis GTP-binding protein YsxC/EngB; Members of this protein family are a GTPase associated with ribosome biogenesis, typified by YsxC from Bacillus subutilis. The family is widely but not universally distributed among bacteria. Members commonly are called EngB based on homology to EngA, one of several other GTPases of ribosome biogenesis. Cutoffs as set find essentially all bacterial members, but also identify large numbers of eukaryotic (probably organellar) sequences. This protein is found in about 80 percent of bacterial genomes. [Protein synthesis, Other]


Pssm-ID: 274670 [Multi-domain]  Cd Length: 179  Bit Score: 189.61  E-value: 1.76e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313623    95 EYLSSAVRLDHAPSLQQPEVCFIGRSNVGKSSLIKALF---SLApdvevRISKKPGHTKKMNFFKVGKHFTLVDMPGYGY 171
Cdd:TIGR03598   2 EFVKSAVKLKQLPPDDGPEIAFAGRSNVGKSSLINALTnrkKLA-----RTSKTPGRTQLINFFEVNDGFRLVDLPGYGY 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313623   172 -RAPED----FVDMVETYLKERNNLKRTFLLVDSVVGITKLDNIAIEMCEEFALPYVMILTKIDKSSKGYLLKQVLQIQK 246
Cdd:TIGR03598  77 aKVSKEekekWQKLIEEYLEKRENLKGVVLLMDIRHPLKELDLEMIEWLRERGIPVLIVLTKADKLKKSELNKQLKKIKK 156

                         170       180
                  ....*....|....*....|....*
gi 21313623   247 FVNTQTQGCFPQLFpiSAVTNSGVH 271
Cdd:TIGR03598 157 ALKKDADDPSVQLF--SSLKKTGID 179
MMR_HSR1 pfam01926
50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete ...
 113-228 2.50e-22

50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete activity of the protein of interacting with the 50S ribosome and binding of both adenine and guanine nucleotides, with a preference for guanine nucleotide.


Pssm-ID: 460387 [Multi-domain]  Cd Length: 113  Bit Score: 89.22  E-value: 2.50e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313623   113 EVCFIGRSNVGKSSLIKALFslapDVEVRISKKPGHTKKMNFFKV---GKHFTLVDMPGYgYRAPEDFVDMVETYLKERN 189
Cdd:pfam01926   1 RVALVGRPNVGKSTLINALT----GAKAIVSDYPGTTRDPNEGRLelkGKQIILVDTPGL-IEGASEGEGLGRAFLAIIE 75

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 21313623   190 NlKRTFLLVDSVVGITKLDNIAIEMCEEFALPYVMILTK 228
Cdd:pfam01926  76 A-DLILFVVDSEEGITPLDEELLELLRENKKPIILVLNK 113
PRK04213 PRK04213
GTP-binding protein EngB;
112-231 4.54e-19

GTP-binding protein EngB;


Pssm-ID: 179790 [Multi-domain]  Cd Length: 201  Bit Score: 83.04  E-value: 4.54e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313623  112 PEVCFIGRSNVGKSSLIKALFSlapdVEVRISKKPGHTKKMNFFKVGKhFTLVDMPGYGYRA--PEDFVDMVET----YL 185
Cdd:PRK04213  10 PEIVFVGRSNVGKSTLVRELTG----KKVRVGKRPGVTRKPNHYDWGD-FILTDLPGFGFMSgvPKEVQEKIKDeivrYI 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 21313623  186 kERN--NLKRTFLLVD--SVVGI----TKLDNIAI--EM---CEEFALPYVMILTKIDK 231
Cdd:PRK04213  85 -EDNadRILAAVLVVDgkSFIEIierwEGRGEIPIdvEMfdfLRELGIPPIVAVNKMDK 142
Ras_like_GTPase cd00882
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like ...
 115-270 1.53e-12

Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This superfamily also includes proteins like the GTP translation factors, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Members of the Ras superfamily regulate a wide variety of cellular functions: the Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. The GTP translation factor family regulates initiation, elongation, termination, and release in translation, and the Era-like GTPase family regulates cell division, sporulation, and DNA replication. Members of the Ras superfamily are identified by the GTP binding site, which is made up of five characteristic sequence motifs, and the switch I and switch II regions.


Pssm-ID: 206648 [Multi-domain]  Cd Length: 161  Bit Score: 64.01  E-value: 1.53e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313623 115 CFIGRSNVGKSSLIKALFSLAPDVevrISKKPGHTKKMNFFKVGKH-----FTLVDMPGYGYRAPEDFVDMVETYLKERN 189
Cdd:cd00882   1 VVVGRGGVGKSSLLNALLGGEVGE---VSDVPGTTRDPDVYVKELDkgkvkLVLVDTPGLDEFGGLGREELARLLLRGAD 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313623 190 NLkrtFLLVDSVVGITKLD--NIAIEMCEEFALPYVMILTKIDKSSkGYLLKQVLQIQKFVNtqtqGCFPQLFPISAVTN 267
Cdd:cd00882  78 LI---LLVVDSTDRESEEDakLLILRRLRKEGIPIILVGNKIDLLE-EREVEELLRLEELAK----ILGVPVFEVSAKTG 149


                ...
gi 21313623 268 SGV 270
Cdd:cd00882 150 EGV 152
Era cd04163
E. coli Ras-like protein (Era) is a multifunctional GTPase; Era (E. coli Ras-like protein) is ...
 114-280 2.65e-12

E. coli Ras-like protein (Era) is a multifunctional GTPase; Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit, possibly by chaperoning the 16S rRNA. It also contacts several assembly elements of the 30S subunit. Era couples cell growth with cytokinesis and plays a role in cell division and energy metabolism. Homologs have also been found in eukaryotes. Era contains two domains: the N-terminal GTPase domain and a C-terminal domain KH domain that is critical for RNA binding. Both domains are important for Era function. Era is functionally able to compensate for deletion of RbfA, a cold-shock adaptation protein that is required for efficient processing of the 16S rRNA.


Pssm-ID: 206726 [Multi-domain]  Cd Length: 168  Bit Score: 63.63  E-value: 2.65e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313623 114 VCFIGRSNVGKSSLIKALfslapdVEVRI---SKKPGHTKK-----MNFfkvGKH-FTLVDMPGY---GYRAPEDFVDMV 181
Cdd:cd04163   6 VAIIGRPNVGKSTLLNAL------VGQKIsivSPKPQTTRNrirgiYTD---DDAqIIFVDTPGIhkpKKKLGERMVKAA 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313623 182 ETYLKERNNLkrtFLLVDSVVGITKLDNIAIEMCEEFALPYVMILTKIDKSSKGYLLKQVLQIQKFvntqtQGCFPQLFP 261
Cdd:cd04163  77 WSALKDVDLV---LFVVDASEWIGEGDEFILELLKKSKTPVILVLNKIDLVKDKEDLLPLLEKLKE-----LHPFAEIFP 148

                       170
                ....*....|....*....
gi 21313623 262 ISAVTNSGVHLLKCFIADI 280
Cdd:cd04163 149 ISALKGENVDELLEYIVEY 167
era PRK00089
GTPase Era; Reviewed
 114-274 9.09e-10

GTPase Era; Reviewed


Pssm-ID: 234624 [Multi-domain]  Cd Length: 292  Bit Score: 58.14  E-value: 9.09e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313623  114 VCFIGRSNVGKSSLIKALfslapdVEVRI---SKKPGHT-KKMNFFKVGKH--FTLVDMPGY--GYRAPEDF-VDMVETY 184
Cdd:PRK00089   8 VAIVGRPNVGKSTLLNAL------VGQKIsivSPKPQTTrHRIRGIVTEDDaqIIFVDTPGIhkPKRALNRAmNKAAWSS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313623  185 LKERNNLkrtFLLVDSVVGITKLDNIAIEMCEEFALPYVMILTKIDK-SSKGYLLKQVLQIQKFVNtqtqgcFPQLFPIS 263
Cdd:PRK00089  82 LKDVDLV---LFVVDADEKIGPGDEFILEKLKKVKTPVILVLNKIDLvKDKEELLPLLEELSELMD------FAEIVPIS 152

                        170
                 ....*....|.
gi 21313623  264 AVTNSGVHLLK 274
Cdd:PRK00089 153 ALKGDNVDELL 163
Era COG1159
GTPase Era, involved in 16S rRNA processing [Translation, ribosomal structure and biogenesis];
114-274 1.06e-09

GTPase Era, involved in 16S rRNA processing [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440773 [Multi-domain]  Cd Length: 290  Bit Score: 58.08  E-value: 1.06e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313623 114 VCFIGRSNVGKSSLIKALfslapdVEVRI---SKKPGHT-KKMNFFKVGKH--FTLVDMPGY---GYR-----------A 173
Cdd:COG1159   6 VAIVGRPNVGKSTLLNAL------VGQKVsivSPKPQTTrHRIRGIVTREDaqIVFVDTPGIhkpKRKlgrrmnkaawsA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313623 174 PEDfVDMVetylkernnlkrtFLLVDSVVGITKLDNIAIEMCEEFALPYVMILTKIDKSSKGYLLKQVLQIQKFVNtqtq 253
Cdd:COG1159  80 LED-VDVI-------------LFVVDATEKIGEGDEFILELLKKLKTPVILVINKIDLVKKEELLPLLAEYSELLD---- 141

                       170       180
                ....*....|....*....|.
gi 21313623 254 gcFPQLFPISAVTNSGVHLLK 274
Cdd:COG1159 142 --FAEIVPISALKGDNVDELL 160
HSR1_MMR1 cd01857
A circularly permuted subfamily of the Ras GTPases; Human HSR1 is localized to the human MHC ...
 114-168 2.04e-09

A circularly permuted subfamily of the Ras GTPases; Human HSR1 is localized to the human MHC class I region and is highly homologous to a putative GTP-binding protein, MMR1 from mouse. These proteins represent a new subfamily of GTP-binding proteins that has only eukaryote members. This subfamily shows a circular permutation of the GTPase signature motifs so that the C-terminal strands 5, 6, and 7 (strand 6 contains the G4 box with sequence NKXD) are relocated to the N-terminus.


Pssm-ID: 206750 [Multi-domain]  Cd Length: 140  Bit Score: 54.93  E-value: 2.04e-09
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 21313623 114 VCFIGRSNVGKSSLIKALFSlapDVEVRISKKPGHTKKMNFFKVGKHFTLVDMPG 168
Cdd:cd01857  85 IGLVGYPNVGKSSLINALVG---SKKVSVSSTPGKTKHFQTIFLEPGITLCDCPG 136
Era_like cd00880
E. coli Ras-like protein (Era)-like GTPase; The Era (E. coli Ras-like protein)-like family ...
 116-274 1.26e-08

E. coli Ras-like protein (Era)-like GTPase; The Era (E. coli Ras-like protein)-like family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngB), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs), to the exclusion of other GTPases. TrmE is ubiquitous in bacteria and is a widespread mitochondrial protein in eukaryotes, but is absent from archaea. The yeast member of TrmE family, MSS1, is involved in mitochondrial translation; bacterial members are often present in translation-related operons. FeoB represents an unusual adaptation of GTPases for high-affinity iron (II) transport. YihA (EngB) family of GTPases is typified by the E. coli YihA, which is an essential protein involved in cell division control. Era is characterized by a distinct derivative of the KH domain (the pseudo-KH domain) which is located C-terminal to the GTPase domain. EngA and its orthologs are composed of two GTPase domains and, since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an ancient gene duplication, rather than a fusion of evolutionarily distinct GTPases, gave rise to this family.


Pssm-ID: 206646 [Multi-domain]  Cd Length: 161  Bit Score: 53.02  E-value: 1.26e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313623 116 FIGRSNVGKSSLIKALFSLapdvEVRI-SKKPGHTKKMNFFKVGKH----FTLVDMPGygyrapedfVDMVETYLKERNn 190
Cdd:cd00880   2 IFGRPNVGKSSLLNALLGQ----NVGIvSPIPGTTRDPVRKEWELLplgpVVLIDTPG---------LDEEGGLGRERV- 67

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313623 191 lKRTF----------LLVDSVVGITKLDNIAIEMcEEFALPYVMILTKIDKSSKGyllKQVLQIQKFVNTQTQGCfpQLF 260
Cdd:cd00880  68 -EEARqvadradlvlLVVDSDLTPVEEEAKLGLL-RERGKPVLLVLNKIDLVPES---EEEELLRERKLELLPDL--PVI 140

                       170
                ....*....|....
gi 21313623 261 PISAVTNSGVHLLK 274
Cdd:cd00880 141 AVSALPGEGIDELR 154
EngA2 cd01895
EngA2 GTPase contains the second domain of EngA; This EngA2 subfamily CD represents the second ...
 114-271 5.52e-08

EngA2 GTPase contains the second domain of EngA; This EngA2 subfamily CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an ancient gene duplication, rather than a fusion of evolutionarily distinct GTPases, gave rise to this family. Although the exact function of these proteins has not been elucidated, studies have revealed that the E. coli EngA homolog, Der, and Neisseria gonorrhoeae EngA are essential for cell viability. A recent report suggests that E. coli Der functions in ribosome assembly and stability.


Pssm-ID: 206682 [Multi-domain]  Cd Length: 174  Bit Score: 51.66  E-value: 5.52e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313623 114 VCFIGRSNVGKSSLIKALfsLAPDVeVRISKKPGHTK---KMNFFKVGKHFTLVDMPGYGYRAPEDfvDMVETY--LKER 188
Cdd:cd01895   5 IAIIGRPNVGKSSLLNAL--LGEER-VIVSDIAGTTRdsiDVPFEYDGQKYTLIDTAGIRKKGKVT--EGIEKYsvLRTL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313623 189 NNLKR---TFLLVDSVVGITKLD-NIAiEMCEEFALPYVMILTK---IDKSSK-GYLLKQVLQIQ-KFVNtqtqgcFPQL 259
Cdd:cd01895  80 KAIERadvVLLVLDASEGITEQDlRIA-GLILEEGKALIIVVNKwdlVEKDEKtMKEFEKELRRKlPFLD------YAPI 152

                       170
                ....*....|..
gi 21313623 260 FPISAVTNSGVH 271
Cdd:cd01895 153 VFISALTGQGVD 164
YeeP COG3596
Predicted GTPase [General function prediction only];
108-231 6.25e-08

Predicted GTPase [General function prediction only];


Pssm-ID: 442815 [Multi-domain]  Cd Length: 318  Bit Score: 52.85  E-value: 6.25e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313623 108 SLQQPEVCFIGRSNVGKSSLIKALF--SLAPDVEVRiskkpGHTKKMNFFKV----GKHFTLVDMPGYGYRAPEDfvdmv 181
Cdd:COG3596  36 ELPPPVIALVGKTGAGKSSLINALFgaEVAEVGVGR-----PCTREIQRYRLesdgLPGLVLLDTPGLGEVNERD----- 105

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 21313623 182 etylKERNNLKRTFLLVDSVVGITKLDNIAIEMCEEFA---------LPYVMILTKIDK 231
Cdd:COG3596 106 ----REYRELRELLPEADLILWVVKADDRALATDEEFLqalraqypdPPVLVVLTQVDR 160
PRK00093 PRK00093
GTP-binding protein Der; Reviewed
 114-271 4.25e-07

GTP-binding protein Der; Reviewed


Pssm-ID: 234628 [Multi-domain]  Cd Length: 435  Bit Score: 50.82  E-value: 4.25e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313623  114 VCFIGRSNVGKSSLIKALF----SLAPDVevriskkPGHTK---KMNFFKVGKHFTLVDMPGYGYRApeDFVDMVETY-- 184
Cdd:PRK00093 176 IAIIGRPNVGKSSLINALLgeerVIVSDI-------AGTTRdsiDTPFERDGQKYTLIDTAGIRRKG--KVTEGVEKYsv 246

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313623  185 ---LK--ERNNLkrTFLLVDSVVGITKLD-NIAiEMCEEFALPYVMILTK---IDKSSKGYLLKQVLQIQKFVNtqtqgc 255
Cdd:PRK00093 247 irtLKaiERADV--VLLVIDATEGITEQDlRIA-GLALEAGRALVIVVNKwdlVDEKTMEEFKKELRRRLPFLD------ 317

                        170
                 ....*....|....*.
gi 21313623  256 FPQLFPISAVTNSGVH 271
Cdd:PRK00093 318 YAPIVFISALTGQGVD 333
YqeH cd01855
Circularly permuted YqeH GTPase; YqeH is an essential GTP-binding protein. Depletion of YqeH ...
 116-169 1.22e-06

Circularly permuted YqeH GTPase; YqeH is an essential GTP-binding protein. Depletion of YqeH induces an excess initiation of DNA replication, suggesting that it negatively controls initiation of chromosome replication. The YqeH subfamily is common in eukaryotes and sporadically present in bacteria with probable acquisition by plants from chloroplasts. Proteins of the YqeH family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases.


Pssm-ID: 206748 [Multi-domain]  Cd Length: 191  Bit Score: 48.03  E-value: 1.22e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21313623 116 FIGRSNVGKSSLIKALF------SLAPDVEVRI--SKKPGHTKKMNFFKVGKHFTLVDMPGY 169
Cdd:cd01855 130 VVGATNVGKSTLINALLksnggkVQAQALVQRLtvSPIPGTTLGLIKIPLGEGKKLYDTPGI 191
GTP_translation_factor cd00881
GTP translation factor family primarily contains translation initiation, elongation and ...
 114-273 1.53e-06

GTP translation factor family primarily contains translation initiation, elongation and release factors; The GTP translation factor family consists primarily of translation initiation, elongation, and release factors, which play specific roles in protein translation. In addition, the family includes Snu114p, a component of the U5 small nuclear riboprotein particle which is a component of the spliceosome and is involved in excision of introns, TetM, a tetracycline resistance gene that protects the ribosome from tetracycline binding, and the unusual subfamily CysN/ATPS, which has an unrelated function (ATP sulfurylase) acquired through lateral transfer of the EF1-alpha gene and development of a new function.


Pssm-ID: 206647 [Multi-domain]  Cd Length: 183  Bit Score: 47.67  E-value: 1.53e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313623 114 VCFIGRSNVGKSSLIKALFSLAPDVEVR------------------ISKKPGHtkkMNFFKVGKHFTLVDMPGYgyrapE 175
Cdd:cd00881   2 VGVIGHVDHGKTTLTGSLLYQTGAIDRRgtrketfldtlkeerergITIKTGV---VEFEWPKRRINFIDTPGH-----E 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313623 176 DFVDMVETYLKERNNLkrtFLLVDSVVGITKLDNIAIEMCEEFALPYVMILTKIDKSSKGYLLKQVLQIQKFVN----TQ 251
Cdd:cd00881  74 DFSKETVRGLAQADGA---LLVVDANEGVEPQTREHLNIALAGGLPIIVAVNKIDRVGEEDFDEVLREIKELLKligfTF 150

                       170       180
                ....*....|....*....|..
gi 21313623 252 TQGCFPQLFPISAVTNSGVHLL 273
Cdd:cd00881 151 LKGKDVPIIPISALTGEGIEEL 172
YlqF cd01856
Circularly permuted YlqF GTPase; Proteins of the YlqF family contain all sequence motifs ...
 121-168 3.37e-06

Circularly permuted YlqF GTPase; Proteins of the YlqF family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases. The YlqF subfamily is represented in all eukaryotes as well as a phylogenetically diverse array of bacteria (including gram-positive bacteria, proteobacteria, Synechocystis, Borrelia, and Thermotoga).


Pssm-ID: 206749 [Multi-domain]  Cd Length: 171  Bit Score: 46.37  E-value: 3.37e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 21313623 121 NVGKSSLIKALfslapdVEVRISK---KPGHTKKMNFFKVGKHFTLVDMPG 168
Cdd:cd01856 125 NVGKSTLINRL------RGKKVAKvgnKPGVTRGQQWIRIGPNIELLDTPG 169
MJ1464 cd01859
An uncharacterized, circularly permuted subfamily of the Ras GTPases; This family represents ...
 114-168 5.98e-06

An uncharacterized, circularly permuted subfamily of the Ras GTPases; This family represents archaeal GTPase typified by the protein MJ1464 from Methanococcus jannaschii. The members of this family show a circular permutation of the GTPase signature motifs so that C-terminal strands 5, 6, and 7 (strands 6 contain the NKxD motif) are relocated to the N terminus.


Pssm-ID: 206752 [Multi-domain]  Cd Length: 157  Bit Score: 45.39  E-value: 5.98e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 21313623 114 VCFIGRSNVGKSSLIKALFSLAPDVEVRISKKPGHTKKMNFFKVGKHFTLVDMPG 168
Cdd:cd01859 102 VGVVGYPKVGKSSIINALKGRHSASTSPIPGSPGYTKGIQLVRIDSKIYLIDTPG 156
GTP_EFTU pfam00009
Elongation factor Tu GTP binding domain; This domain contains a P-loop motif, also found in ...
 114-273 7.05e-06

Elongation factor Tu GTP binding domain; This domain contains a P-loop motif, also found in several other families such as pfam00071, pfam00025 and pfam00063. Elongation factor Tu consists of three structural domains, this plus two C-terminal beta barrel domains.


Pssm-ID: 425418 [Multi-domain]  Cd Length: 187  Bit Score: 45.59  E-value: 7.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313623   114 VCFIGRSNVGKSSLIKALFSLAPDVEVRISKKPGHTKKMNFFKV------------------GKHFTLVDMPGYgyrapE 175
Cdd:pfam00009   6 IGIIGHVDHGKTTLTDRLLYYTGAISKRGEVKGEGEAGLDNLPEerergitiksaavsfetkDYLINLIDTPGH-----V 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313623   176 DFVDMVETYLkernnlkRT----FLLVDSVVGIT----KLDNIAIEMceefALPYVMILTKIDKSSKGYLLKQVLQIQ-K 246
Cdd:pfam00009  81 DFVKEVIRGL-------AQadgaILVVDAVEGVMpqtrEHLRLARQL----GVPIIVFINKMDRVDGAELEEVVEEVSrE 149

                         170       180
                  ....*....|....*....|....*...
gi 21313623   247 FVNTQ-TQGCFPQLFPISAVTNSGVHLL 273
Cdd:pfam00009 150 LLEKYgEDGEFVPVVPGSALKGEGVQTL 177
RbgA COG1161
Ribosome biogenesis GTPase RbgA [Translation, ribosomal structure and biogenesis];
121-168 7.59e-06

Ribosome biogenesis GTPase RbgA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440775 [Multi-domain]  Cd Length: 279  Bit Score: 46.25  E-value: 7.59e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 21313623 121 NVGKSSLIKALfslAPDVEVRISKKPGHTKKMNFFKVGKHFTLVDMPG 168
Cdd:COG1161 123 NVGKSTLINRL---AGKKVAKTGNKPGVTKGQQWIKLDDGLELLDTPG 167
Obg_like cd01881
Obg-like family of GTPases consist of five subfamilies: Obg, DRG, YyaF/YchF, Ygr210, and NOG1; ...
 116-274 1.10e-05

Obg-like family of GTPases consist of five subfamilies: Obg, DRG, YyaF/YchF, Ygr210, and NOG1; The Obg-like subfamily consists of five well-delimited, ancient subfamilies, namely Obg, DRG, YyaF/YchF, Ygr210, and NOG1. Four of these groups (Obg, DRG, YyaF/YchF, and Ygr210) are characterized by a distinct glycine-rich motif immediately following the Walker B motif (G3 box). Obg/CgtA is an essential gene that is involved in the initiation of sporulation and DNA replication in the bacteria Caulobacter and Bacillus, but its exact molecular role is unknown. Furthermore, several OBG family members possess a C-terminal RNA-binding domain, the TGS domain, which is also present in threonyl-tRNA synthetase and in bacterial guanosine polyphosphatase SpoT. Nog1 is a nucleolar protein that might function in ribosome assembly. The DRG and Nog1 subfamilies are ubiquitous in archaea and eukaryotes, the Ygr210 subfamily is present in archaea and fungi, and the Obg and YyaF/YchF subfamilies are ubiquitous in bacteria and eukaryotes. The Obg/Nog1 and DRG subfamilies appear to form one major branch of the Obg family and the Ygr210 and YchF subfamilies form another branch. No GEFs, GAPs, or GDIs for Obg have been identified.


Pssm-ID: 206668 [Multi-domain]  Cd Length: 167  Bit Score: 44.69  E-value: 1.10e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313623 116 FIGRSNVGKSSLIKALFSlapdVEVRISKKPGHTKKMNF----FKVGKHFTLVDMPGYGYRAPEDfVDMVETYLKernNL 191
Cdd:cd01881   2 LVGLPNVGKSTLLSALTS----AKVEIASYPFTTLEPNVgvfeFGDGVDIQIIDLPGLLDGASEG-RGLGEQILA---HL 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313623 192 KRTFLLVdSVVGITK---------LDNIAIEMCEEFA----LPYVMILTKIDKSSKGYLLKQVLQIQKfvntqtQGcfPQ 258
Cdd:cd01881  74 YRSDLIL-HVIDASEdcvgdpledQKTLNEEVSGSFLflknKPEMIVANKIDMASENNLKRLKLDKLK------RG--IP 144

                       170
                ....*....|....*.
gi 21313623 259 LFPISAVTNSGVHLLK 274
Cdd:cd01881 145 VVPTSALTRLGLDRVI 160
Der COG1160
Double Era-like domain GTPase Der [Translation, ribosomal structure and biogenesis];
114-271 3.67e-05

Double Era-like domain GTPase Der [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440774 [Multi-domain]  Cd Length: 438  Bit Score: 44.63  E-value: 3.67e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313623 114 VCFIGRSNVGKSSLIKALF----SLAPDVevriskkPGHTK-----KMNFFkvGKHFTLVDMPGYGYRAPEDfvDMVETY 184
Cdd:COG1160 178 IAIVGRPNVGKSSLINALLgeerVIVSDI-------AGTTRdsidtPFERD--GKKYTLIDTAGIRRKGKVD--EGIEKY 246

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313623 185 --LKERNNLKRT---FLLVDSVVGITKLD-NIAiEMCEEFALPYVMILTKID-----KSSKGYLLKQVLQIQKFVNtqtq 253
Cdd:COG1160 247 svLRTLRAIERAdvvLLVIDATEGITEQDlKIA-GLALEAGKALVIVVNKWDlvekdRKTREELEKEIRRRLPFLD---- 321

                       170
                ....*....|....*...
gi 21313623 254 gcFPQLFPISAVTNSGVH 271
Cdd:COG1160 322 --YAPIVFISALTGQGVD 337
YfjP cd11383
YfjP GTPase; The Era (E. coli Ras-like protein)-like YfjP subfamily includes several ...
 116-223 1.29e-04

YfjP GTPase; The Era (E. coli Ras-like protein)-like YfjP subfamily includes several uncharacterized bacterial GTPases that are similar to Era. They generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs), to the exclusion of other GTPases. Era is characterized by a distinct derivative of the KH domain (the pseudo-KH domain) which is located C-terminal to the GTPase domain.


Pssm-ID: 206743 [Multi-domain]  Cd Length: 140  Bit Score: 41.17  E-value: 1.29e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313623 116 FIGRSNVGKSSLIKALF--SLAPDVEVRiskkPGHTKKMNF-FKVGKHF-TLVDMPGYGYRAPED--FVDMVETYLKErn 189
Cdd:cd11383   2 LMGKTGAGKSSLCNALFgtEVAAVGDRR----PTTRAAQAYvWQTGGDGlVLLDLPGVGERGRRDreYEELYRRLLPE-- 75

                        90       100       110
                ....*....|....*....|....*....|....
gi 21313623 190 nlkrtfllVDSVVGITKLDNIAIEMCEEFALPYV 223
Cdd:cd11383  76 --------ADLVLWLLDADDRALAADHDFYLLPL 101
Nucleostemin_like cd04178
A circularly permuted subfamily of the Ras GTPases; Nucleostemin (NS) is a nucleolar protein ...
 117-169 1.48e-04

A circularly permuted subfamily of the Ras GTPases; Nucleostemin (NS) is a nucleolar protein that functions as a regulator of cell growth and proliferation in stem cells and in several types of cancer cells, but is not expressed in the differentiated cells of most mammalian adult tissues. NS shuttles between the nucleolus and nucleoplasm bidirectionally at a rate that is fast and independent of cell type. Lowering GTP levels decreases the nucleolar retention of NS, and expression of NS is abruptly down-regulated during differentiation prior to terminal cell division. Found only in eukaryotes, NS consists of an N-terminal basic domain, a coiled-coil domain, a GTP-binding domain, an intermediate domain, and a C-terminal acidic domain. Experimental evidence indicates that NS uses its GTP-binding property as a molecular switch to control the transition between the nucleolus and nucleoplasm, and this process involves interaction between the basic, GTP-binding, and intermediate domains of the protein.


Pssm-ID: 206753 [Multi-domain]  Cd Length: 171  Bit Score: 41.41  E-value: 1.48e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 21313623 117 IGRSNVGKSSLIKALF-SLApdveVRISKKPGHTKKMNFFKVGKHFTLVDMPGY 169
Cdd:cd04178 122 VGYPNVGKSSVINSLKrSRA----CNVGATPGVTKSMQEVHLDKHVKLLDSPGV 171
Der COG1160
Double Era-like domain GTPase Der [Translation, ribosomal structure and biogenesis];
112-273 5.48e-04

Double Era-like domain GTPase Der [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440774 [Multi-domain]  Cd Length: 438  Bit Score: 41.16  E-value: 5.48e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313623 112 PEVCFIGRSNVGKSSLIKALfslapdVEVRIS---KKPGHTKKMNFFKV---GKHFTLVDMPGYGYRAPEDFVDM----V 181
Cdd:COG1160   3 PVVAIVGRPNVGKSTLFNRL------TGRRDAivdDTPGVTRDRIYGEAewgGREFTLIDTGGIEPDDDDGLEAEireqA 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313623 182 ETYLKERNNLkrtFLLVDSVVGITKLDniaiemcEEFA--L-----PYVMILTKIDKsskgylLKQVLQIQKFVNTqtqG 254
Cdd:COG1160  77 ELAIEEADVI---LFVVDGRAGLTPLD-------EEIAklLrrsgkPVILVVNKVDG------PKREADAAEFYSL---G 137

                       170
                ....*....|....*....
gi 21313623 255 cFPQLFPISAVTNSGVHLL 273
Cdd:COG1160 138 -LGEPIPISAEHGRGVGDL 155
Gem1 COG1100
GTPase SAR1 family domain [General function prediction only];
114-280 9.35e-04

GTPase SAR1 family domain [General function prediction only];


Pssm-ID: 440717 [Multi-domain]  Cd Length: 177  Bit Score: 39.19  E-value: 9.35e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313623 114 VCFIGRSNVGKSSLIKAL----FSLAPD---VEVRISKK----PGHTKKMNffkvgkhftLVDMPGYgyrapEDFVDMVE 182
Cdd:COG1100   6 IVVVGTGGVGKTSLVNRLvgdiFSLEKYlstNGVTIDKKelklDGLDVDLV---------IWDTPGQ-----DEFRETRQ 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313623 183 TYLKERNNLKRTFLLVDSVVGITKLDNI-AIEMCEEFAL--PYVMILTKIDKSSKGYLLKQVLQIQKFVNTQtqgcFPQL 259
Cdd:COG1100  72 FYARQLTGASLYLFVVDGTREETLQSLYeLLESLRRLGKksPIILVLNKIDLYDEEEIEDEERLKEALSEDN----IVEV 147

                       170       180
                ....*....|....*....|.
gi 21313623 260 FPISAVTNSGVHLLKCFIADI 280
Cdd:COG1100 148 VATSAKTGEGVEELFAALAEI 168
YlqF_related_GTPase cd01849
Circularly permuted YlqF-related GTPases; These proteins are found in bacteria, eukaryotes, ...
 116-168 1.23e-03

Circularly permuted YlqF-related GTPases; These proteins are found in bacteria, eukaryotes, and archaea. They all exhibit a circular permutation of the GTPase signature motifs so that the order of the conserved G box motifs is G4-G5-G1-G2-G3, with G4 and G5 being permuted from the C-terminal region of proteins in the Ras superfamily to the N-terminus of YlqF-related GTPases.


Pssm-ID: 206746 [Multi-domain]  Cd Length: 146  Bit Score: 38.52  E-value: 1.23e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 21313623 116 FIGRSNVGKSSLIKAlfsLAPDVEVRISKKPGHTKKMNFFKVGKHFTLVDMPG 168
Cdd:cd01849  96 VVGLPNVGKSSFINA---LLNKFKLKVGSIPGTTKLQQDVKLDKEIYLYDTPG 145
EngA1 cd01894
EngA1 GTPase contains the first domain of EngA; This EngA1 subfamily CD represents the first ...
 117-273 1.64e-03

EngA1 GTPase contains the first domain of EngA; This EngA1 subfamily CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an ancient gene duplication, rather than a fusion of evolutionarily distinct GTPases, gave rise to this family. Although the exact function of these proteins has not been elucidated, studies have revealed that the E. coli EngA homolog, Der, and Neisseria gonorrhoeae EngA are essential for cell viability. A recent report suggests that E. coli Der functions in ribosome assembly and stability.


Pssm-ID: 206681 [Multi-domain]  Cd Length: 157  Bit Score: 38.19  E-value: 1.64e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313623 117 IGRSNVGKSSLikalFSlapdvevRISKK--------PGHT---KKMNFFKVGKHFTLVDMPGYGYRAPEDFVDM---VE 182
Cdd:cd01894   3 VGRPNVGKSTL----FN-------RLTGRrdaivsdtPGVTrdrKYGEAEWGGREFILIDTGGIEPDDEGISKEIreqAE 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313623 183 TYLKERNNLkrtFLLVDSVVGITKLDNIAIEMCEEFALPYVMILTKIDKsskgylLKQVLQIQKFVNTqtqGcFPQLFPI 262
Cdd:cd01894  72 IAIEEADVI---LFVVDGREGLTPADEEIAKYLRKSKKPVILVVNKIDN------IKEEEEAAEFYSL---G-FGEPIPI 138

                       170
                ....*....|.
gi 21313623 263 SAVTNSGVHLL 273
Cdd:cd01894 139 SAEHGRGIGDL 149
FeoB cd01879
Ferrous iron transport protein B (FeoB) family; Ferrous iron transport protein B (FeoB) ...
 115-283 3.74e-03

Ferrous iron transport protein B (FeoB) family; Ferrous iron transport protein B (FeoB) subfamily. E. coli has an iron(II) transport system, known as feo, which may make an important contribution to the iron supply of the cell under anaerobic conditions. FeoB has been identified as part of this transport system. FeoB is a large 700-800 amino acid integral membrane protein. The N terminus contains a P-loop motif suggesting that iron transport may be ATP dependent.


Pssm-ID: 206667 [Multi-domain]  Cd Length: 159  Bit Score: 37.05  E-value: 3.74e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313623 115 CFIGRSNVGKSSLIKALFSLApdveVRISKKPGHT--KKMNFFKV-GKHFTLVDMPG-Y--GYRAPEDFVdmVETYLKER 188
Cdd:cd01879   1 ALVGNPNVGKTTLFNALTGAR----QKVGNWPGVTveKKEGEFKLgGKEIEIVDLPGtYslTPYSEDEKV--ARDFLLGE 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313623 189 N-----------NLKRTFLLVDSVVgitkldniaiemceEFALPYVMILTKIDKS-SKGY-----LLKQVLqiqkfvntq 251
Cdd:cd01879  75 EpdlivnvvdatNLERNLYLTLQLL--------------ELGLPVVVALNMIDEAeKRGIkidldKLSELL--------- 131

                       170       180       190
                ....*....|....*....|....*....|..
gi 21313623 252 tqGCfpQLFPISAVTNSGVHLLKCFIADITGS 283
Cdd:cd01879 132 --GV--PVVPTSARKGEGIDELLDAIAKLAES 159
RsgA_GTPase pfam03193
RsgA GTPase; RsgA (also known as EngC and YjeQ) represents a protein family whose members are ...
 114-171 4.55e-03

RsgA GTPase; RsgA (also known as EngC and YjeQ) represents a protein family whose members are broadly conserved in bacteria and are indispensable for growth. The GTPase domain of RsgA is very similar to several P-loop GTPases, but differs in having a circular permutation of the GTPase structure described by a G4-G1-G3 pattern.


Pssm-ID: 427191 [Multi-domain]  Cd Length: 174  Bit Score: 37.14  E-value: 4.55e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21313623   114 VCFIGRSNVGKSSLIKAlfsLAPDVEVRISKKPGHTKKmnffkvGKHFT----LVDMPGYGY 171
Cdd:pfam03193 109 TVLAGQSGVGKSTLLNA---LLPELDLRTGEISEKLGR------GRHTTthveLFPLPGGGL 161
PRK12289 PRK12289
small ribosomal subunit biogenesis GTPase RsgA;
118-173 4.59e-03

small ribosomal subunit biogenesis GTPase RsgA;


Pssm-ID: 237040 [Multi-domain]  Cd Length: 352  Bit Score: 38.07  E-value: 4.59e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313623  118 GRSNVGKSSLIKALFslaPDVEVRISKKPGHTKKmnffkvGKHFT----LVDMPGYGYRA 173
Cdd:PRK12289 179 GPSGVGKSSLINRLI---PDVELRVGKVSGKLGR------GRHTTrhveLFELPNGGLLA 229
Septin pfam00735
Septin; Members of this family include CDC3, CDC10, CDC11 and CDC12/Septin. Members of this ...
 117-202 4.59e-03

Septin; Members of this family include CDC3, CDC10, CDC11 and CDC12/Septin. Members of this family bind GTP. As regards the septins, these are polypeptides of 30-65kDa with three characteriztic GTPase motifs (G-1, G-3 and G-4) that are similar to those of the Ras family. The G-4 motif is strictly conserved with a unique septin consensus of AKAD. Most septins are thought to have at least one coiled-coil region, which in some cases is necessary for intermolecular interactions that allow septins to polymerize to form rod-shaped complexes. In turn, these are arranged into tandem arrays to form filaments. They are multifunctional proteins, with roles in cytokinesis, sporulation, germ cell development, exocytosis and apoptosis.


Pssm-ID: 395596  Cd Length: 272  Bit Score: 37.66  E-value: 4.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313623   117 IGRSNVGKSSLIKALFsLAPDVEVRISKKPGHTKKMNF-FKVGKH----------FTLVDMPGYGyrapeDFVD------ 179
Cdd:pfam00735   9 VGESGLGKTTFINTLF-LTDLYRARGIPGPSEKIKKTVeIKAYTVeieedgvklnLTVIDTPGFG-----DAIDnsncwr 82

                          90       100       110
                  ....*....|....*....|....*....|.
gi 21313623   180 -MV-------ETYLKERNNLKRTFlLVDSVV 202
Cdd:pfam00735  83 pIVeyideqyEQYLRDESGLNRKS-IKDNRV 112
YjeQ_EngC cd01854
Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; ...
 114-171 5.44e-03

Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; YjeQ (YloQ in Bacillus subtilis) is a ribosomal small subunit-dependent GTPase; hence also known as RsgA. YjeQ is a late-stage ribosomal biogenesis factor involved in the 30S subunit maturation, and it represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases. All YjeQ family proteins display a unique domain architecture, which includes an N-terminal OB-fold RNA-binding domain, the central permuted GTPase domain, and a zinc knuckle-like C-terminal cysteine domain.


Pssm-ID: 206747 [Multi-domain]  Cd Length: 211  Bit Score: 37.38  E-value: 5.44e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21313623 114 VCFIGRSNVGKSSLIKAlfsLAPDVEVR---ISKKpghTKKmnffkvGKHFT----LVDMPGYGY 171
Cdd:cd01854  88 SVLVGQSGVGKSTLLNA---LLPELVLAtgeISEK---LGR------GRHTTthreLFPLPGGGL 140
CDC_Septin cd01850
CDC/Septin GTPase family; Septins are a conserved family of GTP-binding proteins associated ...
 117-202 5.53e-03

CDC/Septin GTPase family; Septins are a conserved family of GTP-binding proteins associated with diverse processes in dividing and non-dividing cells. They were first discovered in the budding yeast S. cerevisiae as a set of genes (CDC3, CDC10, CDC11 and CDC12) required for normal bud morphology. Septins are also present in metazoan cells, where they are required for cytokinesis in some systems, and implicated in a variety of other processes involving organization of the cell cortex and exocytosis. In humans, 12 septin genes generate dozens of polypeptides, many of which comprise heterooligomeric complexes. Since septin mutants are commonly defective in cytokinesis and formation of the neck formation of the neck filaments/septin rings, septins have been considered to be the primary constituents of the neck filaments. Septins belong to the GTPase superfamily for their conserved GTPase motifs and enzymatic activities.


Pssm-ID: 206649  Cd Length: 275  Bit Score: 37.53  E-value: 5.53e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313623 117 IGRSNVGKSSLIKALFS---------------LAPDVEVRISKkpgHTKKMNFFKVgkHFTLVDMPGYGyrapeDFVD-- 179
Cdd:cd01850  10 VGESGLGKSTFINTLFGtklypskyppapgehITKTVEIKISK---AELEENGVKL--KLTVIDTPGFG-----DNINns 79

                        90       100       110
                ....*....|....*....|....*....|....*
gi 21313623 180 -----MV-------ETYLKERNNLKRTFLLVDSVV 202
Cdd:cd01850  80 dcwkpIVdyiddqfESYLREESRINRNRRIPDTRV 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH